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https://ntp.niehs.nih.gov/go/3842

TR 395 Mouse Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                             PROBENECID


NTP Experiment-Test: 05030-02                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/04/94
Route: GAVAGE                                                                                                     Time: 15:09:51




       Facility:  TSI Mason Research

       Chemical CAS #:  000057669

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05030-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             PROBENECID                                        Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 15:09:51  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      .1G/KG       .4G/KG                                                 
                                                    FEMALE       LF           HF                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund                                           9            9            9                                                  
    Dead                                               8            7            9                                                  
    Accident                                                        1                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                32           31           32                                                  
    Moribund                                                        1                                                               
  Other                                                1            1                                                               
  Animals Examined Microscopically                    49           49           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (48)         (15)         (49)                                                
      Lymphoid Nodule, Hyperplasia                                  1 (7%)                                                          
   Intestine Small, Ileum                             (47)         (16)         (46)                                                
      Necrosis                                         1 (2%)                                                                       
      Lymphoid Nodule, Hyperplasia                                               1 (2%)                                             
   Intestine Small, Jejunum                           (46)         (14)         (44)                                                
      Necrosis                                         1 (2%)                                                                       
      Lymphoid Nodule, Hemorrhage                      1 (2%)                                                                       
      Lymphoid Nodule, Hyperplasia                                               1 (2%)                                             
   Liver                                              (48)         (49)         (49)                                                
      Angiectasis                                                                2 (4%)                                             
      Basophilic Focus                                 2 (4%)                    2 (4%)                                             
      Clear Cell Focus                                 1 (2%)                                                                       
      Congestion                                                    1 (2%)                                                          
      Cyst                                                                       2 (4%)                                             
      Eosinophilic Focus                                                         2 (4%)                                             
      Fatty Change                                                               1 (2%)                                             
      Fatty Change, Diffuse                            1 (2%)       1 (2%)                                                          
      Fatty Change, Focal                              2 (4%)       8 (16%)      2 (4%)                                             
      Hematopoietic Cell Proliferation                 1 (2%)       7 (14%)      7 (14%)                                            
      Mineralization                                   2 (4%)                                                                       
      Necrosis                                        10 (21%)      4 (8%)       4 (8%)                                             
      Necrosis, Coagulative                                         1 (2%)       1 (2%)                                             
      Bile Duct, Hyperplasia, Cystic                                1 (2%)                                                          
   Mesentery                                          (3)          (5)          (9)                                                 
      Hemorrhage                                                    1 (20%)                                                         
      Inflammation, Acute                              1 (33%)      3 (60%)      8 (89%)                                            
      Inflammation, Chronic Active                     1 (33%)                                                                      
      Fat, Inflammation, Chronic Active                1 (33%)      1 (20%)                                                         
      Fat, Necrosis                                    1 (33%)      1 (20%)      1 (11%)                                            
   Pancreas                                           (48)         (19)         (47)                                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05030-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             PROBENECID                                        Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 15:09:51  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      .1G/KG       .4G/KG                                                 
                                                    FEMALE       LF           HF                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Acinus, Atrophy                                                            1 (2%)                                             
      Acinus, Hyperplasia                              2 (4%)                                                                       
   Salivary Glands                                    (45)         (15)         (49)                                                
      Mineralization                                   1 (2%)                                                                       
   Stomach, Forestomach                               (47)         (49)         (49)                                                
      Acanthosis                                      11 (23%)     11 (22%)      7 (14%)                                            
      Hyperkeratosis                                  14 (30%)     12 (24%)      9 (18%)                                            
      Inflammation, Acute                              2 (4%)                    1 (2%)                                             
      Inflammation, Chronic Active                                  1 (2%)       2 (4%)                                             
      Mineralization                                   1 (2%)                                                                       
      Necrosis                                         2 (4%)       6 (12%)      1 (2%)                                             
   Stomach, Glandular                                 (46)         (48)         (48)                                                
      Dilatation                                       1 (2%)                                                                       
      Hyperplasia                                      5 (11%)     14 (29%)      1 (2%)                                             
      Inflammation, Acute                                           1 (2%)                                                          
      Inflammation, Chronic Active                     1 (2%)       2 (4%)       1 (2%)                                             
      Necrosis                                                                   1 (2%)                                             
      Pigmentation                                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (48)         (15)         (49)                                                
      Cardiomyopathy                                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (48)         (14)         (49)                                                
      Capsule, Hyperplasia                            38 (79%)      7 (50%)     43 (88%)                                            
   Adrenal Gland, Cortex                              (48)         (14)         (49)                                                
      Accessory Adrenal Cortical Nodule                1 (2%)                                                                       
      Cyst                                             1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 2 (4%)       1 (7%)       5 (10%)                                            
      Hyperplasia                                     37 (77%)      7 (50%)     39 (80%)                                            
      Hypertrophy                                      1 (2%)                    1 (2%)                                             
   Adrenal Gland, Medulla                             (44)         (13)         (44)                                                
      Degeneration                                     1 (2%)                                                                       
   Pituitary Gland                                    (41)         (13)         (38)                                                
      Angiectasis                                      1 (2%)                                                                       
      Pars Distalis, Angiectasis                       3 (7%)                    5 (13%)                                            
      Pars Distalis, Cyst                                                        1 (3%)                                             
      Pars Distalis, Hyperplasia                      13 (32%)      2 (15%)      8 (21%)                                            
      Pars Distalis, Hyperplasia, Focal                1 (2%)                    1 (3%)                                             
      Pars Intermedia, Hyperplasia                                               1 (3%)                                             
   Thyroid Gland                                      (48)         (48)         (48)                                                
      Infiltration Cellular, Lymphocyte                                          1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05030-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             PROBENECID                                        Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 15:09:51  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      .1G/KG       .4G/KG                                                 
                                                    FEMALE       LF           HF                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Follicle, Cyst                                   1 (2%)                    1 (2%)                                             
      Follicular Cell, Hyperplasia                                  1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (47)         (48)         (50)                                                
      Abscess                                          1 (2%)       3 (6%)      11 (22%)                                            
      Angiectasis                                                                2 (4%)                                             
      Cyst                                             4 (9%)       4 (8%)       9 (18%)                                            
      Degeneration, Cystic                            12 (26%)      9 (19%)      7 (14%)                                            
      Hemorrhage                                       2 (4%)       1 (2%)       2 (4%)                                             
      Hyperplasia                                      1 (2%)       1 (2%)                                                          
      Inflammation, Acute                                                        1 (2%)                                             
      Mineralization                                   2 (4%)       1 (2%)                                                          
      Pigmentation                                     3 (6%)       1 (2%)                                                          
      Bilateral, Abscess                                            4 (8%)                                                          
   Uterus                                             (48)         (30)         (50)                                                
      Angiectasis                                                                1 (2%)                                             
      Cyst                                                          1 (3%)                                                          
      Hemorrhage                                       1 (2%)                    1 (2%)                                             
      Hyperplasia                                      1 (2%)                                                                       
      Inflammation, Acute                              1 (2%)       2 (7%)       2 (4%)                                             
      Mineralization                                                             1 (2%)                                             
      Necrosis                                                      1 (3%)       1 (2%)                                             
      Endometrium, Hyperplasia                        36 (75%)     14 (47%)     33 (66%)                                            
   Vagina                                                          (1)          (1)                                                 
      Inflammation, Chronic Active                                               1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (48)         (14)         (49)                                                
      Myelofibrosis                                   13 (27%)                   5 (10%)                                            
   Lymph Node                                         (43)         (26)         (45)                                                
      Hematopoietic Cell Proliferation                                           1 (2%)                                             
      Lumbar, Angiectasis                                           1 (4%)                                                          
      Lumbar, Hematopoietic Cell Proliferation                      3 (12%)      6 (13%)                                            
      Lumbar, Infiltration Cellular, Plasma Cell       1 (2%)       8 (31%)      5 (11%)                                            
      Lumbar, Infiltration Cellular, Histiocyte                     1 (4%)                                                          
      Mandibular, Hematopoietic Cell Proliferation                               2 (4%)                                             
      Mandibular, Infiltration Cellular, Plasma                                                                                     
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05030-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             PROBENECID                                        Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 15:09:51  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      .1G/KG       .4G/KG                                                 
                                                    FEMALE       LF           HF                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
          Cell                                         1 (2%)                                                                       
      Mediastinal, Hematopoietic Cell Proliferation                              1 (2%)                                             
      Mediastinal, Infiltration Cellular, Plasma                                                                                    
          Cell                                                      2 (8%)       1 (2%)                                             
      Pancreatic, Angiectasis                                                    1 (2%)                                             
      Pancreatic, Hematopoietic Cell Proliferation                  1 (4%)       2 (4%)                                             
      Renal, Hematopoietic Cell Proliferation                       2 (8%)       4 (9%)                                             
      Renal, Hemorrhage                                             1 (4%)                                                          
      Renal, Infiltration Cellular, Plasma Cell        1 (2%)       8 (31%)      3 (7%)                                             
      Renal, Infiltration Cellular, Histiocyte                      1 (4%)                                                          
   Lymph Node, Mesenteric                             (41)         (20)         (44)                                                
      Angiectasis                                      4 (10%)                   4 (9%)                                             
      Depletion Lymphoid                                                         1 (2%)                                             
      Hematopoietic Cell Proliferation                 3 (7%)       2 (10%)      7 (16%)                                            
      Hemorrhage                                                    1 (5%)                                                          
      Infiltration Cellular, Plasma Cell               1 (2%)       3 (15%)      2 (5%)                                             
      Infiltration Cellular, Histiocyte                             1 (5%)                                                          
      Necrosis                                                                   1 (2%)                                             
   Spleen                                             (48)         (25)         (49)                                                
      Angiectasis                                                                1 (2%)                                             
      Atrophy                                                                    1 (2%)                                             
      Hematopoietic Cell Proliferation                24 (50%)     15 (60%)     32 (65%)                                            
      Hemorrhage                                                    1 (4%)                                                          
      Necrosis                                         1 (2%)                                                                       
      Thrombosis                                                    1 (4%)                                                          
      Lymphoid Follicle, Hyperplasia                   2 (4%)                    3 (6%)                                             
   Thymus                                             (42)         (12)         (42)                                                
      Angiectasis                                      1 (2%)                                                                       
      Depletion Lymphoid                                                         1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (46)         (16)         (48)                                                
      Bacterium                                                                  1 (2%)                                             
      Cyst Epithelial Inclusion                                                  1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05030-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             PROBENECID                                        Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 15:09:51  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      .1G/KG       .4G/KG                                                 
                                                    FEMALE       LF           HF                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (49)         (23)         (49)                                                
      Bacterium                                                                  2 (4%)                                             
      Congestion                                       1 (2%)                                                                       
      Hemorrhage                                       4 (8%)       1 (4%)       1 (2%)                                             
      Infiltration Cellular, Histiocyte                2 (4%)       1 (4%)       1 (2%)                                             
      Inflammation, Acute                                                        4 (8%)                                             
      Inflammation, Chronic Active                                  2 (9%)                                                          
      Pleura, Abscess                                               2 (9%)                                                          
      Pleura, Inflammation, Acute                                                2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                                 (1)          (2)                                                 
      Mineralization                                                1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (48)         (19)         (49)                                                
      Cyst                                             1 (2%)                                                                       
      Degeneration                                     1 (2%)                                                                       
      Hydronephrosis                                   1 (2%)                                                                       
      Inflammation, Acute                                                        1 (2%)                                             
      Inflammation, Chronic Active                                  1 (5%)                                                          
      Cortex, Mineralization                           1 (2%)       1 (5%)       1 (2%)                                             
      Papilla, Mineralization                          1 (2%)                    2 (4%)                                             
      Renal Tubule, Pigmentation                       1 (2%)                                                                       
      Renal Tubule, Regeneration                       1 (2%)                                                                       
   Urinary Bladder                                    (44)         (13)         (47)                                                
      Edema                                            1 (2%)                                                                       
      Infiltration Cellular, Polymorphonuclear         1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05030-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             PROBENECID                                        Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 15:09:51  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      .1G/KG       .4G/KG                                                 
                                                   MALE          LM           HM                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Dead                                               7            6           13                                                  
    Moribund                                           5           19           13                                                  
    Gavage Death                                                    2                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                38           23           24                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (46)         (40)         (40)                                                
      Hemorrhage                                       1 (2%)                                                                       
   Intestine Large                                    (49)         (49)         (47)                                                
      Anus, Inflammation, Chronic Active                            1 (2%)                                                          
      Anus, Necrosis                                                1 (2%)                                                          
   Intestine Large, Colon                             (49)         (49)         (47)                                                
      Lymphoid Nodule, Hyperplasia                                  2 (4%)                                                          
   Intestine Large, Rectum                            (48)         (45)         (40)                                                
      Inflammation, Acute                                                        1 (3%)                                             
      Necrosis                                                                   1 (3%)                                             
   Intestine Small, Duodenum                          (48)         (45)         (42)                                                
      Necrosis                                                      1 (2%)                                                          
   Intestine Small, Ileum                             (48)         (44)         (43)                                                
      Epithelium, Hyperplasia                          1 (2%)                                                                       
      Lymphoid Nodule, Hyperplasia                     1 (2%)       2 (5%)                                                          
   Intestine Small, Jejunum                           (48)         (43)         (39)                                                
      Lymphoid Nodule, Hyperplasia                                  1 (2%)                                                          
   Liver                                              (50)         (50)         (50)                                                
      Angiectasis                                                                1 (2%)                                             
      Clear Cell Focus                                                           2 (4%)                                             
      Cyst                                                          1 (2%)       1 (2%)                                             
      Fatty Change, Focal                              2 (4%)       1 (2%)       2 (4%)                                             
      Hematopoietic Cell Proliferation                              1 (2%)       1 (2%)                                             
      Hemorrhage                                                                 1 (2%)                                             
      Mineralization                                                             3 (6%)                                             
      Necrosis                                         4 (8%)       8 (16%)     14 (28%)                                            
      Necrosis, Coagulative                                         1 (2%)                                                          
      Pigmentation                                                               2 (4%)                                             
   Mesentery                                          (1)          (2)          (1)                                                 
      Fat, Inflammation, Chronic Active                1 (100%)                                                                     
      Fat, Mineralization                              1 (100%)                                                                     
      Fat, Necrosis                                                 2 (100%)                                                        
   Pancreas                                           (47)         (50)         (50)                                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05030-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             PROBENECID                                        Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 15:09:51  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      .1G/KG       .4G/KG                                                 
                                                   MALE          LM           HM                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Acinus, Atrophy                                  1 (2%)                                                                       
      Acinus, Hypertrophy                                           2 (4%)                                                          
   Stomach                                            (49)         (50)         (48)                                                
      Submucosa, Inflammation, Chronic Active          1 (2%)                                                                       
   Stomach, Forestomach                               (49)         (50)         (48)                                                
      Acanthosis                                       2 (4%)       3 (6%)       7 (15%)                                            
      Acanthosis, Focal                                1 (2%)                    1 (2%)                                             
      Hyperkeratosis                                   7 (14%)      5 (10%)     10 (21%)                                            
      Inflammation, Acute                                           1 (2%)                                                          
      Inflammation, Chronic Active                                               2 (4%)                                             
      Necrosis                                                      3 (6%)       4 (8%)                                             
   Stomach, Glandular                                 (47)         (50)         (45)                                                
      Hyperplasia                                      2 (4%)       1 (2%)       1 (2%)                                             
      Inflammation, Chronic Active                     3 (6%)                                                                       
      Mineralization                                   1 (2%)                                                                       
      Necrosis                                                      2 (4%)       1 (2%)                                             
      Pigmentation                                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (49)         (50)         (50)                                                
      Cardiomyopathy                                   1 (2%)                                                                       
      Inflammation, Acute                                           2 (4%)                                                          
      Inflammation, Chronic Active                     1 (2%)       1 (2%)                                                          
      Mineralization                                                             2 (4%)                                             
      Thrombosis                                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (48)         (50)         (49)                                                
      Capsule, Hyperplasia                            23 (48%)     22 (44%)     30 (61%)                                            
      Capsule, Hyperplasia, Focal                      1 (2%)       2 (4%)                                                          
   Adrenal Gland, Cortex                              (48)         (50)         (49)                                                
      Accessory Adrenal Cortical Nodule                1 (2%)       1 (2%)       1 (2%)                                             
      Hemorrhage                                                    1 (2%)                                                          
      Hyperplasia                                     22 (46%)     23 (46%)     28 (57%)                                            
      Hypertrophy                                                                1 (2%)                                             
   Adrenal Gland, Medulla                             (48)         (44)         (46)                                                
      Hyperplasia                                      7 (15%)     10 (23%)      6 (13%)                                            
   Islets, Pancreatic                                 (47)         (49)         (49)                                                
      Hyperplasia                                      1 (2%)                    2 (4%)                                             
   Parathyroid Gland                                  (31)         (35)         (28)                                                
      Cyst                                                                       1 (4%)                                             
      Hyperplasia                                                                1 (4%)                                             
   Pituitary Gland                                    (38)         (44)         (44)                                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05030-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             PROBENECID                                        Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 15:09:51  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      .1G/KG       .4G/KG                                                 
                                                   MALE          LM           HM                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Pars Distalis, Cyst                                           1 (2%)                                                          
      Pars Distalis, Hyperplasia                                    1 (2%)       1 (2%)                                             
      Pars Distalis, Hyperplasia, Adenomatous          1 (3%)                                                                       
   Thyroid Gland                                      (48)         (50)         (47)                                                
      Cyst                                                                       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (12)         (15)         (21)                                                
      Dilatation                                       5 (42%)      3 (20%)      8 (38%)                                            
      Inflammation, Acute                              1 (8%)                    2 (10%)                                            
      Inflammation, Chronic                                         1 (7%)                                                          
      Inflammation, Chronic Active                     4 (33%)      4 (27%)      5 (24%)                                            
      Necrosis                                         4 (33%)      4 (27%)      4 (19%)                                            
   Prostate                                           (48)         (46)         (50)                                                
      Inflammation, Acute                              2 (4%)       2 (4%)       4 (8%)                                             
      Inflammation, Chronic Active                                  2 (4%)                                                          
      Necrosis                                                      1 (2%)                                                          
      Epithelium, Hyperplasia                                       2 (4%)                                                          
   Seminal Vesicle                                    (49)         (50)         (50)                                                
      Hemorrhage                                       1 (2%)                                                                       
      Inflammation, Acute                              1 (2%)                    2 (4%)                                             
      Inflammation, Chronic Active                                  1 (2%)                                                          
   Testes                                             (49)         (50)         (50)                                                
      Atrophy                                          1 (2%)                                                                       
      Spermatocele                                     1 (2%)                                                                       
      Interstitial Cell, Hyperplasia                                             1 (2%)                                             
      Seminiferous Tubule, Atrophy                     1 (2%)       2 (4%)       2 (4%)                                             
      Seminiferous Tubule, Mineralization              1 (2%)       2 (4%)       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (50)         (50)                                                
      Angiectasis                                                                1 (2%)                                             
   Lymph Node                                         (44)         (45)         (42)                                                
      Axillary, Infiltration Cellular, Plasma Cell     1 (2%)       2 (4%)       1 (2%)                                             
      Axillary, Infiltration Cellular, Lymphocyte      1 (2%)                                                                       
      Inguinal, Infiltration Cellular, Lymphocyte      1 (2%)                                                                       
      Lumbar, Hematopoietic Cell Proliferation                      3 (7%)                                                          
      Lumbar, Hyperplasia, Plasma Cell                              1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05030-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             PROBENECID                                        Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 15:09:51  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      .1G/KG       .4G/KG                                                 
                                                   MALE          LM           HM                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Lumbar, Infiltration Cellular, Plasma Cell       2 (5%)       7 (16%)      2 (5%)                                             
      Lumbar, Infiltration Cellular, Lymphocyte        1 (2%)                                                                       
      Lumbar, Infiltration Cellular, Histiocyte                     1 (2%)                                                          
      Lumbar, Inflammation, Acute                                                1 (2%)                                             
      Mandibular, Necrosis                                                       1 (2%)                                             
      Mediastinal, Angiectasis                                                   1 (2%)                                             
      Mediastinal, Hematopoietic Cell Proliferation                              1 (2%)                                             
      Mediastinal, Infiltration Cellular,                                                                                           
          Histiocyte                                   1 (2%)                                                                       
      Pancreatic, Hematopoietic Cell Proliferation                  1 (2%)                                                          
      Renal, Hematopoietic Cell Proliferation                       1 (2%)                                                          
      Renal, Infiltration Cellular, Plasma Cell        1 (2%)       2 (4%)       3 (7%)                                             
      Renal, Infiltration Cellular, Histiocyte                      2 (4%)                                                          
   Lymph Node, Mesenteric                             (44)         (42)         (38)                                                
      Angiectasis                                     20 (45%)     19 (45%)     14 (37%)                                            
      Hematopoietic Cell Proliferation                 4 (9%)       6 (14%)      9 (24%)                                            
      Necrosis                                                                   1 (3%)                                             
   Spleen                                             (49)         (50)         (48)                                                
      Angiectasis                                                                2 (4%)                                             
      Atrophy                                                                    1 (2%)                                             
      Depletion Lymphoid                                            2 (4%)       1 (2%)                                             
      Fibrosis                                         1 (2%)                                                                       
      Hematopoietic Cell Proliferation                19 (39%)     25 (50%)     29 (60%)                                            
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Necrosis                                                                   1 (2%)                                             
      Lymphoid Follicle, Hyperplasia                   1 (2%)                                                                       
   Thymus                                             (47)         (36)         (36)                                                
      Atrophy                                          1 (2%)       1 (3%)       1 (3%)                                             
      Depletion Lymphoid                                            4 (11%)      2 (6%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (47)         (49)         (48)                                                
      Hemorrhage                                                    1 (2%)                                                          
      Hyperplasia, Basal Cell                          1 (2%)                                                                       
      Inflammation, Acute                                           1 (2%)                                                          
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Necrosis                                         1 (2%)       2 (4%)                                                          
      Inguinal, Fungus                                 1 (2%)                                                                       
      Inguinal, Inflammation, Chronic Active           1 (2%)                                                                       
      Inguinal, Necrosis                               1 (2%)                                                                       
      Prepuce, Acanthosis                                           1 (2%)                                                          
      Prepuce, Hemorrhage                                           1 (2%)       1 (2%)                                             
      Prepuce, Inflammation, Acute                                               1 (2%)                                             
      Prepuce, Inflammation, Chronic Active            2 (4%)       1 (2%)                                                          
      Prepuce, Necrosis                                2 (4%)       3 (6%)       2 (4%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05030-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             PROBENECID                                        Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 15:09:51  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      .1G/KG       .4G/KG                                                 
                                                   MALE          LM           HM                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Subcutaneous Tissue, Mineralization                                        1 (2%)                                             
      Subcutaneous Tissue, Necrosis                                              1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (49)         (50)         (50)                                                
      Joint, Hyperostosis                              1 (2%)                                                                       
      Tarsal, Hyperostosis                            35 (71%)     33 (66%)     36 (72%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (49)         (50)         (50)                                                
      Bacterium                                                                  1 (2%)                                             
      Congestion                                                    2 (4%)       2 (4%)                                             
      Hemorrhage                                       6 (12%)      2 (4%)       4 (8%)                                             
      Infiltration Cellular, Histiocyte                2 (4%)       1 (2%)       2 (4%)                                             
      Inflammation, Acute                              2 (4%)       2 (4%)       2 (4%)                                             
      Necrosis                                                                   1 (2%)                                             
      Pigmentation                                                               1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                 3 (6%)       2 (4%)                                                          
   Nose                                               (40)         (45)         (43)                                                
      Edema                                            1 (3%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (50)         (50)                                                
      Atrophy                                                       1 (2%)                                                          
      Bacterium                                        1 (2%)                                                                       
      Casts Protein                                                 3 (6%)       4 (8%)                                             
      Congestion                                                    1 (2%)       1 (2%)                                             
      Glomerulosclerosis                                                         4 (8%)                                             
      Hydronephrosis                                                1 (2%)       1 (2%)                                             
      Inflammation, Acute                                           4 (8%)       1 (2%)                                             
      Inflammation, Chronic                                                      1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05030-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             PROBENECID                                        Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 15:09:51  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      .1G/KG       .4G/KG                                                 
                                                   MALE          LM           HM                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Inflammation, Chronic Active                                  1 (2%)       1 (2%)                                             
      Cortex, Mineralization                          16 (33%)      4 (8%)       9 (18%)                                            
      Papilla, Mineralization                          2 (4%)                    3 (6%)                                             
      Papilla, Necrosis                                1 (2%)       2 (4%)       1 (2%)                                             
      Renal Tubule, Casts Protein                                   1 (2%)       1 (2%)                                             
      Renal Tubule, Regeneration                       1 (2%)                    4 (8%)                                             
   Urinary Bladder                                    (48)         (49)         (47)                                                
      Calculus Micro Observation Only                  1 (2%)       2 (4%)       2 (4%)                                             
      Inflammation, Acute                                           2 (4%)       3 (6%)                                             
      Inflammation, Chronic Active                                  2 (4%)                                                          
      Mineralization                                   1 (2%)                                                                       
      Necrosis                                                      3 (6%)       1 (2%)                                             
      Transitional Epithelium, Hyperplasia                          2 (4%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
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