TDMS Study 05028-01 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
HEXACHLOROETHANE
NTP Experiment-Test: 05028-01 Report: PEIRPT03
Study Type: CHRONIC Date: 09/04/94
Route: GAVAGE Time: 09:34:47
Facility: TSI Mason Research
Chemical CAS #: 67-72-1
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05028-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HEXACHLOROETHANE Date: 09/04/94
Route: GAVAGE Time: 09:34:47
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE .08G/KG .16G/KG
FEMALE LF HF
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Dead 4 2 3
Moribund 14 20 15
Accident 1
Survivors
Terminal Sacrifice 32 27 32
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (48) (10) (48)
Parasite Metazoan 2 (4%) 1 (10%) 5 (10%)
Intestine Large, Colon (48) (10) (48)
Parasite Metazoan 8 (17%) 7 (15%)
Intestine Large, Rectum (50) (10) (47)
Parasite Metazoan 4 (8%) 1 (10%) 12 (26%)
Liver (50) (32) (50)
Angiectasis, Focal 1 (2%)
Basophilic Focus 26 (52%) 17 (53%) 28 (56%)
Basophilic Focus, Multiple 1 (3%)
Cytoplasmic Alteration 1 (3%)
Fatty Change 19 (38%) 11 (34%) 20 (40%)
Granuloma 2 (4%) 4 (13%) 5 (10%)
Hemorrhage, Focal 1 (3%)
Hepatodiaphragmatic Nodule 2 (4%) 7 (22%) 4 (8%)
Mixed Cell Focus 1 (2%)
Necrosis, Focal 16 (32%) 5 (16%) 14 (28%)
Bile Duct, Cyst 1 (3%)
Bile Duct, Hyperplasia 21 (42%) 5 (16%) 21 (42%)
Periductular, Inflammation, Chronic 1 (2%) 1 (2%)
Perivascular, Inflammation, Chronic 3 (6%)
Mesentery (7) (5) (5)
Accessory Spleen 1 (20%)
Granuloma 1 (20%)
Hemorrhage 1 (20%)
Fat, Inflammation 1 (20%)
Fat, Necrosis 6 (86%) 3 (60%) 5 (100%)
Pancreas (48) (12) (49)
Inflammation, Chronic, Focal 1 (2%) 1 (8%)
Acinus, Atrophy 9 (19%) 1 (8%) 5 (10%)
Acinus, Hyperplasia, Focal 2 (4%) 2 (4%)
Artery, Inflammation 1 (2%)
Salivary Glands (50) (10) (50)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05028-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HEXACHLOROETHANE Date: 09/04/94
Route: GAVAGE Time: 09:34:47
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE .08G/KG .16G/KG
FEMALE LF HF
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Inflammation, Chronic 1 (10%) 1 (2%)
Acinus, Atrophy, Focal 1 (2%)
Stomach (50) (12) (50)
Lumen, Thrombosis 1 (2%)
Stomach, Forestomach (50) (12) (50)
Acanthosis 1 (8%) 3 (6%)
Hyperkeratosis 1 (2%)
Hyperplasia, Basal Cell, Focal 1 (2%)
Inflammation, Chronic 1 (2%) 1 (8%)
Inflammation, Chronic Active 2 (4%)
Mineralization, Focal 1 (2%)
Stomach, Glandular (49) (10) (50)
Inflammation, Acute 1 (2%)
Inflammation, Chronic, Focal 1 (2%)
Mineralization, Focal 2 (4%) 2 (4%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (11) (50)
Cardiomyopathy 28 (56%) 3 (27%) 27 (54%)
Artery, Inflammation, Chronic, Focal 1 (2%)
Atrium Right, Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (15) (50)
Accessory Adrenal Cortical Nodule 1 (2%)
Atrophy 1 (7%)
Congestion 1 (2%) 1 (7%)
Cytoplasmic Alteration, Focal 7 (14%) 3 (20%) 5 (10%)
Hypertrophy 1 (2%)
Adrenal Gland, Medulla (50) (15) (46)
Hyperplasia, Focal 5 (10%) 7 (15%)
Inflammation, Focal 1 (7%)
Islets, Pancreatic (49) (11) (49)
Hyperplasia 1 (2%)
Pituitary Gland (50) (49) (49)
Pars Distalis, Angiectasis 4 (8%) 1 (2%) 7 (14%)
Pars Distalis, Cyst 25 (50%) 21 (43%) 23 (47%)
Pars Distalis, Hyperplasia, Focal 5 (10%) 11 (22%) 8 (16%)
Pars Intermedia, Angiectasis 3 (6%)
Pars Intermedia, Cyst 1 (2%)
Thyroid Gland (50) (50) (50)
Fibrosis 1 (2%)
Infiltration Cellular, Histiocyte 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05028-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HEXACHLOROETHANE Date: 09/04/94
Route: GAVAGE Time: 09:34:47
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE .08G/KG .16G/KG
FEMALE LF HF
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Pigmentation 1 (2%)
Ultimobranchial Cyst 2 (4%)
C-Cell, Hyperplasia 19 (38%) 11 (22%) 12 (24%)
Follicle, Cyst 1 (2%) 2 (4%)
Follicle, Hyperplasia, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (46) (10) (39)
Abscess 3 (7%) 1 (3%)
Atrophy 1 (2%)
Cyst 1 (2%)
Dilatation 1 (3%)
Hemorrhage 1 (3%)
Hypertrophy 1 (3%)
Inflammation, Acute 1 (2%) 3 (8%)
Inflammation, Chronic 11 (24%) 1 (10%) 4 (10%)
Ovary (50) (14) (50)
Congestion 1 (2%) 1 (7%) 2 (4%)
Cyst 7 (14%) 4 (29%) 4 (8%)
Uterus (48) (25) (50)
Abscess 1 (2%)
Dilatation 5 (10%) 5 (20%) 4 (8%)
Exudate 2 (4%)
Inflammation, Acute, Focal 1 (4%)
Inflammation, Chronic 1 (2%)
Thrombosis 3 (6%) 2 (8%) 2 (4%)
Cervix, Hypertrophy 1 (4%)
Endometrium, Cyst 2 (4%) 1 (2%)
Endometrium, Hyperplasia 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (11) (49)
Hyperplasia 11 (22%) 4 (8%)
Lymph Node (49) (17) (50)
Inguinal, Infiltration Cellular, Plasma Cell 1 (6%)
Lumbar, Congestion 1 (2%)
Lumbar, Infiltration Cellular, Plasma Cell 1 (2%)
Lumbar, Infiltration Cellular, Histiocyte 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05028-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HEXACHLOROETHANE Date: 09/04/94
Route: GAVAGE Time: 09:34:47
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE .08G/KG .16G/KG
FEMALE LF HF
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Mediastinal, Congestion 2 (4%) 1 (6%) 1 (2%)
Mediastinal, Infiltration Cellular, Plasma
Cell 1 (2%)
Mediastinal, Inflammation, Granulomatous 1 (2%)
Mediastinal, Pigmentation 1 (6%)
Pancreatic, Angiectasis 1 (2%)
Pancreatic, Congestion 1 (2%)
Pancreatic, Hemorrhage 1 (6%)
Renal, Congestion 2 (4%) 1 (6%) 2 (4%)
Renal, Granuloma 2 (4%)
Renal, Pigmentation 1 (6%)
Lymph Node, Mandibular (46) (10) (43)
Angiectasis 1 (2%) 2 (5%)
Congestion 4 (9%) 2 (20%)
Infiltration Cellular, Plasma Cell 28 (61%) 3 (30%) 29 (67%)
Lymph Node, Mesenteric (48) (12) (49)
Angiectasis 1 (2%)
Congestion 2 (4%) 2 (4%)
Granuloma 2 (4%)
Hyperplasia, Lymphoid 1 (2%)
Infiltration Cellular, Plasma Cell 1 (2%)
Pigmentation 2 (4%)
Pigmentation, Hemosiderin 3 (6%) 1 (8%) 1 (2%)
Spleen (50) (23) (50)
Congestion 2 (4%)
Hematopoietic Cell Proliferation 17 (34%) 5 (22%) 18 (36%)
Necrosis, Focal 2 (4%) 1 (4%)
Pigmentation, Hemosiderin 5 (10%) 6 (26%) 3 (6%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (48) (28) (46)
Ectasia 3 (6%) 7 (15%)
Galactocele 10 (21%) 16 (57%) 12 (26%)
Hypertrophy 3 (6%)
Inflammation, Focal, Subacute 1 (2%)
Skin (49) (12) (48)
Cyst Epithelial Inclusion 1 (2%)
Inflammation, Chronic 1 (2%)
Subcutaneous Tissue, Abscess 1 (8%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05028-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HEXACHLOROETHANE Date: 09/04/94
Route: GAVAGE Time: 09:34:47
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE .08G/KG .16G/KG
FEMALE LF HF
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (10) (50)
Cranium, Hyperostosis 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (10) (50)
Congestion 1 (2%)
Hemorrhage 1 (2%) 1 (10%) 1 (2%)
Hydrocephalus 2 (4%) 1 (10%) 1 (2%)
Infarct 1 (2%)
Pigmentation, Hemosiderin 1 (2%)
Spinal Cord (38) (38)
Degeneration 1 (3%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (29) (50)
Congestion 2 (4%) 14 (48%) 4 (8%)
Granuloma 2 (4%) 1 (3%) 3 (6%)
Hemorrhage, Focal 1 (2%) 3 (10%) 3 (6%)
Infiltration Cellular, Histiocyte 1 (3%)
Pigmentation, Focal, Hemosiderin 1 (2%)
Alveolar Epithelium, Hyperplasia, Adenomatous 1 (2%)
Alveolar Epithelium, Metaplasia 2 (4%) 1 (3%) 4 (8%)
Alveolus, Atypia Cellular 1 (3%)
Artery, Thrombosis 1 (2%)
Peribronchial, Inflammation, Chronic 29 (58%) 10 (34%) 32 (64%)
Nose (49) (9) (50)
Inflammation, Chronic 16 (33%) 3 (33%) 20 (40%)
Metaplasia, Squamous 39 (80%) 1 (11%) 41 (82%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (6) (6) (6)
Cataract 2 (33%) 1 (17%)
Retinal Detachment 1 (17%)
Cornea, Inflammation, Acute 1 (17%)
Lens, Mineralization, Focal 2 (33%)
Posterior Chamber, Hemorrhage 1 (17%)
Retina, Degeneration 2 (33%) 1 (17%)
Vitreous, Degeneration 1 (17%)
Harderian Gland (3) (1)
Inflammation, Chronic, Focal 2 (67%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05028-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HEXACHLOROETHANE Date: 09/04/94
Route: GAVAGE Time: 09:34:47
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE .08G/KG .16G/KG
FEMALE LF HF
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Casts 1 (2%) 2 (4%)
Inflammation, Chronic 1 (2%) 1 (2%)
Mineralization 14 (28%) 22 (44%) 13 (26%)
Nephropathy 22 (44%) 42 (84%) 45 (90%)
Renal Tubule, Cyst 2 (4%)
Renal Tubule, Hyperplasia 1 (2%)
Renal Tubule, Pigmentation 2 (4%) 2 (4%) 3 (6%)
Renal Tubule, Regeneration 2 (4%) 1 (2%)
Urinary Bladder (46) (11) (47)
Hyperplasia 1 (9%)
Inflammation, Chronic 2 (18%)
Transitional Epithelium, Hyperplasia 1 (2%)
Transitional Epithelium, Hyperplasia,
Squamous 1 (9%)
Wall, Inflammation, Chronic Active 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05028-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HEXACHLOROETHANE Date: 09/04/94
Route: GAVAGE Time: 09:34:47
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE .01G/KG .02G/KG
MALE LM HM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Moribund 16 14 19
Accident 1 1
Dead 2 6 4
Gavage Death 1
Survivors
Terminal Sacrifice 31 29 26
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (13) (49)
Foreign Body 1 (8%)
Perforation 1 (8%)
Periesophageal Tissue, Inflammation, Acute 1 (8%)
Periesophageal Tissue, Inflammation, Chronic
Active 1 (2%)
Intestine Large, Cecum (49) (12) (45)
Parasite Metazoan 4 (8%) 1 (8%) 2 (4%)
Intestine Large, Colon (50) (13) (46)
Parasite Metazoan 10 (20%) 1 (8%) 4 (9%)
Intestine Large, Rectum (50) (12) (47)
Parasite Metazoan 10 (20%) 1 (8%) 8 (17%)
Intestine Small, Ileum (49) (14) (47)
Hyperplasia, Lymphoid 1 (2%)
Parasite Metazoan 1 (2%) 1 (2%)
Liver (50) (31) (50)
Angiectasis 1 (2%)
Basophilic Focus 11 (22%) 10 (32%) 26 (52%)
Congestion 1 (2%) 2 (6%)
Cytoplasmic Alteration, Focal 2 (4%) 2 (6%) 2 (4%)
Fatty Change 27 (54%) 14 (45%) 22 (44%)
Fibrosis, Focal 1 (2%)
Hepatodiaphragmatic Nodule 1 (2%) 3 (10%) 2 (4%)
Hyperplasia 1 (2%)
Hyperplasia, Focal 1 (3%)
Mineralization, Focal 1 (2%)
Necrosis, Focal 20 (40%) 3 (10%) 23 (46%)
Bile Duct, Hyperplasia 40 (80%) 24 (77%) 42 (84%)
Centrilobular, Necrosis, Focal 1 (3%)
Serosa, Proliferation 1 (3%)
Mesentery (1) (5) (5)
Fat, Necrosis 2 (40%) 2 (40%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05028-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HEXACHLOROETHANE Date: 09/04/94
Route: GAVAGE Time: 09:34:47
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE .01G/KG .02G/KG
MALE LM HM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Pancreas (50) (18) (50)
Inflammation, Chronic 1 (2%)
Acinus, Atrophy 23 (46%) 3 (17%) 11 (22%)
Acinus, Hyperplasia 5 (10%) 5 (10%)
Artery, Inflammation 1 (2%)
Duct, Hyperplasia, Focal 1 (6%)
Salivary Glands (50) (13) (50)
Inflammation, Chronic 1 (2%)
Karyomegaly, Focal 2 (4%)
Stomach (50) (19) (49)
Serosa, Fibrosis 1 (2%)
Serosa, Inflammation, Chronic Active 1 (2%)
Stomach, Forestomach (48) (18) (49)
Acanthosis 1 (2%) 3 (17%) 3 (6%)
Cyst Epithelial Inclusion 1 (2%)
Hyperkeratosis 4 (8%) 3 (17%) 2 (4%)
Hyperplasia, Basal Cell 1 (2%) 1 (6%) 1 (2%)
Inflammation, Focal 2 (4%)
Ulcer 2 (4%) 3 (17%) 3 (6%)
Epithelium, Hyperplasia 1 (2%)
Stomach, Glandular (50) (19) (49)
Erosion 1 (2%)
Infiltration Cellular, Lymphocyte 2 (11%) 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (15) (50)
Cardiomyopathy 37 (74%) 14 (93%) 43 (86%)
Hemorrhage, Focal 1 (7%)
Inflammation, Chronic 1 (2%) 1 (7%) 1 (2%)
Mineralization 1 (2%)
Pigmentation, Hemosiderin 1 (2%) 1 (7%)
Atrium, Dilatation 2 (13%) 3 (6%)
Atrium, Thrombosis 1 (2%) 5 (10%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (50) (50)
Accessory Adrenal Cortical Nodule 1 (2%)
Cytoplasmic Alteration, Focal 6 (12%) 1 (2%) 2 (4%)
Hyperplasia, Focal 3 (6%) 5 (10%) 2 (4%)
Hypertrophy 1 (2%)
Vacuolization Cytoplasmic 2 (4%) 8 (16%) 2 (4%)
Adrenal Gland, Medulla (50) (45) (49)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05028-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HEXACHLOROETHANE Date: 09/04/94
Route: GAVAGE Time: 09:34:47
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE .01G/KG .02G/KG
MALE LM HM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Hyperplasia, Focal 6 (12%) 4 (9%) 10 (20%)
Thrombosis 1 (2%)
Islets, Pancreatic (50) (17) (50)
Hyperplasia 4 (8%)
Parathyroid Gland (41) (40) (43)
Cyst 1 (2%)
Hyperplasia 1 (2%)
Pituitary Gland (49) (50) (48)
Pars Distalis, Angiectasis 2 (4%)
Pars Distalis, Cyst 1 (2%) 1 (2%) 2 (4%)
Pars Distalis, Hemorrhage 1 (2%) 1 (2%)
Pars Distalis, Hyperplasia, Focal 11 (22%) 13 (26%) 13 (27%)
Pars Distalis, Pigmentation, Hemosiderin 1 (2%) 1 (2%)
Pars Distalis, Vacuolization Cytoplasmic 1 (2%)
Pars Intermedia, Cyst 1 (2%) 1 (2%)
Pars Nervosa, Cyst 1 (2%)
Thyroid Gland (49) (50) (50)
C-Cell, Hyperplasia 10 (20%) 10 (20%) 11 (22%)
Follicle, Cyst 2 (4%) 3 (6%) 4 (8%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (49) (14) (50)
Atrophy 1 (2%) 2 (4%)
Dilatation, Focal 1 (2%)
Inflammation, Chronic 1 (2%)
Preputial Gland (46) (17) (49)
Abscess 1 (6%) 3 (6%)
Atrophy 1 (2%)
Ectasia 2 (4%) 2 (4%)
Hyperplasia 1 (2%)
Inflammation, Acute 1 (2%) 4 (8%)
Inflammation, Chronic 29 (63%) 6 (35%) 18 (37%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Inflammation, Granulomatous 1 (2%)
Prostate (50) (13) (48)
Abscess 1 (8%)
Atrophy 2 (4%)
Hyperplasia, Focal 2 (4%) 6 (13%)
Inflammation, Acute 3 (6%) 2 (15%) 1 (2%)
Inflammation, Chronic 8 (16%) 5 (38%) 5 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05028-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HEXACHLOROETHANE Date: 09/04/94
Route: GAVAGE Time: 09:34:47
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE .01G/KG .02G/KG
MALE LM HM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Inflammation, Chronic Active 1 (2%)
Metaplasia, Squamous 1 (2%)
Seminal Vesicle (50) (23) (48)
Atrophy 27 (54%) 12 (52%) 29 (60%)
Dilatation 2 (9%)
Testes (49) (46) (50)
Edema 1 (2%)
Necrosis 1 (2%)
Interstitial Cell, Hyperplasia 2 (4%)
Seminiferous Tubule, Atrophy 8 (16%) 4 (9%) 3 (6%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (13) (49)
Hyperplasia 2 (4%) 2 (15%) 7 (14%)
Lymph Node (50) (31) (50)
Axillary, Congestion 1 (3%)
Inguinal, Angiectasis 1 (2%)
Lumbar, Congestion 1 (3%)
Lumbar, Hyperplasia 1 (2%)
Lumbar, Infiltration Cellular, Plasma Cell 1 (2%)
Lumbar, Infiltration Cellular, Histiocyte 1 (2%)
Mediastinal, Congestion 3 (6%) 4 (13%) 3 (6%)
Mediastinal, Infiltration Cellular, Plasma
Cell 2 (6%)
Mediastinal, Pigmentation, Hemosiderin 1 (2%)
Pancreatic, Congestion 1 (2%) 1 (3%)
Pancreatic, Pigmentation, Hemosiderin 1 (2%)
Renal, Congestion 1 (2%) 2 (6%)
Renal, Hyperplasia, Lymphoid 1 (3%)
Renal, Infiltration Cellular, Histiocyte 2 (4%)
Renal, Pigmentation, Hemosiderin 1 (2%)
Lymph Node, Mandibular (45) (23) (44)
Angiectasis 3 (7%) 2 (5%)
Congestion 2 (4%) 5 (22%) 1 (2%)
Infiltration Cellular, Plasma Cell 26 (58%) 16 (70%) 29 (66%)
Lymphatic, Angiectasis 4 (17%)
Lymph Node, Mesenteric (50) (15) (48)
Congestion 2 (4%) 2 (13%) 2 (4%)
Cyst 1 (2%)
Hyperplasia, Lymphoid 2 (4%)
Infiltration Cellular, Plasma Cell 1 (7%)
Infiltration Cellular, Histiocyte 1 (2%)
Necrosis 1 (7%)
Pigmentation, Hemosiderin 1 (2%)
Spleen (49) (28) (50)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05028-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HEXACHLOROETHANE Date: 09/04/94
Route: GAVAGE Time: 09:34:47
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE .01G/KG .02G/KG
MALE LM HM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Congestion 1 (2%) 1 (4%) 1 (2%)
Depletion Lymphoid 1 (2%)
Fibrosis 3 (11%)
Fibrosis, Focal 3 (6%) 1 (4%) 1 (2%)
Hematopoietic Cell Proliferation 6 (12%) 4 (14%) 8 (16%)
Necrosis 1 (2%)
Pigmentation, Hemosiderin 4 (8%) 5 (18%) 11 (22%)
Thymus (47) (11) (43)
Congestion 2 (18%)
Hyperplasia, Lymphoid 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (33) (16) (23)
Ectasia 1 (3%)
Galactocele 1 (3%) 4 (25%)
Hemorrhage 1 (4%)
Hyperplasia, Glandular 1 (3%)
Skin (48) (21) (50)
Cyst Epithelial Inclusion 1 (2%) 3 (6%)
Hyperkeratosis 1 (2%)
Subcutaneous Tissue, Fibrosis 1 (2%)
Subcutaneous Tissue, Necrosis 1 (5%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (13) (50)
Tarsal, Hyperostosis 1 (2%)
Skeletal Muscle (4) (2) (2)
Back, Hemorrhage, Focal 1 (25%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (13) (50)
Hemorrhage, Focal 4 (8%) 4 (31%) 3 (6%)
Hydrocephalus 5 (10%) 5 (10%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (24) (50)
Congestion 2 (4%) 7 (29%) 2 (4%)
Edema 1 (4%)
Embolus 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05028-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HEXACHLOROETHANE Date: 09/04/94
Route: GAVAGE Time: 09:34:47
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE .01G/KG .02G/KG
MALE LM HM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Foreign Body 1 (4%) 1 (2%)
Fungus 1 (2%)
Granuloma 1 (2%) 1 (4%) 4 (8%)
Hemorrhage, Focal 4 (17%)
Infiltration Cellular, Histiocyte 1 (4%)
Alveolar Epithelium, Hyperplasia, Adenomatous 1 (2%) 2 (4%)
Alveolar Epithelium, Metaplasia, Focal 1 (4%) 2 (4%)
Artery, Ectasia 1 (2%)
Peribronchial, Inflammation, Chronic 34 (68%) 5 (21%) 32 (64%)
Pleura, Inflammation, Acute 1 (4%)
Nose (50) (13) (50)
Foreign Body 1 (2%)
Fungus 3 (6%) 1 (8%) 2 (4%)
Hemorrhage, Focal 1 (8%)
Inflammation, Acute 1 (8%) 1 (2%)
Inflammation, Chronic 36 (72%) 7 (54%) 30 (60%)
Inflammation, Chronic Active 1 (2%)
Metaplasia, Squamous 34 (68%) 1 (8%) 33 (66%)
Lymphatic, Angiectasis 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1) (2)
Inflammation, Chronic, Focal 1 (100%)
Eye (5) (3) (2)
Cataract 3 (60%) 1 (33%)
Retina, Degeneration 1 (20%) 1 (33%) 1 (50%)
Sclera, Mineralization, Focal 1 (20%)
Vitreous, Hemorrhage 1 (50%)
Harderian Gland (2)
Inflammation, Chronic 1 (50%)
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URINARY SYSTEM
Kidney (50) (50) (50)
Casts 2 (4%)
Congestion 2 (4%)
Cytomegaly 2 (4%)
Hemorrhage, Focal 1 (2%)
Hyperplasia 1 (2%) 1 (2%)
Inflammation, Chronic 2 (4%)
Mineralization 2 (4%) 15 (30%) 32 (64%)
Nephropathy 48 (96%) 48 (96%) 47 (94%)
Artery, Inflammation, Chronic 1 (2%)
Pelvis, Inflammation, Acute 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 05028-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HEXACHLOROETHANE Date: 09/04/94
Route: GAVAGE Time: 09:34:47
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FISCHER 344 RATS MALE VEHICLE .01G/KG .02G/KG
MALE LM HM
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URINARY SYSTEM - CONT
Pelvis, Transitional Epithelium, Hyperplasia 7 (14%) 7 (14%)
Renal Tubule, Cyst 2 (4%) 3 (6%) 1 (2%)
Renal Tubule, Hyperplasia 2 (4%) 4 (8%) 11 (22%)
Renal Tubule, Necrosis, Focal 1 (2%)
Renal Tubule, Pigmentation 1 (2%) 4 (8%) 5 (10%)
Renal Tubule, Regeneration 1 (2%) 3 (6%)
Urinary Bladder (47) (10) (46)
Concretion 4 (9%) 1 (10%) 2 (4%)
Lumen, Thrombosis 1 (10%)
Transitional Epithelium, Hyperplasia 1 (10%) 1 (2%)
Wall, Inflammation, Acute 1 (10%)
Wall, Inflammation, Chronic Active 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
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