https://ntp.niehs.nih.gov/go/2389

TDMS Study 05057-01 Pathology Tables

NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97
Route: DOSED FEED                                                                                                 Time: 11:18:18
       Facility:  TSI Mason Research
       Chemical CAS #:  5982043-8
       Lock Date:  None
       Cage Range:  All
       Reasons For Removal:    All
       Removal Date Range:     All
       Treatment Groups:       Include All
Note:  Animals arranged according to CID number
                                                              Page   1
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 1| 7| 6| 4| 7| 1| 7| 7| 4| 1| 7| 1| 7| 4| 7| 6| 4| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 0| 6| 8| 3| 4| 6| 3| 8| 2| 1| 6| 8| 3| 8| 3| 6| 3| 4| 6| 2| 3|             
                                           | 5| 5| 6| 6| 1| 4| 3| 5| 7| 4| 5| 2| 8| 0| 4| 3| 5| 3| 1| 4| 5| 5| 4| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    UNTREATE                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    D 61UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +        +  +     M     +  +        +     +     +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +        +  +     +     +  +        +     M     +  +     +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
      Hepatocellular Carcinoma             |                                                       X                  |             
      Leukemia Mononuclear                 |                                                 X     X                 X|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                        +                                 |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Acinus, Adenoma                      |          X                          X                                    |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
      Leukemia Mononuclear                 |                                                       X                 X|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
      Adenoma                              |                      X                                                   |             
      Leukemia Mononuclear                 |                                                       X                 X|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
      Leukemia Mononuclear                 |                                                       X                 X|             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
      Adenoma                              |                               X                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +        +  +     M     +  M        +     M     +  +     +  +|             
      Adenoma                              |                                     X                                    |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
      Pars Distalis, Adenoma               | X  X  X  X  X        X  X           X                 X        X        X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 1| 7| 6| 4| 7| 1| 7| 7| 4| 1| 7| 1| 7| 4| 7| 6| 4| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 0| 6| 8| 3| 4| 6| 3| 8| 2| 1| 6| 8| 3| 8| 3| 6| 3| 4| 6| 2| 3|             
                                           | 5| 5| 6| 6| 1| 4| 3| 5| 7| 4| 5| 2| 8| 0| 4| 3| 5| 3| 1| 4| 5| 5| 4| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    UNTREATE                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    D 61UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Adenoma, Multiple     |                               X                 X                        |             
      Pars Distalis, Carcinoma             |                                        X                                 |             
      Pars Distalis, Leukemia Mononuclear  |                                                                         X|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      C-Cell, Adenoma                      | X        X                    X                                X         |             
      C-Cell, Carcinoma                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +        +  +     M     +  +        +     +     +  +     +  +|             
      Adenoma                              |                                                                X     X   |             
      Bilateral, Adenoma                   |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
      Leukemia Mononuclear                 |                                                                         X|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Polyp Stromal                        |                                     X                                X   |             
      Cervix, Leukemia Mononuclear         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
      Mediastinal, Carcinoma, Metastatic,  |                                                                          |             
           Thyroid Gland                   |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |                                                       X                 X|             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
      Renal, Leukemia Mononuclear          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +        +  M     +     +  +        +     +     +  +     +  +|             
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |             
          Gland                            |                                                                          |             
      Leukemia Mononuclear                 |                                                       X                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
      Leukemia Mononuclear                 |                                                       X                 X|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
      Leukemia Mononuclear                 |                                                 X     X                 X|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +        M  +     +     M  +        +     +     +  +     +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 1| 7| 6| 4| 7| 1| 7| 7| 4| 1| 7| 1| 7| 4| 7| 6| 4| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 0| 6| 8| 3| 4| 6| 3| 8| 2| 1| 6| 8| 3| 8| 3| 6| 3| 4| 6| 2| 3|             
                                           | 5| 5| 6| 6| 1| 4| 3| 5| 7| 4| 5| 2| 8| 0| 4| 3| 5| 3| 1| 4| 5| 5| 4| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    UNTREATE                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    D 61UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Adenocarcinoma                       |                                                                          |             
      Adenoma                              |                                                                          |             
      Fibroadenoma                         |          X  X                                   X     X     X        X   |             
      Fibroadenoma, Multiple               |    X                    X     X                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
      Basal Cell Carcinoma                 |                                                 X                        |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Lipoma          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
      Carcinoma, Metastatic, Pituitary     |                                                                          |             
          Gland                            |                                        X                                 |             
      Leukemia Mononuclear                 |                                                                          |             
      Oligodendroglioma Malignant          |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                +         |             
      Neoplasm NOS                         |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |             
          Gland                            |                                                                          |             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                                                          |             
      Leukemia Mononuclear                 |                                                       X                 X|             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Nose                            |             X                                                            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
      Leukemia Mononuclear                 |                                                                         X|             
      Squamous Cell Carcinoma              |             X                                                            |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      Fibroma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |             +           +                                                |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                         +                                                |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 1| 7| 6| 4| 7| 1| 7| 7| 4| 1| 7| 1| 7| 4| 7| 6| 4| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 0| 6| 8| 3| 4| 6| 3| 8| 2| 1| 6| 8| 3| 8| 3| 6| 3| 4| 6| 2| 3|             
                                           | 5| 5| 6| 6| 1| 4| 3| 5| 7| 4| 5| 2| 8| 0| 4| 3| 5| 3| 1| 4| 5| 5| 4| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    UNTREATE                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    D 61UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
      Leukemia Mononuclear                 |                                                       X                 X|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
      Leukemia Mononuclear                 |                                                 X     X                 X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 6| 4| 7| 1| 6| 4| 4| 7| 7| 7| 7| 6| 7| 7| 1| 7| 6| 1| 7| 7| 4| 7|             
                             DAY ON TEST   | 3| 6| 3| 9| 4| 3| 8| 5| 6| 2| 3| 3| 2| 1| 1| 3| 3| 8| 0| 9| 8| 3| 3| 6| 3|             
                                           | 5| 4| 6| 9| 7| 5| 3| 8| 4| 2| 5| 6| 3| 0| 2| 5| 5| 3| 0| 2| 2| 5| 5| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATE                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    D 61UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +     +  +  +  +     +     A  +  +  +  +  +  +  +     +  +     +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
      Leukemia Mononuclear                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +     +  +  +  +     +     +  +  M  +  +  +  +  +     +  +     +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
      Leukemia Mononuclear                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +     +  +  +  +     +     A  +  +  +  +  +  +  +     +  +     +  +     +|             
                                            __________________________________________________________________________|             
   Liver                                   | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
      Hepatocellular Carcinoma             |                                                                          |             
      Leukemia Mononuclear                 |          X  X                    X              X     X  X               |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +                                                            |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
      Acinus, Adenoma                      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
      Leukemia Mononuclear                 |          X  X                                         X  X               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |          X                       X                       X               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
      Leukemia Mononuclear                 |          X                       X                       X               |             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              |                                  X                                       |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
      Pars Distalis, Adenoma               | X     X     X  X     X        X     X  X  X           X        X  X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 6| 4| 7| 1| 6| 4| 4| 7| 7| 7| 7| 6| 7| 7| 1| 7| 6| 1| 7| 7| 4| 7|             
                             DAY ON TEST   | 3| 6| 3| 9| 4| 3| 8| 5| 6| 2| 3| 3| 2| 1| 1| 3| 3| 8| 0| 9| 8| 3| 3| 6| 3|             
                                           | 5| 4| 6| 9| 7| 5| 3| 8| 4| 2| 5| 6| 3| 0| 2| 5| 5| 3| 0| 2| 2| 5| 5| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATE                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    D 61UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Adenoma, Multiple     |                                                                          |             
      Pars Distalis, Carcinoma             |                                                                          |             
      Pars Distalis, Leukemia Mononuclear  |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
      C-Cell, Adenoma                      |                      X                 X     X                           |             
      C-Cell, Carcinoma                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | M     +  +  +  +     +     +  +  +  +  +  M  +  +     +  +     +  +     +|             
      Adenoma                              |                      X        X                                          |             
      Bilateral, Adenoma                   |                                                       X                  |             
                                            __________________________________________________________________________|             
   Ovary                                   | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
      Leukemia Mononuclear                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Uterus                                  | +     M  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
      Leukemia Mononuclear                 |          X                                                               |             
      Polyp Stromal                        |                                     X                                    |             
      Cervix, Leukemia Mononuclear         |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
      Leukemia Mononuclear                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
      Mediastinal, Carcinoma, Metastatic,  |                                                                          |             
           Thyroid Gland                   |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |          X                                               X               |             
      Pancreatic, Leukemia Mononuclear     |          X  X                                         X                  |             
      Renal, Leukemia Mononuclear          |             X                                            X               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |             
          Gland                            |                                                                          |             
      Leukemia Mononuclear                 |          X  X                    X                    X                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     M  +     +|             
      Leukemia Mononuclear                 |          X  X                    X                    X  X               |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
      Leukemia Mononuclear                 |          X  X                    X              X     X  X               |             
                                            __________________________________________________________________________|             
   Thymus                                  | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
      Leukemia Mononuclear                 |          X                       X                       X               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +     +  +  M  +     +     M  +  +  +  +  +  +  +     +  +     +  +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 6| 4| 7| 1| 6| 4| 4| 7| 7| 7| 7| 6| 7| 7| 1| 7| 6| 1| 7| 7| 4| 7|             
                             DAY ON TEST   | 3| 6| 3| 9| 4| 3| 8| 5| 6| 2| 3| 3| 2| 1| 1| 3| 3| 8| 0| 9| 8| 3| 3| 6| 3|             
                                           | 5| 4| 6| 9| 7| 5| 3| 8| 4| 2| 5| 6| 3| 0| 2| 5| 5| 3| 0| 2| 2| 5| 5| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATE                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    D 61UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Adenocarcinoma                       |                                                                          |             
      Adenoma                              |                X                                      X                  |             
      Fibroadenoma                         | X              X              X     X     X  X           X               |             
      Fibroadenoma, Multiple               |       X  X                                                               |             
                                            __________________________________________________________________________|             
   Skin                                    | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
      Basal Cell Carcinoma                 |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                                        X                                 |             
      Subcutaneous Tissue, Lipoma          |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
      Carcinoma, Metastatic, Pituitary     |                                                                          |             
          Gland                            |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
      Oligodendroglioma Malignant          |                            X                                             |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
      Neoplasm NOS                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |             
          Gland                            |                                                                          |             
      Alveolar/Bronchiolar Adenoma         |                      X                                                   |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |          X                                                               |             
      Leukemia Mononuclear                 |          X  X                    X                    X  X               |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Nose                            |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
      Squamous Cell Carcinoma              |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |       +                                                                  |             
      Fibroma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +     +  +           +           +     +  +                              |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +     +  +           +           +     +                                 |             
      Adenoma                              |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 6| 4| 7| 1| 6| 4| 4| 7| 7| 7| 7| 6| 7| 7| 1| 7| 6| 1| 7| 7| 4| 7|             
                             DAY ON TEST   | 3| 6| 3| 9| 4| 3| 8| 5| 6| 2| 3| 3| 2| 1| 1| 3| 3| 8| 0| 9| 8| 3| 3| 6| 3|             
                                           | 5| 4| 6| 9| 7| 5| 3| 8| 4| 2| 5| 6| 3| 0| 2| 5| 5| 3| 0| 2| 2| 5| 5| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATE                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    D 61UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
      Leukemia Mononuclear                 |          X  X                                                            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +  +  +  +     +     A  +  +  +  +  +  +  +     +  +     +  +     +|             
      Leukemia Mononuclear                 |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
      Leukemia Mononuclear                 |          X  X                    X              X     X  X               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 5| 7| 4| 7| 6| 6| 7| 4| 1| 7| 4| 1| 7| 7| 6| 1|              |            |
                             DAY ON TEST   | 3| 3| 0| 5| 8| 3| 6| 3| 5| 0| 3| 6| 8| 3| 0| 8| 3| 3| 5| 8|              |            |
                                           | 5| 5| 2| 0| 2| 5| 4| 6| 8| 0| 5| 4| 3| 5| 9| 3| 5| 5| 8| 2|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |     A      |
    UNTREATE                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |     L      |
    D 61UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +     +  +  A  +        +  +     +  +  +                  |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +     +  +  A  M        +  +     +  +  +                  |  48        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +     +  +  A  +        +  +     +  +  +                  |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +     +  +  A  +        +  +     +  +  +                  |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +     +  +  A  +        +  +     +  +  +                  |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +     +  +  A  +        +  +     +  +  +                  |  47        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  50        |
      Hepatocellular Carcinoma             |                                                                          |          1 |
      Leukemia Mononuclear                 |       X  X                                      X  X  X                  |         14 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                 +                        |   3        |
      Leukemia Mononuclear                 |                                                 X                        |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +     +  +  A  +        +  +     +  +  +                  |  49        |
      Leukemia Mononuclear                 |                                                 X                        |          1 |
      Acinus, Adenoma                      |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  50        |
      Leukemia Mononuclear                 |                                                 X                        |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  50        |
      Leukemia Mononuclear                 |       X  X                                      X     X                  |         10 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  50        |
      Adenoma                              |                                                                          |          1 |
      Leukemia Mononuclear                 |          X                                            X                  |          7 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +     +  +  M  +        +  +     +  +  +                  |  49        |
      Leukemia Mononuclear                 |          X                                            X                  |          7 |
      Pheochromocytoma Malignant           |                                                 X                        |          1 |
      Pheochromocytoma Benign              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  10                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 5| 7| 4| 7| 6| 6| 7| 4| 1| 7| 4| 1| 7| 7| 6| 1|              |            |
                             DAY ON TEST   | 3| 3| 0| 5| 8| 3| 6| 3| 5| 0| 3| 6| 8| 3| 0| 8| 3| 3| 5| 8|              |            |
                                           | 5| 5| 2| 0| 2| 5| 4| 6| 8| 0| 5| 4| 3| 5| 9| 3| 5| 5| 8| 2|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |     A      |
    UNTREATE                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |     L      |
    D 61UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +     +  +  +  M        +  +     +  +  +                  |  46        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +     +  +  A  +        +  +     +  +  +                  |  49        |
      Pars Distalis, Adenoma               |    X     X  X  X        X     X                    X  X                  |         31 |
      Pars Distalis, Adenoma, Multiple     |                                                                          |          2 |
      Pars Distalis, Carcinoma             |                                                                          |          1 |
      Pars Distalis, Leukemia Mononuclear  |                                                 X     X                  |          3 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  50        |
      Leukemia Mononuclear                 |                                                 X                        |          1 |
      C-Cell, Adenoma                      |                      X  X                                                |          9 |
      C-Cell, Carcinoma                    |                            X                                             |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  47        |
      Adenoma                              |                                        X           X                     |          6 |
      Bilateral, Adenoma                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  50        |
      Leukemia Mononuclear                 |          X                                      X     X                  |          5 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +     +  +  A  +        +  +     +  +  +                  |  48        |
      Leukemia Mononuclear                 |                                                 X                        |          2 |
      Polyp Stromal                        |                                                       X                  |          4 |
      Cervix, Leukemia Mononuclear         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  50        |
      Leukemia Mononuclear                 |                                                       X                  |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  50        |
      Mediastinal, Carcinoma, Metastatic,  |                                                                          |            |
           Thyroid Gland                   |                            X                                             |          1 |
      Mediastinal, Leukemia Mononuclear    |          X                                      X     X                  |          7 |
      Pancreatic, Leukemia Mononuclear     |          X                                      X                        |          5 |
      Renal, Leukemia Mononuclear          |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  49        |
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |            |
          Gland                            |                                           X                              |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  11                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 5| 7| 4| 7| 6| 6| 7| 4| 1| 7| 4| 1| 7| 7| 6| 1|              |            |
                             DAY ON TEST   | 3| 3| 0| 5| 8| 3| 6| 3| 5| 0| 3| 6| 8| 3| 0| 8| 3| 3| 5| 8|              |            |
                                           | 5| 5| 2| 0| 2| 5| 4| 6| 8| 0| 5| 4| 3| 5| 9| 3| 5| 5| 8| 2|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |     A      |
    UNTREATE                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |     L      |
    D 61UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |                                                 X     X                  |          7 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  49        |
      Leukemia Mononuclear                 |       X  X                                      X     X                  |         11 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  50        |
      Leukemia Mononuclear                 |       X  X                                      X  X  X                  |         14 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +     +  +  M  +        +  +     +  +  +                  |  47        |
      Leukemia Mononuclear                 |          X                                      X     X                  |          7 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  48        |
      Adenocarcinoma                       |                                           X                              |          1 |
      Adenoma                              |    X                                                                     |          3 |
      Fibroadenoma                         |    X        X  X     X        X        X                                 |         19 |
      Fibroadenoma, Multiple               | X                       X                       X     X                  |          9 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +     +  M  +  +        +  +     M  +  +                  |  48        |
      Basal Cell Carcinoma                 |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |                                                                          |          1 |
      Subcutaneous Tissue, Lipoma          |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                 +                        |   1        |
      Leukemia Mononuclear                 |                                                 X                        |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  50        |
      Carcinoma, Metastatic, Pituitary     |                                                                          |            |
          Gland                            |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                       X                  |          1 |
      Oligodendroglioma Malignant          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
      Neoplasm NOS                         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  50        |
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |            |
          Gland                            |                                           X                              |          1 |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          1 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  12                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 5| 7| 4| 7| 6| 6| 7| 4| 1| 7| 4| 1| 7| 7| 6| 1|              |            |
                             DAY ON TEST   | 3| 3| 0| 5| 8| 3| 6| 3| 5| 0| 3| 6| 8| 3| 0| 8| 3| 3| 5| 8|              |            |
                                           | 5| 5| 2| 0| 2| 5| 4| 6| 8| 0| 5| 4| 3| 5| 9| 3| 5| 5| 8| 2|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |     A      |
    UNTREATE                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |     L      |
    D 61UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
          Multiple                         |                                                                          |          1 |
      Leukemia Mononuclear                 |       X  X                                      X     X                  |         11 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Nose                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  50        |
      Leukemia Mononuclear                 |          X                                                               |          2 |
      Squamous Cell Carcinoma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     | +                                                                        |   2        |
      Fibroma                              | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Eye                                     |    +                    +     +                                          |  12        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |    +                          +                                          |   9        |
      Adenoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +     +  +  A  +        +  +     +  +  +                  |  49        |
      Leukemia Mononuclear                 |       X  X                                      X     X                  |          8 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +     +  +  A  +        +  +     +  +  +                  |  48        |
      Leukemia Mononuclear                 |                                                 X                        |          2 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  50        |
      Leukemia Mononuclear                 |       X  X                                      X  X  X                  |         14 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  13                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 4| 7| 7| 6| 1| 4| 7| 4| 1| 6| 1| 7| 6| 6| 4| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 1| 4| 6| 3| 3| 6| 8| 6| 3| 6| 8| 1| 8| 3| 8| 2| 6| 3| 3| 3| 1| 1|             
                                           | 4| 4| 4| 3| 4| 4| 4| 4| 8| 3| 4| 4| 4| 3| 1| 3| 4| 6| 8| 4| 5| 5| 4| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.5%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    61LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  M  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | M  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +     +  +  +        +        +     M  +  +     +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +     +  +  +        M        +     +  +  +     +  +  +  +  A|             
      Leukemia Mononuclear                 |                                                       X                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  A     +  +  +        +        +     +  +  +     M  +  +  +  A|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
      Carcinoma, Metastatic, Ovary         |                                                                          |             
      Hepatocellular Adenoma               |       X                                                                  |             
      Leukemia Mononuclear                 |             X        X  X                 X        X  X              X  X|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Carcinoma, Metastatic, Ovary         |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                             X        X  X                  |             
      Acinus, Adenoma                      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                    X  X                  |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                    X                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                             X        X  X              X  X|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                    X  X                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +     +  +  +        +        M     +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                    X  X                  |             
      Pheochromocytoma Benign              |       X                                                                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  M  +  M     +  +  +        +        M     +  +  +     +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  M  +  +|             
      Pars Distalis, Adenoma               | X     X           X              X              X     X     X  X     X   |             
      Pars Distalis, Adenoma, Multiple     |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 4| 7| 7| 6| 1| 4| 7| 4| 1| 6| 1| 7| 6| 6| 4| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 1| 4| 6| 3| 3| 6| 8| 6| 3| 6| 8| 1| 8| 3| 8| 2| 6| 3| 3| 3| 1| 1|             
                                           | 4| 4| 4| 3| 4| 4| 4| 4| 8| 3| 4| 4| 4| 3| 1| 3| 4| 6| 8| 4| 5| 5| 4| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.5%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    61LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Leukemia Mononuclear  |                                                       X              X   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
      C-Cell, Adenoma                      |                                  X        X                 X            |             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +     +  +  +        +        +     +  M  +     +  +  +  +  +|             
      Adenoma                              |                                  X                                       |             
      Leukemia Mononuclear                 |                                                       X                  |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
      Granulosa Cell Tumor Benign          |                                  X                                       |             
      Leukemia Mononuclear                 |                                                       X                  |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
      Polyp Stromal                        |                   X                                X        X           X|             
      Polyp Stromal, Multiple              |                                                                          |             
      Sarcoma Stromal                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  A|             
      Leukemia Mononuclear                 |                                                    X  X              X   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
      Mediastinal, Carcinoma, Metastatic,  |                                                                          |             
           Ovary                           |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |                                                    X  X              X   |             
      Pancreatic, Leukemia Mononuclear     |                                                    X                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                             X        X  X              X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                                      X  X              X   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  A|             
      Leukemia Mononuclear                 |             X     X  X  X                 X           X              X   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +     +  +  M        +        +     +  +  +     +  +  M  +  +|             
      Leukemia Mononuclear                 |             X                                      X  X              X  X|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  +  +     +  +  +        +        +     M  +  +     +  +  M  +  +|             
      Fibroadenoma                         |    X     X                                         X                     |             
      Fibroadenoma, Multiple               |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 4| 7| 7| 6| 1| 4| 7| 4| 1| 6| 1| 7| 6| 6| 4| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 1| 4| 6| 3| 3| 6| 8| 6| 3| 6| 8| 1| 8| 3| 8| 2| 6| 3| 3| 3| 1| 1|             
                                           | 4| 4| 4| 3| 4| 4| 4| 4| 8| 3| 4| 4| 4| 3| 1| 3| 4| 6| 8| 4| 5| 5| 4| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.5%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    61LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Carcinoma Adenosquamous              |                                                                          |             
      Keratoacanthoma                      |                                                                          |             
      Subcutaneous Tissue, Fibroma         |             X           X                                                |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Carcinoma Adenosquamous, Metastatic, |                                                                          |             
           Skin                            |                                                                          |             
      Leukemia Mononuclear                 |             X        X  X                 X        X  X              X  X|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |    +                                                                     |             
                                            __________________________________________________________________________|             
   Eye                                     |    +     +        +  +                    I        +                     |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |          +        +  +                             +                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                             X        X  X                 X|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |             X     X  X  X                 X        X  X              X  X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
 _____________________________________________________________________________________________________________________              
                                           | 7| 1| 4| 7| 7| 7| 1| 1| 7| 6| 7| 4| 4| 7| 6| 7| 7| 7| 6| 5| 7| 7| 7| 1| 4|             
                             DAY ON TEST   | 3| 8| 6| 3| 1| 3| 8| 8| 3| 7| 3| 6| 6| 3| 6| 3| 3| 3| 8| 4| 3| 3| 3| 8| 7|             
                                           | 5| 3| 4| 4| 0| 5| 2| 3| 5| 2| 5| 4| 4| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 2| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.5%                                   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    61LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +        +  +  +        +  +  +        +  +  +  +  +  +  +  M  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +        +  +  +        +  +  +        +  +  +  +  +  +  +  M  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Liver                                   | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
      Carcinoma, Metastatic, Ovary         |                                                                          |             
      Hepatocellular Adenoma               |                                                                          |             
      Leukemia Mononuclear                 |             X              X                                   X  X      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                         +|             
      Carcinoma, Metastatic, Ovary         |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |             X                                                            |             
      Acinus, Adenoma                      |                X                                                         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +        +  +  +        +  +  +        +  +  +  +  +  M  +  +  +  +     M|             
      Leukemia Mononuclear                 |             X                                                            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |             X              X                                             |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                            X                                   X         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +        +  +  +        +  +  +        +  +  +  +  +  +  I  +  +  +     +|             
      Leukemia Mononuclear                 |                            X                                   X         |             
      Pheochromocytoma Benign              |                                                 X              X         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +        +  +  +        +  +  +        +  +  +  M  +  +  M  M  M  +     +|             
      Adenoma                              |                                                       X                  |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
      Pars Distalis, Adenoma               | X              X        X  X  X        X     X  X  X  X     X  X  X     X|             
      Pars Distalis, Adenoma, Multiple     |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
 _____________________________________________________________________________________________________________________              
                                           | 7| 1| 4| 7| 7| 7| 1| 1| 7| 6| 7| 4| 4| 7| 6| 7| 7| 7| 6| 5| 7| 7| 7| 1| 4|             
                             DAY ON TEST   | 3| 8| 6| 3| 1| 3| 8| 8| 3| 7| 3| 6| 6| 3| 6| 3| 3| 3| 8| 4| 3| 3| 3| 8| 7|             
                                           | 5| 3| 4| 4| 0| 5| 2| 3| 5| 2| 5| 4| 4| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 2| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.5%                                   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    61LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Leukemia Mononuclear  |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
      C-Cell, Adenoma                      |                                                    X                     |             
      Follicular Cell, Adenoma             |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +        +  +  +        +  +  +        M  +  +  +  +  +  +  +  +  +     +|             
      Adenoma                              |          X  X                                                     X      |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
      Carcinoma                            |                                                                          |             
      Granulosa Cell Tumor Benign          |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
      Polyp Stromal                        |                                                                   X      |             
      Polyp Stromal, Multiple              |                                                                          |             
      Sarcoma Stromal                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
      Mediastinal, Carcinoma, Metastatic,  |                                                                          |             
           Ovary                           |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |             X              X                                             |             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +        +  +  +        +  +  +        +  +  +  +  M  M  +  M  +  +     +|             
      Leukemia Mononuclear                 |             X                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |             X              X                                             |             
                                            __________________________________________________________________________|             
   Spleen                                  | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |             X              X                                   X  X      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +        M  +  +        +  +  +        +  +  +  +  +  +  +  M  +  +     +|             
      Leukemia Mononuclear                 |             X              X                                             |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M        +  M  +        M  +  +        +  M  M  M  +  +  +  +  +  M     +|             
      Fibroadenoma                         |                            X  X        X           X        X            |             
      Fibroadenoma, Multiple               |                X                                                         |             
                                            __________________________________________________________________________|             
   Skin                                    | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
 _____________________________________________________________________________________________________________________              
                                           | 7| 1| 4| 7| 7| 7| 1| 1| 7| 6| 7| 4| 4| 7| 6| 7| 7| 7| 6| 5| 7| 7| 7| 1| 4|             
                             DAY ON TEST   | 3| 8| 6| 3| 1| 3| 8| 8| 3| 7| 3| 6| 6| 3| 6| 3| 3| 3| 8| 4| 3| 3| 3| 8| 7|             
                                           | 5| 3| 4| 4| 0| 5| 2| 3| 5| 2| 5| 4| 4| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 2| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.5%                                   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    61LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Carcinoma Adenosquamous              |                                                          X               |             
      Keratoacanthoma                      |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                              +                           |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
      Alveolar/Bronchiolar Adenoma         |                                                          X               |             
      Carcinoma Adenosquamous, Metastatic, |                                                                          |             
           Skin                            |                                                          X               |             
      Leukemia Mononuclear                 |             X              X                                   X         |             
                                            __________________________________________________________________________|             
   Nose                                    | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                         +|             
                                            __________________________________________________________________________|             
   Eye                                     |                                              +                    +      |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |             X                                                            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     M|             
      Leukemia Mononuclear                 |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |             X              X                                   X  X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 6| 7| 7| 4| 7| 1| 7| 7| 1| 6| 6| 7| 7| 4| 7| 1|              |            |
                             DAY ON TEST   | 3| 6| 3| 3| 1| 3| 3| 6| 1| 8| 3| 1| 8| 6| 1| 3| 3| 6| 3| 8|              |            |
                                           | 4| 4| 4| 1| 9| 4| 4| 4| 0| 2| 4| 3| 3| 6| 2| 4| 4| 4| 4| 2|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|              |     A      |
    0.5%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |     L      |
    61LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +     +  +  +  +  +     +     M  +     +  +  +  +     +                  |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | M     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +     +  +  +  +  +     +     +  +     +  M  +  +     +                  |  47        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +     +  +  +  +  +     +     +  +     +  +  +  M     +                  |  46        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  50        |
      Carcinoma, Metastatic, Ovary         |                                        X                                 |          1 |
      Hepatocellular Adenoma               |                                                                          |          1 |
      Leukemia Mononuclear                 |          X                                X                              |         14 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                   +                    +        +                        |   4        |
      Carcinoma, Metastatic, Ovary         |                                        X                                 |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  50        |
      Leukemia Mononuclear                 |                                                                          |          5 |
      Acinus, Adenoma                      |                                              X                           |          2 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  50        |
      Leukemia Mononuclear                 |          X                                                               |          3 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  48        |
      Leukemia Mononuclear                 |          X                                X                              |          4 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  50        |
      Leukemia Mononuclear                 |          X                                X                              |          4 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  50        |
      Leukemia Mononuclear                 |          X                                X                              |         10 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +     +  +  +  +  +     +     +  +     +  +  +  M     +                  |  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +     +  +  +  +  +     +     +  +     +  +  +  M     +                  |  49        |
      Leukemia Mononuclear                 |                                           X                              |          5 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +     +  +  +  +  +     +     +  +     +  M  +  M     +                  |  46        |
      Leukemia Mononuclear                 |                                                                          |          4 |
      Pheochromocytoma Benign              |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  20                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 6| 7| 7| 4| 7| 1| 7| 7| 1| 6| 6| 7| 7| 4| 7| 1|              |            |
                             DAY ON TEST   | 3| 6| 3| 3| 1| 3| 3| 6| 1| 8| 3| 1| 8| 6| 1| 3| 3| 6| 3| 8|              |            |
                                           | 4| 4| 4| 1| 9| 4| 4| 4| 0| 2| 4| 3| 3| 6| 2| 4| 4| 4| 4| 2|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|              |     A      |
    0.5%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |     L      |
    61LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +     +  +  +  M  +     +     +  +     +  M  +  M     +                  |  39        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +     +  +  +  +  +     +     +  +     +  +  M  +     +                  |  48        |
      Pars Distalis, Adenoma               | X     X  X     X              X  X              X     X                  |         31 |
      Pars Distalis, Adenoma, Multiple     |             X                          X                                 |          4 |
      Pars Distalis, Leukemia Mononuclear  |                                           X                              |          3 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      C-Cell, Adenoma                      |             X                             X     X                        |          7 |
      Follicular Cell, Adenoma             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +     +  +  +  +  +     +     M  +     +  +  +  +     +                  |  47        |
      Adenoma                              |                         X                                                |          5 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +     +  +  +  +  +     +     M  +     +  +  +  +     +                  |  49        |
      Carcinoma                            |                                        X                                 |          1 |
      Granulosa Cell Tumor Benign          |                                                                          |          1 |
      Leukemia Mononuclear                 |          X                                X                              |          3 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  50        |
      Polyp Stromal                        |                                              X  X                        |          7 |
      Polyp Stromal, Multiple              |       X                                                                  |          1 |
      Sarcoma Stromal                      |                X                                                         |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  49        |
      Leukemia Mononuclear                 |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  50        |
      Mediastinal, Carcinoma, Metastatic,  |                                                                          |            |
           Ovary                           |                                        X                                 |          1 |
      Mediastinal, Leukemia Mononuclear    |          X                                                               |          6 |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M     +  +  +  +  +     M     +  +     +  +  +  +     +                  |  45        |
      Leukemia Mononuclear                 |          X                                X                              |          8 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  50        |
      Leukemia Mononuclear                 |          X                                X                              |          8 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  21                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 6| 7| 7| 4| 7| 1| 7| 7| 1| 6| 6| 7| 7| 4| 7| 1|              |            |
                             DAY ON TEST   | 3| 6| 3| 3| 1| 3| 3| 6| 1| 8| 3| 1| 8| 6| 1| 3| 3| 6| 3| 8|              |            |
                                           | 4| 4| 4| 1| 9| 4| 4| 4| 0| 2| 4| 3| 3| 6| 2| 4| 4| 4| 4| 2|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|              |     A      |
    0.5%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |     L      |
    61LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  49        |
      Leukemia Mononuclear                 |          X                                X                              |         13 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +     +  +  M  +  +     +     M  +     +  M  M  +     +                  |  42        |
      Leukemia Mononuclear                 |          X                                                               |          8 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +     +  M  +  +  +     +     +  +     +  +  +  M     M                  |  37        |
      Fibroadenoma                         | X           X     X     X     X        X  X  X                           |         16 |
      Fibroadenoma, Multiple               |                X                 X                                       |          3 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  50        |
      Carcinoma Adenosquamous              |                                                                          |          1 |
      Keratoacanthoma                      |          X                                                               |          1 |
      Subcutaneous Tissue, Fibroma         |                                                                          |          3 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  50        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          1 |
      Carcinoma Adenosquamous, Metastatic, |                                                                          |            |
           Skin                            |                                                                          |          1 |
      Leukemia Mononuclear                 |          X                                X                              |         13 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +     +  +  +  +  +     +     +  +     +  +  M  +     +                  |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |             +                                                            |   3        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                           +                              |   8        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   4        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  22                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 6| 7| 7| 4| 7| 1| 7| 7| 1| 6| 6| 7| 7| 4| 7| 1|              |            |
                             DAY ON TEST   | 3| 6| 3| 3| 1| 3| 3| 6| 1| 8| 3| 1| 8| 6| 1| 3| 3| 6| 3| 8|              |            |
                                           | 4| 4| 4| 1| 9| 4| 4| 4| 0| 2| 4| 3| 3| 6| 2| 4| 4| 4| 4| 2|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|              |     A      |
    0.5%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |     L      |
    61LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |          X                                X                              |          8 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +     +  +  +  +  +     +     +  +     +  M  +  +     +                  |  48        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  50        |
      Leukemia Mononuclear                 |          X                                X                              |         15 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  23                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 4| 7| 7| 6| 5| 1| 7| 7| 7| 1| 7| 7| 7| 4| 7| 6| 1| 1| 7| 4| 5|             
                             DAY ON TEST   | 3| 1| 7| 4| 6| 3| 3| 5| 3| 8| 3| 3| 3| 8| 3| 3| 3| 6| 3| 4| 8| 8| 3| 6| 5|             
                                           | 1| 6| 2| 5| 4| 4| 4| 0| 1| 2| 4| 4| 4| 2| 4| 1| 1| 4| 1| 3| 2| 2| 1| 4| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    1.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    61HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  A  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
      Leukemia Mononuclear                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +     +  +  M  +     +  +  M     +  +  +     +  +        +     +|             
      Leukemia Mononuclear                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +     +  +  +  +     +  M  +     +  +  +     +  +        +     +|             
      Leukemia Mononuclear                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  A  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
      Leukemia Mononuclear                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
      Leukemia Mononuclear                 |                         X                                                |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
      Leukemia Mononuclear                 |          X              X                                X        X      |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +        +                                                      |             
      Leukemia Mononuclear                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +     +  +  M  +     +  +  +     +  +  +     +  +        +     +|             
      Leukemia Mononuclear                 |          X              X                                                |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
      Leukemia Mononuclear                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
      Leukemia Mononuclear                 |          X                                                               |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
      Leukemia Mononuclear                 |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
      Leukemia Mononuclear                 |          X              X                                                |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |                         X                                                |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
      Leukemia Mononuclear                 |          X              X                                                |             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  M     +  +  M  +     +  +  +     +  +  +     +  +        +     +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M     M  +  +  +     +  +  +     +  +  +     +  M        +     M|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 4| 7| 7| 6| 5| 1| 7| 7| 7| 1| 7| 7| 7| 4| 7| 6| 1| 1| 7| 4| 5|             
                             DAY ON TEST   | 3| 1| 7| 4| 6| 3| 3| 5| 3| 8| 3| 3| 3| 8| 3| 3| 3| 6| 3| 4| 8| 8| 3| 6| 5|             
                                           | 1| 6| 2| 5| 4| 4| 4| 0| 1| 2| 4| 4| 4| 2| 4| 1| 1| 4| 1| 3| 2| 2| 1| 4| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    1.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    61HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
      Pars Distalis, Adenoma               |    X           X     X           X  X        X        X  X              X|             
      Pars Distalis, Adenoma, Multiple     |                               X                                          |             
      Pars Distalis, Leukemia Mononuclear  |          X              X                                                |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
      Bilateral, C-Cell, Adenoma           |                                              X                           |             
      C-Cell, Adenoma                      |       X                 X        X                                       |             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +     +  +  M  +     M  +  M     +  +  +     +  +        +     +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                           X                              |             
      Leukemia Mononuclear                 |                         X                                                |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
      Leukemia Mononuclear                 |          X              X                                                |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
      Leukemia Mononuclear                 |          X                                                               |             
      Polyp Stromal                        | X              X  X                                   X  X               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  M        +     +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
      Axillary, Leukemia Mononuclear       |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |          X                                                               |             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +     +  +  +  M     +  +  +     +  +  +     +  +        +     +|             
      Leukemia Mononuclear                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
      Leukemia Mononuclear                 |          X              X                                         X      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
      Leukemia Mononuclear                 |          X              X                                X        X      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +     +  M  M  +     M  +  +     +  +  +     +  +        +     +|             
      Leukemia Mononuclear                 |          X              X                                                |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
      Adenoma                              |                                                       X                  |             
      Fibroadenoma                         | X     X           X  X        X     X     X                              |             
      Fibroadenoma, Multiple               |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 4| 7| 7| 6| 5| 1| 7| 7| 7| 1| 7| 7| 7| 4| 7| 6| 1| 1| 7| 4| 5|             
                             DAY ON TEST   | 3| 1| 7| 4| 6| 3| 3| 5| 3| 8| 3| 3| 3| 8| 3| 3| 3| 6| 3| 4| 8| 8| 3| 6| 5|             
                                           | 1| 6| 2| 5| 4| 4| 4| 0| 1| 2| 4| 4| 4| 2| 4| 1| 1| 4| 1| 3| 2| 2| 1| 4| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    1.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    61HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
      Leukemia Mononuclear                 |                         X                                                |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |          +                                                               |             
      Leukemia Mononuclear                 |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
      Leukemia Mononuclear                 |          X              X                                                |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                         +                                                |             
      Leukemia Mononuclear                 |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Leukemia Mononuclear                 |          X              X                                                |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +     +  +  +  +     +  +  +     +  M  +     +  +        +     +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
      Leukemia Mononuclear                 |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                 +                       +|             
      Squamous Cell Papilloma              |                                                 X                        |             
                                            __________________________________________________________________________|             
   Eye                                     | +     +  I     +     +              +     +                              |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +     +        +     +              +     +                              |             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
      Leukemia Mononuclear                 |          X              X                                                |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
      Leukemia Mononuclear                 |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
      Leukemia Mononuclear                 |          X              X                                X        X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 4| 4| 6| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 1| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 2| 6| 6| 8| 3| 3| 3| 3| 9| 3| 2| 6| 2| 1| 3| 2| 8| 2| 1|             
                                           | 1| 1| 1| 1| 2| 1| 2| 4| 4| 6| 1| 1| 1| 1| 2| 0| 9| 4| 9| 0| 0| 9| 3| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    1.0%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    61HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  M  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                   X        X                                             |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +                 +                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Squamous Cell Papilloma              |                                                                         X|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                   X        X                                             |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Adenoma                              |             X                                                            |             
      Leukemia Mononuclear                 |                            X                                             |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  M        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                            X                                             |             
      Pheochromocytoma Benign              |                                     X  X                                 |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Adenoma                              |                            X                                             |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 4| 4| 6| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 1| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 2| 6| 6| 8| 3| 3| 3| 3| 9| 3| 2| 6| 2| 1| 3| 2| 8| 2| 1|             
                                           | 1| 1| 1| 1| 2| 1| 2| 4| 4| 6| 1| 1| 1| 1| 2| 0| 9| 4| 9| 0| 0| 9| 3| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    1.0%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    61HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  M  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Pars Distalis, Adenoma               | X     X        X           X  X  X  X     X  X           X  X  X        X|             
      Pars Distalis, Adenoma, Multiple     |                                                                          |             
      Pars Distalis, Leukemia Mononuclear  |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Bilateral, C-Cell, Adenoma           |                                                                          |             
      C-Cell, Adenoma                      |                            X     X  X                                    |             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  M  +  +  +        +  +  +  M  +  +  +  +     +  +  +  +     +  M|             
      Adenoma                              |                               X                             X            |             
      Carcinoma                            |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                   X                                                      |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Polyp Stromal                        |             X                    X           X                 X         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Axillary, Leukemia Mononuclear       |                   X                                                      |             
      Mediastinal, Leukemia Mononuclear    |                   X        X                                             |             
      Pancreatic, Leukemia Mononuclear     |                   X        X                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +        +  +  +  M  +  +  +  +     +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                   X        X                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                   X        X                                             |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                   X        X                                             |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +        +  +  +  +  +  +  +  +     M  +  +  +     +  +|             
      Leukemia Mononuclear                 |                   X        X                                             |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  M  +  +        +  +  +  +  +  +  +  M     +  +  +  +     +  +|             
      Adenoma                              |                                                                          |             
      Fibroadenoma                         | X        X     X                       X              X     X  X         |             
      Fibroadenoma, Multiple               |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 4| 4| 6| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 1| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 2| 6| 6| 8| 3| 3| 3| 3| 9| 3| 2| 6| 2| 1| 3| 2| 8| 2| 1|             
                                           | 1| 1| 1| 1| 2| 1| 2| 4| 4| 6| 1| 1| 1| 1| 2| 0| 9| 4| 9| 0| 0| 9| 3| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    1.0%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    61HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Subcutaneous Tissue, Fibroma         |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                          +               |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                         X|             
      Leukemia Mononuclear                 |                   X        X                                             |             
                                            __________________________________________________________________________|             
   Nose                                    | +  M  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                           +                              |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |          +                                      +        +           +  +|             
                                            __________________________________________________________________________|             
   Harderian Gland                         |          +                                      +        +           +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                           +                              |             
      Carcinoma                            |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                            X                                             |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                   X        X                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 7| 7| 7| 7| 7| 1| 7| 6| 4| 7| 4| 4| 1| 7| 4| 1| 1| 6| 4|              |            |
                             DAY ON TEST   | 8| 2| 2| 2| 2| 2| 8| 2| 3| 9| 2| 6| 6| 8| 2| 6| 8| 8| 5| 6|              |            |
                                           | 2| 9| 9| 9| 9| 9| 2| 9| 2| 7| 9| 4| 4| 2| 9| 4| 3| 2| 1| 4|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|              |     A      |
    1.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |     L      |
    61HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +  +  +  +  +     +  +  +  +           +           +                  |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +  +  +  +  +     +  +  +  +           +           +                  |  47        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +  +  +  +  +     +  +  +  +           +           +                  |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +  +  +  +  +     +  +  +  +           +           +                  |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +  +  +  +  +     +  +  +  +           +           +                  |  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
      Leukemia Mononuclear                 |          X           X     X  X                                          |         10 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +           +                                                         |   6        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +  +  +  +  +     +  +  +  +           +           +                  |  49        |
      Leukemia Mononuclear                 |          X                                                               |          3 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
      Leukemia Mononuclear                 |          X           X     X                                             |          7 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
      Adenoma                              |                                                                          |          1 |
      Leukemia Mononuclear                 |                      X     X                                             |          4 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    +  +  +  +  +     +  +  +  +           +           +                  |  49        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  30                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 7| 7| 7| 7| 7| 1| 7| 6| 4| 7| 4| 4| 1| 7| 4| 1| 1| 6| 4|              |            |
                             DAY ON TEST   | 8| 2| 2| 2| 2| 2| 8| 2| 3| 9| 2| 6| 6| 8| 2| 6| 8| 8| 5| 6|              |            |
                                           | 2| 9| 9| 9| 9| 9| 2| 9| 2| 7| 9| 4| 4| 2| 9| 4| 3| 2| 1| 4|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|              |     A      |
    1.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |     L      |
    61HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |                      X     X                                             |          5 |
      Pheochromocytoma Benign              |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +  +  +  +  +     +  +  +  +           +           +                  |  48        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    M  +  +  +  +     +  +  +  +           +           +                  |  45        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +  +  +  +  +     +  +  +  +           +           +                  |  49        |
      Pars Distalis, Adenoma               |       X     X  X     X  X     X                       X                  |         29 |
      Pars Distalis, Adenoma, Multiple     |                                                                          |          1 |
      Pars Distalis, Leukemia Mononuclear  |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
      Bilateral, C-Cell, Adenoma           |                                                                          |          1 |
      C-Cell, Adenoma                      |    X                                                                     |          7 |
      Follicular Cell, Adenoma             |                      X                                                   |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |    +  +  +  +  +     +  +  +  +           +           +                  |  44        |
      Adenoma                              |                                                                          |          2 |
      Carcinoma                            |             X                                                            |          2 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Ovary                                   |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
      Leukemia Mononuclear                 |          X                 X                                             |          5 |
                                            __________________________________________________________________________|____________|
   Uterus                                  |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Polyp Stromal                        |    X                    X     X                                          |         12 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +  +  +  +  +     +  +  +  +           +           +                  |  49        |
      Leukemia Mononuclear                 |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
      Axillary, Leukemia Mononuclear       |                                                                          |          1 |
      Mediastinal, Leukemia Mononuclear    |                      X                                                   |          4 |
      Pancreatic, Leukemia Mononuclear     |                      X                                                   |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |    +  +  +  +  +     +  +  +  +           +           +                  |  48        |
      Leukemia Mononuclear                 |          X           X                                                   |          5 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +  +  +  +  +     +  M  +  +           +           +                  |  49        |
      Leukemia Mononuclear                 |          X           X     X                                             |          8 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  31                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 7| 7| 7| 7| 7| 1| 7| 6| 4| 7| 4| 4| 1| 7| 4| 1| 1| 6| 4|              |            |
                             DAY ON TEST   | 8| 2| 2| 2| 2| 2| 8| 2| 3| 9| 2| 6| 6| 8| 2| 6| 8| 8| 5| 6|              |            |
                                           | 2| 9| 9| 9| 9| 9| 2| 9| 2| 7| 9| 4| 4| 2| 9| 4| 3| 2| 1| 4|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|              |     A      |
    1.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |     L      |
    61HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
      Leukemia Mononuclear                 |          X           X     X  X                                          |         10 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |    M  +  +  +  +     +  M  +  +           +           +                  |  43        |
      Leukemia Mononuclear                 |          X           X                                                   |          6 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +  +  +  M  +     +  +  +  +           +           +                  |  47        |
      Adenoma                              |                                           X                              |          2 |
      Fibroadenoma                         |                X              X                                          |         16 |
      Fibroadenoma, Multiple               |                                                                          |          2 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    |    +  +  +  M  +     +  +  +  +           +           +                  |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   2        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
      Alveolar/Bronchiolar Adenoma         |                               X                                          |          2 |
      Leukemia Mononuclear                 |          X           X     X  X                                          |          8 |
                                            __________________________________________________________________________|____________|
   Nose                                    |    +  +  +  +  +     +  +  +  +           +           +                  |  48        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   3        |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Eye                                     |          +  +  +        +                 +           +                  |  17        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |          +  +                             +           +                  |  15        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  32                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 7| 7| 7| 7| 7| 1| 7| 6| 4| 7| 4| 4| 1| 7| 4| 1| 1| 6| 4|              |            |
                             DAY ON TEST   | 8| 2| 2| 2| 2| 2| 8| 2| 3| 9| 2| 6| 6| 8| 2| 6| 8| 8| 5| 6|              |            |
                                           | 2| 9| 9| 9| 9| 9| 2| 9| 2| 7| 9| 4| 4| 2| 9| 4| 3| 2| 1| 4|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|              |     A      |
    1.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |     L      |
    61HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Adenoma                              |                                           X                              |          1 |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
      Carcinoma                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
      Leukemia Mononuclear                 |                      X                                                   |          4 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
      Leukemia Mononuclear                 |          X           X     X  X                                          |         10 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  33                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 1| 7| 7| 6| 6| 5| 7| 7| 6| 4| 6| 1| 1| 7| 7| 1| 5| 7| 6| 6| 4|             
                             DAY ON TEST   | 3| 3| 3| 7| 7| 3| 0| 7| 3| 9| 3| 2| 6| 7| 5| 7| 7| 3| 3| 7| 8| 1| 8| 6| 7|             
                                           | 1| 1| 2| 0| 5| 2| 7| 3| 7| 8| 1| 4| 5| 0| 5| 5| 5| 1| 1| 5| 7| 0| 9| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    D 61 UM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +        +  +  +  +  +  +  +  +     +        +  +     M  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +        +  +  +  +  +  +  +  A     +        +  +     A  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +        +  +  +  +  +  +  +  A     +        +  +     A  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +        +  +  +  +  +  +  +  A     +        +  +     A  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +        +  +  +  +  +  +  +  A     +        +  +     A  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +        +  +  +  +  +  +  +  A     +        +  +     A  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +        +  +  +  +  +  +  +  A     +        +  +     A  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +        +  +  +  +  +  +  +  A     +        +  +     A  +  +  +   |             
      Leukemia Mononuclear                 |                         X                                                |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +        +  +  +  +  +  +  +  A     +        +  +     A  +  +  +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
      Fibrosarcoma, Metastatic, Skin       |                                                                          |             
      Hepatocellular Adenoma               |                                                                          |             
      Leukemia Mononuclear                 |                   X  X  X  X              X                 X     X  X   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +                                                   |             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
      Leukemia Mononuclear                 |                            X                                             |             
      Mesothelioma Malignant               |                                                                          |             
      Acinus, Adenoma                      |                                                                          |             
      Acinus, Adenoma, Multiple            |                X                                                         |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
      Palate, Squamous Cell Papilloma      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
      Leukemia Mononuclear                 |                                                             X            |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +        +  +  +  +  +  +  +  A     +        +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
      Leukemia Mononuclear                 |                   X        X                                X        X   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
      Carcinoma                            |                                                                          |             
      Leukemia Mononuclear                 |                   X        X                                X     X      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
      Leukemia Mononuclear                 |                   X     X  X                                X     X      |             
      Pheochromocytoma Malignant           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 1| 7| 7| 6| 6| 5| 7| 7| 6| 4| 6| 1| 1| 7| 7| 1| 5| 7| 6| 6| 4|             
                             DAY ON TEST   | 3| 3| 3| 7| 7| 3| 0| 7| 3| 9| 3| 2| 6| 7| 5| 7| 7| 3| 3| 7| 8| 1| 8| 6| 7|             
                                           | 1| 1| 2| 0| 5| 2| 7| 3| 7| 8| 1| 4| 5| 0| 5| 5| 5| 1| 1| 5| 7| 0| 9| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    D 61 UM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pheochromocytoma Benign              |                X     X                    X                    X         |             
      Bilateral, Pheochromocytoma Benign   |    X  X           X              X                    X                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +        +  +  +  +  +  +  +  +     +        +  +     A  +  +  +   |             
      Adenoma                              |                                                    X                     |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                   X      |             
      Pars Distalis, Adenoma               |    X  X                 X  X  X     X              X           X         |             
      Pars Distalis, Leukemia Mononuclear  |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +        +  +  +  +  +  +  +  A     +        +  +     +  +  +  +   |             
      Leukemia Mononuclear                 |                                                             X            |             
      C-Cell, Adenoma                      |                                                                          |             
      C-Cell, Adenoma, Multiple            |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +        +  +  +  +  +  +  +  M     +        +  +     +  +  +  +   |             
      Mesothelioma Malignant               |    X                                                                     |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +        +  +  +  +  +  +  +  M     +        +  +     +  +  +  +   |             
      Adenoma                              |       X                          X                                       |             
      Carcinoma                            |                                                                          |             
      Bilateral, Adenoma                   |                                                       X                  |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +        +  +  +  +  +  +  +  M     +        +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +        +  +  +  +  +  +  +  M     +        +  +     +  +  +  +   |             
      Leukemia Mononuclear                 |                                                             X            |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
      Leukemia Mononuclear                 |                                                             X            |             
      Bilateral, Interstitial Cell, Adenoma| X  X  X        X     X        X           X           X     X  X  X  X   |             
      Interstitial Cell, Adenoma           |                   X     X  X     X  X              X                     |             
      Tunic, Mesothelioma Malignant        |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                            +                                             |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +        +  +  +  +  +  +  +  +     +        +  +     A  +  +  +   |             
      Leukemia Mononuclear                 |                                                                   X      |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
      Lumbar, Leukemia Mononuclear         |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |                         X                                         X  X   |             
      Pancreatic, Leukemia Mononuclear     |                                                                      X   |             
      Renal, Leukemia Mononuclear          |                                                                   X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +        +  +  +  +  +  +  +  M     +        +  +     +  M  +  +   |             
      Leukemia Mononuclear                 |                            X                                X     X  X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 1| 7| 7| 6| 6| 5| 7| 7| 6| 4| 6| 1| 1| 7| 7| 1| 5| 7| 6| 6| 4|             
                             DAY ON TEST   | 3| 3| 3| 7| 7| 3| 0| 7| 3| 9| 3| 2| 6| 7| 5| 7| 7| 3| 3| 7| 8| 1| 8| 6| 7|             
                                           | 1| 1| 2| 0| 5| 2| 7| 3| 7| 8| 1| 4| 5| 0| 5| 5| 5| 1| 1| 5| 7| 0| 9| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    D 61 UM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
      Leukemia Mononuclear                 |                            X                                X     X  X   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
      Leukemia Mononuclear                 |                   X  X  X  X              X                 X     X  X   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
      Leukemia Mononuclear                 |                   X        X                                X     X  X   |             
      Thymoma Benign                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  M        +  M  +  +  M  +  M  +     +        +  +     M  +  M  +   |             
      Adenoma                              |                                                                X         |             
      Fibroadenoma                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
      Basal Cell Carcinoma                 |                                  X                                       |             
      Leukemia Mononuclear                 |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
      Leukemia Mononuclear                 |                            X                                X     X      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Carcinoma, Metastatic, Adrenal Gland |                                                                          |             
      Carcinoma, Metastatic, Preputial     |                                                                          |             
          Gland                            |                                                                          |             
      Leukemia Mononuclear                 |                   X  X  X  X              X                       X  X   |             
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |             
          Primary Site                     |                            X                                             |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
      Leukemia Mononuclear                 |                                                             X            |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                         +                                                |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                   +     +                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 1| 7| 7| 6| 6| 5| 7| 7| 6| 4| 6| 1| 1| 7| 7| 1| 5| 7| 6| 6| 4|             
                             DAY ON TEST   | 3| 3| 3| 7| 7| 3| 0| 7| 3| 9| 3| 2| 6| 7| 5| 7| 7| 3| 3| 7| 8| 1| 8| 6| 7|             
                                           | 1| 1| 2| 0| 5| 2| 7| 3| 7| 8| 1| 4| 5| 0| 5| 5| 5| 1| 1| 5| 7| 0| 9| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    D 61 UM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
      Leukemia Mononuclear                 |                   X  X  X  X                                X     X  X   |             
      Renal Tubule, Adenoma                |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +        +  +  +  +  +  +  +  M     +        +  +     +  +  +  +   |             
      Leukemia Mononuclear                 |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
      Leukemia Mononuclear                 |                   X  X  X  X              X                 X     X  X   |             
      Mesothelioma Malignant               |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 1| 6| 1| 6| 4| 6| 6| 2| 7| 7| 7| 4| 7| 4| 7| 6| 1| 6| 7| 4| 4| 4| 1|             
                             DAY ON TEST   | 3| 2| 7| 1| 7| 5| 7| 3| 2| 8| 3| 3| 3| 7| 2| 7| 1| 5| 7| 1| 1| 7| 7| 7| 7|             
                                           | 1| 5| 5| 0| 6| 8| 0| 7| 5| 8| 1| 2| 2| 0| 1| 0| 0| 1| 6| 9| 3| 0| 0| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATE                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    D 61 UM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +     +     +     +  +  +  +  +  +     +     +  +     +  A            |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +     +     +     +  +  +  +  +  +     +     +  +     +  A            |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +     +     +     +  +  +  +  +  +     +     +  +     +  A            |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +     +     +     +  +  +  +  +  +     +     +  +     +  A            |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +     +     M     +  +  +  +  +  +     +     +  +     +  A            |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +     +     M     +  +  +  +  +  +     +     +  +     +  A            |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
      Fibrosarcoma, Metastatic, Skin       |                                                                          |             
      Hepatocellular Adenoma               |                                     X                                    |             
      Leukemia Mononuclear                 | X  X     X                                X     X  X                     |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                    +                     |             
      Leukemia Mononuclear                 |                                                    X                     |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
      Leukemia Mononuclear                 |          X                                                               |             
      Mesothelioma Malignant               |                                                                          |             
      Acinus, Adenoma                      |                                                                          |             
      Acinus, Adenoma, Multiple            |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                         +                                                |             
      Palate, Squamous Cell Papilloma      |                         X                                                |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +     +     +     +  +  +  +  +  +     +     +  +     M  +            |             
      Leukemia Mononuclear                 |                                                 X                        |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
      Squamous Cell Papilloma              |          X                                                               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
      Leukemia Mononuclear                 |    X     X                                X     X  X                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
      Carcinoma                            |                                                             X            |             
      Leukemia Mononuclear                 |    X     X                                X     X  X                     |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
      Leukemia Mononuclear                 |    X     X                                X     X  X                     |             
      Pheochromocytoma Malignant           | X                    X                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 1| 6| 1| 6| 4| 6| 6| 2| 7| 7| 7| 4| 7| 4| 7| 6| 1| 6| 7| 4| 4| 4| 1|             
                             DAY ON TEST   | 3| 2| 7| 1| 7| 5| 7| 3| 2| 8| 3| 3| 3| 7| 2| 7| 1| 5| 7| 1| 1| 7| 7| 7| 7|             
                                           | 1| 5| 5| 0| 6| 8| 0| 7| 5| 8| 1| 2| 2| 0| 1| 0| 0| 1| 6| 9| 3| 0| 0| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATE                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    D 61 UM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pheochromocytoma Benign              | X                    X                          X  X        X            |             
      Bilateral, Pheochromocytoma Benign   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +     +     M     M  +  +  M  +  +     +     +  +     +  +            |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +     +     +     M  +  +  +  +  +     +     +  +     +  +            |             
      Leukemia Mononuclear                 |                                                 X  X                     |             
      Pars Distalis, Adenoma               | X        X                    X                 X                        |             
      Pars Distalis, Leukemia Mononuclear  |          X                                                               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
      Leukemia Mononuclear                 |                                                                          |             
      C-Cell, Adenoma                      |                      X              X                                    |             
      C-Cell, Adenoma, Multiple            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
      Adenoma                              |                               X  X                                       |             
      Carcinoma                            |                                                                          |             
      Bilateral, Adenoma                   |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +     +     +     +  M  +  +  +  +     +     +  +     +  +            |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +     +     +     +  M  +  +  +  +     +     +  +     +  +            |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
      Leukemia Mononuclear                 |                                                                          |             
      Bilateral, Interstitial Cell, Adenoma| X  X     X     X     X  X     X  X  X     X     X           X            |             
      Interstitial Cell, Adenoma           |                                                    X     X               |             
      Tunic, Mesothelioma Malignant        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
      Lumbar, Leukemia Mononuclear         |                                                    X                     |             
      Mediastinal, Leukemia Mononuclear    |    X     X                                X     X  X                     |             
      Pancreatic, Leukemia Mononuclear     |                                                 X  X                     |             
      Renal, Leukemia Mononuclear          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +     +     +     +  +  +  +  +  +     +     +  +     M  +            |             
      Leukemia Mononuclear                 |    X     X                                X     X  X                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 1| 6| 1| 6| 4| 6| 6| 2| 7| 7| 7| 4| 7| 4| 7| 6| 1| 6| 7| 4| 4| 4| 1|             
                             DAY ON TEST   | 3| 2| 7| 1| 7| 5| 7| 3| 2| 8| 3| 3| 3| 7| 2| 7| 1| 5| 7| 1| 1| 7| 7| 7| 7|             
                                           | 1| 5| 5| 0| 6| 8| 0| 7| 5| 8| 1| 2| 2| 0| 1| 0| 0| 1| 6| 9| 3| 0| 0| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATE                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    D 61 UM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +     +     M     +  +  +  +  +  +     +     +  +     +  +            |             
      Leukemia Mononuclear                 |    X                                      X     X  X                     |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
      Leukemia Mononuclear                 | X  X     X                                X     X  X                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +     +     M     M  M  +  +  +  +     +     +  +     +  +            |             
      Leukemia Mononuclear                 |    X                                      X     X  X                     |             
      Thymoma Benign                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +     +     M     +  +  +  +  M  M     +     M  +     M  M            |             
      Adenoma                              |                                                                          |             
      Fibroadenoma                         |    X                          X                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +     +     +     +  +  +  +  +  +     +     +  +     +  M            |             
      Basal Cell Carcinoma                 |                                                                          |             
      Leukemia Mononuclear                 |          X                                                               |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
      Leukemia Mononuclear                 |          X                                         X                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Carcinoma, Metastatic, Adrenal Gland |                                                             X            |             
      Carcinoma, Metastatic, Preputial     |                                                                          |             
          Gland                            |                                                                          |             
      Leukemia Mononuclear                 |    X     X                                X     X  X                     |             
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |             
          Primary Site                     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +     +     +     M  +  +  +  +  +     +     +  +     +  +            |             
      Leukemia Mononuclear                 |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                 +  +                     |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                 +  +                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 1| 6| 1| 6| 4| 6| 6| 2| 7| 7| 7| 4| 7| 4| 7| 6| 1| 6| 7| 4| 4| 4| 1|             
                             DAY ON TEST   | 3| 2| 7| 1| 7| 5| 7| 3| 2| 8| 3| 3| 3| 7| 2| 7| 1| 5| 7| 1| 1| 7| 7| 7| 7|             
                                           | 1| 5| 5| 0| 6| 8| 0| 7| 5| 8| 1| 2| 2| 0| 1| 0| 0| 1| 6| 9| 3| 0| 0| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATE                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    D 61 UM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                    +                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
      Leukemia Mononuclear                 |    X     X                                      X  X                     |             
      Renal Tubule, Adenoma                |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
      Leukemia Mononuclear                 | X  X     X                                X     X  X                     |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 4| 7| 7| 6| 6| 1| 7| 7| 7| 7| 7| 1| 4| 7| 6| 5|              |            |
                             DAY ON TEST   | 3| 3| 3| 6| 8| 3| 3| 9| 0| 7| 3| 3| 3| 3| 3| 7| 7| 2| 3| 0|              |            |
                                           | 1| 1| 2| 6| 5| 1| 2| 4| 5| 6| 1| 1| 1| 2| 2| 5| 0| 2| 9| 8|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     A      |
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |     L      |
    D 61 UM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  M  +  +  +  +     +  +  +  +  +        +  +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +     +  +  M  +  +        +  +  +               |  45        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  46        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  50        |
      Fibrosarcoma, Metastatic, Skin       |                               X                                          |          1 |
      Hepatocellular Adenoma               |                                                                          |          1 |
      Leukemia Mononuclear                 |             X        X  X           X              X                     |         19 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +                                                               |   3        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Mesothelioma Malignant               |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  50        |
      Leukemia Mononuclear                 |                         X                                                |          3 |
      Mesothelioma Malignant               |          X                                                               |          1 |
      Acinus, Adenoma                      |                                                    X                     |          1 |
      Acinus, Adenoma, Multiple            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
      Palate, Squamous Cell Papilloma      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  49        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  50        |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  49        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                         +                                                |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  50        |
      Leukemia Mononuclear                 |             X        X  X                                                |         12 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  42                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 4| 7| 7| 6| 6| 1| 7| 7| 7| 7| 7| 1| 4| 7| 6| 5|              |            |
                             DAY ON TEST   | 3| 3| 3| 6| 8| 3| 3| 9| 0| 7| 3| 3| 3| 3| 3| 7| 7| 2| 3| 0|              |            |
                                           | 1| 1| 2| 6| 5| 1| 2| 4| 5| 6| 1| 1| 1| 2| 2| 5| 0| 2| 9| 8|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     A      |
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |     L      |
    D 61 UM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Carcinoma                            |                                                                          |          1 |
      Leukemia Mononuclear                 |             X        X  X                          X                     |         13 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  50        |
      Leukemia Mononuclear                 |             X        X                             X                     |         13 |
      Pheochromocytoma Malignant           |                                                                          |          2 |
      Pheochromocytoma Benign              |    X  X                          X                    X                  |         13 |
      Bilateral, Pheochromocytoma Benign   |                                     X                                    |          6 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +     +  M  +  +  +        +  +  +               |  48        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  47        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | M  +  +  +  M  +  +  +  +     +  +  +  +  +        M  +  M               |  45        |
      Leukemia Mononuclear                 |                      X                                                   |          4 |
      Pars Distalis, Adenoma               |    X           X              X        X              X                  |         17 |
      Pars Distalis, Leukemia Mononuclear  |                         X                                                |          2 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      C-Cell, Adenoma                      |                X  X           X  X                                       |          6 |
      C-Cell, Adenoma, Multiple            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  49        |
      Mesothelioma Malignant               |          X                                                               |          2 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +        M  +  +               |  48        |
      Adenoma                              | X                 X                    X              X                  |          8 |
      Carcinoma                            |                                                          X               |          1 |
      Bilateral, Adenoma                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  48        |
      Leukemia Mononuclear                 |                      X                                                   |          2 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Bilateral, Interstitial Cell, Adenoma| X  X  X  X     X  X  X        X  X  X     X        X     X               |         37 |
      Interstitial Cell, Adenoma           |                         X              X                                 |         10 |
      Tunic, Mesothelioma Malignant        |          X                                                               |          2 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  43                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 4| 7| 7| 6| 6| 1| 7| 7| 7| 7| 7| 1| 4| 7| 6| 5|              |            |
                             DAY ON TEST   | 3| 3| 3| 6| 8| 3| 3| 9| 0| 7| 3| 3| 3| 3| 3| 7| 7| 2| 3| 0|              |            |
                                           | 1| 1| 2| 6| 5| 1| 2| 4| 5| 6| 1| 1| 1| 2| 2| 5| 0| 2| 9| 8|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     A      |
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |     L      |
    D 61 UM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  49        |
      Leukemia Mononuclear                 |                         X                                                |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  50        |
      Lumbar, Leukemia Mononuclear         |                                                                          |          1 |
      Mediastinal, Leukemia Mononuclear    |             X                                                            |          9 |
      Pancreatic, Leukemia Mononuclear     |             X                                                            |          4 |
      Renal, Leukemia Mononuclear          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  M  +               |  46        |
      Leukemia Mononuclear                 |             X           X                                                |         11 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  49        |
      Leukemia Mononuclear                 |             X           X                                                |         10 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  50        |
      Leukemia Mononuclear                 |             X        X  X           X              X                     |         19 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  M  +  M  +  M  +  +     +  +  M  M  +        +  +  +               |  41        |
      Leukemia Mononuclear                 |                      X                                                   |         10 |
      Thymoma Benign                       |                                           X                              |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  M  M  +  +  M  M  +  +     +  M  +  M  M        +  M  M               |  28        |
      Adenoma                              |                                                                          |          1 |
      Fibroadenoma                         |                                     X                                    |          3 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  M               |  48        |
      Basal Cell Carcinoma                 |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |                               X                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |          +                                                               |   1        |
      Mesothelioma Malignant               |          X                                                               |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  50        |
      Leukemia Mononuclear                 |             X                                                            |          6 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  50        |
      Alveolar/Bronchiolar Adenoma         |          X        X                                                      |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  44                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 4| 7| 7| 6| 6| 1| 7| 7| 7| 7| 7| 1| 4| 7| 6| 5|              |            |
                             DAY ON TEST   | 3| 3| 3| 6| 8| 3| 3| 9| 0| 7| 3| 3| 3| 3| 3| 7| 7| 2| 3| 0|              |            |
                                           | 1| 1| 2| 6| 5| 1| 2| 4| 5| 6| 1| 1| 1| 2| 2| 5| 0| 2| 9| 8|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     A      |
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |     L      |
    D 61 UM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Carcinoma, Metastatic, Adrenal Gland |                                                                          |          1 |
      Carcinoma, Metastatic, Preputial     |                                                                          |            |
          Gland                            |                                                          X               |          1 |
      Leukemia Mononuclear                 |             X        X  X                                                |         15 |
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |            |
          Primary Site                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | M  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  M               |  47        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Squamous Cell Papilloma              |                                     X                                    |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |    +  +     +                                                            |   6        |
      Squamous Cell Papilloma              |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Eye                                     |    +                                               +                     |   6        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  50        |
      Leukemia Mononuclear                 |             X           X                                                |         13 |
      Renal Tubule, Adenoma                |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  M  +  +  +  +     +  +  +  +  +        +  +  +               |  48        |
      Leukemia Mononuclear                 |                      X                                                   |          2 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  50        |
      Leukemia Mononuclear                 |             X        X  X           X              X                     |         19 |
      Mesothelioma Malignant               |          X                                                               |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  45                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
 _____________________________________________________________________________________________________________________              
                                           | 1| 1| 7| 6| 6| 7| 7| 4| 1| 6| 7| 7| 6| 1| 3| 7| 7| 6| 5| 4| 1| 7| 6| 6| 6|             
                             DAY ON TEST   | 7| 7| 3| 2| 1| 3| 1| 7| 7| 7| 3| 3| 2| 7| 9| 2| 3| 2| 8| 8| 7| 3| 5| 4| 2|             
                                           | 6| 6| 0| 0| 9| 0| 8| 0| 6| 2| 0| 0| 6| 6| 6| 8| 0| 6| 8| 1| 5| 0| 8| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.25%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
     61LM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |       +  +  +  M  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                       X                  |             
                                            __________________________________________________________________________|             
   Intestine Large                         |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  A|             
      Leukemia Mononuclear                 |                                                    X                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |       +  +  +  +  +        +  +  M  +     +  +  M  +  +  +     +  +  +  A|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                       X                  |             
      Polyp Adenomatous                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small                         |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  A|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                       X                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  A|             
      Leukemia Mononuclear                 |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  A|             
      Leukemia Mononuclear                 |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |          X        X                 X           X  X                 X  X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                       X                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                     +                 +  +               |             
      Leukemia Mononuclear                 |                                     X                                    |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                       X                  |             
                                            __________________________________________________________________________|             
   Pancreas                                |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  A|             
      Leukemia Mononuclear                 |                                     X              X                     |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                       X                  |             
      Acinus, Adenoma                      |       X                                                                  |             
      Acinus, Adenoma, Multiple            |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                    X                    X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                       X                  |             
      Sarcoma                              |       X                                                                  |             
                                            __________________________________________________________________________|             
   Stomach                                 |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |       +  +     +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
 _____________________________________________________________________________________________________________________              
                                           | 1| 1| 7| 6| 6| 7| 7| 4| 1| 6| 7| 7| 6| 1| 3| 7| 7| 6| 5| 4| 1| 7| 6| 6| 6|             
                             DAY ON TEST   | 7| 7| 3| 2| 1| 3| 1| 7| 7| 7| 3| 3| 2| 7| 9| 2| 3| 2| 8| 8| 7| 3| 5| 4| 2|             
                                           | 6| 6| 0| 0| 9| 0| 8| 0| 6| 2| 0| 0| 6| 6| 6| 8| 0| 6| 8| 1| 5| 0| 8| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.25%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
     61LM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |                                     X              X                    X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                       X                  |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |       +  +     +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                     X              X                    X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |          X                          X              X                 X  X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |          X                                         X                 X  X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                       X                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |       +  +  +  +  +        +  +  +  +     +  +  +  M  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |          X                          X                                X  X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                       X                  |             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              |                   X                                               X      |             
      Bilateral, Pheochromocytoma Benign   |       X                       X              X                 X         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  A|             
      Adenoma                              |                               X  X                                       |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |       +  +  +  M  +        +  +  +  +     +  +  +  M  +  M     +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               |       X        X  X        X  X     X                             X      |             
      Pars Distalis, Adenoma, Multiple     |                                                                          |             
      Pars Distalis, Leukemia Mononuclear  |          X                          X              X                     |             
      Pars Distalis, Lymphoma Malignant    |                                                                          |             
          Undifferentiated Cell Type       |                                                       X                  |             
      Pars Intermedia, Lymphoma Malignant  |                                                                          |             
          Undifferentiated Cell Type       |                                                       X                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                         X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
 _____________________________________________________________________________________________________________________              
                                           | 1| 1| 7| 6| 6| 7| 7| 4| 1| 6| 7| 7| 6| 1| 3| 7| 7| 6| 5| 4| 1| 7| 6| 6| 6|             
                             DAY ON TEST   | 7| 7| 3| 2| 1| 3| 1| 7| 7| 7| 3| 3| 2| 7| 9| 2| 3| 2| 8| 8| 7| 3| 5| 4| 2|             
                                           | 6| 6| 0| 0| 9| 0| 8| 0| 6| 2| 0| 0| 6| 6| 6| 8| 0| 6| 8| 1| 5| 0| 8| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.25%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
     61LM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      C-Cell, Adenoma                      |       X                    X                          X                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                                     X                                    |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
      Adenoma                              |                X                 X           X     X     X        X      |             
      Leukemia Mononuclear                 |                                                    X                    X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                       X                  |             
                                            __________________________________________________________________________|             
   Prostate                                |       +  +  +  +  +        +  +  M  +     +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                    X                     |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                       X                  |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                    X                    X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                       X                  |             
                                            __________________________________________________________________________|             
   Testes                                  |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                    X                     |             
      Bilateral, Interstitial Cell, Adenoma|       X     X  X  X        X  X  X  X           X  X           X  X  X  X|             
      Interstitial Cell, Adenoma           |          X                                                               |             
      Tunic, Mesothelioma Malignant        |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                    X                    X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                       X                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
      Axillary, Lymphoma Malignant         |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |          X        X                                X                 X  X|             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Undifferentiated Cell Type       |                                                       X                  |             
      Pancreatic, Leukemia Mononuclear     |                                     X                                   X|             
      Renal, Lymphoma Malignant            |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
 _____________________________________________________________________________________________________________________              
                                           | 1| 1| 7| 6| 6| 7| 7| 4| 1| 6| 7| 7| 6| 1| 3| 7| 7| 6| 5| 4| 1| 7| 6| 6| 6|             
                             DAY ON TEST   | 7| 7| 3| 2| 1| 3| 1| 7| 7| 7| 3| 3| 2| 7| 9| 2| 3| 2| 8| 8| 7| 3| 5| 4| 2|             
                                           | 6| 6| 0| 0| 9| 0| 8| 0| 6| 2| 0| 0| 6| 6| 6| 8| 0| 6| 8| 1| 5| 0| 8| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.25%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
     61LM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |       +  +  +  +  +        +  +  +  +     +  M  +  +  +  +     +  +  M  +|             
      Leukemia Mononuclear                 |          X        X                 X              X                    X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                       X                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |          X        X                 X              X                 X  X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                       X                  |             
                                            __________________________________________________________________________|             
   Spleen                                  |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |          X        X                 X           X  X                 X  X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                       X                  |             
      Sarcoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |       +  +  +  M  +        +  M  +  +     +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |          X        X                 X              X                 X  X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       +  +  M  M  M        M  M  M  +     +  +  M  M  +  +     M  M  M  +|             
      Fibroadenoma                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
      Keratoacanthoma                      |                                                                          |             
      Leukemia Mononuclear                 |                                                    X                     |             
      Squamous Cell Papilloma              |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                            X                                             |             
      Subcutaneous Tissue, Lipoma          |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
      Osteosarcoma                         |             X                                                            |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                    +                    +|             
      Leukemia Mononuclear                 |                                                    X                    X|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                    X                     |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Leukemia Mononuclear                 |          X        X                 X              X                 X  X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
 _____________________________________________________________________________________________________________________              
                                           | 1| 1| 7| 6| 6| 7| 7| 4| 1| 6| 7| 7| 6| 1| 3| 7| 7| 6| 5| 4| 1| 7| 6| 6| 6|             
                             DAY ON TEST   | 7| 7| 3| 2| 1| 3| 1| 7| 7| 7| 3| 3| 2| 7| 9| 2| 3| 2| 8| 8| 7| 3| 5| 4| 2|             
                                           | 6| 6| 0| 0| 9| 0| 8| 0| 6| 2| 0| 0| 6| 6| 6| 8| 0| 6| 8| 1| 5| 0| 8| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.25%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
     61LM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                       X                  |             
      Osteosarcoma, Metastatic, Bone       |             X                                                            |             
      Pheochromocytoma Malignant,          |                                                                          |             
          Metastatic, Adrenal Gland        |                                                                          |             
      Mediastinum, Sarcoma, Metastatic,    |                                                                          |             
           Salivary Glands                 |       X                                                                  |             
                                            __________________________________________________________________________|             
   Nose                                    |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                     X              X                    X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                       X                  |             
                                            __________________________________________________________________________|             
   Trachea                                 |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                           +                              |             
      Squamous Cell Carcinoma              |                                           X                              |             
                                            __________________________________________________________________________|             
   Eye                                     |          +                                                               |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |          X                          X              X                 X  X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                       X                  |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |       +  +  +  +  +        +  +  M  +     +  +  +  +  +  +     +  +  +  A|             
      Leukemia Mononuclear                 |          X                                                               |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |          X        X                 X           X  X                 X  X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                       X                  |             
      Mesothelioma Malignant               |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 6| 7| 1| 7| 6| 1| 7| 1| 7| 4| 1| 4| 7| 4| 4| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 7| 2| 6| 3| 7| 3| 5| 7| 3| 7| 3| 6| 7| 7| 3| 7| 7| 3| 7| 3| 3| 3| 2|             
                                           | 0| 0| 0| 8| 8| 0| 6| 0| 3| 6| 0| 5| 0| 7| 5| 0| 0| 0| 0| 0| 0| 0| 0| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.25%                                  | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
     61LM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +     +  +  +     +  +     +     +  A        +        +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +     +  +  +     +  +     +     +  A        +        +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +     +  +  +     +  +     +     +  A        +        +     +  +  M  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
      Polyp Adenomatous                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +     +  +  +     +  +     +     +  A        +        +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +     +  +  +     +  +     +     +  A        +        +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +     +  +  +     +  +     +     +  A        +        +     +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +     +  +  +     +  +     +     +  A        +        +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +     +  +  +     +  +     +     +  A        +        +     +  +  M  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
      Leukemia Mononuclear                 | X        X     X        X           X  X                 X     X     X  X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +                          +                                 |             
      Leukemia Mononuclear                 |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +     +  M  +     +  +     +     +  +        +        +     +  +  +  +|             
      Leukemia Mononuclear                 |                                        X                                 |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
      Acinus, Adenoma                      |                                                          X        X      |             
      Acinus, Adenoma, Multiple            |                               X                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
      Leukemia Mononuclear                 |                                        X                                 |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
      Sarcoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 6| 7| 1| 7| 6| 1| 7| 1| 7| 4| 1| 4| 7| 4| 4| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 7| 2| 6| 3| 7| 3| 5| 7| 3| 7| 3| 6| 7| 7| 3| 7| 7| 3| 7| 3| 3| 3| 2|             
                                           | 0| 0| 0| 8| 8| 0| 6| 0| 3| 6| 0| 5| 0| 7| 5| 0| 0| 0| 0| 0| 0| 0| 0| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.25%                                  | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
     61LM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +     +  +  +     +  +     +     +  A        +        +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
      Leukemia Mononuclear                 |          X     X        X              X                                X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
      Leukemia Mononuclear                 |                         X              X                                 |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
      Leukemia Mononuclear                 |                         X              X                                 |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              | X                             X     X           X                    X   |             
      Bilateral, Pheochromocytoma Benign   |                                                          X               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +     +  M  +     +  +     +     +  +        +        +     +  +  +  +|             
      Adenoma                              |                                                                         X|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +     +  +  +     +  M     +     M  +        +        +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               |             X  X        X                                            X   |             
      Pars Distalis, Adenoma, Multiple     |                               X                                          |             
      Pars Distalis, Leukemia Mononuclear  |                                        X                                 |             
      Pars Distalis, Lymphoma Malignant    |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
      Pars Intermedia, Lymphoma Malignant  |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +     +  +  +     +  +     +     +  A        +        +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 6| 7| 1| 7| 6| 1| 7| 1| 7| 4| 1| 4| 7| 4| 4| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 7| 2| 6| 3| 7| 3| 5| 7| 3| 7| 3| 6| 7| 7| 3| 7| 7| 3| 7| 3| 3| 3| 2|             
                                           | 0| 0| 0| 8| 8| 0| 6| 0| 3| 6| 0| 5| 0| 7| 5| 0| 0| 0| 0| 0| 0| 0| 0| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.25%                                  | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
     61LM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      C-Cell, Adenoma                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
      Leukemia Mononuclear                 |                                        X                                 |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
      Adenoma                              | X           X  X                    X                             X      |             
      Leukemia Mononuclear                 |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
      Leukemia Mononuclear                 |                                        X                                 |             
      Bilateral, Interstitial Cell, Adenoma| X  X     X     X     X        X     X  X        X        X     X  X  X  X|             
      Interstitial Cell, Adenoma           |                                                                          |             
      Tunic, Mesothelioma Malignant        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
      Leukemia Mononuclear                 |          X     X        X              X                                X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
      Axillary, Lymphoma Malignant         |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |          X     X        X                                X              X|             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
      Pancreatic, Leukemia Mononuclear     |          X                                                              X|             
      Renal, Lymphoma Malignant            |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 6| 7| 1| 7| 6| 1| 7| 1| 7| 4| 1| 4| 7| 4| 4| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 7| 2| 6| 3| 7| 3| 5| 7| 3| 7| 3| 6| 7| 7| 3| 7| 7| 3| 7| 3| 3| 3| 2|             
                                           | 0| 0| 0| 8| 8| 0| 6| 0| 3| 6| 0| 5| 0| 7| 5| 0| 0| 0| 0| 0| 0| 0| 0| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.25%                                  | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
     61LM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +     +  +  +     +  +     +     +  +        M        +     +  +  +  +|             
      Leukemia Mononuclear                 |          X     X        X              X                             X  X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
      Leukemia Mononuclear                 |          X     X                       X                 X     X        X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
      Leukemia Mononuclear                 | X        X     X        X           X  X                 X     X     X  X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
      Sarcoma                              |                                                                      X   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +     +  +  +     +  M     +     +  +        +        +     +  +  +  +|             
      Leukemia Mononuclear                 |          X     X                       X                 X              X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M     +  M  M     M  M     +     +  +        M        M     M  M  M  +|             
      Fibroadenoma                         |                               X                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
      Keratoacanthoma                      | X                                                                        |             
      Leukemia Mononuclear                 |                                                                          |             
      Squamous Cell Papilloma              |          X                                                               |             
      Subcutaneous Tissue, Fibroma         | X        X                                                               |             
      Subcutaneous Tissue, Lipoma          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
      Osteosarcoma                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
      Leukemia Mononuclear                 |                         X              X                                 |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Leukemia Mononuclear                 | X        X     X        X           X  X                 X           X  X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 6| 7| 1| 7| 6| 1| 7| 1| 7| 4| 1| 4| 7| 4| 4| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 7| 2| 6| 3| 7| 3| 5| 7| 3| 7| 3| 6| 7| 7| 3| 7| 7| 3| 7| 3| 3| 3| 2|             
                                           | 0| 0| 0| 8| 8| 0| 6| 0| 3| 6| 0| 5| 0| 7| 5| 0| 0| 0| 0| 0| 0| 0| 0| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.25%                                  | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
     61LM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
      Pheochromocytoma Malignant,          |                                                                          |             
          Metastatic, Adrenal Gland        |                                                                          |             
      Mediastinum, Sarcoma, Metastatic,    |                                                                          |             
           Salivary Glands                 |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
      Leukemia Mononuclear                 |                                        X                                 |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |    +                                                                     |             
      Squamous Cell Carcinoma              |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +                                            +                        |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                 +                        |             
      Adenoma                              |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
      Leukemia Mononuclear                 |                X        X              X                                X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
      Leukemia Mononuclear                 | X        X     X        X           X  X                 X     X     X  X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 1| 7| 7| 7| 4| 7| 6| 7| 7| 3|              |            |
                             DAY ON TEST   | 3| 3| 3| 7| 7| 3| 3| 3| 2| 7| 7| 3| 3| 3| 7| 3| 7| 3| 3| 6|              |            |
                                           | 0| 0| 0| 0| 0| 1| 0| 0| 3| 0| 6| 1| 1| 1| 0| 1| 3| 1| 1| 7|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |     A      |
    0.25%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |     L      |
     61LM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +        +  +  +  +        M  +  +     +  +  +  +  +               |  48        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  48        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  M  +        +  +  +  +        +  +  +     +  +  +  +  +               |  44        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
      Polyp Adenomatous                    | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  M  +        +  +  +  +        +  +  +     +  +  +  +  +               |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  48        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  48        |
      Leukemia Mononuclear                 |                         X                                                |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  47        |
      Leukemia Mononuclear                 |                         X                                                |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  50        |
      Leukemia Mononuclear                 |       X                 X                          X  X                  |         21 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                          X               |          2 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   5        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  48        |
      Leukemia Mononuclear                 |                         X                             X                  |          5 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
      Acinus, Adenoma                      |                                                                          |          3 |
      Acinus, Adenoma, Multiple            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  50        |
      Leukemia Mononuclear                 |                                                                          |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  56                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 1| 7| 7| 7| 4| 7| 6| 7| 7| 3|              |            |
                             DAY ON TEST   | 3| 3| 3| 7| 7| 3| 3| 3| 2| 7| 7| 3| 3| 3| 7| 3| 7| 3| 3| 6|              |            |
                                           | 0| 0| 0| 0| 0| 1| 0| 0| 3| 0| 6| 1| 1| 1| 0| 1| 3| 1| 1| 7|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |     A      |
    0.25%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |     L      |
     61LM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
      Sarcoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +        +  +  +  +        +  +  +     +  +  +  M  +               |  48        |
      Leukemia Mononuclear                 |                                                                          |          3 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
      Squamous Cell Papilloma              |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  48        |
      Leukemia Mononuclear                 |                         X                                                |          4 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  50        |
      Leukemia Mononuclear                 |                         X                             X                  |         12 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  50        |
      Leukemia Mononuclear                 |                                                       X                  |          7 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                          X               |          2 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  49        |
      Leukemia Mononuclear                 |                                                       X                  |          7 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                          X               |          2 |
      Pheochromocytoma Malignant           |                                              X                           |          1 |
      Pheochromocytoma Benign              |                X     X  X                             X                  |         11 |
      Bilateral, Pheochromocytoma Benign   |                                                    X                     |          6 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +        +  +  +  +        +  +  +     +  +  M  +  +               |  47        |
      Adenoma                              |       X                                                                  |          4 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  44        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +        +  +  +  +        +  +  +     +  +  +  +  M               |  49        |
      Leukemia Mononuclear                 |                         X                                                |          1 |
      Pars Distalis, Adenoma               | X              X     X  X        X     X        X                        |         18 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  57                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 1| 7| 7| 7| 4| 7| 6| 7| 7| 3|              |            |
                             DAY ON TEST   | 3| 3| 3| 7| 7| 3| 3| 3| 2| 7| 7| 3| 3| 3| 7| 3| 7| 3| 3| 6|              |            |
                                           | 0| 0| 0| 0| 0| 1| 0| 0| 3| 0| 6| 1| 1| 1| 0| 1| 3| 1| 1| 7|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |     A      |
    0.25%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |     L      |
     61LM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Adenoma, Multiple     |                   X                                                      |          2 |
      Pars Distalis, Leukemia Mononuclear  |                                                                          |          4 |
      Pars Distalis, Lymphoma Malignant    |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
      Pars Intermedia, Lymphoma Malignant  |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
      C-Cell, Adenoma                      |    X                                               X                     |          5 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                      +                                                   |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  50        |
      Adenoma                              |       X                             X                                    |         13 |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  50        |
      Leukemia Mononuclear                 |                                                       X                  |          3 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                          X               |          2 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Bilateral, Interstitial Cell, Adenoma|    X  X        X  X  X  X        X  X  X     X     X  X                  |         40 |
      Interstitial Cell, Adenoma           | X                                               X                        |          3 |
      Tunic, Mesothelioma Malignant        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  58                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 1| 7| 7| 7| 4| 7| 6| 7| 7| 3|              |            |
                             DAY ON TEST   | 3| 3| 3| 7| 7| 3| 3| 3| 2| 7| 7| 3| 3| 3| 7| 3| 7| 3| 3| 6|              |            |
                                           | 0| 0| 0| 0| 0| 1| 0| 0| 3| 0| 6| 1| 1| 1| 0| 1| 3| 1| 1| 7|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |     A      |
    0.25%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |     L      |
     61LM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  50        |
      Leukemia Mononuclear                 |                         X                             X                  |          9 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  50        |
      Axillary, Lymphoma Malignant         |                                                                          |            |
          Undifferentiated Cell Type       |                                                          X               |          1 |
      Lumbar, Lymphoma Malignant           |                                                                          |            |
          Undifferentiated Cell Type       |                                                          X               |          1 |
      Mediastinal, Leukemia Mononuclear    |                         X                          X  X                  |         13 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Undifferentiated Cell Type       |                                                          X               |          2 |
      Pancreatic, Leukemia Mononuclear     |                                                    X                     |          5 |
      Renal, Lymphoma Malignant            |                                                                          |            |
          Undifferentiated Cell Type       |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +        M  +  +  +        +  +  +     +  +  +  +  +               |  46        |
      Leukemia Mononuclear                 |                         X                             X                  |         13 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  50        |
      Leukemia Mononuclear                 |                         X                          X  X                  |         15 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                          X               |          2 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  50        |
      Leukemia Mononuclear                 |       X                 X                          X  X                  |         21 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                          X               |          2 |
      Sarcoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +        +  +  +  +        M  M  +     M  +  +  +  M               |  43        |
      Leukemia Mononuclear                 |                         X                             X                  |         13 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M        M  M  +  M        M  M  +     +  M  +  +  M               |  18        |
      Fibroadenoma                         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  50        |
      Keratoacanthoma                      |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  59                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 1| 7| 7| 7| 4| 7| 6| 7| 7| 3|              |            |
                             DAY ON TEST   | 3| 3| 3| 7| 7| 3| 3| 3| 2| 7| 7| 3| 3| 3| 7| 3| 7| 3| 3| 6|              |            |
                                           | 0| 0| 0| 0| 0| 1| 0| 0| 3| 0| 6| 1| 1| 1| 0| 1| 3| 1| 1| 7|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |     A      |
    0.25%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |     L      |
     61LM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Squamous Cell Papilloma              |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |                   X                    X                                 |          5 |
      Subcutaneous Tissue, Lipoma          |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  50        |
      Osteosarcoma                         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   2        |
      Leukemia Mononuclear                 |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  50        |
      Leukemia Mononuclear                 |                                                                          |          3 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  50        |
      Alveolar/Bronchiolar Adenoma         |                                                    X                     |          1 |
      Leukemia Mononuclear                 |       X                 X                          X  X                  |         19 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                          X               |          2 |
      Osteosarcoma, Metastatic, Bone       |                                                                          |          1 |
      Pheochromocytoma Malignant,          |                                                                          |            |
          Metastatic, Adrenal Gland        |                                              X                           |          1 |
      Mediastinum, Sarcoma, Metastatic,    |                                                                          |            |
           Salivary Glands                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  50        |
      Leukemia Mononuclear                 |                                                                          |          4 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                   +                    +                                 |   4        |
      Squamous Cell Carcinoma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Eye                                     |                   +  +                 +                                 |   6        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
      Adenoma                              |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  60                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 1| 7| 7| 7| 4| 7| 6| 7| 7| 3|              |            |
                             DAY ON TEST   | 3| 3| 3| 7| 7| 3| 3| 3| 2| 7| 7| 3| 3| 3| 7| 3| 7| 3| 3| 6|              |            |
                                           | 0| 0| 0| 0| 0| 1| 0| 0| 3| 0| 6| 1| 1| 1| 0| 1| 3| 1| 1| 7|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |     A      |
    0.25%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |     L      |
     61LM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  50        |
      Leukemia Mononuclear                 |       X                 X                          X  X                  |         13 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                          X               |          2 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  48        |
      Leukemia Mononuclear                 |                                                       X                  |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  50        |
      Leukemia Mononuclear                 |       X                 X                          X  X                  |         21 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                          X               |          2 |
      Mesothelioma Malignant               |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  61                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 7| 7| 1| 7| 1| 6| 7| 7| 6| 6| 4| 0| 7| 7| 7| 1| 7| 7| 4| 6| 1|             
                             DAY ON TEST   | 2| 7| 2| 2| 2| 2| 7| 2| 7| 6| 2| 2| 9| 5| 7| 5| 2| 2| 0| 7| 2| 2| 7| 7| 7|             
                                           | 9| 0| 9| 9| 9| 9| 5| 9| 6| 8| 9| 9| 4| 4| 0| 2| 9| 9| 4| 5| 9| 9| 0| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.5%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    61HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +     +  +  +  +     +     +  +  +  +  A        +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +     +  +  +  +     +     A  +  +  +  A        +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +  +  +  +     +     +  +  +  M  M        +  +  +     M  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +     +  +  +  +     +     A  +  +  +  A        +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +     +  +  +  +     +     +  +  +  +  A        +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     +  +  +  +     +     +  +  +  +  A        +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +     +  +  +  +     +     A  +  +  +  A        +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +     +  +  +  +     +     A  +  +  +  A        +  +  +     +  +     +   |             
      Sarcoma                              |             X                                                            |             
                                            __________________________________________________________________________|             
   Liver                                   | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
      Adenocarcinoma, Metastatic, Lung     |                                        X                                 |             
      Leukemia Mononuclear                 | X           X              X        X           X           X  X         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +  +  +  +     +     +  +  +  +  M        +  +  +     +  +     +   |             
      Leukemia Mononuclear                 |                                                                          |             
      Acinus, Adenoma                      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +  +  +  +     +     A  +  +  +  +        +  +  +     +  +     +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Tongue                                  | +                                                                        |             
      Squamous Cell Papilloma              | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
      Leukemia Mononuclear                 |                            X                    X                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
      Leukemia Mononuclear                 |                            X                    X                        |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
      Leukemia Mononuclear                 |                            X                    X                        |             
      Pheochromocytoma Benign              |       X                    X  X  X              X                    X   |             
      Bilateral, Pheochromocytoma Benign   |                                     X                          X         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +  +  +  +     +     +  +  +  +  M        +  +  +     +  +     +   |             
      Adenoma                              |                                                       X                  |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +     M  +  +  +     +     +  +  +  +  +        +  +  +     M  +     +   |             
      Adenoma                              |                X                                                         |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
      Leukemia Mononuclear                 |                                                 X                        |             
      Pars Distalis, Adenoma               | X     X  X     X     X           X  X           X  X  X        X     X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 7| 7| 1| 7| 1| 6| 7| 7| 6| 6| 4| 0| 7| 7| 7| 1| 7| 7| 4| 6| 1|             
                             DAY ON TEST   | 2| 7| 2| 2| 2| 2| 7| 2| 7| 6| 2| 2| 9| 5| 7| 5| 2| 2| 0| 7| 2| 2| 7| 7| 7|             
                                           | 9| 0| 9| 9| 9| 9| 5| 9| 6| 8| 9| 9| 4| 4| 0| 2| 9| 9| 4| 5| 9| 9| 0| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.5%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    61HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Adenoma, Multiple     |                                                                          |             
      Pars Distalis, Leukemia Mononuclear  |                                                                          |             
      Pars Distalis, Lymphoma Malignant    |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +     +  +  +  +     +     A  +  +  +  +        +  +  +     +  +     +   |             
      C-Cell, Adenoma                      | X                                X                                       |             
      Follicular Cell, Adenoma             |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
      Bilateral, Adenoma                   |                X                                                         |             
                                            __________________________________________________________________________|             
   Prostate                                | +     +  +  +  +     +     +  +  +  M  +        +  +  +     M  +     +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Testes                                  | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
      Leukemia Mononuclear                 |                                                                          |             
      Bilateral, Interstitial Cell, Adenoma| X     X  X  X  X     X     X  X        X        X           X  X     X   |             
      Interstitial Cell, Adenoma           |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +  +  +  +     +     A  +  +  +  +        +  +  +     +  +     +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
      Axillary, Leukemia Mononuclear       |                                                 X                        |             
      Mediastinal, Leukemia Mononuclear    |                            X                    X                        |             
      Pancreatic, Leukemia Mononuclear     |                                                 X                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +     +  +  +  +     +     M  +  +  +  +        +  +  +     +  +     +   |             
      Leukemia Mononuclear                 |                                                 X                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | M     +  +  M  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
      Leukemia Mononuclear                 |                            X                    X                        |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
      Leukemia Mononuclear                 | X           X              X        X           X           X  X         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
      Leukemia Mononuclear                 |                            X                    X                        |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +     +  +  M  +     M     M  M  +  +  M        +  +  +     M  M     +   |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 7| 7| 1| 7| 1| 6| 7| 7| 6| 6| 4| 0| 7| 7| 7| 1| 7| 7| 4| 6| 1|             
                             DAY ON TEST   | 2| 7| 2| 2| 2| 2| 7| 2| 7| 6| 2| 2| 9| 5| 7| 5| 2| 2| 0| 7| 2| 2| 7| 7| 7|             
                                           | 9| 0| 9| 9| 9| 9| 5| 9| 6| 8| 9| 9| 4| 4| 0| 2| 9| 9| 4| 5| 9| 9| 0| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.5%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    61HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
      Keratoacanthoma                      |                      X                                                   |             
      Leukemia Mononuclear                 |                                                                          |             
      Squamous Cell Carcinoma              |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
      Astrocytoma Malignant                |                                                                          |             
      Leukemia Mononuclear                 |                            X                                             |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
      Adenocarcinoma                       |                                        X                                 |             
      Alveolar/Bronchiolar Adenoma         |       X                                                        X         |             
      Leukemia Mononuclear                 | X                                   X           X           X            |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
      Mediastinum, Adenocarcinoma,         |                                                                          |             
          Metastatic, Lung                 |                                        X                                 |             
                                            __________________________________________________________________________|             
   Nose                                    | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                       +                  |             
                                            __________________________________________________________________________|             
   Eye                                     |                      +           +                 +  +                  |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                       +                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
      Adenocarcinoma, Metastatic, Lung     |                                        X                                 |             
      Leukemia Mononuclear                 | X                          X        X           X              X         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +  +  +  +     +     +  +  +  +  +        +  +  +     M  +     +   |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
      Leukemia Mononuclear                 | X           X              X        X           X           X  X         |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
 _____________________________________________________________________________________________________________________              
                                           | 7| 1| 6| 1| 1| 1| 7| 7| 7| 7| 1| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 3|             
                             DAY ON TEST   | 1| 7| 9| 7| 7| 7| 2| 2| 2| 2| 7| 7| 2| 1| 8| 2| 2| 2| 2| 2| 3| 0| 9| 5| 6|             
                                           | 4| 5| 4| 6| 5| 6| 9| 9| 9| 9| 6| 0| 9| 5| 8| 9| 9| 9| 9| 9| 0| 2| 4| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.5%                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    61HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sarcoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Metastatic, Lung     |                                                                          |             
      Leukemia Mononuclear                 |       X                                X  X              X     X  X      |             
                                            __________________________________________________________________________|             
   Mesentery                               |       M                                                                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Acinus, Adenoma                      |                            X                                         X   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tongue                                  |                                        +                                 |             
      Squamous Cell Papilloma              |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pheochromocytoma Benign              | X     X           X        X        X                 X                  |             
      Bilateral, Pheochromocytoma Benign   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                          X               |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M     +           +  +  M  +        +  +  +  M  M  +  +  +  +  +  M  +  +|             
      Adenoma                              |                                                             X            |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               |                   X                 X  X  X           X  X     X  X     X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
 _____________________________________________________________________________________________________________________              
                                           | 7| 1| 6| 1| 1| 1| 7| 7| 7| 7| 1| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 3|             
                             DAY ON TEST   | 1| 7| 9| 7| 7| 7| 2| 2| 2| 2| 7| 7| 2| 1| 8| 2| 2| 2| 2| 2| 3| 0| 9| 5| 6|             
                                           | 4| 5| 4| 6| 5| 6| 9| 9| 9| 9| 6| 0| 9| 5| 8| 9| 9| 9| 9| 9| 0| 2| 4| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.5%                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    61HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Adenoma, Multiple     |                                                                          |             
      Pars Distalis, Leukemia Mononuclear  |                                                                          |             
      Pars Distalis, Lymphoma Malignant    |                                                                          |             
          Undifferentiated Cell Type       |                                           X                              |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                                              X  X           X            |             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                            X              X                              |             
      Leukemia Mononuclear                 |                                                                          |             
      Bilateral, Adenoma                   |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Bilateral, Interstitial Cell, Adenoma| X     X           X  X  X  X        X  X     X  X  X  X  X  X     X  X   |             
      Interstitial Cell, Adenoma           |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Axillary, Leukemia Mononuclear       |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |                                           X              X        X      |             
      Pancreatic, Leukemia Mononuclear     |                                           X                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +     +           +  +  +  +        +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                           X                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                           X              X               |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                                X  X              X     X  X      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +     +           +  +  +  +        M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M     M           M  +  M  M        M  M  M  +  M  +  +  M  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
 _____________________________________________________________________________________________________________________              
                                           | 7| 1| 6| 1| 1| 1| 7| 7| 7| 7| 1| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 3|             
                             DAY ON TEST   | 1| 7| 9| 7| 7| 7| 2| 2| 2| 2| 7| 7| 2| 1| 8| 2| 2| 2| 2| 2| 3| 0| 9| 5| 6|             
                                           | 4| 5| 4| 6| 5| 6| 9| 9| 9| 9| 6| 0| 9| 5| 8| 9| 9| 9| 9| 9| 0| 2| 4| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.5%                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    61HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | M     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Keratoacanthoma                      |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
      Squamous Cell Carcinoma              |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Astrocytoma Malignant                |       X                                                                  |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                      +   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                                                                          |             
      Alveolar/Bronchiolar Adenoma         |                                              X                           |             
      Leukemia Mononuclear                 |                                                          X     X  X      |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                           X                              |             
      Mediastinum, Adenocarcinoma,         |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                +         |             
                                            __________________________________________________________________________|             
   Eye                                     | +                          +                                            +|             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                            +                                             |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Metastatic, Lung     |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                                X  X              X     X  X      |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 4| 4| 4| 7| 4| 7| 6| 4| 7| 6| 5| 5| 4| 7| 4| 4| 1| 6|              |            |
                             DAY ON TEST   | 3| 5| 7| 3| 3| 3| 7| 2| 0| 7| 3| 9| 7| 5| 7| 3| 7| 7| 7| 8|              |            |
                                           | 0| 3| 0| 6| 0| 0| 0| 9| 5| 0| 0| 6| 0| 7| 0| 0| 0| 0| 5| 0|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |     A      |
    0.5%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |     L      |
    61HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +     +  +  +     +  +     +  +  +  +     +           +               |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +     +  +  +     +  +     +  +  +  +     +           +               |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +     +  +  +     +  +     +  +  +  A     +           +               |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +     +  +  +     +  +     +  +  +  A     +           +               |  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +     +  +  +     +  +     +  +  +  +     +           +               |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +     +  +  +     +  +     +  +  +  A     +           +               |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +     +  +  +     +  +     +  +  +  A     +           +               |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +     +  +  +     +  +     +  +  +  A     +           +               |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +     +  +  +     +  +     +  +  +  A     +           +               |  46        |
      Sarcoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +     +  +  +     +  +     +  +  +  +     +           +               |  49        |
      Adenocarcinoma, Metastatic, Lung     |                                                                          |          1 |
      Leukemia Mononuclear                 |                         X           X                    X               |         16 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |             M                          +                                 |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +     +  +  +     +  +     +  +  +  +     +           +               |  48        |
      Leukemia Mononuclear                 |                         X           X                                    |          2 |
      Acinus, Adenoma                      |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +     +  +  +     +  +     +  +  +  +     +           +               |  48        |
      Leukemia Mononuclear                 |                                     X                                    |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +     +  +  +     +  +     +  +  +  +     +           +               |  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +     +  +  +     +  +     +  +  +  +     +           +               |  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +     +  +  +     +  +     +  +  +  A     +           +               |  48        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |          +                                                               |   3        |
      Squamous Cell Papilloma              |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +     +  +  +     +  +     +  +  +  +     +           +               |  49        |
      Leukemia Mononuclear                 |                         X           X                                    |          5 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +     +  M  +     +  +     +  +  +  +     +           +               |  48        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +     +  M  +     +  +     +  +  +  +     +           +               |  48        |
      Leukemia Mononuclear                 |                         X           X                    X               |          5 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +     +  M  +     +  +     +  +  +  +     +           +               |  48        |
      Leukemia Mononuclear                 |                         X           X                    X               |          5 |
      Pheochromocytoma Benign              |                               X     X                                    |         14 |
      Bilateral, Pheochromocytoma Benign   |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +     +  +  +     +  +     +  +  +  +     +           +               |  48        |
      Adenoma                              |                                     X                                    |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  68                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 4| 4| 4| 7| 4| 7| 6| 4| 7| 6| 5| 5| 4| 7| 4| 4| 1| 6|              |            |
                             DAY ON TEST   | 3| 5| 7| 3| 3| 3| 7| 2| 0| 7| 3| 9| 7| 5| 7| 3| 7| 7| 7| 8|              |            |
                                           | 0| 3| 0| 6| 0| 0| 0| 9| 5| 0| 0| 6| 0| 7| 0| 0| 0| 0| 5| 0|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |     A      |
    0.5%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |     L      |
    61HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +     +  M        M  +     M  +  +  M     +           +               |  37        |
      Adenoma                              |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +     +  +  +     +  +     +  +  +  +     +           +               |  49        |
      Leukemia Mononuclear                 |                                                          X               |          2 |
      Pars Distalis, Adenoma               |    X                                X  X     X           X               |         26 |
      Pars Distalis, Adenoma, Multiple     |                X                 X                                       |          2 |
      Pars Distalis, Leukemia Mononuclear  |                         X           X                                    |          2 |
      Pars Distalis, Lymphoma Malignant    |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +     +  +  +     +  +     +  +  +  +     +           +               |  48        |
      C-Cell, Adenoma                      |                X                                                         |          6 |
      Follicular Cell, Adenoma             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +     +  +  +     +  +     +  +  +  +     +           +               |  49        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +     +  +  +     +  +     +  +  +  +     +           +               |  49        |
      Adenoma                              | X  X           X     X           X                                       |          7 |
      Leukemia Mononuclear                 |                         X           X                                    |          2 |
      Bilateral, Adenoma                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +     +  +  +     +  +     +  +  +  +     +           +               |  46        |
      Leukemia Mononuclear                 |                                     X                                    |          1 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +     +  +  +     +  +     +  +  +  +     +           +               |  48        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +     +  +  +     +  +     +  +  +  +     +           +               |  49        |
      Leukemia Mononuclear                 |                         X           X                                    |          2 |
      Bilateral, Interstitial Cell, Adenoma| X              X     X  X     X              X           X               |         36 |
      Interstitial Cell, Adenoma           |    X     X                             X                                 |          5 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +     +  +  +     +  +     +  +  +  +     +           +               |  48        |
      Leukemia Mononuclear                 |                         X           X                                    |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +     +  +  +     +  +     +  +  +  +     +           +               |  49        |
      Axillary, Leukemia Mononuclear       |                                                                          |          1 |
      Mediastinal, Leukemia Mononuclear    |                                     X                                    |          6 |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M     +  +  +     +  +     +  +  +  +     +           +               |  46        |
      Leukemia Mononuclear                 |                                     X                                    |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  69                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 4| 4| 4| 7| 4| 7| 6| 4| 7| 6| 5| 5| 4| 7| 4| 4| 1| 6|              |            |
                             DAY ON TEST   | 3| 5| 7| 3| 3| 3| 7| 2| 0| 7| 3| 9| 7| 5| 7| 3| 7| 7| 7| 8|              |            |
                                           | 0| 3| 0| 6| 0| 0| 0| 9| 5| 0| 0| 6| 0| 7| 0| 0| 0| 0| 5| 0|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |     A      |
    0.5%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |     L      |
    61HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +     +  +  +     +  +     +  +  +  +     +           +               |  47        |
      Leukemia Mononuclear                 |                         X           X                                    |          6 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +     +  +  +     +  +     +  +  +  A     +           +               |  48        |
      Leukemia Mononuclear                 |                         X           X                    X               |         16 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +     +  +  +     +  +     +  +  M  +     +           +               |  47        |
      Leukemia Mononuclear                 |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +     +  +  M     M  M     M  +  M  +     +           +               |  26        |
      Adenoma                              |                                              X                           |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +     +  +  +     +  +     +  +  +  +     M           +               |  47        |
      Keratoacanthoma                      |                                                                          |          1 |
      Leukemia Mononuclear                 |                         X           X                                    |          2 |
      Squamous Cell Carcinoma              |          X                                                               |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +     +  +  +     +  +     +  +  +  +     +           +               |  49        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +     +  +  +     +  +     +  +  +  +     +           +               |  49        |
      Astrocytoma Malignant                |                                                                          |          1 |
      Leukemia Mononuclear                 |                         X           X                                    |          3 |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +     +  +  +     +  +     +  +  +  +     +           +               |  49        |
      Adenocarcinoma                       |                                                                          |          1 |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          3 |
      Leukemia Mononuclear                 |                         X           X                    X               |         10 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
      Mediastinum, Adenocarcinoma,         |                                                                          |            |
          Metastatic, Lung                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +     +  +  +     +  +     +  +  +  +     +           +               |  49        |
      Leukemia Mononuclear                 |                         X                                                |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +     +  +  +     +  +     +  +  +  +     +           +               |  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  70                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 4| 4| 4| 7| 4| 7| 6| 4| 7| 6| 5| 5| 4| 7| 4| 4| 1| 6|              |            |
                             DAY ON TEST   | 3| 5| 7| 3| 3| 3| 7| 2| 0| 7| 3| 9| 7| 5| 7| 3| 7| 7| 7| 8|              |            |
                                           | 0| 3| 0| 6| 0| 0| 0| 9| 5| 0| 0| 6| 0| 7| 0| 0| 0| 0| 5| 0|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |     A      |
    0.5%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |     L      |
    61HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Eye                                     | +                       +     +  +           +                           |  12        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +                             +  +           +                           |   6        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +     +  +  +     +  +     +  +  +  +     +           +               |  49        |
      Adenocarcinoma, Metastatic, Lung     |                                                                          |          1 |
      Leukemia Mononuclear                 |                         X           X                    X               |          8 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +     +  +  +     +  +     +  +  +  A     +           +               |  47        |
      Leukemia Mononuclear                 |                                     X                                    |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +     +  +  +     +  +     +  +  +  +     +           +               |  49        |
      Leukemia Mononuclear                 |                         X           X                    X               |         16 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  71                                                               
                                  ------------------------------------------------------------                                      
                                  ----------              END OF REPORT             ----------                                      
                                  ------------------------------------------------------------