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TDMS Study 05069-08 Pathology Tables

                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE


NTP Experiment-Test: 05069-08                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 03/13/95
Route: DERMAL,SOLUTION                                                                                            Time: 17:45:22


                                                          66 WEEK SSAC


       Facility:  TSI Mason Research

       Chemical CAS #:  147-47-7

       Lock Date:  08/21/92

       Cage Range:  All

       Reasons For Removal:    25017 Scheduled Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include All































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1
NTP Experiment-Test: 05069-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 17:45:22  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 MG/KG      36 MG/KG     60 MG/KG     100                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
  Animals Examined Microscopically                    10           10           10           10                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Jejunum                           (10)         (10)         (10)         (10)                                   
      Inflammation, Chronic Active                     1 (10%)                                                                      
   Intestine Small, Ileum                             (10)         (10)         (10)         (10)                                   
      Dilatation                                                    1 (10%)                                                         
      Erosion                                                       1 (10%)                                                         
   Liver                                              (10)         (10)         (10)         (10)                                   
      Basophilic Focus                                 9 (90%)      9 (90%)      9 (90%)      7 (70%)                               
      Clear Cell Focus                                 1 (10%)                   2 (20%)                                            
      Cyst                                                                                    1 (10%)                               
      Eosinophilic Focus                                                         1 (10%)                                            
      Fatty Change, Focal                                           1 (10%)                   2 (20%)                               
      Hepatodiaphragmatic Nodule                       1 (10%)      4 (40%)      1 (10%)      3 (30%)                               
      Mixed Cell Focus                                 2 (20%)      1 (10%)                                                         
   Mesentery                                          (1)          (1)                       (1)                                    
      Fat, Necrosis                                    1 (100%)     1 (100%)                  1 (100%)                              
   Pancreas                                           (10)         (10)         (10)         (10)                                   
      Acinus, Atrophy                                  3 (30%)      6 (60%)      6 (60%)      4 (40%)                               
      Artery, Inflammation, Chronic Active                                       1 (10%)                                            
   Salivary Glands                                    (10)         (10)         (10)         (10)                                   
      Duct, Metaplasia, Squamous                       1 (10%)      3 (30%)      1 (10%)      3 (30%)                               
   Stomach, Forestomach                               (10)         (10)         (10)         (10)                                   
      Hyperkeratosis                                                                          1 (10%)                               
      Hyperplasia, Basal Cell                                                                 1 (10%)                               
      Inflammation, Acute                                                                     1 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (10)         (10)         (10)         (10)                                   
      Cardiomyopathy                                   5 (50%)      7 (70%)      7 (70%)      8 (80%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05069-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 17:45:22  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 MG/KG      36 MG/KG     60 MG/KG     100                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)         (10)         (10)         (10)                                   
      Hyperplasia                                                                1 (10%)                                            
   Adrenal Medulla                                    (10)         (10)         (10)         (10)                                   
      Hyperplasia                                      1 (10%)                                                                      
   Pituitary Gland                                    (10)         (10)         (10)         (10)                                   
      Pars Distalis, Angiectasis                       3 (30%)      4 (40%)      6 (60%)      6 (60%)                               
      Pars Distalis, Cyst                              6 (60%)      8 (80%)      8 (80%)      7 (70%)                               
      Pars Distalis, Hyperplasia                       3 (30%)      6 (60%)      6 (60%)      5 (50%)                               
   Thyroid Gland                                      (10)         (10)         (10)         (10)                                   
      C-Cell, Hyperplasia                              1 (10%)                                                                      
      Follicle, Cyst                                   2 (20%)                                                                      
      Follicular Cell, Hyperplasia                                  1 (10%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (10)         (10)         (10)         (10)                                   
      Cyst                                             1 (10%)                   2 (20%)      1 (10%)                               
   Uterus                                             (10)         (10)         (10)         (10)                                   
      Cyst                                             1 (10%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (10)         (10)         (10)         (10)                                   
      Inflammation, Chronic                            3 (30%)                   1 (10%)      1 (10%)                               
      Skin, Site of Application, Acanthosis            1 (10%)      4 (40%)      4 (40%)      8 (80%)                               
      Skin, Site of Application, Hyperkeratosis        1 (10%)                   1 (10%)      1 (10%)                               
      Skin, Site of Application, Inflammation,                                                                                      
           Chronic                                     1 (10%)      1 (10%)                                                         
      Subcutaneous Tissue, Inflammation, Chronic                                                                                    
          Active                                                    1 (10%)                                                         
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05069-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 17:45:22  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 MG/KG      36 MG/KG     60 MG/KG     100                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)         (10)         (10)         (10)                                   
      Foreign Body                                                               1 (10%)                                            
      Infiltration Cellular, Histiocyte                             2 (20%)      4 (40%)      3 (30%)                               
      Inflammation, Chronic Active                                               1 (10%)                                            
      Alveolar Epithelium, Hyperplasia                                           1 (10%)                                            
   Nose                                               (10)         (10)         (10)         (10)                                   
      Fungus                                           1 (10%)                                                                      
      Inflammation, Acute                              1 (10%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                             (1)                                                              
      Lens, Cataract                                                1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)         (10)         (10)         (10)                                   
      Nephropathy, Chronic                             9 (90%)     10 (100%)    10 (100%)    10 (100%)                              
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05069-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 17:45:22  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 MG/KG      36 MG/KG     60 MG/KG     100                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
  Animals Examined Microscopically                    10           10           10           10                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Ileum                             (10)         (10)         (10)         (10)                                   
      Erosion                                                                    1 (10%)      1 (10%)                               
      Inflammation, Chronic Active                                                            1 (10%)                               
      Ulcer                                                                                   1 (10%)                               
   Liver                                              (10)         (10)         (10)         (10)                                   
      Basophilic Focus                                 4 (40%)                                                                      
      Clear Cell Focus                                 3 (30%)      2 (20%)                                                         
      Eosinophilic Focus                               1 (10%)                                                                      
      Fatty Change, Focal                             10 (100%)     9 (90%)      8 (80%)     10 (100%)                              
      Hepatodiaphragmatic Nodule                                    2 (20%)                   1 (10%)                               
      Necrosis                                                                   1 (10%)                                            
   Mesentery                                          (1)                                    (1)                                    
      Fat, Inflammation, Chronic Active                1 (100%)                                                                     
      Fat, Necrosis                                                                           1 (100%)                              
   Pancreas                                           (10)         (10)         (10)         (10)                                   
      Pigmentation                                     1 (10%)                                                                      
      Acinus, Atrophy                                  3 (30%)      5 (50%)      6 (60%)      7 (70%)                               
   Salivary Glands                                    (10)         (10)         (10)         (10)                                   
      Duct, Metaplasia, Squamous                       2 (20%)      3 (30%)      2 (20%)      4 (40%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (10)         (10)         (10)         (10)                                   
      Cardiomyopathy                                  10 (100%)    10 (100%)     9 (90%)     10 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)         (10)         (10)         (10)                                   
      Hyperplasia                                                   1 (10%)                                                         
   Adrenal Medulla                                    (10)         (10)         (10)         (10)                                   
      Hyperplasia                                      1 (10%)                   2 (20%)                                            
   Islets, Pancreatic                                 (10)         (10)         (10)         (10)                                   
      Hyperplasia                                                                1 (10%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05069-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 17:45:22  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 MG/KG      36 MG/KG     60 MG/KG     100                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
   Pituitary Gland                                    (9)          (10)         (10)         (9)                                    
      Pars Distalis, Angiectasis                       3 (33%)                   2 (20%)      2 (22%)                               
      Pars Distalis, Cyst                              1 (11%)      1 (10%)      3 (30%)                                            
      Pars Distalis, Hyperplasia                       6 (67%)      2 (20%)      2 (20%)      2 (22%)                               
      Pars Intermedia, Cyst                                                      2 (20%)      1 (11%)                               
   Thyroid Gland                                      (10)         (10)         (10)         (10)                                   
      C-Cell, Hyperplasia                                                                     1 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Testes                                             (10)         (10)         (10)         (10)                                   
      Interstitial Cell, Hyperplasia                   9 (90%)      5 (50%)      4 (40%)      8 (80%)                               
      Seminiferous Tubule, Atrophy                     2 (20%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                                                                (1)                                    
      Pancreatic, Hyperplasia                                                                 1 (100%)                              
   Lymph Node, Mesenteric                             (10)         (10)         (10)         (10)                                   
      Ectasia                                                                    1 (10%)      1 (10%)                               
   Spleen                                             (10)         (10)         (10)         (10)                                   
      Fibrosis                                                                   1 (10%)      1 (10%)                               
      Capsule, Pigmentation                            1 (10%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (10)         (10)         (10)         (10)                                   
      Inflammation, Chronic                                         1 (10%)      1 (10%)                                            
      Skin, Site of Application, Acanthosis            1 (10%)     10 (100%)     9 (90%)      9 (90%)                               
      Skin, Site of Application, Inflammation,                                                                                      
           Chronic                                     2 (20%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05069-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 03/13/95  
Route: DERMAL,SOLUTION                                                                                            Time: 17:45:22  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 MG/KG      36 MG/KG     60 MG/KG     100                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)         (10)         (9)          (10)                                   
      Edema                                                         1 (10%)                                                         
      Hemorrhage                                       1 (10%)      4 (40%)                   1 (10%)                               
      Infiltration Cellular, Histiocyte                2 (20%)      3 (30%)      1 (11%)                                            
   Nose                                               (10)         (9)          (10)         (10)                                   
      Fungus                                           2 (20%)                   1 (10%)                                            
      Inflammation, Chronic Active                     4 (40%)      3 (33%)      1 (10%)      1 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)         (10)         (10)         (10)                                   
      Cyst                                             1 (10%)                   1 (10%)                                            
      Nephropathy, Chronic                            10 (100%)    10 (100%)    10 (100%)    10 (100%)                              
   Urinary Bladder                                    (10)         (10)         (10)         (10)                                   
      Calculus Gross Observation                       1 (10%)      1 (10%)                   2 (20%)                               
      Calculus Micro Observation Only                  1 (10%)      1 (10%)                   2 (20%)                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------