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https://ntp.niehs.nih.gov/go/3854

TR 395 Rat Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                             PROBENECID


NTP Experiment-Test: 05030-01                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/04/94
Route: GAVAGE                                                                                                     Time: 13:40:31




       Facility:  TSI Mason Research

       Chemical CAS #:  57-66-9

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05030-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             PROBENECID                                        Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 13:40:31  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      .1G/KG       .4G/KG                                                 
                                                    FEMALE       LF           HF                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund                                          25           15           20                                                  
    Dead                                               1                        10                                                  
    Gavage Death                                                                 1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                23           35           19                                                  
    Moribund                                           1                                                                            
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (48)         (49)         (48)                                                
      Inflammation, Chronic Active                                               1 (2%)                                             
   Intestine Large, Cecum                             (50)         (9)          (44)                                                
      Parasite                                                                   1 (2%)                                             
   Intestine Large, Colon                             (49)         (9)          (48)                                                
      Parasite                                         2 (4%)                    9 (19%)                                            
   Intestine Large, Rectum                            (48)         (8)          (45)                                                
      Parasite                                         1 (2%)       1 (13%)                                                         
   Intestine Small, Ileum                             (49)         (10)         (44)                                                
      Lymphoid Nodule, Hyperplasia                     2 (4%)                    1 (2%)                                             
      Lymphoid Tissue, Hyperplasia                                  1 (10%)                                                         
   Intestine Small, Jejunum                           (48)         (11)         (44)                                                
      Lymphoid Nodule, Hyperplasia                     1 (2%)       1 (9%)       1 (2%)                                             
   Liver                                              (50)         (30)         (50)                                                
      Angiectasis                                      2 (4%)       1 (3%)                                                          
      Basophilic Focus                                35 (70%)     20 (67%)     27 (54%)                                            
      Clear Cell Focus                                              1 (3%)       1 (2%)                                             
      Congestion                                                                 1 (2%)                                             
      Cyst                                             1 (2%)                                                                       
      Fatty Change, Diffuse                            8 (16%)      2 (7%)       1 (2%)                                             
      Fatty Change, Focal                              9 (18%)      7 (23%)      3 (6%)                                             
      Focal Cellular Change                            1 (2%)                                                                       
      Hepatodiaphragmatic Nodule                       4 (8%)       7 (23%)      5 (10%)                                            
      Mixed Cell Focus                                 5 (10%)      2 (7%)       5 (10%)                                            
      Necrosis                                         1 (2%)                    2 (4%)                                             
      Pigmentation                                     2 (4%)       1 (3%)                                                          
      Regeneration, Focal                              1 (2%)                    2 (4%)                                             
      Bile Duct, Hyperplasia                          12 (24%)      7 (23%)      7 (14%)                                            
   Mesentery                                          (6)          (2)          (6)                                                 
      Artery, Pigmentation                             1 (17%)                                                                      
      Artery, Thrombosis                               1 (17%)                                                                      
      Fat, Hemorrhage                                                            1 (17%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05030-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             PROBENECID                                        Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 13:40:31  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      .1G/KG       .4G/KG                                                 
                                                    FEMALE       LF           HF                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Fat, Inflammation, Chronic Active                1 (17%)                                                                      
      Fat, Mineralization                              1 (17%)                   1 (17%)                                            
      Fat, Necrosis                                    4 (67%)      2 (100%)     4 (67%)                                            
      Fat, Pigmentation                                1 (17%)                                                                      
   Pancreas                                           (50)         (14)         (50)                                                
      Acinus, Atrophy                                  1 (2%)                    1 (2%)                                             
      Acinus, Hyperplasia                              2 (4%)                    1 (2%)                                             
      Artery, Pigmentation                             1 (2%)                                                                       
   Salivary Glands                                    (50)         (10)         (48)                                                
      Acinus, Hypertrophy                              2 (4%)                                                                       
      Acinus, Inflammation, Chronic Active             1 (2%)                    1 (2%)                                             
      Acinus, Necrosis                                 2 (4%)                                                                       
      Duct, Inflammation, Acute                                     1 (10%)                                                         
      Duct, Inflammation, Chronic Active               5 (10%)                   1 (2%)                                             
      Duct, Metaplasia, Squamous                      18 (36%)      2 (20%)     13 (27%)                                            
      Duct, Mineralization                                                       1 (2%)                                             
   Stomach, Forestomach                               (49)         (9)          (49)                                                
      Acanthosis                                       2 (4%)                    1 (2%)                                             
      Hemorrhage                                                                 1 (2%)                                             
      Hyperkeratosis                                   2 (4%)       1 (11%)                                                         
      Inflammation, Chronic Active                                               1 (2%)                                             
      Necrosis                                         2 (4%)                                                                       
   Stomach, Glandular                                 (50)         (9)          (47)                                                
      Hyperplasia                                                   1 (11%)                                                         
      Mineralization                                   1 (2%)                                                                       
      Necrosis                                                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                                                 (1)                                                 
      Artery, Inflammation, Chronic Active                                       1 (100%)                                           
   Heart                                              (50)         (9)          (50)                                                
      Cardiomyopathy                                  32 (64%)      3 (33%)     31 (62%)                                            
      Mineralization                                                1 (11%)      1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (13)         (49)                                                
      Congestion                                                                 1 (2%)                                             
      Hemorrhage                                                                 1 (2%)                                             
      Vacuolization Cytoplasmic                        1 (2%)                    2 (4%)                                             
   Adrenal Gland, Medulla                             (48)         (13)         (45)                                                
      Hyperplasia                                      5 (10%)      1 (8%)       6 (13%)                                            
   Islets, Pancreatic                                 (50)         (11)         (50)                                                
      Hyperplasia                                      1 (2%)                    1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05030-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             PROBENECID                                        Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 13:40:31  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      .1G/KG       .4G/KG                                                 
                                                    FEMALE       LF           HF                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
   Pituitary Gland                                    (50)         (50)         (50)                                                
      Pars Distalis, Angiectasis                      24 (48%)     24 (48%)     15 (30%)                                            
      Pars Distalis, Cyst                              7 (14%)      3 (6%)       4 (8%)                                             
      Pars Distalis, Hyperplasia                      15 (30%)     13 (26%)     11 (22%)                                            
      Pars Intermedia, Angiectasis                                               1 (2%)                                             
      Pars Intermedia, Hyperplasia                     1 (2%)                    1 (2%)                                             
      Pars Nervosa, Cyst                                            1 (2%)                                                          
   Thyroid Gland                                      (49)         (50)         (47)                                                
      Mineralization                                                             1 (2%)                                             
      C-Cell, Hyperplasia                              8 (16%)     13 (26%)      4 (9%)                                             
      Follicular Cell, Hyperplasia                                               2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)                                                                           
      Abscess                                          1 (100%)                                                                     
      Mineralization                                   1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (36)         (16)         (45)                                                
      Hyperplasia                                                   1 (6%)                                                          
      Inflammation, Acute                                           3 (19%)                                                         
      Inflammation, Chronic Active                                               1 (2%)                                             
      Necrosis                                                      1 (6%)       1 (2%)                                             
   Ovary                                              (50)         (16)         (50)                                                
      Cyst                                             2 (4%)       1 (6%)       4 (8%)                                             
      Pigmentation                                                               1 (2%)                                             
   Uterus                                             (50)         (16)         (49)                                                
      Cyst                                             1 (2%)                                                                       
      Decidual Reaction                                                          1 (2%)                                             
      Hemorrhage                                                                 1 (2%)                                             
      Bilateral, Abscess                                                         1 (2%)                                             
      Endometrium, Hyperplasia, Adenomatous                                      1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (8)          (50)                                                
      Hypoplasia                                       1 (2%)                                                                       
   Lymph Node                                         (49)         (21)         (50)                                                
      Lumbar, Infiltration Cellular, Plasma Cell                    1 (5%)                                                          
      Mandibular, Hematopoietic Cell Proliferation                               1 (2%)                                             
      Mandibular, Infiltration Cellular, Plasma                                                                                     
          Cell                                                      1 (5%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05030-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             PROBENECID                                        Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 13:40:31  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      .1G/KG       .4G/KG                                                 
                                                    FEMALE       LF           HF                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Mediastinal, Angiectasis                         2 (4%)                                                                       
      Mediastinal, Infiltration Cellular, Plasma                                                                                    
          Cell                                         1 (2%)       1 (5%)                                                          
      Mediastinal, Infiltration Cellular,                                                                                           
          Histiocyte                                   3 (6%)                    3 (6%)                                             
      Pancreatic, Depletion Lymphoid                   1 (2%)                                                                       
      Pancreatic, Hematopoietic Cell Proliferation     1 (2%)                                                                       
      Pancreatic, Infiltration Cellular, Histiocyte    2 (4%)       1 (5%)       2 (4%)                                             
      Renal, Angiectasis                               3 (6%)                                                                       
      Renal, Infiltration Cellular, Histiocyte         4 (8%)       2 (10%)      2 (4%)                                             
   Lymph Node, Mesenteric                             (49)         (20)         (50)                                                
      Angiectasis                                      2 (4%)       2 (10%)      1 (2%)                                             
      Depletion Lymphoid                               1 (2%)       1 (5%)       1 (2%)                                             
      Infiltration Cellular, Mast Cell                                           1 (2%)                                             
      Infiltration Cellular, Histiocyte                1 (2%)       7 (35%)      7 (14%)                                            
   Spleen                                             (50)         (23)         (50)                                                
      Angiectasis                                                   1 (4%)                                                          
      Depletion Lymphoid                               3 (6%)       1 (4%)       5 (10%)                                            
      Fibrosis                                         1 (2%)                                                                       
      Hematopoietic Cell Proliferation                38 (76%)      6 (26%)     23 (46%)                                            
      Hemorrhage                                       2 (4%)       1 (4%)       1 (2%)                                             
      Infiltration Cellular, Histiocyte                9 (18%)      2 (9%)      15 (30%)                                            
      Necrosis                                         2 (4%)       1 (4%)       1 (2%)                                             
      Pigmentation                                                  4 (17%)                                                         
   Thymus                                             (49)         (10)         (46)                                                
      Cyst                                                                       1 (2%)                                             
      Depletion Lymphoid                               2 (4%)       1 (10%)      1 (2%)                                             
      Hemorrhage                                                                 2 (4%)                                             
      Necrosis                                                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (47)         (28)         (36)                                                
      Galactocele                                     36 (77%)     13 (46%)      6 (17%)                                            
      Acinus, Hyperplasia                              1 (2%)       1 (4%)       1 (3%)                                             
   Skin                                               (50)         (12)         (49)                                                
      Acanthosis                                                    1 (8%)                                                          
      Cyst Epithelial Inclusion                                                  1 (2%)                                             
      Hyperkeratosis                                                1 (8%)       1 (2%)                                             
      Necrosis                                                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05030-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             PROBENECID                                        Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 13:40:31  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      .1G/KG       .4G/KG                                                 
                                                    FEMALE       LF           HF                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (1)                                                                           
      Artery, Pigmentation                             1 (100%)                                                                     
      Artery, Thrombosis                               1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (10)         (50)                                                
      Hemorrhage                                                                 1 (2%)                                             
      Inflammation, Acute                                           1 (10%)                                                         
      Brain Stem, Hemorrhage                           1 (2%)                                                                       
      Cerebrum, Hemorrhage                                                       1 (2%)                                             
      Cerebrum, Necrosis                               2 (4%)                                                                       
      Medulla, Hemorrhage                              1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (26)         (50)                                                
      Atelectasis                                                                1 (2%)                                             
      Congestion                                       6 (12%)     10 (38%)      5 (10%)                                            
      Edema                                                                      8 (16%)                                            
      Embolus Tumor                                    1 (2%)                                                                       
      Fibrosis                                                                   1 (2%)                                             
      Hemorrhage                                       2 (4%)       2 (8%)       5 (10%)                                            
      Infiltration Cellular, Histiocyte                3 (6%)                    6 (12%)                                            
      Inflammation, Chronic Active                                  1 (4%)       3 (6%)                                             
      Mineralization                                                             1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                 2 (4%)       2 (8%)       3 (6%)                                             
      Mediastinum, Atypia Cellular                     1 (2%)                                                                       
   Nose                                               (49)         (9)          (50)                                                
      Inflammation, Chronic Active                     1 (2%)                    2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (11)         (13)         (6)                                                 
      Hemorrhage                                       1 (9%)                                                                       
      Synechia                                                      2 (15%)      1 (17%)                                            
      Lens, Cataract                                   3 (27%)      4 (31%)      3 (50%)                                            
      Retina, Atrophy                                               2 (15%)      1 (17%)                                            
   Harderian Gland                                    (6)          (5)          (7)                                                 
      Hyperplasia                                      2 (33%)                                                                      
      Inflammation, Chronic Active                     1 (17%)                                                                      
      Pigmentation                                     2 (33%)      1 (20%)      1 (14%)                                            
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05030-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             PROBENECID                                        Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 13:40:31  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      .1G/KG       .4G/KG                                                 
                                                    FEMALE       LF           HF                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Atrophy                                          1 (2%)                                                                       
      Cyst                                                                       1 (2%)                                             
      Hydronephrosis                                   1 (2%)                                                                       
      Nephropathy                                     41 (82%)     33 (66%)     30 (60%)                                            
      Pigmentation                                                  1 (2%)                                                          
      Cortex, Inflammation, Acute                                                1 (2%)                                             
      Cortex, Mineralization                           4 (8%)       3 (6%)      10 (20%)                                            
      Papilla, Mineralization                         18 (36%)     10 (20%)     24 (48%)                                            
      Papilla, Necrosis                                                          1 (2%)                                             
      Pelvis, Mineralization                          43 (86%)     30 (60%)     30 (60%)                                            
      Renal Tubule, Pigmentation                      48 (96%)     47 (94%)     46 (92%)                                            
   Urinary Bladder                                    (50)         (8)          (47)                                                
      Hemorrhage                                       2 (4%)                    1 (2%)                                             
      Inflammation, Acute                              1 (2%)                                                                       
      Mineralization                                                1 (13%)                                                         
      Necrosis                                                                   1 (2%)                                             
      Transitional Epithelium, Hyperplasia                                       1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05030-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             PROBENECID                                        Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 13:40:31  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      .1G/KG       .4G/KG                                                 
                                                   MALE          LM           HM                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund                                          10           11           22                                                  
    Dead                                               3            4            5                                                  
    Gavage Death                                                    1            1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                34           32           21                                                  
    Moribund                                           2            2            1                                                  
    Dead                                               1                                                                            
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (48)         (12)         (48)                                                
      Hyperkeratosis                                                             1 (2%)                                             
      Necrosis                                                      1 (8%)                                                          
   Intestine Large, Cecum                             (48)         (7)          (48)                                                
      Inflammation, Chronic Active                                               1 (2%)                                             
      Lymphoid Nodule, Hyperplasia                                               1 (2%)                                             
   Intestine Large, Colon                             (47)         (8)          (48)                                                
      Parasite                                         3 (6%)                    6 (13%)                                            
   Intestine Large, Rectum                            (46)         (9)          (48)                                                
      Parasite                                                      1 (11%)      1 (2%)                                             
   Intestine Small, Ileum                             (47)         (8)          (47)                                                
      Lymphoid Nodule, Hyperplasia                                               1 (2%)                                             
      Lymphoid Tissue, Hyperplasia                                  1 (13%)                                                         
   Intestine Small, Jejunum                           (46)         (8)          (47)                                                
      Hemorrhage                                                    1 (13%)                                                         
      Inflammation, Chronic Active                                               1 (2%)                                             
   Liver                                              (50)         (41)         (50)                                                
      Basophilic Focus                                32 (64%)     27 (66%)     34 (68%)                                            
      Clear Cell Focus                                 1 (2%)      11 (27%)      1 (2%)                                             
      Congestion                                       1 (2%)       1 (2%)                                                          
      Cyst                                                          1 (2%)                                                          
      Degeneration                                                  1 (2%)                                                          
      Degeneration, Cystic                                          1 (2%)                                                          
      Eosinophilic Focus                                                         1 (2%)                                             
      Fatty Change, Diffuse                            8 (16%)      4 (10%)      1 (2%)                                             
      Fatty Change, Focal                             27 (54%)     14 (34%)     14 (28%)                                            
      Focal Cellular Change                                                      2 (4%)                                             
      Hepatodiaphragmatic Nodule                       3 (6%)       6 (15%)      3 (6%)                                             
      Mixed Cell Focus                                 2 (4%)       2 (5%)       1 (2%)                                             
      Necrosis                                         1 (2%)                    2 (4%)                                             
      Regeneration, Focal                              1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05030-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             PROBENECID                                        Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 13:40:31  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      .1G/KG       .4G/KG                                                 
                                                   MALE          LM           HM                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Artery, Inflammation, Chronic Active             1 (2%)                                                                       
      Bile Duct, Hyperplasia                          35 (70%)     25 (61%)     37 (74%)                                            
   Mesentery                                          (9)          (4)          (5)                                                 
      Artery, Necrosis, Fibrinoid                      2 (22%)                                                                      
      Fat, Inflammation, Chronic Active                                          2 (40%)                                            
      Fat, Necrosis                                    4 (44%)      1 (25%)      1 (20%)                                            
      Fat, Pigmentation                                                          1 (20%)                                            
   Pancreas                                           (50)         (20)         (49)                                                
      Acinus, Atrophy                                  2 (4%)       1 (5%)       1 (2%)                                             
      Acinus, Hyperplasia                              7 (14%)      2 (10%)      6 (12%)                                            
      Artery, Mineralization                                        1 (5%)                                                          
      Artery, Necrosis, Fibrinoid                      2 (4%)       1 (5%)                                                          
   Pharynx                                                         (1)                                                              
      Hyperplasia, Pseudoepitheliomatous                            1 (100%)                                                        
   Salivary Glands                                    (49)         (16)         (49)                                                
      Fibrosis                                                      1 (6%)                                                          
      Hyperplasia                                                   1 (6%)                                                          
      Acinus, Inflammation, Chronic Active             1 (2%)                                                                       
      Artery, Necrosis, Fibrinoid                      1 (2%)                                                                       
      Duct, Inflammation, Acute                                     1 (6%)                                                          
      Duct, Inflammation, Chronic Active               3 (6%)                    1 (2%)                                             
      Duct, Metaplasia                                              1 (6%)       1 (2%)                                             
      Duct, Metaplasia, Squamous                      11 (22%)      5 (31%)     10 (20%)                                            
   Stomach, Forestomach                               (50)         (12)         (50)                                                
      Acanthosis                                       2 (4%)       3 (25%)      6 (12%)                                            
      Hyperkeratosis                                   3 (6%)       3 (25%)      5 (10%)                                            
      Hyperplasia, Basal Cell                                       1 (8%)                                                          
      Inflammation, Chronic Active                     1 (2%)       1 (8%)       1 (2%)                                             
      Mineralization                                                1 (8%)                                                          
      Necrosis                                         2 (4%)       1 (8%)       2 (4%)                                             
      Artery, Necrosis, Fibrinoid                      1 (2%)                                                                       
   Stomach, Glandular                                 (49)         (11)         (49)                                                
      Hyperplasia                                                                1 (2%)                                             
      Mineralization                                                             1 (2%)                                             
      Necrosis                                                                   1 (2%)                                             
      Artery, Necrosis, Fibrinoid                      1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (1)                                                                           
      Artery, Necrosis, Fibrinoid                      1 (100%)                                                                     
   Heart                                              (50)         (8)          (50)                                                
      Cardiomyopathy                                  37 (74%)      8 (100%)    44 (88%)                                            
      Thrombosis                                       1 (2%)                                                                       
      Artery, Necrosis, Fibrinoid                      1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05030-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             PROBENECID                                        Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 13:40:31  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      .1G/KG       .4G/KG                                                 
                                                   MALE          LM           HM                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (49)         (50)         (50)                                                
      Accessory Adrenal Cortical Nodule                             1 (2%)                                                          
   Adrenal Gland, Cortex                              (49)         (50)         (50)                                                
      Hemorrhage                                       1 (2%)       1 (2%)                                                          
      Hyperplasia                                                   3 (6%)                                                          
      Vacuolization Cytoplasmic                                                  1 (2%)                                             
   Adrenal Gland, Medulla                             (49)         (50)         (50)                                                
      Hyperplasia                                      9 (18%)     15 (30%)     14 (28%)                                            
   Islets, Pancreatic                                 (49)         (19)         (49)                                                
      Hyperplasia                                      4 (8%)       1 (5%)       1 (2%)                                             
   Parathyroid Gland                                  (42)         (11)         (42)                                                
      Hyperplasia                                      1 (2%)                                                                       
   Pituitary Gland                                    (50)         (26)         (50)                                                
      Pars Distalis, Angiectasis                       9 (18%)     11 (42%)      9 (18%)                                            
      Pars Distalis, Cyst                                           1 (4%)                                                          
      Pars Distalis, Hemorrhage                        1 (2%)                    1 (2%)                                             
      Pars Distalis, Hyperplasia                      11 (22%)      6 (23%)      7 (14%)                                            
      Pars Distalis, Necrosis                                                    1 (2%)                                             
      Pars Distalis, Pigmentation                                   1 (4%)                                                          
      Pars Intermedia, Angiectasis                                  2 (8%)                                                          
      Pars Intermedia, Hyperplasia                                               1 (2%)                                             
   Thyroid Gland                                      (49)         (12)         (49)                                                
      Hemorrhage                                                                 1 (2%)                                             
      C-Cell, Hyperplasia                              7 (14%)      1 (8%)      10 (20%)                                            
      Capsule, Necrosis, Fibrinoid                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (49)         (26)         (48)                                                
      Fibrosis                                                                   1 (2%)                                             
      Inflammation, Chronic Active                     1 (2%)                    1 (2%)                                             
      Spermatocele                                                               2 (4%)                                             
   Preputial Gland                                    (49)         (15)         (50)                                                
      Cyst                                             1 (2%)                                                                       
      Inflammation, Chronic Active                     2 (4%)       1 (7%)       1 (2%)                                             
      Necrosis                                         7 (14%)                   7 (14%)                                            
   Prostate                                           (49)         (10)         (50)                                                
      Inflammation, Chronic Active                     5 (10%)      2 (20%)      3 (6%)                                             
      Artery, Necrosis, Fibrinoid                      1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05030-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             PROBENECID                                        Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 13:40:31  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      .1G/KG       .4G/KG                                                 
                                                   MALE          LM           HM                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Epithelium, Hyperplasia                          2 (4%)                    3 (6%)                                             
   Seminal Vesicle                                    (49)         (30)         (50)                                                
      Concretion                                                    3 (10%)                                                         
   Testes                                             (49)         (44)         (50)                                                
      Atrophy                                                                    1 (2%)                                             
      Congestion                                                                 1 (2%)                                             
      Interstitial Cell, Hyperplasia                  17 (35%)     20 (45%)     26 (52%)                                            
      Seminiferous Tubule, Atrophy                    37 (76%)     25 (57%)     32 (64%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (50)         (27)         (48)                                                
      Iliac, Infiltration Cellular, Histiocyte                                   1 (2%)                                             
      Lumbar, Angiectasis                                           1 (4%)                                                          
      Lumbar, Hematopoietic Cell Proliferation                                   1 (2%)                                             
      Lumbar, Hemorrhage                                                         2 (4%)                                             
      Lumbar, Infiltration Cellular, Histiocyte                     1 (4%)       2 (4%)                                             
      Lumbar, Pigmentation                                          1 (4%)                                                          
      Mandibular, Angiectasis                                       1 (4%)                                                          
      Mandibular, Necrosis                                                       1 (2%)                                             
      Mediastinal, Angiectasis                         1 (2%)       1 (4%)       4 (8%)                                             
      Mediastinal, Depletion Lymphoid                                            1 (2%)                                             
      Mediastinal, Infiltration Cellular,                                                                                           
          Histiocyte                                   5 (10%)      2 (7%)       4 (8%)                                             
      Mediastinal, Pigmentation                                     4 (15%)                                                         
      Pancreatic, Infiltration Cellular, Histiocyte                 2 (7%)       1 (2%)                                             
      Pancreatic, Pigmentation                                      6 (22%)                                                         
      Renal, Angiectasis                               2 (4%)       1 (4%)       2 (4%)                                             
      Renal, Depletion Lymphoid                        1 (2%)                                                                       
      Renal, Hemorrhage                                                          1 (2%)                                             
      Renal, Infiltration Cellular, Histiocyte         4 (8%)       2 (7%)      11 (23%)                                            
      Renal, Pigmentation                                           4 (15%)                                                         
   Lymph Node, Mesenteric                             (50)         (20)         (47)                                                
      Angiectasis                                      1 (2%)       2 (10%)      5 (11%)                                            
      Depletion Lymphoid                                                         2 (4%)                                             
      Hemorrhage                                       1 (2%)                                                                       
      Infiltration Cellular, Mast Cell                                           1 (2%)                                             
      Infiltration Cellular, Histiocyte                             4 (20%)     18 (38%)                                            
      Pigmentation                                                  9 (45%)                                                         
      Renal, Angiectasis                                                         1 (2%)                                             
   Spleen                                             (50)         (19)         (49)                                                
      Congestion                                                    1 (5%)                                                          
      Depletion Lymphoid                               1 (2%)       1 (5%)       2 (4%)                                             
      Fibrosis                                                      1 (5%)       1 (2%)                                             
      Hematopoietic Cell Proliferation                27 (54%)      9 (47%)     38 (78%)                                            
      Hemorrhage                                                    1 (5%)       1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05030-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             PROBENECID                                        Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 13:40:31  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      .1G/KG       .4G/KG                                                 
                                                   MALE          LM           HM                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Infiltration Cellular, Histiocyte                1 (2%)                    3 (6%)                                             
      Necrosis                                         2 (4%)       1 (5%)                                                          
      Pigmentation                                                               1 (2%)                                             
      Capsule, Fibrosis                                1 (2%)                                                                       
      Capsule, Inflammation, Chronic Active            1 (2%)                                                                       
   Thymus                                             (46)         (14)         (46)                                                
      Atrophy                                          1 (2%)                    1 (2%)                                             
      Depletion Lymphoid                                                         1 (2%)                                             
      Epithelial Cell, Hyperplasia                     2 (4%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (26)         (9)          (27)                                                
      Galactocele                                      7 (27%)      3 (33%)      5 (19%)                                            
      Acinus, Hyperplasia                                                        1 (4%)                                             
   Skin                                               (49)         (20)         (50)                                                
      Abscess                                                                    1 (2%)                                             
      Cyst Epithelial Inclusion                        2 (4%)       1 (5%)       1 (2%)                                             
      Fibrosis                                                                   1 (2%)                                             
      Hyperkeratosis                                   4 (8%)       3 (15%)      4 (8%)                                             
      Hyperplasia, Basal Cell                                       1 (5%)       1 (2%)                                             
      Inflammation, Acute                                                        1 (2%)                                             
      Necrosis                                         1 (2%)                    3 (6%)                                             
      Pigmentation                                                  1 (5%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (8)          (50)                                                
      Artery, Necrosis, Fibrinoid                      1 (2%)                                                                       
      Brain Stem, Hemorrhage                           1 (2%)                                                                       
      Cerebellum, Hemorrhage                                        1 (13%)      1 (2%)                                             
      Cerebellum, Necrosis                                          1 (13%)                                                         
      Cerebrum, Hemorrhage                                          1 (13%)      1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05030-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             PROBENECID                                        Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 13:40:31  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      .1G/KG       .4G/KG                                                 
                                                   MALE          LM           HM                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (18)         (50)                                                
      Atelectasis                                                                1 (2%)                                             
      Bronchiectasis                                   1 (2%)                                                                       
      Congestion                                       3 (6%)       4 (22%)      4 (8%)                                             
      Edema                                            1 (2%)       2 (11%)      3 (6%)                                             
      Hemorrhage                                                    3 (17%)      6 (12%)                                            
      Infiltration Cellular, Histiocyte                4 (8%)                    5 (10%)                                            
      Inflammation, Acute                                           1 (6%)                                                          
      Inflammation, Chronic Active                     2 (4%)                    1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                 2 (4%)       3 (17%)      2 (4%)                                             
      Artery, Necrosis, Fibrinoid                      1 (2%)                                                                       
      Bronchiole, Metaplasia, Squamous                 1 (2%)                                                                       
   Nose                                               (49)         (9)          (49)                                                
      Congestion                                                    1 (11%)                                                         
      Inflammation, Chronic Active                     1 (2%)       1 (11%)      7 (14%)                                            
   Trachea                                            (50)         (18)         (50)                                                
      Erosion                                                                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (1)          (3)          (3)                                                 
      Hemorrhage                                                                 1 (33%)                                            
      Necrosis                                                                   1 (33%)                                            
   Eye                                                (5)          (8)          (11)                                                
      Hemorrhage                                                    1 (13%)                                                         
      Synechia                                                      1 (13%)      2 (18%)                                            
      Lens, Cataract                                   1 (20%)      3 (38%)      3 (27%)                                            
      Retina, Atrophy                                                            3 (27%)                                            
      Retina, Hemorrhage                               1 (20%)                                                                      
      Sclera, Pigmentation                                                       1 (9%)                                             
   Harderian Gland                                    (4)          (7)          (4)                                                 
      Hyperplasia                                                                1 (25%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Congestion                                                                 2 (4%)                                             
      Cyst                                                          1 (2%)       1 (2%)                                             
      Hydronephrosis                                                1 (2%)                                                          
      Nephropathy                                     48 (96%)     48 (96%)     47 (94%)                                            
      Artery, Inflammation                             1 (2%)                                                                       
      Cortex, Mineralization                           2 (4%)       9 (18%)      2 (4%)                                             
      Papilla, Mineralization                         32 (64%)     31 (62%)     35 (70%)                                            
      Pelvis, Mineralization                           4 (8%)      12 (24%)     13 (26%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05030-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             PROBENECID                                        Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 13:40:31  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      .1G/KG       .4G/KG                                                 
                                                   MALE          LM           HM                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Pelvis, Transitional Epithelium, Hyperplasia     1 (2%)                                                                       
      Renal Tubule, Degeneration                                    1 (2%)                                                          
      Renal Tubule, Hyperplasia                        3 (6%)                                                                       
      Renal Tubule, Mineralization                                               3 (6%)                                             
      Renal Tubule, Pigmentation                      46 (92%)     46 (92%)     46 (92%)                                            
   Urinary Bladder                                    (48)         (10)         (47)                                                
      Calculus Gross Observation                       2 (4%)       2 (20%)                                                         
      Calculus Micro Observation Only                  3 (6%)       2 (20%)      1 (2%)                                             
      Hemorrhage                                                    1 (10%)                                                         
      Necrosis                                                      1 (10%)                                                         
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
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