TDMS Study 05028-01 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Mason DATE: 09/04/94
EXP: 05028 HEXACHLOROETHANE TIME: 09:45:16
TEST: 01 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 04604B
CONT: N01CP9561904 CAS: 67-72-1
PATHOLOGIST: A. RUSSFIELD
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Mason DATE: 09/04/94
EXP: 05028 HEXACHLOROETHANE TIME: 09:45:16
TEST: 01 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 04604B
CONT: N01CP9561904 CAS: 67-72-1
PATHOLOGIST: A. RUSSFIELD
HEXACHLOROETHANE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 733 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 18 CENSORED DEATHS 1 TERMINAL 31 |
| |
| UNCENSORED DEATHS |
| 353 406 530 568 585 589 630 637 638 646 |
| 646 654 666 667 687 714 720 726 |
| CENSORED DEATHS |
| 149 |
| |
|--------------------------------------------------------------------------------|
| DOSE = .01G/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 20 CENSORED DEATHS 1 TERMINAL 29 |
| |
| UNCENSORED DEATHS |
| 339 370 489 559 578 597 602 614 614 617 |
| 623 625 644 677 684 684 705 708 723 723 |
| CENSORED DEATHS |
| 665 |
| |
|--------------------------------------------------------------------------------|
| DOSE = .02G/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 23 CENSORED DEATHS 1 TERMINAL 26 |
| |
| UNCENSORED DEATHS |
| 359 467 472 483 534 550 558 577 586 587 |
| 613 630 632 636 639 649 653 682 692 700 |
| 703 709 724 |
| CENSORED DEATHS |
| 324 |
| |
==================================================================================
HEXACHLOROETHANE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 733 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 733 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE | 100.0 100.0 100.0 98.0 95.9 95.9 93.9 87.8 75.5 63.3 |
| | |
| | |
|.01G/KG | 100.0 100.0 100.0 98.0 96.0 96.0 94.0 86.0 74.0 59.6 |
| | |
| | |
|.02G/KG | 100.0 100.0 100.0 98.0 98.0 91.8 89.8 79.6 65.3 53.1 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE .01G/KG .02G/KG |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 63.3% 59.6% 53.1% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.290 P=0.806 P=0.332 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 614.6 608.8 601.5 |
|NATURAL DEATHS (C) | (23.7) (23.5) (19.3) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 678.7 681.9 664.3 |
|(STANDARD ERROR) | (15.9) (12.7) (14.5) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
HEXACHLOROETHANE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 731 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 18 CENSORED DEATHS 0 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 506 552 585 603 607 609 618 623 625 643 |
| 657 661 668 671 682 693 710 722 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = .08G/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 22 CENSORED DEATHS 1 TERMINAL 27 |
| |
| UNCENSORED DEATHS |
| 396 503 548 566 582 595 612 616 631 631 |
| 647 647 660 660 661 664 668 672 693 700 |
| 722 722 |
| CENSORED DEATHS |
| 660 |
| |
|--------------------------------------------------------------------------------|
| DOSE = .16G/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 18 CENSORED DEATHS 0 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 406 450 462 465 575 581 581 588 626 628 |
| 630 630 643 645 692 706 715 727 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
HEXACHLOROETHANE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 731 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 731 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE | 100.0 100.0 100.0 100.0 100.0 100.0 98.0 92.0 76.0 64.0 |
| | |
| | |
|.08G/KG | 100.0 100.0 100.0 100.0 98.0 98.0 96.0 88.0 67.9 55.5 |
| | |
| | |
|.16G/KG | 100.0 100.0 100.0 100.0 98.0 92.0 92.0 84.0 72.0 64.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE .08G/KG .16G/KG |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 64.0% 55.5% 64.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.955 P=0.498 P=1.000 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 635.3 627.1 597.2 |
|NATURAL DEATHS (C) | (13.0) (16.1) (22.5) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 696.5 683.9 682.8 |
|(STANDARD ERROR) | ( 8.0) (10.1) (12.1) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
HEXACHLOROETHANE
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE = 1
.01G/KG = 2
.02G/KG = 3
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 13
|
| 2 132 1 3
| 2 1 33 2 1
95 +
| 332 1 2 1
| 2 2
| 3 3 1 1
90 + 3 3 21 12
|
| 33 1 1
| 3 3 2 2 11
P 85 +
E | 33 11
R | 22
C | 11
E 80 + 3 3
N |
T | 322 11
| 2 2
S 75 + 33 1 1
U | 2 2
R | 22
V | 33 1 1
I 70 + 33 1 1
V |
A | 33 2 211
L | 22
65 + 3 3 11
| 33 2 1 1
|
| 33
60 + 2 2
| 33
| 33
|
55 + 3 3
|
| 3 3
|
50 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 4 obs hidden.
HEXACHLOROETHANE
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE = 1
.08G/KG = 2
.16G/KG = 3
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 23 1
|
| 23 3 21 1
| 33 2 1 1
95 +
| 33 2 2 1 1
| 3 2 32
|
90 + 2 2
|
P | 2 121
E | 33
R 85 +
C | 3 2112
E | 1 1
N |
T 80 + 2121
|
S | 1 1
U | 3 32 11
R 75 +
V | 33
I | 3 1 13
V |
A 70 + 11 3
L |
| 22 1 313
| 131
65 +
| 2 2 1 1
|
| 22
60 + 2 2
|
|
|
55 + 2 2
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 9 obs hidden.
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