Skip to Main Navigation
Skip to Page Content

COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/2389

TDMS Study 05057-01 Pathology Tables

NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97
Route: DOSED FEED                                                                                                 Time: 11:18:18




       Facility:  TSI Mason Research

       Chemical CAS #:  5982043-8

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































Note:  Animals arranged according to CID number

                                                              Page   1

NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 1| 7| 6| 4| 7| 1| 7| 7| 4| 1| 7| 1| 7| 4| 7| 6| 4| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 0| 6| 8| 3| 4| 6| 3| 8| 2| 1| 6| 8| 3| 8| 3| 6| 3| 4| 6| 2| 3|             
                                           | 5| 5| 6| 6| 1| 4| 3| 5| 7| 4| 5| 2| 8| 0| 4| 3| 5| 3| 1| 4| 5| 5| 4| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    UNTREATE                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    D 61UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +        +  +     M     +  +        +     +     +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +        +  +     +     +  +        +     M     +  +     +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
      Hepatocellular Carcinoma             |                                                       X                  |             
      Leukemia Mononuclear                 |                                                 X     X                 X|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                        +                                 |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Acinus, Adenoma                      |          X                          X                                    |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
      Leukemia Mononuclear                 |                                                       X                 X|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
      Adenoma                              |                      X                                                   |             
      Leukemia Mononuclear                 |                                                       X                 X|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
      Leukemia Mononuclear                 |                                                       X                 X|             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
      Adenoma                              |                               X                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +        +  +     M     +  M        +     M     +  +     +  +|             
      Adenoma                              |                                     X                                    |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
      Pars Distalis, Adenoma               | X  X  X  X  X        X  X           X                 X        X        X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 1| 7| 6| 4| 7| 1| 7| 7| 4| 1| 7| 1| 7| 4| 7| 6| 4| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 0| 6| 8| 3| 4| 6| 3| 8| 2| 1| 6| 8| 3| 8| 3| 6| 3| 4| 6| 2| 3|             
                                           | 5| 5| 6| 6| 1| 4| 3| 5| 7| 4| 5| 2| 8| 0| 4| 3| 5| 3| 1| 4| 5| 5| 4| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    UNTREATE                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    D 61UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Adenoma, Multiple     |                               X                 X                        |             
      Pars Distalis, Carcinoma             |                                        X                                 |             
      Pars Distalis, Leukemia Mononuclear  |                                                                         X|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      C-Cell, Adenoma                      | X        X                    X                                X         |             
      C-Cell, Carcinoma                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +        +  +     M     +  +        +     +     +  +     +  +|             
      Adenoma                              |                                                                X     X   |             
      Bilateral, Adenoma                   |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
      Leukemia Mononuclear                 |                                                                         X|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Polyp Stromal                        |                                     X                                X   |             
      Cervix, Leukemia Mononuclear         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
      Mediastinal, Carcinoma, Metastatic,  |                                                                          |             
           Thyroid Gland                   |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |                                                       X                 X|             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
      Renal, Leukemia Mononuclear          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +        +  M     +     +  +        +     +     +  +     +  +|             
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |             
          Gland                            |                                                                          |             
      Leukemia Mononuclear                 |                                                       X                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
      Leukemia Mononuclear                 |                                                       X                 X|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
      Leukemia Mononuclear                 |                                                 X     X                 X|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +        M  +     +     M  +        +     +     +  +     +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 1| 7| 6| 4| 7| 1| 7| 7| 4| 1| 7| 1| 7| 4| 7| 6| 4| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 0| 6| 8| 3| 4| 6| 3| 8| 2| 1| 6| 8| 3| 8| 3| 6| 3| 4| 6| 2| 3|             
                                           | 5| 5| 6| 6| 1| 4| 3| 5| 7| 4| 5| 2| 8| 0| 4| 3| 5| 3| 1| 4| 5| 5| 4| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    UNTREATE                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    D 61UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Adenocarcinoma                       |                                                                          |             
      Adenoma                              |                                                                          |             
      Fibroadenoma                         |          X  X                                   X     X     X        X   |             
      Fibroadenoma, Multiple               |    X                    X     X                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
      Basal Cell Carcinoma                 |                                                 X                        |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Lipoma          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
      Carcinoma, Metastatic, Pituitary     |                                                                          |             
          Gland                            |                                        X                                 |             
      Leukemia Mononuclear                 |                                                                          |             
      Oligodendroglioma Malignant          |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                +         |             
      Neoplasm NOS                         |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |             
          Gland                            |                                                                          |             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                                                          |             
      Leukemia Mononuclear                 |                                                       X                 X|             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Nose                            |             X                                                            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
      Leukemia Mononuclear                 |                                                                         X|             
      Squamous Cell Carcinoma              |             X                                                            |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      Fibroma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |             +           +                                                |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                         +                                                |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 1| 7| 6| 4| 7| 1| 7| 7| 4| 1| 7| 1| 7| 4| 7| 6| 4| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 0| 6| 8| 3| 4| 6| 3| 8| 2| 1| 6| 8| 3| 8| 3| 6| 3| 4| 6| 2| 3|             
                                           | 5| 5| 6| 6| 1| 4| 3| 5| 7| 4| 5| 2| 8| 0| 4| 3| 5| 3| 1| 4| 5| 5| 4| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    UNTREATE                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    D 61UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
      Leukemia Mononuclear                 |                                                       X                 X|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +        +  +     +     +  +        +     +     +  +     +  +|             
      Leukemia Mononuclear                 |                                                 X     X                 X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 6| 4| 7| 1| 6| 4| 4| 7| 7| 7| 7| 6| 7| 7| 1| 7| 6| 1| 7| 7| 4| 7|             
                             DAY ON TEST   | 3| 6| 3| 9| 4| 3| 8| 5| 6| 2| 3| 3| 2| 1| 1| 3| 3| 8| 0| 9| 8| 3| 3| 6| 3|             
                                           | 5| 4| 6| 9| 7| 5| 3| 8| 4| 2| 5| 6| 3| 0| 2| 5| 5| 3| 0| 2| 2| 5| 5| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATE                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    D 61UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +     +  +  +  +     +     A  +  +  +  +  +  +  +     +  +     +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
      Leukemia Mononuclear                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +     +  +  +  +     +     +  +  M  +  +  +  +  +     +  +     +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
      Leukemia Mononuclear                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +     +  +  +  +     +     A  +  +  +  +  +  +  +     +  +     +  +     +|             
                                            __________________________________________________________________________|             
   Liver                                   | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
      Hepatocellular Carcinoma             |                                                                          |             
      Leukemia Mononuclear                 |          X  X                    X              X     X  X               |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +                                                            |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
      Acinus, Adenoma                      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
      Leukemia Mononuclear                 |          X  X                                         X  X               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |          X                       X                       X               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
      Leukemia Mononuclear                 |          X                       X                       X               |             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              |                                  X                                       |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
      Pars Distalis, Adenoma               | X     X     X  X     X        X     X  X  X           X        X  X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 6| 4| 7| 1| 6| 4| 4| 7| 7| 7| 7| 6| 7| 7| 1| 7| 6| 1| 7| 7| 4| 7|             
                             DAY ON TEST   | 3| 6| 3| 9| 4| 3| 8| 5| 6| 2| 3| 3| 2| 1| 1| 3| 3| 8| 0| 9| 8| 3| 3| 6| 3|             
                                           | 5| 4| 6| 9| 7| 5| 3| 8| 4| 2| 5| 6| 3| 0| 2| 5| 5| 3| 0| 2| 2| 5| 5| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATE                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    D 61UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Adenoma, Multiple     |                                                                          |             
      Pars Distalis, Carcinoma             |                                                                          |             
      Pars Distalis, Leukemia Mononuclear  |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
      C-Cell, Adenoma                      |                      X                 X     X                           |             
      C-Cell, Carcinoma                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | M     +  +  +  +     +     +  +  +  +  +  M  +  +     +  +     +  +     +|             
      Adenoma                              |                      X        X                                          |             
      Bilateral, Adenoma                   |                                                       X                  |             
                                            __________________________________________________________________________|             
   Ovary                                   | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
      Leukemia Mononuclear                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Uterus                                  | +     M  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
      Leukemia Mononuclear                 |          X                                                               |             
      Polyp Stromal                        |                                     X                                    |             
      Cervix, Leukemia Mononuclear         |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
      Leukemia Mononuclear                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
      Mediastinal, Carcinoma, Metastatic,  |                                                                          |             
           Thyroid Gland                   |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |          X                                               X               |             
      Pancreatic, Leukemia Mononuclear     |          X  X                                         X                  |             
      Renal, Leukemia Mononuclear          |             X                                            X               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |             
          Gland                            |                                                                          |             
      Leukemia Mononuclear                 |          X  X                    X                    X                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     M  +     +|             
      Leukemia Mononuclear                 |          X  X                    X                    X  X               |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
      Leukemia Mononuclear                 |          X  X                    X              X     X  X               |             
                                            __________________________________________________________________________|             
   Thymus                                  | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
      Leukemia Mononuclear                 |          X                       X                       X               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +     +  +  M  +     +     M  +  +  +  +  +  +  +     +  +     +  +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 6| 4| 7| 1| 6| 4| 4| 7| 7| 7| 7| 6| 7| 7| 1| 7| 6| 1| 7| 7| 4| 7|             
                             DAY ON TEST   | 3| 6| 3| 9| 4| 3| 8| 5| 6| 2| 3| 3| 2| 1| 1| 3| 3| 8| 0| 9| 8| 3| 3| 6| 3|             
                                           | 5| 4| 6| 9| 7| 5| 3| 8| 4| 2| 5| 6| 3| 0| 2| 5| 5| 3| 0| 2| 2| 5| 5| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATE                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    D 61UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Adenocarcinoma                       |                                                                          |             
      Adenoma                              |                X                                      X                  |             
      Fibroadenoma                         | X              X              X     X     X  X           X               |             
      Fibroadenoma, Multiple               |       X  X                                                               |             
                                            __________________________________________________________________________|             
   Skin                                    | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
      Basal Cell Carcinoma                 |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                                        X                                 |             
      Subcutaneous Tissue, Lipoma          |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
      Carcinoma, Metastatic, Pituitary     |                                                                          |             
          Gland                            |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
      Oligodendroglioma Malignant          |                            X                                             |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
      Neoplasm NOS                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |             
          Gland                            |                                                                          |             
      Alveolar/Bronchiolar Adenoma         |                      X                                                   |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |          X                                                               |             
      Leukemia Mononuclear                 |          X  X                    X                    X  X               |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Nose                            |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
      Squamous Cell Carcinoma              |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |       +                                                                  |             
      Fibroma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +     +  +           +           +     +  +                              |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +     +  +           +           +     +                                 |             
      Adenoma                              |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 6| 4| 7| 1| 6| 4| 4| 7| 7| 7| 7| 6| 7| 7| 1| 7| 6| 1| 7| 7| 4| 7|             
                             DAY ON TEST   | 3| 6| 3| 9| 4| 3| 8| 5| 6| 2| 3| 3| 2| 1| 1| 3| 3| 8| 0| 9| 8| 3| 3| 6| 3|             
                                           | 5| 4| 6| 9| 7| 5| 3| 8| 4| 2| 5| 6| 3| 0| 2| 5| 5| 3| 0| 2| 2| 5| 5| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATE                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    D 61UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
      Leukemia Mononuclear                 |          X  X                                                            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +  +  +  +     +     A  +  +  +  +  +  +  +     +  +     +  +     +|             
      Leukemia Mononuclear                 |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +     +  +  +  +     +     +  +  +  +  +  +  +  +     +  +     +  +     +|             
      Leukemia Mononuclear                 |          X  X                    X              X     X  X               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 5| 7| 4| 7| 6| 6| 7| 4| 1| 7| 4| 1| 7| 7| 6| 1|              |            |
                             DAY ON TEST   | 3| 3| 0| 5| 8| 3| 6| 3| 5| 0| 3| 6| 8| 3| 0| 8| 3| 3| 5| 8|              |            |
                                           | 5| 5| 2| 0| 2| 5| 4| 6| 8| 0| 5| 4| 3| 5| 9| 3| 5| 5| 8| 2|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |     A      |
    UNTREATE                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |     L      |
    D 61UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +     +  +  A  +        +  +     +  +  +                  |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +     +  +  A  M        +  +     +  +  +                  |  48        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +     +  +  A  +        +  +     +  +  +                  |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +     +  +  A  +        +  +     +  +  +                  |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +     +  +  A  +        +  +     +  +  +                  |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +     +  +  A  +        +  +     +  +  +                  |  47        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  50        |
      Hepatocellular Carcinoma             |                                                                          |          1 |
      Leukemia Mononuclear                 |       X  X                                      X  X  X                  |         14 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                 +                        |   3        |
      Leukemia Mononuclear                 |                                                 X                        |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +     +  +  A  +        +  +     +  +  +                  |  49        |
      Leukemia Mononuclear                 |                                                 X                        |          1 |
      Acinus, Adenoma                      |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  50        |
      Leukemia Mononuclear                 |                                                 X                        |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  50        |
      Leukemia Mononuclear                 |       X  X                                      X     X                  |         10 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  50        |
      Adenoma                              |                                                                          |          1 |
      Leukemia Mononuclear                 |          X                                            X                  |          7 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +     +  +  M  +        +  +     +  +  +                  |  49        |
      Leukemia Mononuclear                 |          X                                            X                  |          7 |
      Pheochromocytoma Malignant           |                                                 X                        |          1 |
      Pheochromocytoma Benign              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  10                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 5| 7| 4| 7| 6| 6| 7| 4| 1| 7| 4| 1| 7| 7| 6| 1|              |            |
                             DAY ON TEST   | 3| 3| 0| 5| 8| 3| 6| 3| 5| 0| 3| 6| 8| 3| 0| 8| 3| 3| 5| 8|              |            |
                                           | 5| 5| 2| 0| 2| 5| 4| 6| 8| 0| 5| 4| 3| 5| 9| 3| 5| 5| 8| 2|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |     A      |
    UNTREATE                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |     L      |
    D 61UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +     +  +  +  M        +  +     +  +  +                  |  46        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +     +  +  A  +        +  +     +  +  +                  |  49        |
      Pars Distalis, Adenoma               |    X     X  X  X        X     X                    X  X                  |         31 |
      Pars Distalis, Adenoma, Multiple     |                                                                          |          2 |
      Pars Distalis, Carcinoma             |                                                                          |          1 |
      Pars Distalis, Leukemia Mononuclear  |                                                 X     X                  |          3 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  50        |
      Leukemia Mononuclear                 |                                                 X                        |          1 |
      C-Cell, Adenoma                      |                      X  X                                                |          9 |
      C-Cell, Carcinoma                    |                            X                                             |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  47        |
      Adenoma                              |                                        X           X                     |          6 |
      Bilateral, Adenoma                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  50        |
      Leukemia Mononuclear                 |          X                                      X     X                  |          5 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +     +  +  A  +        +  +     +  +  +                  |  48        |
      Leukemia Mononuclear                 |                                                 X                        |          2 |
      Polyp Stromal                        |                                                       X                  |          4 |
      Cervix, Leukemia Mononuclear         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  50        |
      Leukemia Mononuclear                 |                                                       X                  |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  50        |
      Mediastinal, Carcinoma, Metastatic,  |                                                                          |            |
           Thyroid Gland                   |                            X                                             |          1 |
      Mediastinal, Leukemia Mononuclear    |          X                                      X     X                  |          7 |
      Pancreatic, Leukemia Mononuclear     |          X                                      X                        |          5 |
      Renal, Leukemia Mononuclear          |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  49        |
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |            |
          Gland                            |                                           X                              |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  11                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 5| 7| 4| 7| 6| 6| 7| 4| 1| 7| 4| 1| 7| 7| 6| 1|              |            |
                             DAY ON TEST   | 3| 3| 0| 5| 8| 3| 6| 3| 5| 0| 3| 6| 8| 3| 0| 8| 3| 3| 5| 8|              |            |
                                           | 5| 5| 2| 0| 2| 5| 4| 6| 8| 0| 5| 4| 3| 5| 9| 3| 5| 5| 8| 2|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |     A      |
    UNTREATE                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |     L      |
    D 61UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |                                                 X     X                  |          7 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  49        |
      Leukemia Mononuclear                 |       X  X                                      X     X                  |         11 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  50        |
      Leukemia Mononuclear                 |       X  X                                      X  X  X                  |         14 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +     +  +  M  +        +  +     +  +  +                  |  47        |
      Leukemia Mononuclear                 |          X                                      X     X                  |          7 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  48        |
      Adenocarcinoma                       |                                           X                              |          1 |
      Adenoma                              |    X                                                                     |          3 |
      Fibroadenoma                         |    X        X  X     X        X        X                                 |         19 |
      Fibroadenoma, Multiple               | X                       X                       X     X                  |          9 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +     +  M  +  +        +  +     M  +  +                  |  48        |
      Basal Cell Carcinoma                 |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |                                                                          |          1 |
      Subcutaneous Tissue, Lipoma          |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                 +                        |   1        |
      Leukemia Mononuclear                 |                                                 X                        |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  50        |
      Carcinoma, Metastatic, Pituitary     |                                                                          |            |
          Gland                            |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                       X                  |          1 |
      Oligodendroglioma Malignant          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
      Neoplasm NOS                         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  50        |
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |            |
          Gland                            |                                           X                              |          1 |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          1 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  12                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 5| 7| 4| 7| 6| 6| 7| 4| 1| 7| 4| 1| 7| 7| 6| 1|              |            |
                             DAY ON TEST   | 3| 3| 0| 5| 8| 3| 6| 3| 5| 0| 3| 6| 8| 3| 0| 8| 3| 3| 5| 8|              |            |
                                           | 5| 5| 2| 0| 2| 5| 4| 6| 8| 0| 5| 4| 3| 5| 9| 3| 5| 5| 8| 2|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |     A      |
    UNTREATE                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |     L      |
    D 61UF                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
          Multiple                         |                                                                          |          1 |
      Leukemia Mononuclear                 |       X  X                                      X     X                  |         11 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Nose                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  50        |
      Leukemia Mononuclear                 |          X                                                               |          2 |
      Squamous Cell Carcinoma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     | +                                                                        |   2        |
      Fibroma                              | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Eye                                     |    +                    +     +                                          |  12        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |    +                          +                                          |   9        |
      Adenoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +     +  +  A  +        +  +     +  +  +                  |  49        |
      Leukemia Mononuclear                 |       X  X                                      X     X                  |          8 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +     +  +  A  +        +  +     +  +  +                  |  48        |
      Leukemia Mononuclear                 |                                                 X                        |          2 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +     +  +  +  +        +  +     +  +  +                  |  50        |
      Leukemia Mononuclear                 |       X  X                                      X  X  X                  |         14 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  13                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 4| 7| 7| 6| 1| 4| 7| 4| 1| 6| 1| 7| 6| 6| 4| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 1| 4| 6| 3| 3| 6| 8| 6| 3| 6| 8| 1| 8| 3| 8| 2| 6| 3| 3| 3| 1| 1|             
                                           | 4| 4| 4| 3| 4| 4| 4| 4| 8| 3| 4| 4| 4| 3| 1| 3| 4| 6| 8| 4| 5| 5| 4| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.5%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    61LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  M  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | M  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +     +  +  +        +        +     M  +  +     +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +     +  +  +        M        +     +  +  +     +  +  +  +  A|             
      Leukemia Mononuclear                 |                                                       X                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  A     +  +  +        +        +     +  +  +     M  +  +  +  A|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
      Carcinoma, Metastatic, Ovary         |                                                                          |             
      Hepatocellular Adenoma               |       X                                                                  |             
      Leukemia Mononuclear                 |             X        X  X                 X        X  X              X  X|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Carcinoma, Metastatic, Ovary         |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                             X        X  X                  |             
      Acinus, Adenoma                      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                    X  X                  |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                    X                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                             X        X  X              X  X|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                    X  X                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +     +  +  +        +        M     +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                    X  X                  |             
      Pheochromocytoma Benign              |       X                                                                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  M  +  M     +  +  +        +        M     +  +  +     +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  M  +  +|             
      Pars Distalis, Adenoma               | X     X           X              X              X     X     X  X     X   |             
      Pars Distalis, Adenoma, Multiple     |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 4| 7| 7| 6| 1| 4| 7| 4| 1| 6| 1| 7| 6| 6| 4| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 1| 4| 6| 3| 3| 6| 8| 6| 3| 6| 8| 1| 8| 3| 8| 2| 6| 3| 3| 3| 1| 1|             
                                           | 4| 4| 4| 3| 4| 4| 4| 4| 8| 3| 4| 4| 4| 3| 1| 3| 4| 6| 8| 4| 5| 5| 4| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.5%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    61LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Leukemia Mononuclear  |                                                       X              X   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
      C-Cell, Adenoma                      |                                  X        X                 X            |             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +     +  +  +        +        +     +  M  +     +  +  +  +  +|             
      Adenoma                              |                                  X                                       |             
      Leukemia Mononuclear                 |                                                       X                  |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
      Granulosa Cell Tumor Benign          |                                  X                                       |             
      Leukemia Mononuclear                 |                                                       X                  |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
      Polyp Stromal                        |                   X                                X        X           X|             
      Polyp Stromal, Multiple              |                                                                          |             
      Sarcoma Stromal                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  A|             
      Leukemia Mononuclear                 |                                                    X  X              X   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
      Mediastinal, Carcinoma, Metastatic,  |                                                                          |             
           Ovary                           |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |                                                    X  X              X   |             
      Pancreatic, Leukemia Mononuclear     |                                                    X                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                             X        X  X              X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                                      X  X              X   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  A|             
      Leukemia Mononuclear                 |             X     X  X  X                 X           X              X   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +     +  +  M        +        +     +  +  +     +  +  M  +  +|             
      Leukemia Mononuclear                 |             X                                      X  X              X  X|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  +  +     +  +  +        +        +     M  +  +     +  +  M  +  +|             
      Fibroadenoma                         |    X     X                                         X                     |             
      Fibroadenoma, Multiple               |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 4| 7| 7| 6| 1| 4| 7| 4| 1| 6| 1| 7| 6| 6| 4| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 1| 4| 6| 3| 3| 6| 8| 6| 3| 6| 8| 1| 8| 3| 8| 2| 6| 3| 3| 3| 1| 1|             
                                           | 4| 4| 4| 3| 4| 4| 4| 4| 8| 3| 4| 4| 4| 3| 1| 3| 4| 6| 8| 4| 5| 5| 4| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.5%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    61LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Carcinoma Adenosquamous              |                                                                          |             
      Keratoacanthoma                      |                                                                          |             
      Subcutaneous Tissue, Fibroma         |             X           X                                                |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Carcinoma Adenosquamous, Metastatic, |                                                                          |             
           Skin                            |                                                                          |             
      Leukemia Mononuclear                 |             X        X  X                 X        X  X              X  X|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |    +                                                                     |             
                                            __________________________________________________________________________|             
   Eye                                     |    +     +        +  +                    I        +                     |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |          +        +  +                             +                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                             X        X  X                 X|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +     +  +  +        +        +     +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |             X     X  X  X                 X        X  X              X  X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 1| 4| 7| 7| 7| 1| 1| 7| 6| 7| 4| 4| 7| 6| 7| 7| 7| 6| 5| 7| 7| 7| 1| 4|             
                             DAY ON TEST   | 3| 8| 6| 3| 1| 3| 8| 8| 3| 7| 3| 6| 6| 3| 6| 3| 3| 3| 8| 4| 3| 3| 3| 8| 7|             
                                           | 5| 3| 4| 4| 0| 5| 2| 3| 5| 2| 5| 4| 4| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 2| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.5%                                   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    61LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +        +  +  +        +  +  +        +  +  +  +  +  +  +  M  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +        +  +  +        +  +  +        +  +  +  +  +  +  +  M  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Liver                                   | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
      Carcinoma, Metastatic, Ovary         |                                                                          |             
      Hepatocellular Adenoma               |                                                                          |             
      Leukemia Mononuclear                 |             X              X                                   X  X      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                         +|             
      Carcinoma, Metastatic, Ovary         |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |             X                                                            |             
      Acinus, Adenoma                      |                X                                                         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +        +  +  +        +  +  +        +  +  +  +  +  M  +  +  +  +     M|             
      Leukemia Mononuclear                 |             X                                                            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |             X              X                                             |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                            X                                   X         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +        +  +  +        +  +  +        +  +  +  +  +  +  I  +  +  +     +|             
      Leukemia Mononuclear                 |                            X                                   X         |             
      Pheochromocytoma Benign              |                                                 X              X         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +        +  +  +        +  +  +        +  +  +  M  +  +  M  M  M  +     +|             
      Adenoma                              |                                                       X                  |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
      Pars Distalis, Adenoma               | X              X        X  X  X        X     X  X  X  X     X  X  X     X|             
      Pars Distalis, Adenoma, Multiple     |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 1| 4| 7| 7| 7| 1| 1| 7| 6| 7| 4| 4| 7| 6| 7| 7| 7| 6| 5| 7| 7| 7| 1| 4|             
                             DAY ON TEST   | 3| 8| 6| 3| 1| 3| 8| 8| 3| 7| 3| 6| 6| 3| 6| 3| 3| 3| 8| 4| 3| 3| 3| 8| 7|             
                                           | 5| 3| 4| 4| 0| 5| 2| 3| 5| 2| 5| 4| 4| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 2| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.5%                                   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    61LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Leukemia Mononuclear  |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
      C-Cell, Adenoma                      |                                                    X                     |             
      Follicular Cell, Adenoma             |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +        +  +  +        +  +  +        M  +  +  +  +  +  +  +  +  +     +|             
      Adenoma                              |          X  X                                                     X      |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
      Carcinoma                            |                                                                          |             
      Granulosa Cell Tumor Benign          |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
      Polyp Stromal                        |                                                                   X      |             
      Polyp Stromal, Multiple              |                                                                          |             
      Sarcoma Stromal                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
      Mediastinal, Carcinoma, Metastatic,  |                                                                          |             
           Ovary                           |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |             X              X                                             |             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +        +  +  +        +  +  +        +  +  +  +  M  M  +  M  +  +     +|             
      Leukemia Mononuclear                 |             X                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |             X              X                                             |             
                                            __________________________________________________________________________|             
   Spleen                                  | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |             X              X                                   X  X      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +        M  +  +        +  +  +        +  +  +  +  +  +  +  M  +  +     +|             
      Leukemia Mononuclear                 |             X              X                                             |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M        +  M  +        M  +  +        +  M  M  M  +  +  +  +  +  M     +|             
      Fibroadenoma                         |                            X  X        X           X        X            |             
      Fibroadenoma, Multiple               |                X                                                         |             
                                            __________________________________________________________________________|             
   Skin                                    | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 1| 4| 7| 7| 7| 1| 1| 7| 6| 7| 4| 4| 7| 6| 7| 7| 7| 6| 5| 7| 7| 7| 1| 4|             
                             DAY ON TEST   | 3| 8| 6| 3| 1| 3| 8| 8| 3| 7| 3| 6| 6| 3| 6| 3| 3| 3| 8| 4| 3| 3| 3| 8| 7|             
                                           | 5| 3| 4| 4| 0| 5| 2| 3| 5| 2| 5| 4| 4| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 2| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.5%                                   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    61LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Carcinoma Adenosquamous              |                                                          X               |             
      Keratoacanthoma                      |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                              +                           |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
      Alveolar/Bronchiolar Adenoma         |                                                          X               |             
      Carcinoma Adenosquamous, Metastatic, |                                                                          |             
           Skin                            |                                                          X               |             
      Leukemia Mononuclear                 |             X              X                                   X         |             
                                            __________________________________________________________________________|             
   Nose                                    | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                         +|             
                                            __________________________________________________________________________|             
   Eye                                     |                                              +                    +      |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |             X                                                            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     M|             
      Leukemia Mononuclear                 |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +        +  +  +        +  +  +        +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |             X              X                                   X  X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 6| 7| 7| 4| 7| 1| 7| 7| 1| 6| 6| 7| 7| 4| 7| 1|              |            |
                             DAY ON TEST   | 3| 6| 3| 3| 1| 3| 3| 6| 1| 8| 3| 1| 8| 6| 1| 3| 3| 6| 3| 8|              |            |
                                           | 4| 4| 4| 1| 9| 4| 4| 4| 0| 2| 4| 3| 3| 6| 2| 4| 4| 4| 4| 2|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|              |     A      |
    0.5%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |     L      |
    61LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +     +  +  +  +  +     +     M  +     +  +  +  +     +                  |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | M     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +     +  +  +  +  +     +     +  +     +  M  +  +     +                  |  47        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +     +  +  +  +  +     +     +  +     +  +  +  M     +                  |  46        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  50        |
      Carcinoma, Metastatic, Ovary         |                                        X                                 |          1 |
      Hepatocellular Adenoma               |                                                                          |          1 |
      Leukemia Mononuclear                 |          X                                X                              |         14 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                   +                    +        +                        |   4        |
      Carcinoma, Metastatic, Ovary         |                                        X                                 |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  50        |
      Leukemia Mononuclear                 |                                                                          |          5 |
      Acinus, Adenoma                      |                                              X                           |          2 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  50        |
      Leukemia Mononuclear                 |          X                                                               |          3 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  48        |
      Leukemia Mononuclear                 |          X                                X                              |          4 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  50        |
      Leukemia Mononuclear                 |          X                                X                              |          4 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  50        |
      Leukemia Mononuclear                 |          X                                X                              |         10 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +     +  +  +  +  +     +     +  +     +  +  +  M     +                  |  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +     +  +  +  +  +     +     +  +     +  +  +  M     +                  |  49        |
      Leukemia Mononuclear                 |                                           X                              |          5 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +     +  +  +  +  +     +     +  +     +  M  +  M     +                  |  46        |
      Leukemia Mononuclear                 |                                                                          |          4 |
      Pheochromocytoma Benign              |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  20                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 6| 7| 7| 4| 7| 1| 7| 7| 1| 6| 6| 7| 7| 4| 7| 1|              |            |
                             DAY ON TEST   | 3| 6| 3| 3| 1| 3| 3| 6| 1| 8| 3| 1| 8| 6| 1| 3| 3| 6| 3| 8|              |            |
                                           | 4| 4| 4| 1| 9| 4| 4| 4| 0| 2| 4| 3| 3| 6| 2| 4| 4| 4| 4| 2|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|              |     A      |
    0.5%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |     L      |
    61LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +     +  +  +  M  +     +     +  +     +  M  +  M     +                  |  39        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +     +  +  +  +  +     +     +  +     +  +  M  +     +                  |  48        |
      Pars Distalis, Adenoma               | X     X  X     X              X  X              X     X                  |         31 |
      Pars Distalis, Adenoma, Multiple     |             X                          X                                 |          4 |
      Pars Distalis, Leukemia Mononuclear  |                                           X                              |          3 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      C-Cell, Adenoma                      |             X                             X     X                        |          7 |
      Follicular Cell, Adenoma             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +     +  +  +  +  +     +     M  +     +  +  +  +     +                  |  47        |
      Adenoma                              |                         X                                                |          5 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +     +  +  +  +  +     +     M  +     +  +  +  +     +                  |  49        |
      Carcinoma                            |                                        X                                 |          1 |
      Granulosa Cell Tumor Benign          |                                                                          |          1 |
      Leukemia Mononuclear                 |          X                                X                              |          3 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  50        |
      Polyp Stromal                        |                                              X  X                        |          7 |
      Polyp Stromal, Multiple              |       X                                                                  |          1 |
      Sarcoma Stromal                      |                X                                                         |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  49        |
      Leukemia Mononuclear                 |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  50        |
      Mediastinal, Carcinoma, Metastatic,  |                                                                          |            |
           Ovary                           |                                        X                                 |          1 |
      Mediastinal, Leukemia Mononuclear    |          X                                                               |          6 |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M     +  +  +  +  +     M     +  +     +  +  +  +     +                  |  45        |
      Leukemia Mononuclear                 |          X                                X                              |          8 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  50        |
      Leukemia Mononuclear                 |          X                                X                              |          8 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  21                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 6| 7| 7| 4| 7| 1| 7| 7| 1| 6| 6| 7| 7| 4| 7| 1|              |            |
                             DAY ON TEST   | 3| 6| 3| 3| 1| 3| 3| 6| 1| 8| 3| 1| 8| 6| 1| 3| 3| 6| 3| 8|              |            |
                                           | 4| 4| 4| 1| 9| 4| 4| 4| 0| 2| 4| 3| 3| 6| 2| 4| 4| 4| 4| 2|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|              |     A      |
    0.5%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |     L      |
    61LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  49        |
      Leukemia Mononuclear                 |          X                                X                              |         13 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +     +  +  M  +  +     +     M  +     +  M  M  +     +                  |  42        |
      Leukemia Mononuclear                 |          X                                                               |          8 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +     +  M  +  +  +     +     +  +     +  +  +  M     M                  |  37        |
      Fibroadenoma                         | X           X     X     X     X        X  X  X                           |         16 |
      Fibroadenoma, Multiple               |                X                 X                                       |          3 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  50        |
      Carcinoma Adenosquamous              |                                                                          |          1 |
      Keratoacanthoma                      |          X                                                               |          1 |
      Subcutaneous Tissue, Fibroma         |                                                                          |          3 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  50        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          1 |
      Carcinoma Adenosquamous, Metastatic, |                                                                          |            |
           Skin                            |                                                                          |          1 |
      Leukemia Mononuclear                 |          X                                X                              |         13 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +     +  +  +  +  +     +     +  +     +  +  M  +     +                  |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |             +                                                            |   3        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                           +                              |   8        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   4        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  22                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 6| 7| 7| 4| 7| 1| 7| 7| 1| 6| 6| 7| 7| 4| 7| 1|              |            |
                             DAY ON TEST   | 3| 6| 3| 3| 1| 3| 3| 6| 1| 8| 3| 1| 8| 6| 1| 3| 3| 6| 3| 8|              |            |
                                           | 4| 4| 4| 1| 9| 4| 4| 4| 0| 2| 4| 3| 3| 6| 2| 4| 4| 4| 4| 2|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|              |     A      |
    0.5%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |     L      |
    61LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |          X                                X                              |          8 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +     +  +  +  +  +     +     +  +     +  M  +  +     +                  |  48        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +     +  +  +  +  +     +     +  +     +  +  +  +     +                  |  50        |
      Leukemia Mononuclear                 |          X                                X                              |         15 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  23                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 4| 7| 7| 6| 5| 1| 7| 7| 7| 1| 7| 7| 7| 4| 7| 6| 1| 1| 7| 4| 5|             
                             DAY ON TEST   | 3| 1| 7| 4| 6| 3| 3| 5| 3| 8| 3| 3| 3| 8| 3| 3| 3| 6| 3| 4| 8| 8| 3| 6| 5|             
                                           | 1| 6| 2| 5| 4| 4| 4| 0| 1| 2| 4| 4| 4| 2| 4| 1| 1| 4| 1| 3| 2| 2| 1| 4| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    1.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    61HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  A  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
      Leukemia Mononuclear                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +     +  +  M  +     +  +  M     +  +  +     +  +        +     +|             
      Leukemia Mononuclear                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +     +  +  +  +     +  M  +     +  +  +     +  +        +     +|             
      Leukemia Mononuclear                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  A  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
      Leukemia Mononuclear                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
      Leukemia Mononuclear                 |                         X                                                |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
      Leukemia Mononuclear                 |          X              X                                X        X      |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +        +                                                      |             
      Leukemia Mononuclear                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +     +  +  M  +     +  +  +     +  +  +     +  +        +     +|             
      Leukemia Mononuclear                 |          X              X                                                |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
      Leukemia Mononuclear                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
      Leukemia Mononuclear                 |          X                                                               |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
      Leukemia Mononuclear                 |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
      Leukemia Mononuclear                 |          X              X                                                |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |                         X                                                |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
      Leukemia Mononuclear                 |          X              X                                                |             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  M     +  +  M  +     +  +  +     +  +  +     +  +        +     +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M     M  +  +  +     +  +  +     +  +  +     +  M        +     M|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 4| 7| 7| 6| 5| 1| 7| 7| 7| 1| 7| 7| 7| 4| 7| 6| 1| 1| 7| 4| 5|             
                             DAY ON TEST   | 3| 1| 7| 4| 6| 3| 3| 5| 3| 8| 3| 3| 3| 8| 3| 3| 3| 6| 3| 4| 8| 8| 3| 6| 5|             
                                           | 1| 6| 2| 5| 4| 4| 4| 0| 1| 2| 4| 4| 4| 2| 4| 1| 1| 4| 1| 3| 2| 2| 1| 4| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    1.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    61HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
      Pars Distalis, Adenoma               |    X           X     X           X  X        X        X  X              X|             
      Pars Distalis, Adenoma, Multiple     |                               X                                          |             
      Pars Distalis, Leukemia Mononuclear  |          X              X                                                |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
      Bilateral, C-Cell, Adenoma           |                                              X                           |             
      C-Cell, Adenoma                      |       X                 X        X                                       |             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +     +  +  M  +     M  +  M     +  +  +     +  +        +     +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                           X                              |             
      Leukemia Mononuclear                 |                         X                                                |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
      Leukemia Mononuclear                 |          X              X                                                |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
      Leukemia Mononuclear                 |          X                                                               |             
      Polyp Stromal                        | X              X  X                                   X  X               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  M        +     +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
      Axillary, Leukemia Mononuclear       |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |          X                                                               |             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +     +  +  +  M     +  +  +     +  +  +     +  +        +     +|             
      Leukemia Mononuclear                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
      Leukemia Mononuclear                 |          X              X                                         X      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
      Leukemia Mononuclear                 |          X              X                                X        X      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +     +  M  M  +     M  +  +     +  +  +     +  +        +     +|             
      Leukemia Mononuclear                 |          X              X                                                |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
      Adenoma                              |                                                       X                  |             
      Fibroadenoma                         | X     X           X  X        X     X     X                              |             
      Fibroadenoma, Multiple               |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 4| 7| 7| 6| 5| 1| 7| 7| 7| 1| 7| 7| 7| 4| 7| 6| 1| 1| 7| 4| 5|             
                             DAY ON TEST   | 3| 1| 7| 4| 6| 3| 3| 5| 3| 8| 3| 3| 3| 8| 3| 3| 3| 6| 3| 4| 8| 8| 3| 6| 5|             
                                           | 1| 6| 2| 5| 4| 4| 4| 0| 1| 2| 4| 4| 4| 2| 4| 1| 1| 4| 1| 3| 2| 2| 1| 4| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    1.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    61HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
      Leukemia Mononuclear                 |                         X                                                |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |          +                                                               |             
      Leukemia Mononuclear                 |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
      Leukemia Mononuclear                 |          X              X                                                |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                         +                                                |             
      Leukemia Mononuclear                 |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Leukemia Mononuclear                 |          X              X                                                |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +     +  +  +  +     +  +  +     +  M  +     +  +        +     +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
      Leukemia Mononuclear                 |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                 +                       +|             
      Squamous Cell Papilloma              |                                                 X                        |             
                                            __________________________________________________________________________|             
   Eye                                     | +     +  I     +     +              +     +                              |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +     +        +     +              +     +                              |             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
      Leukemia Mononuclear                 |          X              X                                                |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
      Leukemia Mononuclear                 |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +        +     +|             
      Leukemia Mononuclear                 |          X              X                                X        X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 4| 4| 6| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 1| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 2| 6| 6| 8| 3| 3| 3| 3| 9| 3| 2| 6| 2| 1| 3| 2| 8| 2| 1|             
                                           | 1| 1| 1| 1| 2| 1| 2| 4| 4| 6| 1| 1| 1| 1| 2| 0| 9| 4| 9| 0| 0| 9| 3| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    1.0%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    61HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  M  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                   X        X                                             |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +                 +                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Squamous Cell Papilloma              |                                                                         X|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                   X        X                                             |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Adenoma                              |             X                                                            |             
      Leukemia Mononuclear                 |                            X                                             |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  M        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                            X                                             |             
      Pheochromocytoma Benign              |                                     X  X                                 |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Adenoma                              |                            X                                             |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 4| 4| 6| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 1| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 2| 6| 6| 8| 3| 3| 3| 3| 9| 3| 2| 6| 2| 1| 3| 2| 8| 2| 1|             
                                           | 1| 1| 1| 1| 2| 1| 2| 4| 4| 6| 1| 1| 1| 1| 2| 0| 9| 4| 9| 0| 0| 9| 3| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    1.0%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    61HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  M  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Pars Distalis, Adenoma               | X     X        X           X  X  X  X     X  X           X  X  X        X|             
      Pars Distalis, Adenoma, Multiple     |                                                                          |             
      Pars Distalis, Leukemia Mononuclear  |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Bilateral, C-Cell, Adenoma           |                                                                          |             
      C-Cell, Adenoma                      |                            X     X  X                                    |             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  M  +  +  +        +  +  +  M  +  +  +  +     +  +  +  +     +  M|             
      Adenoma                              |                               X                             X            |             
      Carcinoma                            |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                   X                                                      |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Polyp Stromal                        |             X                    X           X                 X         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Axillary, Leukemia Mononuclear       |                   X                                                      |             
      Mediastinal, Leukemia Mononuclear    |                   X        X                                             |             
      Pancreatic, Leukemia Mononuclear     |                   X        X                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +        +  +  +  M  +  +  +  +     +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                   X        X                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                   X        X                                             |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                   X        X                                             |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +        +  +  +  +  +  +  +  +     M  +  +  +     +  +|             
      Leukemia Mononuclear                 |                   X        X                                             |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  M  +  +        +  +  +  +  +  +  +  M     +  +  +  +     +  +|             
      Adenoma                              |                                                                          |             
      Fibroadenoma                         | X        X     X                       X              X     X  X         |             
      Fibroadenoma, Multiple               |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 4| 4| 6| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 1| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 2| 6| 6| 8| 3| 3| 3| 3| 9| 3| 2| 6| 2| 1| 3| 2| 8| 2| 1|             
                                           | 1| 1| 1| 1| 2| 1| 2| 4| 4| 6| 1| 1| 1| 1| 2| 0| 9| 4| 9| 0| 0| 9| 3| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    1.0%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    61HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Subcutaneous Tissue, Fibroma         |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                          +               |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                         X|             
      Leukemia Mononuclear                 |                   X        X                                             |             
                                            __________________________________________________________________________|             
   Nose                                    | +  M  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                           +                              |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |          +                                      +        +           +  +|             
                                            __________________________________________________________________________|             
   Harderian Gland                         |          +                                      +        +           +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                           +                              |             
      Carcinoma                            |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                            X                                             |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                   X        X                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 7| 7| 7| 7| 7| 1| 7| 6| 4| 7| 4| 4| 1| 7| 4| 1| 1| 6| 4|              |            |
                             DAY ON TEST   | 8| 2| 2| 2| 2| 2| 8| 2| 3| 9| 2| 6| 6| 8| 2| 6| 8| 8| 5| 6|              |            |
                                           | 2| 9| 9| 9| 9| 9| 2| 9| 2| 7| 9| 4| 4| 2| 9| 4| 3| 2| 1| 4|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|              |     A      |
    1.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |     L      |
    61HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +  +  +  +  +     +  +  +  +           +           +                  |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +  +  +  +  +     +  +  +  +           +           +                  |  47        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +  +  +  +  +     +  +  +  +           +           +                  |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +  +  +  +  +     +  +  +  +           +           +                  |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +  +  +  +  +     +  +  +  +           +           +                  |  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
      Leukemia Mononuclear                 |          X           X     X  X                                          |         10 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +           +                                                         |   6        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +  +  +  +  +     +  +  +  +           +           +                  |  49        |
      Leukemia Mononuclear                 |          X                                                               |          3 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
      Leukemia Mononuclear                 |          X           X     X                                             |          7 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
      Adenoma                              |                                                                          |          1 |
      Leukemia Mononuclear                 |                      X     X                                             |          4 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    +  +  +  +  +     +  +  +  +           +           +                  |  49        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  30                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 7| 7| 7| 7| 7| 1| 7| 6| 4| 7| 4| 4| 1| 7| 4| 1| 1| 6| 4|              |            |
                             DAY ON TEST   | 8| 2| 2| 2| 2| 2| 8| 2| 3| 9| 2| 6| 6| 8| 2| 6| 8| 8| 5| 6|              |            |
                                           | 2| 9| 9| 9| 9| 9| 2| 9| 2| 7| 9| 4| 4| 2| 9| 4| 3| 2| 1| 4|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|              |     A      |
    1.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |     L      |
    61HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |                      X     X                                             |          5 |
      Pheochromocytoma Benign              |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +  +  +  +  +     +  +  +  +           +           +                  |  48        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    M  +  +  +  +     +  +  +  +           +           +                  |  45        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +  +  +  +  +     +  +  +  +           +           +                  |  49        |
      Pars Distalis, Adenoma               |       X     X  X     X  X     X                       X                  |         29 |
      Pars Distalis, Adenoma, Multiple     |                                                                          |          1 |
      Pars Distalis, Leukemia Mononuclear  |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
      Bilateral, C-Cell, Adenoma           |                                                                          |          1 |
      C-Cell, Adenoma                      |    X                                                                     |          7 |
      Follicular Cell, Adenoma             |                      X                                                   |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |    +  +  +  +  +     +  +  +  +           +           +                  |  44        |
      Adenoma                              |                                                                          |          2 |
      Carcinoma                            |             X                                                            |          2 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Ovary                                   |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
      Leukemia Mononuclear                 |          X                 X                                             |          5 |
                                            __________________________________________________________________________|____________|
   Uterus                                  |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Polyp Stromal                        |    X                    X     X                                          |         12 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +  +  +  +  +     +  +  +  +           +           +                  |  49        |
      Leukemia Mononuclear                 |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
      Axillary, Leukemia Mononuclear       |                                                                          |          1 |
      Mediastinal, Leukemia Mononuclear    |                      X                                                   |          4 |
      Pancreatic, Leukemia Mononuclear     |                      X                                                   |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |    +  +  +  +  +     +  +  +  +           +           +                  |  48        |
      Leukemia Mononuclear                 |          X           X                                                   |          5 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +  +  +  +  +     +  M  +  +           +           +                  |  49        |
      Leukemia Mononuclear                 |          X           X     X                                             |          8 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  31                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 7| 7| 7| 7| 7| 1| 7| 6| 4| 7| 4| 4| 1| 7| 4| 1| 1| 6| 4|              |            |
                             DAY ON TEST   | 8| 2| 2| 2| 2| 2| 8| 2| 3| 9| 2| 6| 6| 8| 2| 6| 8| 8| 5| 6|              |            |
                                           | 2| 9| 9| 9| 9| 9| 2| 9| 2| 7| 9| 4| 4| 2| 9| 4| 3| 2| 1| 4|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|              |     A      |
    1.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |     L      |
    61HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
      Leukemia Mononuclear                 |          X           X     X  X                                          |         10 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |    M  +  +  +  +     +  M  +  +           +           +                  |  43        |
      Leukemia Mononuclear                 |          X           X                                                   |          6 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +  +  +  M  +     +  +  +  +           +           +                  |  47        |
      Adenoma                              |                                           X                              |          2 |
      Fibroadenoma                         |                X              X                                          |         16 |
      Fibroadenoma, Multiple               |                                                                          |          2 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    |    +  +  +  M  +     +  +  +  +           +           +                  |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   2        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
      Alveolar/Bronchiolar Adenoma         |                               X                                          |          2 |
      Leukemia Mononuclear                 |          X           X     X  X                                          |          8 |
                                            __________________________________________________________________________|____________|
   Nose                                    |    +  +  +  +  +     +  +  +  +           +           +                  |  48        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   3        |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Eye                                     |          +  +  +        +                 +           +                  |  17        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |          +  +                             +           +                  |  15        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  32                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 7| 7| 7| 7| 7| 1| 7| 6| 4| 7| 4| 4| 1| 7| 4| 1| 1| 6| 4|              |            |
                             DAY ON TEST   | 8| 2| 2| 2| 2| 2| 8| 2| 3| 9| 2| 6| 6| 8| 2| 6| 8| 8| 5| 6|              |            |
                                           | 2| 9| 9| 9| 9| 9| 2| 9| 2| 7| 9| 4| 4| 2| 9| 4| 3| 2| 1| 4|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|              |     A      |
    1.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |     L      |
    61HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Adenoma                              |                                           X                              |          1 |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
      Carcinoma                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
      Leukemia Mononuclear                 |                      X                                                   |          4 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         |    +  +  +  +  +     +  +  +  +           +           +                  |  50        |
      Leukemia Mononuclear                 |          X           X     X  X                                          |         10 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  33                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 1| 7| 7| 6| 6| 5| 7| 7| 6| 4| 6| 1| 1| 7| 7| 1| 5| 7| 6| 6| 4|             
                             DAY ON TEST   | 3| 3| 3| 7| 7| 3| 0| 7| 3| 9| 3| 2| 6| 7| 5| 7| 7| 3| 3| 7| 8| 1| 8| 6| 7|             
                                           | 1| 1| 2| 0| 5| 2| 7| 3| 7| 8| 1| 4| 5| 0| 5| 5| 5| 1| 1| 5| 7| 0| 9| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    D 61 UM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +        +  +  +  +  +  +  +  +     +        +  +     M  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +        +  +  +  +  +  +  +  A     +        +  +     A  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +        +  +  +  +  +  +  +  A     +        +  +     A  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +        +  +  +  +  +  +  +  A     +        +  +     A  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +        +  +  +  +  +  +  +  A     +        +  +     A  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +        +  +  +  +  +  +  +  A     +        +  +     A  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +        +  +  +  +  +  +  +  A     +        +  +     A  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +        +  +  +  +  +  +  +  A     +        +  +     A  +  +  +   |             
      Leukemia Mononuclear                 |                         X                                                |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +        +  +  +  +  +  +  +  A     +        +  +     A  +  +  +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
      Fibrosarcoma, Metastatic, Skin       |                                                                          |             
      Hepatocellular Adenoma               |                                                                          |             
      Leukemia Mononuclear                 |                   X  X  X  X              X                 X     X  X   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +                                                   |             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
      Leukemia Mononuclear                 |                            X                                             |             
      Mesothelioma Malignant               |                                                                          |             
      Acinus, Adenoma                      |                                                                          |             
      Acinus, Adenoma, Multiple            |                X                                                         |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
      Palate, Squamous Cell Papilloma      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
      Leukemia Mononuclear                 |                                                             X            |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +        +  +  +  +  +  +  +  A     +        +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
      Leukemia Mononuclear                 |                   X        X                                X        X   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
      Carcinoma                            |                                                                          |             
      Leukemia Mononuclear                 |                   X        X                                X     X      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
      Leukemia Mononuclear                 |                   X     X  X                                X     X      |             
      Pheochromocytoma Malignant           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 1| 7| 7| 6| 6| 5| 7| 7| 6| 4| 6| 1| 1| 7| 7| 1| 5| 7| 6| 6| 4|             
                             DAY ON TEST   | 3| 3| 3| 7| 7| 3| 0| 7| 3| 9| 3| 2| 6| 7| 5| 7| 7| 3| 3| 7| 8| 1| 8| 6| 7|             
                                           | 1| 1| 2| 0| 5| 2| 7| 3| 7| 8| 1| 4| 5| 0| 5| 5| 5| 1| 1| 5| 7| 0| 9| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    D 61 UM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pheochromocytoma Benign              |                X     X                    X                    X         |             
      Bilateral, Pheochromocytoma Benign   |    X  X           X              X                    X                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +        +  +  +  +  +  +  +  +     +        +  +     A  +  +  +   |             
      Adenoma                              |                                                    X                     |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                   X      |             
      Pars Distalis, Adenoma               |    X  X                 X  X  X     X              X           X         |             
      Pars Distalis, Leukemia Mononuclear  |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +        +  +  +  +  +  +  +  A     +        +  +     +  +  +  +   |             
      Leukemia Mononuclear                 |                                                             X            |             
      C-Cell, Adenoma                      |                                                                          |             
      C-Cell, Adenoma, Multiple            |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +        +  +  +  +  +  +  +  M     +        +  +     +  +  +  +   |             
      Mesothelioma Malignant               |    X                                                                     |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +        +  +  +  +  +  +  +  M     +        +  +     +  +  +  +   |             
      Adenoma                              |       X                          X                                       |             
      Carcinoma                            |                                                                          |             
      Bilateral, Adenoma                   |                                                       X                  |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +        +  +  +  +  +  +  +  M     +        +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +        +  +  +  +  +  +  +  M     +        +  +     +  +  +  +   |             
      Leukemia Mononuclear                 |                                                             X            |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
      Leukemia Mononuclear                 |                                                             X            |             
      Bilateral, Interstitial Cell, Adenoma| X  X  X        X     X        X           X           X     X  X  X  X   |             
      Interstitial Cell, Adenoma           |                   X     X  X     X  X              X                     |             
      Tunic, Mesothelioma Malignant        |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                            +                                             |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +        +  +  +  +  +  +  +  +     +        +  +     A  +  +  +   |             
      Leukemia Mononuclear                 |                                                                   X      |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
      Lumbar, Leukemia Mononuclear         |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |                         X                                         X  X   |             
      Pancreatic, Leukemia Mononuclear     |                                                                      X   |             
      Renal, Leukemia Mononuclear          |                                                                   X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +        +  +  +  +  +  +  +  M     +        +  +     +  M  +  +   |             
      Leukemia Mononuclear                 |                            X                                X     X  X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 1| 7| 7| 6| 6| 5| 7| 7| 6| 4| 6| 1| 1| 7| 7| 1| 5| 7| 6| 6| 4|             
                             DAY ON TEST   | 3| 3| 3| 7| 7| 3| 0| 7| 3| 9| 3| 2| 6| 7| 5| 7| 7| 3| 3| 7| 8| 1| 8| 6| 7|             
                                           | 1| 1| 2| 0| 5| 2| 7| 3| 7| 8| 1| 4| 5| 0| 5| 5| 5| 1| 1| 5| 7| 0| 9| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    D 61 UM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
      Leukemia Mononuclear                 |                            X                                X     X  X   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
      Leukemia Mononuclear                 |                   X  X  X  X              X                 X     X  X   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
      Leukemia Mononuclear                 |                   X        X                                X     X  X   |             
      Thymoma Benign                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  M        +  M  +  +  M  +  M  +     +        +  +     M  +  M  +   |             
      Adenoma                              |                                                                X         |             
      Fibroadenoma                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
      Basal Cell Carcinoma                 |                                  X                                       |             
      Leukemia Mononuclear                 |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
      Leukemia Mononuclear                 |                            X                                X     X      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Carcinoma, Metastatic, Adrenal Gland |                                                                          |             
      Carcinoma, Metastatic, Preputial     |                                                                          |             
          Gland                            |                                                                          |             
      Leukemia Mononuclear                 |                   X  X  X  X              X                       X  X   |             
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |             
          Primary Site                     |                            X                                             |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
      Leukemia Mononuclear                 |                                                             X            |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                         +                                                |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                   +     +                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 1| 7| 7| 6| 6| 5| 7| 7| 6| 4| 6| 1| 1| 7| 7| 1| 5| 7| 6| 6| 4|             
                             DAY ON TEST   | 3| 3| 3| 7| 7| 3| 0| 7| 3| 9| 3| 2| 6| 7| 5| 7| 7| 3| 3| 7| 8| 1| 8| 6| 7|             
                                           | 1| 1| 2| 0| 5| 2| 7| 3| 7| 8| 1| 4| 5| 0| 5| 5| 5| 1| 1| 5| 7| 0| 9| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    D 61 UM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
      Leukemia Mononuclear                 |                   X  X  X  X                                X     X  X   |             
      Renal Tubule, Adenoma                |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +        +  +  +  +  +  +  +  M     +        +  +     +  +  +  +   |             
      Leukemia Mononuclear                 |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +        +  +  +  +  +  +  +  +     +        +  +     +  +  +  +   |             
      Leukemia Mononuclear                 |                   X  X  X  X              X                 X     X  X   |             
      Mesothelioma Malignant               |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 1| 6| 1| 6| 4| 6| 6| 2| 7| 7| 7| 4| 7| 4| 7| 6| 1| 6| 7| 4| 4| 4| 1|             
                             DAY ON TEST   | 3| 2| 7| 1| 7| 5| 7| 3| 2| 8| 3| 3| 3| 7| 2| 7| 1| 5| 7| 1| 1| 7| 7| 7| 7|             
                                           | 1| 5| 5| 0| 6| 8| 0| 7| 5| 8| 1| 2| 2| 0| 1| 0| 0| 1| 6| 9| 3| 0| 0| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATE                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    D 61 UM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +     +     +     +  +  +  +  +  +     +     +  +     +  A            |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +     +     +     +  +  +  +  +  +     +     +  +     +  A            |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +     +     +     +  +  +  +  +  +     +     +  +     +  A            |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +     +     +     +  +  +  +  +  +     +     +  +     +  A            |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +     +     M     +  +  +  +  +  +     +     +  +     +  A            |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +     +     M     +  +  +  +  +  +     +     +  +     +  A            |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
      Fibrosarcoma, Metastatic, Skin       |                                                                          |             
      Hepatocellular Adenoma               |                                     X                                    |             
      Leukemia Mononuclear                 | X  X     X                                X     X  X                     |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                    +                     |             
      Leukemia Mononuclear                 |                                                    X                     |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
      Leukemia Mononuclear                 |          X                                                               |             
      Mesothelioma Malignant               |                                                                          |             
      Acinus, Adenoma                      |                                                                          |             
      Acinus, Adenoma, Multiple            |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                         +                                                |             
      Palate, Squamous Cell Papilloma      |                         X                                                |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +     +     +     +  +  +  +  +  +     +     +  +     M  +            |             
      Leukemia Mononuclear                 |                                                 X                        |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
      Squamous Cell Papilloma              |          X                                                               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
      Leukemia Mononuclear                 |    X     X                                X     X  X                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
      Carcinoma                            |                                                             X            |             
      Leukemia Mononuclear                 |    X     X                                X     X  X                     |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
      Leukemia Mononuclear                 |    X     X                                X     X  X                     |             
      Pheochromocytoma Malignant           | X                    X                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 1| 6| 1| 6| 4| 6| 6| 2| 7| 7| 7| 4| 7| 4| 7| 6| 1| 6| 7| 4| 4| 4| 1|             
                             DAY ON TEST   | 3| 2| 7| 1| 7| 5| 7| 3| 2| 8| 3| 3| 3| 7| 2| 7| 1| 5| 7| 1| 1| 7| 7| 7| 7|             
                                           | 1| 5| 5| 0| 6| 8| 0| 7| 5| 8| 1| 2| 2| 0| 1| 0| 0| 1| 6| 9| 3| 0| 0| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATE                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    D 61 UM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pheochromocytoma Benign              | X                    X                          X  X        X            |             
      Bilateral, Pheochromocytoma Benign   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +     +     M     M  +  +  M  +  +     +     +  +     +  +            |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +     +     +     M  +  +  +  +  +     +     +  +     +  +            |             
      Leukemia Mononuclear                 |                                                 X  X                     |             
      Pars Distalis, Adenoma               | X        X                    X                 X                        |             
      Pars Distalis, Leukemia Mononuclear  |          X                                                               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
      Leukemia Mononuclear                 |                                                                          |             
      C-Cell, Adenoma                      |                      X              X                                    |             
      C-Cell, Adenoma, Multiple            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
      Adenoma                              |                               X  X                                       |             
      Carcinoma                            |                                                                          |             
      Bilateral, Adenoma                   |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +     +     +     +  M  +  +  +  +     +     +  +     +  +            |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +     +     +     +  M  +  +  +  +     +     +  +     +  +            |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
      Leukemia Mononuclear                 |                                                                          |             
      Bilateral, Interstitial Cell, Adenoma| X  X     X     X     X  X     X  X  X     X     X           X            |             
      Interstitial Cell, Adenoma           |                                                    X     X               |             
      Tunic, Mesothelioma Malignant        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
      Lumbar, Leukemia Mononuclear         |                                                    X                     |             
      Mediastinal, Leukemia Mononuclear    |    X     X                                X     X  X                     |             
      Pancreatic, Leukemia Mononuclear     |                                                 X  X                     |             
      Renal, Leukemia Mononuclear          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +     +     +     +  +  +  +  +  +     +     +  +     M  +            |             
      Leukemia Mononuclear                 |    X     X                                X     X  X                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 1| 6| 1| 6| 4| 6| 6| 2| 7| 7| 7| 4| 7| 4| 7| 6| 1| 6| 7| 4| 4| 4| 1|             
                             DAY ON TEST   | 3| 2| 7| 1| 7| 5| 7| 3| 2| 8| 3| 3| 3| 7| 2| 7| 1| 5| 7| 1| 1| 7| 7| 7| 7|             
                                           | 1| 5| 5| 0| 6| 8| 0| 7| 5| 8| 1| 2| 2| 0| 1| 0| 0| 1| 6| 9| 3| 0| 0| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATE                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    D 61 UM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +     +     M     +  +  +  +  +  +     +     +  +     +  +            |             
      Leukemia Mononuclear                 |    X                                      X     X  X                     |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
      Leukemia Mononuclear                 | X  X     X                                X     X  X                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +     +     M     M  M  +  +  +  +     +     +  +     +  +            |             
      Leukemia Mononuclear                 |    X                                      X     X  X                     |             
      Thymoma Benign                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +     +     M     +  +  +  +  M  M     +     M  +     M  M            |             
      Adenoma                              |                                                                          |             
      Fibroadenoma                         |    X                          X                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +     +     +     +  +  +  +  +  +     +     +  +     +  M            |             
      Basal Cell Carcinoma                 |                                                                          |             
      Leukemia Mononuclear                 |          X                                                               |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
      Leukemia Mononuclear                 |          X                                         X                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Carcinoma, Metastatic, Adrenal Gland |                                                             X            |             
      Carcinoma, Metastatic, Preputial     |                                                                          |             
          Gland                            |                                                                          |             
      Leukemia Mononuclear                 |    X     X                                X     X  X                     |             
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |             
          Primary Site                     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +     +     +     M  +  +  +  +  +     +     +  +     +  +            |             
      Leukemia Mononuclear                 |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                 +  +                     |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                 +  +                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 1| 6| 1| 6| 4| 6| 6| 2| 7| 7| 7| 4| 7| 4| 7| 6| 1| 6| 7| 4| 4| 4| 1|             
                             DAY ON TEST   | 3| 2| 7| 1| 7| 5| 7| 3| 2| 8| 3| 3| 3| 7| 2| 7| 1| 5| 7| 1| 1| 7| 7| 7| 7|             
                                           | 1| 5| 5| 0| 6| 8| 0| 7| 5| 8| 1| 2| 2| 0| 1| 0| 0| 1| 6| 9| 3| 0| 0| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATE                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    D 61 UM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                    +                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
      Leukemia Mononuclear                 |    X     X                                      X  X                     |             
      Renal Tubule, Adenoma                |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +     +     +     +  +  +  +  +  +     +     +  +     +  +            |             
      Leukemia Mononuclear                 | X  X     X                                X     X  X                     |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 4| 7| 7| 6| 6| 1| 7| 7| 7| 7| 7| 1| 4| 7| 6| 5|              |            |
                             DAY ON TEST   | 3| 3| 3| 6| 8| 3| 3| 9| 0| 7| 3| 3| 3| 3| 3| 7| 7| 2| 3| 0|              |            |
                                           | 1| 1| 2| 6| 5| 1| 2| 4| 5| 6| 1| 1| 1| 2| 2| 5| 0| 2| 9| 8|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     A      |
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |     L      |
    D 61 UM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  M  +  +  +  +     +  +  +  +  +        +  +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +     +  +  M  +  +        +  +  +               |  45        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  46        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  50        |
      Fibrosarcoma, Metastatic, Skin       |                               X                                          |          1 |
      Hepatocellular Adenoma               |                                                                          |          1 |
      Leukemia Mononuclear                 |             X        X  X           X              X                     |         19 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +                                                               |   3        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Mesothelioma Malignant               |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  50        |
      Leukemia Mononuclear                 |                         X                                                |          3 |
      Mesothelioma Malignant               |          X                                                               |          1 |
      Acinus, Adenoma                      |                                                    X                     |          1 |
      Acinus, Adenoma, Multiple            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
      Palate, Squamous Cell Papilloma      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  49        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  50        |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  49        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                         +                                                |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  50        |
      Leukemia Mononuclear                 |             X        X  X                                                |         12 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  42                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 4| 7| 7| 6| 6| 1| 7| 7| 7| 7| 7| 1| 4| 7| 6| 5|              |            |
                             DAY ON TEST   | 3| 3| 3| 6| 8| 3| 3| 9| 0| 7| 3| 3| 3| 3| 3| 7| 7| 2| 3| 0|              |            |
                                           | 1| 1| 2| 6| 5| 1| 2| 4| 5| 6| 1| 1| 1| 2| 2| 5| 0| 2| 9| 8|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     A      |
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |     L      |
    D 61 UM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Carcinoma                            |                                                                          |          1 |
      Leukemia Mononuclear                 |             X        X  X                          X                     |         13 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  50        |
      Leukemia Mononuclear                 |             X        X                             X                     |         13 |
      Pheochromocytoma Malignant           |                                                                          |          2 |
      Pheochromocytoma Benign              |    X  X                          X                    X                  |         13 |
      Bilateral, Pheochromocytoma Benign   |                                     X                                    |          6 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +     +  M  +  +  +        +  +  +               |  48        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  47        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | M  +  +  +  M  +  +  +  +     +  +  +  +  +        M  +  M               |  45        |
      Leukemia Mononuclear                 |                      X                                                   |          4 |
      Pars Distalis, Adenoma               |    X           X              X        X              X                  |         17 |
      Pars Distalis, Leukemia Mononuclear  |                         X                                                |          2 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      C-Cell, Adenoma                      |                X  X           X  X                                       |          6 |
      C-Cell, Adenoma, Multiple            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  49        |
      Mesothelioma Malignant               |          X                                                               |          2 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +        M  +  +               |  48        |
      Adenoma                              | X                 X                    X              X                  |          8 |
      Carcinoma                            |                                                          X               |          1 |
      Bilateral, Adenoma                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  48        |
      Leukemia Mononuclear                 |                      X                                                   |          2 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Bilateral, Interstitial Cell, Adenoma| X  X  X  X     X  X  X        X  X  X     X        X     X               |         37 |
      Interstitial Cell, Adenoma           |                         X              X                                 |         10 |
      Tunic, Mesothelioma Malignant        |          X                                                               |          2 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  43                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 4| 7| 7| 6| 6| 1| 7| 7| 7| 7| 7| 1| 4| 7| 6| 5|              |            |
                             DAY ON TEST   | 3| 3| 3| 6| 8| 3| 3| 9| 0| 7| 3| 3| 3| 3| 3| 7| 7| 2| 3| 0|              |            |
                                           | 1| 1| 2| 6| 5| 1| 2| 4| 5| 6| 1| 1| 1| 2| 2| 5| 0| 2| 9| 8|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     A      |
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |     L      |
    D 61 UM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  49        |
      Leukemia Mononuclear                 |                         X                                                |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  50        |
      Lumbar, Leukemia Mononuclear         |                                                                          |          1 |
      Mediastinal, Leukemia Mononuclear    |             X                                                            |          9 |
      Pancreatic, Leukemia Mononuclear     |             X                                                            |          4 |
      Renal, Leukemia Mononuclear          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  M  +               |  46        |
      Leukemia Mononuclear                 |             X           X                                                |         11 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  49        |
      Leukemia Mononuclear                 |             X           X                                                |         10 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  50        |
      Leukemia Mononuclear                 |             X        X  X           X              X                     |         19 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  M  +  M  +  M  +  +     +  +  M  M  +        +  +  +               |  41        |
      Leukemia Mononuclear                 |                      X                                                   |         10 |
      Thymoma Benign                       |                                           X                              |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  M  M  +  +  M  M  +  +     +  M  +  M  M        +  M  M               |  28        |
      Adenoma                              |                                                                          |          1 |
      Fibroadenoma                         |                                     X                                    |          3 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  M               |  48        |
      Basal Cell Carcinoma                 |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |                               X                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |          +                                                               |   1        |
      Mesothelioma Malignant               |          X                                                               |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  50        |
      Leukemia Mononuclear                 |             X                                                            |          6 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  50        |
      Alveolar/Bronchiolar Adenoma         |          X        X                                                      |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  44                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 4| 7| 7| 6| 6| 1| 7| 7| 7| 7| 7| 1| 4| 7| 6| 5|              |            |
                             DAY ON TEST   | 3| 3| 3| 6| 8| 3| 3| 9| 0| 7| 3| 3| 3| 3| 3| 7| 7| 2| 3| 0|              |            |
                                           | 1| 1| 2| 6| 5| 1| 2| 4| 5| 6| 1| 1| 1| 2| 2| 5| 0| 2| 9| 8|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     A      |
    UNTREATE                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |     L      |
    D 61 UM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Carcinoma, Metastatic, Adrenal Gland |                                                                          |          1 |
      Carcinoma, Metastatic, Preputial     |                                                                          |            |
          Gland                            |                                                          X               |          1 |
      Leukemia Mononuclear                 |             X        X  X                                                |         15 |
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |            |
          Primary Site                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | M  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  M               |  47        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Squamous Cell Papilloma              |                                     X                                    |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |    +  +     +                                                            |   6        |
      Squamous Cell Papilloma              |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Eye                                     |    +                                               +                     |   6        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  50        |
      Leukemia Mononuclear                 |             X           X                                                |         13 |
      Renal Tubule, Adenoma                |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  M  +  +  +  +     +  +  +  +  +        +  +  +               |  48        |
      Leukemia Mononuclear                 |                      X                                                   |          2 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +               |  50        |
      Leukemia Mononuclear                 |             X        X  X           X              X                     |         19 |
      Mesothelioma Malignant               |          X                                                               |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  45                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 1| 7| 6| 6| 7| 7| 4| 1| 6| 7| 7| 6| 1| 3| 7| 7| 6| 5| 4| 1| 7| 6| 6| 6|             
                             DAY ON TEST   | 7| 7| 3| 2| 1| 3| 1| 7| 7| 7| 3| 3| 2| 7| 9| 2| 3| 2| 8| 8| 7| 3| 5| 4| 2|             
                                           | 6| 6| 0| 0| 9| 0| 8| 0| 6| 2| 0| 0| 6| 6| 6| 8| 0| 6| 8| 1| 5| 0| 8| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.25%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
     61LM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |       +  +  +  M  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                       X                  |             
                                            __________________________________________________________________________|             
   Intestine Large                         |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  A|             
      Leukemia Mononuclear                 |                                                    X                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |       +  +  +  +  +        +  +  M  +     +  +  M  +  +  +     +  +  +  A|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                       X                  |             
      Polyp Adenomatous                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small                         |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  A|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                       X                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  A|             
      Leukemia Mononuclear                 |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  A|             
      Leukemia Mononuclear                 |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |          X        X                 X           X  X                 X  X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                       X                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                     +                 +  +               |             
      Leukemia Mononuclear                 |                                     X                                    |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                       X                  |             
                                            __________________________________________________________________________|             
   Pancreas                                |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  A|             
      Leukemia Mononuclear                 |                                     X              X                     |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                       X                  |             
      Acinus, Adenoma                      |       X                                                                  |             
      Acinus, Adenoma, Multiple            |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                    X                    X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                       X                  |             
      Sarcoma                              |       X                                                                  |             
                                            __________________________________________________________________________|             
   Stomach                                 |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |       +  +     +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 1| 7| 6| 6| 7| 7| 4| 1| 6| 7| 7| 6| 1| 3| 7| 7| 6| 5| 4| 1| 7| 6| 6| 6|             
                             DAY ON TEST   | 7| 7| 3| 2| 1| 3| 1| 7| 7| 7| 3| 3| 2| 7| 9| 2| 3| 2| 8| 8| 7| 3| 5| 4| 2|             
                                           | 6| 6| 0| 0| 9| 0| 8| 0| 6| 2| 0| 0| 6| 6| 6| 8| 0| 6| 8| 1| 5| 0| 8| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.25%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
     61LM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |                                     X              X                    X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                       X                  |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |       +  +     +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                     X              X                    X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |          X                          X              X                 X  X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |          X                                         X                 X  X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                       X                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |       +  +  +  +  +        +  +  +  +     +  +  +  M  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |          X                          X                                X  X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                       X                  |             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              |                   X                                               X      |             
      Bilateral, Pheochromocytoma Benign   |       X                       X              X                 X         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  A|             
      Adenoma                              |                               X  X                                       |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |       +  +  +  M  +        +  +  +  +     +  +  +  M  +  M     +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               |       X        X  X        X  X     X                             X      |             
      Pars Distalis, Adenoma, Multiple     |                                                                          |             
      Pars Distalis, Leukemia Mononuclear  |          X                          X              X                     |             
      Pars Distalis, Lymphoma Malignant    |                                                                          |             
          Undifferentiated Cell Type       |                                                       X                  |             
      Pars Intermedia, Lymphoma Malignant  |                                                                          |             
          Undifferentiated Cell Type       |                                                       X                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                         X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 1| 7| 6| 6| 7| 7| 4| 1| 6| 7| 7| 6| 1| 3| 7| 7| 6| 5| 4| 1| 7| 6| 6| 6|             
                             DAY ON TEST   | 7| 7| 3| 2| 1| 3| 1| 7| 7| 7| 3| 3| 2| 7| 9| 2| 3| 2| 8| 8| 7| 3| 5| 4| 2|             
                                           | 6| 6| 0| 0| 9| 0| 8| 0| 6| 2| 0| 0| 6| 6| 6| 8| 0| 6| 8| 1| 5| 0| 8| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.25%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
     61LM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      C-Cell, Adenoma                      |       X                    X                          X                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                                     X                                    |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
      Adenoma                              |                X                 X           X     X     X        X      |             
      Leukemia Mononuclear                 |                                                    X                    X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                       X                  |             
                                            __________________________________________________________________________|             
   Prostate                                |       +  +  +  +  +        +  +  M  +     +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                    X                     |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                       X                  |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                    X                    X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                       X                  |             
                                            __________________________________________________________________________|             
   Testes                                  |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                    X                     |             
      Bilateral, Interstitial Cell, Adenoma|       X     X  X  X        X  X  X  X           X  X           X  X  X  X|             
      Interstitial Cell, Adenoma           |          X                                                               |             
      Tunic, Mesothelioma Malignant        |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                    X                    X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                       X                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
      Axillary, Lymphoma Malignant         |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |          X        X                                X                 X  X|             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Undifferentiated Cell Type       |                                                       X                  |             
      Pancreatic, Leukemia Mononuclear     |                                     X                                   X|             
      Renal, Lymphoma Malignant            |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 1| 7| 6| 6| 7| 7| 4| 1| 6| 7| 7| 6| 1| 3| 7| 7| 6| 5| 4| 1| 7| 6| 6| 6|             
                             DAY ON TEST   | 7| 7| 3| 2| 1| 3| 1| 7| 7| 7| 3| 3| 2| 7| 9| 2| 3| 2| 8| 8| 7| 3| 5| 4| 2|             
                                           | 6| 6| 0| 0| 9| 0| 8| 0| 6| 2| 0| 0| 6| 6| 6| 8| 0| 6| 8| 1| 5| 0| 8| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.25%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
     61LM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |       +  +  +  +  +        +  +  +  +     +  M  +  +  +  +     +  +  M  +|             
      Leukemia Mononuclear                 |          X        X                 X              X                    X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                       X                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |          X        X                 X              X                 X  X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                       X                  |             
                                            __________________________________________________________________________|             
   Spleen                                  |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |          X        X                 X           X  X                 X  X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                       X                  |             
      Sarcoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |       +  +  +  M  +        +  M  +  +     +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |          X        X                 X              X                 X  X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       +  +  M  M  M        M  M  M  +     +  +  M  M  +  +     M  M  M  +|             
      Fibroadenoma                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
      Keratoacanthoma                      |                                                                          |             
      Leukemia Mononuclear                 |                                                    X                     |             
      Squamous Cell Papilloma              |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                            X                                             |             
      Subcutaneous Tissue, Lipoma          |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
      Osteosarcoma                         |             X                                                            |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                    +                    +|             
      Leukemia Mononuclear                 |                                                    X                    X|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                    X                     |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Leukemia Mononuclear                 |          X        X                 X              X                 X  X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 1| 7| 6| 6| 7| 7| 4| 1| 6| 7| 7| 6| 1| 3| 7| 7| 6| 5| 4| 1| 7| 6| 6| 6|             
                             DAY ON TEST   | 7| 7| 3| 2| 1| 3| 1| 7| 7| 7| 3| 3| 2| 7| 9| 2| 3| 2| 8| 8| 7| 3| 5| 4| 2|             
                                           | 6| 6| 0| 0| 9| 0| 8| 0| 6| 2| 0| 0| 6| 6| 6| 8| 0| 6| 8| 1| 5| 0| 8| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.25%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
     61LM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                       X                  |             
      Osteosarcoma, Metastatic, Bone       |             X                                                            |             
      Pheochromocytoma Malignant,          |                                                                          |             
          Metastatic, Adrenal Gland        |                                                                          |             
      Mediastinum, Sarcoma, Metastatic,    |                                                                          |             
           Salivary Glands                 |       X                                                                  |             
                                            __________________________________________________________________________|             
   Nose                                    |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                     X              X                    X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                       X                  |             
                                            __________________________________________________________________________|             
   Trachea                                 |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                           +                              |             
      Squamous Cell Carcinoma              |                                           X                              |             
                                            __________________________________________________________________________|             
   Eye                                     |          +                                                               |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |          X                          X              X                 X  X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                       X                  |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |       +  +  +  +  +        +  +  M  +     +  +  +  +  +  +     +  +  +  A|             
      Leukemia Mononuclear                 |          X                                                               |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         |       +  +  +  +  +        +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |          X        X                 X           X  X                 X  X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                       X                  |             
      Mesothelioma Malignant               |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 6| 7| 1| 7| 6| 1| 7| 1| 7| 4| 1| 4| 7| 4| 4| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 7| 2| 6| 3| 7| 3| 5| 7| 3| 7| 3| 6| 7| 7| 3| 7| 7| 3| 7| 3| 3| 3| 2|             
                                           | 0| 0| 0| 8| 8| 0| 6| 0| 3| 6| 0| 5| 0| 7| 5| 0| 0| 0| 0| 0| 0| 0| 0| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.25%                                  | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
     61LM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +     +  +  +     +  +     +     +  A        +        +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +     +  +  +     +  +     +     +  A        +        +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +     +  +  +     +  +     +     +  A        +        +     +  +  M  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
      Polyp Adenomatous                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +     +  +  +     +  +     +     +  A        +        +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +     +  +  +     +  +     +     +  A        +        +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +     +  +  +     +  +     +     +  A        +        +     +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +     +  +  +     +  +     +     +  A        +        +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +     +  +  +     +  +     +     +  A        +        +     +  +  M  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
      Leukemia Mononuclear                 | X        X     X        X           X  X                 X     X     X  X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +                          +                                 |             
      Leukemia Mononuclear                 |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +     +  M  +     +  +     +     +  +        +        +     +  +  +  +|             
      Leukemia Mononuclear                 |                                        X                                 |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
      Acinus, Adenoma                      |                                                          X        X      |             
      Acinus, Adenoma, Multiple            |                               X                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
      Leukemia Mononuclear                 |                                        X                                 |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
      Sarcoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 6| 7| 1| 7| 6| 1| 7| 1| 7| 4| 1| 4| 7| 4| 4| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 7| 2| 6| 3| 7| 3| 5| 7| 3| 7| 3| 6| 7| 7| 3| 7| 7| 3| 7| 3| 3| 3| 2|             
                                           | 0| 0| 0| 8| 8| 0| 6| 0| 3| 6| 0| 5| 0| 7| 5| 0| 0| 0| 0| 0| 0| 0| 0| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.25%                                  | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
     61LM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +     +  +  +     +  +     +     +  A        +        +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
      Leukemia Mononuclear                 |          X     X        X              X                                X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
      Leukemia Mononuclear                 |                         X              X                                 |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
      Leukemia Mononuclear                 |                         X              X                                 |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              | X                             X     X           X                    X   |             
      Bilateral, Pheochromocytoma Benign   |                                                          X               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +     +  M  +     +  +     +     +  +        +        +     +  +  +  +|             
      Adenoma                              |                                                                         X|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +     +  +  +     +  M     +     M  +        +        +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               |             X  X        X                                            X   |             
      Pars Distalis, Adenoma, Multiple     |                               X                                          |             
      Pars Distalis, Leukemia Mononuclear  |                                        X                                 |             
      Pars Distalis, Lymphoma Malignant    |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
      Pars Intermedia, Lymphoma Malignant  |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +     +  +  +     +  +     +     +  A        +        +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 6| 7| 1| 7| 6| 1| 7| 1| 7| 4| 1| 4| 7| 4| 4| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 7| 2| 6| 3| 7| 3| 5| 7| 3| 7| 3| 6| 7| 7| 3| 7| 7| 3| 7| 3| 3| 3| 2|             
                                           | 0| 0| 0| 8| 8| 0| 6| 0| 3| 6| 0| 5| 0| 7| 5| 0| 0| 0| 0| 0| 0| 0| 0| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.25%                                  | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
     61LM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      C-Cell, Adenoma                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
      Leukemia Mononuclear                 |                                        X                                 |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
      Adenoma                              | X           X  X                    X                             X      |             
      Leukemia Mononuclear                 |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
      Leukemia Mononuclear                 |                                        X                                 |             
      Bilateral, Interstitial Cell, Adenoma| X  X     X     X     X        X     X  X        X        X     X  X  X  X|             
      Interstitial Cell, Adenoma           |                                                                          |             
      Tunic, Mesothelioma Malignant        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
      Leukemia Mononuclear                 |          X     X        X              X                                X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
      Axillary, Lymphoma Malignant         |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |          X     X        X                                X              X|             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
      Pancreatic, Leukemia Mononuclear     |          X                                                              X|             
      Renal, Lymphoma Malignant            |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 6| 7| 1| 7| 6| 1| 7| 1| 7| 4| 1| 4| 7| 4| 4| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 7| 2| 6| 3| 7| 3| 5| 7| 3| 7| 3| 6| 7| 7| 3| 7| 7| 3| 7| 3| 3| 3| 2|             
                                           | 0| 0| 0| 8| 8| 0| 6| 0| 3| 6| 0| 5| 0| 7| 5| 0| 0| 0| 0| 0| 0| 0| 0| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.25%                                  | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
     61LM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +     +  +  +     +  +     +     +  +        M        +     +  +  +  +|             
      Leukemia Mononuclear                 |          X     X        X              X                             X  X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
      Leukemia Mononuclear                 |          X     X                       X                 X     X        X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
      Leukemia Mononuclear                 | X        X     X        X           X  X                 X     X     X  X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
      Sarcoma                              |                                                                      X   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +     +  +  +     +  M     +     +  +        +        +     +  +  +  +|             
      Leukemia Mononuclear                 |          X     X                       X                 X              X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M     +  M  M     M  M     +     +  +        M        M     M  M  M  +|             
      Fibroadenoma                         |                               X                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
      Keratoacanthoma                      | X                                                                        |             
      Leukemia Mononuclear                 |                                                                          |             
      Squamous Cell Papilloma              |          X                                                               |             
      Subcutaneous Tissue, Fibroma         | X        X                                                               |             
      Subcutaneous Tissue, Lipoma          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
      Osteosarcoma                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
      Leukemia Mononuclear                 |                         X              X                                 |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Leukemia Mononuclear                 | X        X     X        X           X  X                 X           X  X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 6| 7| 1| 7| 6| 1| 7| 1| 7| 4| 1| 4| 7| 4| 4| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 7| 2| 6| 3| 7| 3| 5| 7| 3| 7| 3| 6| 7| 7| 3| 7| 7| 3| 7| 3| 3| 3| 2|             
                                           | 0| 0| 0| 8| 8| 0| 6| 0| 3| 6| 0| 5| 0| 7| 5| 0| 0| 0| 0| 0| 0| 0| 0| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.25%                                  | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
     61LM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
      Pheochromocytoma Malignant,          |                                                                          |             
          Metastatic, Adrenal Gland        |                                                                          |             
      Mediastinum, Sarcoma, Metastatic,    |                                                                          |             
           Salivary Glands                 |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
      Leukemia Mononuclear                 |                                        X                                 |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |    +                                                                     |             
      Squamous Cell Carcinoma              |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +                                            +                        |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                 +                        |             
      Adenoma                              |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
      Leukemia Mononuclear                 |                X        X              X                                X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +     +  +  +     +  +     +     +  +        +        +     +  +  +  +|             
      Leukemia Mononuclear                 | X        X     X        X           X  X                 X     X     X  X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 1| 7| 7| 7| 4| 7| 6| 7| 7| 3|              |            |
                             DAY ON TEST   | 3| 3| 3| 7| 7| 3| 3| 3| 2| 7| 7| 3| 3| 3| 7| 3| 7| 3| 3| 6|              |            |
                                           | 0| 0| 0| 0| 0| 1| 0| 0| 3| 0| 6| 1| 1| 1| 0| 1| 3| 1| 1| 7|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |     A      |
    0.25%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |     L      |
     61LM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +        +  +  +  +        M  +  +     +  +  +  +  +               |  48        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  48        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  M  +        +  +  +  +        +  +  +     +  +  +  +  +               |  44        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
      Polyp Adenomatous                    | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  M  +        +  +  +  +        +  +  +     +  +  +  +  +               |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  48        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  48        |
      Leukemia Mononuclear                 |                         X                                                |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  47        |
      Leukemia Mononuclear                 |                         X                                                |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  50        |
      Leukemia Mononuclear                 |       X                 X                          X  X                  |         21 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                          X               |          2 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   5        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  48        |
      Leukemia Mononuclear                 |                         X                             X                  |          5 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
      Acinus, Adenoma                      |                                                                          |          3 |
      Acinus, Adenoma, Multiple            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  50        |
      Leukemia Mononuclear                 |                                                                          |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  56                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 1| 7| 7| 7| 4| 7| 6| 7| 7| 3|              |            |
                             DAY ON TEST   | 3| 3| 3| 7| 7| 3| 3| 3| 2| 7| 7| 3| 3| 3| 7| 3| 7| 3| 3| 6|              |            |
                                           | 0| 0| 0| 0| 0| 1| 0| 0| 3| 0| 6| 1| 1| 1| 0| 1| 3| 1| 1| 7|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |     A      |
    0.25%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |     L      |
     61LM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
      Sarcoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +        +  +  +  +        +  +  +     +  +  +  M  +               |  48        |
      Leukemia Mononuclear                 |                                                                          |          3 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
      Squamous Cell Papilloma              |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  48        |
      Leukemia Mononuclear                 |                         X                                                |          4 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  50        |
      Leukemia Mononuclear                 |                         X                             X                  |         12 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  50        |
      Leukemia Mononuclear                 |                                                       X                  |          7 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                          X               |          2 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  49        |
      Leukemia Mononuclear                 |                                                       X                  |          7 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                          X               |          2 |
      Pheochromocytoma Malignant           |                                              X                           |          1 |
      Pheochromocytoma Benign              |                X     X  X                             X                  |         11 |
      Bilateral, Pheochromocytoma Benign   |                                                    X                     |          6 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +        +  +  +  +        +  +  +     +  +  M  +  +               |  47        |
      Adenoma                              |       X                                                                  |          4 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  44        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +        +  +  +  +        +  +  +     +  +  +  +  M               |  49        |
      Leukemia Mononuclear                 |                         X                                                |          1 |
      Pars Distalis, Adenoma               | X              X     X  X        X     X        X                        |         18 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  57                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 1| 7| 7| 7| 4| 7| 6| 7| 7| 3|              |            |
                             DAY ON TEST   | 3| 3| 3| 7| 7| 3| 3| 3| 2| 7| 7| 3| 3| 3| 7| 3| 7| 3| 3| 6|              |            |
                                           | 0| 0| 0| 0| 0| 1| 0| 0| 3| 0| 6| 1| 1| 1| 0| 1| 3| 1| 1| 7|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |     A      |
    0.25%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |     L      |
     61LM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Adenoma, Multiple     |                   X                                                      |          2 |
      Pars Distalis, Leukemia Mononuclear  |                                                                          |          4 |
      Pars Distalis, Lymphoma Malignant    |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
      Pars Intermedia, Lymphoma Malignant  |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
      C-Cell, Adenoma                      |    X                                               X                     |          5 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                      +                                                   |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  50        |
      Adenoma                              |       X                             X                                    |         13 |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  50        |
      Leukemia Mononuclear                 |                                                       X                  |          3 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                          X               |          2 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Bilateral, Interstitial Cell, Adenoma|    X  X        X  X  X  X        X  X  X     X     X  X                  |         40 |
      Interstitial Cell, Adenoma           | X                                               X                        |          3 |
      Tunic, Mesothelioma Malignant        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  58                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 1| 7| 7| 7| 4| 7| 6| 7| 7| 3|              |            |
                             DAY ON TEST   | 3| 3| 3| 7| 7| 3| 3| 3| 2| 7| 7| 3| 3| 3| 7| 3| 7| 3| 3| 6|              |            |
                                           | 0| 0| 0| 0| 0| 1| 0| 0| 3| 0| 6| 1| 1| 1| 0| 1| 3| 1| 1| 7|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |     A      |
    0.25%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |     L      |
     61LM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  50        |
      Leukemia Mononuclear                 |                         X                             X                  |          9 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  50        |
      Axillary, Lymphoma Malignant         |                                                                          |            |
          Undifferentiated Cell Type       |                                                          X               |          1 |
      Lumbar, Lymphoma Malignant           |                                                                          |            |
          Undifferentiated Cell Type       |                                                          X               |          1 |
      Mediastinal, Leukemia Mononuclear    |                         X                          X  X                  |         13 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Undifferentiated Cell Type       |                                                          X               |          2 |
      Pancreatic, Leukemia Mononuclear     |                                                    X                     |          5 |
      Renal, Lymphoma Malignant            |                                                                          |            |
          Undifferentiated Cell Type       |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +        M  +  +  +        +  +  +     +  +  +  +  +               |  46        |
      Leukemia Mononuclear                 |                         X                             X                  |         13 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  50        |
      Leukemia Mononuclear                 |                         X                          X  X                  |         15 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                          X               |          2 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  50        |
      Leukemia Mononuclear                 |       X                 X                          X  X                  |         21 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                          X               |          2 |
      Sarcoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +        +  +  +  +        M  M  +     M  +  +  +  M               |  43        |
      Leukemia Mononuclear                 |                         X                             X                  |         13 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M        M  M  +  M        M  M  +     +  M  +  +  M               |  18        |
      Fibroadenoma                         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  50        |
      Keratoacanthoma                      |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  59                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 1| 7| 7| 7| 4| 7| 6| 7| 7| 3|              |            |
                             DAY ON TEST   | 3| 3| 3| 7| 7| 3| 3| 3| 2| 7| 7| 3| 3| 3| 7| 3| 7| 3| 3| 6|              |            |
                                           | 0| 0| 0| 0| 0| 1| 0| 0| 3| 0| 6| 1| 1| 1| 0| 1| 3| 1| 1| 7|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |     A      |
    0.25%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |     L      |
     61LM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Squamous Cell Papilloma              |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |                   X                    X                                 |          5 |
      Subcutaneous Tissue, Lipoma          |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  50        |
      Osteosarcoma                         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   2        |
      Leukemia Mononuclear                 |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  50        |
      Leukemia Mononuclear                 |                                                                          |          3 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  50        |
      Alveolar/Bronchiolar Adenoma         |                                                    X                     |          1 |
      Leukemia Mononuclear                 |       X                 X                          X  X                  |         19 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                          X               |          2 |
      Osteosarcoma, Metastatic, Bone       |                                                                          |          1 |
      Pheochromocytoma Malignant,          |                                                                          |            |
          Metastatic, Adrenal Gland        |                                              X                           |          1 |
      Mediastinum, Sarcoma, Metastatic,    |                                                                          |            |
           Salivary Glands                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  50        |
      Leukemia Mononuclear                 |                                                                          |          4 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                   +                    +                                 |   4        |
      Squamous Cell Carcinoma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Eye                                     |                   +  +                 +                                 |   6        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
      Adenoma                              |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  60                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 1| 7| 7| 7| 4| 7| 6| 7| 7| 3|              |            |
                             DAY ON TEST   | 3| 3| 3| 7| 7| 3| 3| 3| 2| 7| 7| 3| 3| 3| 7| 3| 7| 3| 3| 6|              |            |
                                           | 0| 0| 0| 0| 0| 1| 0| 0| 3| 0| 6| 1| 1| 1| 0| 1| 3| 1| 1| 7|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |     A      |
    0.25%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |     L      |
     61LM                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  50        |
      Leukemia Mononuclear                 |       X                 X                          X  X                  |         13 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                          X               |          2 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  48        |
      Leukemia Mononuclear                 |                                                       X                  |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +        +  +  +  +        +  +  +     +  +  +  +  +               |  50        |
      Leukemia Mononuclear                 |       X                 X                          X  X                  |         21 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                          X               |          2 |
      Mesothelioma Malignant               |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  61                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 7| 7| 1| 7| 1| 6| 7| 7| 6| 6| 4| 0| 7| 7| 7| 1| 7| 7| 4| 6| 1|             
                             DAY ON TEST   | 2| 7| 2| 2| 2| 2| 7| 2| 7| 6| 2| 2| 9| 5| 7| 5| 2| 2| 0| 7| 2| 2| 7| 7| 7|             
                                           | 9| 0| 9| 9| 9| 9| 5| 9| 6| 8| 9| 9| 4| 4| 0| 2| 9| 9| 4| 5| 9| 9| 0| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.5%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    61HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +     +  +  +  +     +     +  +  +  +  A        +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +     +  +  +  +     +     A  +  +  +  A        +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +  +  +  +     +     +  +  +  M  M        +  +  +     M  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +     +  +  +  +     +     A  +  +  +  A        +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +     +  +  +  +     +     +  +  +  +  A        +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     +  +  +  +     +     +  +  +  +  A        +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +     +  +  +  +     +     A  +  +  +  A        +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +     +  +  +  +     +     A  +  +  +  A        +  +  +     +  +     +   |             
      Sarcoma                              |             X                                                            |             
                                            __________________________________________________________________________|             
   Liver                                   | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
      Adenocarcinoma, Metastatic, Lung     |                                        X                                 |             
      Leukemia Mononuclear                 | X           X              X        X           X           X  X         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +  +  +  +     +     +  +  +  +  M        +  +  +     +  +     +   |             
      Leukemia Mononuclear                 |                                                                          |             
      Acinus, Adenoma                      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +  +  +  +     +     A  +  +  +  +        +  +  +     +  +     +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Tongue                                  | +                                                                        |             
      Squamous Cell Papilloma              | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
      Leukemia Mononuclear                 |                            X                    X                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
      Leukemia Mononuclear                 |                            X                    X                        |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
      Leukemia Mononuclear                 |                            X                    X                        |             
      Pheochromocytoma Benign              |       X                    X  X  X              X                    X   |             
      Bilateral, Pheochromocytoma Benign   |                                     X                          X         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +  +  +  +     +     +  +  +  +  M        +  +  +     +  +     +   |             
      Adenoma                              |                                                       X                  |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +     M  +  +  +     +     +  +  +  +  +        +  +  +     M  +     +   |             
      Adenoma                              |                X                                                         |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
      Leukemia Mononuclear                 |                                                 X                        |             
      Pars Distalis, Adenoma               | X     X  X     X     X           X  X           X  X  X        X     X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 7| 7| 1| 7| 1| 6| 7| 7| 6| 6| 4| 0| 7| 7| 7| 1| 7| 7| 4| 6| 1|             
                             DAY ON TEST   | 2| 7| 2| 2| 2| 2| 7| 2| 7| 6| 2| 2| 9| 5| 7| 5| 2| 2| 0| 7| 2| 2| 7| 7| 7|             
                                           | 9| 0| 9| 9| 9| 9| 5| 9| 6| 8| 9| 9| 4| 4| 0| 2| 9| 9| 4| 5| 9| 9| 0| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.5%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    61HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Adenoma, Multiple     |                                                                          |             
      Pars Distalis, Leukemia Mononuclear  |                                                                          |             
      Pars Distalis, Lymphoma Malignant    |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +     +  +  +  +     +     A  +  +  +  +        +  +  +     +  +     +   |             
      C-Cell, Adenoma                      | X                                X                                       |             
      Follicular Cell, Adenoma             |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
      Bilateral, Adenoma                   |                X                                                         |             
                                            __________________________________________________________________________|             
   Prostate                                | +     +  +  +  +     +     +  +  +  M  +        +  +  +     M  +     +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Testes                                  | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
      Leukemia Mononuclear                 |                                                                          |             
      Bilateral, Interstitial Cell, Adenoma| X     X  X  X  X     X     X  X        X        X           X  X     X   |             
      Interstitial Cell, Adenoma           |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +  +  +  +     +     A  +  +  +  +        +  +  +     +  +     +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
      Axillary, Leukemia Mononuclear       |                                                 X                        |             
      Mediastinal, Leukemia Mononuclear    |                            X                    X                        |             
      Pancreatic, Leukemia Mononuclear     |                                                 X                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +     +  +  +  +     +     M  +  +  +  +        +  +  +     +  +     +   |             
      Leukemia Mononuclear                 |                                                 X                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | M     +  +  M  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
      Leukemia Mononuclear                 |                            X                    X                        |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
      Leukemia Mononuclear                 | X           X              X        X           X           X  X         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
      Leukemia Mononuclear                 |                            X                    X                        |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +     +  +  M  +     M     M  M  +  +  M        +  +  +     M  M     +   |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 7| 7| 1| 7| 1| 6| 7| 7| 6| 6| 4| 0| 7| 7| 7| 1| 7| 7| 4| 6| 1|             
                             DAY ON TEST   | 2| 7| 2| 2| 2| 2| 7| 2| 7| 6| 2| 2| 9| 5| 7| 5| 2| 2| 0| 7| 2| 2| 7| 7| 7|             
                                           | 9| 0| 9| 9| 9| 9| 5| 9| 6| 8| 9| 9| 4| 4| 0| 2| 9| 9| 4| 5| 9| 9| 0| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.5%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    61HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
      Keratoacanthoma                      |                      X                                                   |             
      Leukemia Mononuclear                 |                                                                          |             
      Squamous Cell Carcinoma              |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
      Astrocytoma Malignant                |                                                                          |             
      Leukemia Mononuclear                 |                            X                                             |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
      Adenocarcinoma                       |                                        X                                 |             
      Alveolar/Bronchiolar Adenoma         |       X                                                        X         |             
      Leukemia Mononuclear                 | X                                   X           X           X            |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
      Mediastinum, Adenocarcinoma,         |                                                                          |             
          Metastatic, Lung                 |                                        X                                 |             
                                            __________________________________________________________________________|             
   Nose                                    | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                       +                  |             
                                            __________________________________________________________________________|             
   Eye                                     |                      +           +                 +  +                  |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                       +                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
      Adenocarcinoma, Metastatic, Lung     |                                        X                                 |             
      Leukemia Mononuclear                 | X                          X        X           X              X         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +  +  +  +     +     +  +  +  +  +        +  +  +     M  +     +   |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +     +  +  +  +     +     +  +  +  +  +        +  +  +     +  +     +   |             
      Leukemia Mononuclear                 | X           X              X        X           X           X  X         |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 1| 6| 1| 1| 1| 7| 7| 7| 7| 1| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 3|             
                             DAY ON TEST   | 1| 7| 9| 7| 7| 7| 2| 2| 2| 2| 7| 7| 2| 1| 8| 2| 2| 2| 2| 2| 3| 0| 9| 5| 6|             
                                           | 4| 5| 4| 6| 5| 6| 9| 9| 9| 9| 6| 0| 9| 5| 8| 9| 9| 9| 9| 9| 0| 2| 4| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.5%                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    61HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sarcoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Metastatic, Lung     |                                                                          |             
      Leukemia Mononuclear                 |       X                                X  X              X     X  X      |             
                                            __________________________________________________________________________|             
   Mesentery                               |       M                                                                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Acinus, Adenoma                      |                            X                                         X   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tongue                                  |                                        +                                 |             
      Squamous Cell Papilloma              |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pheochromocytoma Benign              | X     X           X        X        X                 X                  |             
      Bilateral, Pheochromocytoma Benign   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                          X               |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M     +           +  +  M  +        +  +  +  M  M  +  +  +  +  +  M  +  +|             
      Adenoma                              |                                                             X            |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               |                   X                 X  X  X           X  X     X  X     X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 1| 6| 1| 1| 1| 7| 7| 7| 7| 1| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 3|             
                             DAY ON TEST   | 1| 7| 9| 7| 7| 7| 2| 2| 2| 2| 7| 7| 2| 1| 8| 2| 2| 2| 2| 2| 3| 0| 9| 5| 6|             
                                           | 4| 5| 4| 6| 5| 6| 9| 9| 9| 9| 6| 0| 9| 5| 8| 9| 9| 9| 9| 9| 0| 2| 4| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.5%                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    61HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Adenoma, Multiple     |                                                                          |             
      Pars Distalis, Leukemia Mononuclear  |                                                                          |             
      Pars Distalis, Lymphoma Malignant    |                                                                          |             
          Undifferentiated Cell Type       |                                           X                              |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                                              X  X           X            |             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                            X              X                              |             
      Leukemia Mononuclear                 |                                                                          |             
      Bilateral, Adenoma                   |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Bilateral, Interstitial Cell, Adenoma| X     X           X  X  X  X        X  X     X  X  X  X  X  X     X  X   |             
      Interstitial Cell, Adenoma           |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Axillary, Leukemia Mononuclear       |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |                                           X              X        X      |             
      Pancreatic, Leukemia Mononuclear     |                                           X                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +     +           +  +  +  +        +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                           X                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                           X              X               |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                                X  X              X     X  X      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +     +           +  +  +  +        M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M     M           M  +  M  M        M  M  M  +  M  +  +  M  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 1| 6| 1| 1| 1| 7| 7| 7| 7| 1| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 3|             
                             DAY ON TEST   | 1| 7| 9| 7| 7| 7| 2| 2| 2| 2| 7| 7| 2| 1| 8| 2| 2| 2| 2| 2| 3| 0| 9| 5| 6|             
                                           | 4| 5| 4| 6| 5| 6| 9| 9| 9| 9| 6| 0| 9| 5| 8| 9| 9| 9| 9| 9| 0| 2| 4| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.5%                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    61HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | M     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Keratoacanthoma                      |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
      Squamous Cell Carcinoma              |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Astrocytoma Malignant                |       X                                                                  |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                      +   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                                                                          |             
      Alveolar/Bronchiolar Adenoma         |                                              X                           |             
      Leukemia Mononuclear                 |                                                          X     X  X      |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                           X                              |             
      Mediastinum, Adenocarcinoma,         |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                +         |             
                                            __________________________________________________________________________|             
   Eye                                     | +                          +                                            +|             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                            +                                             |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Metastatic, Lung     |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +     +           +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                                X  X              X     X  X      |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 4| 4| 4| 7| 4| 7| 6| 4| 7| 6| 5| 5| 4| 7| 4| 4| 1| 6|              |            |
                             DAY ON TEST   | 3| 5| 7| 3| 3| 3| 7| 2| 0| 7| 3| 9| 7| 5| 7| 3| 7| 7| 7| 8|              |            |
                                           | 0| 3| 0| 6| 0| 0| 0| 9| 5| 0| 0| 6| 0| 7| 0| 0| 0| 0| 5| 0|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |     A      |
    0.5%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |     L      |
    61HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +     +  +  +     +  +     +  +  +  +     +           +               |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +     +  +  +     +  +     +  +  +  +     +           +               |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +     +  +  +     +  +     +  +  +  A     +           +               |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +     +  +  +     +  +     +  +  +  A     +           +               |  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +     +  +  +     +  +     +  +  +  +     +           +               |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +     +  +  +     +  +     +  +  +  A     +           +               |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +     +  +  +     +  +     +  +  +  A     +           +               |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +     +  +  +     +  +     +  +  +  A     +           +               |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +     +  +  +     +  +     +  +  +  A     +           +               |  46        |
      Sarcoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +     +  +  +     +  +     +  +  +  +     +           +               |  49        |
      Adenocarcinoma, Metastatic, Lung     |                                                                          |          1 |
      Leukemia Mononuclear                 |                         X           X                    X               |         16 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |             M                          +                                 |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +     +  +  +     +  +     +  +  +  +     +           +               |  48        |
      Leukemia Mononuclear                 |                         X           X                                    |          2 |
      Acinus, Adenoma                      |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +     +  +  +     +  +     +  +  +  +     +           +               |  48        |
      Leukemia Mononuclear                 |                                     X                                    |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +     +  +  +     +  +     +  +  +  +     +           +               |  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +     +  +  +     +  +     +  +  +  +     +           +               |  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +     +  +  +     +  +     +  +  +  A     +           +               |  48        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |          +                                                               |   3        |
      Squamous Cell Papilloma              |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +     +  +  +     +  +     +  +  +  +     +           +               |  49        |
      Leukemia Mononuclear                 |                         X           X                                    |          5 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +     +  M  +     +  +     +  +  +  +     +           +               |  48        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +     +  M  +     +  +     +  +  +  +     +           +               |  48        |
      Leukemia Mononuclear                 |                         X           X                    X               |          5 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +     +  M  +     +  +     +  +  +  +     +           +               |  48        |
      Leukemia Mononuclear                 |                         X           X                    X               |          5 |
      Pheochromocytoma Benign              |                               X     X                                    |         14 |
      Bilateral, Pheochromocytoma Benign   |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +     +  +  +     +  +     +  +  +  +     +           +               |  48        |
      Adenoma                              |                                     X                                    |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  68                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 4| 4| 4| 7| 4| 7| 6| 4| 7| 6| 5| 5| 4| 7| 4| 4| 1| 6|              |            |
                             DAY ON TEST   | 3| 5| 7| 3| 3| 3| 7| 2| 0| 7| 3| 9| 7| 5| 7| 3| 7| 7| 7| 8|              |            |
                                           | 0| 3| 0| 6| 0| 0| 0| 9| 5| 0| 0| 6| 0| 7| 0| 0| 0| 0| 5| 0|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |     A      |
    0.5%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |     L      |
    61HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +     +  M        M  +     M  +  +  M     +           +               |  37        |
      Adenoma                              |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +     +  +  +     +  +     +  +  +  +     +           +               |  49        |
      Leukemia Mononuclear                 |                                                          X               |          2 |
      Pars Distalis, Adenoma               |    X                                X  X     X           X               |         26 |
      Pars Distalis, Adenoma, Multiple     |                X                 X                                       |          2 |
      Pars Distalis, Leukemia Mononuclear  |                         X           X                                    |          2 |
      Pars Distalis, Lymphoma Malignant    |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +     +  +  +     +  +     +  +  +  +     +           +               |  48        |
      C-Cell, Adenoma                      |                X                                                         |          6 |
      Follicular Cell, Adenoma             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +     +  +  +     +  +     +  +  +  +     +           +               |  49        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +     +  +  +     +  +     +  +  +  +     +           +               |  49        |
      Adenoma                              | X  X           X     X           X                                       |          7 |
      Leukemia Mononuclear                 |                         X           X                                    |          2 |
      Bilateral, Adenoma                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +     +  +  +     +  +     +  +  +  +     +           +               |  46        |
      Leukemia Mononuclear                 |                                     X                                    |          1 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +     +  +  +     +  +     +  +  +  +     +           +               |  48        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +     +  +  +     +  +     +  +  +  +     +           +               |  49        |
      Leukemia Mononuclear                 |                         X           X                                    |          2 |
      Bilateral, Interstitial Cell, Adenoma| X              X     X  X     X              X           X               |         36 |
      Interstitial Cell, Adenoma           |    X     X                             X                                 |          5 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +     +  +  +     +  +     +  +  +  +     +           +               |  48        |
      Leukemia Mononuclear                 |                         X           X                                    |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +     +  +  +     +  +     +  +  +  +     +           +               |  49        |
      Axillary, Leukemia Mononuclear       |                                                                          |          1 |
      Mediastinal, Leukemia Mononuclear    |                                     X                                    |          6 |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M     +  +  +     +  +     +  +  +  +     +           +               |  46        |
      Leukemia Mononuclear                 |                                     X                                    |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  69                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 4| 4| 4| 7| 4| 7| 6| 4| 7| 6| 5| 5| 4| 7| 4| 4| 1| 6|              |            |
                             DAY ON TEST   | 3| 5| 7| 3| 3| 3| 7| 2| 0| 7| 3| 9| 7| 5| 7| 3| 7| 7| 7| 8|              |            |
                                           | 0| 3| 0| 6| 0| 0| 0| 9| 5| 0| 0| 6| 0| 7| 0| 0| 0| 0| 5| 0|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |     A      |
    0.5%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |     L      |
    61HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +     +  +  +     +  +     +  +  +  +     +           +               |  47        |
      Leukemia Mononuclear                 |                         X           X                                    |          6 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +     +  +  +     +  +     +  +  +  A     +           +               |  48        |
      Leukemia Mononuclear                 |                         X           X                    X               |         16 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +     +  +  +     +  +     +  +  M  +     +           +               |  47        |
      Leukemia Mononuclear                 |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +     +  +  M     M  M     M  +  M  +     +           +               |  26        |
      Adenoma                              |                                              X                           |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +     +  +  +     +  +     +  +  +  +     M           +               |  47        |
      Keratoacanthoma                      |                                                                          |          1 |
      Leukemia Mononuclear                 |                         X           X                                    |          2 |
      Squamous Cell Carcinoma              |          X                                                               |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +     +  +  +     +  +     +  +  +  +     +           +               |  49        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +     +  +  +     +  +     +  +  +  +     +           +               |  49        |
      Astrocytoma Malignant                |                                                                          |          1 |
      Leukemia Mononuclear                 |                         X           X                                    |          3 |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +     +  +  +     +  +     +  +  +  +     +           +               |  49        |
      Adenocarcinoma                       |                                                                          |          1 |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          3 |
      Leukemia Mononuclear                 |                         X           X                    X               |         10 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
      Mediastinum, Adenocarcinoma,         |                                                                          |            |
          Metastatic, Lung                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +     +  +  +     +  +     +  +  +  +     +           +               |  49        |
      Leukemia Mononuclear                 |                         X                                                |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +     +  +  +     +  +     +  +  +  +     +           +               |  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  70                                                               
NTP Experiment-Test: 05057-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                            HC YELLOW 4                                        Date: 04/08/97  
Route: DOSED FEED                                                                                                 Time: 11:18:18  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 4| 4| 4| 7| 4| 7| 6| 4| 7| 6| 5| 5| 4| 7| 4| 4| 1| 6|              |            |
                             DAY ON TEST   | 3| 5| 7| 3| 3| 3| 7| 2| 0| 7| 3| 9| 7| 5| 7| 3| 7| 7| 7| 8|              |            |
                                           | 0| 3| 0| 6| 0| 0| 0| 9| 5| 0| 0| 6| 0| 7| 0| 0| 0| 0| 5| 0|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |     A      |
    0.5%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |     L      |
    61HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Eye                                     | +                       +     +  +           +                           |  12        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +                             +  +           +                           |   6        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +     +  +  +     +  +     +  +  +  +     +           +               |  49        |
      Adenocarcinoma, Metastatic, Lung     |                                                                          |          1 |
      Leukemia Mononuclear                 |                         X           X                    X               |          8 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +     +  +  +     +  +     +  +  +  A     +           +               |  47        |
      Leukemia Mononuclear                 |                                     X                                    |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +     +  +  +     +  +     +  +  +  +     +           +               |  49        |
      Leukemia Mononuclear                 |                         X           X                    X               |         16 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  71                                                               
                                  ------------------------------------------------------------                                      
                                  ----------              END OF REPORT             ----------                                      
                                  ------------------------------------------------------------