TDMS Study 05028-01 Pathology Tables
NTP Experiment-Test: 05028-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROETHANE Date: 05/05/97
Route: GAVAGE Time: 08:33:49
Facility: TSI Mason Research
Chemical CAS #: 67-72-1
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05028-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROETHANE Date: 05/05/97
Route: GAVAGE Time: 08:33:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 3| 3| 5| 4| 4| 3| 3| 1| 4| 4| 4| 4| 0| 3| 3| 8| 2| 0| 4| 4| 4| 3| 3|
| 2| 2| 7| 7| 7| 2| 1| 9| 8| 8| 1| 1| 1| 1| 7| 8| 7| 2| 3| 9| 1| 1| 1| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + + + + + + + + A + + + + + + + + + +|
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + + + + + + + + A + + + + + + + + + +|
Parasite Metazoan | 3 4 2 3 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 4 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + M + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Basophilic Focus | X X X X X X X X X X X X |
Fatty Change | 4 2 2 2 2 3 1 2 |
Granuloma | 2 3|
Hepatodiaphragmatic Nodule | X |
Mixed Cell Focus | |
Necrosis, Focal | 2 2 2 2 1 2 |
Bile Duct, Hyperplasia | 2 2 1 2 2 2 2 2 2 2 |
Periductular, Inflammation, Chronic | |
Perivascular, Inflammation, Chronic | 1 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 4 4 |
__________________________________________________________________________|
Pancreas | + + + + A + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
Acinus, Atrophy | 2 1 2 2 |
Acinus, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Focal | 3 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Basal Cell, Focal | 3 |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + A + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 2 3 1 3 4 2 1 2 2 3 2 1 2 2 3|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05028-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROETHANE Date: 05/05/97
Route: GAVAGE Time: 08:33:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 3| 3| 5| 4| 4| 3| 3| 1| 4| 4| 4| 4| 0| 3| 3| 8| 2| 0| 4| 4| 4| 3| 3|
| 2| 2| 7| 7| 7| 2| 1| 9| 8| 8| 1| 1| 1| 1| 7| 8| 7| 2| 3| 9| 1| 1| 1| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Cytoplasmic Alteration, Focal | 2 2 4 |
Hypertrophy | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 4 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + A + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + M + + + M M + + + + + + + + + + M + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 4 4 |
Pars Distalis, Cyst | X X X X X X X X X X X X X X |
Pars Distalis, Hyperplasia, Focal | 2 2 3 2 |
Pars Intermedia, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Infiltration Cellular, Histiocyte | 4 |
Pigmentation | 3 |
C-Cell, Hyperplasia | 3 2 3 4 4 2 2 2 4 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + M + M + + + + + + + + + + +|
Abscess | 4 4 |
Atrophy | 3 |
Cyst | |
Inflammation, Acute | 1 |
Inflammation, Chronic | 3 1 3 4 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Cyst | X X 3 X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 |
Exudate | |
Thrombosis | X X X |
Endometrium, Cyst | X X |
Endometrium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 4 2 4 2 |
__________________________________________________________________________|
Lymph Node | + + + + A + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05028-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROETHANE Date: 05/05/97
Route: GAVAGE Time: 08:33:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 3| 3| 5| 4| 4| 3| 3| 1| 4| 4| 4| 4| 0| 3| 3| 8| 2| 0| 4| 4| 4| 3| 3|
| 2| 2| 7| 7| 7| 2| 1| 9| 8| 8| 1| 1| 1| 1| 7| 8| 7| 2| 3| 9| 1| 1| 1| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lumbar, Congestion | 3 |
Lumbar, Infiltration Cellular, | |
Plasma Cell | 2 |
Lumbar, Infiltration Cellular, | |
Histiocyte | 2 |
Mediastinal, Congestion | 3 |
Mediastinal, Infiltration Cellular, | |
Plasma Cell | 3 |
Mediastinal, Inflammation, | |
Granulomatous | |
Renal, Congestion | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + A + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 |
Congestion | 3 4 |
Infiltration Cellular, Plasma Cell | 2 2 3 3 2 4 3 2 2 3 3 4 2 4 3|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + A + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Congestion | |
Infiltration Cellular, Plasma Cell | 3 |
Pigmentation, Hemosiderin | 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 2 3 2 2 2|
Necrosis, Focal | 4 |
Pigmentation, Hemosiderin | 2 4 |
__________________________________________________________________________|
Thymus | + + + + + + + + M + I M M M + M + + + + + + M + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M + + + + + + + + + + + + + + + + + + + +|
Ectasia | 4 3 |
Galactocele | X X X X X X X|
Hypertrophy | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Hydrocephalus | 2 |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Peripheral Nerve | + M + + + + + + + + + + + + M + + + +|
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05028-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROETHANE Date: 05/05/97
Route: GAVAGE Time: 08:33:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 3| 3| 5| 4| 4| 3| 3| 1| 4| 4| 4| 4| 0| 3| 3| 8| 2| 0| 4| 4| 4| 3| 3|
| 2| 2| 7| 7| 7| 2| 1| 9| 8| 8| 1| 1| 1| 1| 7| 8| 7| 2| 3| 9| 1| 1| 1| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Granuloma | 3 |
Hemorrhage, Focal | |
Pigmentation, Focal, Hemosiderin | 2 |
Alveolar Epithelium, Hyperplasia, | |
Adenomatous | 2 |
Alveolar Epithelium, Metaplasia | 3 |
Peribronchial, Inflammation, Chronic | 2 2 2 2 2 2 1 2 2 1 2 2 2 2 3 3|
__________________________________________________________________________|
Nose | + + + M + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 1 1 3 3|
Metaplasia, Squamous | 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 3 2 2 4|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 3 |
Retina, Degeneration | 3 |
__________________________________________________________________________|
Zymbal's Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Casts | |
Mineralization | 1 1 2 2 1 1 1 2 |
Nephropathy | 2 2 1 2 1 2 2 1 2 1 1|
Renal Tubule, Pigmentation | |
__________________________________________________________________________|
Urinary Bladder | + + + + A + + + + + + M + + A + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05028-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROETHANE Date: 05/05/97
Route: GAVAGE Time: 08:33:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 6| 6| 5| 7| 7| 6| 5| 5| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 4| 3| 2| 6| 3| 3| 9| 7| 4| 4| 4| 6| 2| 5| 4| 1| 0| 8| 0| 4| 4| 4| 4| 3| |
| 1| 2| 8| 2| 8| 7| 7| 3| 1| 3| 1| 1| 1| 5| 2| 1| 0| 3| 5| 6| 1| 1| 2| 1| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + M + M + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Parasite Metazoan | 3 | 2 2.5|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Parasite Metazoan | 2 2 2 | 8 2.5|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | 3 2 | 4 2.8|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis, Focal | 3 | 1 3.0|
Basophilic Focus | X X X X X X X X X X X X X X | 26 |
Fatty Change | 2 2 1 2 3 3 2 2 2 2 3 | 19 2.2|
Granuloma | | 2 2.5|
Hepatodiaphragmatic Nodule | X | 2 |
Mixed Cell Focus | X | 1 |
Necrosis, Focal | 1 3 2 1 2 2 2 2 2 2 | 16 1.9|
Bile Duct, Hyperplasia | 2 1 2 2 2 2 2 3 2 3 3| 21 2.0|
Periductular, Inflammation, Chronic | 2 | 1 2.0|
Perivascular, Inflammation, Chronic | 2 1 | 3 1.3|
__________________________________________________________________________|____________|
Mesentery | + + + + + | 7 |
Fat, Necrosis | 4 4 4 4 | 6 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + M + + + + + +| 48 |
Inflammation, Chronic, Focal | 2 | 1 2.0|
Acinus, Atrophy | 2 3 1 2 2 | 9 1.9|
Acinus, Hyperplasia, Focal | 2 | 2 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Basal Cell, Focal | | 1 3.0|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Mineralization, Focal | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 05028-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROETHANE Date: 05/05/97
Route: GAVAGE Time: 08:33:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 6| 6| 5| 7| 7| 6| 5| 5| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 4| 3| 2| 6| 3| 3| 9| 7| 4| 4| 4| 6| 2| 5| 4| 1| 0| 8| 0| 4| 4| 4| 4| 3| |
| 1| 2| 8| 2| 8| 7| 7| 3| 1| 3| 1| 1| 1| 5| 2| 1| 0| 3| 5| 6| 1| 1| 2| 1| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 1 2 3 1 2 1 2 2 2 2 | 28 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 2.0|
Cytoplasmic Alteration, Focal | 4 3 2 2 | 7 2.7|
Hypertrophy | 3 | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 2 4 | 5 2.8|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M + + + + + + + M M M M M + + + + + M +| 38 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | 3 | 4 3.3|
Pars Distalis, Cyst | X X X X X X X X X X X | 25 |
Pars Distalis, Hyperplasia, Focal | 3 | 5 2.4|
Pars Intermedia, Cyst | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | | 1 2.0|
Infiltration Cellular, Histiocyte | | 1 4.0|
Pigmentation | | 1 3.0|
C-Cell, Hyperplasia | 2 3 4 3 4 3 3 3 1 | 19 2.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + M + + + + + + + + + + M + + + +| 46 |
Abscess | 4 | 3 4.0|
Atrophy | | 1 3.0|
Cyst | X | 1 |
Inflammation, Acute | | 1 1.0|
Inflammation, Chronic | 1 2 1 2 3 2| 11 2.2|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 1 | 1 1.0|
Cyst | X X X | 7 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + M + + M + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05028-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROETHANE Date: 05/05/97
Route: GAVAGE Time: 08:33:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 6| 6| 5| 7| 7| 6| 5| 5| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 4| 3| 2| 6| 3| 3| 9| 7| 4| 4| 4| 6| 2| 5| 4| 1| 0| 8| 0| 4| 4| 4| 4| 3| |
| 1| 2| 8| 2| 8| 7| 7| 3| 1| 3| 1| 1| 1| 5| 2| 1| 0| 3| 5| 6| 1| 1| 2| 1| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Dilatation | 4 4 4 3 | 5 3.8|
Exudate | 3 X | 2 3.0|
Thrombosis | | 3 |
Endometrium, Cyst | | 2 |
Endometrium, Hyperplasia | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 3 3 2 2 2 | 11 2.6|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lumbar, Congestion | | 1 3.0|
Lumbar, Infiltration Cellular, | | |
Plasma Cell | | 1 2.0|
Lumbar, Infiltration Cellular, | | |
Histiocyte | | 1 2.0|
Mediastinal, Congestion | 2 | 2 2.5|
Mediastinal, Infiltration Cellular, | | |
Plasma Cell | | 1 3.0|
Mediastinal, Inflammation, | | |
Granulomatous | 3 | 1 3.0|
Renal, Congestion | 3 | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + M M + + + + M + + + + + + + + + + + +| 46 |
Angiectasis | | 1 4.0|
Congestion | 3 3| 4 3.3|
Infiltration Cellular, Plasma Cell | 3 3 2 2 2 3 2 3 2 2 3 3 2 | 28 2.6|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + M + + + + +| 48 |
Angiectasis | | 1 3.0|
Congestion | 2 1 | 2 1.5|
Infiltration Cellular, Plasma Cell | | 1 3.0|
Pigmentation, Hemosiderin | 3 | 3 2.3|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 2 3 4 3 2 3 2 2 2 2 | 17 2.4|
Necrosis, Focal | 4 | 2 4.0|
Pigmentation, Hemosiderin | 2 3 2 | 5 2.6|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + M + + + + + + + M + +| 41 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| 48 |
Ectasia | 4 | 3 3.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05028-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROETHANE Date: 05/05/97
Route: GAVAGE Time: 08:33:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 6| 6| 5| 7| 7| 6| 5| 5| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 4| 3| 2| 6| 3| 3| 9| 7| 4| 4| 4| 6| 2| 5| 4| 1| 0| 8| 0| 4| 4| 4| 4| 3| |
| 1| 2| 8| 2| 8| 7| 7| 3| 1| 3| 1| 1| 1| 5| 2| 1| 0| 3| 5| 6| 1| 1| 2| 1| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Galactocele | X X X| 10 |
Hypertrophy | 2 2 3 | 3 2.3|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + M + + + + + + +| 49 |
Cyst Epithelial Inclusion | | 1 |
Inflammation, Chronic | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 3.0|
Hydrocephalus | 2 | 2 2.0|
Pigmentation, Hemosiderin | 2 | 1 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + M + + + + + + M + + + + +| 33 |
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + +| 38 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 2 | 2 2.0|
Granuloma | 3 | 2 3.0|
Hemorrhage, Focal | 3 | 1 3.0|
Pigmentation, Focal, Hemosiderin | | 1 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Adenomatous | | 1 2.0|
Alveolar Epithelium, Metaplasia | 3 | 2 3.0|
Peribronchial, Inflammation, Chronic | 2 2 2 2 2 1 2 2 1 2 2 1 2 | 29 1.9|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | 2 2 1 2 2 2 3 1 2 1 | 16 1.9|
Metaplasia, Squamous | 2 2 2 2 2 2 2 2 1 2 2 2 2 2 3 2 2 2 2 4| 39 2.1|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + + | 6 |
Cataract | 3 | 2 3.0|
Retina, Degeneration | 2 | 2 2.5|
__________________________________________________________________________|____________|
Zymbal's Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05028-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROETHANE Date: 05/05/97
Route: GAVAGE Time: 08:33:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 6| 6| 5| 7| 7| 6| 5| 5| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 4| 3| 2| 6| 3| 3| 9| 7| 4| 4| 4| 6| 2| 5| 4| 1| 0| 8| 0| 4| 4| 4| 4| 3| |
| 1| 2| 8| 2| 8| 7| 7| 3| 1| 3| 1| 1| 1| 5| 2| 1| 0| 3| 5| 6| 1| 1| 2| 1| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Casts | 3 | 1 3.0|
Mineralization | 2 2 1 1 1 1 | 14 1.4|
Nephropathy | 2 2 1 1 1 1 2 2 1 3 3| 22 1.6|
Renal Tubule, Pigmentation | 2 3 | 2 2.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + A + + + + + +| 46 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05028-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROETHANE Date: 05/05/97
Route: GAVAGE Time: 08:33:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 3| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 3| 3| 3| 9| 3| 3| 3| 2| 6| 3| 3| 3| 9| 4| 3| 3| 3| 3| 6| 3| 3| 2| 6| 3|
| 1| 1| 1| 1| 6| 1| 1| 1| 2| 8| 2| 2| 2| 3| 8| 2| 2| 2| 2| 0| 3| 2| 2| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
.08 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + +|
__________________________________________________________________________|
Intestine Large | + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + +|
Basophilic Focus | 1 1 X X X X X|
Basophilic Focus, Multiple | X |
Cytoplasmic Alteration | 2 |
Fatty Change | 1 2 1 4 2 2|
Granuloma | 3 2|
Hemorrhage, Focal | |
Hepatodiaphragmatic Nodule | X X X X |
Necrosis, Focal | 2 3 |
Bile Duct, Cyst | |
Bile Duct, Hyperplasia | 2 |
__________________________________________________________________________|
Mesentery | + |
Accessory Spleen | |
Hemorrhage | 3 |
Fat, Inflammation | |
Fat, Necrosis | 4 |
__________________________________________________________________________|
Pancreas | + + + + + +|
Inflammation, Chronic, Focal | |
Acinus, Atrophy | 1|
__________________________________________________________________________|
Salivary Glands | + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Stomach | + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + +|
Acanthosis | 3 |
Inflammation, Chronic | |
__________________________________________________________________________|
Stomach, Glandular | + + + +|
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + +|
Cardiomyopathy | 2 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05028-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROETHANE Date: 05/05/97
Route: GAVAGE Time: 08:33:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 3| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 3| 3| 3| 9| 3| 3| 3| 2| 6| 3| 3| 3| 9| 4| 3| 3| 3| 3| 6| 3| 3| 2| 6| 3|
| 1| 1| 1| 1| 6| 1| 1| 1| 2| 8| 2| 2| 2| 3| 8| 2| 2| 2| 2| 0| 3| 2| 2| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
.08 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + +|
Atrophy | 4 |
Congestion | |
Cytoplasmic Alteration, Focal | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + +|
Inflammation, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M M + + + M M + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | X X X X X X X X X |
Pars Distalis, Hyperplasia, Focal | 2 3 3 2 2 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 3 3 1 3 1 2 2 1 |
Follicle, Cyst | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + M +|
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Ovary | + + + + +|
Congestion | |
Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + +|
Dilatation | 4 4 3 3 |
Inflammation, Acute, Focal | |
Thrombosis | X |
Cervix, Hypertrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + +|
Inguinal, Infiltration Cellular, | |
Plasma Cell | 3 |
Mediastinal, Congestion | 2 |
Mediastinal, Pigmentation | |
Pancreatic, Hemorrhage | |
Renal, Congestion | 3 |
Renal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + +|
Congestion | 2 |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05028-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROETHANE Date: 05/05/97
Route: GAVAGE Time: 08:33:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 3| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 3| 3| 3| 9| 3| 3| 3| 2| 6| 3| 3| 3| 9| 4| 3| 3| 3| 3| 6| 3| 3| 2| 6| 3|
| 1| 1| 1| 1| 6| 1| 1| 1| 2| 8| 2| 2| 2| 3| 8| 2| 2| 2| 2| 0| 3| 2| 2| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
.08 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Infiltration Cellular, Plasma Cell | 3|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + +|
Pigmentation, Hemosiderin | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + +|
Hematopoietic Cell Proliferation | 4 |
Necrosis, Focal | |
Pigmentation, Hemosiderin | 2 3 |
__________________________________________________________________________|
Thymus | + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + +|
Galactocele | X X X X X X X X |
__________________________________________________________________________|
Skin | + + + + +|
Subcutaneous Tissue, Abscess | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + +|
Hemorrhage | |
Hydrocephalus | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + +|
Congestion | 2 2 2 1 2 2 1 3 2 2|
Granuloma | 4 |
Hemorrhage, Focal | |
Infiltration Cellular, Histiocyte | 4 |
Alveolar Epithelium, Metaplasia | 3 |
Alveolus, Atypia Cellular | |
Peribronchial, Inflammation, Chronic | 2 2 2 2 2 2|
__________________________________________________________________________|
Nose | + + + +|
Inflammation, Chronic | |
Metaplasia, Squamous | 3 |
__________________________________________________________________________|
Trachea | + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
Lens, Mineralization, Focal | 2 |
Posterior Chamber, Hemorrhage | 3 |
Retina, Degeneration | 3 |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05028-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROETHANE Date: 05/05/97
Route: GAVAGE Time: 08:33:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 3| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 3| 3| 3| 9| 3| 3| 3| 2| 6| 3| 3| 3| 9| 4| 3| 3| 3| 3| 6| 3| 3| 2| 6| 3|
| 1| 1| 1| 1| 6| 1| 1| 1| 2| 8| 2| 2| 2| 3| 8| 2| 2| 2| 2| 0| 3| 2| 2| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
.08 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Inflammation, Chronic, Focal | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2|
Nephropathy | 1 1 1 2 1 3 2 2 1 2 1 1 1 1 1 2 2 2 2 2 1 2 2|
Renal Tubule, Hyperplasia | 1 |
Renal Tubule, Pigmentation | 1 |
Renal Tubule, Regeneration | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + +|
Hyperplasia | |
Inflammation, Chronic | |
Transitional Epithelium, Hyperplasia,| |
Squamous | |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05028-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROETHANE Date: 05/05/97
Route: GAVAGE Time: 08:33:49
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 5| 5| 5| 7| 7| 6| 6| 5| |
DAY ON TEST | 3| 3| 6| 4| 1| 3| 3| 3| 6| 6| 3| 3| 3| 3| 7| 3| 3| 8| 6| 0| 3| 0| 4| 1| 9| |
| 2| 2| 4| 7| 6| 3| 3| 3| 0| 0| 4| 4| 4| 3| 2| 4| 4| 2| 6| 3| 4| 0| 7| 2| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
.08 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + M + +| 9 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + +| 10 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + +| 10 |
Parasite Metazoan | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + +| 10 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + +| 10 |
Parasite Metazoan | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + +| 10 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + +| 10 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + +| 10 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + +| 10 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + +| 32 |
Basophilic Focus | X X X 3 X X X X X X| 17 1.7|
Basophilic Focus, Multiple | | 1 |
Cytoplasmic Alteration | | 1 2.0|
Fatty Change | 1 2 1 2 2| 11 1.8|
Granuloma | 3 2 | 4 2.5|
Hemorrhage, Focal | 2 | 1 2.0|
Hepatodiaphragmatic Nodule | X X X | 7 |
Necrosis, Focal | 3 3 1 | 5 2.4|
Bile Duct, Cyst | 4 | 1 4.0|
Bile Duct, Hyperplasia | 2 2 2 1| 5 1.8|
__________________________________________________________________________|____________|
Mesentery | + + + + | 5 |
Accessory Spleen | X | 1 |
Hemorrhage | | 1 3.0|
Fat, Inflammation | 3 | 1 3.0|
Fat, Necrosis | 4 4 | 3 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + +| 12 |
Inflammation, Chronic, Focal | 1 | 1 1.0|
Acinus, Atrophy | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + +| 10 |
Inflammation, Chronic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + +| 12 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + +| 12 |
Acanthosis | | 1 3.0|
Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + +| 10 |
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05028-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROETHANE Date: 05/05/97
Route: GAVAGE Time: 08:33:49
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 5| 5| 5| 7| 7| 6| 6| 5| |
DAY ON TEST | 3| 3| 6| 4| 1| 3| 3| 3| 6| 6| 3| 3| 3| 3| 7| 3| 3| 8| 6| 0| 3| 0| 4| 1| 9| |
| 2| 2| 4| 7| 6| 3| 3| 3| 0| 0| 4| 4| 4| 3| 2| 4| 4| 2| 6| 3| 4| 0| 7| 2| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
.08 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + +| 11 |
Cardiomyopathy | 2| 3 1.7|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + +| 15 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + +| 15 |
Atrophy | | 1 4.0|
Congestion | 2 | 1 2.0|
Cytoplasmic Alteration, Focal | 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + +| 15 |
Inflammation, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + +| 11 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + + + M + M M + + + + + M + + + + M| 40 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + M + + + + + + +| 49 |
Pars Distalis, Angiectasis | 3 | 1 3.0|
Pars Distalis, Cyst | X X X X X X X X X X X X| 21 |
Pars Distalis, Hyperplasia, Focal | 3 2 3 3 2 | 11 2.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 2 | 11 1.8|
Follicle, Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + +| 10 |
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + +| 14 |
Congestion | 2 | 1 2.0|
Cyst | X X X | 4 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + +| 25 |
Dilatation | 3 | 5 3.4|
Inflammation, Acute, Focal | 2 | 1 2.0|
Thrombosis | X | 2 |
Cervix, Hypertrophy | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + +| 11 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05028-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROETHANE Date: 05/05/97
Route: GAVAGE Time: 08:33:49
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 5| 5| 5| 7| 7| 6| 6| 5| |
DAY ON TEST | 3| 3| 6| 4| 1| 3| 3| 3| 6| 6| 3| 3| 3| 3| 7| 3| 3| 8| 6| 0| 3| 0| 4| 1| 9| |
| 2| 2| 4| 7| 6| 3| 3| 3| 0| 0| 4| 4| 4| 3| 2| 4| 4| 2| 6| 3| 4| 0| 7| 2| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
.08 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + +| 17 |
Inguinal, Infiltration Cellular, | | |
Plasma Cell | | 1 3.0|
Mediastinal, Congestion | | 1 2.0|
Mediastinal, Pigmentation | 3 | 1 3.0|
Pancreatic, Hemorrhage | 2 | 1 2.0|
Renal, Congestion | | 1 3.0|
Renal, Pigmentation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M + + +| 10 |
Congestion | 2 | 2 2.0|
Infiltration Cellular, Plasma Cell | 4 4 | 3 3.7|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + +| 12 |
Pigmentation, Hemosiderin | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + +| 23 |
Hematopoietic Cell Proliferation | 4 2 2 2| 5 2.8|
Necrosis, Focal | 4 | 1 4.0|
Pigmentation, Hemosiderin | 3 2 2 2 | 6 2.3|
__________________________________________________________________________|____________|
Thymus | + + + + + M +| 11 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M + + + + + + + + + + + + +| 28 |
Galactocele | X X X X X X X X | 16 |
__________________________________________________________________________|____________|
Skin | + + + + + + +| 12 |
Subcutaneous Tissue, Abscess | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + +| 10 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + +| 10 |
Hemorrhage | 4 | 1 4.0|
Hydrocephalus | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + +| 29 |
Congestion | 2 2 2 2 | 14 1.9|
Granuloma | | 1 4.0|
Hemorrhage, Focal | 2 3 2 | 3 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05028-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROETHANE Date: 05/05/97
Route: GAVAGE Time: 08:33:49
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 5| 5| 5| 7| 7| 6| 6| 5| |
DAY ON TEST | 3| 3| 6| 4| 1| 3| 3| 3| 6| 6| 3| 3| 3| 3| 7| 3| 3| 8| 6| 0| 3| 0| 4| 1| 9| |
| 2| 2| 4| 7| 6| 3| 3| 3| 0| 0| 4| 4| 4| 3| 2| 4| 4| 2| 6| 3| 4| 0| 7| 2| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
.08 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Infiltration Cellular, Histiocyte | | 1 4.0|
Alveolar Epithelium, Metaplasia | | 1 3.0|
Alveolus, Atypia Cellular | 2 | 1 2.0|
Peribronchial, Inflammation, Chronic | 2 2 2 2| 10 2.0|
__________________________________________________________________________|____________|
Nose | + + + + +| 9 |
Inflammation, Chronic | 2 1 1| 3 1.3|
Metaplasia, Squamous | | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + +| 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + | 6 |
Lens, Mineralization, Focal | 2 | 2 2.0|
Posterior Chamber, Hemorrhage | | 1 3.0|
Retina, Degeneration | | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | + + | 3 |
Inflammation, Chronic, Focal | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 | 1 2.0|
Mineralization | 1 1 1 1 1 1 1 | 22 1.0|
Nephropathy | 2 1 2 2 2 2 2 1 2 2 1 2 3 2 1 1 2 2 1| 42 1.6|
Renal Tubule, Hyperplasia | | 1 1.0|
Renal Tubule, Pigmentation | 2 | 2 1.5|
Renal Tubule, Regeneration | 1 | 2 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + +| 11 |
Hyperplasia | 4 | 1 4.0|
Inflammation, Chronic | 3 2| 2 2.5|
Transitional Epithelium, Hyperplasia,| | |
Squamous | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 05028-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROETHANE Date: 05/05/97
Route: GAVAGE Time: 08:33:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 6| 6| 5| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 0| 2| 3| 3| 2| 8| 7| 3| 3| 3| 3| 5| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3|
| 4| 4| 4| 6| 6| 5| 0| 8| 1| 5| 6| 6| 6| 0| 0| 6| 6| 6| 6| 2| 6| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
.16 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + M M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + A + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 4 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + A + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 2 4 3 2 4 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + A + + M + + + + + + + + + + + + + +|
Parasite Metazoan | 4 4 2 4 3 3|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X 2 X X X X X X X X X|
Fatty Change | 3 2 1 2 1 2 3 2 1 3|
Granuloma | 2 3 |
Hepatodiaphragmatic Nodule | X X |
Necrosis, Focal | 1 1 1 1 2 3 2 1 3|
Bile Duct, Hyperplasia | 1 3 2 2 2 2 1 2 2|
Periductular, Inflammation, Chronic | |
__________________________________________________________________________|
Mesentery | +|
Granuloma | |
Fat, Necrosis | 4|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + I + +|
Acinus, Atrophy | 2 4 |
Acinus, Hyperplasia, Focal | 4 3 |
Artery, Inflammation | 4 |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Thrombosis | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 |
Hyperkeratosis | |
Inflammation, Chronic Active | 4 |
Mineralization, Focal | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 |
Inflammation, Chronic, Focal | 2 |
Mineralization, Focal | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05028-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROETHANE Date: 05/05/97
Route: GAVAGE Time: 08:33:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 6| 6| 5| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 0| 2| 3| 3| 2| 8| 7| 3| 3| 3| 3| 5| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3|
| 4| 4| 4| 6| 6| 5| 0| 8| 1| 5| 6| 6| 6| 0| 0| 6| 6| 6| 6| 2| 6| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
.16 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Cardiomyopathy | 1 2 3 2 2 2 2 3 1 2 2 1 3 2 1 2 |
Artery, Inflammation, Chronic, Focal | 4 |
Atrium Right, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Cytoplasmic Alteration, Focal | 3 3 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + M + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 3 1 3 2 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + M M + + M + + + + + M + + + + + M + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 4 4 4 |
Pars Distalis, Cyst | X X X X X X 3 X X X|
Pars Distalis, Hyperplasia, Focal | 3 3 3 2 |
Pars Intermedia, Angiectasis | 4 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | 4 |
C-Cell, Hyperplasia | 4 4 2 4 2 |
Follicle, Cyst | X |
Follicle, Hyperplasia, Focal | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + M + + + + + + + M M + + M M M + + M + + + + + +|
Abscess | 4 |
Dilatation | |
Hemorrhage | |
Hypertrophy | |
Inflammation, Acute | 1 |
Inflammation, Chronic | 1 2|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Cyst | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Dilatation | 3 3 4 3|
Inflammation, Chronic | 4 |
Thrombosis | X X |
Endometrium, Cyst | X |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05028-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROETHANE Date: 05/05/97
Route: GAVAGE Time: 08:33:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 6| 6| 5| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 0| 2| 3| 3| 2| 8| 7| 3| 3| 3| 3| 5| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3|
| 4| 4| 4| 6| 6| 5| 0| 8| 1| 5| 6| 6| 6| 0| 0| 6| 6| 6| 6| 2| 6| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
.16 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Endometrium, Hyperplasia | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + A + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 4 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Congestion | |
Pancreatic, Angiectasis | |
Pancreatic, Congestion | 2|
Renal, Congestion | 2 2 |
Renal, Granuloma | 4|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + M + + + + + + + + + + + M + + + +|
Angiectasis | 2 4 |
Infiltration Cellular, Plasma Cell | 4 2 3 2 3 2 4 3 4 3 2 3 3 4 2 3 3|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Granuloma | |
Hyperplasia, Lymphoid | 2 |
Pigmentation, Hemosiderin | 3 |
Pigmentation | 2|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hematopoietic Cell Proliferation | 2 2 3 2 2 2 2 2|
Pigmentation, Hemosiderin | 2 |
__________________________________________________________________________|
Thymus | I M M M + I + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
Ectasia | 2 4 2|
Galactocele | X 3 X X X X|
Inflammation, Focal, Subacute | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + M + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Hyperostosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | |
Hydrocephalus | 3 |
Infarct | 2 |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + M + + + +|
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05028-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROETHANE Date: 05/05/97
Route: GAVAGE Time: 08:33:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 6| 6| 5| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 0| 2| 3| 3| 2| 8| 7| 3| 3| 3| 3| 5| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3|
| 4| 4| 4| 6| 6| 5| 0| 8| 1| 5| 6| 6| 6| 0| 0| 6| 6| 6| 6| 2| 6| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
.16 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + +|
Degeneration | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 2 |
Granuloma | 2 2 |
Hemorrhage, Focal | 3 |
Alveolar Epithelium, Metaplasia | 2 3 2 |
Artery, Thrombosis | X |
Peribronchial, Inflammation, Chronic | 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 2 3 2 2 2 2 1 1 2 3 3 2 3|
Metaplasia, Squamous | 3 2 2 2 2 3 2 2 2 2 3 2 2 2 2 3 2 2 2 2 3|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | |
Retinal Detachment | 4 |
Cornea, Inflammation, Acute | |
Vitreous, Degeneration | 4 |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Casts | 1 |
Inflammation, Chronic | |
Mineralization | 1 1 2 1 2 2 1 2|
Nephropathy | 2 2 2 1 2 2 2 2 1 2 2 2 1 2 3 3 1 2 2 3 2|
Renal Tubule, Cyst | X X |
Renal Tubule, Pigmentation | 2 1 |
Renal Tubule, Regeneration | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + A + + + + + + + + + + + + + + + M +|
Transitional Epithelium, Hyperplasia | |
Wall, Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05028-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROETHANE Date: 05/05/97
Route: GAVAGE Time: 08:33:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4| |
DAY ON TEST | 3| 3| 3| 4| 0| 3| 3| 3| 3| 2| 3| 3| 3| 8| 6| 3| 3| 1| 4| 8| 3| 3| 3| 3| 6| |
| 6| 6| 8| 3| 6| 6| 6| 6| 6| 7| 6| 6| 8| 8| 5| 6| 6| 5| 5| 1| 6| 6| 6| 6| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
.16 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + + + + + + + +| 48 |
Parasite Metazoan | 4 2 2 2 | 5 2.8|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + A + + + + + + + + + + + + + + + + + + + +| 48 |
Parasite Metazoan | 2 | 7 2.7|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + A + + + + + + + + + + + + + + + + + + + +| 47 |
Parasite Metazoan | 2 4 4 X 2 2 | 12 3.1|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X | 28 2.0|
Fatty Change | 2 2 1 1 1 1 3 3 1 1| 20 1.8|
Granuloma | 1 3 2 | 5 2.2|
Hepatodiaphragmatic Nodule | X X | 4 |
Necrosis, Focal | 2 1 2 1 1 | 14 1.6|
Bile Duct, Hyperplasia | 1 2 2 2 1 2 1 2 3 2 2 2| 21 1.9|
Periductular, Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + | 5 |
Granuloma | 2 | 1 2.0|
Fat, Necrosis | 4 4 4 4 | 5 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acinus, Atrophy | 3 2 2 | 5 2.6|
Acinus, Hyperplasia, Focal | | 2 3.5|
Artery, Inflammation | | 1 4.0|
__________________________________________________________________________|____________|
Pharynx | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lumen, Thrombosis | X | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 2 3 | 3 2.7|
Hyperkeratosis | 3 | 1 3.0|
Inflammation, Chronic Active | 2 | 2 3.0|
Mineralization, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05028-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROETHANE Date: 05/05/97
Route: GAVAGE Time: 08:33:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4| |
DAY ON TEST | 3| 3| 3| 4| 0| 3| 3| 3| 3| 2| 3| 3| 3| 8| 6| 3| 3| 1| 4| 8| 3| 3| 3| 3| 6| |
| 6| 6| 8| 3| 6| 6| 6| 6| 6| 7| 6| 6| 8| 8| 5| 6| 6| 5| 5| 1| 6| 6| 6| 6| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
.16 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Chronic, Focal | | 1 2.0|
Mineralization, Focal | 2 3| 2 2.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 3 2 2 1 3 2 2 2 2 2| 27 2.0|
Artery, Inflammation, Chronic, Focal | | 1 4.0|
Atrium Right, Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | X | 1 |
Cytoplasmic Alteration, Focal | 2 2 | 5 2.4|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + M + + + + + + + + + I + M + + + + + + + + + +| 46 |
Hyperplasia, Focal | 3 3 | 7 2.4|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + M + + I + + + + + M + + + + + M + M + + M| 38 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Angiectasis | 3 2 4 | 7 3.4|
Pars Distalis, Cyst | X X X X X X X X X X X X X| 23 3.0|
Pars Distalis, Hyperplasia, Focal | 2 2 3 3 | 8 2.6|
Pars Intermedia, Angiectasis | 4 4 | 3 4.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ultimobranchial Cyst | X | 2 4.0|
C-Cell, Hyperplasia | 3 1 4 3 4 4 2 | 12 3.1|
Follicle, Cyst | X | 2 |
Follicle, Hyperplasia, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + M + + + + + M + + + + + M + M + + +| 39 |
Abscess | | 1 4.0|
Dilatation | 3 | 1 3.0|
Hemorrhage | 4 | 1 4.0|
Hypertrophy | 3 | 1 3.0|
Inflammation, Acute | 2 2 | 3 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05028-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROETHANE Date: 05/05/97
Route: GAVAGE Time: 08:33:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4| |
DAY ON TEST | 3| 3| 3| 4| 0| 3| 3| 3| 3| 2| 3| 3| 3| 8| 6| 3| 3| 1| 4| 8| 3| 3| 3| 3| 6| |
| 6| 6| 8| 3| 6| 6| 6| 6| 6| 7| 6| 6| 8| 8| 5| 6| 6| 5| 5| 1| 6| 6| 6| 6| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
.16 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Chronic | 2 1 | 4 1.5|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 2 | 2 2.0|
Cyst | X X | 4 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess | 4 | 1 4.0|
Dilatation | | 4 3.3|
Inflammation, Chronic | | 1 4.0|
Thrombosis | | 2 |
Endometrium, Cyst | | 1 |
Endometrium, Hyperplasia | 4 | 2 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 3 | 4 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mediastinal, Congestion | 2 | 1 2.0|
Pancreatic, Angiectasis | 4 | 1 4.0|
Pancreatic, Congestion | | 1 2.0|
Renal, Congestion | | 2 2.0|
Renal, Granuloma | 3 | 2 3.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + M + + + + M + + M + + + + M + + I + +| 43 |
Angiectasis | | 2 3.0|
Infiltration Cellular, Plasma Cell | 3 4 4 4 3 2 3 3 3 3 3 3 | 29 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + M + + + + + + + + + + +| 49 |
Congestion | 3 | 2 2.5|
Granuloma | 2 2 | 2 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
Pigmentation, Hemosiderin | | 1 3.0|
Pigmentation | 3 | 2 2.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 | 2 2.0|
Hematopoietic Cell Proliferation | 2 2 4 2 3 2 2 2 2 2| 18 2.2|
Pigmentation, Hemosiderin | 3 2| 3 2.3|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + M + + + + + + + + M + + + + + + + + + + M| 46 |
Ectasia | 3 4 3 3 | 7 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05028-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROETHANE Date: 05/05/97
Route: GAVAGE Time: 08:33:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4| |
DAY ON TEST | 3| 3| 3| 4| 0| 3| 3| 3| 3| 2| 3| 3| 3| 8| 6| 3| 3| 1| 4| 8| 3| 3| 3| 3| 6| |
| 6| 6| 8| 3| 6| 6| 6| 6| 6| 7| 6| 6| 8| 8| 5| 6| 6| 5| 5| 1| 6| 6| 6| 6| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
.16 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Galactocele | X X X 4 X X | 12 3.5|
Inflammation, Focal, Subacute | 4 | 1 4.0|
__________________________________________________________________________|____________|
Skin | + + M + + + + + + + + + + + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cranium, Hyperostosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 | 1 2.0|
Hemorrhage | 2 | 1 2.0|
Hydrocephalus | | 1 3.0|
Infarct | | 1 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + M M + + + M M + + M | 30 |
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + +| 38 |
Degeneration | 1| 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 1 | 4 2.0|
Granuloma | 2 | 3 2.0|
Hemorrhage, Focal | 2 3 | 3 2.7|
Alveolar Epithelium, Metaplasia | 2 | 4 2.3|
Artery, Thrombosis | | 1 |
Peribronchial, Inflammation, Chronic | 2 2 2 2 2 2 1 2 2 2 2 2 2 1 2 1 2| 32 1.9|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 3 2 3 2 2 1 | 20 2.2|
Metaplasia, Squamous | 2 2 3 2 2 3 2 2 2 2 2 3 2 2 2 2 2 3 2 3 | 41 2.2|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + +| 6 |
Cataract | 1 | 1 1.0|
Retinal Detachment | | 1 4.0|
Cornea, Inflammation, Acute | 4 | 1 4.0|
Vitreous, Degeneration | | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05028-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROETHANE Date: 05/05/97
Route: GAVAGE Time: 08:33:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4| |
DAY ON TEST | 3| 3| 3| 4| 0| 3| 3| 3| 3| 2| 3| 3| 3| 8| 6| 3| 3| 1| 4| 8| 3| 3| 3| 3| 6| |
| 6| 6| 8| 3| 6| 6| 6| 6| 6| 7| 6| 6| 8| 8| 5| 6| 6| 5| 5| 1| 6| 6| 6| 6| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
.16 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Casts | 4 | 2 2.5|
Inflammation, Chronic | 3 | 1 3.0|
Mineralization | 1 1 1 1 1 | 13 1.3|
Nephropathy | 1 3 3 1 1 3 1 3 2 2 2 2 2 4 2 1 2 2 1 1 1 2 3 2| 45 2.0|
Renal Tubule, Cyst | | 2 |
Renal Tubule, Pigmentation | 2 | 3 1.7|
Renal Tubule, Regeneration | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + A + + + + + + + + + + + + + + + + + + + +| 47 |
Transitional Epithelium, Hyperplasia | 4| 1 4.0|
Wall, Inflammation, Chronic Active | 3| 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05028-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROETHANE Date: 05/05/97
Route: GAVAGE Time: 08:33:49
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 1| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 5| 6| 3| 3| 3| 3| 3| 4| 4| 3| 3| 3| 1| 3| 3| 3| 3| 4| 3| 3| 3| 3| 8|
| 5| 5| 4| 6| 8| 5| 5| 5| 6| 6| 9| 5| 5| 5| 4| 5| 5| 5| 6| 6| 5| 5| 5| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Periesophageal Tissue, Inflammation, | |
Chronic Active | 3 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + A|
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 4 4 2 4 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 2 3 4 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + A|
Hyperplasia, Lymphoid | |
Parasite Metazoan | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | X 2 2 2 1 2 |
Congestion | 3 |
Cytoplasmic Alteration, Focal | |
Fatty Change | 1 3 3 3 1 1 2 2 3 2 2 3 1 |
Hepatodiaphragmatic Nodule | |
Hyperplasia | 2 |
Necrosis, Focal | 1 1 2 1 2 2 2 1 2 1 |
Bile Duct, Hyperplasia | 3 1 2 2 2 2 4 3 2 2 3 3 1 2 3 2 3 3 3 |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Acinus, Atrophy | 1 1 2 1 4 2 2 1 3 2 4 3 2 |
Acinus, Hyperplasia | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + M +|
Acanthosis | |
Hyperkeratosis | 3 2 2 |
Hyperplasia, Basal Cell | 3 |
Inflammation, Focal | |
Ulcer | 4 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05028-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROETHANE Date: 05/05/97
Route: GAVAGE Time: 08:33:49
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 1| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 5| 6| 3| 3| 3| 3| 3| 4| 4| 3| 3| 3| 1| 3| 3| 3| 3| 4| 3| 3| 3| 3| 8|
| 5| 5| 4| 6| 8| 5| 5| 5| 6| 6| 9| 5| 5| 5| 4| 5| 5| 5| 6| 6| 5| 5| 5| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 2 2 2 3 2 3 3 3 4 2 2 3 3 4 3 2 2 2 2|
Inflammation, Chronic | |
Mineralization | 3 |
Pigmentation, Hemosiderin | |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Cytoplasmic Alteration, Focal | 4 2 3 2 |
Hyperplasia, Focal | 2 2 |
Vacuolization Cytoplasmic | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 3 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + M + + + M + + + + + + + + + M|
Cyst | X |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | |
Pars Distalis, Hemorrhage | |
Pars Distalis, Hyperplasia, Focal | 3 2 3 4 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 3 2 2 2 3 2 2 |
Follicle, Cyst | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
Atrophy | |
Ectasia | 4 3 |
Hyperplasia | |
Inflammation, Acute | 4 |
Inflammation, Chronic | 1 2 2 2 2 1 2 2 2 3 2 3 2 3 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 4 2 |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05028-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROETHANE Date: 05/05/97
Route: GAVAGE Time: 08:33:49
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 1| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 5| 6| 3| 3| 3| 3| 3| 4| 4| 3| 3| 3| 1| 3| 3| 3| 3| 4| 3| 3| 3| 3| 8|
| 5| 5| 4| 6| 8| 5| 5| 5| 6| 6| 9| 5| 5| 5| 4| 5| 5| 5| 6| 6| 5| 5| 5| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Acute | |
Inflammation, Chronic | 2 2 1 2 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 4 4 3 3 3 3 3 4 4 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Seminiferous Tubule, Atrophy | 3 3 3 4 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Angiectasis | |
Lumbar, Infiltration Cellular, | |
Plasma Cell | 3 |
Lumbar, Infiltration Cellular, | |
Histiocyte | |
Mediastinal, Congestion | 2 1 |
Pancreatic, Congestion | 1 |
Renal, Congestion | |
Renal, Infiltration Cellular, | |
Histiocyte | 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + M + + + + + + + +|
Angiectasis | 4 |
Congestion | |
Infiltration Cellular, Plasma Cell | 3 3 3 3 3 3 3 4 3 3 3 3 3 3 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 4 |
Infiltration Cellular, Histiocyte | |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Fibrosis, Focal | 2 |
Hematopoietic Cell Proliferation | 3 3 3 |
Necrosis | 4 |
Pigmentation, Hemosiderin | 3 3 |
__________________________________________________________________________|
Thymus | M + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M + + M + + M + M M M + + + M M + + + + M|
Ectasia | 3 |
Galactocele | X |
Hyperplasia, Glandular | |
__________________________________________________________________________|
Skin | + + + + M + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05028-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROETHANE Date: 05/05/97
Route: GAVAGE Time: 08:33:49
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 1| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 5| 6| 3| 3| 3| 3| 3| 4| 4| 3| 3| 3| 1| 3| 3| 3| 3| 4| 3| 3| 3| 3| 8|
| 5| 5| 4| 6| 8| 5| 5| 5| 6| 6| 9| 5| 5| 5| 4| 5| 5| 5| 6| 6| 5| 5| 5| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Tarsal, Hyperostosis | |
__________________________________________________________________________|
Skeletal Muscle | + |
Back, Hemorrhage, Focal | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | 4|
Hydrocephalus | 3 2 2 2 2 |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Embolus | |
Fungus | |
Granuloma | |
Alveolar Epithelium, Hyperplasia, | |
Adenomatous | 2 |
Peribronchial, Inflammation, Chronic | 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 3 |
Fungus | 4 3 |
Inflammation, Chronic | 3 2 2 2 3 2 3 1 3 2 2 4 2 2 2 1 2 3 |
Inflammation, Chronic Active | 3 |
Metaplasia, Squamous | 3 2 2 2 2 3 1 3 4 3 4 2 3 3 3 2 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Inflammation, Chronic, Focal | 2 |
__________________________________________________________________________|
Eye | + +|
Cataract | 2 |
Retina, Degeneration | |
Sclera, Mineralization, Focal | |
__________________________________________________________________________|
Zymbal's Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 1 |
Mineralization | 1 |
Nephropathy | 2 2 4 4 4 2 2 2 2 1 4 3 2 3 2 2 2 3 2 2 3 2 2 3|
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05028-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROETHANE Date: 05/05/97
Route: GAVAGE Time: 08:33:49
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 1| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 5| 6| 3| 3| 3| 3| 3| 4| 4| 3| 3| 3| 1| 3| 3| 3| 3| 4| 3| 3| 3| 3| 8|
| 5| 5| 4| 6| 8| 5| 5| 5| 6| 6| 9| 5| 5| 5| 4| 5| 5| 5| 6| 6| 5| 5| 5| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Cyst | X X |
Renal Tubule, Hyperplasia | 2 1 |
Renal Tubule, Pigmentation | |
Renal Tubule, Regeneration | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + A + + + M + + + + + + + + + +|
Concretion | 4 4 4 |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05028-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROETHANE Date: 05/05/97
Route: GAVAGE Time: 08:33:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 5| 5| 4| 6| 7| 7| 6| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 3| |
DAY ON TEST | 3| 3| 3| 3| 6| 3| 3| 6| 3| 0| 3| 3| 3| 8| 2| 3| 3| 3| 3| 8| 3| 3| 3| 2| 5| |
| 5| 5| 5| 5| 7| 5| 5| 8| 0| 6| 7| 5| 5| 7| 6| 6| 6| 6| 0| 9| 6| 6| 5| 0| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Periesophageal Tissue, Inflammation, | | |
Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | 2 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | 4 3 3 4 | 10 3.2|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | 2 4 2 3 4 2| 10 2.8|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
Parasite Metazoan | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 2.0|
Basophilic Focus | 1 2 2 1 1 | 11 1.6|
Congestion | | 1 3.0|
Cytoplasmic Alteration, Focal | 2 2 | 2 2.0|
Fatty Change | 2 2 2 2 2 2 1 2 1 2 1 1 3 3| 27 2.0|
Hepatodiaphragmatic Nodule | X | 1 |
Hyperplasia | | 1 2.0|
Necrosis, Focal | 1 2 1 1 1 1 1 2 1 1 | 20 1.4|
Bile Duct, Hyperplasia | 2 2 3 4 2 2 2 3 2 2 4 3 1 2 3 2 2 3 2 2 2 | 40 2.4|
__________________________________________________________________________|____________|
Mesentery | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 | 1 2.0|
Acinus, Atrophy | 3 3 2 3 2 3 4 2 2 3 | 23 2.4|
Acinus, Hyperplasia | 3 4 4 3 | 5 3.6|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + M + + + + + + + + + + + + + + + + + + + + +| 48 |
Acanthosis | 3 | 1 3.0|
Hyperkeratosis | 3 | 4 2.5|
Hyperplasia, Basal Cell | | 1 3.0|
Inflammation, Focal | 2 2 | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05028-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROETHANE Date: 05/05/97
Route: GAVAGE Time: 08:33:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 5| 5| 4| 6| 7| 7| 6| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 3| |
DAY ON TEST | 3| 3| 3| 3| 6| 3| 3| 6| 3| 0| 3| 3| 3| 8| 2| 3| 3| 3| 3| 8| 3| 3| 3| 2| 5| |
| 5| 5| 5| 5| 7| 5| 5| 8| 0| 6| 7| 5| 5| 7| 6| 6| 6| 6| 0| 9| 6| 6| 5| 0| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Ulcer | | 2 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 3 3 2 3 2 3 2 4 3 2 3 2 2 3 2 1 4| 37 2.6|
Inflammation, Chronic | 3| 1 3.0|
Mineralization | | 1 3.0|
Pigmentation, Hemosiderin | 2| 1 2.0|
Atrium, Thrombosis | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | X | 1 |
Cytoplasmic Alteration, Focal | 2 2 | 6 2.5|
Hyperplasia, Focal | 2 | 3 2.0|
Vacuolization Cytoplasmic | 2 | 2 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 3 3 3 2 | 6 2.8|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 3 | 4 2.5|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + M M M + + + M + + + + + + + + + + M| 41 |
Cyst | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Angiectasis | 3 2 | 2 2.5|
Pars Distalis, Cyst | X | 1 |
Pars Distalis, Hemorrhage | 4| 1 4.0|
Pars Distalis, Hyperplasia, Focal | 3 3 2 2 3 3 | 11 2.7|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
C-Cell, Hyperplasia | 2 2 | 10 2.2|
Follicle, Cyst | X | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + M| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05028-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROETHANE Date: 05/05/97
Route: GAVAGE Time: 08:33:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 5| 5| 4| 6| 7| 7| 6| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 3| |
DAY ON TEST | 3| 3| 3| 3| 6| 3| 3| 6| 3| 0| 3| 3| 3| 8| 2| 3| 3| 3| 3| 8| 3| 3| 3| 2| 5| |
| 5| 5| 5| 5| 7| 5| 5| 8| 0| 6| 7| 5| 5| 7| 6| 6| 6| 6| 0| 9| 6| 6| 5| 0| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Atrophy | 2 | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + M M + + + + + + + + + + + + + + + + + M +| 46 |
Atrophy | 4 | 1 4.0|
Ectasia | | 2 3.5|
Hyperplasia | 3 | 1 3.0|
Inflammation, Acute | | 1 4.0|
Inflammation, Chronic | 3 2 2 2 3 2 1 2 4 3 1 1 2 1 2| 29 2.1|
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | | 2 3.0|
Inflammation, Acute | 2 3 3| 3 2.7|
Inflammation, Chronic | 2 1 2 | 8 1.6|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 3 3 4 4 4 4 4 4 2 3 4 4 3 3 | 27 3.4|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + M| 49 |
Seminiferous Tubule, Atrophy | 4 2 4 | 8 3.4|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inguinal, Angiectasis | 4 | 1 4.0|
Lumbar, Infiltration Cellular, | | |
Plasma Cell | | 1 3.0|
Lumbar, Infiltration Cellular, | | |
Histiocyte | 4 | 1 4.0|
Mediastinal, Congestion | 3 | 3 2.0|
Pancreatic, Congestion | | 1 1.0|
Renal, Congestion | 3 | 1 3.0|
Renal, Infiltration Cellular, | | |
Histiocyte | 4 | 2 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + M + + + + + + + + M + + M + + + + M| 45 |
Angiectasis | 4 3 | 3 3.7|
Congestion | 3 2 | 2 2.5|
Infiltration Cellular, Plasma Cell | 4 3 2 3 2 3 3 2 3 4 3 | 26 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 2 3.0|
Infiltration Cellular, Histiocyte | 2 | 1 2.0|
Pigmentation, Hemosiderin | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05028-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROETHANE Date: 05/05/97
Route: GAVAGE Time: 08:33:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 5| 5| 4| 6| 7| 7| 6| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 3| |
DAY ON TEST | 3| 3| 3| 3| 6| 3| 3| 6| 3| 0| 3| 3| 3| 8| 2| 3| 3| 3| 3| 8| 3| 3| 3| 2| 5| |
| 5| 5| 5| 5| 7| 5| 5| 8| 0| 6| 7| 5| 5| 7| 6| 6| 6| 6| 0| 9| 6| 6| 5| 0| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 |
Congestion | 2 | 1 2.0|
Fibrosis, Focal | 2 2 | 3 2.0|
Hematopoietic Cell Proliferation | 2 4 3 | 6 3.0|
Necrosis | | 1 4.0|
Pigmentation, Hemosiderin | 2 3| 4 2.8|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + M + M + + + + + + + + + +| 47 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + M + + M M + + + + + + M M + M M + + + M| 33 |
Ectasia | | 1 3.0|
Galactocele | | 1 |
Hyperplasia, Glandular | 4 | 1 4.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + M + + + + +| 48 |
Cyst Epithelial Inclusion | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Tarsal, Hyperostosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + + + | 4 |
Back, Hemorrhage, Focal | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage, Focal | 2 2 4| 4 3.0|
Hydrocephalus | | 5 2.2|
__________________________________________________________________________|____________|
Spinal Cord | I | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3| 2 3.0|
Embolus | 3 | 1 3.0|
Fungus | X | 1 |
Granuloma | 4 | 1 4.0|
Alveolar Epithelium, Hyperplasia, | | |
Adenomatous | | 1 2.0|
Peribronchial, Inflammation, Chronic | 2 2 2 2 2 2 2 2 2 2 2 1 2 2 | 34 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05028-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROETHANE Date: 05/05/97
Route: GAVAGE Time: 08:33:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 5| 5| 4| 6| 7| 7| 6| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 3| |
DAY ON TEST | 3| 3| 3| 3| 6| 3| 3| 6| 3| 0| 3| 3| 3| 8| 2| 3| 3| 3| 3| 8| 3| 3| 3| 2| 5| |
| 5| 5| 5| 5| 7| 5| 5| 8| 0| 6| 7| 5| 5| 7| 6| 6| 6| 6| 0| 9| 6| 6| 5| 0| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Fungus | X | 3 3.5|
Inflammation, Chronic | 2 2 2 1 2 3 2 2 2 2 2 2 3 4 4 3 3 2 | 36 2.3|
Inflammation, Chronic Active | | 1 3.0|
Metaplasia, Squamous | 2 2 2 2 2 2 2 2 2 1 3 3 2 4 4 2 3 | 34 2.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
Inflammation, Chronic, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Eye | + + + | 5 |
Cataract | 2 4 | 3 2.7|
Retina, Degeneration | 4 | 1 4.0|
Sclera, Mineralization, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3| 2 2.0|
Mineralization | 2 | 2 1.5|
Nephropathy | 1 3 1 2 2 3 4 2 2 2 4 3 4 2 2 1 2 2 3 3 2 3 2 2 | 48 2.4|
Renal Tubule, Cyst | | 2 |
Renal Tubule, Hyperplasia | | 2 1.5|
Renal Tubule, Pigmentation | 3 | 1 3.0|
Renal Tubule, Regeneration | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + A| 47 |
Concretion | 4 | 4 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05028-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROETHANE Date: 05/05/97
Route: GAVAGE Time: 08:33:49
_____________________________________________________________________________________________________________________
| 7| 6| 6| 5| 3| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 1| 0| 7| 7| 3| 3| 2| 0| 4| 3| 3| 3| 2| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1|
| 5| 4| 2| 8| 0| 4| 4| 3| 5| 4| 4| 4| 4| 5| 9| 5| 5| 5| 5| 9| 5| 5| 5| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
.01 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + M + + +|
Foreign Body | |
Perforation | |
Periesophageal Tissue, Inflammation, | |
Acute | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + A + + + A + + +|
Parasite Metazoan | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + M + + + + +|
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | M + + + + + + + +|
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 1 1 1 1 1 2 1|
Congestion | 4 |
Cytoplasmic Alteration, Focal | 2 2 |
Fatty Change | 1 1 1 3 2 2 2 2 2|
Hepatodiaphragmatic Nodule | 3 |
Hyperplasia, Focal | |
Necrosis, Focal | 1 3 |
Bile Duct, Hyperplasia | 1 2 2 1 2 2 3 4 3 2 2 2 3 2 2|
Centrilobular, Necrosis, Focal | 2 |
Serosa, Proliferation | 2 |
__________________________________________________________________________|
Mesentery | + + + +|
Fat, Necrosis | 3 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + +|
Acinus, Atrophy | 3 2 3 |
Duct, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + +|
Acanthosis | 4 2 2 |
Hyperkeratosis | 3 3 2 |
Hyperplasia, Basal Cell | 1 |
Ulcer | 3 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Tongue | +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05028-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROETHANE Date: 05/05/97
Route: GAVAGE Time: 08:33:49
_____________________________________________________________________________________________________________________
| 7| 6| 6| 5| 3| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 1| 0| 7| 7| 3| 3| 2| 0| 4| 3| 3| 3| 2| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1|
| 5| 4| 2| 8| 0| 4| 4| 3| 5| 4| 4| 4| 4| 5| 9| 5| 5| 5| 5| 9| 5| 5| 5| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
.01 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + +|
Cardiomyopathy | 3 3 3 3 2 3 4 4 4 3|
Hemorrhage, Focal | |
Inflammation, Chronic | 3 |
Pigmentation, Hemosiderin | 2 |
Atrium, Dilatation | 4 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration, Focal | 2 |
Hyperplasia, Focal | 1 2 2|
Vacuolization Cytoplasmic | 2 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + M + + + + + + + + + I + + + + +|
Hyperplasia, Focal | 2 2 2 3 |
Thrombosis | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M M M + + + + + + + + + M + + + + M + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X |
Pars Distalis, Hemorrhage | 3 |
Pars Distalis, Hyperplasia, Focal | 2 2 2 1 |
Pars Distalis, Pigmentation, | |
Hemosiderin | |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 1 1 |
Follicle, Cyst | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + +|
Abscess | 3 |
Inflammation, Chronic | 2 3 2|
__________________________________________________________________________|
Prostate | + + + + + + + + +|
Abscess | |
Inflammation, Acute | 2 4 |
Inflammation, Chronic | 2 2 2|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + +|
Atrophy | 3 3 2 3 4 2 4 |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05028-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROETHANE Date: 05/05/97
Route: GAVAGE Time: 08:33:49
_____________________________________________________________________________________________________________________
| 7| 6| 6| 5| 3| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 1| 0| 7| 7| 3| 3| 2| 0| 4| 3| 3| 3| 2| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1|
| 5| 4| 2| 8| 0| 4| 4| 3| 5| 4| 4| 4| 4| 5| 9| 5| 5| 5| 5| 9| 5| 5| 5| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
.01 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Dilatation | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Necrosis | 2|
Interstitial Cell, Hyperplasia | 2 |
Seminiferous Tubule, Atrophy | 4 2 4|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + +|
Hyperplasia | 2|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + +|
Axillary, Congestion | |
Lumbar, Congestion | |
Mediastinal, Congestion | 3 3 3 2 |
Mediastinal, Infiltration Cellular, | |
Plasma Cell | 2 4 |
Pancreatic, Congestion | |
Renal, Congestion | |
Renal, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + +|
Congestion | 2 |
Infiltration Cellular, Plasma Cell | 3 4 4 3 3 3 3 4 3|
Lymphatic, Angiectasis | 4 3 3|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + +|
Congestion | 3|
Infiltration Cellular, Plasma Cell | |
Necrosis | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + +|
Congestion | |
Fibrosis, Focal | |
Fibrosis | 2 4 |
Hematopoietic Cell Proliferation | 3 2 2 4|
Pigmentation, Hemosiderin | 2 2 2 3 |
__________________________________________________________________________|
Thymus | + + + + M + + + |
Congestion | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M M + + + + + + + + +|
Galactocele | X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + +|
Subcutaneous Tissue, Necrosis | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05028-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROETHANE Date: 05/05/97
Route: GAVAGE Time: 08:33:49
_____________________________________________________________________________________________________________________
| 7| 6| 6| 5| 3| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 1| 0| 7| 7| 3| 3| 2| 0| 4| 3| 3| 3| 2| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1|
| 5| 4| 2| 8| 0| 4| 4| 3| 5| 4| 4| 4| 4| 5| 9| 5| 5| 5| 5| 9| 5| 5| 5| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
.01 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Skeletal Muscle | M |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + +|
Hemorrhage, Focal | 1 |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + +|
Congestion | 2 4 2 4 |
Edema | 2 |
Foreign Body | |
Granuloma | 3 |
Hemorrhage, Focal | 3 2 |
Infiltration Cellular, Histiocyte | |
Alveolar Epithelium, Metaplasia, | |
Focal | |
Peribronchial, Inflammation, Chronic | 2 2 2 2|
Pleura, Inflammation, Acute | |
__________________________________________________________________________|
Nose | + + + + + + + + +|
Fungus | 3 |
Hemorrhage, Focal | 2 |
Inflammation, Acute | 4 |
Inflammation, Chronic | 3 1 2 2 2 1|
Metaplasia, Squamous | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cataract | |
Retina, Degeneration | |
__________________________________________________________________________|
Harderian Gland | + |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | |
Hyperplasia | |
Mineralization | 1 2 2 1 |
Nephropathy | 4 4 2 4 1 4 2 2 4 3 3 3 2 3 2 2 2 2 2 2 3 4 2 3 2|
Artery, Inflammation, Chronic | |
Pelvis, Inflammation, Acute | 4 3 |
Pelvis, Transitional Epithelium, | |
Hyperplasia | 2 2 3 |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05028-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROETHANE Date: 05/05/97
Route: GAVAGE Time: 08:33:49
_____________________________________________________________________________________________________________________
| 7| 6| 6| 5| 3| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 1| 0| 7| 7| 3| 3| 2| 0| 4| 3| 3| 3| 2| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1|
| 5| 4| 2| 8| 0| 4| 4| 3| 5| 4| 4| 4| 4| 5| 9| 5| 5| 5| 5| 9| 5| 5| 5| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
.01 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Cyst | X |
Renal Tubule, Hyperplasia | 1 3|
Renal Tubule, Pigmentation | 2 3 3|
__________________________________________________________________________|
Urinary Bladder | + A + + + A + + +|
Concretion | |
Lumen, Thrombosis | X |
Transitional Epithelium, Hyperplasia | 3 |
Wall, Inflammation, Acute | 3 |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05028-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROETHANE Date: 05/05/97
Route: GAVAGE Time: 08:33:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 5| 7| 7| 7| 6| 6| |
DAY ON TEST | 3| 3| 3| 2| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 8| 6| 2| 9| 3| 3| 0| 7| 1| |
| 5| 5| 5| 3| 9| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 5| 4| 5| 3| 7| 5| 5| 8| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
.01 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + +| 13 |
Foreign Body | 3 | 1 3.0|
Perforation | X | 1 |
Periesophageal Tissue, Inflammation, | | |
Acute | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + +| 14 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + +| 12 |
Parasite Metazoan | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + +| 13 |
Parasite Metazoan | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + +| 12 |
Parasite Metazoan | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + +| 16 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + +| 15 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A + +| 14 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | M + + + +| 14 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + +| 31 |
Basophilic Focus | 2 1 2 | 10 1.3|
Congestion | 3 | 2 3.5|
Cytoplasmic Alteration, Focal | | 2 2.0|
Fatty Change | 2 2 2 2 3| 14 1.9|
Hepatodiaphragmatic Nodule | X X | 3 3.0|
Hyperplasia, Focal | 2 | 1 2.0|
Necrosis, Focal | 2 | 3 2.0|
Bile Duct, Hyperplasia | 2 4 2 2 2 3 2 1 3| 24 2.3|
Centrilobular, Necrosis, Focal | | 1 2.0|
Serosa, Proliferation | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 5 |
Fat, Necrosis | | 2 3.5|
__________________________________________________________________________|____________|
Pancreas | + + + + A +| 18 |
Acinus, Atrophy | | 3 2.7|
Duct, Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Pharynx | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + +| 13 |
__________________________________________________________________________|____________|
Stomach | + + + + + + +| 19 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + +| 18 |
Acanthosis | | 3 2.7|
Hyperkeratosis | | 3 2.7|
Hyperplasia, Basal Cell | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05028-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROETHANE Date: 05/05/97
Route: GAVAGE Time: 08:33:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 5| 7| 7| 7| 6| 6| |
DAY ON TEST | 3| 3| 3| 2| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 8| 6| 2| 9| 3| 3| 0| 7| 1| |
| 5| 5| 5| 3| 9| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 5| 4| 5| 3| 7| 5| 5| 8| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
.01 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Ulcer | 4 | 3 3.7|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + +| 19 |
Infiltration Cellular, Lymphocyte | 4 4 | 2 4.0|
__________________________________________________________________________|____________|
Tongue | + | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + +| 15 |
Cardiomyopathy | 3 2 3 4| 14 3.1|
Hemorrhage, Focal | 2 | 1 2.0|
Inflammation, Chronic | | 1 3.0|
Pigmentation, Hemosiderin | | 1 2.0|
Atrium, Dilatation | | 2 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cytoplasmic Alteration, Focal | | 1 2.0|
Hyperplasia, Focal | 1 2 | 5 1.6|
Vacuolization Cytoplasmic | 2 2 3 2 1 3| 8 2.3|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + I + + + + M + + + + + + + M + +| 45 |
Hyperplasia, Focal | | 4 2.3|
Thrombosis | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + A +| 17 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + M + + + + + + + + + M M M + + + + +| 40 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Cyst | | 1 |
Pars Distalis, Hemorrhage | | 1 3.0|
Pars Distalis, Hyperplasia, Focal | 2 1 3 4 3 1 4 2 3 | 13 2.3|
Pars Distalis, Pigmentation, | | |
Hemosiderin | 3 | 1 3.0|
Pars Intermedia, Cyst | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 4 2 4 3 2 1 | 10 2.2|
Follicle, Cyst | X X | 3 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05028-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROETHANE Date: 05/05/97
Route: GAVAGE Time: 08:33:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 5| 7| 7| 7| 6| 6| |
DAY ON TEST | 3| 3| 3| 2| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 8| 6| 2| 9| 3| 3| 0| 7| 1| |
| 5| 5| 5| 3| 9| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 5| 4| 5| 3| 7| 5| 5| 8| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
.01 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + +| 14 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + +| 17 |
Abscess | | 1 3.0|
Inflammation, Chronic | 3 2 3| 6 2.5|
__________________________________________________________________________|____________|
Prostate | + + + +| 13 |
Abscess | 3 | 1 3.0|
Inflammation, Acute | | 2 3.0|
Inflammation, Chronic | 1 2| 5 1.8|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + +| 23 |
Atrophy | 3 4 4 4 4 | 12 3.3|
Dilatation | 4 3 | 2 3.5|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Edema | 4 | 1 4.0|
Necrosis | | 1 2.0|
Interstitial Cell, Hyperplasia | 3 | 2 2.5|
Seminiferous Tubule, Atrophy | 4 | 4 3.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + +| 13 |
Hyperplasia | 3| 2 2.5|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + +| 31 |
Axillary, Congestion | 4 | 1 4.0|
Lumbar, Congestion | 2 | 1 2.0|
Mediastinal, Congestion | | 4 2.8|
Mediastinal, Infiltration Cellular, | | |
Plasma Cell | | 2 3.0|
Pancreatic, Congestion | 4 | 1 4.0|
Renal, Congestion | 4 2 | 2 3.0|
Renal, Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + +| 23 |
Congestion | 4 2 2 3 | 5 2.6|
Infiltration Cellular, Plasma Cell | 3 2 4 3 4 4 3| 16 3.3|
Lymphatic, Angiectasis | 4 | 4 3.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + +| 15 |
Congestion | 4 | 2 3.5|
Infiltration Cellular, Plasma Cell | 3| 1 3.0|
Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + +| 28 |
Congestion | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05028-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROETHANE Date: 05/05/97
Route: GAVAGE Time: 08:33:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 5| 7| 7| 7| 6| 6| |
DAY ON TEST | 3| 3| 3| 2| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 8| 6| 2| 9| 3| 3| 0| 7| 1| |
| 5| 5| 5| 3| 9| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 5| 4| 5| 3| 7| 5| 5| 8| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
.01 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Fibrosis, Focal | 4 | 1 4.0|
Fibrosis | 3 | 3 3.0|
Hematopoietic Cell Proliferation | | 4 2.8|
Pigmentation, Hemosiderin | 4 | 5 2.6|
__________________________________________________________________________|____________|
Thymus | M M + M + + +| 11 |
Congestion | 3 2 | 2 2.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + + M M + + +| 16 |
Galactocele | X X | 4 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + +| 21 |
Subcutaneous Tissue, Necrosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + +| 13 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + +| 13 |
Hemorrhage, Focal | 4 4 4 | 4 3.3|
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + +| 24 |
Congestion | 2 2 1 | 7 2.4|
Edema | | 1 2.0|
Foreign Body | 3 | 1 3.0|
Granuloma | | 1 3.0|
Hemorrhage, Focal | 2 2 | 4 2.3|
Infiltration Cellular, Histiocyte | 3 | 1 3.0|
Alveolar Epithelium, Metaplasia, | | |
Focal | 3 | 1 3.0|
Peribronchial, Inflammation, Chronic | 2 | 5 2.0|
Pleura, Inflammation, Acute | 4 | 1 4.0|
__________________________________________________________________________|____________|
Nose | + + + +| 13 |
Fungus | | 1 3.0|
Hemorrhage, Focal | | 1 2.0|
Inflammation, Acute | | 1 4.0|
Inflammation, Chronic | 3| 7 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05028-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROETHANE Date: 05/05/97
Route: GAVAGE Time: 08:33:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 5| 7| 7| 7| 6| 6| |
DAY ON TEST | 3| 3| 3| 2| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 8| 6| 2| 9| 3| 3| 0| 7| 1| |
| 5| 5| 5| 3| 9| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 5| 4| 5| 3| 7| 5| 5| 8| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
.01 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Metaplasia, Squamous | | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + +| 13 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + +| 3 |
Cataract | 3| 1 3.0|
Retina, Degeneration | 4 | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | +| 2 |
Inflammation, Chronic | 2| 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage, Focal | 2 | 1 2.0|
Hyperplasia | 1 | 1 1.0|
Mineralization | 1 2 1 2 1 2 2 2 2 1 1 | 15 1.5|
Nephropathy | 2 3 4 2 3 2 1 2 4 4 2 2 2 4 3 3 2 2 4 4 2 4 2| 48 2.7|
Artery, Inflammation, Chronic | 4 | 1 4.0|
Pelvis, Inflammation, Acute | | 2 3.5|
Pelvis, Transitional Epithelium, | | |
Hyperplasia | 3 3 1 2 | 7 2.3|
Renal Tubule, Cyst | X X | 3 |
Renal Tubule, Hyperplasia | 1 1 | 4 1.5|
Renal Tubule, Pigmentation | 2 | 4 2.5|
__________________________________________________________________________|____________|
Urinary Bladder | A + A + +| 10 |
Concretion | 4 | 1 4.0|
Lumen, Thrombosis | | 1 |
Transitional Epithelium, Hyperplasia | | 1 3.0|
Wall, Inflammation, Acute | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05028-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROETHANE Date: 05/05/97
Route: GAVAGE Time: 08:33:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 6| 5| 5| 7| 7| 7| 4| 3| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 3| 2| 0| 3| 3| 1| 8| 3| 3| 3| 3| 6| 5| 3| 3| 3| 4| 5|
| 3| 3| 3| 3| 3| 3| 3| 3| 4| 9| 3| 2| 3| 6| 4| 4| 4| 3| 7| 9| 3| 3| 3| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
.02 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + M + + A + + + + + + + M + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + A + + + + + + + + + + + +|
Parasite Metazoan | 2 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + A + + + + + + + + + + + +|
Parasite Metazoan | 3 2 2 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X 1 1 1 1 1 1 X X 1 X |
Cytoplasmic Alteration, Focal | 2 |
Fatty Change | 1 2 1 1 2 3 2 2 1 1 2 3|
Fibrosis, Focal | |
Hepatodiaphragmatic Nodule | X X |
Mineralization, Focal | |
Necrosis, Focal | 1 1 1 2 1 2 1 2 1 1 1 1 |
Bile Duct, Hyperplasia | 3 2 2 1 1 2 3 2 2 2 3 2 3 2 3 1 2 2 3 2|
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 3 3 2 |
Acinus, Hyperplasia | 3 |
Artery, Inflammation | |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Karyomegaly, Focal | 2 3 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Serosa, Fibrosis | 4 |
Serosa, Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 |
Cyst Epithelial Inclusion | X |
Hyperkeratosis | 4 |
Hyperplasia, Basal Cell | 1 |
Ulcer | 4 3 |
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Infiltration Cellular, Lymphocyte | 4 |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05028-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROETHANE Date: 05/05/97
Route: GAVAGE Time: 08:33:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 6| 5| 5| 7| 7| 7| 4| 3| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 3| 2| 0| 3| 3| 1| 8| 3| 3| 3| 3| 6| 5| 3| 3| 3| 4| 5|
| 3| 3| 3| 3| 3| 3| 3| 3| 4| 9| 3| 2| 3| 6| 4| 4| 4| 3| 7| 9| 3| 3| 3| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
.02 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic | |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 3 2 1 2 3 2 3 2 4 2 4 3 3 2 2 2 4 1 4|
Inflammation, Chronic | |
Atrium, Dilatation | |
Atrium, Thrombosis | 3 X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration, Focal | 2 |
Hyperplasia, Focal | 1 2 |
Hypertrophy | 1 |
Vacuolization Cytoplasmic | 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 3 4 3 2 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + M + M + + + + M + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia, Focal | 1 2 2 2 2 2|
Pars Distalis, Pigmentation, | |
Hemosiderin | |
Pars Distalis, Vacuolization | |
Cytoplasmic | |
Pars Intermedia, Cyst | X |
Pars Nervosa, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 3 1 3 3 2 1 4 |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Dilatation, Focal | 3 |
Inflammation, Chronic | |
__________________________________________________________________________|
Preputial Gland | + + + M + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05028-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROETHANE Date: 05/05/97
Route: GAVAGE Time: 08:33:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 6| 5| 5| 7| 7| 7| 4| 3| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 3| 2| 0| 3| 3| 1| 8| 3| 3| 3| 3| 6| 5| 3| 3| 3| 4| 5|
| 3| 3| 3| 3| 3| 3| 3| 3| 4| 9| 3| 2| 3| 6| 4| 4| 4| 3| 7| 9| 3| 3| 3| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
.02 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Abscess | 4 4 |
Ectasia | |
Inflammation, Acute | 2 4 2 |
Inflammation, Chronic | 2 2 2 2 1 2 1 2 3 |
Inflammation, Chronic Active | |
Inflammation, Granulomatous | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Hyperplasia, Focal | 3 3 2 3 3 |
Inflammation, Acute | |
Inflammation, Chronic | 3 2 2 2 2 |
Inflammation, Chronic Active | |
Metaplasia, Squamous | 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 3 4 4 3 4 4 4 3 2 2 4 2 4 4 4 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Seminiferous Tubule, Atrophy | 2 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + M + + + + + + + +|
Hyperplasia | 3 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumbar, Hyperplasia | 2 |
Mediastinal, Congestion | |
Mediastinal, Pigmentation, | |
Hemosiderin | 4 |
Pancreatic, Pigmentation, Hemosiderin| |
Renal, Pigmentation, Hemosiderin | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M + + M + + + + + + + + M + + + + +|
Angiectasis | |
Congestion | |
Infiltration Cellular, Plasma Cell | 4 3 3 3 3 3 3 4 3 2 4 3 4 3 4 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Cyst | X|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Depletion Lymphoid | |
Fibrosis, Focal | |
Hematopoietic Cell Proliferation | 2 2 2 2 2 3|
Pigmentation, Hemosiderin | 3 2 3 3 3 |
__________________________________________________________________________|
Thymus | + + M + + M + + + + + + + + + + + + M M + + + + +|
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05028-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROETHANE Date: 05/05/97
Route: GAVAGE Time: 08:33:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 6| 5| 5| 7| 7| 7| 4| 3| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 3| 2| 0| 3| 3| 1| 8| 3| 3| 3| 3| 6| 5| 3| 3| 3| 4| 5|
| 3| 3| 3| 3| 3| 3| 3| 3| 4| 9| 3| 2| 3| 6| 4| 4| 4| 3| 7| 9| 3| 3| 3| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
.02 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + M + + M + + M + + M M + + M + M M M M + +|
Hemorrhage | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Hyperkeratosis | |
Subcutaneous Tissue, Fibrosis | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | 2 |
Hydrocephalus | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Foreign Body | 3 |
Granuloma | 2 2 2 |
Alveolar Epithelium, Hyperplasia, | |
Adenomatous | 3 |
Alveolar Epithelium, Metaplasia, | |
Focal | 4 1 |
Artery, Ectasia | |
Peribronchial, Inflammation, Chronic | 2 2 1 2 2 2 2 1 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | X |
Inflammation, Acute | |
Inflammation, Chronic | 3 4 1 1 3 3 2 2 3 2 2 3 2 3 2 |
Metaplasia, Squamous | 3 3 2 3 3 3 2 3 2 2 2 2 3 3 3 4|
Lymphatic, Angiectasis | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | M |
Retina, Degeneration | |
Vitreous, Hemorrhage | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05028-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROETHANE Date: 05/05/97
Route: GAVAGE Time: 08:33:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 6| 5| 5| 7| 7| 7| 4| 3| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 3| 2| 0| 3| 3| 1| 8| 3| 3| 3| 3| 6| 5| 3| 3| 3| 4| 5|
| 3| 3| 3| 3| 3| 3| 3| 3| 4| 9| 3| 2| 3| 6| 4| 4| 4| 3| 7| 9| 3| 3| 3| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
.02 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Casts | 4 |
Cytomegaly | 1 1 |
Hyperplasia | |
Inflammation, Chronic | 2 |
Mineralization | 2 2 2 1 1 3 3 2 2 3 3 3 3 2 3 2 3|
Nephropathy | 4 4 3 4 2 4 2 3 4 4 4 2 2 4 1 3 4 3 1 3 2 2|
Pelvis, Transitional Epithelium, | |
Hyperplasia | 2 3 3 3 |
Renal Tubule, Cyst | X |
Renal Tubule, Hyperplasia | 2 1 2 3 |
Renal Tubule, Necrosis, Focal | |
Renal Tubule, Pigmentation | 4 2 1|
Renal Tubule, Regeneration | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + A + + + + M + + + + + + +|
Concretion | |
Transitional Epithelium, Hyperplasia | 3 |
Wall, Inflammation, Chronic Active | 4 |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05028-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROETHANE Date: 05/05/97
Route: GAVAGE Time: 08:33:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 6| 6| 5| 7| 7| 7| 6| 5| 7| 7| 5| 4| 3| |
DAY ON TEST | 3| 3| 3| 0| 3| 3| 3| 3| 9| 3| 3| 3| 5| 3| 7| 3| 3| 0| 8| 5| 3| 3| 8| 7| 2| |
| 4| 4| 4| 0| 6| 4| 4| 4| 2| 9| 4| 4| 3| 0| 7| 4| 4| 3| 2| 0| 4| 4| 7| 2| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
.02 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + M + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + M + + + + M| 45 |
Parasite Metazoan | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + M + + + + + + + A + + A + + + + + + +| 46 |
Parasite Metazoan | 3 4 | 4 2.5|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + A + + + + M + + + + +| 47 |
Parasite Metazoan | 2 2 4 3 | 8 2.5|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + M + + + A + + A + + + + + + +| 47 |
Parasite Metazoan | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | 1 X 1 X X X X 1 1 1 1 X 1 1 | 26 1.0|
Cytoplasmic Alteration, Focal | 2 | 2 2.0|
Fatty Change | 1 2 2 3 1 1 3 2 2 2| 22 1.8|
Fibrosis, Focal | 2 | 1 2.0|
Hepatodiaphragmatic Nodule | | 2 |
Mineralization, Focal | 2 | 1 2.0|
Necrosis, Focal | 1 1 2 1 1 1 1 3 2 1 3| 23 1.4|
Bile Duct, Hyperplasia | 2 1 3 3 2 3 2 3 3 2 1 3 3 2 2 2 2 4 2 2 3 2 | 42 2.3|
__________________________________________________________________________|____________|
Mesentery | + + M + | 5 |
Fat, Necrosis | 4 | 2 3.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 3 4 2 2 2 1 2 1| 11 2.3|
Acinus, Hyperplasia | 4 2 4 4 | 5 3.4|
Artery, Inflammation | 4 | 1 4.0|
__________________________________________________________________________|____________|
Pharynx | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Karyomegaly, Focal | | 2 2.5|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + A + + + + + + +| 49 |
Serosa, Fibrosis | | 1 4.0|
Serosa, Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + A + + + + + + +| 49 |
Acanthosis | 4 1 | 3 2.7|
Cyst Epithelial Inclusion | | 1 |
Hyperkeratosis | 4 | 2 4.0|
Hyperplasia, Basal Cell | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 05028-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROETHANE Date: 05/05/97
Route: GAVAGE Time: 08:33:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 6| 6| 5| 7| 7| 7| 6| 5| 7| 7| 5| 4| 3| |
DAY ON TEST | 3| 3| 3| 0| 3| 3| 3| 3| 9| 3| 3| 3| 5| 3| 7| 3| 3| 0| 8| 5| 3| 3| 8| 7| 2| |
| 4| 4| 4| 0| 6| 4| 4| 4| 2| 9| 4| 4| 3| 0| 7| 4| 4| 3| 2| 0| 4| 4| 7| 2| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
.02 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Ulcer | 3 | 3 3.3|
Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + A + + + + + + +| 49 |
Erosion | 2 | 1 2.0|
Infiltration Cellular, Lymphocyte | | 1 4.0|
Inflammation, Chronic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 3 3 2 3 4 3 2 4 2 4 2 4 2 3 3 2 3 1 3 2 2 4| 43 2.6|
Inflammation, Chronic | 3| 1 3.0|
Atrium, Dilatation | 4 4 4 | 3 4.0|
Atrium, Thrombosis | 4 4 X | 5 3.7|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cytoplasmic Alteration, Focal | 2 | 2 2.0|
Hyperplasia, Focal | | 2 1.5|
Hypertrophy | | 1 1.0|
Vacuolization Cytoplasmic | 2 | 2 1.5|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + M| 49 |
Hyperplasia, Focal | 2 4 2 2 2 | 10 2.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + M + + + + + + + + M + M| 43 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + M + + + + + + + + + + + + + + + + + + + + + +| 48 |
Pars Distalis, Cyst | | 2 |
Pars Distalis, Hyperplasia, Focal | 2 2 2 2 2 3 2 | 13 2.0|
Pars Distalis, Pigmentation, | | |
Hemosiderin | 3 | 1 3.0|
Pars Distalis, Vacuolization | | |
Cytoplasmic | 4 | 1 4.0|
Pars Intermedia, Cyst | | 1 |
Pars Nervosa, Cyst | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 4 4 1 2 | 11 2.5|
Follicle, Cyst | X X X X | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 05028-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROETHANE Date: 05/05/97
Route: GAVAGE Time: 08:33:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 6| 6| 5| 7| 7| 7| 6| 5| 7| 7| 5| 4| 3| |
DAY ON TEST | 3| 3| 3| 0| 3| 3| 3| 3| 9| 3| 3| 3| 5| 3| 7| 3| 3| 0| 8| 5| 3| 3| 8| 7| 2| |
| 4| 4| 4| 0| 6| 4| 4| 4| 2| 9| 4| 4| 3| 0| 7| 4| 4| 3| 2| 0| 4| 4| 7| 2| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
.02 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 | 2 2.5|
Dilatation, Focal | | 1 3.0|
Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Abscess | 2 | 3 3.3|
Ectasia | 3 4 | 2 3.5|
Inflammation, Acute | 3 | 4 2.8|
Inflammation, Chronic | 2 2 2 2 1 1 2 3 1| 18 1.8|
Inflammation, Chronic Active | 1 | 1 1.0|
Inflammation, Granulomatous | | 1 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + M + + + + + M + + + + + + + +| 48 |
Atrophy | 2 | 2 2.5|
Hyperplasia, Focal | 2 | 6 2.7|
Inflammation, Acute | 4 | 1 4.0|
Inflammation, Chronic | | 5 2.2|
Inflammation, Chronic Active | 2 | 1 2.0|
Metaplasia, Squamous | | 1 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + M + + + + + M + + + + + + + +| 48 |
Atrophy | 4 4 4 4 4 4 4 4 2 4 2 4 | 29 3.6|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Seminiferous Tubule, Atrophy | 1 | 3 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 3 3 2 3 3 | 7 2.7|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lumbar, Hyperplasia | | 1 2.0|
Mediastinal, Congestion | 4 2 3 | 3 3.0|
Mediastinal, Pigmentation, | | |
Hemosiderin | | 1 4.0|
Pancreatic, Pigmentation, Hemosiderin| 3 | 1 3.0|
Renal, Pigmentation, Hemosiderin | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + I + + + + + + + + + + + + + M + + M| 44 |
Angiectasis | 3 3 | 2 3.0|
Congestion | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05028-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROETHANE Date: 05/05/97
Route: GAVAGE Time: 08:33:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 6| 6| 5| 7| 7| 7| 6| 5| 7| 7| 5| 4| 3| |
DAY ON TEST | 3| 3| 3| 0| 3| 3| 3| 3| 9| 3| 3| 3| 5| 3| 7| 3| 3| 0| 8| 5| 3| 3| 8| 7| 2| |
| 4| 4| 4| 0| 6| 4| 4| 4| 2| 9| 4| 4| 3| 0| 7| 4| 4| 3| 2| 0| 4| 4| 7| 2| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
.02 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Infiltration Cellular, Plasma Cell | 3 3 3 3 2 2 3 2 3 2 3 3 4 | 29 3.1|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + M + + + + + A + + + + + + +| 48 |
Congestion | 4 3 | 2 3.5|
Cyst | | 1 |
Hyperplasia, Lymphoid | 4 4 | 2 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 2.0|
Depletion Lymphoid | 2 | 1 2.0|
Fibrosis, Focal | 3 | 1 3.0|
Hematopoietic Cell Proliferation | 4 2 | 8 2.4|
Pigmentation, Hemosiderin | 3 3 3 2 2 3| 11 2.7|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + M + + + + A + + I + + + +| 43 |
Hyperplasia, Lymphoid | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M + M M M + M M M M M M + M + + + M M + + M +| 23 |
Hemorrhage | 3 | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | X X | 3 |
Hyperkeratosis | 4 | 1 4.0|
Subcutaneous Tissue, Fibrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage, Focal | 1 1| 3 1.3|
Hydrocephalus | 3 3 2 3 | 5 2.6|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 4 4| 2 4.0|
Foreign Body | | 1 3.0|
Granuloma | 4 | 4 2.5|
Alveolar Epithelium, Hyperplasia, | | |
Adenomatous | 2 | 2 2.5|
Alveolar Epithelium, Metaplasia, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05028-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROETHANE Date: 05/05/97
Route: GAVAGE Time: 08:33:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 6| 6| 5| 7| 7| 7| 6| 5| 7| 7| 5| 4| 3| |
DAY ON TEST | 3| 3| 3| 0| 3| 3| 3| 3| 9| 3| 3| 3| 5| 3| 7| 3| 3| 0| 8| 5| 3| 3| 8| 7| 2| |
| 4| 4| 4| 0| 6| 4| 4| 4| 2| 9| 4| 4| 3| 0| 7| 4| 4| 3| 2| 0| 4| 4| 7| 2| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
.02 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Focal | | 2 2.5|
Artery, Ectasia | 4 | 1 4.0|
Peribronchial, Inflammation, Chronic | 2 1 2 2 2 3 2 2 2 2 2 2 2 2 2 1 | 32 1.9|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fungus | X | 2 |
Inflammation, Acute | 3 | 1 3.0|
Inflammation, Chronic | 3 2 3 2 3 3 2 3 1 2 3 3 3 2 1| 30 2.4|
Metaplasia, Squamous | 4 2 2 2 3 2 4 3 4 3 3 3 2 2 3 3 3 | 33 2.8|
Lymphatic, Angiectasis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 2 |
__________________________________________________________________________|____________|
Eye | + + | 2 |
Retina, Degeneration | 3 | 1 3.0|
Vitreous, Hemorrhage | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Casts | 1 | 2 2.5|
Cytomegaly | | 2 1.0|
Hyperplasia | 1 | 1 1.0|
Inflammation, Chronic | 1 | 2 1.5|
Mineralization | 2 2 3 2 3 3 1 2 3 3 3 3 2 4 2 | 32 2.4|
Nephropathy | 3 2 3 3 3 2 2 4 3 3 4 3 2 2 2 4 3 4 3 2 4 3 3 1 1| 47 2.9|
Pelvis, Transitional Epithelium, | | |
Hyperplasia | 2 2 2 | 7 2.4|
Renal Tubule, Cyst | | 1 |
Renal Tubule, Hyperplasia | 2 2 2 2 2 2 1 | 11 1.9|
Renal Tubule, Necrosis, Focal | 2| 1 2.0|
Renal Tubule, Pigmentation | 2 2 | 5 2.2|
Renal Tubule, Regeneration | 2 2| 3 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + A + + A + + + + + + +| 46 |
Concretion | 4 3 | 2 3.5|
Transitional Epithelium, Hyperplasia | | 1 3.0|
Wall, Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
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