TDMS Study 92012-04 Pathology Tables
NTP Experiment-Test: 92012-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY 2-METHYLIMIDAZOLE Date: 08/06/96
Route: DOSED FEED Time: 20:32:14
90-DAY
Facility: Microbiological Associates
Chemical CAS #: 693-98-1
Lock Date: 08/31/94
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 92012-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY 2-METHYLIMIDAZOLE Date: 08/06/96
Route: DOSED FEED Time: 20:32:14
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREAT 625 1250 2500 5000 10000
CONTROL PPM PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Survivors
Terminal Sacrifice 10 10 9 10 10 8
Accidently Killed 1 2
Animals Examined Microscopically 10 10 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (1) (10)
Infiltration Cellular, Lymphocyte 1 (10%)
Necrosis, Acute 1 (10%)
Vacuolization Cytoplasmic, Diffuse 1 (10%)
Periportal, Vacuolization Cytoplasmic 6 (60%) 8 (80%)
Stomach, Glandular (10) (1) (10)
Infiltration Cellular, Mixed Cell 1 (10%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Thyroid Gland (10) (9) (8) (9) (10) (10)
Follicular Cell, Hypertrophy 7 (78%) 10 (100%) 10 (100%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (9) (1) (6)
Cyst 6 (67%) 2 (33%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 92012-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY 2-METHYLIMIDAZOLE Date: 08/06/96
Route: DOSED FEED Time: 20:32:14
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREAT 625 1250 2500 5000 10000
CONTROL PPM PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Spleen (10) (10) (10) (10) (10) (10)
Hematopoietic Cell Proliferation 2 (20%) 1 (10%) 1 (10%) 10 (100%) 10 (100%) 10 (100%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (1) (10)
Perivascular, Inflammation, Chronic Active 1 (10%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (10) (10) (10)
Pelvis, Infiltration Cellular, Lymphocyte 1 (10%)
Renal Tubule, Pigmentation, Hemosiderin 3 (30%) 9 (90%) 10 (100%)
Urinary Bladder (10) (1) (10)
Infiltration Cellular, Lymphocyte 2 (20%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 92012-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY 2-METHYLIMIDAZOLE Date: 08/06/96
Route: DOSED FEED Time: 20:32:14
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREAT 625 1250 2500 5000 10000
CONTROL PPM PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Survivors
Terminal Sacrifice 10 9 9 10 10 9
Accidently Killed 1 1 1
Animals Examined Microscopically 10 10 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (1) (1) (10)
Necrosis, Acute 1 (10%)
Periportal, Vacuolization Cytoplasmic 9 (90%) 1 (100%) 10 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Thyroid Gland (10) (9) (10) (9) (10) (10)
Follicular Cell, Hypertrophy 9 (100%) 10 (100%) 10 (100%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Preputial Gland (10) (1) (1) (10)
Cyst 7 (70%) 3 (30%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Spleen (10) (10) (10) (10) (10) (10)
Hematopoietic Cell Proliferation 1 (10%) 10 (100%) 10 (100%) 10 (100%) 10 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 92012-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY 2-METHYLIMIDAZOLE Date: 08/06/96
Route: DOSED FEED Time: 20:32:14
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREAT 625 1250 2500 5000 10000
CONTROL PPM PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Nose (10) (1) (1) (10)
Respiratory Epithelium, Infiltration
Cellular, Mixed Cell 1 (10%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (10) (10) (10)
Cyst 1 (10%)
Renal Tubule, Pigmentation, Hemosiderin 10 (100%) 10 (100%) 10 (100%) 10 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
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