TDMS Study 05035-03 Pathology Tables
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
Facility: TSI Mason Research
Chemical CAS #: 103-90-2
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 4| 7| 6| 7| 7| 4| 7| 6| 4| 7| 4| 4| 5| 6| 6| 5| 5| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 6| 3| 6| 3| 5| 3| 3| 6| 3| 7| 6| 3| 6| 6| 1| 6| 6| 9| 0| 6|
| 6| 6| 6| 6| 7| 3| 7| 3| 0| 2| 7| 7| 3| 7| 9| 4| 7| 4| 4| 7| 8| 4| 6| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
CONTROL | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + A + + + + + + + + A + + |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + A + + |
Parasite Metazoan | 4 2 4 2 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + |
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + A + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + A + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + + + + + + A + A + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + + |
Parasite Metazoan | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + |
Basophilic Focus | X X X X X X X X X X X X X |
Clear Cell Focus | |
Fatty Change | 1 3 2 1 3 2 1 2 |
Granuloma | 2 2 3 2 2 2 4 2 3 2 |
Hepatodiaphragmatic Nodule | X X |
Hyperplasia, Focal | |
Inflammation, Chronic, Focal | 2 |
Necrosis, Focal | 1 |
Bile Duct, Hyperplasia | 1 2 1 1 2 2 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + M + + + + + + + + + + |
Acinus, Atrophy, Focal | 4 3 4 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + |
Acanthosis | |
Diverticulum | |
Hyperkeratosis | 3 |
Hyperplasia, Basal Cell | 1 3 |
Ulcer | 4 |
Epithelium, Inflammation, Acute | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + A + + |
Inflammation, Chronic | 3 1 |
Mineralization | 2 |
Ulcer | |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 4| 7| 6| 7| 7| 4| 7| 6| 4| 7| 4| 4| 5| 6| 6| 5| 5| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 6| 3| 6| 3| 5| 3| 3| 6| 3| 7| 6| 3| 6| 6| 1| 6| 6| 9| 0| 6|
| 6| 6| 6| 6| 7| 3| 7| 3| 0| 2| 7| 7| 3| 7| 9| 4| 7| 4| 4| 7| 8| 4| 6| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
CONTROL | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Cardiomyopathy | 2 2 1 1 2 2 1 1 2 1 1 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + |
Atrophy | 4 |
Congestion | |
Cytoplasmic Alteration, Focal | 2 2 2 3 2 |
Hyperplasia | 2 |
Necrosis, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + M I + + + + + + + + + |
Hyperplasia, Focal | 2 |
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + M + M + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + M + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + M + + + + + + + |
Pars Distalis, Angiectasis | 3 2 |
Pars Distalis, Cyst | X X 2 X X X X X X |
Pars Distalis, Hemorrhage | 4 |
Pars Distalis, Hyperplasia, Focal | 2 1 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + A + + |
C-Cell, Hyperplasia | 2 1 1 1 2 1 1 1 2 1 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + M + + + + + + + + + + |
Abscess | 2 2 |
Cyst | |
Ectasia | 4 |
Inflammation, Acute | 2 |
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + M + + + + + |
Cyst | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + M + + + + + |
Angiectasis | 2 |
Atrophy | 3 |
Inflammation, Chronic Active | 3 |
Mineralization, Focal | 3 |
Prolapse | X |
Thrombosis | X |
Endometrium, Hyperplasia, Cystic | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 4| 7| 6| 7| 7| 4| 7| 6| 4| 7| 4| 4| 5| 6| 6| 5| 5| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 6| 3| 6| 3| 5| 3| 3| 6| 3| 7| 6| 3| 6| 6| 1| 6| 6| 9| 0| 6|
| 6| 6| 6| 6| 7| 3| 7| 3| 0| 2| 7| 7| 3| 7| 9| 4| 7| 4| 4| 7| 8| 4| 6| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
CONTROL | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + |
Hyperplasia | 2 2 2 2 |
Myelofibrosis | 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + |
Mediastinal, Congestion | |
Pancreatic, Congestion | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + M + + + + + + + + |
Congestion | |
Granuloma | |
Hyperplasia, Lymphoid | |
Infiltration Cellular, Plasma Cell | 3 3 2 2 3 2 3 2 2 4 3 3 4 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + |
Congestion | |
Granuloma | 2 2 2 2 4 2 2 2 2 2 2 2 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + |
Granuloma | 4 |
Hematopoietic Cell Proliferation | 2 2 2 2 4 2 2 2 2 2 3 |
Pigmentation, Hemosiderin | 2 2 2 2 2 2 3 |
__________________________________________________________________________|
Thymus | + + + + + + + M + + + + + + + + + + |
Congestion | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + + + + + M + + + + + + + + |
Ectasia | 4 |
Galactocele | X X X X X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + |
Abscess | |
Hyperkeratosis | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + |
Hyperostosis | X X |
__________________________________________________________________________|
Skeletal Muscle | |
Myopathy Degenerative | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + |
Hemorrhage | 4 2 |
Hydrocephalus | 4 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 4| 7| 6| 7| 7| 4| 7| 6| 4| 7| 4| 4| 5| 6| 6| 5| 5| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 6| 3| 6| 3| 5| 3| 3| 6| 3| 7| 6| 3| 6| 6| 1| 6| 6| 9| 0| 6|
| 6| 6| 6| 6| 7| 3| 7| 3| 0| 2| 7| 7| 3| 7| 9| 4| 7| 4| 4| 7| 8| 4| 6| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
CONTROL | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + |
Congestion | 3 |
Hemorrhage, Focal | 4 |
Infiltration Cellular, Histiocyte | 3 4 |
Alveolar Epithelium, Metaplasia | |
Peribronchial, Inflammation, Chronic | 2 2 2 1 1 2 2 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + A + + |
Fungus | 4 |
Hemorrhage | 4 |
Inflammation, Acute | 4 |
Inflammation, Chronic | 2 2 2 2 2 2 |
Metaplasia, Squamous | 2 2 2 3 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + |
__________________________________________________________________________|
Eye | + + + + |
__________________________________________________________________________|
Harderian Gland | + + + |
Inflammation, Chronic | |
Pigmentation | 2 4 2 |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + |
Abscess, Multiple | 3 |
Cyst | X |
Nephropathy | 1 2 1 2 1 2 2 2 2 1 1 1 1 1 2 1 3 1 |
Renal Tubule, Pigmentation | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + A + + + + + M A + A + + |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 6| 3| 3| 7| 6| 6| 5| 5| 7| 7| 4| 4| 7| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 3| 3| 3| 2| 2| 8| 2| 9| 8| 3| 4| 0| 7| 7| 3| 3| 6| 6| 0| 3| 3| 3| 9| 6|
| 7| 7| 7| 7| 9| 4| 3| 5| 6| 0| 7| 4| 7| 8| 5| 7| 7| 3| 3| 4| 7| 7| 7| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
CONTROL | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + A + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + A + + + + + + + +|
Parasite Metazoan | 2 3 3 3 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + A + + + + + + + +|
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A + + + + A + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + + + + + + +|
Parasite Metazoan | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X 3 X X X X X X|
Clear Cell Focus | X |
Fatty Change | 1 3 1 1 3 2 1|
Granuloma | 1 3 2 2 2 3 2 3 3 1 2|
Hepatodiaphragmatic Nodule | X X X X X X |
Hyperplasia, Focal | 2 2 2|
Inflammation, Chronic, Focal | |
Necrosis, Focal | |
Bile Duct, Hyperplasia | 2 1 2 2 2 2 2 1 |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis | 3 1 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + A + + + + + + + +|
Acinus, Atrophy, Focal | 2 2 2 2 3 2 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 |
Diverticulum | 4 |
Hyperkeratosis | 4 |
Hyperplasia, Basal Cell | 4 |
Ulcer | 2 4 |
Epithelium, Inflammation, Acute | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Mineralization | |
Ulcer | 4 |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 6| 3| 3| 7| 6| 6| 5| 5| 7| 7| 4| 4| 7| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 3| 3| 3| 2| 2| 8| 2| 9| 8| 3| 4| 0| 7| 7| 3| 3| 6| 6| 0| 3| 3| 3| 9| 6|
| 7| 7| 7| 7| 9| 4| 3| 5| 6| 0| 7| 4| 7| 8| 5| 7| 7| 3| 3| 4| 7| 7| 7| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
CONTROL | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Cardiomyopathy | 3 1 3 1 2 2 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Congestion | 4 |
Cytoplasmic Alteration, Focal | 2 2 2 2 |
Hyperplasia | 3 |
Necrosis, Focal | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + M + + M + I + + + I + + + A + + I + M I M +|
Hyperplasia, Focal | |
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + + + M M + + + + + + + + + M + I + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + A + + + + + + + +|
Pars Distalis, Angiectasis | 3 |
Pars Distalis, Cyst | X X X X X X X X X|
Pars Distalis, Hemorrhage | 3 |
Pars Distalis, Hyperplasia, Focal | 4 3 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 2 3 1 2 1 2 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + M + + M M + M + M + + + + + + + + +|
Abscess | 3 3 |
Cyst | |
Ectasia | |
Inflammation, Acute | 2 |
Inflammation, Chronic | 2 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Atrophy | |
Inflammation, Chronic Active | |
Mineralization, Focal | |
Prolapse | |
Thrombosis | X |
Endometrium, Hyperplasia, Cystic | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 6| 3| 3| 7| 6| 6| 5| 5| 7| 7| 4| 4| 7| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 3| 3| 3| 2| 2| 8| 2| 9| 8| 3| 4| 0| 7| 7| 3| 3| 6| 6| 0| 3| 3| 3| 9| 6|
| 7| 7| 7| 7| 9| 4| 3| 5| 6| 0| 7| 4| 7| 8| 5| 7| 7| 3| 3| 4| 7| 7| 7| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
CONTROL | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + A + + + + + + + +|
Hyperplasia | 2 3 |
Myelofibrosis | 1 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Congestion | 3 |
Pancreatic, Congestion | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M + M + + + + A + M M + M + + +|
Congestion | 2 |
Granuloma | 2 |
Hyperplasia, Lymphoid | 2 |
Infiltration Cellular, Plasma Cell | 2 4 2 4 2 4 2 4 2 2 3 2|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + M + + + + + + + +|
Congestion | 4 |
Granuloma | 2 2 2 3 2 2 2 2 2 4 3 2 2 2 3 2|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma | 4 |
Hematopoietic Cell Proliferation | 2 2 2 2 4 2 4 2 2 2 2 2 2 2 2 2|
Pigmentation, Hemosiderin | 3 3 2 3 2 3 2 2 2 2 2|
__________________________________________________________________________|
Thymus | + M + + M M M + + + M + + + + + M M + + + M M|
Congestion | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + M + +|
Ectasia | 3 3 4 3 2 4 4|
Galactocele | X X X X X X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 2 |
Hyperkeratosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | X X |
__________________________________________________________________________|
Skeletal Muscle | + |
Myopathy Degenerative | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Hydrocephalus | 2 2 2 3 2 3|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 6| 3| 3| 7| 6| 6| 5| 5| 7| 7| 4| 4| 7| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 3| 3| 3| 2| 2| 8| 2| 9| 8| 3| 4| 0| 7| 7| 3| 3| 6| 6| 0| 3| 3| 3| 9| 6|
| 7| 7| 7| 7| 9| 4| 3| 5| 6| 0| 7| 4| 7| 8| 5| 7| 7| 3| 3| 4| 7| 7| 7| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
CONTROL | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 1 1 |
Hemorrhage, Focal | 2 1 |
Infiltration Cellular, Histiocyte | |
Alveolar Epithelium, Metaplasia | 3 |
Peribronchial, Inflammation, Chronic | 1 2 1 2 1 1 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + A + + + + + + + +|
Fungus | X 3 |
Hemorrhage | 2 |
Inflammation, Acute | 2 2 |
Inflammation, Chronic | 2 2 3 2 2 2 2 2 |
Metaplasia, Squamous | 3 2 2 2 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 2 2 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + + + + |
__________________________________________________________________________|
Harderian Gland | + + + + + |
Inflammation, Chronic | 2 2 |
Pigmentation | 3 2 2 3 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + +|
Abscess, Multiple | |
Cyst | |
Nephropathy | 1 1 1 4 3 1 1 1 1 1 1 2 1 1 1 3 2 2 1 1 1|
Renal Tubule, Pigmentation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + A + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 7| 6| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
CONTROL | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + | 47 |
Parasite Metazoan | 4 2 | 2 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + | 48 |
Parasite Metazoan | | 10 2.7|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + | 49 |
Parasite Metazoan | | 2 2.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + A | 43 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + | 48 |
Parasite Metazoan | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + | 50 |
Basophilic Focus | X X X X X X X X X | 38 3.0|
Clear Cell Focus | | 1 |
Fatty Change | | 15 1.8|
Granuloma | 2 2 1 3 3 | 26 2.3|
Hepatodiaphragmatic Nodule | X X | 10 |
Hyperplasia, Focal | 4 | 4 2.5|
Inflammation, Chronic, Focal | | 1 2.0|
Necrosis, Focal | 2 | 2 1.5|
Bile Duct, Hyperplasia | 2 | 15 1.7|
__________________________________________________________________________|____________|
Mesentery | + + | 6 |
Fat, Necrosis | 4 4 | 5 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + M | 47 |
Acinus, Atrophy, Focal | 3 1 2 | 15 2.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + | 50 |
Acanthosis | | 1 3.0|
Diverticulum | | 1 4.0|
Hyperkeratosis | | 2 3.5|
Hyperplasia, Basal Cell | 1 | 4 2.3|
Ulcer | | 3 3.3|
Epithelium, Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + | 49 |
Inflammation, Chronic | | 2 2.0|
Mineralization | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 7| 6| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
CONTROL | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + | 49 |
Cardiomyopathy | 3 2 3 2 2 3 3 2 | 27 1.9|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + | 50 |
Atrophy | | 1 4.0|
Congestion | 4 | 2 4.0|
Cytoplasmic Alteration, Focal | 4 2 2 | 12 2.3|
Hyperplasia | | 2 2.5|
Necrosis, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + | 39 |
Hyperplasia, Focal | 3 2 3 | 4 2.5|
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + M | 46 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + M + + + + | 42 |
__________________________________________________________________________|____________|
Pituitary Gland | + M + + + + + + + | 47 |
Pars Distalis, Angiectasis | 2 4 | 5 2.8|
Pars Distalis, Cyst | X X X X | 22 2.0|
Pars Distalis, Hemorrhage | | 2 3.5|
Pars Distalis, Hyperplasia, Focal | 3 | 7 2.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + | 49 |
C-Cell, Hyperplasia | 3 1 2 1 | 25 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + M + + + | 43 |
Abscess | 4 | 5 2.8|
Cyst | X | 1 |
Ectasia | | 1 4.0|
Inflammation, Acute | | 2 2.0|
Inflammation, Chronic | | 3 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 7| 6| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
CONTROL | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Cyst | | 4 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + | 49 |
Angiectasis | | 1 2.0|
Atrophy | | 1 3.0|
Inflammation, Chronic Active | | 1 3.0|
Mineralization, Focal | | 1 3.0|
Prolapse | | 1 |
Thrombosis | | 2 |
Endometrium, Hyperplasia, Cystic | | 2 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + + + | 31 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + | 49 |
Hyperplasia | | 6 2.2|
Myelofibrosis | 3 | 5 1.8|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + | 50 |
Mediastinal, Congestion | 4 | 2 3.5|
Pancreatic, Congestion | 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + | 43 |
Congestion | | 1 2.0|
Granuloma | 2 | 2 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
Infiltration Cellular, Plasma Cell | 2 3 3 3 4 3 | 32 2.8|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + M | 48 |
Congestion | | 1 4.0|
Granuloma | 3 2 2 2 2 2 3 2 | 36 2.3|
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + | 50 |
Granuloma | 4 | 3 4.0|
Hematopoietic Cell Proliferation | 2 2 2 2 3 2 | 33 2.2|
Pigmentation, Hemosiderin | 2 3 2 3 3 | 23 2.3|
__________________________________________________________________________|____________|
Thymus | + + + + M + + + + | 39 |
Congestion | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + M + + | 46 |
Ectasia | | 8 3.4|
Galactocele | | 13 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 7| 6| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
CONTROL | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Abscess | | 1 2.0|
Hyperkeratosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + | 49 |
Hyperostosis | X X X | 7 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Myopathy Degenerative | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + | 49 |
Hemorrhage | | 3 2.3|
Hydrocephalus | | 7 2.6|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + | 50 |
Congestion | | 3 1.7|
Hemorrhage, Focal | | 3 2.3|
Infiltration Cellular, Histiocyte | | 2 3.5|
Alveolar Epithelium, Metaplasia | | 1 3.0|
Peribronchial, Inflammation, Chronic | 2 2 1 2 2 | 20 1.6|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + | 47 |
Fungus | | 3 3.5|
Hemorrhage | | 2 3.0|
Inflammation, Acute | 2 | 4 2.5|
Inflammation, Chronic | 2 2 2 | 17 2.1|
Metaplasia, Squamous | 3 2 | 10 2.3|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 2 | 6 1.8|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 3 |
__________________________________________________________________________|____________|
Eye | | 9 |
__________________________________________________________________________|____________|
Harderian Gland | | 8 |
Inflammation, Chronic | | 2 2.0|
Pigmentation | | 7 2.6|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 7| 6| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
CONTROL | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + | 50 |
Abscess, Multiple | | 1 3.0|
Cyst | | 1 |
Nephropathy | 2 1 1 1 3 2 1 2 1 | 48 1.5|
Renal Tubule, Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + A | 44 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 4| 7| 7| 6| 4| 4| 7| 7| 7| 7| 6| 4| 4| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 6| 3| 6| 3| 3| 5| 6| 6| 3| 3| 3| 3| 9| 6| 6| 3| 3| 1| 3| 3| 3| 3| 7|
| 5| 5| 2| 5| 4| 6| 5| 5| 4| 3| 6| 6| 6| 5| 4| 3| 3| 6| 6| 0| 6| 6| 6| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.06% LF | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + M + + + + + + + +|
Parasite Metazoan | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + M + +|
Parasite Metazoan | 2 4 3|
__________________________________________________________________________|
Intestine Large, Rectum | + M + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 4 2 4 4 3 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + A + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X |
Fatty Change | 3 3|
Granuloma | 2 2 2 2 4 3 |
Hepatodiaphragmatic Nodule | X |
Hyperplasia, Focal | |
Necrosis, Focal | 1 1 2 |
Bile Duct, Hyperplasia | 4 1 4 2 1 2 2 |
Hepatocyte, Hyperplasia | 2 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Focal | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Basal Cell | 4 2 1 |
Ulcer | |
Perivascular, Inflammation, Chronic | |
Submucosa, Edema | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Inflammation, Subacute | 4 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 1 2 2 2 3 3 2 2 3 2 3 2 3|
Coronary Artery, Inflammation, | |
Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 4| 7| 7| 6| 4| 4| 7| 7| 7| 7| 6| 4| 4| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 6| 3| 6| 3| 3| 5| 6| 6| 3| 3| 3| 3| 9| 6| 6| 3| 3| 1| 3| 3| 3| 3| 7|
| 5| 5| 2| 5| 4| 6| 5| 5| 4| 3| 6| 6| 6| 5| 4| 3| 3| 6| 6| 0| 6| 6| 6| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.06% LF | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Congestion | 2 |
Cytoplasmic Alteration, Focal | 2 2 2 2 2 |
Hypertrophy | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + I + + + + + + + + + M + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 |
Pars Distalis, Cyst | X X X X X X X X X |
Pars Distalis, Hemorrhage | 3 |
Pars Distalis, Hyperplasia, Focal | 2 4 |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 2 2 1 2 1 4 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 3 |
Cyst | |
Inflammation, Acute | 3 |
Inflammation, Chronic | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Dilatation | 2 |
Prolapse | |
Thrombosis | X X |
Endometrium, Cyst | X X |
Endometrium, Hyperplasia, Cystic | 2 2 |
Serosa, Inflammation, Acute | |
__________________________________________________________________________|
Vagina | + |
Cyst | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 4| 7| 7| 6| 4| 4| 7| 7| 7| 7| 6| 4| 4| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 6| 3| 6| 3| 3| 5| 6| 6| 3| 3| 3| 3| 9| 6| 6| 3| 3| 1| 3| 3| 3| 3| 7|
| 5| 5| 2| 5| 4| 6| 5| 5| 4| 3| 6| 6| 6| 5| 4| 3| 3| 6| 6| 0| 6| 6| 6| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.06% LF | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + I + + + + + + + + + + +|
Hyperplasia | 3 3 2 2 3|
Myelofibrosis | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Congestion | 4 3|
Mediastinal, Granuloma | |
Renal, Angiectasis | |
Renal, Granuloma | |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + + + + + + + + + + + + +|
Congestion | |
Infiltration Cellular, Plasma Cell | 2 3 3 3 2 2 3 3 2 3 3 2 2 3 2 3|
Lymphatic, Angiectasis | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + A|
Congestion | 2 |
Granuloma | 2 2 2 4 2 2 2 2 2 2 3 2 2 3 |
Lymphatic, Angiectasis | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hematopoietic Cell Proliferation | 4 2 4 2 2 2 2 2 2 2 |
Pigmentation, Hemosiderin | 3 3 2 2 3 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + M + + + + + + M M M + A|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + M + +|
Abscess | |
Ectasia | |
Galactocele | X X X |
__________________________________________________________________________|
Skin | + + + + + M + + + + + + + + + + + + + +|
Abscess | 4 |
Ulcer | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 4 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | 4 |
Choroid Plexus, Perivascular, | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 4| 7| 7| 6| 4| 4| 7| 7| 7| 7| 6| 4| 4| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 6| 3| 6| 3| 3| 5| 6| 6| 3| 3| 3| 3| 9| 6| 6| 3| 3| 1| 3| 3| 3| 3| 7|
| 5| 5| 2| 5| 4| 6| 5| 5| 4| 3| 6| 6| 6| 5| 4| 3| 3| 6| 6| 0| 6| 6| 6| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.06% LF | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Congestion | 3 1 2 2 |
Peribronchial, Inflammation, Chronic | 2 2 2 2 2 2 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Fungus | X X |
Inflammation, Acute | 2 2 2 3 2 |
Inflammation, Chronic | 1 2 2 2 |
Metaplasia, Squamous | 2 2 2 2 4 2 2 |
Respiratory Epithelium, Degeneration,| |
Hyaline | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Eye | + + + + A|
Cornea, Inflammation, Acute, Focal | 2 |
Retina, Degeneration | 3 2 |
__________________________________________________________________________|
Harderian Gland | + + + |
Inflammation, Chronic | 2 |
Pigmentation | 1 3 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 1 1 1 1 3 1 1 1 1 4 1 2 1 2 4 1 1 2 1 1|
Artery, Inflammation, Subacute | 4 |
Renal Tubule, Cyst | |
Renal Tubule, Pigmentation | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + A + + + + + + + A|
Inflammation, Chronic | 2 1 |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 6| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 4| 6| 5| 6| 7| 5| 4| 4|
DAY ON TEST | 3| 6| 3| 3| 8| 3| 3| 3| 3| 9| 3| 6| 3| 3| 1| 3| 3| 6| 8| 8| 2| 3| 0| 6| 6|
| 6| 4| 6| 6| 9| 6| 6| 6| 6| 9| 6| 3| 6| 6| 6| 6| 6| 3| 9| 1| 7| 6| 1| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
0.06% LF | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + |
Parasite Metazoan | 2 2 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + |
Parasite Metazoan | 4 4 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + |
Parasite Metazoan | 2 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + A |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + A |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + |
Basophilic Focus | X X X X X X X X X X X X X X X X X |
Fatty Change | 4 |
Granuloma | 2 2 3 2 |
Hepatodiaphragmatic Nodule | X X X X X X |
Hyperplasia, Focal | |
Necrosis, Focal | 1 1 |
Bile Duct, Hyperplasia | 2 2 2 2 |
Hepatocyte, Hyperplasia | |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + M + + + + |
Acinus, Atrophy, Focal | 2 2 2 2 1 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Basal Cell | 2 2 |
Ulcer | 3 4 |
Perivascular, Inflammation, Chronic | 2 |
Submucosa, Edema | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Inflammation, Subacute | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + |
Cardiomyopathy | 2 2 2 2 2 2 3 2 3 |
Coronary Artery, Inflammation, | |
Chronic | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 6| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 4| 6| 5| 6| 7| 5| 4| 4|
DAY ON TEST | 3| 6| 3| 3| 8| 3| 3| 3| 3| 9| 3| 6| 3| 3| 1| 3| 3| 6| 8| 8| 2| 3| 0| 6| 6|
| 6| 4| 6| 6| 9| 6| 6| 6| 6| 9| 6| 3| 6| 6| 6| 6| 6| 3| 9| 1| 7| 6| 1| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
0.06% LF | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + |
Atrophy | |
Congestion | |
Cytoplasmic Alteration, Focal | 2 |
Hypertrophy | 4 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + M + + I + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + M + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + I + |
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + |
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | X X X X X X |
Pars Distalis, Hemorrhage | 4 |
Pars Distalis, Hyperplasia, Focal | 3 2 |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + |
C-Cell, Hyperplasia | 4 3 1 3 1 1 3 1 2 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + M + + + + + + + M + + |
Abscess | 3 |
Cyst | X X X X |
Inflammation, Acute | 4 |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + |
Atrophy | |
Cyst | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + |
Atrophy | |
Dilatation | 3 |
Prolapse | |
Thrombosis | |
Endometrium, Cyst | |
Endometrium, Hyperplasia, Cystic | |
Serosa, Inflammation, Acute | |
__________________________________________________________________________|
Vagina | |
Cyst | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 6| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 4| 6| 5| 6| 7| 5| 4| 4|
DAY ON TEST | 3| 6| 3| 3| 8| 3| 3| 3| 3| 9| 3| 6| 3| 3| 1| 3| 3| 6| 8| 8| 2| 3| 0| 6| 6|
| 6| 4| 6| 6| 9| 6| 6| 6| 6| 9| 6| 3| 6| 6| 6| 6| 6| 3| 9| 1| 7| 6| 1| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
0.06% LF | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 2 2 3 2 |
Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + M + + + + + + + + + + + + |
Mediastinal, Congestion | 2 |
Mediastinal, Granuloma | |
Renal, Angiectasis | |
Renal, Granuloma | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M + + + + + + + + + M + M |
Congestion | 3 |
Infiltration Cellular, Plasma Cell | 4 4 3 2 3 2 4 2 3 3 3 3 2 2 |
Lymphatic, Angiectasis | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + M + + + + + + + + + + + + |
Congestion | 4 |
Granuloma | 2 2 3 2 2 2 2 3 2 2 2 3 3 2 2 |
Lymphatic, Angiectasis | 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + |
Congestion | |
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 2 2 2 2 2 3 |
Pigmentation, Hemosiderin | 2 2 2 2 3 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Thymus | + + + + + + M + + + + + + + M + + + + + |
Cyst | 3 X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + M + + M + + + + + + + + + + + |
Abscess | 3 |
Ectasia | 4 |
Galactocele | X X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + M + + M + + + + M + |
Abscess | |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + |
Hyperostosis | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + |
Hydrocephalus | 3 2 2 |
Choroid Plexus, Perivascular, | |
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 6| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 4| 6| 5| 6| 7| 5| 4| 4|
DAY ON TEST | 3| 6| 3| 3| 8| 3| 3| 3| 3| 9| 3| 6| 3| 3| 1| 3| 3| 6| 8| 8| 2| 3| 0| 6| 6|
| 6| 4| 6| 6| 9| 6| 6| 6| 6| 9| 6| 3| 6| 6| 6| 6| 6| 3| 9| 1| 7| 6| 1| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
0.06% LF | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Congestion | |
Peribronchial, Inflammation, Chronic | 2 2 2 2 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + |
Abscess | |
Fungus | |
Inflammation, Acute | 4 2 |
Inflammation, Chronic | 3 3 3 3 3 3 3 3 3 2 2 |
Metaplasia, Squamous | 2 2 2 |
Respiratory Epithelium, Degeneration,| |
Hyaline | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Inflammation, Chronic | |
__________________________________________________________________________|
Eye | + + + + |
Cornea, Inflammation, Acute, Focal | |
Retina, Degeneration | |
__________________________________________________________________________|
Harderian Gland | + + + |
Inflammation, Chronic | |
Pigmentation | 2 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + |
Nephropathy | 4 1 1 3 2 1 1 2 1 1 1 2 4 2 1 2 1 1 1 |
Artery, Inflammation, Subacute | |
Renal Tubule, Cyst | X |
Renal Tubule, Pigmentation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + A |
Inflammation, Chronic | 1 1 2 |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 6| 6| 6| | |
DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 4| 2| 1| | |
| 6| 6| 6| 6| 6| 5| 6| 4| 6| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
0.06% LF | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + A + | 48 |
Parasite Metazoan | 4 2 3 | 7 2.6|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 49 |
Parasite Metazoan | 2 | 7 3.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 49 |
Parasite Metazoan | 2 4 | 9 3.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + A + | 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 50 |
Basophilic Focus | X X X X X X | 39 |
Fatty Change | 3 3 | 5 3.2|
Granuloma | 2 4 2 4 2 | 15 2.5|
Hepatodiaphragmatic Nodule | X | 8 |
Hyperplasia, Focal | 4 4 | 2 4.0|
Necrosis, Focal | | 5 1.2|
Bile Duct, Hyperplasia | 2 2 2 2 | 15 2.1|
Hepatocyte, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 3 |
Fat, Necrosis | | 2 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 49 |
Acinus, Atrophy, Focal | 1 2 2 3 2 | 12 1.9|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 50 |
Hyperplasia, Basal Cell | | 5 2.2|
Ulcer | 4 | 3 3.7|
Perivascular, Inflammation, Chronic | | 1 2.0|
Submucosa, Edema | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Tooth | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Inflammation, Subacute | | 1 4.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 6| 6| 6| | |
DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 4| 2| 1| | |
| 6| 6| 6| 6| 6| 5| 6| 4| 6| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
0.06% LF | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Cardiomyopathy | 3 2 2 2 2 | 29 2.2|
Coronary Artery, Inflammation, | | |
Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 50 |
Atrophy | | 1 2.0|
Congestion | | 1 2.0|
Cytoplasmic Alteration, Focal | 2 | 7 2.0|
Hypertrophy | | 2 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M + + + | 46 |
Hyperplasia | 2 | 2 2.5|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 50 |
Pars Distalis, Angiectasis | | 1 3.0|
Pars Distalis, Cyst | X X X X X | 20 |
Pars Distalis, Hemorrhage | | 2 3.5|
Pars Distalis, Hyperplasia, Focal | 2 2 | 6 2.5|
Pars Intermedia, Cyst | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 50 |
C-Cell, Hyperplasia | 3 1 2 1 2 4 | 26 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + M + + + + + | 47 |
Abscess | | 3 3.3|
Cyst | X | 5 |
Inflammation, Acute | | 2 3.5|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 50 |
Atrophy | 3 | 2 2.5|
Cyst | | 3 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 50 |
Atrophy | 3 | 2 3.0|
Dilatation | | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 6| 6| 6| | |
DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 4| 2| 1| | |
| 6| 6| 6| 6| 6| 5| 6| 4| 6| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
0.06% LF | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Prolapse | X | 1 |
Thrombosis | | 2 |
Endometrium, Cyst | | 2 |
Endometrium, Hyperplasia, Cystic | | 2 2.0|
Serosa, Inflammation, Acute | 4 | 1 4.0|
__________________________________________________________________________|____________|
Vagina | | 1 |
Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + | 6 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 49 |
Hyperplasia | 3 2 3 | 12 2.5|
Myelofibrosis | | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 49 |
Mediastinal, Congestion | | 3 3.0|
Mediastinal, Granuloma | 3 | 1 3.0|
Renal, Angiectasis | 3 | 1 3.0|
Renal, Granuloma | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 46 |
Congestion | | 1 3.0|
Infiltration Cellular, Plasma Cell | 2 2 2 3 4 4 3 2 | 38 2.7|
Lymphatic, Angiectasis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 48 |
Congestion | | 2 3.0|
Granuloma | 2 2 2 2 2 3 2 3 3 | 38 2.3|
Lymphatic, Angiectasis | | 2 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 50 |
Congestion | 4 | 1 4.0|
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 | 29 2.2|
Pigmentation, Hemosiderin | 2 3 2 2 | 22 2.3|
__________________________________________________________________________|____________|
Thymus | + + + + + + M + + + | 42 |
Cyst | | 2 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 47 |
Abscess | | 1 3.0|
Ectasia | 4 | 2 4.0|
Galactocele | X X | 8 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 46 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 6| 6| 6| | |
DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 4| 2| 1| | |
| 6| 6| 6| 6| 6| 5| 6| 4| 6| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
0.06% LF | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Abscess | | 1 4.0|
Ulcer | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 50 |
Hyperostosis | X | 3 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 50 |
Hydrocephalus | 2 | 5 2.6|
Choroid Plexus, Perivascular, | | |
Inflammation, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 50 |
Congestion | 4 | 5 2.4|
Peribronchial, Inflammation, Chronic | 2 2 2 2 2 | 18 1.9|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 50 |
Abscess | | 1 4.0|
Fungus | | 2 |
Inflammation, Acute | | 7 2.4|
Inflammation, Chronic | 2 2 3 3 3 3 | 21 2.6|
Metaplasia, Squamous | 2 3 3 2 | 14 2.3|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Eye | + + + | 11 |
Cornea, Inflammation, Acute, Focal | | 1 2.0|
Retina, Degeneration | | 2 2.5|
__________________________________________________________________________|____________|
Harderian Gland | + + | 8 |
Inflammation, Chronic | | 1 2.0|
Pigmentation | 2 2 | 7 2.1|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 6| 6| 6| | |
DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 4| 2| 1| | |
| 6| 6| 6| 6| 6| 5| 6| 4| 6| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
0.06% LF | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Nephropathy | 2 3 3 1 1 1 1 1 1 2 | 49 1.6|
Artery, Inflammation, Subacute | | 1 4.0|
Renal Tubule, Cyst | | 1 |
Renal Tubule, Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + M + + A + | 45 |
Inflammation, Chronic | 2 | 6 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 4| 7| 7| 7| 4| 7| 5| 4| 7| 7| 7| 4| 5|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 6| 6| 3| 3| 6| 3| 1| 3| 6| 3| 0| 6| 3| 3| 3| 6| 3|
| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| 2| 2| 3| 2| 5| 5| 3| 5| 6| 4| 5| 5| 5| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.3% MF | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 3 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + M + + + + + +|
Parasite Metazoan | 2 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 3 2 2 2 |
Artery, Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X |
Cyst | |
Fatty Change | 2 2|
Granuloma | 3 1 |
Hepatodiaphragmatic Nodule | X X X X |
Hyperplasia, Focal | 3 2 |
Hyperplasia, Multifocal | |
Necrosis, Focal | 1 1 1 2 |
Bile Duct, Cyst | |
Bile Duct, Hyperplasia | 2 3 2 2 2 |
Perivascular, Inflammation, Chronic | 1 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 4 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Edema | 2 |
Acinus, Atrophy, Focal | 3 2 2 3 2|
Artery, Inflammation, Chronic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 |
Hyperkeratosis | |
Ulcer | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
Artery, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 4| 7| 7| 7| 4| 7| 5| 4| 7| 7| 7| 4| 5|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 6| 6| 3| 3| 6| 3| 1| 3| 6| 3| 0| 6| 3| 3| 3| 6| 3|
| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| 2| 2| 3| 2| 5| 5| 3| 5| 6| 4| 5| 5| 5| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.3% MF | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 3 2 2 3 3 2 2 3 2 2 1 |
Artery, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Cytoplasmic Alteration, Focal | 2 2|
Necrosis, Focal | |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + M M + M + + + M + M + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Cyst | X X X X X X |
Pars Distalis, Hemorrhage | |
Pars Distalis, Hyperplasia, Focal | 1 1 2 |
Pars Intermedia, Cyst | |
Pars Intermedia, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 3 2 1 2 1 1 1 |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + M M M + + + + + M + + + + + M M +|
Abscess | |
Cyst | X X |
Ectasia | |
Fibrosis | 2 |
Inflammation, Chronic | 2 4 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Atrophy | 4 |
Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Thrombosis | |
Endometrium, Cyst | |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 4| 7| 7| 7| 4| 7| 5| 4| 7| 7| 7| 4| 5|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 6| 6| 3| 3| 6| 3| 1| 3| 6| 3| 0| 6| 3| 3| 3| 6| 3|
| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| 2| 2| 3| 2| 5| 5| 3| 5| 6| 4| 5| 5| 5| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.3% MF | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + I + + + + + + +|
Hyperplasia | 1 1 3|
Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + +|
Mediastinal, Congestion | |
Mediastinal, Lymphatic, Angiectasis | |
Renal, Congestion | |
Renal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + M + + + + M + M + +|
Congestion | 2 |
Infiltration Cellular, Plasma Cell | 2 3 2 4 2 2 2 3 2 3 3 2 2 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + +|
Congestion | 2 2 |
Granuloma | 2 2 2 2 3 2 2 3 2 2 3 2 |
Artery, Inflammation, Acute | |
Artery, Thrombosis | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + +|
Granuloma | |
Hematopoietic Cell Proliferation | 3 2 2 3 4 2 2 |
Hemorrhage | 3 |
Infarct | |
Pigmentation, Hemosiderin | 2 3 2 2 3 2 2 3 2 3 2 2 |
Capsule, Hemorrhage | 3 |
__________________________________________________________________________|
Thymus | + + M + M + + + + + M M M + + + M M +|
Congestion | |
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + M + + + + + + M +|
Ectasia | |
Galactocele | X X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + +|
Hyperostosis | X X X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hydrocephalus | |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 4| 7| 7| 7| 4| 7| 5| 4| 7| 7| 7| 4| 5|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 6| 6| 3| 3| 6| 3| 1| 3| 6| 3| 0| 6| 3| 3| 3| 6| 3|
| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| 2| 2| 3| 2| 5| 5| 3| 5| 6| 4| 5| 5| 5| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.3% MF | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Fungus | |
Hemorrhage, Focal | 2 |
Peribronchial, Inflammation, Chronic | 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 3 3 2 2 2 3 2 |
Metaplasia, Squamous | 2 2 2 2 2 2 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Ulcer, Multifocal | |
__________________________________________________________________________|
Eye | + + + |
Retina, Degeneration | 3 |
__________________________________________________________________________|
Harderian Gland | + + |
Inflammation, Chronic | |
Pigmentation | 3 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + +|
Nephropathy | 2 1 3 1 2 2 3 1 1 4 1 2 1 2 2 2 1|
Artery, Inflammation, Chronic | |
Renal Tubule, Degeneration | |
Renal Tubule, Pigmentation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Artery, Inflammation, Chronic | 4 |
Transitional Epithelium, Hyperplasia,| |
Focal | 3 |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 7| 6| 5| 7| 7| 7| 5| 4| 7| 7| 7| 6| 4| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 7| 1| 5| 3| 3| 3| 1| 9| 3| 3| 3| 7| 6| 3| 3| 3| 4| 6| 3| 3| 3| 1| 9|
| 5| 5| 6| 1| 6| 5| 5| 5| 3| 1| 5| 5| 5| 0| 4| 5| 2| 2| 4| 3| 5| 5| 5| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.3% MF | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 3 4 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 4 2 2 4 |
Artery, Inflammation, Chronic | 3 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X |
Cyst | X |
Fatty Change | 2 2 2 3 2 2 2|
Granuloma | 1 3 2 |
Hepatodiaphragmatic Nodule | X X X |
Hyperplasia, Focal | |
Hyperplasia, Multifocal | 2 |
Necrosis, Focal | |
Bile Duct, Cyst | X |
Bile Duct, Hyperplasia | 3 2 2 3 2 1 4 |
Perivascular, Inflammation, Chronic | |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis | 4 4 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + M + +|
Angiectasis | 2 |
Edema | |
Acinus, Atrophy, Focal | 2 2 1 |
Artery, Inflammation, Chronic | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 |
Hyperkeratosis | 4 |
Ulcer | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Artery, Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 7| 6| 5| 7| 7| 7| 5| 4| 7| 7| 7| 6| 4| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 7| 1| 5| 3| 3| 3| 1| 9| 3| 3| 3| 7| 6| 3| 3| 3| 4| 6| 3| 3| 3| 1| 9|
| 5| 5| 6| 1| 6| 5| 5| 5| 3| 1| 5| 5| 5| 0| 4| 5| 2| 2| 4| 3| 5| 5| 5| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.3% MF | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 2 2 3 2 2 2 2 2 3 2 |
Artery, Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Cytoplasmic Alteration, Focal | 2 2 2 |
Necrosis, Focal | 3|
Vacuolization Cytoplasmic | 4 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + M + + + + M + + M M + + + + + + I + M + +|
Hyperplasia, Focal | 2 2 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + I + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Parathyroid Gland | + I M + + + + + + + M + M + M + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 4 |
Pars Distalis, Cyst | X X X X X X X X |
Pars Distalis, Hemorrhage | 4 |
Pars Distalis, Hyperplasia, Focal | 4 2 2 3 2 2|
Pars Intermedia, Cyst | |
Pars Intermedia, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 3 2 1 2 2 3 4 1 1 1 2 |
Follicle, Cyst | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 3 |
Cyst | X X |
Ectasia | 4 |
Fibrosis | |
Inflammation, Chronic | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Atrophy | |
Cyst | X X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Thrombosis | X |
Endometrium, Cyst | X X X |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 7| 6| 5| 7| 7| 7| 5| 4| 7| 7| 7| 6| 4| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 7| 1| 5| 3| 3| 3| 1| 9| 3| 3| 3| 7| 6| 3| 3| 3| 4| 6| 3| 3| 3| 1| 9|
| 5| 5| 6| 1| 6| 5| 5| 5| 3| 1| 5| 5| 5| 0| 4| 5| 2| 2| 4| 3| 5| 5| 5| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.3% MF | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 2|
Myelofibrosis | 3 4 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Congestion | |
Mediastinal, Lymphatic, Angiectasis | 3 |
Renal, Congestion | 4 |
Renal, Pigmentation | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M + + + + + + + + + + + + + + +|
Congestion | 3 |
Infiltration Cellular, Plasma Cell | 4 3 3 2 2 2 3 2 2 3 2 2 3 2 3 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Granuloma | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 3 |
Artery, Inflammation, Acute | 3 |
Artery, Thrombosis | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma | 2 |
Hematopoietic Cell Proliferation | 2 2 2 3 2 2 2 2 2 2 2 |
Hemorrhage | |
Infarct | 3 |
Pigmentation, Hemosiderin | 2 2 3 3 3 2 3 3 2 3 2 3 3 3 |
Capsule, Hemorrhage | |
__________________________________________________________________________|
Thymus | + M + M + + + + + M + M + M + + + + + + + + +|
Congestion | |
Cyst | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 3 4 |
Galactocele | X X X X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + I|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | X X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 2|
Hydrocephalus | 2 2 2 2 3 |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 7| 6| 5| 7| 7| 7| 5| 4| 7| 7| 7| 6| 4| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 7| 1| 5| 3| 3| 3| 1| 9| 3| 3| 3| 7| 6| 3| 3| 3| 4| 6| 3| 3| 3| 1| 9|
| 5| 5| 6| 1| 6| 5| 5| 5| 3| 1| 5| 5| 5| 0| 4| 5| 2| 2| 4| 3| 5| 5| 5| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.3% MF | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 4 |
Fungus | X |
Hemorrhage, Focal | |
Peribronchial, Inflammation, Chronic | 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 2 2 2 2 2 |
Metaplasia, Squamous | 2 3 2 2 2 3 2 2 2 2|
Respiratory Epithelium, Degeneration,| |
Hyaline | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Ulcer, Multifocal | |
__________________________________________________________________________|
Eye | + + + |
Retina, Degeneration | |
__________________________________________________________________________|
Harderian Gland | + + + |
Inflammation, Chronic | 1 |
Pigmentation | 2 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 3 3 1 4 1 2 3 2 1 3 1 1 1 1 1 2 2 1 2 1 1 2 1|
Artery, Inflammation, Chronic | 3 |
Renal Tubule, Degeneration | 2 |
Renal Tubule, Pigmentation | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Artery, Inflammation, Chronic | |
Transitional Epithelium, Hyperplasia,| |
Focal | 2 |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 3| 4| 7| 4| 5| 4| | |
DAY ON TEST | 3| 3| 3| 8| 7| 6| 3| 6| 1| 8| | |
| 5| 5| 5| 9| 2| 4| 5| 3| 9| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
0.3% MF | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + | 50 |
Parasite Metazoan | | 4 3.3|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + | 49 |
Parasite Metazoan | | 3 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + | 50 |
Parasite Metazoan | | 9 2.6|
Artery, Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + | 50 |
Artery, Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + A | 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + | 50 |
Basophilic Focus | X X X X X | 32 |
Cyst | | 1 |
Fatty Change | 3 3 | 11 2.3|
Granuloma | 2 2 | 7 2.0|
Hepatodiaphragmatic Nodule | X | 8 |
Hyperplasia, Focal | | 2 2.5|
Hyperplasia, Multifocal | | 1 2.0|
Necrosis, Focal | 4 | 5 1.8|
Bile Duct, Cyst | | 1 |
Bile Duct, Hyperplasia | 2 | 13 2.3|
Perivascular, Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | + | 6 |
Fat, Necrosis | 4 | 6 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 49 |
Angiectasis | | 1 2.0|
Edema | | 1 2.0|
Acinus, Atrophy, Focal | 2 | 9 2.1|
Artery, Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + | 50 |
Acanthosis | | 2 2.5|
Hyperkeratosis | | 1 4.0|
Ulcer | | 2 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 3| 4| 7| 4| 5| 4| | |
DAY ON TEST | 3| 3| 3| 8| 7| 6| 3| 6| 1| 8| | |
| 5| 5| 5| 9| 2| 4| 5| 3| 9| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
0.3% MF | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + | 50 |
Inflammation, Chronic | | 2 2.5|
Artery, Inflammation, Chronic | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + | 50 |
Cardiomyopathy | 2 2 2 2 2 | 28 2.2|
Artery, Inflammation, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + | 50 |
Atrophy | | 1 4.0|
Cytoplasmic Alteration, Focal | 2 | 6 2.0|
Necrosis, Focal | | 1 3.0|
Vacuolization Cytoplasmic | | 1 4.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + | 44 |
Hyperplasia, Focal | | 5 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M + + + + + + | 37 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + | 50 |
Pars Distalis, Angiectasis | 3 2 | 4 2.8|
Pars Distalis, Cyst | X X X | 17 |
Pars Distalis, Hemorrhage | | 1 4.0|
Pars Distalis, Hyperplasia, Focal | 2 | 10 2.1|
Pars Intermedia, Cyst | X | 1 |
Pars Intermedia, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + | 50 |
C-Cell, Hyperplasia | 3 | 21 1.9|
Follicle, Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + M + | 43 |
Abscess | 4 | 2 3.5|
Cyst | | 4 |
Ectasia | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 3| 4| 7| 4| 5| 4| | |
DAY ON TEST | 3| 3| 3| 8| 7| 6| 3| 6| 1| 8| | |
| 5| 5| 5| 9| 2| 4| 5| 3| 9| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
0.3% MF | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Fibrosis | | 1 2.0|
Inflammation, Chronic | | 2 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + | 50 |
Angiectasis | 2 | 1 2.0|
Atrophy | | 1 4.0|
Cyst | X | 6 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + | 50 |
Atrophy | | 2 2.5|
Thrombosis | | 1 |
Endometrium, Cyst | | 3 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 4 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + | 49 |
Hyperplasia | 3 | 7 2.1|
Myelofibrosis | 4 | 5 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + | 50 |
Mediastinal, Congestion | 3 | 1 3.0|
Mediastinal, Lymphatic, Angiectasis | | 1 3.0|
Renal, Congestion | | 1 4.0|
Renal, Pigmentation | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + I + + + + + + | 45 |
Congestion | | 2 2.5|
Infiltration Cellular, Plasma Cell | 3 2 2 2 4 | 35 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + | 49 |
Congestion | | 3 2.0|
Granuloma | 2 2 2 2 2 3 | 34 2.2|
Artery, Inflammation, Acute | | 1 3.0|
Artery, Thrombosis | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + | 50 |
Granuloma | | 1 2.0|
Hematopoietic Cell Proliferation | 2 2 2 4 2 | 23 2.3|
Hemorrhage | | 1 3.0|
Infarct | | 1 3.0|
Pigmentation, Hemosiderin | 2 3 | 28 2.5|
Capsule, Hemorrhage | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | M + + + + + + M | 36 |
Congestion | 3 | 1 3.0|
Cyst | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 3| 4| 7| 4| 5| 4| | |
DAY ON TEST | 3| 3| 3| 8| 7| 6| 3| 6| 1| 8| | |
| 5| 5| 5| 9| 2| 4| 5| 3| 9| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
0.3% MF | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + | 48 |
Ectasia | 2 | 4 2.8|
Galactocele | X X | 10 |
__________________________________________________________________________|____________|
Skin | + M + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + | 50 |
Hyperostosis | X | 6 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + | 50 |
Hemorrhage | | 2 2.0|
Hydrocephalus | | 5 2.2|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + | 50 |
Congestion | | 2 3.0|
Fungus | | 1 |
Hemorrhage, Focal | | 1 2.0|
Peribronchial, Inflammation, Chronic | 2 3 2 1 2 | 22 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + | 50 |
Inflammation, Chronic | 3 | 16 2.3|
Metaplasia, Squamous | 2 2 | 18 2.1|
Respiratory Epithelium, Degeneration,| | |
Hyaline | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
Ulcer, Multifocal | 4 | 1 4.0|
__________________________________________________________________________|____________|
Eye | + | 7 |
Retina, Degeneration | | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | | 5 |
Inflammation, Chronic | | 1 1.0|
Pigmentation | | 4 2.3|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 3| 4| 7| 4| 5| 4| | |
DAY ON TEST | 3| 3| 3| 8| 7| 6| 3| 6| 1| 8| | |
| 5| 5| 5| 9| 2| 4| 5| 3| 9| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
0.3% MF | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + | 50 |
Nephropathy | 2 1 2 1 2 1 1 | 47 1.7|
Artery, Inflammation, Chronic | | 1 3.0|
Renal Tubule, Degeneration | | 1 2.0|
Renal Tubule, Pigmentation | 2 | 2 2.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + A | 49 |
Inflammation, Chronic | | 2 2.0|
Artery, Inflammation, Chronic | | 1 4.0|
Transitional Epithelium, Hyperplasia,| | |
Focal | 2 | 3 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 4| 7| 4| 7| 2| 7| 6| 7| 6| 6| 7| 7| 6| 5| 5| 4| 7| 7| 7| 6|
DAY ON TEST | 2| 2| 2| 6| 1| 6| 2| 6| 2| 4| 3| 7| 0| 9| 4| 3| 3| 4| 8| 1| 6| 3| 3| 3| 5|
| 9| 9| 9| 2| 4| 3| 9| 4| 9| 5| 1| 8| 8| 3| 0| 1| 0| 0| 5| 9| 4| 2| 2| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.6% HF | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + M + M + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 2 4 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + M + + + + + + +|
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 4 3 4 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X |
Clear Cell Focus | X |
Fatty Change | 3 3 3 1 2 1 2 2 4 2 2|
Granuloma | 2 4 |
Hepatodiaphragmatic Nodule | X X |
Hyperplasia, Focal | 4 4 2 1 2 2|
Necrosis, Focal | 1 |
Bile Duct, Cyst | |
Bile Duct, Hyperplasia | 2 2 2 1 2 3 2 |
__________________________________________________________________________|
Mesentery | + + + +|
Fat, Necrosis | 3 4 4 4|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + M + + + + + + + + + +|
Angiectasis | 1 |
Acinus, Atrophy, Focal | 3 3 1 |
Duct, Ectasia | |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + M + + + + + + + + + + + + + + + + + + +|
Acanthosis | 4 |
Hyperkeratosis | 2 4|
Ulcer | 4|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 |
Mineralization | |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 1 2 2 2 2 3 2 2|
Artery, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 4| 7| 4| 7| 2| 7| 6| 7| 6| 6| 7| 7| 6| 5| 5| 4| 7| 7| 7| 6|
DAY ON TEST | 2| 2| 2| 6| 1| 6| 2| 6| 2| 4| 3| 7| 0| 9| 4| 3| 3| 4| 8| 1| 6| 3| 3| 3| 5|
| 9| 9| 9| 2| 4| 3| 9| 4| 9| 5| 1| 8| 8| 3| 0| 1| 0| 0| 5| 9| 4| 2| 2| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.6% HF | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Congestion | |
Cytoplasmic Alteration, Focal | 2 2 2 2 4 2|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + + + + + + + M + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 |
Pars Distalis, Cyst | X X X X X X X X X |
Pars Distalis, Hyperplasia, Focal | 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 2 2 1 2 3 |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M + + + + + M + + + M + + + + M + M M + + +|
Abscess | 3 |
Cyst | X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Cyst | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
__________________________________________________________________________|
Vagina | |
Metestrus | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + + |
Lymphocytosis | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 3 2 2 |
Myelofibrosis | 4 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Lymphatic, Angiectasis | |
Mediastinal, Infiltration Cellular, | |
Plasma Cell | 3 |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 4| 7| 4| 7| 2| 7| 6| 7| 6| 6| 7| 7| 6| 5| 5| 4| 7| 7| 7| 6|
DAY ON TEST | 2| 2| 2| 6| 1| 6| 2| 6| 2| 4| 3| 7| 0| 9| 4| 3| 3| 4| 8| 1| 6| 3| 3| 3| 5|
| 9| 9| 9| 2| 4| 3| 9| 4| 9| 5| 1| 8| 8| 3| 0| 1| 0| 0| 5| 9| 4| 2| 2| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.6% HF | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mandibular | + I + + + M + + + + + + + + + + + + + + + +|
Congestion | 2 |
Infiltration Cellular, Plasma Cell | 2 2 3 3 2 2 2 2 3 2 2 3 4 |
Lymphatic, Angiectasis | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 4 4|
Granuloma | 2 2 3 2 2 2 2 2 2 3 3 1 |
Infiltration Cellular, Plasma Cell | 4 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + +|
Granuloma | 2 |
Hematopoietic Cell Proliferation | 3 4 2 2 1 2 2 2 2 2 2|
Infarct | 4 |
Pigmentation, Hemosiderin | 2 2 2 2 3 2|
__________________________________________________________________________|
Thymus | + + + + + + M + + + M M + + + + + + M + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + M + + + + + + + +|
Ectasia | |
Galactocele | X X X X X |
Hypertrophy | 2 |
Inflammation, Acute | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + M + + + + + + + +|
Cyst Epithelial Inclusion | |
Hemorrhage, Focal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | X X X X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Hydrocephalus | 2 2 3 2 2 |
__________________________________________________________________________|
Peripheral Nerve | |
Degeneration | |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 1 |
Alveolar Epithelium, Metaplasia | |
Peribronchial, Inflammation, Chronic | 2 1 2 2 2 2 2 2 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 4| 7| 4| 7| 2| 7| 6| 7| 6| 6| 7| 7| 6| 5| 5| 4| 7| 7| 7| 6|
DAY ON TEST | 2| 2| 2| 6| 1| 6| 2| 6| 2| 4| 3| 7| 0| 9| 4| 3| 3| 4| 8| 1| 6| 3| 3| 3| 5|
| 9| 9| 9| 2| 4| 3| 9| 4| 9| 5| 1| 8| 8| 3| 0| 1| 0| 0| 5| 9| 4| 2| 2| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.6% HF | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Fungus | |
Inflammation, Acute | 3 |
Inflammation, Chronic | 2 1 2 2 2 2 |
Metaplasia, Squamous | 2 2 2 2 2 1 3 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + + + + |
Lens, Degeneration | |
Retina, Degeneration | |
__________________________________________________________________________|
Harderian Gland | + + + + |
Pigmentation | 4 2 3 2 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + +|
Calculus Gross Observation | |
Cyst | X |
Inflammation, Chronic | |
Nephropathy | 2 2 1 1 1 3 4 1 1 2 1 1 2 1 3 2 1 2 3 4|
Pelvis, Transitional Epithelium, | |
Hyperplasia | |
Renal Tubule, Hyperplasia | |
Renal Tubule, Pigmentation | 1 2 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + +|
Calculus Gross Observation | |
Inflammation, Chronic | 2 |
Transitional Epithelium, Hyperplasia,| |
Diffuse | |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
_____________________________________________________________________________________________________________________
| 7| 4| 7| 6| 4| 7| 7| 6| 6| 4| 4| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 6| 3| 2| 6| 3| 3| 3| 1| 7| 6| 3| 6| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 7| 6|
| 2| 3| 2| 8| 3| 2| 1| 9| 1| 1| 3| 2| 4| 2| 2| 0| 0| 3| 0| 0| 0| 0| 0| 2| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0.6% HF | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + M + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + |
Parasite Metazoan | 3 4 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + |
Parasite Metazoan | 4 2 2 2 2 3 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + |
Parasite Metazoan | 4 3 2 2 3 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + |
Basophilic Focus | X X X X X X X X X X |
Clear Cell Focus | X |
Fatty Change | 2 2 4 3 |
Granuloma | 2 2 3 1 1 |
Hepatodiaphragmatic Nodule | X X X |
Hyperplasia, Focal | 4 2 |
Necrosis, Focal | |
Bile Duct, Cyst | |
Bile Duct, Hyperplasia | 3 2 2 2 2 3 1 2 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + M + + + + + + + + + + + + + |
Angiectasis | |
Acinus, Atrophy, Focal | 1 2 |
Duct, Ectasia | 2 |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + |
Acanthosis | |
Hyperkeratosis | 3 3 |
Ulcer | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | |
Mineralization | |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + |
Cardiomyopathy | 2 2 2 1 2 1 2 1 2 2 |
Artery, Inflammation, Chronic | 4 |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
_____________________________________________________________________________________________________________________
| 7| 4| 7| 6| 4| 7| 7| 6| 6| 4| 4| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 6| 3| 2| 6| 3| 3| 3| 1| 7| 6| 3| 6| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 7| 6|
| 2| 3| 2| 8| 3| 2| 1| 9| 1| 1| 3| 2| 4| 2| 2| 0| 0| 3| 0| 0| 0| 0| 0| 2| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0.6% HF | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + M + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + M + + + + + |
Atrophy | |
Congestion | |
Cytoplasmic Alteration, Focal | 2 2 3 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + M + + + + + + + + M + M + + + |
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + M M + + + + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + M M + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + M + + + + + |
Pars Distalis, Angiectasis | 2 2 |
Pars Distalis, Cyst | X X X X X X X X |
Pars Distalis, Hyperplasia, Focal | 2 2 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + |
C-Cell, Hyperplasia | 2 2 1 1 4 1 1 |
Follicular Cell, Hyperplasia | 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + M + + + + M + M + |
Abscess | 3 3 |
Cyst | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + |
Congestion | 2 2 |
Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + |
Dilatation | 2 |
__________________________________________________________________________|
Vagina | + + |
Metestrus | X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + + + + |
Lymphocytosis | X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 3 2 2 2 2 3 |
Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + |
Inguinal, Lymphatic, Angiectasis | |
Mediastinal, Infiltration Cellular, | |
Plasma Cell | |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
_____________________________________________________________________________________________________________________
| 7| 4| 7| 6| 4| 7| 7| 6| 6| 4| 4| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 6| 3| 2| 6| 3| 3| 3| 1| 7| 6| 3| 6| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 7| 6|
| 2| 3| 2| 8| 3| 2| 1| 9| 1| 1| 3| 2| 4| 2| 2| 0| 0| 3| 0| 0| 0| 0| 0| 2| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0.6% HF | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + M M + + M + + + |
Congestion | |
Infiltration Cellular, Plasma Cell | 2 2 2 3 3 2 3 2 3 3 |
Lymphatic, Angiectasis | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + |
Congestion | |
Granuloma | 2 2 2 2 3 2 2 2 2 2 1 2 2 |
Infiltration Cellular, Plasma Cell | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + |
Granuloma | 4 3 |
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 |
Infarct | |
Pigmentation, Hemosiderin | 2 2 3 3 2 2 2 2 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + M + + + + M + M + |
Cyst | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + M + + M M + M + + |
Ectasia | 3 2 |
Galactocele | X X |
Hypertrophy | |
Inflammation, Acute | |
__________________________________________________________________________|
Skin | + + + + M + + + + + + + + + + + + + + |
Cyst Epithelial Inclusion | X |
Hemorrhage, Focal | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + |
Hyperostosis | X X X X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + |
Hemorrhage | |
Hydrocephalus | 2 |
__________________________________________________________________________|
Peripheral Nerve | + |
Degeneration | 2 |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + |
Congestion | |
Alveolar Epithelium, Metaplasia | 2 |
Peribronchial, Inflammation, Chronic | 3 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
_____________________________________________________________________________________________________________________
| 7| 4| 7| 6| 4| 7| 7| 6| 6| 4| 4| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 6| 3| 2| 6| 3| 3| 3| 1| 7| 6| 3| 6| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 7| 6|
| 2| 3| 2| 8| 3| 2| 1| 9| 1| 1| 3| 2| 4| 2| 2| 0| 0| 3| 0| 0| 0| 0| 0| 2| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0.6% HF | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Fungus | X 3 |
Inflammation, Acute | 2 2 2 |
Inflammation, Chronic | 3 2 2 2 2 3 1 |
Metaplasia, Squamous | 3 2 2 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + |
__________________________________________________________________________|
Eye | + + + + |
Lens, Degeneration | 1 3 |
Retina, Degeneration | 3 4 4 |
__________________________________________________________________________|
Harderian Gland | + |
Pigmentation | 3 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + |
Calculus Gross Observation | |
Cyst | |
Inflammation, Chronic | |
Nephropathy | 3 2 1 1 1 3 3 4 1 2 2 2 3 2 2 2 |
Pelvis, Transitional Epithelium, | |
Hyperplasia | 3 |
Renal Tubule, Hyperplasia | 1 |
Renal Tubule, Pigmentation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + |
Calculus Gross Observation | |
Inflammation, Chronic | |
Transitional Epithelium, Hyperplasia,| |
Diffuse | |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 6| 6| 5| 5| 3| 3| | |
DAY ON TEST | 3| 3| 6| 2| 6| 9| 8| 5| 5| 0| | |
| 0| 0| 4| 9| 8| 0| 5| 4| 4| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
0.6% HF | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + | 50 |
Parasite Metazoan | | 5 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + | 49 |
Parasite Metazoan | | 7 2.4|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + | 50 |
Parasite Metazoan | 2 2 | 10 2.9|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + | 50 |
Basophilic Focus | X X | 20 |
Clear Cell Focus | | 2 |
Fatty Change | 1 1 | 17 2.2|
Granuloma | 2 | 8 2.1|
Hepatodiaphragmatic Nodule | X | 6 |
Hyperplasia, Focal | | 8 2.6|
Necrosis, Focal | 1 | 2 1.0|
Bile Duct, Cyst | X | 1 |
Bile Duct, Hyperplasia | 1 4 3 1 | 19 2.1|
__________________________________________________________________________|____________|
Mesentery | + + | 8 |
Fat, Necrosis | 4 4 | 8 3.6|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + | 48 |
Angiectasis | | 1 1.0|
Acinus, Atrophy, Focal | 1 4 3 2 | 9 2.2|
Duct, Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Pharynx | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + | 49 |
Acanthosis | | 1 4.0|
Hyperkeratosis | | 4 3.0|
Ulcer | | 2 3.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + | 50 |
Inflammation, Chronic | 2 1 | 4 1.3|
Mineralization | 3 | 1 3.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 6| 6| 5| 5| 3| 3| | |
DAY ON TEST | 3| 3| 6| 2| 6| 9| 8| 5| 5| 0| | |
| 0| 0| 4| 9| 8| 0| 5| 4| 4| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
0.6% HF | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + | 50 |
Cardiomyopathy | 2 3 4 1 2 2 1 | 30 1.9|
Artery, Inflammation, Chronic | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + | 49 |
Atrophy | 3 | 1 3.0|
Congestion | 2 | 1 2.0|
Cytoplasmic Alteration, Focal | 2 2 3 | 13 2.4|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + | 47 |
Hyperplasia, Focal | 1 | 5 1.8|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + + M M | 42 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + | 49 |
Pars Distalis, Angiectasis | 2 | 4 2.3|
Pars Distalis, Cyst | X X X X X | 22 |
Pars Distalis, Hyperplasia, Focal | 3 2 2 2 | 9 2.2|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + | 50 |
C-Cell, Hyperplasia | 2 | 15 1.8|
Follicular Cell, Hyperplasia | | 3 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + M + | 40 |
Abscess | | 3 3.0|
Cyst | | 1 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + M | 49 |
Congestion | | 2 2.0|
Cyst | | 3 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + | 50 |
Dilatation | | 1 2.0|
__________________________________________________________________________|____________|
Vagina | | 2 |
Metestrus | | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 6| 6| 5| 5| 3| 3| | |
DAY ON TEST | 3| 3| 6| 2| 6| 9| 8| 5| 5| 0| | |
| 0| 0| 4| 9| 8| 0| 5| 4| 4| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
0.6% HF | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Blood | + + + | 29 |
Lymphocytosis | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + | 50 |
Hyperplasia | 3 2 2 3 | 17 2.3|
Myelofibrosis | | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + | 50 |
Inguinal, Lymphatic, Angiectasis | 4 | 1 4.0|
Mediastinal, Infiltration Cellular, | | |
Plasma Cell | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + M | 44 |
Congestion | | 1 2.0|
Infiltration Cellular, Plasma Cell | 2 2 2 4 3 | 28 2.5|
Lymphatic, Angiectasis | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + | 50 |
Congestion | 3 2 | 4 3.3|
Granuloma | 2 2 | 27 2.1|
Infiltration Cellular, Plasma Cell | | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + | 50 |
Granuloma | | 3 3.0|
Hematopoietic Cell Proliferation | 4 | 19 2.2|
Infarct | | 1 4.0|
Pigmentation, Hemosiderin | 2 3 2 4 | 19 2.3|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + M | 42 |
Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + M M | 43 |
Ectasia | 4 | 3 3.0|
Galactocele | X | 8 |
Hypertrophy | | 1 2.0|
Inflammation, Acute | 4 | 1 4.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + | 48 |
Cyst Epithelial Inclusion | | 1 |
Hemorrhage, Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + | 50 |
Hyperostosis | X X | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 6| 6| 5| 5| 3| 3| | |
DAY ON TEST | 3| 3| 6| 2| 6| 9| 8| 5| 5| 0| | |
| 0| 0| 4| 9| 8| 0| 5| 4| 4| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
0.6% HF | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + | 50 |
Hemorrhage | | 1 3.0|
Hydrocephalus | | 6 2.2|
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
Degeneration | | 1 2.0|
__________________________________________________________________________|____________|
Spinal Cord | | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + | 50 |
Congestion | | 1 1.0|
Alveolar Epithelium, Metaplasia | | 1 2.0|
Peribronchial, Inflammation, Chronic | 2 2 2 | 22 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + | 50 |
Fungus | | 2 3.0|
Inflammation, Acute | | 4 2.3|
Inflammation, Chronic | 1 | 14 1.9|
Metaplasia, Squamous | 2 2 3 2 | 14 2.1|
Respiratory Epithelium, Degeneration,| | |
Hyaline | | 4 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 2 |
__________________________________________________________________________|____________|
Eye | | 9 |
Lens, Degeneration | | 2 2.0|
Retina, Degeneration | | 3 3.7|
__________________________________________________________________________|____________|
Harderian Gland | | 5 |
Pigmentation | | 5 2.8|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + | 50 |
Calculus Gross Observation | X | 1 |
Cyst | | 1 |
Inflammation, Chronic | 3 | 1 3.0|
Nephropathy | 1 3 1 4 2 2 1 | 43 2.0|
Pelvis, Transitional Epithelium, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 6| 6| 5| 5| 3| 3| | |
DAY ON TEST | 3| 3| 6| 2| 6| 9| 8| 5| 5| 0| | |
| 0| 0| 4| 9| 8| 0| 5| 4| 4| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
0.6% HF | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Hyperplasia | 3 | 2 3.0|
Renal Tubule, Hyperplasia | | 1 1.0|
Renal Tubule, Pigmentation | | 3 1.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + | 50 |
Calculus Gross Observation | X | 1 |
Inflammation, Chronic | | 1 2.0|
Transitional Epithelium, Hyperplasia,| | |
Diffuse | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
_____________________________________________________________________________________________________________________
| 7| 4| 6| 5| 5| 7| 7| 6| 6| 4| 7| 4| 4| 7| 6| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 6| 6| 7| 6| 3| 3| 6| 5| 6| 3| 6| 6| 3| 3| 3| 3| 3| 7| 8| 3| 3| 3| 1| 0|
| 8| 4| 1| 9| 8| 6| 6| 1| 2| 4| 8| 4| 5| 8| 5| 8| 8| 6| 0| 2| 8| 8| 6| 2| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 |
Ulcer | 4 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + M + + + + + +|
Parasite Metazoan | 2 3 4 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 2 2 3 2|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X |
Clear Cell Focus | X |
Cytoplasmic Alteration, Focal | |
Fatty Change | 4 1 3 2 2 |
Granuloma | 2 |
Hemorrhage, Focal | |
Hepatodiaphragmatic Nodule | X X |
Hyperplasia, Focal | 2 2|
Hyperplasia, Multifocal | |
Necrosis, Focal | 1 |
Bile Duct, Hyperplasia | 2 2 2 3 2 2 2 2 4 2 2 3 2 3 2 2 2 2|
Subserosa, Thrombosis | X |
__________________________________________________________________________|
Mesentery | + |
Accessory Spleen | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Focal | 3 2 3 4 2 3 2 2 3 2 2 |
Artery, Inflammation, Chronic | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + +|
Karyomegaly | 2 2 2 2 2 2 3 2 3 3 2 2 2 2 2 3 2 2 2 2|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Hyperplasia, Basal Cell | 1 |
Inflammation, Chronic | |
Ulcer | |
Serosa, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
_____________________________________________________________________________________________________________________
| 7| 4| 6| 5| 5| 7| 7| 6| 6| 4| 7| 4| 4| 7| 6| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 6| 6| 7| 6| 3| 3| 6| 5| 6| 3| 6| 6| 3| 3| 3| 3| 3| 7| 8| 3| 3| 3| 1| 0|
| 8| 4| 1| 9| 8| 6| 6| 1| 2| 4| 8| 4| 5| 8| 5| 8| 8| 6| 0| 2| 8| 8| 6| 2| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic | |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 2 2 3 2 2 3 3 2 2 3 3 2 2 2 2 |
Atrium, Inflammation, Chronic | 2 |
Atrium, Thrombosis | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration, Focal | 2 3|
Necrosis, Focal | |
Vacuolization Cytoplasmic | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + M + + + + I +|
Hyperplasia, Focal | 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + M + + + + M I|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia, Focal | 2 2 2 2 3 3 2 3 2 2 2 4 2 |
Pars Distalis, Pigmentation, | |
Hemosiderin | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 4 2 1 3 2 2 4|
Follicle, Cyst | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Cyst | X|
Ectasia | 3 |
Inflammation, Acute | 3 |
Inflammation, Chronic | 1 2 1 1 1 1 2 2 2 1 1 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + M + + +|
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
_____________________________________________________________________________________________________________________
| 7| 4| 6| 5| 5| 7| 7| 6| 6| 4| 7| 4| 4| 7| 6| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 6| 6| 7| 6| 3| 3| 6| 5| 6| 3| 6| 6| 3| 3| 3| 3| 3| 7| 8| 3| 3| 3| 1| 0|
| 8| 4| 1| 9| 8| 6| 6| 1| 2| 4| 8| 4| 5| 8| 5| 8| 8| 6| 0| 2| 8| 8| 6| 2| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Atrophy | 3 2 3 3 2 3 3 4 |
Hyperplasia, Focal | |
Inflammation, Acute | 3 1 3 2|
Inflammation, Chronic | 2 |
Metaplasia, Squamous | 2|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + M + + +|
Atrophy | 3 4 3 3 4 3 3 4 4 3 3 4 4 4 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 2 |
Seminiferous Tubule, Atrophy | 3 3 4 3 3 3 4 1 4 3 4 3 3 3 4 3 |
Seminiferous Tubule, Hypospermia | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + I + + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 2 3 3 2 2 2|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Congestion | |
Mediastinal, Infiltration Cellular, | |
Plasma Cell | 3 |
Mediastinal, Lymphatic, Angiectasis | |
Pancreatic, Congestion | 2 |
Pancreatic, Lymphatic, Angiectasis | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + M + + + + + + +|
Infiltration Cellular, Plasma Cell | 3 4 4 4 3 3 4 4 3 3 4 2 2 2 2 3|
Lymphatic, Angiectasis | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 2 |
Granuloma | 2 2 2 2 1 2 2 2 2 2 2|
Lymphatic, Angiectasis | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 3 |
Fibrosis, Focal | 2 |
Granuloma | |
Hematopoietic Cell Proliferation | 2 3 2 2 2 2|
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Thymus | + + + + M + + + M + + M + + + + + M + + +|
Atrophy | 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M + + + + M + M M M M + + + + M +|
Ectasia | 4 |
Galactocele | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
_____________________________________________________________________________________________________________________
| 7| 4| 6| 5| 5| 7| 7| 6| 6| 4| 7| 4| 4| 7| 6| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 6| 6| 7| 6| 3| 3| 6| 5| 6| 3| 6| 6| 3| 3| 3| 3| 3| 7| 8| 3| 3| 3| 1| 0|
| 8| 4| 1| 9| 8| 6| 6| 1| 2| 4| 8| 4| 5| 8| 5| 8| 8| 6| 0| 2| 8| 8| 6| 2| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Acanthosis | 4 |
Hyperkeratosis | 4 |
Hyperplasia, Basal Cell | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | 2 |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Alveolar Epithelium, Metaplasia | |
Peribronchial, Inflammation, Chronic | 2 2 2 2 2 1 2 2 2 2 2 2|
Pleura, Fibrosis | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + +|
Fungus | 4 X |
Hemorrhage | 3 4 |
Inflammation, Acute | 3 3 |
Inflammation, Chronic | 2 2 1 2 2 2 1 2 2 2 |
Metaplasia, Squamous | 2 2 2 2 2 2 3 2 2 2 2 3 2 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
Lens, Degeneration | |
__________________________________________________________________________|
Harderian Gland | + |
Pigmentation | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 3 |
Nephropathy | 2 2 2 2 4 3 3 2 2 3 2 2 4 2 3 2 3 2 3 1 2|
Renal Tubule, Cyst | X |
Renal Tubule, Hyperplasia | 2 |
Renal Tubule, Pigmentation | 2 3 |
Transitional Epithelium, Hyperplasia,| |
Focal | |
Transitional Epithelium, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 6| 4| 7| 7| 6| 6| 6| 7| 7| 7| 6| 5| 7| 7| 4| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 4| 6| 3| 3| 3| 3| 1| 3| 3| 1| 4| 6| 3| 3| 6| 3| 3|
| 6| 6| 6| 1| 4| 8| 8| 8| 0| 4| 6| 6| 2| 2| 2| 8| 7| 8| 1| 8| 8| 8| 4| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + M + + + + + + + + + + + +|
Parasite Metazoan | 2 4 3 3 3 |
Ulcer | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + M + + + + + + + + + + + + + +|
Parasite Metazoan | 4 2 3 3 2 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 4 4 3 3 4 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X |
Clear Cell Focus | |
Cytoplasmic Alteration, Focal | 2 |
Fatty Change | 3 2 2 |
Granuloma | 1 |
Hemorrhage, Focal | 3 |
Hepatodiaphragmatic Nodule | X |
Hyperplasia, Focal | 1 |
Hyperplasia, Multifocal | 3 |
Necrosis, Focal | 2 2 |
Bile Duct, Hyperplasia | 2 2 2 1 2 2 1 2 3 3 3 2 3 2 3 2 3 2 2 2|
Subserosa, Thrombosis | |
__________________________________________________________________________|
Mesentery | + |
Accessory Spleen | X |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Focal | 1 4 4 2 2 1 2 2 2 2 4 2|
Artery, Inflammation, Chronic | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + +|
Karyomegaly | 2 1 2 2 3 3 3 3 2 3 2 2 3 2 2 2 2 3 2 2 3 2|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + M + + + + + + + + + + + + +|
Acanthosis | 2 2 |
Hyperplasia, Basal Cell | 2 |
Inflammation, Chronic | 2|
Ulcer | 3 3 |
Serosa, Inflammation, Chronic | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 6| 4| 7| 7| 6| 6| 6| 7| 7| 7| 6| 5| 7| 7| 4| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 4| 6| 3| 3| 3| 3| 1| 3| 3| 1| 4| 6| 3| 3| 6| 3| 3|
| 6| 6| 6| 1| 4| 8| 8| 8| 0| 4| 6| 6| 2| 2| 2| 8| 7| 8| 1| 8| 8| 8| 4| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 4 2 1 2 3 2 1 2 3 3 2 2 3 1 3 3 3|
Atrium, Inflammation, Chronic | |
Atrium, Thrombosis | X 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration, Focal | 3 |
Necrosis, Focal | 2 2 |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + I + + M M I + + + + + + + + + + + +|
Hyperplasia, Focal | 1 3 2 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + + + + I + + + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia, Focal | 1 3 3 4 3 |
Pars Distalis, Pigmentation, | |
Hemosiderin | 2 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 4 3 1 1 4 4 |
Follicle, Cyst | X|
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + M + + + + + + +|
Abscess | 2 2 1 |
Cyst | |
Ectasia | |
Inflammation, Acute | 2 |
Inflammation, Chronic | 2 1 1 1 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + M + + + M + + +|
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 6| 4| 7| 7| 6| 6| 6| 7| 7| 7| 6| 5| 7| 7| 4| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 4| 6| 3| 3| 3| 3| 1| 3| 3| 1| 4| 6| 3| 3| 6| 3| 3|
| 6| 6| 6| 1| 4| 8| 8| 8| 0| 4| 6| 6| 2| 2| 2| 8| 7| 8| 1| 8| 8| 8| 4| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Atrophy | 3 4 4 4|
Hyperplasia, Focal | |
Inflammation, Acute | 4 |
Inflammation, Chronic | 2 1 2 2 2 1 |
Metaplasia, Squamous | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + M + + + + + + +|
Atrophy | 4 4 4 4 3 4 3 4 3 2 4 4 4 4|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | |
Seminiferous Tubule, Atrophy | 3 3 3 3 3 3 3 3 3 3 3 3 3 4 3 3 3|
Seminiferous Tubule, Hypospermia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + + +|
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 2 3 3 3 3 3 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Congestion | 2 |
Mediastinal, Infiltration Cellular, | |
Plasma Cell | |
Mediastinal, Lymphatic, Angiectasis | 2 |
Pancreatic, Congestion | |
Pancreatic, Lymphatic, Angiectasis | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + + + + + + + + + + + M + + + + + +|
Infiltration Cellular, Plasma Cell | 3 3 2 4 2 2 3 2 4 2 2 4 4 4|
Lymphatic, Angiectasis | 2 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Granuloma | 2 2 2 2 2 2 2 2 3 2 2|
Lymphatic, Angiectasis | 4 2 3 2 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Fibrosis, Focal | 3 |
Granuloma | 2 |
Hematopoietic Cell Proliferation | 3 2 2 1 1 |
Pigmentation, Hemosiderin | 2 2 3 2 |
__________________________________________________________________________|
Thymus | + + + + + + + M + + + + M M + + + + M + M + +|
Atrophy | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + M + + + M + + + + + + M + + M + M M|
Ectasia | 2 3 3 |
Galactocele | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 6| 4| 7| 7| 6| 6| 6| 7| 7| 7| 6| 5| 7| 7| 4| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 4| 6| 3| 3| 3| 3| 1| 3| 3| 1| 4| 6| 3| 3| 6| 3| 3|
| 6| 6| 6| 1| 4| 8| 8| 8| 0| 4| 6| 6| 2| 2| 2| 8| 7| 8| 1| 8| 8| 8| 4| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Acanthosis | |
Hyperkeratosis | |
Hyperplasia, Basal Cell | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | 2 2 2 2 |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Alveolar Epithelium, Metaplasia | 2 |
Peribronchial, Inflammation, Chronic | 2 2 2 1 2 2 2 2 2 2|
Pleura, Fibrosis | |
__________________________________________________________________________|
Nose | + + + + + + + + + M + + + + + + + + + + + + +|
Fungus | X X 2 X |
Hemorrhage | |
Inflammation, Acute | 3 3 |
Inflammation, Chronic | 3 3 2 3 2 2 2 1 |
Metaplasia, Squamous | 3 2 2 3 2 2 2 2 2 2 2 3 2 2 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + + |
__________________________________________________________________________|
Eye | + + |
Lens, Degeneration | 3 |
__________________________________________________________________________|
Harderian Gland | + + |
Pigmentation | 3 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | |
Nephropathy | 3 2 2 1 1 2 2 4 3 2 2 2 2 2 3 2 3 1 1 2 3 2 4|
Renal Tubule, Cyst | X |
Renal Tubule, Hyperplasia | |
Renal Tubule, Pigmentation | 2 |
Transitional Epithelium, Hyperplasia,| |
Focal | 2 2|
Transitional Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + M + + + + + + +|
Artery, Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 4| 7| 4| 7| 6| 4| 4| | |
DAY ON TEST | 6| 3| 3| 6| 0| 6| 1| 8| 6| 6| | |
| 4| 6| 6| 5| 3| 4| 4| 2| 5| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + A + | 48 |
Parasite Metazoan | | 6 2.8|
Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + | 48 |
Parasite Metazoan | | 9 2.8|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + | 50 |
Parasite Metazoan | 2 | 12 2.8|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + | 50 |
Artery, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | M + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + | 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + | 50 |
Basophilic Focus | X | 6 |
Clear Cell Focus | | 1 |
Cytoplasmic Alteration, Focal | | 1 2.0|
Fatty Change | 2 | 9 2.3|
Granuloma | | 2 1.5|
Hemorrhage, Focal | | 1 3.0|
Hepatodiaphragmatic Nodule | | 3 |
Hyperplasia, Focal | | 3 1.7|
Hyperplasia, Multifocal | | 1 3.0|
Necrosis, Focal | | 3 1.7|
Bile Duct, Hyperplasia | 2 2 3 2 | 42 2.2|
Subserosa, Thrombosis | | 1 |
__________________________________________________________________________|____________|
Mesentery | + | 3 |
Accessory Spleen | | 1 |
Fat, Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + M + + + + | 49 |
Acinus, Atrophy, Focal | 3 1 2 | 26 2.4|
Artery, Inflammation, Chronic | | 2 3.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + | 50 |
Karyomegaly | 2 2 2 | 45 2.2|
__________________________________________________________________________|____________|
Stomach | + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + | 49 |
Acanthosis | | 2 2.0|
Hyperplasia, Basal Cell | 2 | 3 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 4| 7| 4| 7| 6| 4| 4| | |
DAY ON TEST | 6| 3| 3| 6| 0| 6| 1| 8| 6| 6| | |
| 4| 6| 6| 5| 3| 4| 4| 2| 5| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Chronic | | 1 2.0|
Ulcer | 2 3 | 4 2.8|
Serosa, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + | 50 |
Hyperplasia, Lymphoid | | 1 2.0|
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + | 50 |
Cardiomyopathy | 4 2 2 3 3 3 | 40 2.5|
Atrium, Inflammation, Chronic | | 1 2.0|
Atrium, Thrombosis | | 4 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + | 50 |
Cytoplasmic Alteration, Focal | 2 | 4 2.5|
Necrosis, Focal | | 2 2.0|
Vacuolization Cytoplasmic | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + | 44 |
Hyperplasia, Focal | 3 | 8 2.1|
__________________________________________________________________________|____________|
Islets, Pancreatic | + M + + + + | 49 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | I + + + M + | 42 |
__________________________________________________________________________|____________|
Pituitary Gland | + + I + + M | 48 |
Pars Distalis, Angiectasis | | 1 3.0|
Pars Distalis, Cyst | | 2 |
Pars Distalis, Hyperplasia, Focal | | 18 2.5|
Pars Distalis, Pigmentation, | | |
Hemosiderin | | 2 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + | 50 |
C-Cell, Hyperplasia | | 15 2.6|
Follicle, Cyst | | 1 |
Follicular Cell, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 4| 7| 4| 7| 6| 4| 4| | |
DAY ON TEST | 6| 3| 3| 6| 0| 6| 1| 8| 6| 6| | |
| 4| 6| 6| 5| 3| 4| 4| 2| 5| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 1 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + | 50 |
__________________________________________________________________________|____________|
Preputial Gland | + M + + + + | 48 |
Abscess | | 3 1.7|
Cyst | X | 2 |
Ectasia | | 1 3.0|
Inflammation, Acute | | 2 2.5|
Inflammation, Chronic | 2 | 17 1.4|
__________________________________________________________________________|____________|
Prostate | + + + + + + | 47 |
Atrophy | 3 | 13 3.2|
Hyperplasia, Focal | 2 | 1 2.0|
Inflammation, Acute | 3 | 6 2.7|
Inflammation, Chronic | | 7 1.7|
Metaplasia, Squamous | | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + | 48 |
Atrophy | 4 4 | 30 3.6|
__________________________________________________________________________|____________|
Testes | + + + + + + | 50 |
Interstitial Cell, Hyperplasia | | 1 2.0|
Seminiferous Tubule, Atrophy | 3 3 3 3 | 37 3.1|
Seminiferous Tubule, Hypospermia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + | 25 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + | 50 |
Hyperplasia | 3 3 | 19 2.6|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + | 50 |
Mediastinal, Congestion | | 1 2.0|
Mediastinal, Infiltration Cellular, | | |
Plasma Cell | | 1 3.0|
Mediastinal, Lymphatic, Angiectasis | | 1 2.0|
Pancreatic, Congestion | | 1 2.0|
Pancreatic, Lymphatic, Angiectasis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + | 47 |
Infiltration Cellular, Plasma Cell | 3 4 2 2 | 34 3.0|
Lymphatic, Angiectasis | 3 | 3 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + M + + | 49 |
Congestion | 2 | 3 2.3|
Granuloma | 2 | 23 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 64
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 4| 7| 4| 7| 6| 4| 4| | |
DAY ON TEST | 6| 3| 3| 6| 0| 6| 1| 8| 6| 6| | |
| 4| 6| 6| 5| 3| 4| 4| 2| 5| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lymphatic, Angiectasis | 4 | 7 2.9|
__________________________________________________________________________|____________|
Spleen | + + + + + + | 50 |
Congestion | | 2 3.0|
Fibrosis, Focal | | 2 2.5|
Granuloma | | 1 2.0|
Hematopoietic Cell Proliferation | | 11 2.0|
Pigmentation, Hemosiderin | | 4 2.3|
__________________________________________________________________________|____________|
Thymus | + + + M + + | 40 |
Atrophy | | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M + + + + | 36 |
Ectasia | 4 | 5 3.2|
Galactocele | X X | 3 |
__________________________________________________________________________|____________|
Skin | + + + + + + | 50 |
Acanthosis | | 1 4.0|
Hyperkeratosis | | 1 4.0|
Hyperplasia, Basal Cell | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + | 49 |
Hydrocephalus | 2 | 6 2.0|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + | 50 |
Congestion | 3 | 1 3.0|
Alveolar Epithelium, Metaplasia | | 1 2.0|
Peribronchial, Inflammation, Chronic | 2 3 2 | 25 2.0|
Pleura, Fibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + | 49 |
Fungus | | 6 3.0|
Hemorrhage | | 2 3.5|
Inflammation, Acute | | 4 3.0|
Inflammation, Chronic | 2 2 | 20 2.0|
Metaplasia, Squamous | 1 2 2 2 4 | 35 2.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 65
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 4| 7| 4| 7| 6| 4| 4| | |
DAY ON TEST | 6| 3| 3| 6| 0| 6| 1| 8| 6| 6| | |
| 4| 6| 6| 5| 3| 4| 4| 2| 5| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Trachea | + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 3 |
__________________________________________________________________________|____________|
Eye | | 3 |
Lens, Degeneration | | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 4 |
Pigmentation | 3 | 4 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + | 50 |
Atrophy, Focal | | 1 3.0|
Nephropathy | 2 3 2 2 3 1 | 50 2.3|
Renal Tubule, Cyst | | 2 |
Renal Tubule, Hyperplasia | | 1 2.0|
Renal Tubule, Pigmentation | | 3 2.3|
Transitional Epithelium, Hyperplasia,| | |
Focal | | 2 2.0|
Transitional Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + | 49 |
Artery, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 66
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
_____________________________________________________________________________________________________________________
| 4| 7| 7| 4| 7| 7| 7| 6| 4| 4| 7| 7| 6| 6| 6| 7| 7| 4| 6| 5| 7| 7| 7| 7| 6|
DAY ON TEST | 6| 3| 3| 6| 2| 3| 3| 8| 6| 6| 3| 3| 1| 1| 0| 3| 2| 6| 5| 8| 3| 3| 3| 3| 3|
| 5| 2| 2| 5| 5| 5| 3| 7| 4| 5| 5| 5| 9| 3| 3| 5| 3| 5| 2| 5| 7| 7| 7| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.06% LM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + M + + + + + + + + + + +|
Parasite Metazoan | 4 2 2 |
Ulcer | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + M + + + + + + + + + +|
Parasite Metazoan | 3 4 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 4 4 2 3 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + +|
Muscularis, Hypertrophy | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Basophilic Focus | |
Congestion | |
Fatty Change | 2 4 2 1|
Granuloma | |
Hepatodiaphragmatic Nodule | X X X X |
Hyperplasia, Focal | |
Necrosis, Focal | 1 1 4 |
Bile Duct, Hyperplasia | 3 2 3 4 3 3 2 2 3 2 2 2 2 2 2 2|
__________________________________________________________________________|
Mesentery | + + |
Fibrosis | 4 |
Inflammation, Acute | 3 |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Pigmentation, Focal, Hemosiderin | |
Acinus, Atrophy, Focal | 2 2 3 3 4 2 3 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
Karyomegaly | 3 2 3 3 3 2 2 3 3 2 2 3 3 2 3 2|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 |
Hyperkeratosis | |
Perforation | |
Ulcer | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
Mineralization | 1 |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
_____________________________________________________________________________________________________________________
| 4| 7| 7| 4| 7| 7| 7| 6| 4| 4| 7| 7| 6| 6| 6| 7| 7| 4| 6| 5| 7| 7| 7| 7| 6|
DAY ON TEST | 6| 3| 3| 6| 2| 3| 3| 8| 6| 6| 3| 3| 1| 1| 0| 3| 2| 6| 5| 8| 3| 3| 3| 3| 3|
| 5| 2| 2| 5| 5| 5| 3| 7| 4| 5| 5| 5| 9| 3| 3| 5| 3| 5| 2| 5| 7| 7| 7| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.06% LM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 3 3 3 2 3 3 2 2 3 4 3 2 3 3 3 3 2 2|
Atrium, Inflammation, Chronic | |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration, Focal | 2 4 2 |
Hyperplasia, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 2 |
Necrosis, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2|
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + + + + + + + + + + + + M|
Hyperplasia | 3 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + M + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia, Focal | 2 2 2 2 4 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 2 4 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Cyst | X |
Inflammation, Acute | 2 |
Inflammation, Chronic | 1 1 1 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 2 2 3 3 3 2 |
Inflammation, Acute | 2 2 1|
Inflammation, Chronic | 2 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 3 4 4 3 4 4 3 3 4 2 4 4 3|
Inflammation, Acute | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
_____________________________________________________________________________________________________________________
| 4| 7| 7| 4| 7| 7| 7| 6| 4| 4| 7| 7| 6| 6| 6| 7| 7| 4| 6| 5| 7| 7| 7| 7| 6|
DAY ON TEST | 6| 3| 3| 6| 2| 3| 3| 8| 6| 6| 3| 3| 1| 1| 0| 3| 2| 6| 5| 8| 3| 3| 3| 3| 3|
| 5| 2| 2| 5| 5| 5| 3| 7| 4| 5| 5| 5| 9| 3| 3| 5| 3| 5| 2| 5| 7| 7| 7| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.06% LM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Artery, Inflammation | |
Interstitial Cell, Hyperplasia | 3 |
Seminiferous Tubule, Atrophy | 3 4 4 3 4 4 3 3 3 3 4 3 3 3|
Seminiferous Tubule, Hypospermia | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 3 3 2 2 |
Myelofibrosis | 4 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Congestion | |
Mediastinal, Infiltration Cellular, | |
Plasma Cell | |
Pancreatic, Infiltration Cellular, | |
Plasma Cell | |
Renal, Congestion | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M + + + + + + + + + + + + +|
Congestion | 4 |
Infiltration Cellular, Plasma Cell | 3 3 3 4 3 3 4 2 4 3 4 4 3 2 2 3|
Lymphatic, Angiectasis | 2 3 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Granuloma | 1 2 2 2 2 2 2 2 2 2 2 2 |
Lymphatic, Angiectasis | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | |
Hematopoietic Cell Proliferation | 2 2 2 4 2 2|
Pigmentation, Hemosiderin | 2 3 2 2 2|
__________________________________________________________________________|
Thymus | + + + + M + + M M M + + + + + + + + M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + + + + + + + + + M + M + M M +|
Abscess | |
Ectasia | 3 4 4 |
Galactocele | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Basal Cell | |
Dermis, Fibrosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
_____________________________________________________________________________________________________________________
| 4| 7| 7| 4| 7| 7| 7| 6| 4| 4| 7| 7| 6| 6| 6| 7| 7| 4| 6| 5| 7| 7| 7| 7| 6|
DAY ON TEST | 6| 3| 3| 6| 2| 3| 3| 8| 6| 6| 3| 3| 1| 1| 0| 3| 2| 6| 5| 8| 3| 3| 3| 3| 3|
| 5| 2| 2| 5| 5| 5| 3| 7| 4| 5| 5| 5| 9| 3| 3| 5| 3| 5| 2| 5| 7| 7| 7| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.06% LM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | 2 3|
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Fungus | |
Granuloma | |
Inflammation, Focal, Subacute | 2 |
Alveolar Epithelium, Metaplasia | 4 |
Peribronchial, Inflammation, Chronic | 2 2 2 2 2 2 2 3 2 2 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Fungus | X |
Inflammation, Acute | 3 2|
Inflammation, Chronic | 2 2 2 2 2 3 2 2 |
Metaplasia, Squamous | 2 2 4 2 2 2 4 2 2 2 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | |
Pigmentation | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | 4 |
Nephropathy | 2 3 3 3 2 2 3 3 2 3 2 3 4 3 1 3 3 4 2 2|
Renal Tubule, Cyst | X |
Renal Tubule, Hyperplasia | 2 |
Renal Tubule, Necrosis, Focal | 2 |
Renal Tubule, Pigmentation | 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + A + + + + + +|
Concretion | 4 |
Inflammation, Chronic | 1 1 |
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
_____________________________________________________________________________________________________________________
| 7| 4| 6| 6| 4| 7| 7| 6| 6| 5| 7| 7| 7| 7| 5| 7| 7| 6| 4| 4| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 6| 9| 7| 6| 3| 3| 8| 6| 0| 3| 3| 1| 1| 7| 3| 3| 7| 6| 6| 3| 3| 3| 0| 4|
| 7| 5| 2| 1| 4| 7| 7| 7| 9| 6| 8| 8| 8| 5| 9| 5| 5| 0| 4| 4| 2| 2| 2| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.06% LM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 |
Ulcer | 4 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 3 2 2 4 |
__________________________________________________________________________|
Intestine Large, Rectum | + + A + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 4 2|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + +|
Muscularis, Hypertrophy | |
__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Basophilic Focus | X X |
Congestion | 4 |
Fatty Change | 3 2 |
Granuloma | 2 |
Hepatodiaphragmatic Nodule | X |
Hyperplasia, Focal | 2 |
Necrosis, Focal | 1 |
Bile Duct, Hyperplasia | 4 2 2 3 2 2 1 2 2 2 2 1 2 2 4 2 3 2 3 3|
__________________________________________________________________________|
Mesentery | + + + + |
Fibrosis | |
Inflammation, Acute | |
Fat, Necrosis | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + M + + + + + + +|
Edema | |
Pigmentation, Focal, Hemosiderin | 3 |
Acinus, Atrophy, Focal | 4 2 3 3 2 4 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + +|
Karyomegaly | 2 2 2 2 2 2 2 2 2 2 3 3 3 2 2 3 2 2 3|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Hyperkeratosis | 3 |
Perforation | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Mineralization | |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
_____________________________________________________________________________________________________________________
| 7| 4| 6| 6| 4| 7| 7| 6| 6| 5| 7| 7| 7| 7| 5| 7| 7| 6| 4| 4| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 6| 9| 7| 6| 3| 3| 8| 6| 0| 3| 3| 1| 1| 7| 3| 3| 7| 6| 6| 3| 3| 3| 0| 4|
| 7| 5| 2| 1| 4| 7| 7| 7| 9| 6| 8| 8| 8| 5| 9| 5| 5| 0| 4| 4| 2| 2| 2| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.06% LM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 2 3 2 2 3 2 3 3 2 3 3 3 3 2|
Atrium, Inflammation, Chronic | 3 |
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration, Focal | 2 2 2 |
Hyperplasia, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + I + + + + +|
Hyperplasia, Focal | 2 2 3 1 2|
Necrosis, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + M + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + I + + + + + M + + M + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia, Focal | 2 1 1 2 2 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 4 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Cyst | |
Inflammation, Acute | |
Inflammation, Chronic | 2 2 1 2 1 2 1 2 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + M + + + + + + + + + + + +|
Atrophy | 2 2 3 2 3 3 3 3 |
Inflammation, Acute | 2 4 |
Inflammation, Chronic | 2 2 2|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + M + + + + + + + + + + + +|
Atrophy | 4 4 3 4 3 4 3 4 3 4 4 4 4 |
Inflammation, Acute | 4 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
_____________________________________________________________________________________________________________________
| 7| 4| 6| 6| 4| 7| 7| 6| 6| 5| 7| 7| 7| 7| 5| 7| 7| 6| 4| 4| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 6| 9| 7| 6| 3| 3| 8| 6| 0| 3| 3| 1| 1| 7| 3| 3| 7| 6| 6| 3| 3| 3| 0| 4|
| 7| 5| 2| 1| 4| 7| 7| 7| 9| 6| 8| 8| 8| 5| 9| 5| 5| 0| 4| 4| 2| 2| 2| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.06% LM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Artery, Inflammation | 4 |
Interstitial Cell, Hyperplasia | 3|
Seminiferous Tubule, Atrophy | 4 3 3 4 4 4 4 3 4 4 4 4 4 2 4 3 |
Seminiferous Tubule, Hypospermia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 2 4 3 2 3 2 3 3 3 3|
Myelofibrosis | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Congestion | 3 |
Mediastinal, Infiltration Cellular, | |
Plasma Cell | |
Pancreatic, Infiltration Cellular, | |
Plasma Cell | |
Renal, Congestion | 3|
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + + + + + + + + + + + M + +|
Congestion | |
Infiltration Cellular, Plasma Cell | 3 4 2 2 2 2 2 3 4 3 3 2 2 3 3|
Lymphatic, Angiectasis | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Granuloma | 2 3 2 2 2 3 2 3 2 2 2 2 |
Lymphatic, Angiectasis | 3 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | 2 2 1 |
Hematopoietic Cell Proliferation | 1 3 4 2 |
Pigmentation, Hemosiderin | 2 2 |
__________________________________________________________________________|
Thymus | M + M M + + + + + M + M + + + + + M + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + M M M + M + + + + + + + + + + M + +|
Abscess | 3 |
Ectasia | 4 4 |
Galactocele | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Basal Cell | |
Dermis, Fibrosis | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
_____________________________________________________________________________________________________________________
| 7| 4| 6| 6| 4| 7| 7| 6| 6| 5| 7| 7| 7| 7| 5| 7| 7| 6| 4| 4| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 6| 9| 7| 6| 3| 3| 8| 6| 0| 3| 3| 1| 1| 7| 3| 3| 7| 6| 6| 3| 3| 3| 0| 4|
| 7| 5| 2| 1| 4| 7| 7| 7| 9| 6| 8| 8| 8| 5| 9| 5| 5| 0| 4| 4| 2| 2| 2| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.06% LM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Fungus | X |
Granuloma | 2 |
Inflammation, Focal, Subacute | |
Alveolar Epithelium, Metaplasia | 3 2 |
Peribronchial, Inflammation, Chronic | 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Fungus | X X X |
Inflammation, Acute | 2 2 4 |
Inflammation, Chronic | 3 2 2 2 3 2 3 1 |
Metaplasia, Squamous | 3 2 2 3 2 2 3 3 3 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + + |
__________________________________________________________________________|
Harderian Gland | + + + |
Pigmentation | 3 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | |
Nephropathy | 3 2 2 2 2 1 3 1 3 3 4 4 3 2 3 2 1 3 4 2 1|
Renal Tubule, Cyst | X |
Renal Tubule, Hyperplasia | 2 2 2 |
Renal Tubule, Necrosis, Focal | |
Renal Tubule, Pigmentation | 3 2 2|
__________________________________________________________________________|
Urinary Bladder | + + A + + + + + + + + + + + + + + + + + +|
Concretion | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 6| 2| 3| 2| 3| 3| 3| 3| 3| | |
| 8| 4| 3| 8| 4| 2| 2| 2| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.06% LM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + | 49 |
Parasite Metazoan | 2 | 5 2.4|
Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + | 49 |
Parasite Metazoan | 2 | 8 2.8|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + M + M + + + + + | 47 |
Parasite Metazoan | 4 3 | 10 3.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + | 50 |
Muscularis, Hypertrophy | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + | 50 |
Angiectasis | | 2 2.0|
Basophilic Focus | | 2 |
Congestion | | 1 4.0|
Fatty Change | 3 | 7 2.4|
Granuloma | | 1 2.0|
Hepatodiaphragmatic Nodule | | 5 |
Hyperplasia, Focal | | 1 2.0|
Necrosis, Focal | 1 | 5 1.6|
Bile Duct, Hyperplasia | 3 2 3 2 2 2 2 2 | 44 2.3|
__________________________________________________________________________|____________|
Mesentery | + + + | 9 |
Fibrosis | | 1 4.0|
Inflammation, Acute | | 1 3.0|
Fat, Necrosis | 3 4 | 3 3.7|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + | 49 |
Edema | | 1 3.0|
Pigmentation, Focal, Hemosiderin | | 1 3.0|
Acinus, Atrophy, Focal | 2 2 | 17 2.7|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + | 50 |
Karyomegaly | 2 1 2 2 2 2 2 2 2 | 44 2.3|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + | 50 |
Acanthosis | | 1 3.0|
Hyperkeratosis | | 1 3.0|
Perforation | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 75
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 6| 2| 3| 2| 3| 3| 3| 3| 3| | |
| 8| 4| 3| 8| 4| 2| 2| 2| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.06% LM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Ulcer | 4 | 2 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + | 50 |
Hyperplasia, Lymphoid | | 1 3.0|
Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + | 50 |
Cardiomyopathy | 2 3 3 2 3 2 | 40 2.6|
Atrium, Inflammation, Chronic | | 1 3.0|
Atrium, Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + | 50 |
Cytoplasmic Alteration, Focal | | 6 2.3|
Hyperplasia, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + | 49 |
Hyperplasia, Focal | 1 2 | 9 1.9|
Necrosis, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + | 49 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + | 45 |
Hyperplasia | | 4 2.3|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + | 49 |
Pars Distalis, Cyst | | 4 |
Pars Distalis, Hyperplasia, Focal | 2 1 1 | 15 1.9|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + | 50 |
C-Cell, Hyperplasia | 4 1 1 4 | 12 2.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + | 50 |
Abscess | | 1 4.0|
Cyst | | 1 |
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 76
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 6| 2| 3| 2| 3| 3| 3| 3| 3| | |
| 8| 4| 3| 8| 4| 2| 2| 2| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.06% LM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Chronic | 2 1 1 | 15 1.5|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + | 49 |
Atrophy | 3 | 16 2.6|
Inflammation, Acute | 2 | 6 2.2|
Inflammation, Chronic | 2 | 6 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + | 49 |
Atrophy | 4 4 4 4 4 4 4 | 35 3.7|
Inflammation, Acute | | 1 4.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + | 50 |
Cyst | | 1 |
Artery, Inflammation | | 1 4.0|
Interstitial Cell, Hyperplasia | | 2 3.0|
Seminiferous Tubule, Atrophy | 4 3 4 4 4 4 | 36 3.6|
Seminiferous Tubule, Hypospermia | X X | 3 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + | 8 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + | 50 |
Hyperplasia | 3 3 | 20 2.8|
Myelofibrosis | 2 | 3 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + | 50 |
Mediastinal, Congestion | | 1 3.0|
Mediastinal, Infiltration Cellular, | | |
Plasma Cell | 3 | 1 3.0|
Pancreatic, Infiltration Cellular, | | |
Plasma Cell | 3 | 1 3.0|
Renal, Congestion | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + M + + + I | 45 |
Congestion | | 1 4.0|
Infiltration Cellular, Plasma Cell | 3 3 3 2 3 3 3 | 38 2.9|
Lymphatic, Angiectasis | 3 4 | 5 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + | 50 |
Congestion | | 1 2.0|
Granuloma | 2 3 2 3 3 3 | 30 2.2|
Lymphatic, Angiectasis | | 2 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + | 50 |
Fibrosis, Focal | | 3 1.7|
Hematopoietic Cell Proliferation | 1 2 2 | 13 2.2|
Pigmentation, Hemosiderin | 2 2 | 9 2.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 77
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 6| 2| 3| 2| 3| 3| 3| 3| 3| | |
| 8| 4| 3| 8| 4| 2| 2| 2| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.06% LM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thymus | + M + + + + M + + | 37 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M + M + M M M | 34 |
Abscess | | 1 3.0|
Ectasia | | 5 3.8|
Galactocele | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + | 50 |
Hyperplasia, Basal Cell | 2 | 1 2.0|
Dermis, Fibrosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + | 50 |
Hydrocephalus | 2 2 | 4 2.3|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + | 50 |
Congestion | | 1 2.0|
Fungus | | 1 |
Granuloma | 2 | 2 2.0|
Inflammation, Focal, Subacute | | 1 2.0|
Alveolar Epithelium, Metaplasia | | 3 3.0|
Peribronchial, Inflammation, Chronic | 2 2 | 20 2.1|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + | 50 |
Cyst | | 1 |
Fungus | | 4 |
Inflammation, Acute | | 5 2.6|
Inflammation, Chronic | 3 2 2 3 2 2 | 22 2.2|
Metaplasia, Squamous | 2 3 2 3 2 3 3 3 2 | 30 2.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 2 |
__________________________________________________________________________|____________|
Eye | + + | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 78
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 6| 2| 3| 2| 3| 3| 3| 3| 3| | |
| 8| 4| 3| 8| 4| 2| 2| 2| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.06% LM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + | 5 |
Pigmentation | 3 3 | 4 2.8|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + | 50 |
Mineralization, Focal | | 1 4.0|
Nephropathy | 2 4 3 2 2 2 3 4 2 | 50 2.6|
Renal Tubule, Cyst | | 2 |
Renal Tubule, Hyperplasia | 1 | 5 1.8|
Renal Tubule, Necrosis, Focal | | 1 2.0|
Renal Tubule, Pigmentation | | 5 2.2|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + | 48 |
Concretion | 4 | 2 4.0|
Inflammation, Chronic | | 2 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 79
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 4| 4| 7| 7| 4| 6| 4| 7| 6| 4| 6| 4|
DAY ON TEST | 6| 3| 1| 1| 2| 3| 3| 2| 0| 6| 3| 9| 3| 8| 6| 3| 3| 6| 4| 4| 1| 3| 6| 2| 6|
| 5| 1| 5| 0| 1| 1| 1| 5| 3| 1| 1| 2| 1| 4| 5| 1| 1| 5| 2| 1| 4| 8| 5| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.3% MM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + M + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + A + + + |
Parasite Metazoan | 3 4 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + |
Parasite Metazoan | 2 3 4 |
__________________________________________________________________________|
Intestine Large, Rectum | + + M + + + + + + + + + + + + + M + + + |
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + |
Muscularis, Hypertrophy | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + M + + + + + + + + A + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + |
Angiectasis | 4 |
Basophilic Focus | |
Congestion | |
Fatty Change | 3 1 2 |
Hepatodiaphragmatic Nodule | X |
Hyperplasia, Focal | |
Necrosis, Focal | 1 1 1 |
Bile Duct, Hyperplasia | 1 2 2 3 2 2 2 3 3 2 2 2 3 2 2 3 3 2 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + M + + + + + |
Congestion | |
Edema | |
Hemorrhage, Focal | 3 |
Acinus, Atrophy, Focal | 3 3 2 3 3 |
Artery, Hypertrophy | |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + |
Karyomegaly | 2 3 2 2 2 3 2 3 2 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + |
Acanthosis | 3 |
Hyperkeratosis | 3 |
Hyperplasia, Basal Cell | 3 2 |
Inflammation, Acute | 3 |
Perforation | |
Ulcer | 4 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + |
Mineralization | |
Ulcer | 2 |
_____________________________________________________________________________________________________________________|
Page 80
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 4| 4| 7| 7| 4| 6| 4| 7| 6| 4| 6| 4|
DAY ON TEST | 6| 3| 1| 1| 2| 3| 3| 2| 0| 6| 3| 9| 3| 8| 6| 3| 3| 6| 4| 4| 1| 3| 6| 2| 6|
| 5| 1| 5| 0| 1| 1| 1| 5| 3| 1| 1| 2| 1| 4| 5| 1| 1| 5| 2| 1| 4| 8| 5| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.3% MM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + |
Cardiomyopathy | 3 2 3 3 3 2 2 3 2 3 2 2 3 2 3 3 |
Dilatation | 4 |
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + |
Congestion | |
Cytoplasmic Alteration, Focal | 2 2 2 |
Vacuolization Cytoplasmic | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + I + + + + + + |
Hyperplasia, Focal | 2 2 2 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + M + + + M + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + M + M |
Hyperplasia | 2 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + M + + + |
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia, Focal | 4 2 4 3 2 3 |
Pars Distalis, Pigmentation, | |
Hemosiderin | 3 |
Pars Intermedia, Pigmentation, | |
Hemosiderin | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + |
C-Cell, Hyperplasia | 2 3 4 1 2 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Penis | + |
Concretion | 3 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + M + + + |
Abscess | 2 3 1 |
Hyperplasia | |
Inflammation, Acute | |
Inflammation, Chronic | 2 1 2 2 2 2 |
Inflammation, Subacute | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 81
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 4| 4| 7| 7| 4| 6| 4| 7| 6| 4| 6| 4|
DAY ON TEST | 6| 3| 1| 1| 2| 3| 3| 2| 0| 6| 3| 9| 3| 8| 6| 3| 3| 6| 4| 4| 1| 3| 6| 2| 6|
| 5| 1| 5| 0| 1| 1| 1| 5| 3| 1| 1| 2| 1| 4| 5| 1| 1| 5| 2| 1| 4| 8| 5| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.3% MM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Atrophy | 4 4 3 3 3 2 3 |
Inflammation, Acute | 4 |
Inflammation, Chronic | 2 2 |
Inflammation, Subacute | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + |
Atrophy | 4 4 4 3 4 4 4 3 4 2 2 1 |
Dilatation | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + |
Hemorrhage | |
Interstitial Cell, Hyperplasia | 3 |
Seminiferous Tubule, Atrophy | 4 4 4 3 2 4 4 4 4 3 3 3 4 |
Seminiferous Tubule, Hypospermia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 4 3 3 3 3 3 3 |
Myelofibrosis | 1 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + |
Mediastinal, Congestion | 3 |
Pancreatic, Congestion | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + M + |
Angiectasis | |
Congestion | 3 3 |
Infiltration Cellular, Plasma Cell | 2 2 3 4 4 4 4 3 2 4 1 2 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + |
Congestion | 3 3 2 3 |
Granuloma | 2 3 2 2 2 3 3 |
Lymphatic, Angiectasis | 3 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + |
Congestion | 4 |
Hematopoietic Cell Proliferation | 2 2 3 2 |
Pigmentation, Hemosiderin | 2 3 2 3 2 |
Thrombosis | X |
Capsule, Fibrosis, Focal | 3 |
__________________________________________________________________________|
Thymus | + M + + + + + + + + + + + + + + M + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + M + M + M M + + M |
Ectasia | 4 4 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + M + + + + |
Subcutaneous Tissue, Lymphatic, | |
Dilatation | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 82
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 4| 4| 7| 7| 4| 6| 4| 7| 6| 4| 6| 4|
DAY ON TEST | 6| 3| 1| 1| 2| 3| 3| 2| 0| 6| 3| 9| 3| 8| 6| 3| 3| 6| 4| 4| 1| 3| 6| 2| 6|
| 5| 1| 5| 0| 1| 1| 1| 5| 3| 1| 1| 2| 1| 4| 5| 1| 1| 5| 2| 1| 4| 8| 5| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.3% MM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + |
Hydrocephalus | 4 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + |
Congestion | 4 2 |
Hemorrhage, Focal | 4 |
Alveolar Epithelium, Metaplasia | 3 |
Peribronchial, Inflammation, Chronic | 2 2 2 2 3 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + |
Fibrosis | 2 |
Fungus | X |
Inflammation, Acute | 3 2 |
Inflammation, Chronic | 2 2 3 3 3 3 |
Metaplasia, Squamous | 2 2 2 2 2 2 2 3 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
Anterior Chamber, Fibrosis | |
__________________________________________________________________________|
Harderian Gland | + + + |
Inflammation, Chronic | 2 1 |
Pigmentation | 4 3 2 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + |
Cyst | |
Fibrosis, Focal | 2 |
Nephropathy | 2 4 3 2 4 3 4 2 3 3 2 3 1 3 2 1 1 1 3 2 |
Cortex, Necrosis, Focal | 2 |
Pelvis, Transitional Epithelium, | |
Hyperplasia | 2 |
Renal Tubule, Cyst | |
Renal Tubule, Hyperplasia | |
Renal Tubule, Pigmentation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + A + M + |
Concretion | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 83
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 4| 7| 4| 6| 6| 6| 4| 6| 5|
DAY ON TEST | 3| 0| 5| 6| 7| 6| 3| 3| 3| 2| 3| 3| 3| 1| 2| 3| 6| 3| 6| 4| 9| 7| 6| 2| 8|
| 1| 3| 5| 5| 8| 4| 2| 2| 2| 4| 3| 3| 3| 9| 7| 2| 5| 2| 5| 8| 8| 0| 5| 7| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.3% MM | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 4 3 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 3 4 2 4 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + +|
Muscularis, Hypertrophy | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X|
Congestion | |
Fatty Change | 1 1 3 2|
Hepatodiaphragmatic Nodule | X X|
Hyperplasia, Focal | |
Necrosis, Focal | 1 1 |
Bile Duct, Hyperplasia | 3 3 2 2 2 2 2 2 2 3 2 1 3 2 3 2|
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + M + + + + + + + + + + + + + + + + +|
Congestion | |
Edema | |
Hemorrhage, Focal | |
Acinus, Atrophy, Focal | 2 2 2 2 3 2 2|
Artery, Hypertrophy | |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
Karyomegaly | 2 3 3 3 3 2 2 2 2 2 3 3 3 2 3 1 2 2 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + M + + M + +|
Acanthosis | |
Hyperkeratosis | |
Hyperplasia, Basal Cell | 3 2 |
Inflammation, Acute | |
Perforation | X |
Ulcer | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
Ulcer | |
_____________________________________________________________________________________________________________________|
Page 84
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 4| 7| 4| 6| 6| 6| 4| 6| 5|
DAY ON TEST | 3| 0| 5| 6| 7| 6| 3| 3| 3| 2| 3| 3| 3| 1| 2| 3| 6| 3| 6| 4| 9| 7| 6| 2| 8|
| 1| 3| 5| 5| 8| 4| 2| 2| 2| 4| 3| 3| 3| 9| 7| 2| 5| 2| 5| 8| 8| 0| 5| 7| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.3% MM | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 2 2 2 2 2 1 2 2 3 3 3 2 1|
Dilatation | |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Cytoplasmic Alteration, Focal | 2 2 3 |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 3 2 3 |
__________________________________________________________________________|
Islets, Pancreatic | + M + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + M + + +|
Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia, Focal | 3 3 4 1 3 2 |
Pars Distalis, Pigmentation, | |
Hemosiderin | |
Pars Intermedia, Pigmentation, | |
Hemosiderin | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 2 4 2 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | +|
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | |
Concretion | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Hyperplasia | 2 |
Inflammation, Acute | |
Inflammation, Chronic | 1 2 2 2 1 2 2 |
Inflammation, Subacute | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 85
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 4| 7| 4| 6| 6| 6| 4| 6| 5|
DAY ON TEST | 3| 0| 5| 6| 7| 6| 3| 3| 3| 2| 3| 3| 3| 1| 2| 3| 6| 3| 6| 4| 9| 7| 6| 2| 8|
| 1| 3| 5| 5| 8| 4| 2| 2| 2| 4| 3| 3| 3| 9| 7| 2| 5| 2| 5| 8| 8| 0| 5| 7| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.3% MM | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Atrophy | 3 2 3 3 4 3 3 2 |
Inflammation, Acute | 2 2 4 2|
Inflammation, Chronic | 2 2 |
Inflammation, Subacute | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 4 4 4 4 4 4 3 4 3 4 4 |
Dilatation | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
Interstitial Cell, Hyperplasia | 2 4|
Seminiferous Tubule, Atrophy | 4 4 4 3 4 4 2 2 4 3 4 4 3 |
Seminiferous Tubule, Hypospermia | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 2 2 1 3 3 2 3 2 |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Congestion | |
Pancreatic, Congestion | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 |
Congestion | 3|
Infiltration Cellular, Plasma Cell | 2 2 4 4 4 2 2 4 4 4 2 3 2 4 2 2 2|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Granuloma | 2 3 2 2 2 2 2 2 2 2 2 2 |
Lymphatic, Angiectasis | 4 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hematopoietic Cell Proliferation | 2 1 2 3 3 2 |
Pigmentation, Hemosiderin | 2 4 |
Thrombosis | |
Capsule, Fibrosis, Focal | |
__________________________________________________________________________|
Thymus | + M M + + + + + + + + M + M + M + M + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M M + + + M M + M + + + M + + +|
Ectasia | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + M + + + + + + +|
Subcutaneous Tissue, Lymphatic, | |
Dilatation | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 86
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 4| 7| 4| 6| 6| 6| 4| 6| 5|
DAY ON TEST | 3| 0| 5| 6| 7| 6| 3| 3| 3| 2| 3| 3| 3| 1| 2| 3| 6| 3| 6| 4| 9| 7| 6| 2| 8|
| 1| 3| 5| 5| 8| 4| 2| 2| 2| 4| 3| 3| 3| 9| 7| 2| 5| 2| 5| 8| 8| 0| 5| 7| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.3% MM | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | 2 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hemorrhage, Focal | |
Alveolar Epithelium, Metaplasia | 2 |
Peribronchial, Inflammation, Chronic | 2 1 2 2 2 2 3|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Fungus | X X |
Inflammation, Acute | 3 2 3 |
Inflammation, Chronic | 2 2 2 2 1 2 1 |
Metaplasia, Squamous | 2 4 2 2 3 2 2 2 2 2 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + +|
Anterior Chamber, Fibrosis | |
__________________________________________________________________________|
Harderian Gland | + + + + +|
Inflammation, Chronic | |
Pigmentation | 2 4 2 2 2|
__________________________________________________________________________|
Zymbal's Gland | + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Fibrosis, Focal | |
Nephropathy | 3 3 2 1 4 3 3 2 4 3 3 3 1 4 4 4 1 3 3 2|
Cortex, Necrosis, Focal | |
Pelvis, Transitional Epithelium, | |
Hyperplasia | |
Renal Tubule, Cyst | |
Renal Tubule, Hyperplasia | 1 |
Renal Tubule, Pigmentation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + +|
Concretion | 2 |
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
Page 87
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 6| 5| | |
DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 3| 3| 6| | |
| 2| 2| 2| 2| 1| 2| 2| 2| 5| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.3% MM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + M + | 48 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 49 |
Parasite Metazoan | 3 | 7 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 50 |
Parasite Metazoan | 4 | 5 3.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + M + + | 47 |
Parasite Metazoan | 2 4 | 7 3.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 50 |
Muscularis, Hypertrophy | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 50 |
Angiectasis | | 1 4.0|
Basophilic Focus | | 1 |
Congestion | 2 1 | 2 1.5|
Fatty Change | 2 2 | 9 1.9|
Hepatodiaphragmatic Nodule | X X | 5 |
Hyperplasia, Focal | 3 | 1 3.0|
Necrosis, Focal | 3 | 6 1.3|
Bile Duct, Hyperplasia | 2 2 3 2 2 3 3 3 2 | 43 2.3|
__________________________________________________________________________|____________|
Mesentery | | 3 |
Fat, Necrosis | | 2 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 47 |
Congestion | 2 | 1 2.0|
Edema | 3 | 1 3.0|
Hemorrhage, Focal | | 1 3.0|
Acinus, Atrophy, Focal | 2 1 3 3 | 16 2.4|
Artery, Hypertrophy | 4 | 1 4.0|
__________________________________________________________________________|____________|
Pharynx | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 50 |
Karyomegaly | 2 2 2 2 3 3 3 3 2 | 46 2.3|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + M M + + + + + + | 46 |
Acanthosis | | 1 3.0|
Hyperkeratosis | | 1 3.0|
Hyperplasia, Basal Cell | | 4 2.5|
Inflammation, Acute | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 88
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 6| 5| | |
DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 3| 3| 6| | |
| 2| 2| 2| 2| 1| 2| 2| 2| 5| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.3% MM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Perforation | | 1 |
Ulcer | | 3 3.7|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 50 |
Mineralization | | 1 2.0|
Ulcer | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 50 |
Cardiomyopathy | 3 2 2 2 2 3 3 2 | 42 2.3|
Dilatation | | 1 4.0|
Atrium, Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 50 |
Congestion | | 1 2.0|
Cytoplasmic Alteration, Focal | 3 2 2 | 9 2.2|
Vacuolization Cytoplasmic | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 49 |
Hyperplasia, Focal | | 8 2.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + + + + | 46 |
Hyperplasia | 2 | 6 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 49 |
Pars Distalis, Angiectasis | 2 | 2 2.0|
Pars Distalis, Cyst | X | 1 |
Pars Distalis, Hyperplasia, Focal | 2 2 4 | 15 2.8|
Pars Distalis, Pigmentation, | | |
Hemosiderin | | 1 3.0|
Pars Intermedia, Pigmentation, | | |
Hemosiderin | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 50 |
C-Cell, Hyperplasia | 4 2 1 | 17 2.2|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 89
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 6| 5| | |
DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 3| 3| 6| | |
| 2| 2| 2| 2| 1| 2| 2| 2| 5| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.3% MM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Penis | | 1 |
Concretion | | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 49 |
Abscess | 4 4 | 5 2.8|
Hyperplasia | 1 | 2 1.5|
Inflammation, Acute | 2 | 1 2.0|
Inflammation, Chronic | | 13 1.8|
Inflammation, Subacute | | 1 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 50 |
Atrophy | 3 3 | 17 3.0|
Inflammation, Acute | | 5 2.8|
Inflammation, Chronic | 2 | 5 2.0|
Inflammation, Subacute | 3 | 1 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 50 |
Atrophy | 3 4 4 4 4 4 4 | 32 3.6|
Dilatation | | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 50 |
Hemorrhage | | 1 4.0|
Interstitial Cell, Hyperplasia | 3 3 | 5 3.0|
Seminiferous Tubule, Atrophy | 4 4 3 3 4 4 3 | 33 3.5|
Seminiferous Tubule, Hypospermia | 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 10 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 50 |
Hyperplasia | 3 2 2 | 20 2.6|
Myelofibrosis | | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 50 |
Mediastinal, Congestion | | 1 3.0|
Pancreatic, Congestion | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 49 |
Angiectasis | | 1 4.0|
Congestion | 2 | 4 2.8|
Infiltration Cellular, Plasma Cell | 4 3 2 4 4 4 2 2 | 38 2.9|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 50 |
Congestion | | 4 2.8|
Granuloma | 2 2 1 1 1 1 | 25 2.0|
Lymphatic, Angiectasis | 4 | 5 3.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 90
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 6| 5| | |
DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 3| 3| 6| | |
| 2| 2| 2| 2| 1| 2| 2| 2| 5| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.3% MM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 50 |
Congestion | | 1 4.0|
Hematopoietic Cell Proliferation | 2 2 2 2 2 | 15 2.1|
Pigmentation, Hemosiderin | 2 | 8 2.5|
Thrombosis | | 1 |
Capsule, Fibrosis, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + M + + M + + + + | 40 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M + M + M + + + M | 35 |
Ectasia | | 3 3.3|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 48 |
Subcutaneous Tissue, Lymphatic, | | |
Dilatation | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 50 |
Hydrocephalus | | 4 2.8|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 50 |
Congestion | | 3 2.7|
Hemorrhage, Focal | | 1 4.0|
Alveolar Epithelium, Metaplasia | 2 2 | 4 2.3|
Peribronchial, Inflammation, Chronic | 2 2 | 15 2.1|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 50 |
Fibrosis | | 1 2.0|
Fungus | | 3 |
Inflammation, Acute | 2 | 6 2.5|
Inflammation, Chronic | 2 1 2 3 | 17 2.1|
Metaplasia, Squamous | 2 2 2 2 3 2 2 3 2 | 30 2.2|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + | 11 |
Anterior Chamber, Fibrosis | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 91
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 6| 5| | |
DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 3| 3| 6| | |
| 2| 2| 2| 2| 1| 2| 2| 2| 5| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.3% MM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | I + | 9 |
Inflammation, Chronic | | 2 1.5|
Pigmentation | 3 | 9 2.7|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 50 |
Cyst | | 1 |
Fibrosis, Focal | | 1 2.0|
Nephropathy | 3 2 2 3 3 3 3 3 3 2 | 50 2.6|
Cortex, Necrosis, Focal | | 1 2.0|
Pelvis, Transitional Epithelium, | | |
Hyperplasia | | 1 2.0|
Renal Tubule, Cyst | X | 1 |
Renal Tubule, Hyperplasia | 1 2 | 3 1.3|
Renal Tubule, Pigmentation | 2 1 | 2 1.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + M | 47 |
Concretion | | 1 2.0|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 92
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 4| 4| 7| 6| 5| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 4| 7| 4| 6| 5|
DAY ON TEST | 6| 2| 2| 0| 6| 6| 2| 5| 9| 8| 2| 2| 2| 1| 9| 2| 2| 1| 0| 9| 6| 2| 6| 4| 7|
| 4| 9| 9| 4| 4| 5| 9| 7| 1| 5| 9| 9| 9| 9| 5| 9| 9| 8| 1| 5| 5| 9| 5| 3| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.6% HM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + + +|
Parasite Metazoan | 2 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 4 2 2 4 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + +|
Ulcer | 4|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 1 |
Clear Cell Focus | |
Congestion | 1 |
Eosinophilic Focus | 3 |
Fatty Change | 1 |
Hepatodiaphragmatic Nodule | X X |
Hyperplasia, Focal | |
Necrosis, Focal | |
Bile Duct, Hyperplasia | 2 2 2 2 3 2 2 1 2 2 2 2 2 3 1 2 3|
Centrilobular, Necrosis | 3 |
__________________________________________________________________________|
Mesentery | + + |
Edema | 3 |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + A + + + + + + + + + + + + + + +|
Ectopic Tissue | |
Acinus, Atrophy, Focal | 1 2 3 2 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
Karyomegaly | 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 |
Bulla | |
Hyperkeratosis | 1 |
Hyperplasia, Basal Cell | |
Inflammation, Chronic | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Mineralization | 2 |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
Page 93
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 4| 4| 7| 6| 5| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 4| 7| 4| 6| 5|
DAY ON TEST | 6| 2| 2| 0| 6| 6| 2| 5| 9| 8| 2| 2| 2| 1| 9| 2| 2| 1| 0| 9| 6| 2| 6| 4| 7|
| 4| 9| 9| 4| 4| 5| 9| 7| 1| 5| 9| 9| 9| 9| 5| 9| 9| 8| 1| 5| 5| 9| 5| 3| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.6% HM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 1 1 2 2 2 2 2 1 2 |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Cytoplasmic Alteration, Focal | 2 2|
Hemorrhage, Focal | 3 |
Vacuolization Cytoplasmic | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + M M + + + +|
Hyperplasia, Focal | 2 2 |
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + M + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + I + + + + + I + + + + M + + + +|
Hyperplasia | 2 4 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia, Focal | 4 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 4 |
Follicle, Cyst | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + +|
Degeneration, Focal | 3 |
__________________________________________________________________________|
Penis | |
Concretion | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + M + + +|
Abscess | |
Ectasia | |
Inflammation, Acute | |
Inflammation, Chronic | 1 2 1 1 2 2 2 1|
__________________________________________________________________________|
Prostate | + + + + + + + M + + + + + + + + + + + +|
Abscess | |
Atrophy | 4 4 3 |
Hyperplasia, Focal | 2 |
_____________________________________________________________________________________________________________________|
Page 94
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 4| 4| 7| 6| 5| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 4| 7| 4| 6| 5|
DAY ON TEST | 6| 2| 2| 0| 6| 6| 2| 5| 9| 8| 2| 2| 2| 1| 9| 2| 2| 1| 0| 9| 6| 2| 6| 4| 7|
| 4| 9| 9| 4| 4| 5| 9| 7| 1| 5| 9| 9| 9| 9| 5| 9| 9| 8| 1| 5| 5| 9| 5| 3| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.6% HM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Acute | 2 2 |
Inflammation, Chronic | 2 2 2 2 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 3 3 4 3 4 4 3 3 3 4 |
Dilatation | 4 4 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + +|
Hypospermia | X |
Interstitial Cell, Hyperplasia | 1 2 |
Seminiferous Tubule, Atrophy | 4 3 3 2 3 3 |
Seminiferous Tubule, Hypospermia | 3 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + |
__________________________________________________________________________|
Bone Marrow | + + + + A + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 3 2 2 3 3|
Myelofibrosis | 3 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + M + + + + + + + + + + + + +|
Inguinal, Infiltration Cellular, | |
Plasma Cell | |
Lumbar, Infiltration Cellular, | |
Plasma Cell | |
Mediastinal, Infiltration Cellular, | |
Plasma Cell | |
Mediastinal, Lymphatic, Angiectasis | |
Renal, Infiltration Cellular, Plasma | |
Cell | 4 |
Renal, Lymphatic, Angiectasis | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M + + + + + + + + + M M + +|
Granuloma | |
Hyperplasia, Lymphoid | |
Infiltration Cellular, Plasma Cell | 3 4 3 4 3 2 4 3 3 4 4 3|
Lymphatic, Angiectasis | 4 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + M + + + + + + + + + + + M +|
Congestion | 2 |
Granuloma | 2 2 2 2 2 2 2 2 2 2 |
Infiltration Cellular, Plasma Cell | |
Lymphatic, Angiectasis | 2 4|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Fibrosis, Focal | 2 |
Hematopoietic Cell Proliferation | 2 2 1 2 1 2 2 2 2 3|
Necrosis, Focal | |
Pigmentation, Hemosiderin | 2 |
__________________________________________________________________________|
Thymus | + + M + + + M + + + + + + + M + + M + +|
_____________________________________________________________________________________________________________________|
Page 95
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 4| 4| 7| 6| 5| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 4| 7| 4| 6| 5|
DAY ON TEST | 6| 2| 2| 0| 6| 6| 2| 5| 9| 8| 2| 2| 2| 1| 9| 2| 2| 1| 0| 9| 6| 2| 6| 4| 7|
| 4| 9| 9| 4| 4| 5| 9| 7| 1| 5| 9| 9| 9| 9| 5| 9| 9| 8| 1| 5| 5| 9| 5| 3| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.6% HM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Congestion | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + M + + + M M M M M + + + + + M + +|
Ectasia | 2 3 3 |
Hypertrophy | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | 2 2 2|
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Congestion | 1 2 |
Alveolar Epithelium, Metaplasia | 3 |
Alveolus, Inflammation, Acute, Focal | |
Interstitium, Inflammation, Chronic | 3 |
Peribronchial, Inflammation, Chronic | 1 2 1 2 1 2 2 2 2|
Pleura, Inflammation, Chronic, Focal | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
Fungus | X |
Hemorrhage | 4 |
Inflammation, Acute | 4 4 |
Inflammation, Chronic | 2 2 2 |
Metaplasia, Squamous | 2 2 2 3 2 2 2 2 2|
Parasite Metazoan | 4 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + +|
__________________________________________________________________________|
Eye | + +|
Anterior Chamber, Inflammation, Acute| 4 |
Lens, Degeneration | 2|
Retina, Degeneration | 3|
Retrobulbar, Hemorrhage | 3 |
__________________________________________________________________________|
Harderian Gland | + |
Pigmentation | 3 |
_____________________________________________________________________________________________________________________|
Page 96
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 4| 4| 7| 6| 5| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 4| 7| 4| 6| 5|
DAY ON TEST | 6| 2| 2| 0| 6| 6| 2| 5| 9| 8| 2| 2| 2| 1| 9| 2| 2| 1| 0| 9| 6| 2| 6| 4| 7|
| 4| 9| 9| 4| 4| 5| 9| 7| 1| 5| 9| 9| 9| 9| 5| 9| 9| 8| 1| 5| 5| 9| 5| 3| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.6% HM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Fibrosis, Focal | 2 |
Mineralization, Focal | |
Nephropathy | 2 2 4 4 3 2 3 3 3 3 3 4 4 3 4 3 2 3 4 1|
Cortex, Necrosis, Focal | 3 |
Interstitial Tissue, Hyperplasia | |
Renal Tubule, Cyst | X |
Renal Tubule, Hyperplasia | 2 2 |
Renal Tubule, Pigmentation | |
Transitional Epithelium, Hyperplasia,| |
Focal | 3 |
Transitional Epithelium, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + A + + + + + A + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 97
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 6| 7| 6| 7| 6| 5| 5| 3| 7| 7| 5| 5| 4| 7| 4| 7| 7| 7|
DAY ON TEST | 3| 3| 0| 6| 7| 3| 3| 5| 2| 4| 3| 1| 7| 6| 0| 3| 3| 8| 3| 4| 3| 6| 3| 3| 3|
| 1| 1| 4| 9| 9| 1| 0| 4| 3| 4| 1| 3| 7| 4| 5| 0| 0| 6| 3| 2| 0| 4| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.6% HM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + A + + + +|
Parasite Metazoan | 3 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 2 4 |
__________________________________________________________________________|
Intestine Large, Rectum | + + M + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 3 2 4 3|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + A + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Clear Cell Focus | X X |
Congestion | |
Eosinophilic Focus | |
Fatty Change | 3 |
Hepatodiaphragmatic Nodule | X X |
Hyperplasia, Focal | 2 2 |
Necrosis, Focal | 1 |
Bile Duct, Hyperplasia | 2 2 3 2 2 2 2 2 1 1 2 2 2 2 2 2 3 2 2 3 1|
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | |
Edema | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | X |
Acinus, Atrophy, Focal | 2 3 1 1 2 2 1 2 4 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
Karyomegaly | 2 2 2 2 2 2 2 2 1 2 1 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Bulla | |
Hyperkeratosis | |
Hyperplasia, Basal Cell | 1 |
Inflammation, Chronic | 2 |
Ulcer | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Mineralization | 2 |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
Page 98
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 6| 7| 6| 7| 6| 5| 5| 3| 7| 7| 5| 5| 4| 7| 4| 7| 7| 7|
DAY ON TEST | 3| 3| 0| 6| 7| 3| 3| 5| 2| 4| 3| 1| 7| 6| 0| 3| 3| 8| 3| 4| 3| 6| 3| 3| 3|
| 1| 1| 4| 9| 9| 1| 0| 4| 3| 4| 1| 3| 7| 4| 5| 0| 0| 6| 3| 2| 0| 4| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.6% HM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 3 3 2 2 2 3 2 4 2 3 1 3 2 2 3|
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Cytoplasmic Alteration, Focal | 3 |
Hemorrhage, Focal | |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + M + + + + + + + + M + + + + + + + +|
Hyperplasia, Focal | 2 3 |
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + M + + + + + M + + +|
Hyperplasia | 2 1 4 2 2 |
__________________________________________________________________________|
Pituitary Gland | + + M + + + + M + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia, Focal | 2 2 3 2 1 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 3 2 3 4 2 3|
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Focal | |
__________________________________________________________________________|
Penis | + |
Concretion | 3 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + M + + + + M + + + +|
Abscess | 3 2 |
Ectasia | 3|
Inflammation, Acute | 2 |
Inflammation, Chronic | 1 1 1 2 2 2 2|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Atrophy | 3 4 3 3 4 2 4 3|
Hyperplasia, Focal | 2 3 |
_____________________________________________________________________________________________________________________|
Page 99
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 6| 7| 6| 7| 6| 5| 5| 3| 7| 7| 5| 5| 4| 7| 4| 7| 7| 7|
DAY ON TEST | 3| 3| 0| 6| 7| 3| 3| 5| 2| 4| 3| 1| 7| 6| 0| 3| 3| 8| 3| 4| 3| 6| 3| 3| 3|
| 1| 1| 4| 9| 9| 1| 0| 4| 3| 4| 1| 3| 7| 4| 5| 0| 0| 6| 3| 2| 0| 4| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.6% HM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Acute | 3 3 1 |
Inflammation, Chronic | 4 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 3 4 3 4 4 2 4 4 4 4 4|
Dilatation | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +|
Hypospermia | |
Interstitial Cell, Hyperplasia | 2 |
Seminiferous Tubule, Atrophy | 4 3 4 3 3 3 3 3 3 3 2 3 3|
Seminiferous Tubule, Hypospermia | 3 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + I + + +|
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 3 2 3 3 3 2 3 2 2|
Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Infiltration Cellular, | |
Plasma Cell | 4 |
Lumbar, Infiltration Cellular, | |
Plasma Cell | 4 |
Mediastinal, Infiltration Cellular, | |
Plasma Cell | 2 |
Mediastinal, Lymphatic, Angiectasis | 3 |
Renal, Infiltration Cellular, Plasma | |
Cell | 4 |
Renal, Lymphatic, Angiectasis | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + M + + + + M + + + + + + + +|
Granuloma | 2 |
Hyperplasia, Lymphoid | 4 |
Infiltration Cellular, Plasma Cell | 4 4 2 4 4 3 2 2 4 2 3 |
Lymphatic, Angiectasis | 3 4|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 2 |
Granuloma | 2 2 2 2 2 2 2 2 2 2|
Infiltration Cellular, Plasma Cell | |
Lymphatic, Angiectasis | 4 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Fibrosis, Focal | 3 4 2 3 2 |
Hematopoietic Cell Proliferation | 2 2 2 2 3 2|
Necrosis, Focal | |
Pigmentation, Hemosiderin | 2 3 2 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + M + + + + + + M + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 100
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 6| 7| 6| 7| 6| 5| 5| 3| 7| 7| 5| 5| 4| 7| 4| 7| 7| 7|
DAY ON TEST | 3| 3| 0| 6| 7| 3| 3| 5| 2| 4| 3| 1| 7| 6| 0| 3| 3| 8| 3| 4| 3| 6| 3| 3| 3|
| 1| 1| 4| 9| 9| 1| 0| 4| 3| 4| 1| 3| 7| 4| 5| 0| 0| 6| 3| 2| 0| 4| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.6% HM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Congestion | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + + + + M + + + + + + + + + + M + + + + +|
Ectasia | 4 2 |
Hypertrophy | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + M + + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | 1 |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Alveolar Epithelium, Metaplasia | 2 2 |
Alveolus, Inflammation, Acute, Focal | |
Interstitium, Inflammation, Chronic | |
Peribronchial, Inflammation, Chronic | 2 1 2 2 2 2 1 2|
Pleura, Inflammation, Chronic, Focal | 2 |
__________________________________________________________________________|
Nose | + + M + + + + + + + + + + + + + + + + + + + + +|
Fungus | X|
Hemorrhage | |
Inflammation, Acute | 4|
Inflammation, Chronic | 2 2 2 2 1 |
Metaplasia, Squamous | 2 2 2 2 2 2 3 2 2 2 3|
Parasite Metazoan | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + + + |
Anterior Chamber, Inflammation, Acute| |
Lens, Degeneration | |
Retina, Degeneration | |
Retrobulbar, Hemorrhage | |
__________________________________________________________________________|
Harderian Gland | + + + + |
Pigmentation | 2 2 3 2 |
_____________________________________________________________________________________________________________________|
Page 101
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 6| 7| 6| 7| 6| 5| 5| 3| 7| 7| 5| 5| 4| 7| 4| 7| 7| 7|
DAY ON TEST | 3| 3| 0| 6| 7| 3| 3| 5| 2| 4| 3| 1| 7| 6| 0| 3| 3| 8| 3| 4| 3| 6| 3| 3| 3|
| 1| 1| 4| 9| 9| 1| 0| 4| 3| 4| 1| 3| 7| 4| 5| 0| 0| 6| 3| 2| 0| 4| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.6% HM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Fibrosis, Focal | |
Mineralization, Focal | 3 |
Nephropathy | 3 3 3 3 2 3 3 2 4 4 4 3 2 2 3 4 1 1 1 2 4 2 3|
Cortex, Necrosis, Focal | |
Interstitial Tissue, Hyperplasia | |
Renal Tubule, Cyst | X X |
Renal Tubule, Hyperplasia | 3 1 |
Renal Tubule, Pigmentation | 2 |
Transitional Epithelium, Hyperplasia,| |
Focal | |
Transitional Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + A + + + + A + + + +|
_____________________________________________________________________________________________________________________|
Page 102
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
__________________________________________________________________________________________________________________________________
| 4| 4| 7| 4| 7| 7| 7| 6| 4| 6| | |
DAY ON TEST | 6| 6| 3| 6| 3| 3| 3| 1| 6| 0| | |
| 5| 4| 0| 4| 0| 0| 0| 9| 4| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.6% HM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + | 48 |
Parasite Metazoan | | 4 2.5|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + | 50 |
Parasite Metazoan | | 5 2.4|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + | 49 |
Parasite Metazoan | | 8 3.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + | 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + | 49 |
Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Liver | + + + + + + | 50 |
Basophilic Focus | | 2 1.0|
Clear Cell Focus | | 2 |
Congestion | | 1 1.0|
Eosinophilic Focus | | 1 3.0|
Fatty Change | 1 | 3 1.7|
Hepatodiaphragmatic Nodule | | 4 |
Hyperplasia, Focal | 2 2 | 4 2.0|
Necrosis, Focal | | 1 1.0|
Bile Duct, Hyperplasia | 2 1 2 1 2 | 43 2.0|
Centrilobular, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | | 2 |
Edema | | 1 3.0|
Fat, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + M + | 47 |
Ectopic Tissue | | 1 |
Acinus, Atrophy, Focal | 4 3 2 | 20 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + | 50 |
Karyomegaly | 2 2 2 2 2 2 | 48 1.9|
__________________________________________________________________________|____________|
Stomach | + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + | 50 |
Acanthosis | 2 | 2 2.5|
Bulla | 4 | 1 4.0|
Hyperkeratosis | | 1 1.0|
Hyperplasia, Basal Cell | | 1 1.0|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 103
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
__________________________________________________________________________________________________________________________________
| 4| 4| 7| 4| 7| 7| 7| 6| 4| 6| | |
DAY ON TEST | 6| 6| 3| 6| 3| 3| 3| 1| 6| 0| | |
| 5| 4| 0| 4| 0| 0| 0| 9| 4| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.6% HM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + | 50 |
Inflammation, Chronic | | 1 2.0|
Mineralization | | 2 2.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + | 50 |
Cardiomyopathy | 3 2 1 3 | 35 2.1|
Atrium, Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + | 50 |
Atrophy | | 1 3.0|
Cytoplasmic Alteration, Focal | | 3 2.3|
Hemorrhage, Focal | | 1 3.0|
Vacuolization Cytoplasmic | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + | 46 |
Hyperplasia, Focal | 2 | 5 2.2|
Hyperplasia | 2 | 2 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + M + | 48 |
Hyperplasia | 1 | 2 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + | 45 |
Hyperplasia | | 8 2.4|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + | 48 |
Pars Distalis, Cyst | X | 2 |
Pars Distalis, Hyperplasia, Focal | 2 3 | 10 2.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + | 50 |
C-Cell, Hyperplasia | 4 2 2 | 13 2.5|
Follicle, Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + | 50 |
Degeneration, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Penis | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 104
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
__________________________________________________________________________________________________________________________________
| 4| 4| 7| 4| 7| 7| 7| 6| 4| 6| | |
DAY ON TEST | 6| 6| 3| 6| 3| 3| 3| 1| 6| 0| | |
| 5| 4| 0| 4| 0| 0| 0| 9| 4| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.6% HM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Concretion | | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + | 47 |
Abscess | 2 | 3 2.3|
Ectasia | | 1 3.0|
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic | | 15 1.5|
__________________________________________________________________________|____________|
Prostate | + + + + + + | 49 |
Abscess | | 1 4.0|
Atrophy | 4 4 | 13 3.5|
Hyperplasia, Focal | | 3 2.3|
Inflammation, Acute | | 5 2.2|
Inflammation, Chronic | | 7 2.1|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + | 50 |
Atrophy | 4 4 3 3 4 | 29 3.6|
Dilatation | | 2 4.0|
__________________________________________________________________________|____________|
Testes | + + + + + + | 50 |
Hypospermia | | 1 |
Interstitial Cell, Hyperplasia | | 3 1.7|
Seminiferous Tubule, Atrophy | 3 3 3 3 2 3 | 25 3.0|
Seminiferous Tubule, Hypospermia | | 4 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + | 23 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + | 49 |
Hyperplasia | 3 3 | 20 2.6|
Myelofibrosis | | 3 2.7|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + | 49 |
Inguinal, Infiltration Cellular, | | |
Plasma Cell | | 1 4.0|
Lumbar, Infiltration Cellular, | | |
Plasma Cell | | 1 4.0|
Mediastinal, Infiltration Cellular, | | |
Plasma Cell | | 1 2.0|
Mediastinal, Lymphatic, Angiectasis | | 1 3.0|
Renal, Infiltration Cellular, Plasma | | |
Cell | | 2 4.0|
Renal, Lymphatic, Angiectasis | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + | 45 |
Granuloma | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 105
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
__________________________________________________________________________________________________________________________________
| 4| 4| 7| 4| 7| 7| 7| 6| 4| 6| | |
DAY ON TEST | 6| 6| 3| 6| 3| 3| 3| 1| 6| 0| | |
| 5| 4| 0| 4| 0| 0| 0| 9| 4| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.6% HM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia, Lymphoid | | 1 4.0|
Infiltration Cellular, Plasma Cell | 2 2 3 2 | 27 3.1|
Lymphatic, Angiectasis | 4 | 5 3.8|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + | 48 |
Congestion | | 3 2.3|
Granuloma | 2 2 | 22 2.0|
Infiltration Cellular, Plasma Cell | 3 | 1 3.0|
Lymphatic, Angiectasis | | 4 3.3|
__________________________________________________________________________|____________|
Spleen | + + + + + + | 50 |
Congestion | 2 | 1 2.0|
Fibrosis, Focal | | 6 2.7|
Hematopoietic Cell Proliferation | 2 2 4 2 | 20 2.1|
Necrosis, Focal | 4 | 1 4.0|
Pigmentation, Hemosiderin | | 5 2.2|
__________________________________________________________________________|____________|
Thymus | + M M + + + | 42 |
Congestion | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M + M M | 36 |
Ectasia | | 5 2.8|
Hypertrophy | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + M | 49 |
Hyperkeratosis | 4 | 2 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + | 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + | 49 |
Hydrocephalus | | 4 1.8|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + | 50 |
Congestion | | 3 1.7|
Alveolar Epithelium, Metaplasia | | 3 2.3|
Alveolus, Inflammation, Acute, Focal | 4 | 1 4.0|
Interstitium, Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 106
NTP Experiment-Test: 05035-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:14
__________________________________________________________________________________________________________________________________
| 4| 4| 7| 4| 7| 7| 7| 6| 4| 6| | |
DAY ON TEST | 6| 6| 3| 6| 3| 3| 3| 1| 6| 0| | |
| 5| 4| 0| 4| 0| 0| 0| 9| 4| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.6% HM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Peribronchial, Inflammation, Chronic | 2 | 18 1.7|
Pleura, Inflammation, Chronic, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + | 49 |
Fungus | 4 | 3 4.0|
Hemorrhage | | 1 4.0|
Inflammation, Acute | 4 | 4 4.0|
Inflammation, Chronic | 2 3 | 10 2.0|
Metaplasia, Squamous | 2 3 | 22 2.2|
Parasite Metazoan | 2 | 2 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 3 |
__________________________________________________________________________|____________|
Eye | + + | 8 |
Anterior Chamber, Inflammation, Acute| | 1 4.0|
Lens, Degeneration | 2 | 2 2.0|
Retina, Degeneration | 3 | 2 3.0|
Retrobulbar, Hemorrhage | | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 6 |
Pigmentation | 2 | 6 2.3|
__________________________________________________________________________|____________|
Zymbal's Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + | 50 |
Congestion | | 1 3.0|
Fibrosis, Focal | | 1 2.0|
Mineralization, Focal | | 1 3.0|
Nephropathy | 2 3 3 3 2 4 | 49 2.8|
Cortex, Necrosis, Focal | | 1 3.0|
Interstitial Tissue, Hyperplasia | 2 | 1 2.0|
Renal Tubule, Cyst | X | 4 |
Renal Tubule, Hyperplasia | 1 | 5 1.8|
Renal Tubule, Pigmentation | | 1 2.0|
Transitional Epithelium, Hyperplasia,| | |
Focal | | 1 3.0|
Transitional Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + | 46 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 107
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