TDMS Study 05035-03 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Mason DATE: 09/05/94
EXP: 05035 4-HYDROXYACETANILIDE TIME: 00:31:13
TEST: 03 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: 55801
CONT: N01CP9561902 CAS: 103-90-2
PATHOLOGIST: A. RUSSFIELD S. EUSTIS
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Mason DATE: 09/05/94
EXP: 05035 4-HYDROXYACETANILIDE TIME: 00:31:13
TEST: 03 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: 55801
CONT: N01CP9561902 CAS: 103-90-2
PATHOLOGIST: A. RUSSFIELD S. EUSTIS
4-HYDROXYACETANILIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL UM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 23 CENSORED DEATHS 10 TERMINAL 27 |
| |
| UNCENSORED DEATHS |
| 460 514 568 568 579 582 612 631 632 632 |
| 635 640 641 652 661 661 670 682 703 708 |
| 712 714 718 |
| CENSORED DEATHS |
| 464 464 464 464 464 464 464 465 465 465 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.06% |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 22 CENSORED DEATHS 10 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 506 549 579 585 600 603 613 619 624 635 |
| 652 669 670 671 687 687 692 715 718 723 |
| 723 725 |
| CENSORED DEATHS |
| 464 464 464 464 464 465 465 465 465 465 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.3% |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 27 CENSORED DEATHS 10 TERMINAL 23 |
| |
| UNCENSORED DEATHS |
| 441 471 478 484 521 560 582 620 624 627 |
| 627 635 638 642 648 655 661 670 692 698 |
| 703 703 710 714 715 719 725 |
| CENSORED DEATHS |
| 464 464 465 465 465 465 465 465 465 465 |
| |
==================================================================================
4-HYDROXYACETANILIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0.6% |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 26 CENSORED DEATHS 10 TERMINAL 24 |
| |
| UNCENSORED DEATHS |
| 305 442 533 564 577 577 579 585 586 591 |
| 606 613 619 643 644 654 657 669 695 695 |
| 701 704 704 718 719 723 |
| CENSORED DEATHS |
| 464 464 464 464 464 464 465 465 465 465 |
| |
==================================================================================
4-HYDROXYACETANILIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL UM | 100.0 100.0 100.0 100.0 100.0 98.3 96.3 88.3 68.2 54.2 |
| | |
| | |
|0.06% | 100.0 100.0 100.0 100.0 100.0 100.0 98.0 88.0 78.0 56.0 |
| | |
| | |
|0.3% | 100.0 100.0 100.0 100.0 100.0 92.3 90.3 86.3 66.2 46.2 |
| | |
| | |
|0.6% | 100.0 100.0 100.0 98.3 98.3 96.7 94.7 80.6 66.5 48.3 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL UM 0.06% 0.3% 0.6% |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 54.2% 56.0% 46.2% 48.3% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.348 P=0.846N P=0.548 P=0.631 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 633.7 647.5 628.3 619.3 |
|NATURAL DEATHS (C) | (13.7) (13.1) (16.2) (18.3) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 648.4 655.0 639.6 637.4 |
|(STANDARD ERROR) | (13.2) (13.0) (13.8) (14.3) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
4-HYDROXYACETANILIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL UF |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 20 CENSORED DEATHS 10 TERMINAL 30 |
| |
| UNCENSORED DEATHS |
| 380 396 501 517 574 575 578 596 607 625 |
| 644 652 664 668 668 679 683 697 704 724 |
| CENSORED DEATHS |
| 463 463 463 463 463 464 464 464 464 464 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.06% |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 16 CENSORED DEATHS 10 TERMINAL 34 |
| |
| UNCENSORED DEATHS |
| 499 501 562 576 581 618 626 627 644 655 |
| 670 689 689 694 710 716 |
| CENSORED DEATHS |
| 463 463 463 463 463 464 464 464 464 464 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.3% |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 16 CENSORED DEATHS 10 TERMINAL 34 |
| |
| UNCENSORED DEATHS |
| 372 456 485 506 519 534 570 590 591 611 |
| 613 644 676 689 715 718 |
| CENSORED DEATHS |
| 463 463 463 463 463 464 464 464 464 464 |
| |
==================================================================================
4-HYDROXYACETANILIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0.6% |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 22 CENSORED DEATHS 10 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 245 308 354 471 519 554 585 585 611 614 |
| 628 639 640 640 652 662 668 672 678 690 |
| 693 708 |
| CENSORED DEATHS |
| 463 463 463 463 463 464 464 464 464 464 |
| |
==================================================================================
4-HYDROXYACETANILIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL UF | 100.0 100.0 100.0 100.0 96.7 96.7 92.6 84.6 74.5 60.4 |
| | |
| | |
|0.06% | 100.0 100.0 100.0 100.0 100.0 100.0 96.0 90.0 80.0 68.0 |
| | |
| | |
|0.3% | 100.0 100.0 100.0 100.0 98.3 94.7 88.6 82.6 76.5 68.5 |
| | |
| | |
|0.6% | 100.0 100.0 98.3 95.0 95.0 93.0 91.0 84.9 68.7 56.6 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL UF 0.06% 0.3% 0.6% |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 60.4% 68.0% 68.5% 56.6% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.433 P=0.469N P=0.590N P=0.754 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 606.6 628.6 580.6 582.5 |
|NATURAL DEATHS (C) | (21.5) (17.2) (24.5) (27.4) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 644.0 658.0 645.2 631.1 |
|(STANDARD ERROR) | (14.5) (13.4) (14.8) (16.4) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
4-HYDROXYACETANILIDE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL UM = 1
0.06% = 2
0.3% = 3
0.6% = 4
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 4 3 1 2
| 4 34 1 33 21 4 2 1
| 33 4 2 4 22
| 3 3 4112 2
P 90 + 3 3 11 22
E | 3 41 213 1
R | 222
C | 4 4 22
E 80 + 4 4 2 2
N | 444311 2 2
T | 4 1 1
| 331 12 2
S 70 + 433
U | 3 11
R | 31 1241 2
V | 331122
I 60 + 33
V |
A | 3112 1
L | 33
50 + 44
| 33 4
| 3 3
|
40 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 38 obs hidden.
4-HYDROXYACETANILIDE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL UF = 1
0.06% = 2
0.3% = 3
0.6% = 4
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 4 3 1 2
| 4 4 3 1 1 3
|
| 4 4 1 3 3 1 2
95 + 4 4 3 131
| 2 2
| 4 31 3 1
| 3 3 4 11
90 + 2 2
| 3 4 3 4
P | 22
E | 31 31
R 85 + 4 114
C | 2 2
E | 3 13 1 2 2
N | 4 4
T 80 + 1 1 2 2
| 3 4 1 1
S | 2 2
U | 3 1 1 3
R 75 + 113 3
V | 22
I | 4 4 32 23
V | 4 4
A 70 + 11 22
L | 4411 3 3
| 2 2
| 1 1
65 + 44 11
|
| 4 4 1 1
|
60 + 1 1
| 4 4
|
| 4 4
55 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 8 obs hidden.
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