TDMS Study 05070-01 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Midwest Research Inst VINYL TOLUENE DATE: 09/08/94
EXPERIMENT: 05070 TEST: 01 TIME: 22:47:44
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-38042 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 56406
PATHOLOGIST: M. STEDHAM CAS: 25013154
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Midwest Research Inst VINYL TOLUENE DATE: 09/08/94
EXPERIMENT: 05070 TEST: 01 TIME: 22:47:44
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-38042 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 56406
PATHOLOGIST: M. STEDHAM CAS: 25013154
RATS(FISCHER344)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Bone Marrow
Brain
Clitoral Gland
Epididymis
Heart
Islets, Pancreatic
Kidney
Larynx
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Midwest Research Inst VINYL TOLUENE DATE: 09/08/94
EXPERIMENT: 05070 TEST: 01 TIME: 22:47:44
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-38042 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 56406
PATHOLOGIST: M. STEDHAM CAS: 25013154
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF VINYL TOLUENE
====================================================================================================
MALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Adrenal Medulla Pheochromocytoma Malignant
Thyroid Gland: Follicular Cell
Carcinoma
Carcinoma or Adenoma
All Organs Malignant Tumors
====================================================================================================
FEMALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Clitoral/Preputial Gland Carcinoma
Carcinoma or Adenoma
Mammary Gland Fibroadenoma
All Organs Benign Tumors
Malignant and Benign Tumors
====================================================================================================
DATE: 09/09/94 EXPERIMENT: 05070 TEST: 01 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- VINYL TOLUENE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 100 PPM 300 PPM | CONTROL 100 PPM 300 PPM |
| | | |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/49 (4%) 0/20 (0%) 0/50 (0%) | 1/50 (2%) 0/14 (0%) 0/50 (0%) |
|ADJUSTED (b) | 10.5% 0.0% 0.0% | 2.9% 0.0% 0.0% |
|TERMINAL (d) | 2/19 (11%) 0/6 (0%) 0/19 (0%) | 0/31 (0%) 0/4 (0%) 0/26 (0%) |
|FIRST INCIDENCE (DAYS) | 728 (T) --- --- | 708 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.171N P=0.513N P=0.237N | P=0.412N P=0.525N P=0.525N |
|INCIDENTAL TUMOR | P=0.171N P=0.513N P=0.237N | P=0.333N P=0.892N P=0.455N |
|LOGISTIC REGRESSION | P=0.171N P=0.513N P=0.237N | P=0.389N P=0.860N P=0.515N |
|COCHRAN-ARMITAGE | P=0.169N | P=0.378N |
|FISHER EXACT | P=0.501N P=0.242N | P=0.781N P=0.500N |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 14/49 (29%) 6/21 (29%) 14/46 (30%) | 5/48 (10%) 0/14 (0%) 3/45 (7%) |
|ADJUSTED (b) | 51.1% 35.4% 58.2% | 14.6% 0.0% 9.7% |
|TERMINAL (d) | 7/19 (37%) 2/7 (29%) 9/18 (50%) | 3/31 (10%) 0/4 (0%) 1/23 (4%) |
|FIRST INCIDENCE (DAYS) | 623 393 541 | 683 --- 456 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.515 P=0.246N P=0.563N | P=0.483N P=0.177N P=0.472N |
|INCIDENTAL TUMOR | P=0.525 P=0.516 P=0.553 | P=0.324N P=0.446N P=0.329N |
|LOGISTIC REGRESSION | P=0.558 P=0.528 P=0.590N | P=0.399N P=0.404N P=0.404N |
|COCHRAN-ARMITAGE | P=0.476 | P=0.383N |
|FISHER EXACT | P=0.619N P=0.510 | P=0.265N P=0.394N |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05070 TEST: 01 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- VINYL TOLUENE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 100 PPM 300 PPM | CONTROL 100 PPM 300 PPM |
| | | |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Complex |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/49 (6%) 0/21 (0%) 1/46 (2%) | 0/48 (0%) 0/14 (0%) 0/45 (0%) |
|ADJUSTED (b) | 12.0% 0.0% 5.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/19 (5%) 0/7 (0%) 0/18 (0%) | 0/31 (0%) 0/4 (0%) 0/23 (0%) |
|FIRST INCIDENCE (DAYS) | 621 --- 724 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.279N P=0.193N P=0.297N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.237N P=0.391N P=0.279N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.266N P=0.349N P=0.305N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.291N | (e) |
|FISHER EXACT | P=0.337N P=0.333N | (e) (e) |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Malignant |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/49 (2%) 3/21 (14%) 2/46 (4%) | 2/48 (4%) 0/14 (0%) 1/45 (2%) |
|ADJUSTED (b) | 5.3% 30.9% 9.5% | 5.0% 0.0% 3.1% |
|TERMINAL (d) | 1/19 (5%) 2/7 (29%) 1/18 (6%) | 0/31 (0%) 0/4 (0%) 0/23 (0%) |
|FIRST INCIDENCE (DAYS) | 728 (T) 637 701 | 545 --- 690 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.550 P=0.090 P=0.503 | P=0.529N P=0.256N P=0.535N |
|INCIDENTAL TUMOR | P=0.555 P=0.049 * P=0.526 | P=0.323N P=0.371N P=0.346N |
|LOGISTIC REGRESSION | P=0.576 P=0.034 * P=0.507 | P=0.466N P=0.488N P=0.512N |
|COCHRAN-ARMITAGE | P=0.527 | P=0.471N |
|FISHER EXACT | P=0.078 P=0.476 | P=0.597N P=0.524N |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05070 TEST: 01 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- VINYL TOLUENE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 100 PPM 300 PPM | CONTROL 100 PPM 300 PPM |
| | | |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma: Benign, Complex, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 17/49 (35%) 8/21 (38%) 15/46 (33%) | 7/48 (15%) 0/14 (0%) 4/45 (9%) |
|ADJUSTED (b) | 60.4% 50.0% 60.0% | 18.9% 0.0% 12.5% |
|TERMINAL (d) | 9/19 (47%) 3/7 (43%) 9/18 (50%) | 3/31 (10%) 0/4 (0%) 1/23 (4%) |
|FIRST INCIDENCE (DAYS) | 621 393 541 | 545 --- 456 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.410N P=0.292N P=0.393N | P=0.408N P=0.058N P=0.375N |
|INCIDENTAL TUMOR | P=0.403N P=0.369 P=0.452N | P=0.187N P=0.183N P=0.170N |
|LOGISTIC REGRESSION | P=0.355N P=0.362 P=0.404N | P=0.308N P=0.186N P=0.299N |
|COCHRAN-ARMITAGE | P=0.453N | P=0.300N |
|FISHER EXACT | P=0.496 P=0.501N | P=0.150N P=0.300N |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/46 (2%) 0/18 (0%) 2/48 (4%) | 1/48 (2%) 2/11 (18%) 2/46 (4%) |
|ADJUSTED (b) | 2.4% 0.0% 10.5% | 2.8% 27.0% 6.7% |
|TERMINAL (d) | 0/19 (0%) 0/5 (0%) 2/19 (11%) | 0/31 (0%) 1/4 (25%) 1/25 (4%) |
|FIRST INCIDENCE (DAYS) | 532 --- 728 (T) | 688 661 680 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.378 P=0.486N P=0.513 | P=0.432 P=0.309 P=0.455 |
|INCIDENTAL TUMOR | P=0.350 P=0.450N P=0.482 | P=0.588 P=0.069 P=0.558 |
|LOGISTIC REGRESSION | P=0.401 P=0.553N P=0.516 | P=0.505 P=0.053 P=0.477 |
|COCHRAN-ARMITAGE | P=0.390 | P=0.512 |
|FISHER EXACT | P=0.719N P=0.516 | P=0.086 P=0.484 |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05070 TEST: 01 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- VINYL TOLUENE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 100 PPM 300 PPM | CONTROL 100 PPM 300 PPM |
| | | |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/46 (2%) 2/18 (11%) 1/48 (2%) | 0/48 (0%) 2/11 (18%) 0/46 (0%) |
|ADJUSTED (b) | 5.3% 40.0% 3.4% | 0.0% 50.0% 0.0% |
|TERMINAL (d) | 1/19 (5%) 2/5 (40%) 0/19 (0%) | 0/31 (0%) 2/4 (50%) 0/25 (0%) |
|FIRST INCIDENCE (DAYS) | 728 (T) 728 (T) 669 | --- 728 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.542N P=0.096 P=0.748N | P=0.572N P=0.002 ** (e) |
|INCIDENTAL TUMOR | P=0.476N P=0.096 P=0.705N | P=0.572N P=0.002 ** (e) |
|LOGISTIC REGRESSION | P=0.491N P=0.096 P=0.744N | P=0.572N P=0.002 ** (e) |
|COCHRAN-ARMITAGE | P=0.531N | P=0.532N |
|FISHER EXACT | P=0.189 P=0.742N | P=0.032 * (e) |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/46 (4%) 2/18 (11%) 3/48 (6%) | 1/48 (2%) 4/11 (36%) 2/46 (4%) |
|ADJUSTED (b) | 7.6% 40.0% 13.6% | 2.8% 75.7% 6.7% |
|TERMINAL (d) | 1/19 (5%) 2/5 (40%) 2/19 (11%) | 0/31 (0%) 3/4 (75%) 1/25 (4%) |
|FIRST INCIDENCE (DAYS) | 532 728 (T) 669 | 688 661 680 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.499 P=0.335 P=0.520 | P=0.515 P=0.007 ** P=0.455 |
|INCIDENTAL TUMOR | P=0.531 P=0.354 P=0.532 | P=0.574N P<0.001 ** P=0.558 |
|LOGISTIC REGRESSION | P=0.555 P=0.208 P=0.530 | P=0.586 P<0.001 ** P=0.477 |
|COCHRAN-ARMITAGE | P=0.514 | P=0.601 |
|FISHER EXACT | P=0.313 P=0.520 | P=0.003 ** P=0.484 |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05070 TEST: 01 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- VINYL TOLUENE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 100 PPM 300 PPM | CONTROL 100 PPM 300 PPM |
| | | |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 6/46 (13%) 3/16 (19%) 5/49 (10%) | 1/50 (2%) 0/12 (0%) 1/49 (2%) |
|ADJUSTED (b) | 27.9% 52.6% 21.6% | 3.2% 0.0% 2.9% |
|TERMINAL (d) | 4/19 (21%) 2/4 (50%) 2/19 (11%) | 1/31 (3%) 0/3 (0%) 0/26 (0%) |
|FIRST INCIDENCE (DAYS) | 697 700 700 | 728 (T) --- 680 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.413N P=0.478 P=0.470N | P=0.634 P=0.927N P=0.735 |
|INCIDENTAL TUMOR | P=0.264N P=0.170 P=0.371N | P=0.681N P=0.927N P=0.756N |
|LOGISTIC REGRESSION | P=0.333N P=0.174 P=0.445N | P=0.658 P=0.927N P=0.748 |
|COCHRAN-ARMITAGE | P=0.375N | P=0.668 |
|FISHER EXACT | P=0.423 P=0.455N | P=0.806N P=0.747 |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/46 (0%) 0/16 (0%) 1/49 (2%) | 1/50 (2%) 1/12 (8%) 2/49 (4%) |
|ADJUSTED (b) | 0.0% 0.0% 5.3% | 3.2% 33.3% 6.9% |
|TERMINAL (d) | 0/19 (0%) 0/4 (0%) 1/19 (5%) | 1/31 (3%) 1/3 (33%) 1/26 (4%) |
|FIRST INCIDENCE (DAYS) | --- --- 728 (T) | 728 (T) 728 (T) 697 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.351 (e) P=0.500 | P=0.403 P=0.206 P=0.445 |
|INCIDENTAL TUMOR | P=0.351 (e) P=0.500 | P=0.461 P=0.206 P=0.485 |
|LOGISTIC REGRESSION | P=0.351 (e) P=0.500 | P=0.441 P=0.206 P=0.464 |
|COCHRAN-ARMITAGE | P=0.351 | P=0.462 |
|FISHER EXACT | (e) P=0.516 | P=0.352 P=0.492 |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05070 TEST: 01 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- VINYL TOLUENE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 100 PPM 300 PPM | CONTROL 100 PPM 300 PPM |
| | | |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 6/46 (13%) 3/16 (19%) 5/49 (10%) | 2/50 (4%) 1/12 (8%) 3/49 (6%) |
|ADJUSTED (b) | 27.9% 52.6% 21.6% | 6.5% 33.3% 9.6% |
|TERMINAL (d) | 4/19 (21%) 2/4 (50%) 2/19 (11%) | 2/31 (6%) 1/3 (33%) 1/26 (4%) |
|FIRST INCIDENCE (DAYS) | 697 700 700 | 728 (T) 728 (T) 680 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.413N P=0.478 P=0.470N | P=0.379 P=0.311 P=0.437 |
|INCIDENTAL TUMOR | P=0.264N P=0.170 P=0.371N | P=0.470 P=0.311 P=0.492 |
|LOGISTIC REGRESSION | P=0.333N P=0.174 P=0.445N | P=0.432 P=0.311 P=0.460 |
|COCHRAN-ARMITAGE | P=0.375N | P=0.452 |
|FISHER EXACT | P=0.423 P=0.455N | P=0.482 P=0.490 |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Lipoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/49 (0%) 0/35 (0%) 2/50 (4%) | 0/50 (0%) 0/14 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 7.7% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/19 (0%) 0/9 (0%) 1/19 (5%) | 0/31 (0%) 0/2 (0%) 0/26 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 611 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.115 (e) P=0.249 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.102 (e) P=0.218 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.118 (e) P=0.247 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.112 | (e) |
|FISHER EXACT | (e) P=0.253 | (e) (e) |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05070 TEST: 01 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- VINYL TOLUENE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 100 PPM 300 PPM | CONTROL 100 PPM 300 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/49 (4%) 2/42 (5%) 1/50 (2%) | 0/50 (0%) 0/33 (0%) 0/50 (0%) |
|ADJUSTED (b) | 10.5% 11.1% 5.3% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 2/19 (11%) 1/12 (8%) 1/19 (5%) | 0/31 (0%) 0/13 (0%) 0/26 (0%) |
|FIRST INCIDENCE (DAYS) | 728 (T) 627 728 (T) | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.372N P=0.570 P=0.500N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.396N P=0.567 P=0.500N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.350N P=0.588 P=0.500N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.387N | (e) |
|FISHER EXACT | P=0.631 P=0.492N | (e) (e) |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/49 (0%) 1/50 (2%) 1/50 (2%) | 3/50 (6%) 1/50 (2%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 5.9% 5.3% | 9.0% 2.2% 6.1% |
|TERMINAL (d) | 0/19 (0%) 1/17 (6%) 1/19 (5%) | 2/31 (6%) 0/28 (0%) 1/26 (4%) |
|FIRST INCIDENCE (DAYS) | --- 728 (T) 728 (T) | 683 560 576 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.431 P=0.478 P=0.500 | P=0.548N P=0.328N P=0.562N |
|INCIDENTAL TUMOR | P=0.431 P=0.478 P=0.500 | P=0.524N P=0.297N P=0.527N |
|LOGISTIC REGRESSION | P=0.431 P=0.478 P=0.500 | P=0.494N P=0.306N P=0.512N |
|COCHRAN-ARMITAGE | P=0.429 | P=0.500N |
|FISHER EXACT | P=0.505 P=0.505 | P=0.309N P=0.500N |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05070 TEST: 01 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- VINYL TOLUENE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 100 PPM 300 PPM | CONTROL 100 PPM 300 PPM |
| | | |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/49 (0%) 1/50 (2%) 1/50 (2%) | 3/50 (6%) 2/50 (4%) 3/50 (6%) |
|ADJUSTED (b) | 0.0% 5.9% 5.3% | 9.0% 5.7% 8.0% |
|TERMINAL (d) | 0/19 (0%) 1/17 (6%) 1/19 (5%) | 2/31 (6%) 1/28 (4%) 1/26 (4%) |
|FIRST INCIDENCE (DAYS) | --- 728 (T) 728 (T) | 683 560 434 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.431 P=0.478 P=0.500 | P=0.525 P=0.530N P=0.607 |
|INCIDENTAL TUMOR | P=0.431 P=0.478 P=0.500 | P=0.598 P=0.499N P=0.624N |
|LOGISTIC REGRESSION | P=0.431 P=0.478 P=0.500 | P=0.592 P=0.499N P=0.654N |
|COCHRAN-ARMITAGE | P=0.429 | P=0.577 |
|FISHER EXACT | P=0.505 P=0.505 | P=0.500N P=0.661N |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroadenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/49 (2%) 0/50 (0%) 1/50 (2%) | 16/50 (32%) 8/50 (16%) 9/50 (18%) |
|ADJUSTED (b) | 3.7% 0.0% 4.3% | 42.3% 25.6% 26.4% |
|TERMINAL (d) | 0/19 (0%) 0/17 (0%) 0/19 (0%) | 10/31 (32%) 6/28 (21%) 4/26 (15%) |
|FIRST INCIDENCE (DAYS) | 658 --- 704 | 592 583 499 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.676 P=0.479N P=0.731N | P=0.197N P=0.090N P=0.181N |
|INCIDENTAL TUMOR | P=0.690N P=0.448N P=0.655N | P=0.126N P=0.055N P=0.093N |
|LOGISTIC REGRESSION | P=0.663 P=0.496N P=0.748N | P=0.121N P=0.050N* P=0.096N |
|COCHRAN-ARMITAGE | P=0.652 | P=0.103N |
|FISHER EXACT | P=0.495N P=0.747N | P=0.050N P=0.083N |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05070 TEST: 01 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- VINYL TOLUENE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 100 PPM 300 PPM | CONTROL 100 PPM 300 PPM |
| | | |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/49 (2%) 0/50 (0%) 1/50 (2%) | 16/50 (32%) 9/50 (18%) 10/50 (20%) |
|ADJUSTED (b) | 3.7% 0.0% 4.3% | 42.3% 29.0% 27.9% |
|TERMINAL (d) | 0/19 (0%) 0/17 (0%) 0/19 (0%) | 10/31 (32%) 7/28 (25%) 4/26 (15%) |
|FIRST INCIDENCE (DAYS) | 658 --- 704 | 592 583 434 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.676 P=0.479N P=0.731N | P=0.268N P=0.137N P=0.248N |
|INCIDENTAL TUMOR | P=0.690N P=0.448N P=0.655N | P=0.167N P=0.091N P=0.122N |
|LOGISTIC REGRESSION | P=0.663 P=0.496N P=0.748N | P=0.166N P=0.082N P=0.134N |
|COCHRAN-ARMITAGE | P=0.652 | P=0.151N |
|FISHER EXACT | P=0.495N P=0.747N | P=0.083N P=0.127N |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma, Carcinoma, or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/49 (2%) 1/50 (2%) 2/50 (4%) | 18/50 (36%) 10/50 (20%) 12/50 (24%) |
|ADJUSTED (b) | 3.7% 5.9% 9.4% | 47.8% 30.6% 32.8% |
|TERMINAL (d) | 0/19 (0%) 1/17 (6%) 1/19 (5%) | 12/31 (39%) 7/28 (25%) 5/26 (19%) |
|FIRST INCIDENCE (DAYS) | 658 728 (T) 704 | 592 560 434 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.423 P=0.760 P=0.530 | P=0.309N P=0.107N P=0.277N |
|INCIDENTAL TUMOR | P=0.471 P=0.745N P=0.608 | P=0.200N P=0.067N P=0.144N |
|LOGISTIC REGRESSION | P=0.426 P=0.762N P=0.530 | P=0.187N P=0.058N P=0.147N |
|COCHRAN-ARMITAGE | P=0.399 | P=0.174N |
|FISHER EXACT | P=0.747N P=0.508 | P=0.059N P=0.138N |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05070 TEST: 01 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- VINYL TOLUENE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 100 PPM 300 PPM | CONTROL 100 PPM 300 PPM |
| | | |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 31/49 (63%) 21/35 (60%) 30/50 (60%) | 28/50 (56%) 26/43 (60%) 29/50 (58%) |
|ADJUSTED (b) | 92.9% 78.9% 80.0% | 71.1% 73.7% 71.2% |
|TERMINAL (d) | 17/19 (89%) 8/12 (67%) 12/19 (63%) | 20/31 (65%) 14/22 (64%) 15/26 (58%) |
|FIRST INCIDENCE (DAYS) | 506 499 512 | 545 495 414 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.431N P=0.270N P=0.395N | P=0.247 P=0.302 P=0.252 |
|INCIDENTAL TUMOR | P=0.396N P=0.562 P=0.427N | P=0.435 P=0.385 P=0.438 |
|LOGISTIC REGRESSION | P=0.354N P=0.481N P=0.375N | P=0.431 P=0.371 P=0.440 |
|COCHRAN-ARMITAGE | P=0.435N | P=0.501 |
|FISHER EXACT | P=0.469N P=0.449N | P=0.412 P=0.500 |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/49 (6%) 1/35 (3%) 1/50 (2%) | 4/50 (8%) 2/43 (5%) 1/50 (2%) |
|ADJUSTED (b) | 11.9% 4.5% 5.3% | 12.1% 9.1% 2.3% |
|TERMINAL (d) | 1/19 (5%) 0/12 (0%) 1/19 (5%) | 3/31 (10%) 2/22 (9%) 0/26 (0%) |
|FIRST INCIDENCE (DAYS) | 599 695 728 (T) | 683 728 (T) 576 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.252N P=0.369N P=0.294N | P=0.188N P=0.477N P=0.226N |
|INCIDENTAL TUMOR | P=0.221N P=0.416N P=0.283N | P=0.174N P=0.455N P=0.201N |
|LOGISTIC REGRESSION | P=0.234N P=0.434N P=0.277N | P=0.160N P=0.456N P=0.186N |
|COCHRAN-ARMITAGE | P=0.254N | P=0.147N |
|FISHER EXACT | P=0.444N P=0.301N | P=0.413N P=0.181N |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05070 TEST: 01 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- VINYL TOLUENE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 100 PPM 300 PPM | CONTROL 100 PPM 300 PPM |
| | | |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 33/49 (67%) 22/35 (63%) 30/50 (60%) | 32/50 (64%) 28/43 (65%) 30/50 (60%) |
|ADJUSTED (b) | 93.4% 79.8% 80.0% | 79.5% 80.3% 71.9% |
|TERMINAL (d) | 17/19 (89%) 8/12 (67%) 12/19 (63%) | 23/31 (74%) 16/22 (73%) 15/26 (58%) |
|FIRST INCIDENCE (DAYS) | 506 499 512 | 545 495 414 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.310N P=0.231N P=0.280N | P=0.401 P=0.374 P=0.413 |
|INCIDENTAL TUMOR | P=0.227N P=0.569N P=0.262N | P=0.451N P=0.490 P=0.492N |
|LOGISTIC REGRESSION | P=0.203N P=0.435N P=0.226N | P=0.444N P=0.489 P=0.481N |
|COCHRAN-ARMITAGE | P=0.276N | P=0.369N |
|FISHER EXACT | P=0.422N P=0.291N | P=0.542 P=0.418N |
|=================================================================================================================================|
| |
|Skin |
| Keratoacanthoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/49 (4%) 4/50 (8%) 5/50 (10%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 8.3% 17.7% 20.6% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/19 (5%) 2/17 (12%) 3/19 (16%) | 0/31 (0%) 0/28 (0%) 0/26 (0%) |
|FIRST INCIDENCE (DAYS) | 638 479 589 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.235 P=0.307 P=0.241 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.210 P=0.334 P=0.220 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.228 P=0.345 P=0.246 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.208 | (e) |
|FISHER EXACT | P=0.349 P=0.226 | (e) (e) |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05070 TEST: 01 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- VINYL TOLUENE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 100 PPM 300 PPM | CONTROL 100 PPM 300 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/49 (2%) 0/50 (0%) 1/50 (2%) | 2/50 (4%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 2.2% 0.0% 5.3% | 5.9% 0.0% 0.0% |
|TERMINAL (d) | 0/19 (0%) 0/17 (0%) 1/19 (5%) | 1/31 (3%) 0/28 (0%) 0/26 (0%) |
|FIRST INCIDENCE (DAYS) | 506 --- 728 (T) | 688 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.658 P=0.504N P=0.751N | P=0.192N P=0.251N P=0.273N |
|INCIDENTAL TUMOR | P=0.608 P=0.500N P=0.716 | P=0.169N P=0.215N P=0.234N |
|LOGISTIC REGRESSION | P=0.631 P=0.519N P=0.744 | P=0.180N P=0.239N P=0.253N |
|COCHRAN-ARMITAGE | P=0.652 | P=0.171N |
|FISHER EXACT | P=0.495N P=0.747N | P=0.247N P=0.247N |
|=================================================================================================================================|
| |
|Skin |
| Trichoepithelioma, Kertatocanthoma, Squamous Cell Carcinoma, |
| Basal Cell Carcinoma or Adenoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 3/49 (6%) 4/50 (8%) 7/50 (14%) | 2/50 (4%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 10.3% 17.7% 27.6% | 5.9% 0.0% 3.8% |
|TERMINAL (d) | 1/19 (5%) 2/17 (12%) 4/19 (21%) | 1/31 (3%) 0/28 (0%) 1/26 (4%) |
|FIRST INCIDENCE (DAYS) | 506 479 589 | 688 --- 728 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.146 P=0.465 P=0.187 | P=0.544N P=0.251N P=0.554N |
|INCIDENTAL TUMOR | P=0.107 P=0.494 P=0.138 | P=0.517N P=0.215N P=0.515N |
|LOGISTIC REGRESSION | P=0.128 P=0.511 P=0.174 | P=0.528N P=0.239N P=0.533N |
|COCHRAN-ARMITAGE | P=0.120 | P=0.500N |
|FISHER EXACT | P=0.511 P=0.167 | P=0.247N P=0.500N |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05070 TEST: 01 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- VINYL TOLUENE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 100 PPM 300 PPM | CONTROL 100 PPM 300 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/49 (4%) 1/50 (2%) 1/50 (2%) | 3/50 (6%) 2/50 (4%) 1/50 (2%) |
|ADJUSTED (b) | 7.8% 4.3% 3.1% | 7.2% 5.9% 3.1% |
|TERMINAL (d) | 1/19 (5%) 0/17 (0%) 0/19 (0%) | 0/31 (0%) 1/28 (4%) 0/26 (0%) |
|FIRST INCIDENCE (DAYS) | 599 694 660 | 434 637 690 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.416N P=0.516N P=0.473N | P=0.286N P=0.518N P=0.338N |
|INCIDENTAL TUMOR | P=0.389N P=0.483N P=0.470N | P=0.199N P=0.455N P=0.199N |
|LOGISTIC REGRESSION | P=0.429N P=0.495N P=0.488N | P=0.243N P=0.548N P=0.300N |
|COCHRAN-ARMITAGE | P=0.440N | P=0.252N |
|FISHER EXACT | P=0.492N P=0.492N | P=0.500N P=0.309N |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibrosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 3/49 (6%) 1/50 (2%) 1/50 (2%) | 1/50 (2%) 1/50 (2%) 1/50 (2%) |
|ADJUSTED (b) | 13.6% 5.9% 2.2% | 3.2% 2.9% 3.8% |
|TERMINAL (d) | 2/19 (11%) 1/17 (6%) 0/19 (0%) | 1/31 (3%) 0/28 (0%) 1/26 (4%) |
|FIRST INCIDENCE (DAYS) | 647 728 (T) 541 | 728 (T) 701 728 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.251N P=0.332N P=0.279N | P=0.637 P=0.746 P=0.723 |
|INCIDENTAL TUMOR | P=0.265N P=0.311N P=0.300N | P=0.666 P=0.738N P=0.723 |
|LOGISTIC REGRESSION | P=0.253N P=0.308N P=0.293N | P=0.653 P=0.758 P=0.723 |
|COCHRAN-ARMITAGE | P=0.266N | P=0.680 |
|FISHER EXACT | P=0.301N P=0.301N | P=0.753N P=0.753N |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05070 TEST: 01 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- VINYL TOLUENE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 100 PPM 300 PPM | CONTROL 100 PPM 300 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibroma or Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/49 (4%) 1/50 (2%) 2/50 (4%) | 3/50 (6%) 2/50 (4%) 1/50 (2%) |
|ADJUSTED (b) | 7.8% 4.3% 8.2% | 7.2% 5.9% 3.1% |
|TERMINAL (d) | 1/19 (5%) 0/17 (0%) 1/19 (5%) | 0/31 (0%) 1/28 (4%) 0/26 (0%) |
|FIRST INCIDENCE (DAYS) | 599 694 660 | 434 637 690 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.623 P=0.516N P=0.672N | P=0.286N P=0.518N P=0.338N |
|INCIDENTAL TUMOR | P=0.635N P=0.483N P=0.670N | P=0.199N P=0.455N P=0.199N |
|LOGISTIC REGRESSION | P=0.622 P=0.495N P=0.673N | P=0.243N P=0.548N P=0.300N |
|COCHRAN-ARMITAGE | P=0.602 | P=0.252N |
|FISHER EXACT | P=0.492N P=0.684N | P=0.500N P=0.309N |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, Sarcoma, |
| Neurofibroma, or Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 6/49 (12%) 3/50 (6%) 3/50 (6%) | 4/50 (8%) 3/50 (6%) 2/50 (4%) |
|ADJUSTED (b) | 23.5% 12.0% 10.2% | 10.2% 8.7% 6.9% |
|TERMINAL (d) | 3/19 (16%) 1/17 (6%) 1/19 (5%) | 1/31 (3%) 1/28 (4%) 1/26 (4%) |
|FIRST INCIDENCE (DAYS) | 599 519 541 | 434 637 690 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.203N P=0.270N P=0.210N | P=0.346N P=0.526N P=0.393N |
|INCIDENTAL TUMOR | P=0.227N P=0.241N P=0.238N | P=0.251N P=0.445N P=0.271N |
|LOGISTIC REGRESSION | P=0.218N P=0.233N P=0.221N | P=0.281N P=0.525N P=0.326N |
|COCHRAN-ARMITAGE | P=0.226N | P=0.291N |
|FISHER EXACT | P=0.233N P=0.233N | P=0.500N P=0.339N |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05070 TEST: 01 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- VINYL TOLUENE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 100 PPM 300 PPM | CONTROL 100 PPM 300 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, or Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 4/49 (8%) 2/50 (4%) 1/50 (2%) | 1/50 (2%) 1/50 (2%) 1/50 (2%) |
|ADJUSTED (b) | 16.5% 8.0% 2.2% | 3.2% 2.9% 3.8% |
|TERMINAL (d) | 2/19 (11%) 1/17 (6%) 0/19 (0%) | 1/31 (3%) 0/28 (0%) 1/26 (4%) |
|FIRST INCIDENCE (DAYS) | 643 519 541 | 728 (T) 701 728 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.132N P=0.359N P=0.155N | P=0.637 P=0.746 P=0.723 |
|INCIDENTAL TUMOR | P=0.169N P=0.345N P=0.190N | P=0.666 P=0.738N P=0.723 |
|LOGISTIC REGRESSION | P=0.148N P=0.329N P=0.172N | P=0.653 P=0.758 P=0.723 |
|COCHRAN-ARMITAGE | P=0.146N | P=0.680 |
|FISHER EXACT | P=0.329N P=0.175N | P=0.753N P=0.753N |
|=================================================================================================================================|
| |
|Testes |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 35/49 (71%) 31/42 (74%) 41/50 (82%) | |
|ADJUSTED (b) | 94.1% 93.2% 97.5% | |
|TERMINAL (d) | 17/19 (89%) 14/16 (88%) 18/19 (95%) | |
|FIRST INCIDENCE (DAYS) | 422 484 506 | |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.275 P=0.471N P=0.332 | |
|INCIDENTAL TUMOR | P=0.154 P=0.519 P=0.153 | |
|LOGISTIC REGRESSION | P=0.206 P=0.516 P=0.220 | |
|COCHRAN-ARMITAGE | P=0.131 | |
|FISHER EXACT | P=0.494 P=0.157 | |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05070 TEST: 01 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- VINYL TOLUENE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 100 PPM 300 PPM | CONTROL 100 PPM 300 PPM |
| | | |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 7/49 (14%) 2/20 (10%) 7/50 (14%) | 7/50 (14%) 0/10 (0%) 2/50 (4%) |
|ADJUSTED (b) | 28.0% 33.3% 26.8% | 19.6% 0.0% 7.7% |
|TERMINAL (d) | 2/19 (11%) 2/6 (33%) 3/19 (16%) | 4/31 (13%) 0/0 2/26 (8%) |
|FIRST INCIDENCE (DAYS) | 647 728 (T) 617 | 659 --- 728 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.539 P=0.262N P=0.566N | P=0.109N P=0.131N P=0.126N |
|INCIDENTAL TUMOR | P=0.376N P=0.611 P=0.411N | P=0.074N P=0.638N P=0.090N |
|LOGISTIC REGRESSION | P=0.506N P=0.656N P=0.548N | P=0.084N P=0.506N P=0.099N |
|COCHRAN-ARMITAGE | P=0.566 | P=0.070N |
|FISHER EXACT | P=0.483N P=0.597N | P=0.259N P=0.080N |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/49 (2%) 1/20 (5%) 1/50 (2%) | 0/50 (0%) 0/10 (0%) 2/50 (4%) |
|ADJUSTED (b) | 2.9% 16.7% 3.4% | 0.0% 0.0% 7.7% |
|TERMINAL (d) | 0/19 (0%) 1/6 (17%) 0/19 (0%) | 0/31 (0%) 0/0 2/26 (8%) |
|FIRST INCIDENCE (DAYS) | 623 728 (T) 669 | --- --- 728 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.637N P=0.642 P=0.739N | P=0.140 (e) P=0.200 |
|INCIDENTAL TUMOR | P=0.578N P=0.469 P=0.734N | P=0.140 (e) P=0.200 |
|LOGISTIC REGRESSION | P=0.598N P=0.500 P=0.763 | P=0.140 (e) P=0.200 |
|COCHRAN-ARMITAGE | P=0.619N | P=0.150 |
|FISHER EXACT | P=0.499 P=0.747N | (e) P=0.247 |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05070 TEST: 01 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- VINYL TOLUENE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 100 PPM 300 PPM | CONTROL 100 PPM 300 PPM |
| | | |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 8/49 (16%) 3/20 (15%) 8/50 (16%) | 7/50 (14%) 0/10 (0%) 4/50 (8%) |
|ADJUSTED (b) | 30.1% 50.0% 29.3% | 19.6% 0.0% 15.4% |
|TERMINAL (d) | 2/19 (11%) 3/6 (50%) 3/19 (16%) | 4/31 (13%) 0/0 4/26 (15%) |
|FIRST INCIDENCE (DAYS) | 623 728 (T) 617 | 659 --- 728 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.551 P=0.341N P=0.552N | P=0.345N P=0.131N P=0.358N |
|INCIDENTAL TUMOR | P=0.348N P=0.415 P=0.401N | P=0.269N P=0.638N P=0.299N |
|LOGISTIC REGRESSION | P=0.474N P=0.510 P=0.541N | P=0.286N P=0.506N P=0.312N |
|COCHRAN-ARMITAGE | P=0.562N | P=0.254N |
|FISHER EXACT | P=0.602N P=0.590N | P=0.259N P=0.262N |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/49 (0%) 2/20 (10%) 1/50 (2%) | 0/50 (0%) 0/10 (0%) 1/50 (2%) |
|ADJUSTED (b) | 0.0% 33.3% 5.3% | 0.0% 0.0% 3.8% |
|TERMINAL (d) | 0/19 (0%) 2/6 (33%) 1/19 (5%) | 0/31 (0%) 0/0 1/26 (4%) |
|FIRST INCIDENCE (DAYS) | --- 728 (T) 728 (T) | --- --- 728 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.549 P=0.042 * P=0.500 | P=0.336 (e) P=0.465 |
|INCIDENTAL TUMOR | P=0.549 P=0.042 * P=0.500 | P=0.336 (e) P=0.465 |
|LOGISTIC REGRESSION | P=0.549 P=0.042 * P=0.500 | P=0.336 (e) P=0.465 |
|COCHRAN-ARMITAGE | P=0.548 | P=0.352 |
|FISHER EXACT | P=0.081 P=0.505 | (e) P=0.500 |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05070 TEST: 01 PAGE 18
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- VINYL TOLUENE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 100 PPM 300 PPM | CONTROL 100 PPM 300 PPM |
| | | |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/49 (0%) 2/20 (10%) 1/50 (2%) | 0/50 (0%) 0/10 (0%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 33.3% 5.3% | 0.0% 0.0% 7.7% |
|TERMINAL (d) | 0/19 (0%) 2/6 (33%) 1/19 (5%) | 0/31 (0%) 0/0 2/26 (8%) |
|FIRST INCIDENCE (DAYS) | --- 728 (T) 728 (T) | --- --- 728 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.549 P=0.042 * P=0.500 | P=0.140 (e) P=0.200 |
|INCIDENTAL TUMOR | P=0.549 P=0.042 * P=0.500 | P=0.140 (e) P=0.200 |
|LOGISTIC REGRESSION | P=0.549 P=0.042 * P=0.500 | P=0.140 (e) P=0.200 |
|COCHRAN-ARMITAGE | P=0.548 | P=0.150 |
|FISHER EXACT | P=0.081 P=0.505 | (e) P=0.247 |
|=================================================================================================================================|
| |
|Urinary Bladder |
| Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/48 (0%) 0/12 (0%) 2/49 (4%) | 0/49 (0%) 0/9 (0%) 0/46 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 10.5% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/18 (0%) 0/2 (0%) 2/19 (11%) | 0/30 (0%) 0/0 0/25 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 728 (T) | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.167 (e) P=0.249 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.167 (e) P=0.249 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.167 (e) P=0.249 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.148 | (e) |
|FISHER EXACT | (e) P=0.253 | (e) (e) |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05070 TEST: 01 PAGE 19
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- VINYL TOLUENE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 100 PPM 300 PPM | CONTROL 100 PPM 300 PPM |
| | | |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 7/50 (14%) 6/50 (12%) 5/50 (10%) |
|ADJUSTED (b) | | 19.2% 19.6% 17.1% |
|TERMINAL (d) | | 4/31 (13%) 5/28 (18%) 2/26 (8%) |
|FIRST INCIDENCE (DAYS) | | 434 526 709 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.442N P=0.556N P=0.478N |
|INCIDENTAL TUMOR | | P=0.316N P=0.483N P=0.326N |
|LOGISTIC REGRESSION | | P=0.367N P=0.499N P=0.403N |
|COCHRAN-ARMITAGE | | P=0.344N |
|FISHER EXACT | | P=0.500N P=0.380N |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal or Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 8/50 (16%) 6/50 (12%) 5/50 (10%) |
|ADJUSTED (b) | | 22.2% 19.6% 17.1% |
|TERMINAL (d) | | 5/31 (16%) 5/28 (18%) 2/26 (8%) |
|FIRST INCIDENCE (DAYS) | | 434 526 709 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.350N P=0.448N P=0.376N |
|INCIDENTAL TUMOR | | P=0.236N P=0.376N P=0.238N |
|LOGISTIC REGRESSION | | P=0.279N P=0.385N P=0.302N |
|COCHRAN-ARMITAGE | | P=0.256N |
|FISHER EXACT | | P=0.387N P=0.277N |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05070 TEST: 01 PAGE 20
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- VINYL TOLUENE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 100 PPM 300 PPM | CONTROL 100 PPM 300 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Leukemia: Lymphocytic, Monocytic, Mononuclear, |
| or Undifferentiated |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 25/49 (51%) 26/50 (52%) 20/50 (40%) | 20/50 (40%) 16/50 (32%) 25/50 (50%) |
|ADJUSTED (b) | 67.8% 67.2% 52.9% | 47.0% 36.5% 66.5% |
|TERMINAL (d) | 8/19 (42%) 7/17 (41%) 5/19 (26%) | 9/31 (29%) 3/28 (11%) 14/26 (54%) |
|FIRST INCIDENCE (DAYS) | 422 393 512 | 582 421 444 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.145N P=0.462 P=0.190N | P=0.081 P=0.354N P=0.116 |
|INCIDENTAL TUMOR | P=0.144N P=0.580 P=0.169N | P=0.177 P=0.138N P=0.210 |
|LOGISTIC REGRESSION | P=0.159N P=0.542 P=0.196N | P=0.128 P=0.188N P=0.182 |
|COCHRAN-ARMITAGE | P=0.137N | P=0.124 |
|FISHER EXACT | P=0.541 P=0.184N | P=0.266N P=0.211 |
|=================================================================================================================================|
| |
|All Organs |
| Mesothelioma Benign, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 3/49 (6%) 1/50 (2%) 1/50 (2%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 7.8% 2.9% 2.7% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/19 (0%) 0/17 (0%) 0/19 (0%) | 0/31 (0%) 0/28 (0%) 0/26 (0%) |
|FIRST INCIDENCE (DAYS) | 492 623 638 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.238N P=0.301N P=0.262N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.316N P=0.283N P=0.352N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.334N P=0.304N P=0.402N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.266N | (e) |
|FISHER EXACT | P=0.301N P=0.301N | (e) (e) |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05070 TEST: 01 PAGE 21
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- VINYL TOLUENE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 100 PPM 300 PPM | CONTROL 100 PPM 300 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 48/49 (98%) 45/50 (90%) 49/50 (98%) | 44/50 (88%) 34/50 (68%) 39/50 (78%) |
|ADJUSTED (b) | 100.0% 100.0% 100.0% | 93.6% 80.3% 84.6% |
|TERMINAL (d) | 19/19 (100%) 17/17 (100%) 19/19 (100%) | 28/31 (90%) 20/28 (71%) 19/26 (73%) |
|FIRST INCIDENCE (DAYS) | 422 393 506 | 434 495 414 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.429N P=0.490N P=0.442N | P=0.418 P=0.158N P=0.521 |
|INCIDENTAL TUMOR | P=0.550 P=0.098N P=0.759 | P=0.245N P=0.010N* P=0.096N |
|LOGISTIC REGRESSION | P=0.633 P=0.080N P=0.648N | P=0.302N P=0.011N* P=0.161N |
|COCHRAN-ARMITAGE | P=0.451 | P=0.264N |
|FISHER EXACT | P=0.107N P=0.747 | P=0.014N* P=0.143N |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 38/49 (78%) 37/50 (74%) 29/50 (58%) | 28/50 (56%) 23/50 (46%) 31/50 (62%) |
|ADJUSTED (b) | 86.3% 88.8% 70.2% | 64.6% 51.8% 78.7% |
|TERMINAL (d) | 13/19 (68%) 13/17 (76%) 8/19 (42%) | 16/31 (52%) 8/28 (29%) 18/26 (69%) |
|FIRST INCIDENCE (DAYS) | 422 393 506 | 545 421 444 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.058N P=0.542 P=0.083N | P=0.124 P=0.347N P=0.160 |
|INCIDENTAL TUMOR | P=0.021N* P=0.415N P=0.026N* | P=0.271 P=0.128N P=0.305 |
|LOGISTIC REGRESSION | P=0.020N* P=0.429N P=0.017N* | P=0.220 P=0.215N P=0.290 |
|COCHRAN-ARMITAGE | P=0.018N* | P=0.228 |
|FISHER EXACT | P=0.430N P=0.031N* | P=0.212N P=0.342 |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05070 TEST: 01 PAGE 22
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- VINYL TOLUENE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 100 PPM 300 PPM | CONTROL 100 PPM 300 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 48/49 (98%) 50/50 (100%) 50/50 (100%) | 48/50 (96%) 41/50 (82%) 46/50 (92%) |
|ADJUSTED (b) | 100.0% 100.0% 100.0% | 100.0% 85.3% 93.9% |
|TERMINAL (d) | 19/19 (100%) 17/17 (100%) 19/19 (100%) | 31/31 (100%) 21/28 (75%) 23/26 (88%) |
|FIRST INCIDENCE (DAYS) | 422 393 506 | 434 421 414 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.423N P=0.363 P=0.491N | P=0.244 P=0.325N P=0.302 |
|INCIDENTAL TUMOR | P=0.457 P=0.500 P=0.581 | P=0.392N P=0.010N* P=0.242N |
|LOGISTIC REGRESSION | P=0.457 P=0.500 P=0.581 | P=0.524N P=0.020N* P=0.333N |
|COCHRAN-ARMITAGE | P=0.391 | P=0.500N |
|FISHER EXACT | P=0.495 P=0.495 | P=0.026N* P=0.339N |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).
--multipart-boundary
Content-type: text/plain
Range: bytes 151581-151581/151581
--multipart-boundary--