TDMS Study 05043-01 Pathology Tables
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
Facility: TSI Mason Research
Chemical CAS #: 137-09-7
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 4| 4| 7| 6| 7| 6| 7| 6| 7| 4| 7| 7| 4| 1| 7| 7| 7| 7| 6|
DAY ON TEST | 1| 3| 5| 3| 3| 0| 5| 2| 3| 2| 3| 8| 3| 6| 1| 5| 3| 3| 5| 9| 3| 3| 3| 3| 0|
| 7| 5| 2| 5| 6| 4| 2| 1| 5| 7| 6| 0| 5| 8| 1| 2| 6| 6| 0| 3| 5| 5| 6| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
72VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Basophilic Focus | X X X X X X X X X X X X X X |
Clear Cell Focus | X X |
Eosinophilic Focus | |
Fatty Change | 4 2 3 3 2 1 1 3 |
Granuloma | 3 |
Hepatodiaphragmatic Nodule | X X X |
Inflammation, Chronic | |
Inflammation, Granulomatous | 2 2 |
Mixed Cell Focus | X |
Bile Duct, Hyperplasia | 3 3 2 1 2 1 1 1 3 1 1 |
Centrilobular, Inflammation, Acute | 3 |
Centrilobular, Necrosis | 3 |
Midzonal, Necrosis | |
Sinusoid, Embolus Bacterial | |
__________________________________________________________________________|
Mesentery | + + + |
Inflammation, Chronic | |
Fat, Necrosis, Focal | 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 1 |
Acinus, Hyperplasia, Focal | 2 |
Serosa, Neovascularization, Diffuse | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + +|
Embolus Bacterial | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 2 2|
__________________________________________________________________________|
Stomach, Glandular | + + + M + + + + + + M + + + + + + + + + +|
Embolus Bacterial | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 2 1 1 |
Interstitium, Embolus Bacterial | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 4| 4| 7| 6| 7| 6| 7| 6| 7| 4| 7| 7| 4| 1| 7| 7| 7| 7| 6|
DAY ON TEST | 1| 3| 5| 3| 3| 0| 5| 2| 3| 2| 3| 8| 3| 6| 1| 5| 3| 3| 5| 9| 3| 3| 3| 3| 0|
| 7| 5| 2| 5| 6| 4| 2| 1| 5| 7| 6| 0| 5| 8| 1| 2| 6| 6| 0| 3| 5| 5| 6| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
72VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 3 3 2 2 2 |
Embolus Bacterial | |
Hyperplasia, Focal | |
Hyperplasia | 2 |
Necrosis | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + M + + + + + + M + + + + + + + + + + +|
Hyperplasia, Focal | |
Hyperplasia | 2 2 2 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + M + M M + + + + M M M + M + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Pars Distalis, Angiectasis | 3 |
Pars Distalis, Cyst | X X |
Pars Distalis, Embolus Bacterial | |
Pars Distalis, Hemorrhage | 2 3 |
Pars Distalis, Hyperplasia, Focal | 1|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +|
Embolus Bacterial | |
C-Cell, Hyperplasia | 3 1 1 2 2 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Necrosis | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + +|
Inflammation, Suppurative | |
Duct, Cyst | |
__________________________________________________________________________|
Ovary | + + + + + + + + + M + + + + + + + + + + +|
Cyst | X |
Follicle, Cyst | |
__________________________________________________________________________|
Oviduct | + |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + +|
Cervix, Hyperplasia, Cystic | |
Endometrium, Hyperplasia, Cystic | |
__________________________________________________________________________|
Vagina | + |
Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 4| 4| 7| 6| 7| 6| 7| 6| 7| 4| 7| 7| 4| 1| 7| 7| 7| 7| 6|
DAY ON TEST | 1| 3| 5| 3| 3| 0| 5| 2| 3| 2| 3| 8| 3| 6| 1| 5| 3| 3| 5| 9| 3| 3| 3| 3| 0|
| 7| 5| 2| 5| 6| 4| 2| 1| 5| 7| 6| 0| 5| 8| 1| 2| 6| 6| 0| 3| 5| 5| 6| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
72VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone Marrow | + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Congestion | |
Mediastinal, Pigmentation, | |
Hemosiderin | |
Pancreatic, Pigmentation | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + M + + + + + + + + + +|
Congestion | 3 |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Pigmentation, Hemosiderin | 2 2 |
Pigmentation | 2 2 2 1 2 3 2 1 2 2 2 1 2|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + +|
Embolus Bacterial | |
Fibrosis | |
Hematopoietic Cell Proliferation | 3 2 |
Necrosis | |
Pigmentation, Hemosiderin | |
Thrombosis | X |
__________________________________________________________________________|
Thymus | + + + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 3 4 |
Hyperplasia | 4 2 |
__________________________________________________________________________|
Skin | + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + +|
Embolus Bacterial | |
Cerebrum, Perivascular, Inflammation | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + +|
Adenomatosis | 2 2|
Congestion | 3 2 3 |
Inflammation, Acute | |
Inflammation, Chronic, Focal | 2 |
Inflammation, Granulomatous | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 4| 4| 7| 6| 7| 6| 7| 6| 7| 4| 7| 7| 4| 1| 7| 7| 7| 7| 6|
DAY ON TEST | 1| 3| 5| 3| 3| 0| 5| 2| 3| 2| 3| 8| 3| 6| 1| 5| 3| 3| 5| 9| 3| 3| 3| 3| 0|
| 7| 5| 2| 5| 6| 4| 2| 1| 5| 7| 6| 0| 5| 8| 1| 2| 6| 6| 0| 3| 5| 5| 6| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
72VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 |
Capillary, Embolus Bacterial | |
__________________________________________________________________________|
Nose | + + + +|
Nasolacrimal Duct, Inflammation, | |
Chronic | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Lacrimal Gland | + |
__________________________________________________________________________|
Zymbal's Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Nephropathy | 2 2 1 2 4 3 2 3 2 1 1 1 1 1 4|
Capillary, Embolus Bacterial | |
Cortex, Cyst | X X |
Renal Tubule, Hyperplasia, Focal | 1|
Renal Tubule, Pigmentation, | |
Hemosiderin | 3 |
__________________________________________________________________________|
Urethra | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 5| 7| 7| 4| 7| 7| 4| 6| 7| 7| 6| 7| 7| 7| 7| 2| 7| 4| 7| 7| 6|
DAY ON TEST | 3| 0| 5| 3| 3| 3| 3| 5| 3| 3| 5| 8| 3| 3| 6| 3| 3| 3| 3| 4| 0| 8| 3| 0| 8|
| 5| 9| 0| 5| 6| 6| 6| 2| 6| 5| 2| 0| 6| 6| 7| 6| 6| 6| 6| 5| 9| 1| 6| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
72VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + A + |
__________________________________________________________________________|
Intestine Large, Cecum | + A + |
__________________________________________________________________________|
Intestine Large, Colon | + A + |
__________________________________________________________________________|
Intestine Large, Rectum | + A + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + A + |
__________________________________________________________________________|
Intestine Small, Jejunum | + A + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X |
Clear Cell Focus | X |
Eosinophilic Focus | 2 |
Fatty Change | 1 2 3 2 2 4|
Granuloma | |
Hepatodiaphragmatic Nodule | X X |
Inflammation, Chronic | 2 2 |
Inflammation, Granulomatous | 2 |
Mixed Cell Focus | |
Bile Duct, Hyperplasia | 1 1 1 2 3 4 1 2 2 2 1 2 |
Centrilobular, Inflammation, Acute | |
Centrilobular, Necrosis | |
Midzonal, Necrosis | 4 |
Sinusoid, Embolus Bacterial | 3 |
__________________________________________________________________________|
Mesentery | + |
Inflammation, Chronic | |
Fat, Necrosis, Focal | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + A + + + + +|
Acinus, Atrophy | 4 4 2 |
Acinus, Hyperplasia, Focal | |
Serosa, Neovascularization, Diffuse | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + |
Embolus Bacterial | 3 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + +|
Embolus Bacterial | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 1 1 3 1 2 1 |
Interstitium, Embolus Bacterial | 3 |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 5| 7| 7| 4| 7| 7| 4| 6| 7| 7| 6| 7| 7| 7| 7| 2| 7| 4| 7| 7| 6|
DAY ON TEST | 3| 0| 5| 3| 3| 3| 3| 5| 3| 3| 5| 8| 3| 3| 6| 3| 3| 3| 3| 4| 0| 8| 3| 0| 8|
| 5| 9| 0| 5| 6| 6| 6| 2| 6| 5| 2| 0| 6| 6| 7| 6| 6| 6| 6| 5| 9| 1| 6| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
72VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 3 2 3 3 2 4|
Embolus Bacterial | 3 |
Hyperplasia, Focal | 3 1 |
Hyperplasia | 2 |
Necrosis | 3|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 2 3 |
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + M + + + + + + + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | X |
Pars Distalis, Embolus Bacterial | 2 |
Pars Distalis, Hemorrhage | |
Pars Distalis, Hyperplasia, Focal | 1 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + +|
Embolus Bacterial | 3 |
C-Cell, Hyperplasia | 3 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Necrosis | 4 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + |
Inflammation, Suppurative | |
Duct, Cyst | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Follicle, Cyst | X |
__________________________________________________________________________|
Oviduct | + + |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + +|
Cervix, Hyperplasia, Cystic | 3 |
Endometrium, Hyperplasia, Cystic | 4 |
__________________________________________________________________________|
Vagina | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 5| 7| 7| 4| 7| 7| 4| 6| 7| 7| 6| 7| 7| 7| 7| 2| 7| 4| 7| 7| 6|
DAY ON TEST | 3| 0| 5| 3| 3| 3| 3| 5| 3| 3| 5| 8| 3| 3| 6| 3| 3| 3| 3| 4| 0| 8| 3| 0| 8|
| 5| 9| 0| 5| 6| 6| 6| 2| 6| 5| 2| 0| 6| 6| 7| 6| 6| 6| 6| 5| 9| 1| 6| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
72VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone Marrow | + A + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + A + + + + +|
Mediastinal, Congestion | 3 |
Mediastinal, Pigmentation, | |
Hemosiderin | 4 3 |
Pancreatic, Pigmentation | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + A + + M + +|
Congestion | |
Hyperplasia, Plasma Cell | 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + A + + + + +|
Congestion | 3 |
Pigmentation, Hemosiderin | |
Pigmentation | 1 2 2 1 1 1 2 2 2 2 2 1 2 2|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + +|
Embolus Bacterial | 3 |
Fibrosis | 3 |
Hematopoietic Cell Proliferation | |
Necrosis | 4 |
Pigmentation, Hemosiderin | 4 4 |
Thrombosis | |
__________________________________________________________________________|
Thymus | + A + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + |
Hyperplasia, Cystic | 4 |
Hyperplasia | 3 |
__________________________________________________________________________|
Skin | + + + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + +|
Embolus Bacterial | 3 |
Cerebrum, Perivascular, Inflammation | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + +|
Adenomatosis | |
Congestion | 3 4 |
Inflammation, Acute | 1 |
Inflammation, Chronic, Focal | |
Inflammation, Granulomatous | |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 5| 7| 7| 4| 7| 7| 4| 6| 7| 7| 6| 7| 7| 7| 7| 2| 7| 4| 7| 7| 6|
DAY ON TEST | 3| 0| 5| 3| 3| 3| 3| 5| 3| 3| 5| 8| 3| 3| 6| 3| 3| 3| 3| 4| 0| 8| 3| 0| 8|
| 5| 9| 0| 5| 6| 6| 6| 2| 6| 5| 2| 0| 6| 6| 7| 6| 6| 6| 6| 5| 9| 1| 6| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
72VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
Capillary, Embolus Bacterial | 3 |
__________________________________________________________________________|
Nose | + + + |
Nasolacrimal Duct, Inflammation, | |
Chronic | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | |
__________________________________________________________________________|
Lacrimal Gland | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Nephropathy | 2 1 2 1 2 2 4 2 2 2 2 |
Capillary, Embolus Bacterial | 4 |
Cortex, Cyst | |
Renal Tubule, Hyperplasia, Focal | |
Renal Tubule, Pigmentation, | |
Hemosiderin | |
__________________________________________________________________________|
Urethra | + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + A + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
__________________________________________________________________________________________________________________________________
| 1| 7| 7| 4| 7| 7| 4| 2| 4| 7| | |
DAY ON TEST | 9| 3| 3| 5| 3| 3| 5| 4| 5| 3| | |
| 9| 6| 6| 0| 6| 6| 2| 6| 2| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
VEHICLE | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
72VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large | + + + | 9 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + | 8 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 9 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + | 8 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + | 8 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + | 8 |
__________________________________________________________________________|____________|
Liver | + + + + + + + | 50 |
Angiectasis, Focal | 2 | 1 2.0|
Basophilic Focus | X X X | 36 |
Clear Cell Focus | | 3 |
Eosinophilic Focus | | 1 2.0|
Fatty Change | | 14 2.4|
Granuloma | | 1 3.0|
Hepatodiaphragmatic Nodule | | 5 |
Inflammation, Chronic | 2 | 3 2.0|
Inflammation, Granulomatous | 1 | 4 1.8|
Mixed Cell Focus | | 1 |
Bile Duct, Hyperplasia | 1 2 | 25 1.8|
Centrilobular, Inflammation, Acute | | 1 3.0|
Centrilobular, Necrosis | | 1 3.0|
Midzonal, Necrosis | | 1 4.0|
Sinusoid, Embolus Bacterial | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + | 6 |
Inflammation, Chronic | 3 | 1 3.0|
Fat, Necrosis, Focal | | 3 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + | 49 |
Acinus, Atrophy | | 5 2.6|
Acinus, Hyperplasia, Focal | | 1 2.0|
Serosa, Neovascularization, Diffuse | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + | 21 |
Embolus Bacterial | | 1 3.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + | 50 |
Ulcer | | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + | 48 |
Embolus Bacterial | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
__________________________________________________________________________________________________________________________________
| 1| 7| 7| 4| 7| 7| 4| 2| 4| 7| | |
DAY ON TEST | 9| 3| 3| 5| 3| 3| 5| 4| 5| 3| | |
| 9| 6| 6| 0| 6| 6| 2| 6| 2| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
VEHICLE | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
72VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + | 50 |
Cardiomyopathy | 1 1 | 16 1.3|
Interstitium, Embolus Bacterial | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + | 50 |
Degeneration | 2 | 12 2.6|
Embolus Bacterial | | 1 3.0|
Hyperplasia, Focal | 2 | 3 2.0|
Hyperplasia | | 2 2.0|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + | 47 |
Hyperplasia, Focal | | 3 2.3|
Hyperplasia | | 4 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + | 49 |
Hyperplasia | 2 | 2 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | M + + M + + + | 38 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + | 50 |
Cyst | X | 3 |
Pars Distalis, Angiectasis | 2 | 2 2.5|
Pars Distalis, Cyst | | 3 |
Pars Distalis, Embolus Bacterial | | 1 2.0|
Pars Distalis, Hemorrhage | | 2 2.5|
Pars Distalis, Hyperplasia, Focal | | 3 1.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + | 50 |
Embolus Bacterial | | 1 3.0|
C-Cell, Hyperplasia | 3 | 10 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Necrosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + | 12 |
Inflammation, Suppurative | 3 | 1 3.0|
Duct, Cyst | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
__________________________________________________________________________________________________________________________________
| 1| 7| 7| 4| 7| 7| 4| 2| 4| 7| | |
DAY ON TEST | 9| 3| 3| 5| 3| 3| 5| 4| 5| 3| | |
| 9| 6| 6| 0| 6| 6| 2| 6| 2| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
VEHICLE | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
72VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + | 49 |
Cyst | | 1 |
Follicle, Cyst | | 1 |
__________________________________________________________________________|____________|
Oviduct | | 3 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + | 50 |
Cervix, Hyperplasia, Cystic | | 1 3.0|
Endometrium, Hyperplasia, Cystic | 3 | 2 3.5|
__________________________________________________________________________|____________|
Vagina | | 1 |
Inflammation, Suppurative | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + | 8 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + | 49 |
Mediastinal, Congestion | | 1 3.0|
Mediastinal, Pigmentation, | | |
Hemosiderin | 3 | 3 3.3|
Pancreatic, Pigmentation | | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + M M + + | 44 |
Congestion | | 1 3.0|
Hyperplasia, Plasma Cell | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + | 49 |
Congestion | | 1 3.0|
Pigmentation, Hemosiderin | | 2 2.0|
Pigmentation | 2 2 3 2 2 | 32 1.8|
__________________________________________________________________________|____________|
Spleen | + + + + + + + | 50 |
Embolus Bacterial | | 1 3.0|
Fibrosis | | 1 3.0|
Hematopoietic Cell Proliferation | | 2 2.5|
Necrosis | | 1 4.0|
Pigmentation, Hemosiderin | | 2 4.0|
Thrombosis | | 1 |
__________________________________________________________________________|____________|
Thymus | + + | 7 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + | 27 |
Hyperplasia, Cystic | 4 | 4 3.8|
Hyperplasia | | 3 3.0|
__________________________________________________________________________|____________|
Skin | + + | 12 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
__________________________________________________________________________________________________________________________________
| 1| 7| 7| 4| 7| 7| 4| 2| 4| 7| | |
DAY ON TEST | 9| 3| 3| 5| 3| 3| 5| 4| 5| 3| | |
| 9| 6| 6| 0| 6| 6| 2| 6| 2| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
VEHICLE | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
72VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone | + + | 9 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + | 50 |
Embolus Bacterial | | 1 3.0|
Cerebrum, Perivascular, Inflammation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + | 50 |
Adenomatosis | | 2 2.0|
Congestion | | 5 3.0|
Inflammation, Acute | | 1 1.0|
Inflammation, Chronic, Focal | | 1 2.0|
Inflammation, Granulomatous | 1 | 1 1.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 1 2.0|
Capillary, Embolus Bacterial | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + | 9 |
Nasolacrimal Duct, Inflammation, | | |
Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 2 |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
__________________________________________________________________________|____________|
Lacrimal Gland | | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + | 50 |
Congestion | | 1 3.0|
Nephropathy | 2 1 3 2 2 | 31 2.0|
Capillary, Embolus Bacterial | | 1 4.0|
Cortex, Cyst | | 2 |
Renal Tubule, Hyperplasia, Focal | | 1 1.0|
Renal Tubule, Pigmentation, | | |
Hemosiderin | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
__________________________________________________________________________________________________________________________________
| 1| 7| 7| 4| 7| 7| 4| 2| 4| 7| | |
DAY ON TEST | 9| 3| 3| 5| 3| 3| 5| 4| 5| 3| | |
| 9| 6| 6| 0| 6| 6| 2| 6| 2| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
VEHICLE | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
72VF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urethra | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + | 49 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 6| 4| 4| 4| 7| 6| 5| 4| 7| 7| 7| 4| 4|
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 3| 5| 3| 3| 5| 5| 2| 5| 0| 9| 4| 8| 3| 3| 1| 5| 4|
| 1| 1| 1| 1| 0| 1| 1| 1| 1| 2| 1| 1| 3| 0| 2| 2| 4| 4| 0| 0| 2| 2| 4| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
.0125 G/ | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
KG 72LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + M|
__________________________________________________________________________|
Intestine Large | + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + +|
Mucosa, Pigmentation | 4 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + +|
Lamina Propria, Pigmentation | 4 4 4 4 4 4 3 4 4 4 4 3 3 3 3 4 4 4 4 4 4|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X|
Congestion | 4 2 |
Fatty Change | 1 1 3 1 4 |
Hematopoietic Cell Proliferation | 1 |
Hemorrhage, Multifocal | |
Hepatodiaphragmatic Nodule | X |
Inflammation, Granulomatous | 3 |
Mixed Cell Focus | |
Necrosis, Multifocal | |
Bile Duct, Hyperplasia | 1 1 2 1 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis, Focal | 4 |
__________________________________________________________________________|
Pancreas | + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + +|
Pigmentation | |
Ulcer | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + +|
Cardiomyopathy | 2 |
Ventricle, Fibrosis | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + +|
Capsule, Degeneration | 3 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + +|
Congestion | |
Degeneration | 3 |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 6| 4| 4| 4| 7| 6| 5| 4| 7| 7| 7| 4| 4|
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 3| 5| 3| 3| 5| 5| 2| 5| 0| 9| 4| 8| 3| 3| 1| 5| 4|
| 1| 1| 1| 1| 0| 1| 1| 1| 1| 2| 1| 1| 3| 0| 2| 2| 4| 4| 0| 0| 2| 2| 4| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
.0125 G/ | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
KG 72LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | 2|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + +|
Congestion | |
Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + M|
Inflammation, Chronic | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Ovary | + + + + + +|
Follicle, Cyst | X |
__________________________________________________________________________|
Oviduct | + + + +|
__________________________________________________________________________|
Uterus | + + + + + + + +|
Hydrometra | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + +|
Lumbar, Cyst | |
Pancreatic, Pigmentation | 4 4 4 4 3 3 4 4 4 4 4 4 4 4 4 4 4 4|
__________________________________________________________________________|
Lymph Node, Mandibular | M + M + M|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Pigmentation | 2 3 1 2 2 2 2 2 2 2 4 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 4 |
__________________________________________________________________________|
Thymus | + + + M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + + + + + + + + + + + +|
Hyperplasia, Cystic | 3 |
Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 6| 4| 4| 4| 7| 6| 5| 4| 7| 7| 7| 4| 4|
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 3| 5| 3| 3| 5| 5| 2| 5| 0| 9| 4| 8| 3| 3| 1| 5| 4|
| 1| 1| 1| 1| 0| 1| 1| 1| 1| 2| 1| 1| 3| 0| 2| 2| 4| 4| 0| 0| 2| 2| 4| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
.0125 G/ | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
KG 72LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + +|
__________________________________________________________________________|
Spinal Cord | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + +|
Congestion | 3 2 3 3 |
Hemorrhage, Focal | |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
__________________________________________________________________________|
Nose | + + + + +|
__________________________________________________________________________|
Trachea | + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
__________________________________________________________________________|
Harderian Gland | + |
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 1 1 2 1 1 2 1 1 1 1 2 1 2 4 |
Papilla, Necrosis, Diffuse | |
Renal Tubule, Hyperplasia, Focal | 2 |
Renal Tubule, Pigmentation, | |
Hemosiderin | 3 3 3 2 3 3 3 3 3 2 2 2 2 3 2 3 3 3 4 3|
__________________________________________________________________________|
Urinary Bladder | + + + + M + + + + + + + + + + + + + + + +|
Submucosa, Inflammation, | |
Granulomatous | 4 |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 4| 7| 7| 5| 4| 4| 7| 7| 7| 7| 4| 7| 7| 6| 4| 3| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 5| 5| 3| 3| 6| 5| 5| 3| 3| 3| 3| 5| 3| 1| 1| 5| 4| 3| 3| 3| 3| 9|
| 2| 2| 2| 2| 0| 2| 2| 8| 0| 0| 2| 2| 2| 2| 0| 2| 6| 7| 2| 2| 2| 2| 2| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
.0125 G/ | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
KG 72LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + |
__________________________________________________________________________|
Intestine Large | + + + A + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + A A |
Mucosa, Pigmentation | |
__________________________________________________________________________|
Intestine Large, Colon | + + A A + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + A |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + +|
Lamina Propria, Pigmentation | 4 3 4 4 4 3 4 4 4 4 4 4 4 2 4 4 4 4 4|
__________________________________________________________________________|
Intestine Small, Ileum | + A A |
__________________________________________________________________________|
Intestine Small, Jejunum | + A + |
__________________________________________________________________________|
Liver | + + + + + + + + |
Basophilic Focus | X X X X |
Congestion | |
Fatty Change | 1 3 4 2 |
Hematopoietic Cell Proliferation | |
Hemorrhage, Multifocal | 3 |
Hepatodiaphragmatic Nodule | |
Inflammation, Granulomatous | |
Mixed Cell Focus | |
Necrosis, Multifocal | 3 |
Bile Duct, Hyperplasia | 2 1 2 |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis, Focal | 4 4 4 |
__________________________________________________________________________|
Pancreas | + + + |
__________________________________________________________________________|
Salivary Glands | + + + |
__________________________________________________________________________|
Stomach | + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + |
Pigmentation | |
Ulcer | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + |
Cardiomyopathy | 3 |
Ventricle, Fibrosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + |
Capsule, Degeneration | |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + |
Congestion | 3 |
Degeneration | 2 |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 4| 7| 7| 5| 4| 4| 7| 7| 7| 7| 4| 7| 7| 6| 4| 3| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 5| 5| 3| 3| 6| 5| 5| 3| 3| 3| 3| 5| 3| 1| 1| 5| 4| 3| 3| 3| 3| 9|
| 2| 2| 2| 2| 0| 2| 2| 8| 0| 0| 2| 2| 2| 2| 0| 2| 6| 7| 2| 2| 2| 2| 2| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
.0125 G/ | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
KG 72LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + |
Congestion | 3 |
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + M |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia, Focal | 1 2 2 1 |
__________________________________________________________________________|
Thyroid Gland | + + + |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + M + |
Inflammation, Chronic | 2 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Ovary | + + + + + |
Follicle, Cyst | |
__________________________________________________________________________|
Oviduct | + |
__________________________________________________________________________|
Uterus | + + + |
Hydrometra | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + M + + + +|
Lumbar, Cyst | |
Pancreatic, Pigmentation | 4 4 4 4 4 4 4 4 3 4 4 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + M + + + +|
Congestion | |
Pigmentation | 2 2 3 3 2 1 3 2 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + |
Hematopoietic Cell Proliferation | 4 |
__________________________________________________________________________|
Thymus | + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + M + + + M + + |
Hyperplasia, Cystic | 4 |
Hyperplasia | 2 |
__________________________________________________________________________|
Skin | + + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 4| 7| 7| 5| 4| 4| 7| 7| 7| 7| 4| 7| 7| 6| 4| 3| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 5| 5| 3| 3| 6| 5| 5| 3| 3| 3| 3| 5| 3| 1| 1| 5| 4| 3| 3| 3| 3| 9|
| 2| 2| 2| 2| 0| 2| 2| 8| 0| 0| 2| 2| 2| 2| 0| 2| 6| 7| 2| 2| 2| 2| 2| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
.0125 G/ | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
KG 72LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + |
__________________________________________________________________________|
Spinal Cord | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + |
Congestion | 4 |
Hemorrhage, Focal | 3 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 |
__________________________________________________________________________|
Nose | + + + |
__________________________________________________________________________|
Trachea | + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + +|
__________________________________________________________________________|
Harderian Gland | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + +|
Nephropathy | 2 1 2 2 2 1 1 2 2 4 1 1 1 2 1 1 2|
Papilla, Necrosis, Diffuse | 4 |
Renal Tubule, Hyperplasia, Focal | |
Renal Tubule, Pigmentation, | |
Hemosiderin | 3 3 3 3 2 2 3 3 3 3 4 3 3 3 3 2 3 4|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + +|
Submucosa, Inflammation, | |
Granulomatous | |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 6| 6| 4| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 2| 2| 9| | |
| 5| 5| 5| 5| 4| 5| 5| 5| 0| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
.0125 G/ | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
KG 72LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + | 11 |
__________________________________________________________________________|____________|
Intestine Large | + + + + | 16 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + | 11 |
Mucosa, Pigmentation | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + | 14 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + | 11 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 50 |
Lamina Propria, Pigmentation | 4 4 4 4 3 4 4 3 4 3 | 50 3.8|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + | 11 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + | 30 |
Basophilic Focus | X X X X X X X | 19 |
Congestion | | 2 3.0|
Fatty Change | 3 3 2 | 12 2.3|
Hematopoietic Cell Proliferation | | 1 1.0|
Hemorrhage, Multifocal | | 1 3.0|
Hepatodiaphragmatic Nodule | X X | 3 |
Inflammation, Granulomatous | 2 | 2 2.5|
Mixed Cell Focus | X | 1 |
Necrosis, Multifocal | | 1 3.0|
Bile Duct, Hyperplasia | 1 1 2 | 10 1.4|
__________________________________________________________________________|____________|
Mesentery | + | 5 |
Fat, Necrosis, Focal | 4 | 5 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + | 13 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + | 12 |
__________________________________________________________________________|____________|
Stomach | + + + + | 14 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + | 14 |
Pigmentation | 1 | 1 1.0|
Ulcer | 4 | 3 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + | 13 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + | 13 |
Cardiomyopathy | | 2 2.5|
Ventricle, Fibrosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 6| 6| 4| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 2| 2| 9| | |
| 5| 5| 5| 5| 4| 5| 5| 5| 0| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
.0125 G/ | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
KG 72LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + | 15 |
Capsule, Degeneration | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + | 15 |
Congestion | | 1 3.0|
Degeneration | | 2 2.5|
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + | 15 |
Congestion | | 1 3.0|
Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + | 14 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + | 11 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 50 |
Pars Distalis, Angiectasis | 3 2 | 3 2.3|
Pars Distalis, Cyst | | 1 |
Pars Distalis, Hyperplasia, Focal | 3 2 | 7 1.9|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + | 12 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + M + + + + | 17 |
Inflammation, Chronic | | 1 2.0|
Inflammation, Suppurative | 4 | 1 4.0|
__________________________________________________________________________|____________|
Ovary | + + + + | 15 |
Follicle, Cyst | | 1 |
__________________________________________________________________________|____________|
Oviduct | + + | 7 |
__________________________________________________________________________|____________|
Uterus | + + + + | 15 |
Hydrometra | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + | 12 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 49 |
Lumbar, Cyst | X | 1 |
Pancreatic, Pigmentation | 4 4 4 4 4 | 35 3.9|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 49 |
Congestion | 3 | 1 3.0|
Pigmentation | 2 1 3 2 | 26 2.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 6| 6| 4| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 2| 2| 9| | |
| 5| 5| 5| 5| 4| 5| 5| 5| 0| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
.0125 G/ | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
KG 72LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + | 20 |
Hematopoietic Cell Proliferation | 4 | 4 4.0|
__________________________________________________________________________|____________|
Thymus | M + + + | 11 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + | 29 |
Hyperplasia, Cystic | 4 2 2 | 5 3.0|
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + | 13 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + | 12 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + M + | 11 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
Hemorrhage | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + | 17 |
Congestion | 3 3 | 7 3.0|
Hemorrhage, Focal | | 1 3.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + | 12 |
__________________________________________________________________________|____________|
Trachea | + + + + | 12 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 7 |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Inflammation, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 50 |
Nephropathy | 3 1 2 2 1 1 1 1 | 39 1.6|
Papilla, Necrosis, Diffuse | | 1 4.0|
Renal Tubule, Hyperplasia, Focal | | 1 2.0|
Renal Tubule, Pigmentation, | | |
Hemosiderin | 4 3 3 3 3 2 3 3 2 3 | 48 2.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 6| 6| 4| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 2| 2| 9| | |
| 5| 5| 5| 5| 4| 5| 5| 5| 0| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
.0125 G/ | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
KG 72LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 49 |
Submucosa, Inflammation, | | |
Granulomatous | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 3| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 4|
DAY ON TEST | 2| 2| 2| 4| 7| 3| 2| 2| 7| 5| 3| 3| 3| 3| 1| 3| 3| 3| 5| 3| 3| 3| 7| 5| 1|
| 9| 9| 9| 5| 1| 0| 9| 9| 9| 0| 0| 0| 0| 0| 1| 0| 0| 0| 3| 0| 0| 0| 0| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
.025G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
72HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + +|
Lamina Propria, Inflammation, Acute | |
Lamina Propria, Pigmentation | 4 4 4 3 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 3|
__________________________________________________________________________|
Intestine Small, Ileum | + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X |
Fatty Change | 2 4 |
Hematocyst | X |
Hepatodiaphragmatic Nodule | X X X |
Inflammation, Granulomatous | 1 2 2 2 2 |
Mixed Cell Focus | |
Necrosis, Focal | |
Bile Duct, Hyperplasia | 1 4 3 1 1 1 1 2 1 1 2 1 2 |
__________________________________________________________________________|
Mesentery | + + |
Inflammation, Chronic | 3 |
Fat, Necrosis, Focal | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Diffuse | |
Acinus, Atrophy | 3 2 |
Acinus, Hyperplasia, Focal | 2 |
Acinus, Hypertrophy, Focal | |
Artery, Inflammation, Chronic Active | 4 |
Duct, Cyst | X |
Duct, Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 4 2 |
Pigmentation | 2 4 2 |
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Erosion, Focal | 3 |
Hyperplasia, Focal | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 3| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 4|
DAY ON TEST | 2| 2| 2| 4| 7| 3| 2| 2| 7| 5| 3| 3| 3| 3| 1| 3| 3| 3| 5| 3| 3| 3| 7| 5| 1|
| 9| 9| 9| 5| 1| 0| 9| 9| 9| 0| 0| 0| 0| 0| 1| 0| 0| 0| 3| 0| 0| 0| 0| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
.025G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
72HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 3 2 1 1 2 1 2|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Degeneration, Focal | |
Degeneration | 3 2 |
Hyperplasia, Focal | 2 |
Hyperplasia | 2 |
Hypertrophy | 1 |
Necrosis | |
Vacuolization Cytoplasmic | 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + M + M + + M + M M + + + + M + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Pars Distalis, Angiectasis | 4 2 |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia, Focal | 3 2 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + +|
Inflammation, Suppurative | 1 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Oviduct | +|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + +|
Endometriosis | |
Hydrometra | 2 |
Endometrium, Hyperplasia, Cystic | 4 3 3 |
Lumen, Hemorrhage | |
Wall, Necrosis | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 3| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 4|
DAY ON TEST | 2| 2| 2| 4| 7| 3| 2| 2| 7| 5| 3| 3| 3| 3| 1| 3| 3| 3| 5| 3| 3| 3| 7| 5| 1|
| 9| 9| 9| 5| 1| 0| 9| 9| 9| 0| 0| 0| 0| 0| 1| 0| 0| 0| 3| 0| 0| 0| 0| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
.025G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
72HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone Marrow | + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Congestion | 2 |
Mediastinal, Pigmentation, | |
Hemosiderin | 3 |
Pancreatic, Pigmentation | 4 4 4 4 4 4 2 4 4 4 4 4 4 4 4 4 3|
Renal, Congestion | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + +|
Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + +|
Pigmentation | 4 4 4 3 2 4 4 4 3 4 4 4 4 4 4 4 3 4 4 3 4 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 |
__________________________________________________________________________|
Thymus | + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + +|
Hyperplasia, Cystic | 4 |
__________________________________________________________________________|
Skin | + + + + +|
Face, Abscess | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + +|
Adenomatosis | 2 |
Congestion | 3|
Interstitium, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + M +|
Nasolacrimal Duct, Inflammation, | |
Chronic | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
Lens, Mineralization | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 3| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 4|
DAY ON TEST | 2| 2| 2| 4| 7| 3| 2| 2| 7| 5| 3| 3| 3| 3| 1| 3| 3| 3| 5| 3| 3| 3| 7| 5| 1|
| 9| 9| 9| 5| 1| 0| 9| 9| 9| 0| 0| 0| 0| 0| 1| 0| 0| 0| 3| 0| 0| 0| 0| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
.025G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
72HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 2 2 1 3 4 1 2 3 2 2 1 2 1 2 1 3 2 |
Renal Tubule, Hyperplasia, Focal | 2 1 |
Renal Tubule, Pigmentation, | |
Hemosiderin | 4 3 4 4 4 4 4 4 3 4 4 4 4 4 4 4 4 3 4 3 4 4 4|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 7| 7| 6| 4| 7| 7| 7| 4| 2| 7| 6| 6| 4| 4| 7| 7| 6| 6| 6|
DAY ON TEST | 3| 3| 8| 5| 5| 3| 3| 0| 9| 5| 3| 3| 3| 5| 8| 3| 8| 6| 5| 5| 3| 3| 8| 7| 4|
| 0| 0| 7| 2| 0| 0| 0| 3| 5| 0| 1| 1| 1| 2| 2| 1| 1| 9| 0| 0| 1| 1| 8| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
.025G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
72HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + |
__________________________________________________________________________|
Intestine Large, Cecum | + |
__________________________________________________________________________|
Intestine Large, Colon | + |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | M |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + +|
Lamina Propria, Inflammation, Acute | 4 |
Lamina Propria, Pigmentation | 4 4 4 4 4 4 4 4 4 4 1 4 4 3 4 4 3 3 4|
__________________________________________________________________________|
Intestine Small, Ileum | + |
__________________________________________________________________________|
Intestine Small, Jejunum | M + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X|
Clear Cell Focus | X |
Fatty Change | 3 2 2 4 |
Hematocyst | |
Hepatodiaphragmatic Nodule | X X |
Inflammation, Granulomatous | 1 3 2 1 1 |
Mixed Cell Focus | X |
Necrosis, Focal | 2 |
Bile Duct, Hyperplasia | 1 2 2 1 2 2 1 1 1 1 2 1 2|
__________________________________________________________________________|
Mesentery | |
Inflammation, Chronic | |
Fat, Necrosis, Focal | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Diffuse | |
Acinus, Atrophy | 1 1 |
Acinus, Hyperplasia, Focal | 3 3 2 |
Acinus, Hypertrophy, Focal | 2 |
Artery, Inflammation, Chronic Active | |
Duct, Cyst | |
Duct, Hyperplasia | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 3 3 |
Pigmentation | 1 2 2 1 1 |
Ulcer | 1 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + M + + + + + +|
Edema | 3 |
Erosion, Focal | |
Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 7| 7| 6| 4| 7| 7| 7| 4| 2| 7| 6| 6| 4| 4| 7| 7| 6| 6| 6|
DAY ON TEST | 3| 3| 8| 5| 5| 3| 3| 0| 9| 5| 3| 3| 3| 5| 8| 3| 8| 6| 5| 5| 3| 3| 8| 7| 4|
| 0| 0| 7| 2| 0| 0| 0| 3| 5| 0| 1| 1| 1| 2| 2| 1| 1| 9| 0| 0| 1| 1| 8| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
.025G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
72HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 2 1 2 2 |
Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + +|
Congestion | |
Degeneration, Focal | 2 |
Degeneration | 4 4 |
Hyperplasia, Focal | |
Hyperplasia | |
Hypertrophy | |
Necrosis | |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + M + + + M +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + M + M M + + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + +|
Cyst | |
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia, Focal | 1 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + |
Inflammation, Suppurative | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Oviduct | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + +|
Endometriosis | |
Hydrometra | |
Endometrium, Hyperplasia, Cystic | 2 |
Lumen, Hemorrhage | 3 |
Wall, Necrosis | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 7| 7| 6| 4| 7| 7| 7| 4| 2| 7| 6| 6| 4| 4| 7| 7| 6| 6| 6|
DAY ON TEST | 3| 3| 8| 5| 5| 3| 3| 0| 9| 5| 3| 3| 3| 5| 8| 3| 8| 6| 5| 5| 3| 3| 8| 7| 4|
| 0| 0| 7| 2| 0| 0| 0| 3| 5| 0| 1| 1| 1| 2| 2| 1| 1| 9| 0| 0| 1| 1| 8| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
.025G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
72HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone Marrow | + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + +|
Mediastinal, Congestion | |
Mediastinal, Pigmentation, | |
Hemosiderin | |
Pancreatic, Pigmentation | 4 4 4 4 4 4 4 4 4 4 4 4|
Renal, Congestion | 4|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M + + + + + + + + + + |
Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + +|
Pigmentation | 4 4 3 2 3 4 4 4 4 3 4 4 3 4 4|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 |
__________________________________________________________________________|
Thymus | + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + + |
Hyperplasia, Cystic | |
__________________________________________________________________________|
Skin | + + |
Face, Abscess | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + +|
Adenomatosis | |
Congestion | 2 |
Interstitium, Inflammation, Chronic | 3 |
__________________________________________________________________________|
Nose | + |
Nasolacrimal Duct, Inflammation, | |
Chronic | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + |
__________________________________________________________________________|
Eye | + |
Lens, Mineralization | 3 |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 7| 7| 6| 4| 7| 7| 7| 4| 2| 7| 6| 6| 4| 4| 7| 7| 6| 6| 6|
DAY ON TEST | 3| 3| 8| 5| 5| 3| 3| 0| 9| 5| 3| 3| 3| 5| 8| 3| 8| 6| 5| 5| 3| 3| 8| 7| 4|
| 0| 0| 7| 2| 0| 0| 0| 3| 5| 0| 1| 1| 1| 2| 2| 1| 1| 9| 0| 0| 1| 1| 8| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
.025G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
72HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + +|
Nephropathy | 2 3 4 3 3 4 1 4 2 3 3 2 4 4 1 3 2 1|
Renal Tubule, Hyperplasia, Focal | 2 1 1 |
Renal Tubule, Pigmentation, | |
Hemosiderin | 4 3 4 4 4 4 4 4 4 4 4 4 3 4 4 3 3 4|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 5| 4| 4| | |
DAY ON TEST | 3| 3| 3| 2| 5| 3| 3| 2| 9| 5| | |
| 1| 1| 1| 3| 0| 1| 1| 6| 8| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
.025G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
72HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large | + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + | 8 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + | 9 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + | 7 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + | 50 |
Lamina Propria, Inflammation, Acute | | 1 4.0|
Lamina Propria, Pigmentation | 4 4 4 4 3 4 3 4 | 50 3.8|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + | 7 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + | 7 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + | 50 |
Basophilic Focus | X X X X X X | 40 |
Clear Cell Focus | X | 5 |
Fatty Change | 3 2 2 | 9 2.7|
Hematocyst | | 1 |
Hepatodiaphragmatic Nodule | | 5 |
Inflammation, Granulomatous | | 10 1.7|
Mixed Cell Focus | | 1 |
Necrosis, Focal | | 1 2.0|
Bile Duct, Hyperplasia | 3 | 27 1.6|
__________________________________________________________________________|____________|
Mesentery | + + | 4 |
Inflammation, Chronic | | 1 3.0|
Fat, Necrosis, Focal | 3 | 2 3.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 50 |
Inflammation, Chronic, Diffuse | 4 | 1 4.0|
Acinus, Atrophy | | 4 1.8|
Acinus, Hyperplasia, Focal | 3 | 5 2.6|
Acinus, Hypertrophy, Focal | | 1 2.0|
Artery, Inflammation, Chronic Active | | 1 4.0|
Duct, Cyst | | 1 |
Duct, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + | 28 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + | 50 |
Acanthosis | 3 2 | 7 2.7|
Pigmentation | 1 | 9 1.8|
Ulcer | | 3 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 5| 4| 4| | |
DAY ON TEST | 3| 3| 3| 2| 5| 3| 3| 2| 9| 5| | |
| 1| 1| 1| 3| 0| 1| 1| 6| 8| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
.025G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
72HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + | 49 |
Edema | | 1 3.0|
Erosion, Focal | | 1 3.0|
Hyperplasia, Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + | 49 |
Cardiomyopathy | 1 2 2 | 17 1.7|
Inflammation, Chronic | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + | 50 |
Congestion | | 1 3.0|
Degeneration, Focal | | 1 2.0|
Degeneration | 3 | 5 3.2|
Hyperplasia, Focal | | 1 2.0|
Hyperplasia | 2 | 2 2.0|
Hypertrophy | | 1 1.0|
Necrosis | 3 | 1 3.0|
Vacuolization Cytoplasmic | | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + | 48 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + M | 38 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + | 50 |
Cyst | X | 1 |
Pars Distalis, Angiectasis | | 2 3.0|
Pars Distalis, Cyst | | 2 |
Pars Distalis, Hyperplasia, Focal | | 5 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + | 50 |
C-Cell, Hyperplasia | 2 | 2 2.0|
Follicular Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + | 9 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 5| 4| 4| | |
DAY ON TEST | 3| 3| 3| 2| 5| 3| 3| 2| 9| 5| | |
| 1| 1| 1| 3| 0| 1| 1| 6| 8| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
.025G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
72HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Suppurative | | 1 1.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Oviduct | + + | 3 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + | 50 |
Endometriosis | 4 | 1 4.0|
Hydrometra | | 1 2.0|
Endometrium, Hyperplasia, Cystic | 3 | 5 3.0|
Lumen, Hemorrhage | | 1 3.0|
Wall, Necrosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + | 7 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + | 50 |
Mediastinal, Congestion | | 1 2.0|
Mediastinal, Pigmentation, | | |
Hemosiderin | 3 | 2 3.0|
Pancreatic, Pigmentation | 4 4 4 3 | 33 3.9|
Renal, Congestion | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + | 46 |
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + | 50 |
Pigmentation | 3 4 4 4 4 4 4 1 | 45 3.6|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + | 50 |
Hematopoietic Cell Proliferation | | 2 3.5|
__________________________________________________________________________|____________|
Thymus | + + | 8 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + | 19 |
Hyperplasia, Cystic | | 1 4.0|
__________________________________________________________________________|____________|
Skin | + + | 9 |
Face, Abscess | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + | 6 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 5| 4| 4| | |
DAY ON TEST | 3| 3| 3| 2| 5| 3| 3| 2| 9| 5| | |
| 1| 1| 1| 3| 0| 1| 1| 6| 8| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
.025G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
72HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + | 50 |
Adenomatosis | | 1 2.0|
Congestion | | 2 2.5|
Interstitium, Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + | 6 |
Nasolacrimal Duct, Inflammation, | | |
Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 2 |
__________________________________________________________________________|____________|
Eye | + | 3 |
Lens, Mineralization | 4 | 2 3.5|
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + | 50 |
Nephropathy | 1 3 3 3 2 1 3 | 42 2.4|
Renal Tubule, Hyperplasia, Focal | | 5 1.4|
Renal Tubule, Pigmentation, | | |
Hemosiderin | 4 4 4 4 4 4 4 4 | 49 3.8|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
_____________________________________________________________________________________________________________________
| 7| 3| 6| 4| 4| 7| 7| 5| 5| 4| 7| 7| 6| 7| 4| 7| 7| 7| 6| 4| 7| 7| 5| 4| 4|
DAY ON TEST | 2| 8| 4| 5| 5| 3| 3| 8| 6| 5| 3| 3| 7| 3| 5| 3| 3| 3| 5| 2| 3| 3| 2| 8| 4|
| 0| 0| 7| 6| 4| 4| 4| 7| 9| 4| 4| 4| 2| 4| 4| 6| 6| 6| 3| 6| 5| 7| 4| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
72 VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + M + + +|
Parasite Metazoan | X 3 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + +|
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X |
Clear Cell Focus | X |
Congestion | |
Fatty Change | 3 2 2 3 4 2 4 2 4 3|
Fibrosis, Focal | |
Hepatodiaphragmatic Nodule | |
Inflammation, Chronic | |
Bile Duct, Hyperplasia | 2 2 2 3 3 3 2 3 3 3 2 2 2 2 3 2 3 |
__________________________________________________________________________|
Mesentery | + + + + + + |
Fat, Necrosis, Focal | 4 4 3 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Acinus, Atrophy | 2 2 2 3 2 |
Acinus, Hyperplasia, Focal | 3 3 |
Acinus, Hyperplasia | 3 |
Acinus, Vacuolization Cytoplasmic | 3 |
Artery, Hypertrophy | |
Artery, Inflammation, Chronic | |
Artery, Thrombosis | |
Serosa, Inflammation, Chronic | 3|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + +|
Serosa, Inflammation, Acute | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Necrosis | |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
_____________________________________________________________________________________________________________________
| 7| 3| 6| 4| 4| 7| 7| 5| 5| 4| 7| 7| 6| 7| 4| 7| 7| 7| 6| 4| 7| 7| 5| 4| 4|
DAY ON TEST | 2| 8| 4| 5| 5| 3| 3| 8| 6| 5| 3| 3| 7| 3| 5| 3| 3| 3| 5| 2| 3| 3| 2| 8| 4|
| 0| 0| 7| 6| 4| 4| 4| 7| 9| 4| 4| 4| 2| 4| 4| 6| 6| 6| 3| 6| 5| 7| 4| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
72 VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 1 1 1 3 3 3 3 1 1 3 2 1 2 3 2 2 2|
Fibrosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Vacuolization Cytoplasmic, Diffuse | 4 |
Vacuolization Cytoplasmic | 1 1 4|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis, Focal | |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia, Focal | 2 2 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + +|
Inflammation, Chronic | 3 2 2 2 2 2|
Duct, Cyst | X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
Inflammation, Suppurative | 3 2 4 3 3 3 4|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 2|
Seminiferous Tubule, Degeneration | 4 4 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + M + + M|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Congestion | 4 4|
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
_____________________________________________________________________________________________________________________
| 7| 3| 6| 4| 4| 7| 7| 5| 5| 4| 7| 7| 6| 7| 4| 7| 7| 7| 6| 4| 7| 7| 5| 4| 4|
DAY ON TEST | 2| 8| 4| 5| 5| 3| 3| 8| 6| 5| 3| 3| 7| 3| 5| 3| 3| 3| 5| 2| 3| 3| 2| 8| 4|
| 0| 0| 7| 6| 4| 4| 4| 7| 9| 4| 4| 4| 2| 4| 4| 6| 6| 6| 3| 6| 5| 7| 4| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
72 VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mediastinal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Plasma Cell | 4 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 3|
Pigmentation, Hemosiderin | 2 |
Pigmentation | 1 1 1 1 2 2 2 1 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 4 |
Pigmentation, Hemosiderin | |
Endothelium, Hyperplasia | 4 |
Red Pulp, Atrophy | |
__________________________________________________________________________|
Thymus | + + + + + + + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M M + + + + M M M|
Hyperplasia, Cystic | 3 |
Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Hyperkeratosis | |
Subcutaneous Tissue, Hemorrhage | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + +|
Lateral Ventricle, Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 3 3 2 3 4 |
Inflammation, Chronic | 2 |
Inflammation, Granulomatous | 2 2 2 2 |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
Interstitium, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + +|
Nasolacrimal Duct, Inflammation, | |
Chronic | 2 2 3|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
_____________________________________________________________________________________________________________________
| 7| 3| 6| 4| 4| 7| 7| 5| 5| 4| 7| 7| 6| 7| 4| 7| 7| 7| 6| 4| 7| 7| 5| 4| 4|
DAY ON TEST | 2| 8| 4| 5| 5| 3| 3| 8| 6| 5| 3| 3| 7| 3| 5| 3| 3| 3| 5| 2| 3| 3| 2| 8| 4|
| 0| 0| 7| 6| 4| 4| 4| 7| 9| 4| 4| 4| 2| 4| 4| 6| 6| 6| 3| 6| 5| 7| 4| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
72 VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Eye | + + + +|
Cataract | 4 |
__________________________________________________________________________|
Harderian Gland | + +|
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Necrosis, Focal | |
Nephropathy | 3 2 3 2 1 1 4 3 2 4 3 4 4 3 1 4 3 1 2|
Capsule, Developmental Malformation | |
Renal Tubule, Pigmentation, | |
Hemosiderin | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + +|
Wall, Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 4| 4| 7| 7| 7| 6| 5| 7| 7| 6| 6| 5| 7| 7| 6| 4| 4|
DAY ON TEST | 3| 3| 3| 2| 8| 3| 3| 0| 5| 5| 3| 3| 3| 7| 4| 3| 3| 5| 4| 7| 3| 3| 8| 5| 5|
| 7| 6| 6| 1| 1| 1| 6| 2| 6| 6| 7| 7| 7| 1| 9| 7| 7| 8| 2| 6| 7| 7| 5| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
72 VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + A + |
__________________________________________________________________________|
Intestine Large, Cecum | + A + |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | A + |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | A + |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + A + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + A + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + A + |
__________________________________________________________________________|
Intestine Small, Jejunum | A + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + |
Basophilic Focus | X X X X X X X X X X |
Clear Cell Focus | X X X X X X X X |
Congestion | 3 |
Fatty Change | 3 2 2 4 2 2 3 3 2 2 2 |
Fibrosis, Focal | 3 |
Hepatodiaphragmatic Nodule | X X X |
Inflammation, Chronic | |
Bile Duct, Hyperplasia | 3 3 3 1 1 3 2 2 2 1 3 2 2 2 2 2 2 |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis, Focal | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | 3 |
Acinus, Atrophy | 2 1 |
Acinus, Hyperplasia, Focal | 3 |
Acinus, Hyperplasia | 2 3 3 |
Acinus, Vacuolization Cytoplasmic | |
Artery, Hypertrophy | 4 4 |
Artery, Inflammation, Chronic | 4 |
Artery, Thrombosis | X |
Serosa, Inflammation, Chronic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + A + + + + + + + + |
Serosa, Inflammation, Acute | 4 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + A + + + + + + + + |
Acanthosis | 4 1 |
Ulcer | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + A + + + + + + + + |
Mineralization | 3 |
Necrosis | |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 4| 4| 7| 7| 7| 6| 5| 7| 7| 6| 6| 5| 7| 7| 6| 4| 4|
DAY ON TEST | 3| 3| 3| 2| 8| 3| 3| 0| 5| 5| 3| 3| 3| 7| 4| 3| 3| 5| 4| 7| 3| 3| 8| 5| 5|
| 7| 6| 6| 1| 1| 1| 6| 2| 6| 6| 7| 7| 7| 1| 9| 7| 7| 8| 2| 6| 7| 7| 5| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
72 VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + |
Cardiomyopathy | 2 1 2 3 1 4 2 3 2 1 1 2 3 4 1 4 1 |
Fibrosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + |
Cyst | |
Vacuolization Cytoplasmic, Diffuse | 3 |
Vacuolization Cytoplasmic | 3 1 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + M + + + |
Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + M |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + |
Pars Distalis, Angiectasis, Focal | |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + |
C-Cell, Hyperplasia | 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Preputial Gland | + A + + + |
Inflammation, Chronic | 3 3 2 |
Duct, Cyst | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + M + + + |
Hyperplasia, Focal | |
Inflammation, Suppurative | 3 3 2 4 3 2 1 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + |
Dilatation | 4 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + |
Interstitial Cell, Hyperplasia | 1 |
Seminiferous Tubule, Degeneration | 2 4 4 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + |
Mediastinal, Congestion | 4 |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 4| 4| 7| 7| 7| 6| 5| 7| 7| 6| 6| 5| 7| 7| 6| 4| 4|
DAY ON TEST | 3| 3| 3| 2| 8| 3| 3| 0| 5| 5| 3| 3| 3| 7| 4| 3| 3| 5| 4| 7| 3| 3| 8| 5| 5|
| 7| 6| 6| 1| 1| 1| 6| 2| 6| 6| 7| 7| 7| 1| 9| 7| 7| 8| 2| 6| 7| 7| 5| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
72 VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mediastinal, Pigmentation | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + M + + + + + + + + + + + + + + + |
Hyperplasia, Lymphoid | |
Pigmentation, Hemosiderin | |
Pigmentation | 1 2 2 1 2 1 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + |
Fibrosis | |
Pigmentation, Hemosiderin | 4 4 |
Endothelium, Hyperplasia | 4 |
Red Pulp, Atrophy | 3 |
__________________________________________________________________________|
Thymus | + + + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + |
Hyperplasia, Cystic | |
Hyperplasia | 4 |
__________________________________________________________________________|
Skin | + + + + + + + |
Cyst Epithelial Inclusion | X |
Hyperkeratosis | 4 |
Subcutaneous Tissue, Hemorrhage | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + |
Lateral Ventricle, Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + |
Congestion | 4 3 3 |
Inflammation, Chronic | |
Inflammation, Granulomatous | 1 2 2 2 1 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 |
Interstitium, Inflammation, Chronic | 3 |
__________________________________________________________________________|
Nose | A + |
Nasolacrimal Duct, Inflammation, | |
Chronic | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 4| 4| 7| 7| 7| 6| 5| 7| 7| 6| 6| 5| 7| 7| 6| 4| 4|
DAY ON TEST | 3| 3| 3| 2| 8| 3| 3| 0| 5| 5| 3| 3| 3| 7| 4| 3| 3| 5| 4| 7| 3| 3| 8| 5| 5|
| 7| 6| 6| 1| 1| 1| 6| 2| 6| 6| 7| 7| 7| 1| 9| 7| 7| 8| 2| 6| 7| 7| 5| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
72 VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 4 |
__________________________________________________________________________|
Harderian Gland | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + |
Congestion | 3 2 3 |
Necrosis, Focal | |
Nephropathy | 3 4 4 4 4 4 4 4 3 4 3 2 1 4 4 2 3 1 4 4 4 |
Capsule, Developmental Malformation | |
Renal Tubule, Pigmentation, | |
Hemosiderin | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + |
Wall, Inflammation, Suppurative | 4 |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
__________________________________________________________________________________________________________________________________
| 5| 5| 5| 5| 4| 7| 7| 6| 6| 4| | |
DAY ON TEST | 9| 7| 2| 2| 5| 3| 3| 8| 5| 5| | |
| 1| 0| 5| 2| 4| 6| 7| 6| 9| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
72 VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + | 13 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + + | 11 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + | 11 |
Parasite Metazoan | X | 4 2.5|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A + + | 11 |
Parasite Metazoan | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A A + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + + | 10 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + | 50 |
Basophilic Focus | X X X X X | 21 |
Clear Cell Focus | X | 10 |
Congestion | 3 | 2 3.0|
Fatty Change | 2 2 1 4 2 | 26 2.6|
Fibrosis, Focal | | 1 3.0|
Hepatodiaphragmatic Nodule | X | 4 |
Inflammation, Chronic | 1 | 1 1.0|
Bile Duct, Hyperplasia | 3 1 3 3 2 3 | 40 2.3|
__________________________________________________________________________|____________|
Mesentery | + | 7 |
Fat, Necrosis, Focal | | 5 3.4|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 50 |
Inflammation, Chronic | | 1 3.0|
Acinus, Atrophy | 2 | 8 2.0|
Acinus, Hyperplasia, Focal | | 3 3.0|
Acinus, Hyperplasia | 2 | 5 2.6|
Acinus, Vacuolization Cytoplasmic | | 1 3.0|
Artery, Hypertrophy | | 2 4.0|
Artery, Inflammation, Chronic | | 1 4.0|
Artery, Thrombosis | | 1 |
Serosa, Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + | 40 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + | 49 |
Serosa, Inflammation, Acute | | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + | 49 |
Acanthosis | 3 | 4 2.8|
Ulcer | 4 | 2 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
__________________________________________________________________________________________________________________________________
| 5| 5| 5| 5| 4| 7| 7| 6| 6| 4| | |
DAY ON TEST | 9| 7| 2| 2| 5| 3| 3| 8| 5| 5| | |
| 1| 0| 5| 2| 4| 6| 7| 6| 9| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
72 VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + | 49 |
Mineralization | | 1 3.0|
Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + | 50 |
Cardiomyopathy | 2 1 1 4 | 40 2.1|
Fibrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + | 50 |
Cyst | X | 1 |
Vacuolization Cytoplasmic, Diffuse | | 2 3.5|
Vacuolization Cytoplasmic | 1 | 7 1.7|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + | 49 |
Hyperplasia, Focal | 2 | 2 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + | 50 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + | 50 |
Pars Distalis, Angiectasis, Focal | 3 | 1 3.0|
Pars Distalis, Cyst | | 2 |
Pars Distalis, Hyperplasia, Focal | | 3 2.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + | 50 |
C-Cell, Hyperplasia | 2 | 4 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + | 17 |
Inflammation, Chronic | 2 | 10 2.3|
Duct, Cyst | | 1 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + | 49 |
Hyperplasia, Focal | 2 | 1 2.0|
Inflammation, Suppurative | 1 2 2 3 | 19 2.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
__________________________________________________________________________________________________________________________________
| 5| 5| 5| 5| 4| 7| 7| 6| 6| 4| | |
DAY ON TEST | 9| 7| 2| 2| 5| 3| 3| 8| 5| 5| | |
| 1| 0| 5| 2| 4| 6| 7| 6| 9| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
72 VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + | 50 |
Dilatation | | 1 4.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + | 50 |
Interstitial Cell, Hyperplasia | | 2 1.5|
Seminiferous Tubule, Degeneration | | 7 3.6|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + | 11 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + | 50 |
Mediastinal, Congestion | 2 3 | 5 3.4|
Mediastinal, Pigmentation | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + + + + + + | 49 |
Hyperplasia, Plasma Cell | 3 | 3 3.7|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + | 49 |
Hyperplasia, Lymphoid | | 2 3.0|
Pigmentation, Hemosiderin | | 1 2.0|
Pigmentation | 2 1 1 1 | 20 1.4|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + | 50 |
Fibrosis | | 1 4.0|
Pigmentation, Hemosiderin | | 2 4.0|
Endothelium, Hyperplasia | | 2 4.0|
Red Pulp, Atrophy | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + M + + | 17 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M + + | 9 |
Hyperplasia, Cystic | | 1 3.0|
Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Skin | + + M + | 20 |
Cyst Epithelial Inclusion | | 1 |
Hyperkeratosis | | 1 4.0|
Subcutaneous Tissue, Hemorrhage | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + | 13 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + | 50 |
Lateral Ventricle, Hemorrhage | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
__________________________________________________________________________________________________________________________________
| 5| 5| 5| 5| 4| 7| 7| 6| 6| 4| | |
DAY ON TEST | 9| 7| 2| 2| 5| 3| 3| 8| 5| 5| | |
| 1| 0| 5| 2| 4| 6| 7| 6| 9| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
72 VM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + | 50 |
Congestion | 3 3 3 | 12 3.1|
Inflammation, Chronic | | 1 2.0|
Inflammation, Granulomatous | 1 | 11 1.6|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 1 2.0|
Interstitium, Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + | 12 |
Nasolacrimal Duct, Inflammation, | | |
Chronic | | 4 2.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 5 |
Cataract | | 2 4.0|
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + | 50 |
Congestion | 3 | 4 2.8|
Necrosis, Focal | 4 | 1 4.0|
Nephropathy | 1 2 3 2 4 4 3 | 47 3.0|
Capsule, Developmental Malformation | X | 1 |
Renal Tubule, Pigmentation, | | |
Hemosiderin | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + | 50 |
Wall, Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
_____________________________________________________________________________________________________________________
| 2| 7| 4| 4| 4| 7| 1| 7| 6| 4| 7| 7| 6| 5| 4| 7| 7| 5| 4| 4| 7| 7| 7| 7| 4|
DAY ON TEST | 8| 2| 6| 5| 5| 2| 4| 2| 3| 5| 2| 3| 1| 9| 6| 3| 3| 6| 5| 3| 3| 3| 3| 3| 5|
| 6| 9| 1| 6| 4| 9| 7| 9| 9| 6| 9| 0| 1| 7| 3| 0| 0| 8| 4| 5| 0| 0| 0| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
.0125 G/ | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
KG 72LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + |
Periesophageal Tissue, Inflammation, | |
Suppurative | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + |
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + |
Lamina Propria, Pigmentation | 2 4 3 4 1 4 4 3 4 4 4 4 4 4 3 4 4 4 4 4 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + |
Basophilic Focus | X X |
Congestion | |
Fatty Change | 2 3 3 3 4 4 2 3 |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X X X X |
Bile Duct, Hyperplasia | 2 3 3 3 2 2 |
__________________________________________________________________________|
Mesentery | + + |
Artery, Inflammation, Chronic | |
Fat, Necrosis, Focal | 4 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + |
Acinus, Atrophy | 2 |
Artery, Inflammation, Chronic | |
Artery, Media, Hyperplasia | |
Duct, Ectasia, Multifocal | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + |
Acanthosis | 2 |
Pigmentation, Focal | |
Pigmentation | |
Ulcer | 4 4 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + |
Muscularis, Inflammation, Chronic | |
Serosa, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + |
Cardiomyopathy | 2 1 1 |
Inflammation, Chronic | 2 2 |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
_____________________________________________________________________________________________________________________
| 2| 7| 4| 4| 4| 7| 1| 7| 6| 4| 7| 7| 6| 5| 4| 7| 7| 5| 4| 4| 7| 7| 7| 7| 4|
DAY ON TEST | 8| 2| 6| 5| 5| 2| 4| 2| 3| 5| 2| 3| 1| 9| 6| 3| 3| 6| 5| 3| 3| 3| 3| 3| 5|
| 6| 9| 1| 6| 4| 9| 7| 9| 9| 6| 9| 0| 1| 7| 3| 0| 0| 8| 4| 5| 0| 0| 0| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
.0125 G/ | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
KG 72LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Artery, Myocardium, Inflammation, | |
Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + |
Degeneration | |
Hyperplasia, Focal | |
Hypertrophy, Focal | 1 |
Hypertrophy | 1 |
Vacuolization Cytoplasmic, Diffuse | 2 |
Vacuolization Cytoplasmic, Focal | |
Vacuolization Cytoplasmic | 2 1 3 1 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | M M M + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + |
Pars Distalis, Angiectasis, Focal | |
Pars Distalis, Hyperplasia, Focal | 2 2 3 3 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + |
C-Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + |
Inflammation, Chronic | 2 2 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Prostate | + + + + + + + + |
Inflammation, Chronic | 1 |
Inflammation, Suppurative | 2 4 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + |
Interstitial Cell, Hyperplasia | 2 1 2 |
Seminiferous Tubule, Degeneration | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + |
Lumbar, Hyperplasia, Lymphoid | |
Mediastinal, Congestion | |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
_____________________________________________________________________________________________________________________
| 2| 7| 4| 4| 4| 7| 1| 7| 6| 4| 7| 7| 6| 5| 4| 7| 7| 5| 4| 4| 7| 7| 7| 7| 4|
DAY ON TEST | 8| 2| 6| 5| 5| 2| 4| 2| 3| 5| 2| 3| 1| 9| 6| 3| 3| 6| 5| 3| 3| 3| 3| 3| 5|
| 6| 9| 1| 6| 4| 9| 7| 9| 9| 6| 9| 0| 1| 7| 3| 0| 0| 8| 4| 5| 0| 0| 0| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
.0125 G/ | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
KG 72LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mediastinal, Pigmentation | 1 |
Pancreatic, Pigmentation | 4 4 4 4 3 4 4 4 4 4 |
Renal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M M |
Hyperplasia, Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + M + + + + + + |
Hyperplasia, Lymphoid | |
Pigmentation | 4 1 2 4 2 4 2 4 3 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + |
Congestion | 3 |
Ectopic Tissue | X |
Hematopoietic Cell Proliferation | |
Hyperplasia, Re Cell | 3 |
Pigmentation, Hemosiderin | 4 |
__________________________________________________________________________|
Thymus | + + + + + M + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + M M M M + |
Hyperplasia, Cystic | |
Inflammation, Focal, Granulomatous | 4 |
Duct, Cyst | X |
Duct, Hemorrhage, Chronic | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + |
Cyst Epithelial Inclusion | |
Head, Inflammation, Acute | 3 |
Subcutaneous Tissue, Hemorrhage | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + |
Pons, Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + |
Congestion | 3 3 3 3 3 3 |
Hemorrhage | 3 |
Inflammation, Granulomatous | |
Alveolus, Inflammation, Acute | |
Perivascular, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + |
Nasolacrimal Duct, Inflammation, | |
Chronic | 2 3 |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
_____________________________________________________________________________________________________________________
| 2| 7| 4| 4| 4| 7| 1| 7| 6| 4| 7| 7| 6| 5| 4| 7| 7| 5| 4| 4| 7| 7| 7| 7| 4|
DAY ON TEST | 8| 2| 6| 5| 5| 2| 4| 2| 3| 5| 2| 3| 1| 9| 6| 3| 3| 6| 5| 3| 3| 3| 3| 3| 5|
| 6| 9| 1| 6| 4| 9| 7| 9| 9| 6| 9| 0| 1| 7| 3| 0| 0| 8| 4| 5| 0| 0| 0| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
.0125 G/ | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
KG 72LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Sinus, Inflammation, Chronic | |
__________________________________________________________________________|
Trachea | + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + |
Nephropathy | 4 2 4 1 2 3 3 3 4 4 1 2 3 2 2 3 4 4 2 |
Artery, Pelvis, Inflammation, Chronic| |
Renal Tubule, Hyperplasia, Focal | 1 |
Renal Tubule, Pigmentation, | |
Hemosiderin | 3 3 3 3 3 3 3 3 3 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + |
Concretion | 3 |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
_____________________________________________________________________________________________________________________
| 7| 6| 4| 4| 3| 7| 7| 6| 6| 4| 7| 7| 6| 6| 4| 7| 6| 4| 4| 4| 5| 4| 5| 4| 2|
DAY ON TEST | 3| 7| 8| 8| 6| 3| 3| 8| 3| 5| 3| 3| 8| 4| 5| 3| 8| 6| 5| 5| 8| 5| 6| 5| 9|
| 3| 2| 8| 2| 0| 3| 3| 7| 9| 4| 3| 3| 6| 8| 4| 3| 1| 7| 6| 4| 1| 6| 1| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
.0125 G/ | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
KG 72LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + M + + + M|
Periesophageal Tissue, Inflammation, | |
Suppurative | |
__________________________________________________________________________|
Intestine Large | + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + A|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + A|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + +|
Lamina Propria, Pigmentation | 4 3 3 3 3 4 4 3 3 4 4 4 4 4 2 3 3 2 3 1|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + A|
Basophilic Focus | X |
Congestion | |
Fatty Change | 1 3 4 3 1 2 |
Hematopoietic Cell Proliferation | 1 |
Hepatodiaphragmatic Nodule | X |
Bile Duct, Hyperplasia | 1 2 1 1 2 2 2 2 1 3 |
__________________________________________________________________________|
Mesentery | + + + + |
Artery, Inflammation, Chronic | 4 |
Fat, Necrosis, Focal | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + M|
Acinus, Atrophy | 3 |
Artery, Inflammation, Chronic | 4 |
Artery, Media, Hyperplasia | 4 |
Duct, Ectasia, Multifocal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + +|
Acanthosis | |
Pigmentation, Focal | 3 |
Pigmentation | 2 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + +|
Muscularis, Inflammation, Chronic | 3 |
Serosa, Inflammation, Chronic | 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + +|
Cardiomyopathy | 3 2 2 2 2 |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
_____________________________________________________________________________________________________________________
| 7| 6| 4| 4| 3| 7| 7| 6| 6| 4| 7| 7| 6| 6| 4| 7| 6| 4| 4| 4| 5| 4| 5| 4| 2|
DAY ON TEST | 3| 7| 8| 8| 6| 3| 3| 8| 3| 5| 3| 3| 8| 4| 5| 3| 8| 6| 5| 5| 8| 5| 6| 5| 9|
| 3| 2| 8| 2| 0| 3| 3| 7| 9| 4| 3| 3| 6| 8| 4| 3| 1| 7| 6| 4| 1| 6| 1| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
.0125 G/ | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
KG 72LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Artery, Myocardium, Inflammation, | |
Chronic | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Degeneration | 4 |
Hyperplasia, Focal | 4 2 2 |
Hypertrophy, Focal | |
Hypertrophy | 1 1 1 |
Vacuolization Cytoplasmic, Diffuse | |
Vacuolization Cytoplasmic, Focal | |
Vacuolization Cytoplasmic | 1 1 1 1 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + M|
__________________________________________________________________________|
Parathyroid Gland | + M M M + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis, Focal | 3 |
Pars Distalis, Hyperplasia, Focal | 1 2 2 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + A|
C-Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + M|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + +|
Inflammation, Chronic | 2 2 |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + +|
Inflammation, Chronic | |
Inflammation, Suppurative | 3 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | |
Seminiferous Tubule, Degeneration | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +|
Lumbar, Hyperplasia, Lymphoid | |
Mediastinal, Congestion | 3 4 |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
_____________________________________________________________________________________________________________________
| 7| 6| 4| 4| 3| 7| 7| 6| 6| 4| 7| 7| 6| 6| 4| 7| 6| 4| 4| 4| 5| 4| 5| 4| 2|
DAY ON TEST | 3| 7| 8| 8| 6| 3| 3| 8| 3| 5| 3| 3| 8| 4| 5| 3| 8| 6| 5| 5| 8| 5| 6| 5| 9|
| 3| 2| 8| 2| 0| 3| 3| 7| 9| 4| 3| 3| 6| 8| 4| 3| 1| 7| 6| 4| 1| 6| 1| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
.0125 G/ | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
KG 72LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mediastinal, Pigmentation | 3 3 |
Pancreatic, Pigmentation | 3 4 4 4 4 4 |
Renal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | M + M + + + + +|
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Pigmentation | 3 3 3 2 3 2 2 4 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + +|
Congestion | 4 |
Ectopic Tissue | |
Hematopoietic Cell Proliferation | 4 |
Hyperplasia, Re Cell | |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Thymus | + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M M + M|
Hyperplasia, Cystic | 3 |
Inflammation, Focal, Granulomatous | |
Duct, Cyst | |
Duct, Hemorrhage, Chronic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Head, Inflammation, Acute | |
Subcutaneous Tissue, Hemorrhage | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + +|
Pons, Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + +|
Congestion | 4 4 3 3 3 3 4 4 3 4|
Hemorrhage | |
Inflammation, Granulomatous | 2 |
Alveolus, Inflammation, Acute | |
Perivascular, Inflammation, Chronic | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + +|
Nasolacrimal Duct, Inflammation, | |
Chronic | 2 |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
_____________________________________________________________________________________________________________________
| 7| 6| 4| 4| 3| 7| 7| 6| 6| 4| 7| 7| 6| 6| 4| 7| 6| 4| 4| 4| 5| 4| 5| 4| 2|
DAY ON TEST | 3| 7| 8| 8| 6| 3| 3| 8| 3| 5| 3| 3| 8| 4| 5| 3| 8| 6| 5| 5| 8| 5| 6| 5| 9|
| 3| 2| 8| 2| 0| 3| 3| 7| 9| 4| 3| 3| 6| 8| 4| 3| 1| 7| 6| 4| 1| 6| 1| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
.0125 G/ | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
KG 72LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Sinus, Inflammation, Chronic | 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + A|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + |
__________________________________________________________________________|
Harderian Gland | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + A|
Nephropathy | 4 3 3 2 2 2 3 2 4 4 1 2 2 4 4 3 2 4 |
Artery, Pelvis, Inflammation, Chronic| 3 |
Renal Tubule, Hyperplasia, Focal | 2 |
Renal Tubule, Pigmentation, | |
Hemosiderin | 3 3 3 2 3 3 4 3 2 3 3 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + A + + + A + + + +|
Concretion | |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 7| 6| 5| | |
DAY ON TEST | 3| 0| 5| 0| 5| 3| 3| 3| 0| 0| | |
| 3| 8| 3| 8| 0| 3| 3| 3| 4| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
.0125 G/ | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
KG 72LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + | 18 |
Periesophageal Tissue, Inflammation, | | |
Suppurative | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + A | 18 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + A | 19 |
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + | 19 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 50 |
Lamina Propria, Pigmentation | 4 3 3 3 3 4 4 4 4 3 | 50 3.4|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A | 18 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + A | 18 |
__________________________________________________________________________|____________|
Liver | + + + + + | 31 |
Basophilic Focus | X X | 5 |
Congestion | 3 4 | 2 3.5|
Fatty Change | 2 3 2 3 | 18 2.7|
Hematopoietic Cell Proliferation | | 1 1.0|
Hepatodiaphragmatic Nodule | | 5 |
Bile Duct, Hyperplasia | 2 2 2 2 | 20 2.0|
__________________________________________________________________________|____________|
Mesentery | + + | 8 |
Artery, Inflammation, Chronic | | 1 4.0|
Fat, Necrosis, Focal | 4 3 | 5 3.8|
__________________________________________________________________________|____________|
Pancreas | + + + + | 22 |
Acinus, Atrophy | 2 | 3 2.3|
Artery, Inflammation, Chronic | | 1 4.0|
Artery, Media, Hyperplasia | | 1 4.0|
Duct, Ectasia, Multifocal | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + | 20 |
__________________________________________________________________________|____________|
Stomach | + + + + + | 23 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 23 |
Acanthosis | | 1 2.0|
Pigmentation, Focal | | 1 3.0|
Pigmentation | 3 | 2 2.5|
Ulcer | | 3 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 23 |
Muscularis, Inflammation, Chronic | | 1 3.0|
Serosa, Inflammation, Chronic | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 7| 6| 5| | |
DAY ON TEST | 3| 0| 5| 0| 5| 3| 3| 3| 0| 0| | |
| 3| 8| 3| 8| 0| 3| 3| 3| 4| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
.0125 G/ | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
KG 72LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + | 22 |
Cardiomyopathy | 2 3 | 10 2.0|
Inflammation, Chronic | | 2 2.0|
Artery, Myocardium, Inflammation, | | |
Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 50 |
Degeneration | | 1 4.0|
Hyperplasia, Focal | 2 2 | 5 2.4|
Hypertrophy, Focal | | 1 1.0|
Hypertrophy | | 4 1.0|
Vacuolization Cytoplasmic, Diffuse | | 1 2.0|
Vacuolization Cytoplasmic, Focal | 2 | 1 2.0|
Vacuolization Cytoplasmic | 2 1 | 12 1.3|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 50 |
Hyperplasia, Focal | 2 | 2 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + | 22 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M | 12 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 50 |
Pars Distalis, Angiectasis, Focal | | 1 3.0|
Pars Distalis, Hyperplasia, Focal | 3 | 10 2.4|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + | 20 |
C-Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + | 20 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + | 24 |
Inflammation, Chronic | | 4 2.0|
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Prostate | M + + + | 19 |
Inflammation, Chronic | | 1 1.0|
Inflammation, Suppurative | 2 | 5 2.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 7| 6| 5| | |
DAY ON TEST | 3| 0| 5| 0| 5| 3| 3| 3| 0| 0| | |
| 3| 8| 3| 8| 0| 3| 3| 3| 4| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
.0125 G/ | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
KG 72LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + | 25 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 50 |
Interstitial Cell, Hyperplasia | 2 | 4 1.8|
Seminiferous Tubule, Degeneration | 4 | 3 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + | 20 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 50 |
Lumbar, Hyperplasia, Lymphoid | 3 | 1 3.0|
Mediastinal, Congestion | | 2 3.5|
Mediastinal, Pigmentation | | 3 2.3|
Pancreatic, Pigmentation | 4 2 3 3 4 4 | 22 3.7|
Renal, Pigmentation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M + | 14 |
Hyperplasia, Plasma Cell | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 49 |
Hyperplasia, Lymphoid | 3 | 1 3.0|
Pigmentation | 4 2 3 | 22 2.8|
__________________________________________________________________________|____________|
Spleen | + + + + + | 29 |
Congestion | | 2 3.5|
Ectopic Tissue | | 1 |
Hematopoietic Cell Proliferation | | 1 4.0|
Hyperplasia, Re Cell | | 1 3.0|
Pigmentation, Hemosiderin | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + M M + | 17 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M M M | 10 |
Hyperplasia, Cystic | | 1 3.0|
Inflammation, Focal, Granulomatous | | 1 4.0|
Duct, Cyst | | 1 |
Duct, Hemorrhage, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + | 26 |
Cyst Epithelial Inclusion | | 1 |
Head, Inflammation, Acute | | 1 3.0|
Subcutaneous Tissue, Hemorrhage | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + | 19 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 7| 6| 5| | |
DAY ON TEST | 3| 0| 5| 0| 5| 3| 3| 3| 0| 0| | |
| 3| 8| 3| 8| 0| 3| 3| 3| 4| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
.0125 G/ | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
KG 72LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + | 20 |
Pons, Hemorrhage | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + | 30 |
Congestion | 3 4 3 3 4 4 | 22 3.4|
Hemorrhage | | 1 3.0|
Inflammation, Granulomatous | | 1 2.0|
Alveolus, Inflammation, Acute | 3 | 1 3.0|
Perivascular, Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + | 21 |
Nasolacrimal Duct, Inflammation, | | |
Chronic | 2 | 4 2.3|
Sinus, Inflammation, Chronic | | 2 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + | 19 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 5 |
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 49 |
Nephropathy | 3 4 2 3 1 4 2 4 3 | 46 2.8|
Artery, Pelvis, Inflammation, Chronic| | 1 3.0|
Renal Tubule, Hyperplasia, Focal | | 2 1.5|
Renal Tubule, Pigmentation, | | |
Hemosiderin | 3 3 3 2 2 | 27 2.8|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 48 |
Concretion | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
_____________________________________________________________________________________________________________________
| 7| 7| 5| 5| 4| 4| 7| 7| 6| 4| 4| 7| 7| 7| 5| 7| 7| 6| 5| 4| 7| 6| 5| 4| 4|
DAY ON TEST | 3| 3| 6| 1| 9| 5| 3| 2| 5| 5| 5| 3| 3| 1| 9| 3| 3| 3| 4| 5| 3| 4| 8| 6| 5|
| 3| 3| 2| 0| 2| 6| 3| 5| 3| 4| 6| 3| 3| 5| 5| 3| 3| 2| 1| 4| 4| 8| 8| 8| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
.025G/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
72HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + |
Colon, Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + M + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + |
Lamina Propria, Pigmentation | 4 4 4 3 4 4 4 4 3 4 4 4 3 3 4 3 3 4 4 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + |
Basophilic Focus | X X X X X X X X X |
Clear Cell Focus | X X X X |
Congestion | |
Fatty Change | 2 2 3 2 2 |
Hepatodiaphragmatic Nodule | X |
Inflammation, Acute, Focal | |
Necrosis | 2 |
Bile Duct, Hyperplasia | 3 3 1 2 2 3 3 1 3 3 2 1 1 2 2 2 |
Centrilobular, Degeneration | |
__________________________________________________________________________|
Mesentery | + + + |
Artery, Inflammation, Acute | 4 |
Fat, Necrosis, Focal | 3 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | 2 |
Acinus, Atrophy | 2 2 |
Acinus, Hyperplasia, Focal | 2 2 |
Acinus, Hyperplasia | |
Artery, Hypertrophy | 4 |
Artery, Inflammation, Chronic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + |
Acanthosis | 2 2 |
Pigmentation | 3 |
Ulcer | 4 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + |
Mineralization | 3 |
Necrosis | 4 |
__________________________________________________________________________|
Tongue | + |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
_____________________________________________________________________________________________________________________
| 7| 7| 5| 5| 4| 4| 7| 7| 6| 4| 4| 7| 7| 7| 5| 7| 7| 6| 5| 4| 7| 6| 5| 4| 4|
DAY ON TEST | 3| 3| 6| 1| 9| 5| 3| 2| 5| 5| 5| 3| 3| 1| 9| 3| 3| 3| 4| 5| 3| 4| 8| 6| 5|
| 3| 3| 2| 0| 2| 6| 3| 5| 3| 4| 6| 3| 3| 5| 5| 3| 3| 2| 1| 4| 4| 8| 8| 8| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
.025G/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
72HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + |
Cardiomyopathy | 2 2 1 3 2 3 3 2 2 2 1 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Focal | 2 2 2 |
Hypertrophy, Focal | |
Hypertrophy | |
Metaplasia, Osseous | |
Vacuolization Cytoplasmic, Focal | 1 3 |
Vacuolization Cytoplasmic | 1 4 1 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Focal | 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 3 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + M + + |
Hyperplasia | 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + M + + + + + |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia, Focal | 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + |
C-Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + |
Inflammation, Chronic | 3 |
Duct, Cyst | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + |
Inflammation, Subacute | |
Inflammation, Suppurative | 3 3 2 4 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + |
Seminiferous Tubule, Degeneration | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + |
Mediastinal, Congestion | |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
_____________________________________________________________________________________________________________________
| 7| 7| 5| 5| 4| 4| 7| 7| 6| 4| 4| 7| 7| 7| 5| 7| 7| 6| 5| 4| 7| 6| 5| 4| 4|
DAY ON TEST | 3| 3| 6| 1| 9| 5| 3| 2| 5| 5| 5| 3| 3| 1| 9| 3| 3| 3| 4| 5| 3| 4| 8| 6| 5|
| 3| 3| 2| 0| 2| 6| 3| 5| 3| 4| 6| 3| 3| 5| 5| 3| 3| 2| 1| 4| 4| 8| 8| 8| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
.025G/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
72HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mediastinal, Cyst | X |
Mediastinal, Hyperplasia, Lymphoid | |
Mediastinal, Pigmentation | |
Pancreatic, Cyst | |
Pancreatic, Pigmentation | 4 4 4 4 4 4 4 |
Renal, Congestion | 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + M + + M + |
Hyperplasia, Plasma Cell | 4 3 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + |
Congestion | |
Necrosis, Focal | 3 |
Pigmentation | 4 4 3 4 4 4 4 4 4 2 4 4 4 4 4 3 2 4 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + |
Cyst | X |
Fibrosis | 2 |
Hyperplasia, Nodular | |
Pigmentation, Hemosiderin | 4 |
Endothelium, Hyperplasia | |
__________________________________________________________________________|
Thymus | + + + + + M + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + + M + + |
Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + |
Hyperkeratosis | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + |
Adenomatosis | |
Congestion | 4 3 3 |
Hemorrhage | |
Inflammation, Granulomatous | |
Alveolar Epithelium, Pigmentation | 2 |
Perivascular, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + M + + + |
Nasolacrimal Duct, Inflammation, | |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
_____________________________________________________________________________________________________________________
| 7| 7| 5| 5| 4| 4| 7| 7| 6| 4| 4| 7| 7| 7| 5| 7| 7| 6| 5| 4| 7| 6| 5| 4| 4|
DAY ON TEST | 3| 3| 6| 1| 9| 5| 3| 2| 5| 5| 5| 3| 3| 1| 9| 3| 3| 3| 4| 5| 3| 4| 8| 6| 5|
| 3| 3| 2| 0| 2| 6| 3| 5| 3| 4| 6| 3| 3| 5| 5| 3| 3| 2| 1| 4| 4| 8| 8| 8| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
.025G/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
72HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Chronic | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + |
Mucosa, Pigmentation | 3 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + M |
Cataract | 3 |
Anterior Chamber, Inflammation, | |
Suppurative | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + |
Cyst | X |
Nephropathy | 4 4 2 4 4 4 4 4 3 4 4 2 4 4 3 4 4 3 3 3 |
Renal Tubule, Hyperplasia, Focal | 2 1 1 |
Renal Tubule, Pigmentation, | |
Hemosiderin | 3 3 3 3 3 3 3 3 4 3 4 3 3 4 3 3 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + |
Concretion | 3 |
Mucosa, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 4| 7| 6| 7| 6| 5| 7| 7| 6| 5| 4| 7| 4| 4| 3| 3| 6| 6| 6| 4| 4|
DAY ON TEST | 3| 2| 7| 4| 5| 3| 1| 3| 4| 1| 3| 3| 9| 6| 3| 3| 8| 7| 6| 2| 8| 6| 5| 5| 5|
| 5| 8| 7| 6| 6| 5| 0| 4| 4| 2| 5| 4| 4| 1| 3| 4| 9| 5| 0| 7| 0| 7| 3| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
.025G/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
72HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + |
Colon, Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + |
Lamina Propria, Pigmentation | 4 4 4 4 3 4 4 3 4 3 4 4 4 3 4 3 4 2 4 4 3 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + |
Basophilic Focus | X X X X X X X |
Clear Cell Focus | X X |
Congestion | 3 3 4 3 |
Fatty Change | 2 2 2 2 1 2 3 1 |
Hepatodiaphragmatic Nodule | |
Inflammation, Acute, Focal | 2 |
Necrosis | |
Bile Duct, Hyperplasia | 3 3 3 2 2 2 1 2 2 1 2 1 1 2 2 2 2 1 3 |
Centrilobular, Degeneration | 3 |
__________________________________________________________________________|
Mesentery | + |
Artery, Inflammation, Acute | |
Fat, Necrosis, Focal | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | |
Acinus, Atrophy | 3 |
Acinus, Hyperplasia, Focal | 3 4 |
Acinus, Hyperplasia | 3 3 |
Artery, Hypertrophy | |
Artery, Inflammation, Chronic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + |
Acanthosis | 2 |
Pigmentation | 1 1 1 2 |
Ulcer | 3 4 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + |
Mineralization | |
Necrosis | |
__________________________________________________________________________|
Tongue | |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 4| 7| 6| 7| 6| 5| 7| 7| 6| 5| 4| 7| 4| 4| 3| 3| 6| 6| 6| 4| 4|
DAY ON TEST | 3| 2| 7| 4| 5| 3| 1| 3| 4| 1| 3| 3| 9| 6| 3| 3| 8| 7| 6| 2| 8| 6| 5| 5| 5|
| 5| 8| 7| 6| 6| 5| 0| 4| 4| 2| 5| 4| 4| 1| 3| 4| 9| 5| 0| 7| 0| 7| 3| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
.025G/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
72HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + |
Cardiomyopathy | 1 2 2 2 2 1 2 1 2 3 3 2 3 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Focal | 2 3 |
Hypertrophy, Focal | |
Hypertrophy | 1 |
Metaplasia, Osseous | |
Vacuolization Cytoplasmic, Focal | |
Vacuolization Cytoplasmic | 1 1 1 2 1 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Focal | 2 1 2 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + M + + + + + + + M M + + + |
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia, Focal | 3 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + |
C-Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + |
Inflammation, Chronic | |
Duct, Cyst | X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Subacute | 2 |
Inflammation, Suppurative | 3 2 2 3 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + |
Seminiferous Tubule, Degeneration | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + M + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + |
Mediastinal, Congestion | 3 3 |
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 4| 7| 6| 7| 6| 5| 7| 7| 6| 5| 4| 7| 4| 4| 3| 3| 6| 6| 6| 4| 4|
DAY ON TEST | 3| 2| 7| 4| 5| 3| 1| 3| 4| 1| 3| 3| 9| 6| 3| 3| 8| 7| 6| 2| 8| 6| 5| 5| 5|
| 5| 8| 7| 6| 6| 5| 0| 4| 4| 2| 5| 4| 4| 1| 3| 4| 9| 5| 0| 7| 0| 7| 3| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
.025G/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
72HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mediastinal, Cyst | |
Mediastinal, Hyperplasia, Lymphoid | 3 |
Mediastinal, Pigmentation | 2 |
Pancreatic, Cyst | X |
Pancreatic, Pigmentation | 4 4 4 4 4 4 4 4 4 |
Renal, Congestion | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Plasma Cell | 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + |
Congestion | 4 |
Necrosis, Focal | |
Pigmentation | 4 3 3 1 4 2 2 4 2 1 4 4 4 4 4 4 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + |
Cyst | |
Fibrosis | |
Hyperplasia, Nodular | 4 |
Pigmentation, Hemosiderin | |
Endothelium, Hyperplasia | 4 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M M M M M M + + |
Hyperplasia | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + |
Hyperkeratosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + |
Adenomatosis | 3 |
Congestion | 3 3 3 4 3 4 3 3 3 4 |
Hemorrhage | 3 |
Inflammation, Granulomatous | 2 |
Alveolar Epithelium, Pigmentation | |
Perivascular, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + |
Nasolacrimal Duct, Inflammation, | |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 4| 7| 6| 7| 6| 5| 7| 7| 6| 5| 4| 7| 4| 4| 3| 3| 6| 6| 6| 4| 4|
DAY ON TEST | 3| 2| 7| 4| 5| 3| 1| 3| 4| 1| 3| 3| 9| 6| 3| 3| 8| 7| 6| 2| 8| 6| 5| 5| 5|
| 5| 8| 7| 6| 6| 5| 0| 4| 4| 2| 5| 4| 4| 1| 3| 4| 9| 5| 0| 7| 0| 7| 3| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
.025G/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
72HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Chronic | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + |
Mucosa, Pigmentation | 4 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
Cataract | |
Anterior Chamber, Inflammation, | |
Suppurative | 3 |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + |
Cyst | |
Nephropathy | 4 4 4 3 4 2 4 2 3 4 4 4 2 2 4 2 3 2 2 4 4 4 |
Renal Tubule, Hyperplasia, Focal | 2 2 |
Renal Tubule, Pigmentation, | |
Hemosiderin | 3 3 4 3 3 2 3 4 4 3 3 3 3 3 3 3 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + |
Concretion | |
Mucosa, Hyperplasia, Focal | 2 |
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 5| 5| 4| 4| 4| | |
DAY ON TEST | 3| 3| 2| 7| 5| 1| 0| 9| 6| 5| | |
| 4| 4| 5| 5| 6| 2| 6| 2| 2| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
.025G/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
72HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + | 23 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + | 22 |
Colon, Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + | 22 |
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + | 21 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + | 50 |
Lamina Propria, Pigmentation | 4 4 4 4 4 4 4 3 | 50 3.7|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + | 20 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + | 50 |
Basophilic Focus | X | 17 |
Clear Cell Focus | X | 7 |
Congestion | | 4 3.3|
Fatty Change | 2 2 3 2 | 17 2.1|
Hepatodiaphragmatic Nodule | | 1 |
Inflammation, Acute, Focal | | 1 2.0|
Necrosis | | 1 2.0|
Bile Duct, Hyperplasia | 2 2 2 1 1 2 | 41 2.0|
Centrilobular, Degeneration | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | | 4 |
Artery, Inflammation, Acute | | 1 4.0|
Fat, Necrosis, Focal | | 4 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 50 |
Inflammation, Chronic | | 1 2.0|
Acinus, Atrophy | | 3 2.3|
Acinus, Hyperplasia, Focal | | 4 2.8|
Acinus, Hyperplasia | | 2 3.0|
Artery, Hypertrophy | | 1 4.0|
Artery, Inflammation, Chronic | 4 | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + | 37 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + | 50 |
Acanthosis | 2 | 4 2.0|
Pigmentation | 2 | 6 1.7|
Ulcer | 2 | 6 3.2|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 69
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 5| 5| 4| 4| 4| | |
DAY ON TEST | 3| 3| 2| 7| 5| 1| 0| 9| 6| 5| | |
| 4| 4| 5| 5| 6| 2| 6| 2| 2| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
.025G/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
72HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Mineralization | | 1 3.0|
Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + | 50 |
Cardiomyopathy | 2 2 2 | 30 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + | 50 |
Hyperplasia, Focal | | 5 2.2|
Hypertrophy, Focal | 1 | 1 1.0|
Hypertrophy | | 1 1.0|
Metaplasia, Osseous | 2 | 1 2.0|
Vacuolization Cytoplasmic, Focal | | 2 2.0|
Vacuolization Cytoplasmic | 1 2 | 12 1.6|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + | 50 |
Hyperplasia, Focal | | 5 2.2|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + | 50 |
Hyperplasia | 3 | 2 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + | 44 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + | 49 |
Pars Distalis, Cyst | X | 1 |
Pars Distalis, Hyperplasia, Focal | 3 2 | 8 2.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + | 50 |
C-Cell, Hyperplasia | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + | 26 |
Inflammation, Chronic | 2 1 2 | 4 2.0|
Duct, Cyst | | 1 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 70
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 5| 5| 4| 4| 4| | |
DAY ON TEST | 3| 3| 2| 7| 5| 1| 0| 9| 6| 5| | |
| 4| 4| 5| 5| 6| 2| 6| 2| 2| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
.025G/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
72HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Subacute | | 1 2.0|
Inflammation, Suppurative | 2 | 11 2.5|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + | 50 |
Seminiferous Tubule, Degeneration | | 2 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 21 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + | 50 |
Mediastinal, Congestion | 4 | 3 3.3|
Mediastinal, Cyst | | 1 |
Mediastinal, Hyperplasia, Lymphoid | | 1 3.0|
Mediastinal, Pigmentation | | 1 2.0|
Pancreatic, Cyst | | 1 |
Pancreatic, Pigmentation | 4 4 4 4 4 | 21 4.0|
Renal, Congestion | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + | 47 |
Hyperplasia, Plasma Cell | | 4 3.8|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + | 50 |
Congestion | | 1 4.0|
Necrosis, Focal | | 1 3.0|
Pigmentation | 4 4 3 4 4 2 4 | 42 3.4|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + | 50 |
Cyst | | 1 |
Fibrosis | | 1 2.0|
Hyperplasia, Nodular | | 1 4.0|
Pigmentation, Hemosiderin | | 1 4.0|
Endothelium, Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + | 24 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + M + | 12 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + | 28 |
Hyperkeratosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + | 20 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 71
NTP Experiment-Test: 05043-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 2,4-DIAMINOPHENOL DIHYDROCHLORIDE Date: 04/29/97
Route: GAVAGE Time: 09:17:22
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 5| 5| 4| 4| 4| | |
DAY ON TEST | 3| 3| 2| 7| 5| 1| 0| 9| 6| 5| | |
| 4| 4| 5| 5| 6| 2| 6| 2| 2| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
.025G/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
72HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + | 50 |
Adenomatosis | | 1 3.0|
Congestion | 3 4 2 | 16 3.3|
Hemorrhage | | 1 3.0|
Inflammation, Granulomatous | | 1 2.0|
Alveolar Epithelium, Pigmentation | | 1 2.0|
Perivascular, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + | 21 |
Nasolacrimal Duct, Inflammation, | | |
Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + | 50 |
Mucosa, Pigmentation | | 2 3.5|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | | 3 |
Cataract | | 1 3.0|
Anterior Chamber, Inflammation, | | |
Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + | 50 |
Cyst | | 1 |
Nephropathy | 4 4 3 2 3 2 2 2 | 50 3.3|
Renal Tubule, Hyperplasia, Focal | 2 | 6 1.7|
Renal Tubule, Pigmentation, | | |
Hemosiderin | 3 3 4 4 3 2 3 3 | 42 3.1|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + | 50 |
Concretion | | 1 3.0|
Mucosa, Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
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