TDMS Study 05058-02 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst DATE: 09/08/94
EXP: 05058 ROXARSONE TIME: 14:29:19
TEST: 02 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: C56508
CONT: NOI-ES-28024 CAS: 121-19-7
PATHOLOGIST: D. FARNELL
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
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TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst DATE: 09/08/94
EXP: 05058 ROXARSONE TIME: 14:29:19
TEST: 02 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: C56508
CONT: NOI-ES-28024 CAS: 121-19-7
PATHOLOGIST: D. FARNELL
ROXARSONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = UNTREATD CONTROL |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 23 CENSORED DEATHS 0 TERMINAL 27 |
| |
| UNCENSORED DEATHS |
| 227 299 456 470 535 538 551 618 619 623 |
| 647 653 653 665 666 668 686 701 710 714 |
| 715 715 716 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.01% |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 10 CENSORED DEATHS 0 TERMINAL 40 |
| |
| UNCENSORED DEATHS |
| 117 560 567 645 645 666 678 711 712 714 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.02% |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 17 CENSORED DEATHS 0 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 108 139 432 480 603 603 639 641 653 653 |
| 659 680 680 702 702 710 711 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
ROXARSONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|UNTREATD | 100.0 100.0 98.0 96.0 96.0 92.0 88.0 86.0 72.0 54.0 |
|CONTROL | |
| | |
|0.01% | 100.0 98.0 98.0 98.0 98.0 98.0 98.0 94.0 90.0 80.0 |
| | |
| | |
|0.02% | 100.0 96.0 96.0 96.0 96.0 92.0 92.0 88.0 78.0 66.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| UNTREATD 0.01% 0.02% |
| CONTROL |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 54.0% 80.0% 66.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.248N P=0.009N P=0.319N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 602.0 601.5 576.2 |
|NATURAL DEATHS (C) | (27.5) (56.6) (45.3) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 670.6 703.5 677.0 |
|(STANDARD ERROR) | (15.4) (13.1) (18.3) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
ROXARSONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = UNTREATD CONTROL |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 35 CENSORED DEATHS 1 TERMINAL 14 |
| |
| UNCENSORED DEATHS |
| 170 402 452 466 493 494 494 508 521 524 |
| 527 541 541 547 556 592 621 626 635 638 |
| 647 658 666 667 676 676 684 684 684 688 |
| 710 710 711 716 716 |
| CENSORED DEATHS |
| 42 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.01% |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 32 CENSORED DEATHS 0 TERMINAL 18 |
| |
| UNCENSORED DEATHS |
| 490 492 494 504 504 507 512 518 518 521 |
| 521 522 530 532 532 583 601 612 614 626 |
| 632 634 637 639 650 650 657 658 662 671 |
| 688 707 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.02% |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 33 CENSORED DEATHS 0 TERMINAL 17 |
| |
| UNCENSORED DEATHS |
| 435 477 480 483 485 485 486 501 507 522 |
| 523 527 534 561 561 562 563 581 591 594 |
| 600 601 606 610 610 613 659 676 679 702 |
| 710 714 718 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
ROXARSONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|UNTREATD | 100.0 98.0 98.0 98.0 95.9 91.8 73.5 67.3 55.1 28.6 |
|CONTROL | |
| | |
|0.01% | 100.0 100.0 100.0 100.0 100.0 100.0 70.0 66.0 42.0 36.0 |
| | |
| | |
|0.02% | 100.0 100.0 100.0 100.0 100.0 88.0 74.0 56.0 46.0 34.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| UNTREATD 0.01% 0.02% |
| CONTROL |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 28.6% 36.0% 34.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=1.000N P=0.902N P=1.000N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 589.7 581.8 574.4 |
|NATURAL DEATHS (C) | (19.5) (12.4) (13.8) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 617.8 634.8 627.0 |
|(STANDARD ERROR) | (20.1) (12.8) (13.8) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
ROXARSONE
KAPLAN-MEIER SURVIVAL CURVES
UNTREATD CONTROL = 1
0.01% = 2
0.02% = 3
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 32 1
|
| 32 3 1 1 2
| 3 1 3 1 22
95 +
| 3 1 13 2 2
| 13 1 3
|
90 + 2 2
|
| 1 1 3 3 22
| 1 1 2 2
P 85 +
E | 3 3
R |
C |
E 80 + 1 13 3 2 2
N |
T | 11 3 3
|
S 75 +
U | 1 1 3 3
R | 11
V |
I 70 + 33
V |
A | 1 1
L | 1 13 3
65 +
| 11
|
|
60 + 11
|
|
|
55 +
| 1 1
|
|
50 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 2 obs hidden.
ROXARSONE
KAPLAN-MEIER SURVIVAL CURVES
UNTREATD CONTROL = 1
0.01% = 2
0.02% = 3
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 3 2
| 1 1 3 322
| 1 1 1 22
| 1 331
90 + 22
| 22
| 3131
| 12 1
P 80 + 11
E | 31 1
R | 223 3
C | 111
E 70 + 2 1 2 1
N | 2 12 1
T | 3 3 32 211
| 2 11
S 60 + 33 2111
U | 11
R | 333 22 1 1
V | 22
I 50 + 11
V | 3 22 3 11
A | 2 2 3
L | 223 3
40 + 2 11 31
| 2 2
| 233 2
| 11
30 +
| 1 1
|
|
20 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 23 obs hidden.
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