TR 396 Mouse Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
MONOCHLOROACETIC ACID
NTP Experiment-Test: 05705-01 Report: PEIRPT03
Study Type: CHRONIC Date: 09/18/94
Route: GAVAGE Time: 19:48:25
Facility: International Research and Development Corp.
Chemical CAS #: 79-11-8
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05705-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 09/18/94
Route: GAVAGE Time: 19:48:25
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 50 MG/KG 100MG/KG
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60
Early Deaths
Dead 9 12 9
Moribund 8 8 4
Dosing Accident 1 3
Survivors
Terminal Sacrifice 41 40 44
Dead 1
Animals Examined Microscopically 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (55) (1) (51)
Calculus Micro Observation Only 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Epithelium, Hyperplasia 1 (2%)
Intestine Large, Colon (59) (60)
Parasite Metazoan 6 (10%) 3 (5%)
Intestine Large, Rectum (60) (58)
Hemorrhage 2 (3%)
Inflammation, Acute, Focal 1 (2%)
Ulcer, Acute 1 (2%)
Intestine Small, Ileum (52) (54)
Amyloid Deposition 1 (2%) 1 (2%)
Congestion 1 (2%)
Inflammation, Acute 1 (2%)
Intestine Small, Jejunum (52) (1) (54)
Ulcer, Acute 1 (2%)
Peyer's Patch, Hyperplasia, Lymphoid 1 (2%) 1 (100%)
Liver (60) (60) (60)
Basophilic Focus 1 (2%)
Hematopoietic Cell Proliferation Granulocytic 1 (2%) 5 (8%)
Inflammation, Acute 1 (2%) 1 (2%) 1 (2%)
Inflammation, Chronic 6 (10%) 17 (28%) 14 (23%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Necrosis, Coagulative 3 (5%) 1 (2%)
Pigmentation 1 (2%)
Bile Duct, Hyperplasia 1 (2%)
Hepatocyte, Necrosis 1 (2%)
Mesentery (23) (7) (16)
Inflammation, Acute 1 (6%)
Inflammation, Chronic 11 (48%) 2 (29%) 8 (50%)
Artery, Adventitia, Inflammation, Chronic
Active 1 (14%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05705-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 09/18/94
Route: GAVAGE Time: 19:48:25
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 50 MG/KG 100MG/KG
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Pancreas (60) (60)
Atrophy 2 (3%) 4 (7%)
Clear Cell Focus 1 (2%)
Inflammation, Chronic 1 (2%) 5 (8%)
Duct, Cyst 2 (3%) 2 (3%)
Salivary Glands (59) (60)
Inflammation, Chronic 3 (5%)
Mucocele 1 (2%)
Stomach, Forestomach (60) (59) (60)
Cyst 1 (2%)
Diverticulum 1 (2%)
Hyperkeratosis 4 (7%)
Hyperplasia, Diffuse, Squamous 1 (2%)
Hyperplasia, Focal, Squamous 5 (8%) 8 (14%) 12 (20%)
Hyperplasia, Multifocal, Squamous 3 (5%)
Inflammation, Acute 1 (2%)
Inflammation, Acute, Multifocal 1 (2%)
Inflammation, Chronic 3 (5%) 3 (5%)
Ulcer 2 (3%) 2 (3%)
Ulcer, Multifocal 1 (2%) 1 (2%)
Vein, Dilatation 1 (2%)
Stomach, Glandular (57) (60) (60)
Erosion 3 (5%) 2 (3%) 2 (3%)
Hyperplasia, Atypical, Focal 1 (2%)
Hyperplasia, Cystic 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%)
Mineralization 1 (2%)
Tooth (2) (2)
Developmental Malformation 1 (50%)
Peridontal Tissue, Cyst 1 (50%)
Peridontal Tissue, Inflammation, Acute 1 (50%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (57) (1) (60)
Inflammation, Acute 1 (2%)
Inflammation, Chronic Active 1 (100%)
Heart (60) (60) (60)
Degeneration 3 (5%) 2 (3%) 5 (8%)
Inflammation, Chronic 1 (2%)
Mineralization 1 (2%) 3 (5%)
Coronary Artery, Inflammation, Chronic 1 (2%)
Valve, Pigmentation 8 (13%) 20 (33%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05705-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 09/18/94
Route: GAVAGE Time: 19:48:25
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 50 MG/KG 100MG/KG
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (59) (1) (60)
Angiectasis 1 (2%)
Basophilic Focus 1 (2%)
Fibrosis, Focal 1 (2%)
Hematopoietic Cell Proliferation Granulocytic 1 (2%) 4 (7%)
Hemorrhage 1 (2%)
Hyperplasia 1 (2%)
Hypertrophy 4 (7%)
Inflammation, Chronic 1 (2%)
Necrosis 1 (2%) 2 (3%)
Subcapsular, Hyperplasia 59 (100%) 58 (97%)
Adrenal Gland, Medulla (57) (59)
Hyperplasia, Focal 1 (2%)
Parathyroid Gland (34) (43)
Cyst 1 (2%)
Pituitary Gland (55) (6) (57)
Cyst 5 (9%) 3 (5%)
Hyperplasia, Focal 16 (29%) 9 (16%)
Hypertrophy, Focal 1 (2%)
Thyroid Gland (60) (1) (60)
Cyst 1 (2%)
Inflammation, Acute, Focal 1 (2%)
Inflammation, Chronic 2 (3%) 2 (3%)
Pigmentation, Cholesterol 1 (2%)
Follicle, Cyst 9 (15%) 2 (3%)
Follicular Cell, Hyperplasia 1 (2%) 5 (8%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (2)
Cyst 1 (50%)
Ovary (59) (24) (60)
Abscess 3 (5%)
Cyst 24 (41%) 12 (50%) 25 (42%)
Cyst, Multiple 11 (19%) 6 (25%) 10 (17%)
Inflammation, Acute 1 (4%) 1 (2%)
Inflammation, Chronic 2 (3%)
Mineralization 1 (2%) 1 (4%) 2 (3%)
Artery, Amyloid Deposition 1 (2%)
Uterus (60) (43) (60)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05705-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 09/18/94
Route: GAVAGE Time: 19:48:25
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 50 MG/KG 100MG/KG
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Abscess 2 (3%)
Inflammation, Acute 3 (7%) 2 (3%)
Thrombosis 1 (2%)
Endometrium, Hyperplasia, Cystic 56 (93%) 41 (95%) 45 (75%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (21) (60)
Myelofibrosis 26 (43%) 21 (100%) 22 (37%)
Myeloid Cell, Hyperplasia 3 (5%) 4 (7%)
Lymph Node (60) (19) (58)
Iliac, Fibrosis 1 (2%)
Iliac, Hematopoietic Cell Proliferation
Granulocytic 1 (2%)
Iliac, Hyperplasia, Plasma Cell 1 (2%) 1 (5%)
Iliac, Inflammation, Acute 1 (2%) 1 (2%)
Iliac, Inflammation, Chronic Active 1 (2%)
Iliac, Pigmentation 1 (2%)
Inguinal, Inflammation, Acute 1 (2%)
Mandibular, Abscess 1 (2%)
Mandibular, Hyperplasia, Lymphoid 2 (3%) 1 (2%)
Mediastinal, Hemorrhage 1 (2%)
Mediastinal, Hyperplasia, Lymphoid 1 (2%)
Mediastinal, Hyperplasia, Plasma Cell 1 (5%)
Pancreatic, Inflammation, Acute 1 (2%)
Renal, Inflammation, Acute 2 (3%)
Lymph Node, Mesenteric (60) (12) (58)
Hematopoietic Cell Proliferation Granulocytic 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia, Lymphoid 3 (5%) 1 (2%)
Inflammation, Acute 1 (2%)
Inflammation, Granulomatous 1 (2%)
Spleen (60) (25) (60)
Fibrosis 2 (8%)
Granuloma, Multiple 1 (2%)
Hematopoietic Cell Proliferation Granulocytic 3 (5%) 2 (8%) 5 (8%)
Hematopoietic Cell Proliferation Erythrocytic 2 (3%) 1 (4%) 3 (5%)
Hyperplasia, Lymphoid 9 (15%) 4 (16%) 17 (28%)
Hyperplasia, Plasma Cell 1 (2%) 1 (2%)
Inflammation, Granulomatous 1 (2%)
Pigmentation 1 (4%)
Thymus (54) (3) (53)
Abscess, Multifocal 1 (2%)
Atrophy 5 (9%) 2 (4%)
Cyst 8 (15%) 1 (33%) 9 (17%)
Hyperplasia, Lymphoid 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05705-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 09/18/94
Route: GAVAGE Time: 19:48:25
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 50 MG/KG 100MG/KG
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Inflammation, Acute 1 (2%)
Necrosis 2 (4%)
Pigmentation, Lipofuscin 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (59) (4) (60)
Fibrosis, Focal 1 (2%)
Hemorrhage 1 (2%)
Inflammation, Chronic 4 (7%)
Acinus, Hyperplasia 1 (2%)
Duct, Cyst 4 (7%) 1 (25%) 4 (7%)
Duct, Hyperplasia, Atypical 1 (2%)
Skin (60) (50) (60)
Acanthosis 5 (8%) 2 (4%) 1 (2%)
Fibrosis 1 (2%)
Granuloma 1 (2%)
Hyperkeratosis 1 (2%)
Infiltration Cellular, Mast Cell 1 (2%)
Inflammation, Acute 1 (2%)
Inflammation, Acute, Chronic 1 (2%)
Inflammation, Chronic 3 (5%) 3 (6%) 2 (3%)
Parasite External 3 (5%) 3 (5%)
Ulcer, Acute 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (1) (60)
Periosteum, Inflammation, Granulomatous 1 (2%)
Skeletal Muscle (3) (2) (2)
Edema 1 (50%)
Fibrosis 1 (50%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (1) (60)
Compression 1 (2%)
Hemorrhage 1 (2%) 1 (2%)
Mineralization 29 (48%) 1 (100%) 24 (40%)
Necrosis, Focal 1 (2%)
Pigmentation, Cholesterol 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05705-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 09/18/94
Route: GAVAGE Time: 19:48:25
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 50 MG/KG 100MG/KG
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (14) (60)
Congestion 1 (2%) 1 (7%) 2 (3%)
Hemorrhage 3 (5%) 2 (3%)
Inflammation, Acute, Focal 2 (3%)
Inflammation, Chronic 1 (7%) 1 (2%)
Alveolar Epithelium, Hyperplasia, Focal 2 (3%) 2 (14%)
Alveolus, Crystals 1 (2%)
Alveolus, Infiltration Cellular, Histiocyte 1 (7%) 2 (3%)
Artery, Mineralization 1 (2%)
Artery, Media, Hypertrophy 6 (10%) 9 (15%)
Bronchus, Fibrosis 1 (2%)
Interstitium, Fibrosis, Multifocal 1 (2%)
Interstitium, Inflammation, Chronic, Focal 1 (2%)
Perivascular, Infiltration Cellular,
Lymphocyte 8 (13%) 2 (14%) 22 (37%)
Pleura, Inflammation, Acute, Focal 1 (2%)
Nose (60) (60) (60)
Concretion 1 (2%)
Congestion 2 (3%)
Cyst 1 (2%)
Exudate 9 (15%) 15 (25%) 11 (18%)
Granuloma 1 (2%) 1 (2%)
Inflammation, Acute 5 (8%) 15 (25%) 31 (52%)
Inflammation, Chronic 1 (2%)
Inflammation, Chronic Active 2 (3%) 3 (5%) 5 (8%)
Mucosa, Nasopharyngeal Duct, Hyperplasia 1 (2%)
Mucosa, Nasolacrimal Duct, Hyperplasia 32 (53%) 32 (53%) 39 (65%)
Nasolacrimal Duct, Hyperplasia 1 (2%)
Nasolacrimal Duct, Inflammation, Acute 1 (2%)
Olfactory Epithelium, Metaplasia 2 (3%) 5 (8%) 17 (28%)
Trachea (60) (60)
Inflammation, Acute 3 (5%)
Metaplasia, Squamous 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (1)
Cornea, Inflammation, Chronic 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05705-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 09/18/94
Route: GAVAGE Time: 19:48:25
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 50 MG/KG 100MG/KG
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (5) (60)
Cyst 1 (2%)
Hydronephrosis 1 (2%)
Inflammation, Chronic 17 (28%) 21 (35%)
Mineralization 1 (2%)
Nephropathy 11 (18%) 12 (20%)
Renal Tubule, Epithelium, Pigmentation 1 (2%)
Urinary Bladder (57) (1) (56)
Inflammation, Chronic 4 (7%) 3 (5%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05705-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 09/18/94
Route: GAVAGE Time: 19:48:25
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 50 MG/KG 100MG/KG
MALE MALE MALE
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60
Early Deaths
Dead 7 11 26
Moribund 5 10 8
Dosing Accident 2 5
Survivors
Terminal Sacrifice 46 39 21
Animals Examined Microscopically 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (59) (60) (60)
Ulcer, Acute 1 (2%)
Gallbladder (51) (52) (39)
Cyst 1 (2%)
Inflammation, Chronic 1 (2%)
Intestine Large, Cecum (55) (55) (44)
Diverticulum 1 (2%)
Parasite Metazoan 2 (5%)
Intestine Large, Colon (59) (58) (56)
Infiltration Cellular, Plasma Cell 1 (2%)
Inflammation, Chronic Active 1 (2%)
Parasite Metazoan 5 (8%) 4 (7%) 9 (16%)
Intestine Large, Rectum (58) (58) (50)
Inflammation, Acute 1 (2%)
Parasite Metazoan 1 (2%)
Intestine Small, Ileum (54) (54) (37)
Amyloid Deposition 1 (2%)
Parasite Metazoan 1 (2%)
Intestine Small, Jejunum (53) (56) (40)
Hyperplasia, Lymphoid 1 (2%)
Liver (60) (59) (59)
Basophilic Focus 1 (2%)
Basophilic Focus, Multiple 1 (2%)
Clear Cell Focus 1 (2%)
Congestion 1 (2%) 1 (2%)
Cytoplasmic Alteration 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Infarct 2 (3%)
Inflammation, Acute 1 (2%) 2 (3%)
Inflammation, Chronic 3 (5%) 4 (7%) 2 (3%)
Inflammation, Chronic Active, Multifocal 1 (2%)
Necrosis 2 (3%) 4 (7%) 5 (8%)
Bile Duct, Cyst 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05705-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 09/18/94
Route: GAVAGE Time: 19:48:25
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 50 MG/KG 100MG/KG
MALE MALE MALE
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Centrilobular, Fatty Change 1 (2%)
Hepatocyte, Cytomegaly, Diffuse 1 (2%)
Hepatocyte, Necrosis 1 (2%)
Mesentery (4) (1)
Inflammation, Chronic 2 (50%)
Artery, Perivascular, Inflammation, Chronic 1 (100%)
Pancreas (58) (59) (57)
Atrophy 3 (5%) 1 (2%) 4 (7%)
Cyst 1 (2%)
Hyperplasia, Focal 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%)
Necrosis, Multifocal 1 (2%)
Duct, Cyst 1 (2%)
Salivary Glands (60) (57) (60)
Atrophy 2 (4%)
Stomach, Forestomach (60) (60) (59)
Cyst 1 (2%) 1 (2%)
Diverticulum 3 (5%)
Erosion 1 (2%)
Hyperkeratosis 1 (2%)
Hyperplasia, Focal, Squamous 5 (8%) 2 (3%) 8 (14%)
Hyperplasia, Multifocal, Squamous 5 (8%)
Inflammation, Acute 1 (2%)
Inflammation, Acute, Multifocal 1 (2%)
Inflammation, Chronic Active 1 (2%)
Ulcer 2 (3%) 1 (2%)
Stomach, Glandular (58) (59) (54)
Cyst 3 (5%) 1 (2%)
Erosion 1 (2%) 3 (5%) 8 (15%)
Inflammation, Acute 1 (2%) 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%)
Epithelium, Hyperplasia, Focal 1 (2%)
Tooth (5) (2) (2)
Developmental Malformation 1 (50%)
Peridontal Tissue, Inflammation, Acute 1 (20%) 1 (50%)
Peridontal Tissue, Inflammation, Chronic 1 (50%)
Pulp, Inflammation, Acute 3 (60%) 1 (50%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (59) (60)
Abscess, Chronic Active 1 (2%)
Degeneration 21 (35%) 16 (27%) 19 (32%)
Inflammation, Acute, Multifocal 1 (2%)
Inflammation, Chronic 3 (5%)
Mineralization 1 (2%) 3 (5%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05705-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 09/18/94
Route: GAVAGE Time: 19:48:25
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 50 MG/KG 100MG/KG
MALE MALE MALE
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - CONT
Atrium, Pigmentation 1 (2%)
Atrium, Thrombosis 1 (2%) 1 (2%)
Epicardium, Fibrosis 1 (2%)
Epicardium, Inflammation, Chronic 1 (2%)
Valve, Pigmentation 8 (13%) 10 (17%)
Ventricle, Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (60) (59) (60)
Basophilic Focus 1 (2%)
Cyst 1 (2%)
Cytoplasmic Alteration, Focal 1 (2%) 1 (2%)
Hyperplasia 4 (7%) 1 (2%) 3 (5%)
Hyperplasia, Focal 1 (2%)
Hypertrophy, Focal 1 (2%) 1 (2%)
Subcapsular, Hyperplasia 54 (90%) 48 (81%) 49 (82%)
Adrenal Gland, Medulla (59) (59) (60)
Fibrosis 2 (3%)
Hyperplasia 1 (2%)
Hyperplasia, Focal 1 (2%)
Islets, Pancreatic (56) (59) (58)
Hyperplasia 1 (2%)
Parathyroid Gland (41) (19) (35)
Cyst 1 (2%) 2 (11%) 1 (3%)
Pituitary Gland (56) (57) (56)
Congestion 1 (2%)
Cyst 2 (4%) 2 (4%)
Hyperplasia, Focal 1 (2%)
Thyroid Gland (60) (58) (57)
Inflammation, Chronic 2 (3%)
Mineralization 1 (2%)
Follicle, Cyst 6 (10%) 3 (5%) 2 (4%)
Follicular Cell, Hyperplasia 1 (2%) 2 (3%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05705-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 09/18/94
Route: GAVAGE Time: 19:48:25
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 50 MG/KG 100MG/KG
MALE MALE MALE
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Coagulating Gland (1)
Cyst 1 (100%)
Epididymis (60) (60) (60)
Dilatation 1 (2%)
Inflammation, Chronic 1 (2%)
Preputial Gland (8) (6) (8)
Abscess 2 (25%)
Fibrosis 1 (13%)
Hemorrhage 1 (17%)
Inflammation, Acute 1 (13%)
Inflammation, Chronic 1 (13%) 2 (33%) 1 (13%)
Inflammation, Granulomatous 3 (38%)
Duct, Cyst 5 (63%) 4 (67%) 4 (50%)
Prostate (59) (59) (57)
Fibrosis 1 (2%)
Fibrosis, Focal 1 (2%)
Inflammation, Acute 1 (2%) 2 (4%)
Inflammation, Chronic 1 (2%)
Seminal Vesicle (5) (2) (5)
Dilatation 1 (20%) 1 (50%) 1 (20%)
Testes (60) (60) (60)
Degeneration 3 (5%) 4 (7%) 4 (7%)
Infiltration Cellular, Focal, Lymphocyte 1 (2%)
Mineralization 2 (3%) 8 (13%) 2 (3%)
Unilateral, Atrophy 2 (3%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (60) (60)
Myeloid Cell, Hyperplasia 3 (5%) 4 (7%)
Lymph Node (58) (55) (51)
Iliac, Hyperplasia, Plasma Cell 1 (2%)
Inguinal, Hyperplasia, Lymphoid 2 (3%)
Inguinal, Hyperplasia, Plasma Cell 4 (7%) 2 (4%) 1 (2%)
Inguinal, Inflammation, Acute 1 (2%)
Inguinal, Pigmentation 2 (3%) 9 (16%)
Mediastinal, Hemorrhage 1 (2%)
Pancreatic, Hyperplasia, Lymphoid 1 (2%)
Lymph Node, Mesenteric (56) (55) (50)
Congestion, Focal 1 (2%)
Hematopoietic Cell Proliferation Granulocytic 1 (2%)
Hematopoietic Cell Proliferation Erythrocytic 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 2 (4%)
Hyperplasia, Plasma Cell 1 (2%)
Infiltration Cellular, Histiocyte 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05705-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 09/18/94
Route: GAVAGE Time: 19:48:25
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 50 MG/KG 100MG/KG
MALE MALE MALE
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Inflammation, Acute 1 (2%) 2 (4%)
Pigmentation, Hemosiderin 1 (2%)
Spleen (59) (58) (60)
Atrophy, Focal 1 (2%)
Cyst 1 (2%)
Hematopoietic Cell Proliferation Granulocytic 4 (7%) 3 (5%)
Hematopoietic Cell Proliferation Erythrocytic 1 (2%) 1 (2%) 6 (10%)
Hyperplasia, Lymphoid 1 (2%) 2 (3%) 5 (8%)
Hyperplasia, Plasma Cell 1 (2%) 3 (5%)
Infarct 1 (2%)
Infiltration Cellular, Histiocyte 1 (2%)
Pigmentation, Hemosiderin 2 (3%)
Capsule, Fibrosis 1 (2%) 1 (2%)
Thymus (49) (42) (38)
Atrophy 4 (8%) 1 (2%) 1 (3%)
Cyst 4 (8%) 3 (7%) 4 (11%)
Ectopic Parathyroid Gland 1 (2%) 3 (7%)
Necrosis 1 (2%) 1 (3%)
Epithelial Cell, Hyperplasia 9 (18%) 7 (17%) 8 (21%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (13) (9) (3)
Hemorrhage, Focal 1 (8%)
Skin (60) (60) (59)
Abscess 1 (2%)
Acanthosis 1 (2%) 2 (3%)
Fibrosis 1 (2%) 2 (3%) 2 (3%)
Hyperkeratosis 1 (2%)
Hyperplasia, Basal Cell, Focal 1 (2%)
Inflammation, Acute 1 (2%) 2 (3%)
Inflammation, Chronic 1 (2%) 2 (3%)
Parasite External 2 (3%) 3 (5%) 7 (12%)
Ulcer 1 (2%) 4 (7%)
Epithelium, Atrophy 1 (2%)
Hair Follicle, Atrophy 2 (3%)
Prepuce, Abscess 1 (2%)
Prepuce, Inflammation, Acute 1 (2%) 2 (3%)
Prepuce, Ulcer 3 (5%)
Scrotal, Ulcer, Acute 1 (2%)
Subcutaneous Tissue, Inflammation, Chronic 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 05705-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 09/18/94
Route: GAVAGE Time: 19:48:25
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 50 MG/KG 100MG/KG
MALE MALE MALE
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (60) (60)
Fracture Healed 1 (2%) 1 (2%)
Osteoporosis, Focal 1 (2%)
Skeletal Muscle (1) (1) (1)
Inflammation, Chronic 1 (100%)
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NERVOUS SYSTEM
Brain (60) (58) (60)
Congestion 1 (2%)
Inflammation, Acute, Multifocal 1 (2%)
Melanosis 1 (2%)
Mineralization 45 (75%) 34 (59%) 28 (47%)
Necrosis, Focal 1 (2%)
Meninges, Perivascular, Inflammation, Chronic 1 (2%)
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RESPIRATORY SYSTEM
Lung (60) (59) (60)
Congestion 1 (2%) 2 (3%) 11 (18%)
Hemorrhage 1 (2%) 2 (3%)
Alveolar Epithelium, Hyperplasia, Focal 1 (2%) 4 (7%) 2 (3%)
Alveolus, Infiltration Cellular, Histiocyte 2 (3%) 3 (5%) 3 (5%)
Interstitium, Inflammation, Chronic 2 (3%) 2 (3%)
Perivascular, Infiltration Cellular,
Lymphocyte 5 (8%) 6 (10%) 2 (3%)
Pleura, Fibrosis 1 (2%)
Nose (60) (59) (60)
Exudate 15 (25%) 18 (31%) 22 (37%)
Granuloma 2 (3%) 1 (2%)
Inflammation, Acute 3 (5%) 7 (12%) 24 (40%)
Inflammation, Chronic 2 (3%) 2 (3%)
Inflammation, Chronic Active 2 (3%)
Mucosa, Turbinate, Hyperplasia 1 (2%)
Mucosa, Nasolacrimal Duct, Hyperplasia 23 (38%) 28 (47%) 24 (40%)
Nasolacrimal Duct, Inflammation, Acute 1 (2%) 2 (3%) 3 (5%)
Nasolacrimal Duct, Inflammation, Chronic
Active 1 (2%)
Olfactory Epithelium, Metaplasia 3 (5%) 2 (3%)
Submucosa, Cyst 1 (2%)
Turbinate, Atrophy 1 (2%)
Turbinate, Inflammation, Chronic, Multifocal 1 (2%)
Vomeronasal Organ, Cyst 1 (2%)
Trachea (60) (59) (60)
a Number of animals examined microscopically at site and number of animals with lesion
Page 14
NTP Experiment-Test: 05705-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 09/18/94
Route: GAVAGE Time: 19:48:25
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 50 MG/KG 100MG/KG
MALE MALE MALE
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Inflammation, Acute 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Chronic Active 1 (2%)
Metaplasia, Squamous 1 (2%)
Ulcer, Acute 1 (2%)
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SPECIAL SENSES SYSTEM
Eye (3)
Inflammation, Acute 1 (33%)
Neovascularization 2 (67%)
Cornea, Necrosis 1 (33%)
Harderian Gland (3) (3) (2)
Cyst, Multiple 1 (33%)
Inflammation, Chronic 1 (33%)
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URINARY SYSTEM
Kidney (60) (59) (60)
Cyst 3 (5%) 4 (7%) 5 (8%)
Inflammation, Acute 1 (2%) 2 (3%)
Mineralization 2 (3%) 2 (3%) 2 (3%)
Nephropathy 36 (60%) 38 (64%) 28 (47%)
Capsule, Fibrosis 1 (2%)
Pelvis, Inflammation, Chronic 2 (3%)
Renal Tubule, Hyperplasia, Focal 1 (2%)
Renal Tubule, Necrosis, Acute 6 (10%)
Urinary Bladder (57) (58) (54)
Calculus Gross Observation 1 (2%)
Diverticulum 1 (2%)
Ectopic Tissue 1 (2%)
Inflammation, Acute 1 (2%) 2 (4%)
Inflammation, Chronic 1 (2%)
Transitional Epithelium, Hyperplasia, Focal 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
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