TR 396 Rat Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
MONOCHLOROACETIC ACID
NTP Experiment-Test: 05705-02 Report: PEIRPT03
Study Type: CHRONIC Date: 09/18/94
Route: GAVAGE Time: 21:14:39
Facility: International Research and Development Corp.
Chemical CAS #: 79-11-8
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05705-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 09/18/94
Route: GAVAGE Time: 21:14:39
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 15 MG/KG 30 MG/KG
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 70 70 70
Scheduled Sacrifice 17 17 17
Early Deaths
Moribund 14 21 13
Dead 2 11 13
Dosing Accident 2 1
Survivors
Terminal Sacrifice 37 19 25
Moribund 1
Animals Examined Microscopically 53 53 53
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (53) (52) (52)
Inflammation, Acute, Focal 1 (2%)
Intestine Large, Cecum (53) (53) (51)
Autolysis 3 (6%)
Parasite Metazoan 1 (2%)
Intestine Large, Colon (53) (53) (51)
Autolysis 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Parasite Metazoan 8 (15%) 3 (6%) 6 (12%)
Intestine Large, Rectum (52) (53) (50)
Hyperplasia, Lymphoid 1 (2%)
Parasite Metazoan 2 (4%) 1 (2%) 3 (6%)
Submucosa, Inflammation, Acute, Focal 1 (2%)
Intestine Small, Duodenum (53) (51) (51)
Autolysis 1 (2%)
Intestine Small, Ileum (53) (53) (48)
Autolysis 3 (6%)
Congestion 2 (4%)
Edema 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 2 (4%)
Parasite Metazoan 1 (2%)
Intestine Small, Jejunum (53) (52) (49)
Autolysis 3 (6%)
Liver (53) (53) (53)
Angiectasis 1 (2%)
Angiectasis, Focal 1 (2%) 1 (2%)
Basophilic Focus 16 (30%) 6 (11%) 16 (30%)
Basophilic Focus, Multiple 21 (40%) 17 (32%) 14 (26%)
Congestion 1 (2%) 2 (4%) 1 (2%)
Cytoplasmic Alteration, Focal 6 (11%) 3 (6%) 4 (8%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05705-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 09/18/94
Route: GAVAGE Time: 21:14:39
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 15 MG/KG 30 MG/KG
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Degeneration, Fatty 1 (2%) 1 (2%)
Hemorrhage, Focal 1 (2%)
Hepatodiaphragmatic Nodule 4 (8%) 1 (2%) 3 (6%)
Inflammation, Acute, Focal 2 (4%) 2 (4%)
Inflammation, Granulomatous, Multifocal 21 (40%) 19 (36%) 18 (34%)
Necrosis, Acute, Coagulative, Multifocal 1 (2%)
Necrosis, Acute, Focal 2 (4%) 1 (2%)
Vacuolization Cytoplasmic, Focal 1 (2%) 1 (2%)
Bile Duct, Hyperplasia 7 (13%) 1 (2%) 3 (6%)
Hepatocyte, Hypertrophy, Focal 1 (2%)
Mesentery (4) (2)
Inflammation, Chronic, Multifocal 1 (25%) 1 (50%)
Fat, Necrosis, Focal 3 (75%) 2 (100%)
Pancreas (53) (53) (51)
Atrophy, Focal 19 (36%) 15 (28%) 10 (20%)
Cytoplasmic Alteration, Focal 1 (2%)
Inflammation, Chronic, Focal 1 (2%)
Acinus, Hyperplasia 1 (2%)
Salivary Glands (53) (53) (53)
Atrophy, Focal 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia, Focal 1 (2%)
Infiltration Cellular, Multifocal, Lymphocyte 2 (4%)
Inflammation, Chronic 1 (2%)
Duct, Inflammation, Chronic 5 (9%) 2 (4%)
Duct, Inflammation, Chronic Active 8 (15%) 7 (13%)
Stomach, Forestomach (51) (52) (53)
Inflammation, Acute 2 (4%) 3 (6%) 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%)
Inflammation, Chronic Active 2 (4%) 1 (2%)
Ulcer 1 (2%)
Epithelium, Hyperplasia 6 (12%) 4 (8%) 4 (8%)
Muscularis, Hypertrophy, Focal 1 (2%)
Submucosa, Inflammation, Acute 1 (2%)
Stomach, Glandular (53) (53) (53)
Infiltration Cellular, Focal, Lymphocyte 1 (2%)
Inflammation, Acute 1 (2%) 1 (2%)
Inflammation, Chronic Active 1 (2%)
Necrosis, Acute 1 (2%) 4 (8%) 3 (6%)
Pigmentation, Focal 1 (2%)
Arteriole, Submucosa, Thrombosis 1 (2%)
Serosa, Inflammation, Chronic, Multifocal 1 (2%)
Submucosa, Inflammation, Chronic 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05705-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 09/18/94
Route: GAVAGE Time: 21:14:39
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 15 MG/KG 30 MG/KG
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (53) (53) (53)
Inflammation, Chronic 41 (77%) 31 (58%) 36 (68%)
Atrium Left, Thrombosis 1 (2%) 2 (4%)
Coronary Artery, Inflammation, Chronic 1 (2%)
Pericardium, Fibrosis, Focal 1 (2%)
Valve, Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (53) (53) (52)
Angiectasis, Focal 1 (2%)
Congestion 1 (2%) 1 (2%) 2 (4%)
Ectasia 2 (4%)
Hemorrhage 2 (4%) 1 (2%)
Hyperplasia, Focal 10 (19%) 8 (15%) 12 (23%)
Hypertrophy 1 (2%)
Hypertrophy, Focal 9 (17%) 4 (8%) 4 (8%)
Mineralization 1 (2%)
Necrosis, Acute, Focal 1 (2%)
Thrombosis 1 (2%)
Vacuolization Cytoplasmic, Diffuse 2 (4%)
Vacuolization Cytoplasmic, Focal 11 (21%) 9 (17%) 6 (12%)
Bilateral, Hyperplasia, Focal 1 (2%)
Adrenal Gland, Medulla (52) (52) (53)
Hyperplasia, Focal 4 (8%) 4 (8%)
Islets, Pancreatic (53) (53) (51)
Hyperplasia 1 (2%)
Parathyroid Gland (43) (43) (42)
Congestion, Focal 1 (2%)
Hyperplasia 1 (2%)
Pituitary Gland (53) (53) (53)
Autolysis 1 (2%)
Congestion, Focal 1 (2%)
Hemorrhage 2 (4%)
Pigmentation, Focal 1 (2%)
Pars Distalis, Angiectasis 6 (11%) 4 (8%) 5 (9%)
Pars Distalis, Cyst 10 (19%) 4 (8%) 7 (13%)
Pars Distalis, Ectasia 1 (2%)
Pars Distalis, Hyperplasia 9 (17%) 12 (23%) 13 (25%)
Pars Distalis, Vacuolization Nuclear 1 (2%)
Thyroid Gland (53) (52) (52)
Ultimobranchial Cyst 1 (2%) 1 (2%)
C-Cell, Hyperplasia 20 (38%) 8 (15%) 16 (31%)
Follicle, Cyst 1 (2%)
Follicular Cell, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05705-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 09/18/94
Route: GAVAGE Time: 21:14:39
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 15 MG/KG 30 MG/KG
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (44) (45) (48)
Hyperplasia 1 (2%) 1 (2%)
Hyperplasia, Squamous 1 (2%)
Inflammation, Acute 5 (11%) 8 (18%) 4 (8%)
Inflammation, Chronic 11 (25%) 6 (13%) 12 (25%)
Inflammation, Chronic Active 6 (14%) 1 (2%) 5 (10%)
Ovary (53) (53) (53)
Atrophy 1 (2%)
Hemorrhage 1 (2%)
Follicle, Cyst 6 (11%) 2 (4%) 5 (9%)
Periovarian Tissue, Cyst 1 (2%) 1 (2%)
Uterus (53) (53) (53)
Dilatation 2 (4%) 5 (9%) 3 (6%)
Hemorrhage 1 (2%)
Inflammation, Acute 2 (4%)
Inflammation, Chronic 1 (2%)
Endometrium, Fibrosis 1 (2%)
Endometrium, Hyperplasia, Cystic 1 (2%) 2 (4%)
Vagina (1)
Inflammation, Acute 1 (100%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (53) (53) (53)
Hyperplasia 1 (2%) 1 (2%)
Hypoplasia 1 (2%)
Myelofibrosis 2 (4%) 3 (6%)
Pigmentation 1 (2%)
Myeloid Cell, Hyperplasia 4 (8%)
Lymph Node (53) (52) (53)
Mediastinal, Congestion 2 (4%)
Renal, Congestion 1 (2%)
Renal, Hemorrhage 1 (2%)
Lymph Node, Mesenteric (52) (52) (53)
Congestion 1 (2%)
Edema 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Lymphocyte, Depletion Cellular 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05705-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 09/18/94
Route: GAVAGE Time: 21:14:39
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 15 MG/KG 30 MG/KG
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Spleen (53) (53) (53)
Angiectasis 1 (2%)
Fibrosis 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation Granulocytic 2 (4%) 5 (9%)
Inflammation, Focal, Granulomatous 1 (2%)
Necrosis, Focal 1 (2%)
Pigmentation 3 (6%) 1 (2%) 4 (8%)
Capsule, Fibrosis, Multifocal 1 (2%)
Thymus (51) (51) (44)
Autolysis 1 (2%)
Cyst 2 (4%) 1 (2%)
Hemorrhage 1 (2%) 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Medulla, Hyperplasia, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (53) (53) (51)
Galactocele 5 (9%) 5 (10%)
Hyperplasia 23 (43%) 22 (43%)
Hyperplasia, Cystic 1 (2%)
Inflammation, Acute 1 (2%) 1 (2%)
Inflammation, Chronic Active, Multifocal 1 (2%)
Duct, Ectasia 23 (43%) 11 (21%) 2 (4%)
Skin (53) (52) (52)
Face, Inflammation, Acute 1 (2%)
Face, Inflammation, Chronic Active, Focal 1 (2%)
Subcutaneous Tissue, Hemorrhage 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (53) (53) (53)
Hyperostosis 1 (2%)
Osteopetrosis 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (53) (53) (53)
Congestion 2 (4%)
Hemorrhage, Focal 1 (2%)
Hydrocephalus 1 (2%)
Inflammation, Acute, Focal 1 (2%)
Inflammation, Chronic, Focal 1 (2%)
Cerebellum, Cyst 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05705-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 09/18/94
Route: GAVAGE Time: 21:14:39
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 15 MG/KG 30 MG/KG
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - CONT
Third Ventricle, Dilatation 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (53) (53) (53)
Congestion 1 (2%) 6 (11%) 13 (25%)
Fibrosis, Focal 1 (2%)
Hemorrhage 1 (2%) 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%) 3 (6%)
Inflammation, Granulomatous, Multifocal 1 (2%)
Alveolar Epithelium, Hyperplasia, Focal 1 (2%) 2 (4%)
Alveolus, Infiltration Cellular, Histiocyte 3 (6%) 3 (6%) 2 (4%)
Interstitium, Infiltration Cellular,
Multifocal 1 (2%)
Perivascular, Inflammation, Chronic 14 (26%) 12 (23%)
Nose (52) (53) (48)
Autolysis 4 (8%)
Foreign Body 1 (2%) 1 (2%)
Fungus 5 (10%) 1 (2%) 1 (2%)
Hemorrhage 3 (6%)
Inflammation, Chronic, Focal 1 (2%)
Mucosa, Inflammation, Acute 6 (11%) 5 (10%)
Mucosa, Inflammation, Chronic Active 5 (10%) 2 (4%) 1 (2%)
Nasolacrimal Duct, Cyst 1 (2%) 1 (2%)
Nasolacrimal Duct, Inflammation, Acute 4 (8%) 1 (2%) 6 (13%)
Nasolacrimal Duct, Inflammation, Chronic 4 (8%)
Nasolacrimal Duct, Inflammation, Chronic
Active 1 (2%) 1 (2%) 3 (6%)
Sinus, Inflammation, Acute 1 (2%) 1 (2%)
Vein, Thrombosis 1 (2%)
Trachea (53) (53) (53)
Inflammation, Chronic 2 (4%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (3) (4) (2)
Bilateral, Lens, Cataract 1 (25%)
Lens, Cataract 2 (67%) 2 (50%) 2 (100%)
Retina, Degeneration 3 (100%) 1 (25%) 2 (100%)
Sclera, Mineralization, Focal 1 (50%)
Harderian Gland (1)
Inflammation, Chronic 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05705-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 09/18/94
Route: GAVAGE Time: 21:14:39
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 15 MG/KG 30 MG/KG
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (53) (53) (52)
Autolysis 7 (13%) 1 (2%)
Congestion 3 (6%) 1 (2%)
Hemorrhage 1 (2%) 1 (2%)
Inflammation, Multifocal, Suppurative 1 (2%)
Mineralization, Focal 2 (4%)
Mineralization, Multifocal 9 (17%) 2 (4%) 15 (29%)
Nephropathy 46 (87%) 38 (72%) 35 (67%)
Cortex, Renal Tubule, Necrosis 1 (2%)
Cortex, Renal Tubule, Necrosis, Focal 1 (2%)
Renal Tubule, Epithelium, Pigmentation 3 (6%) 4 (8%) 2 (4%)
Urinary Bladder (52) (52) (49)
Calculus Micro Observation Only, Multifocal 1 (2%)
Hemorrhage, Focal 1 (2%)
Hyperplasia, Papillary 1 (2%)
Infiltration Cellular, Lymphocyte 1 (2%)
Transitional Epithelium, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05705-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 09/18/94
Route: GAVAGE Time: 21:14:39
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 15 MG/KG 30 MG/KG
MALE MALE MALE
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 70 70 70
Scheduled Sacrifice 17 17 17
Early Deaths
Dead 8 11 20
Moribund 17 21 15
Accident 1
Dosing Accident 2
Survivors
Terminal Sacrifice 27 21 16
Animals Examined Microscopically 53 53 53
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (53) (53) (53)
Wall, Inflammation, Chronic 1 (2%)
Intestine Large, Cecum (52) (52) (53)
Autolysis 1 (2%)
Inflammation, Acute 2 (4%) 1 (2%) 1 (2%)
Parasite Metazoan 1 (2%)
Intestine Large, Colon (53) (53) (53)
Hyperplasia, Lymphoid 1 (2%)
Infiltration Cellular, Lymphocyte 1 (2%)
Parasite Metazoan 11 (21%) 6 (11%) 12 (23%)
Intestine Large, Rectum (53) (52) (52)
Inflammation, Acute 1 (2%)
Parasite Metazoan 5 (9%) 2 (4%)
Intestine Small (53) (53) (53)
Perivascular, Inflammation, Chronic 1 (2%)
Serosa, Inflammation, Chronic 1 (2%)
Intestine Small, Duodenum (52) (53) (53)
Autolysis 1 (2%)
Inflammation, Chronic 1 (2%)
Necrosis, Acute, Focal 1 (2%)
Intestine Small, Ileum (53) (52) (51)
Autolysis 1 (2%) 3 (6%) 1 (2%)
Parasite Metazoan 1 (2%)
Intestine Small, Jejunum (51) (52) (52)
Autolysis 1 (2%) 2 (4%)
Liver (53) (53) (53)
Angiectasis 1 (2%)
Angiectasis, Focal 1 (2%) 1 (2%)
Basophilic Focus 9 (17%) 1 (2%) 5 (9%)
Basophilic Focus, Multiple 3 (6%) 10 (19%) 3 (6%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05705-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 09/18/94
Route: GAVAGE Time: 21:14:39
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 15 MG/KG 30 MG/KG
MALE MALE MALE
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Clear Cell Focus 1 (2%) 1 (2%)
Congestion 1 (2%) 2 (4%) 1 (2%)
Cytoplasmic Alteration, Focal 9 (17%) 3 (6%) 4 (8%)
Cytoplasmic Alteration, Multifocal 2 (4%)
Fatty Change, Diffuse 1 (2%)
Fatty Change, Multifocal 1 (2%)
Hepatodiaphragmatic Nodule 2 (4%)
Hyperplasia, Focal 1 (2%)
Inflammation, Acute, Multifocal 1 (2%)
Inflammation, Chronic 3 (6%)
Inflammation, Granulomatous, Multifocal 1 (2%) 3 (6%)
Necrosis, Acute, Focal 2 (4%) 1 (2%) 3 (6%)
Pigmentation, Diffuse 1 (2%)
Thrombosis 1 (2%) 1 (2%)
Vacuolization Cytoplasmic, Focal 1 (2%) 1 (2%) 2 (4%)
Artery, Thrombosis 1 (2%)
Bile Duct, Hyperplasia 20 (38%) 11 (21%) 17 (32%)
Centrilobular, Fatty Change 1 (2%) 1 (2%)
Centrilobular, Vacuolization Cytoplasmic 1 (2%)
Hepatocyte, Degeneration, Cystic, Focal 5 (9%) 3 (6%) 2 (4%)
Hepatocyte, Hypertrophy, Focal 1 (2%)
Mesentery (2) (1) (2)
Inflammation, Chronic 1 (50%)
Fat, Necrosis, Chronic, Multifocal 1 (50%)
Fat, Necrosis, Focal 1 (100%)
Pancreas (52) (53) (52)
Atrophy, Focal 16 (31%) 20 (38%) 14 (27%)
Congestion, Focal 1 (2%)
Cytoplasmic Alteration, Focal 1 (2%)
Hyperplasia, Focal 1 (2%)
Infiltration Cellular, Focal, Lymphocyte 1 (2%)
Inflammation, Chronic 1 (2%)
Artery, Inflammation, Chronic 1 (2%)
Artery, Mineralization 1 (2%)
Duct, Ectasia, Focal 1 (2%) 1 (2%)
Perivascular, Inflammation, Chronic 2 (4%)
Salivary Glands (52) (53) (53)
Atrophy, Diffuse 1 (2%)
Inflammation, Acute, Focal 3 (6%)
Inflammation, Chronic 1 (2%) 2 (4%)
Duct, Ectasia, Focal 1 (2%)
Duct, Inflammation, Acute 1 (2%)
Duct, Inflammation, Chronic Active 1 (2%)
Periductular, Inflammation, Chronic 1 (2%)
Stomach (53) (52) (53)
Perivascular, Inflammation, Chronic 1 (2%)
Serosa, Inflammation, Chronic 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05705-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 09/18/94
Route: GAVAGE Time: 21:14:39
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 15 MG/KG 30 MG/KG
MALE MALE MALE
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Stomach, Forestomach (53) (52) (53)
Hyperplasia 1 (2%)
Inflammation, Acute 3 (6%) 4 (8%) 3 (6%)
Inflammation, Chronic 2 (4%) 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Mineralization 1 (2%) 2 (4%)
Necrosis, Focal 1 (2%)
Epithelium, Hyperplasia 2 (4%) 6 (12%) 2 (4%)
Serosa, Inflammation, Chronic 1 (2%)
Stomach, Glandular (52) (52) (53)
Hemorrhage, Focal 1 (2%)
Infiltration Cellular, Focal, Lymphocyte 4 (8%)
Infiltration Cellular, Lymphocyte 4 (8%)
Inflammation, Acute 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%) 2 (4%) 1 (2%)
Inflammation, Chronic Active 1 (2%)
Mineralization 1 (2%) 4 (8%) 3 (6%)
Necrosis, Focal 2 (4%) 5 (10%) 2 (4%)
Tongue (3)
Epithelium, Hyperplasia, Focal 2 (67%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (53) (53) (52)
Inflammation, Acute 1 (2%)
Aorta, Mineralization 1 (2%) 2 (4%)
Heart (52) (53) (53)
Fibrosis, Focal 2 (4%)
Inflammation, Chronic 48 (92%) 45 (85%) 46 (87%)
Mineralization 2 (4%) 3 (6%) 2 (4%)
Artery, Mineralization, Multifocal 1 (2%)
Atrium Left, Thrombosis 5 (10%) 4 (8%) 3 (6%)
Perivascular, Inflammation, Chronic 1 (2%)
Valve, Thrombosis 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (52) (51) (53)
Cyst 1 (2%)
Hemorrhage, Focal 1 (2%)
Hyperplasia 1 (2%)
Hyperplasia, Focal 9 (17%) 8 (16%) 12 (23%)
Hypertrophy, Focal 5 (10%) 5 (10%) 3 (6%)
Necrosis, Focal 1 (2%) 2 (4%)
Vacuolization Cytoplasmic, Diffuse 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05705-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 09/18/94
Route: GAVAGE Time: 21:14:39
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 15 MG/KG 30 MG/KG
MALE MALE MALE
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Vacuolization Cytoplasmic, Focal 7 (13%) 10 (20%) 5 (9%)
Adrenal Gland, Medulla (51) (50) (53)
Hyperplasia, Focal 10 (20%) 6 (12%) 7 (13%)
Mineralization, Focal 1 (2%)
Thrombosis 1 (2%) 1 (2%)
Bilateral, Hyperplasia, Focal 1 (2%)
Islets, Pancreatic (52) (53) (52)
Hyperplasia, Focal 1 (2%)
Parathyroid Gland (48) (47) (37)
Hyperplasia 3 (6%) 4 (11%)
Hyperplasia, Focal 1 (2%)
Pituitary Gland (53) (52) (53)
Hemorrhage 1 (2%)
Pars Distalis, Angiectasis 1 (2%) 3 (6%) 1 (2%)
Pars Distalis, Cyst 2 (4%) 2 (4%) 1 (2%)
Pars Distalis, Hyperplasia 8 (15%) 7 (13%) 6 (11%)
Pars Intermedia, Hyperplasia, Focal 1 (2%)
Pars Nervosa, Hyperplasia 1 (2%)
Thyroid Gland (53) (53) (53)
Ultimobranchial Cyst 1 (2%)
C-Cell, Hyperplasia 11 (21%) 6 (11%) 4 (8%)
Follicular Cell, Hyperplasia 3 (6%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (52) (50) (52)
Duct, Epithelium, Degeneration 1 (2%)
Penis (1)
Inflammation, Acute 1 (100%)
Preputial Gland (51) (52) (52)
Cyst 1 (2%)
Ectasia 1 (2%)
Hyperplasia 2 (4%)
Inflammation, Acute 10 (20%) 7 (13%) 8 (15%)
Inflammation, Chronic 18 (35%) 28 (54%) 16 (31%)
Inflammation, Chronic Active 1 (2%)
Duct, Hyperplasia, Squamous 1 (2%)
Prostate (48) (52) (53)
Hyperplasia, Focal 4 (8%) 4 (8%) 1 (2%)
Inflammation, Acute 6 (13%) 4 (8%)
Inflammation, Chronic 1 (2%) 5 (10%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05705-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 09/18/94
Route: GAVAGE Time: 21:14:39
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 15 MG/KG 30 MG/KG
MALE MALE MALE
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Inflammation, Chronic Active 2 (4%)
Mineralization 2 (4%)
Epithelium, Degeneration, Focal 1 (2%)
Testes (53) (51) (52)
Atrophy 6 (11%) 6 (12%) 1 (2%)
Hemorrhage 1 (2%)
Infarct, Diffuse 1 (2%)
Mineralization, Focal 1 (2%)
Bilateral, Interstitial Cell, Hyperplasia 1 (2%) 1 (2%)
Interstitial Cell, Hyperplasia 6 (11%) 6 (12%) 6 (12%)
Seminiferous Tubule, Degeneration 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (53) (52) (52)
Hyperplasia 2 (4%) 2 (4%)
Hyperplasia, Megakaryocyte 1 (2%)
Hypoplasia 2 (4%) 2 (4%)
Myelofibrosis 2 (4%) 2 (4%)
Myeloid Cell, Hyperplasia 2 (4%) 3 (6%) 1 (2%)
Lymph Node (53) (52) (53)
Axillary, Congestion 1 (2%)
Axillary, Hyperplasia 1 (2%)
Iliac, Hyperplasia, Plasma Cell 1 (2%)
Iliac, Inflammation, Focal, Granulomatous 1 (2%)
Inguinal, Infiltration Cellular, Plasma Cell 1 (2%)
Inguinal, Inflammation, Acute, Multifocal 1 (2%)
Mediastinal, Congestion 5 (9%) 2 (4%)
Mediastinal, Hemorrhage 1 (2%)
Mediastinal, Hyperplasia 1 (2%) 1 (2%)
Pancreatic, Congestion 1 (2%)
Pancreatic, Fibrosis, Focal 1 (2%)
Pancreatic, Inflammation, Chronic 1 (2%)
Renal, Hemorrhage 1 (2%)
Lymph Node, Mesenteric (53) (52) (53)
Congestion 1 (2%) 1 (2%) 1 (2%)
Hemorrhage 2 (4%)
Hyperplasia 1 (2%) 1 (2%)
Hyperplasia, Re Cell 1 (2%)
Necrosis, Focal 1 (2%)
Spleen (53) (53) (53)
Congestion 2 (4%)
Fibrosis 1 (2%) 5 (9%) 1 (2%)
Fibrosis, Focal 1 (2%)
Hematopoietic Cell Proliferation 2 (4%)
Hematopoietic Cell Proliferation Granulocytic 2 (4%) 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 05705-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 09/18/94
Route: GAVAGE Time: 21:14:39
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 15 MG/KG 30 MG/KG
MALE MALE MALE
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hemorrhage, Multifocal 1 (2%)
Necrosis, Focal 1 (2%)
Pigmentation, Diffuse 1 (2%)
Capsule, Fibrosis, Focal 2 (4%)
Thymus (47) (48) (50)
Congestion 2 (4%)
Cyst, Multiple 1 (2%) 3 (6%)
Ectasia 1 (2%)
Hemorrhage 2 (4%)
Hyperplasia 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (53) (52) (53)
Fibrosis 1 (2%)
Hyperplasia 2 (4%) 6 (12%) 9 (17%)
Hyperplasia, Cystic 1 (2%) 2 (4%)
Mineralization 1 (2%)
Pigmentation 1 (2%) 1 (2%)
Duct, Ectasia 2 (4%) 8 (15%)
Skin (53) (51) (53)
Hemorrhage 1 (2%)
Inflammation, Acute 1 (2%) 1 (2%)
Inflammation, Chronic, Focal 1 (2%)
Inflammation, Chronic Active 1 (2%)
Face, Inflammation, Acute, Focal 1 (2%)
Subcutaneous Tissue, Edema 1 (2%)
Subcutaneous Tissue, Inflammation, Acute 1 (2%)
Subcutaneous Tissue, Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (53) (52) (52)
Fibrous Osteodystrophy 1 (2%) 4 (8%) 3 (6%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (53) (53) (53)
Congestion 1 (2%)
Hemorrhage, Focal 1 (2%) 1 (2%) 1 (2%)
Hydrocephalus 1 (2%)
Cerebellum, Pigmentation, Focal 1 (2%)
Meninges, Vein, Cerebrum, Thrombosis 1 (2%)
Thalamus, Inflammation, Chronic, Focal 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 14
NTP Experiment-Test: 05705-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 09/18/94
Route: GAVAGE Time: 21:14:39
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 15 MG/KG 30 MG/KG
MALE MALE MALE
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (53) (53) (53)
Congestion 2 (4%) 6 (11%) 10 (19%)
Fibrosis, Multifocal 2 (4%)
Hemorrhage, Focal 2 (4%)
Inflammation, Acute, Focal 2 (4%)
Inflammation, Chronic 3 (6%) 4 (8%) 4 (8%)
Inflammation, Focal, Granulomatous 4 (8%)
Mineralization, Focal 1 (2%)
Alveolar Epithelium, Hyperplasia 1 (2%)
Alveolar Epithelium, Hyperplasia, Focal 1 (2%)
Alveolus, Infiltration Cellular, Histiocyte 2 (4%) 4 (8%) 1 (2%)
Alveolus, Pigmentation 1 (2%)
Artery, Media, Hypertrophy 1 (2%)
Bronchiole, Inflammation, Chronic Active,
Multifocal 1 (2%)
Peribronchial, Infiltration Cellular,
Lymphocyte 1 (2%)
Perivascular, Inflammation, Chronic 4 (8%) 2 (4%) 2 (4%)
Pleura, Fibrosis, Focal 1 (2%)
Pleura, Infiltration Cellular, Focal,
Histiocyte 1 (2%)
Subpleura, Inflammation, Chronic 2 (4%)
Nose (52) (53) (53)
Autolysis 2 (4%) 3 (6%)
Congestion 2 (4%)
Cyst 3 (6%)
Foreign Body 3 (6%)
Fungus 8 (15%) 8 (15%) 5 (9%)
Metaplasia, Squamous 6 (11%)
Mucosa, Concretion, Focal 1 (2%)
Mucosa, Inflammation, Acute 7 (13%) 4 (8%) 9 (17%)
Mucosa, Inflammation, Chronic 3 (6%)
Mucosa, Inflammation, Chronic Active 9 (17%) 8 (15%) 15 (28%)
Nasolacrimal Duct, Inflammation, Acute 3 (6%) 1 (2%) 1 (2%)
Nasolacrimal Duct, Inflammation, Chronic 1 (2%) 2 (4%)
Respiratory Epithelium, Hyperplasia 2 (4%)
Respiratory Epithelium, Hyperplasia,
Papillary 1 (2%)
Vomeronasal Organ, Inflammation, Acute 1 (2%)
Trachea (53) (53) (53)
Inflammation, Chronic 2 (4%) 2 (4%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 15
NTP Experiment-Test: 05705-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MONOCHLOROACETIC ACID Date: 09/18/94
Route: GAVAGE Time: 21:14:39
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 15 MG/KG 30 MG/KG
MALE MALE MALE
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (4) (3) (3)
Bilateral, Lens, Cataract 1 (33%) 1 (33%)
Lens, Cataract 2 (50%) 1 (33%) 2 (67%)
Retina, Degeneration 1 (25%) 2 (67%)
Sclera, Mineralization, Focal 3 (75%) 3 (100%) 1 (33%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (53) (53) (53)
Autolysis 6 (11%)
Calculus Micro Observation Only 1 (2%)
Congestion 1 (2%) 1 (2%)
Mineralization, Multifocal 1 (2%)
Nephropathy 53 (100%) 51 (96%) 48 (91%)
Cortex, Cyst 1 (2%) 2 (4%)
Medulla, Inflammation, Multifocal 1 (2%)
Pelvis, Calculus Gross Observation 1 (2%)
Pelvis, Inflammation, Acute 2 (4%) 1 (2%)
Pelvis, Transitional Epithelium, Hyperplasia 2 (4%) 3 (6%) 2 (4%)
Renal Tubule, Epithelium, Pigmentation 3 (6%) 1 (2%) 1 (2%)
Urinary Bladder (51) (52) (53)
Hemorrhage 1 (2%)
Inflammation, Acute 2 (4%) 1 (2%)
Transitional Epithelium, Hyperplasia 1 (2%)
Transitional Epithelium, Hyperplasia, Focal,
Papillary 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 16
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