Skip to Main Navigation
Skip to Page Content

COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/2069

TDMS Study 05070-01 Pathology Tables

NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19




       Facility:  Midwest Research Institute

       Chemical CAS #:  25013154

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 5| 7| 5| 7| 7| 1| 7| 7| 7| 6| 6| 7| 7|             
                             DAY ON TEST   | 3| 7| 2| 2| 1| 2| 2| 0| 2| 2| 9| 2| 4| 3| 8| 2| 2| 6| 2| 2| 2| 8| 3| 2| 1|             
                                           | 0| 9| 9| 9| 3| 9| 8| 1| 9| 9| 2| 9| 5| 0| 2| 9| 9| 6| 8| 8| 8| 8| 0| 9| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Parasite Metazoan                    |                                        X                                X|             
      Artery, Inflammation, Chronic, Focal |                      2                                                   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                X  X                                         X  X        X|             
      Muscularis, Atrophy, Focal           |                      4                                                   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M|             
      Parasite Metazoan                    | X                                X                                       |             
      Mucosa, Inflammation, Chronic Active,|                                                                          |             
           Multifocal                      |                                              2                           |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +|             
      Inflammation, Chronic, Diffuse       |                            3                                             |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                                                                          |             
      Basophilic Focus                     |                   X                             X                    X   |             
      Basophilic Focus, Multiple           |          X                 X     X  X  X     X           X     X        X|             
      Clear Cell Focus                     |                                              X                           |             
      Cytomegaly, Multifocal               |                      3                                                   |             
      Cytoplasmic Alteration, Focal        |                                                                          |             
      Eosinophilic Focus                   |                                                                          |             
      Fatty Change, Diffuse                |                      3  2                                                |             
      Fatty Change, Multifocal             |                                                                          |             
      Fibrosis, Multifocal                 |                      2                                                   |             
      Granuloma, Multifocal                | 2  4           3  2     1  1  2                 2        2  2  2         |             
      Hepatodiaphragmatic Nodule           | X                                                                        |             
      Hepatodiaphragmatic Nodule, Multiple |                                     X                                    |             
      Hyperplasia, Multifocal, Nodular     |       2                                                                  |             
      Mixed Cell Focus                     |                                                                      X   |             
      Necrosis, Focal                      |                               2                                          |             
      Necrosis, Multifocal                 |             1        2                    2           2     2            |             
      Bile Duct, Hyperplasia, Focal        |                                                 2                        |             
      Bile Duct, Hyperplasia, Multifocal   |          1           2           1                                       |             
      Centrilobular, Atrophy, Multifocal   |                                                                          |             
      Centrilobular, Degeneration, Diffuse |                                                                          |             
      Centrilobular, Fatty Change, Diffuse |             4                             2                              |             
      Centrilobular, Necrosis, Multifocal  |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +                                                     +            |             
      Fat, Necrosis, Focal                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 5| 7| 5| 7| 7| 1| 7| 7| 7| 6| 6| 7| 7|             
                             DAY ON TEST   | 3| 7| 2| 2| 1| 2| 2| 0| 2| 2| 9| 2| 4| 3| 8| 2| 2| 6| 2| 2| 2| 8| 3| 2| 1|             
                                           | 0| 9| 9| 9| 3| 9| 8| 1| 9| 9| 2| 9| 5| 0| 2| 9| 9| 6| 8| 8| 8| 8| 0| 9| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy, Diffuse             |    3                                                                     |             
      Acinus, Atrophy, Focal               |                                  1                                       |             
      Acinus, Atrophy, Multifocal          |       2     2        2     1                 2  1        1               |             
      Acinus, Hyperplasia, Focal           |          3                                                               |             
      Artery, Inflammation, Chronic, Focal |                                           2                              |             
      Artery, Inflammation, Chronic Active,|                                                                          |             
           Multifocal                      |                      2                                                   |             
      Interlobular, Inflammation, Chronic, |                                                                          |             
           Diffuse                         |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic, Diffuse       |                                                    4                     |             
      Inflammation, Chronic Active, Focal  |                2                                                         |             
      Duct, Inflammation, Chronic Active,  |                                                                          |             
           Focal                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                      3                                                   |             
      Ulcer, Single, Subacute              |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                      3                                                   |             
      Mucosa, Cyst, Multiple               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess, Single                      |                                                                          |             
      Cardiomyopathy                       | 3     2  2     2  3     1  2     2  1  2     3  2     2  3  2  3     1  2|             
      Artery, Inflammation, Chronic Active,|                                                                          |             
           Multifocal                      |                                                                          |             
      Atrium Left, Thrombosis              |                                                                          |             
      Valve, Degeneration, Mucoid,         |                                                                          |             
          Multifocal                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Accessory Adrenal Cortical  |                                                                          |             
          Nodule                           |                   X                    X                                 |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                                        3                                 |             
      Angiectasis, Multifocal              |                               2                                         3|             
      Congestion                           |       4              3                                      2            |             
      Degeneration, Diffuse, Fatty         |             2                                                            |             
      Degeneration, Fatty, Focal           |          2        2        3                    3                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 5| 7| 5| 7| 7| 1| 7| 7| 7| 6| 6| 7| 7|             
                             DAY ON TEST   | 3| 7| 2| 2| 1| 2| 2| 0| 2| 2| 9| 2| 4| 3| 8| 2| 2| 6| 2| 2| 2| 8| 3| 2| 1|             
                                           | 0| 9| 9| 9| 3| 9| 8| 1| 9| 9| 2| 9| 5| 0| 2| 9| 9| 6| 8| 8| 8| 8| 0| 9| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Degeneration, Fatty, Multifocal      |                      3                                                   |             
      Hyperplasia, Focal                   |          2     2        3                    3                 1  2      |             
      Hypertrophy, Focal                   |             1                                                            |             
      Hypertrophy, Multifocal              |                                                                          |             
      Pigmentation, Diffuse, Hemosiderin   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Angiectasis, Multifocal              |                               2                                          |             
      Hyperplasia, Focal                   | 1                    3                          3     2                  |             
      Hyperplasia, Multifocal              |                                                                          |             
      Vacuolization Cytoplasmic, Diffuse   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Tissue, Focal                |                X                                                         |             
      Hyperplasia, Multifocal              |                                                 3                        |             
      Hypertrophy, Focal                   |                                           2                              |             
      Hypoplasia, Diffuse                  |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis, Focal    |                   4                       3                              |             
      Pars Distalis, Angiectasis,          |                                                                          |             
          Multifocal                       |                                                                          |             
      Pars Distalis, Cyst                  |                                                                2         |             
      Pars Distalis, Hemorrhage, Chronic,  |                                                                          |             
           Focal                           |                                           3                              |             
      Pars Distalis, Hyperplasia, Focal    |          3                                3                              |             
      Pars Distalis, Hyperplasia           |                                                       3                  |             
      Pars Distalis, Pigmentation, Diffuse,|                                                                          |             
           Hemosiderin                     |                                                                          |             
      Pars Intermedia, Pigmentation,       |                                                                          |             
          Diffuse, Hemosiderin             |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      C-Cell, Hyperplasia, Focal           | 1                                                                        |             
      C-Cell, Hyperplasia, Multifocal      |          2        2     1              1  1  2              2  2        3|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M|             
      Hyperplasia                          | 3                                                                        |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Granulomatous          |                      2                                                   |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 5| 7| 5| 7| 7| 1| 7| 7| 7| 6| 6| 7| 7|             
                             DAY ON TEST   | 3| 7| 2| 2| 1| 2| 2| 0| 2| 2| 9| 2| 4| 3| 8| 2| 2| 6| 2| 2| 2| 8| 3| 2| 1|             
                                           | 0| 9| 9| 9| 3| 9| 8| 1| 9| 9| 2| 9| 5| 0| 2| 9| 9| 6| 8| 8| 8| 8| 0| 9| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Angiectasis, Multifocal              |                                              2                           |             
      Congestion, Diffuse                  |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                           4                              |             
      Dilatation                           |                      4                                                   |             
      Inflammation, Acute, Multifocal      |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Endometrium, Hyperplasia, Focal      |                         1                                                |             
      Epithelium, Hyperplasia, Diffuse     |                                                                          |             
      Epithelium, Hyperplasia, Focal       |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                  +                                       |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                         2|             
      Metaplasia, Diffuse, Osseous         |    3                                                                     |             
      Myeloid Cell, Hyperplasia            |                                                                3     2   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Re Cell                 |    2                                                                     |             
      Mediastinal, Hemorrhage              |             2                    3                                       |             
      Pancreatic, Hemorrhage               |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Plasma Cell             |                                           2        3                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +|             
      Hemorrhage                           |                               1                                          |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Hyperplasia, Re Cell                 |                                                                         2|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma, Multifocal                |                   2                                                      |             
      Hematopoietic Cell Proliferation     |                         2                                            2  1|             
      Hyperplasia, Multifocal, Reticulum   |                                                                          |             
          Cell                             |                                                                          |             
      Pigmentation, Hemosiderin            |                         2  3  2  2  3  2                                 |             
      Capsule, Ectopic Tissue              |                                                                          |             
      Capsule, Infiltration Cellular,      |                                                                          |             
          Multifocal, Lymphocyte           |                3                                                         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  M  +  +  M  M  +  M  M  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Parathyroid Gland            |                      X                                                   |             
      Hyperplasia, Diffuse, Tubular        |                3        2        2           2              2            |             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                                                                          |             
      Artery, Mediastinum, Inflammation,   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 5| 7| 5| 7| 7| 1| 7| 7| 7| 6| 6| 7| 7|             
                             DAY ON TEST   | 3| 7| 2| 2| 1| 2| 2| 0| 2| 2| 9| 2| 4| 3| 8| 2| 2| 6| 2| 2| 2| 8| 3| 2| 1|             
                                           | 0| 9| 9| 9| 3| 9| 8| 1| 9| 9| 2| 9| 5| 0| 2| 9| 9| 6| 8| 8| 8| 8| 0| 9| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
           Chronic Active, Multifocal      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Ectasia, Focal                       |                                                                          |             
      Ectasia, Multifocal                  |       2        2     2        3                       2              2  2|             
      Hyperplasia, Diffuse                 | 2  2        1     2                    1  2  1              2            |             
      Hyperplasia, Focal                   |                                                                          |             
      Hyperplasia, Multifocal              |                                                                2         |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |                                                                         2|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Hyperostosis                         |                                                                          |             
      Osteopetrosis                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |    X           X        X     X        X              X     X            |             
      Hemorrhage, Focal                    |                      1                                                   |             
      Hemorrhage, Multifocal               |                                                                          |             
      Hydrocephalus                        |                         2     2                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute, Focal           |                               2                                          |             
      Inflammation, Chronic, Diffuse       |                            4                                             |             
      Inflammation, Chronic, Focal         |          4                                         2     3              2|             
      Inflammation, Chronic Active, Focal  |                                        3                    1     2  3   |             
      Submucosa, Dilatation, Multifocal    |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                     3                                    |             
      Hemorrhage, Acute, Multifocal        |                                  2                                       |             
      Interstitium, Inflammation, Chronic, |                                                                          |             
           Focal                           |                                  2                                       |             
      Interstitium, Inflammation, Chronic, |                                                                          |             
           Multifocal                      |                3                                                         |             
      Peribronchial, Hyperplasia, Lymphoid,|                                                                          |             
           Multifocal                      |                                                    2                     |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Exudate                       |                                                                          |             
      Lumen, Foreign Body                  | 4                                                                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 5| 7| 5| 7| 7| 1| 7| 7| 7| 6| 6| 7| 7|             
                             DAY ON TEST   | 3| 7| 2| 2| 1| 2| 2| 0| 2| 2| 9| 2| 4| 3| 8| 2| 2| 6| 2| 2| 2| 8| 3| 2| 1|             
                                           | 0| 9| 9| 9| 3| 9| 8| 1| 9| 9| 2| 9| 5| 0| 2| 9| 9| 6| 8| 8| 8| 8| 0| 9| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Mucosa, Inflammation, Chronic        | 4                                                                        |             
      Mucosa, Inflammation, Chronic Active |                                                                          |             
      Mucosa, Metaplasia, Focal            | 3                                                                        |             
      Mucosa, Thrombosis, Multifocal       |             3                                                            |             
      Nasolacrimal Duct, Exudate           |    2                 2                                                   |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |             2     2           2              1                           |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic Active                  |    3                 2                                                   |             
      Olfactory Epithelium, Hyperplasia,   |                                                                          |             
           Eosinophil                      |                                                 2                        |             
      Respiratory Epithelium, Hyperplasia  |                                                       2              1   |             
      Respiratory Epithelium, Hyperplasia, |                                                                          |             
           Multifocal                      | 4                                                                        |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute, Focal           |                               2                                          |             
      Inflammation, Chronic, Focal         |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +                                                                     |             
      Cataract                             |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                +         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 4  3  3  2  2  3  2  3  4  3  4  3  3  2  2  1  4     3  3  3     1  3  1|             
      Pigmentation, Diffuse                |       1              3                                                  1|             
      Pigmentation, Multifocal             |          2     2  1     2     2        2     1                           |             
      Cortex, Cyst                         |                                                 X                        |             
      Cortex, Hyperplasia, Atypical, Focal |                                                                          |             
      Cortex, Inflammation, Focal,         |                                                                          |             
          Suppurative                      |                                                                          |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Necrosis, Multifocal            |                                                                          |             
      Transitional Epithelium,             |                                                                          |             
          Mineralization, Focal            |                                                                          |             
      Transitional Epithelium,             |                                                                          |             
          Mineralization, Multifocal       |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 7| 5| 7| 6| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 5| 3| 3| 3| 7| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 2| 5|            |
                                           | 1| 1| 4| 1| 1| 3| 1| 0| 0| 0| 3| 8| 1| 1| 1| 1| 1| 1| 0| 0| 5| 8| 0| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic Active         |          2                                                               |      1  2.0|
      Parasite Metazoan                    |                                                                          |      2     |
      Artery, Inflammation, Chronic, Focal |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |       X     X                                                            |      7     |
      Muscularis, Atrophy, Focal           |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Parasite Metazoan                    |                                                                          |      2     |
      Mucosa, Inflammation, Chronic Active,|                                                                          |            |
           Multifocal                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Chronic, Diffuse       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis, Focal                   |                               1     3           3                        |      3  2.3|
      Basophilic Focus                     |                         X     X              X  X                    X   |      8     |
      Basophilic Focus, Multiple           | X        X  X  X  X                 X     X        X  X           X      |     19     |
      Clear Cell Focus                     |                                                                          |      1     |
      Cytomegaly, Multifocal               |                                                                          |      1  3.0|
      Cytoplasmic Alteration, Focal        |                                                 3                        |      1  3.0|
      Eosinophilic Focus                   |                                                                      X   |      1     |
      Fatty Change, Diffuse                |                                  2                                       |      3  2.3|
      Fatty Change, Multifocal             |                   1           1        1  1        1        3           4|      7  1.7|
      Fibrosis, Multifocal                 |                                                                          |      1  2.0|
      Granuloma, Multifocal                |          1              1  1  1     2        2     2              1      |     19  1.8|
      Hepatodiaphragmatic Nodule           |                                                                          |      1     |
      Hepatodiaphragmatic Nodule, Multiple |                                                                          |      1     |
      Hyperplasia, Multifocal, Nodular     |                                                                          |      1  2.0|
      Mixed Cell Focus                     |                                                                          |      1     |
      Necrosis, Focal                      |                                                                          |      1  2.0|
      Necrosis, Multifocal                 |                   2                                            2        1|      8  1.8|
      Bile Duct, Hyperplasia, Focal        |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia, Multifocal   |                      2                                   1              3|      6  1.7|
      Centrilobular, Atrophy, Multifocal   |                      3                                                   |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   8                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 7| 5| 7| 6| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 5| 3| 3| 3| 7| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 2| 5|            |
                                           | 1| 1| 4| 1| 1| 3| 1| 0| 0| 0| 3| 8| 1| 1| 1| 1| 1| 1| 0| 0| 5| 8| 0| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Centrilobular, Degeneration, Diffuse |                                  2                                       |      1  2.0|
      Centrilobular, Fatty Change, Diffuse |                      4                                         4         |      4  3.2|
      Centrilobular, Necrosis, Multifocal  |                                                             2            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                    +           +         |   4        |
      Fat, Necrosis, Focal                 |                                                    3                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy, Diffuse             |                            4                                             |      2  3.5|
      Acinus, Atrophy, Focal               |                                                                          |      1  1.0|
      Acinus, Atrophy, Multifocal          | 2  2                                      1     1     1                 2|     13  1.5|
      Acinus, Hyperplasia, Focal           |                                                                          |      1  3.0|
      Artery, Inflammation, Chronic, Focal |                                     3                                    |      2  2.5|
      Artery, Inflammation, Chronic Active,|                                                                          |            |
           Multifocal                      |                                                                          |      1  2.0|
      Interlobular, Inflammation, Chronic, |                                                                          |            |
           Diffuse                         |                            4                                             |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic, Diffuse       |                                                                          |      1  4.0|
      Inflammation, Chronic Active, Focal  |                                                                          |      1  2.0|
      Duct, Inflammation, Chronic Active,  |                                                                          |            |
           Focal                           |                                                    1                     |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic Active         |                                  4                             3         |      3  3.3|
      Ulcer, Single, Subacute              |                                                                         3|      1  3.0|
      Epithelium, Hyperplasia              |                                  4                                      2|      2  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Mucosa, Cyst, Multiple               |                         2              2                                 |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Abscess, Single                      |                                                                         2|      1  2.0|
      Cardiomyopathy                       | 2  2  1  3  3        3  3  2     2     2  1  2  2  2  2  2  1     2      |     36  2.1|
      Artery, Inflammation, Chronic Active,|                                                                          |            |
           Multifocal                      |                                     4                                    |      1  4.0|
      Atrium Left, Thrombosis              |                                                                4        2|      2  3.0|
      Valve, Degeneration, Mucoid,         |                                                                          |            |
          Multifocal                       |                         3                                                |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   9                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 7| 5| 7| 6| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 5| 3| 3| 3| 7| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 2| 5|            |
                                           | 1| 1| 4| 1| 1| 3| 1| 0| 0| 0| 3| 8| 1| 1| 1| 1| 1| 1| 0| 0| 5| 8| 0| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Capsule, Accessory Adrenal Cortical  |                                                                          |            |
          Nodule                           |                         X  X                    X                        |      5     |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis, Focal                   |                                                          2               |      2  2.5|
      Angiectasis, Multifocal              |          1        2                                                      |      4  2.0|
      Congestion                           |                                        3                                 |      4  3.0|
      Degeneration, Diffuse, Fatty         |                                                                          |      1  2.0|
      Degeneration, Fatty, Focal           |                2        2        2                                      3|      8  2.4|
      Degeneration, Fatty, Multifocal      | 2                                                                        |      2  2.5|
      Hyperplasia, Focal                   |                2     1  3                                                |      9  2.1|
      Hypertrophy, Focal                   |             2  4                    1                                    |      4  2.0|
      Hypertrophy, Multifocal              |                                                       2              2   |      2  2.0|
      Pigmentation, Diffuse, Hemosiderin   |                                  3                                      2|      2  2.5|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Angiectasis, Multifocal              |                                                                          |      1  2.0|
      Hyperplasia, Focal                   |                                                                2         |      5  2.2|
      Hyperplasia, Multifocal              |                                           2                             2|      2  2.0|
      Vacuolization Cytoplasmic, Diffuse   |                                  2                                       |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectopic Tissue, Focal                |                                                                          |      1     |
      Hyperplasia, Multifocal              |    2                                                                     |      2  2.5|
      Hypertrophy, Focal                   |                                                                   1      |      2  1.5|
      Hypoplasia, Diffuse                  | 3                                                                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Angiectasis, Focal    |             2           3                                                |      4  3.0|
      Pars Distalis, Angiectasis,          |                                                                          |            |
          Multifocal                       |                   1                                                     4|      2  2.5|
      Pars Distalis, Cyst                  |       3                                               2     2     3      |      5  2.4|
      Pars Distalis, Hemorrhage, Chronic,  |                                                                          |            |
           Focal                           |                                                                          |      1  3.0|
      Pars Distalis, Hyperplasia, Focal    |             3                                                            |      3  3.0|
      Pars Distalis, Hyperplasia           |                                                                          |      1  3.0|
      Pars Distalis, Pigmentation, Diffuse,|                                                                          |            |
           Hemosiderin                     |                                  2                                       |      1  2.0|
      Pars Intermedia, Pigmentation,       |                                                                          |            |
          Diffuse, Hemosiderin             |                                  2                                       |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 7| 5| 7| 6| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 5| 3| 3| 3| 7| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 2| 5|            |
                                           | 1| 1| 4| 1| 1| 3| 1| 0| 0| 0| 3| 8| 1| 1| 1| 1| 1| 1| 0| 0| 5| 8| 0| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                 X     1                  |      2  1.0|
      C-Cell, Hyperplasia, Focal           |          3                                                               |      2  2.0|
      C-Cell, Hyperplasia, Multifocal      | 2                 2  3  2     2     2     2     2  2     2        2  3   |     21  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          | 3                                   4                                    |      3  3.3|
      Inflammation, Acute                  |                                                       2           2      |      2  2.0|
      Inflammation, Chronic Active         |                                     4                                    |      1  4.0|
      Inflammation, Granulomatous          |          4                                                               |      2  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis, Multifocal              |                                                                          |      1  2.0|
      Congestion, Diffuse                  |                         2                                                |      1  2.0|
      Hyperplasia                          |       3                                                                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1  4.0|
      Dilatation                           |                                                                          |      1  4.0|
      Inflammation, Acute, Multifocal      |                            4                                             |      1  4.0|
      Inflammation, Chronic Active         |       4                                                                  |      1  4.0|
      Endometrium, Hyperplasia, Focal      |                                                                          |      1  1.0|
      Epithelium, Hyperplasia, Diffuse     |                                                                      2   |      1  2.0|
      Epithelium, Hyperplasia, Focal       |                                     2                 3                  |      2  2.5|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                      +                                                   |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                2                                                         |      2  2.0|
      Metaplasia, Diffuse, Osseous         |                                                                          |      1  3.0|
      Myeloid Cell, Hyperplasia            |       4                    4                             2     2         |      6  2.8|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Re Cell                 |                                                                          |      1  2.0|
      Mediastinal, Hemorrhage              |          3                                                              4|      4  3.0|
      Pancreatic, Hemorrhage               |                                                                         4|      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  11                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 7| 5| 7| 6| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 5| 3| 3| 3| 7| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 2| 5|            |
                                           | 1| 1| 4| 1| 1| 3| 1| 0| 0| 0| 3| 8| 1| 1| 1| 1| 1| 1| 0| 0| 5| 8| 0| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Plasma Cell             |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hemorrhage                           |          2                                                              4|      3  2.3|
      Hyperplasia, Plasma Cell             |                            2                                             |      1  2.0|
      Hyperplasia, Re Cell                 |          2     2                                                     2   |      4  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Granuloma, Multifocal                |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |       4                    3                                             |      5  2.4|
      Hyperplasia, Multifocal, Reticulum   |                                                                          |            |
          Cell                             |                                           2                              |      1  2.0|
      Pigmentation, Hemosiderin            |             1                       2           2  3  2                  |     11  2.2|
      Capsule, Ectopic Tissue              |                                        X                                 |      1     |
      Capsule, Infiltration Cellular,      |                                                                          |            |
          Multifocal, Lymphocyte           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  M  M  +  M  +  M  M  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +|  38        |
      Ectopic Parathyroid Gland            |                                                                          |      1     |
      Hyperplasia, Diffuse, Tubular        |                                                       2                  |      6  2.2|
      Infiltration Cellular,               |                                                                          |            |
          Polymorphonuclear                |    4                                                                     |      1  4.0|
      Artery, Mediastinum, Inflammation,   |                                                                          |            |
           Chronic Active, Multifocal      |                                     4                                    |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Ectasia, Focal                       |    2                       2                                             |      2  2.0|
      Ectasia, Multifocal                  |          2              2     2     2                    1               |     12  2.0|
      Hyperplasia, Diffuse                 | 2           1        2                       2  2              3         |     14  1.8|
      Hyperplasia, Focal                   |                                           2                              |      1  2.0|
      Hyperplasia, Multifocal              |                                     2                 1  1               |      4  1.5|
      Inflammation, Granulomatous,         |                                                                          |            |
          Multifocal                       |                                  2                                       |      2  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperostosis                         |                      3                                                   |      1  3.0|
      Osteopetrosis                        |                                                                3         |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 7| 5| 7| 6| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 5| 3| 3| 3| 7| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 2| 5|            |
                                           | 1| 1| 4| 1| 1| 3| 1| 0| 0| 0| 3| 8| 1| 1| 1| 1| 1| 1| 0| 0| 5| 8| 0| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                      X        X     X  X                                 |     11     |
      Hemorrhage, Focal                    |                               3                                          |      2  2.0|
      Hemorrhage, Multifocal               |                                                             4            |      1  4.0|
      Hydrocephalus                        |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Inflammation, Acute, Focal           |                                                                          |      1  2.0|
      Inflammation, Chronic, Diffuse       |                                                                          |      1  4.0|
      Inflammation, Chronic, Focal         |                                                                          |      4  2.8|
      Inflammation, Chronic Active, Focal  |          3     3                                      2  3  3  3         |     10  2.6|
      Submucosa, Dilatation, Multifocal    |                         3                                                |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Autolysis                            |                                                                          |      1  3.0|
      Hemorrhage, Acute, Multifocal        |                                                                          |      1  2.0|
      Interstitium, Inflammation, Chronic, |                                                                          |            |
           Focal                           |                                                    2                     |      2  2.0|
      Interstitium, Inflammation, Chronic, |                                                                          |            |
           Multifocal                      |                                                                          |      1  3.0|
      Peribronchial, Hyperplasia, Lymphoid,|                                                                          |            |
           Multifocal                      |       2                                                                  |      2  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lumen, Exudate                       |    1                                                                     |      1  1.0|
      Lumen, Foreign Body                  |    1                                                                     |      2  2.5|
      Mucosa, Inflammation, Chronic        |                                                          1               |      2  2.5|
      Mucosa, Inflammation, Chronic Active |    1                                                                     |      1  1.0|
      Mucosa, Metaplasia, Focal            |                                                                          |      1  3.0|
      Mucosa, Thrombosis, Multifocal       |                                                                         3|      2  3.0|
      Nasolacrimal Duct, Exudate           |                                                             1  1        1|      5  1.4|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic                         | 1           1        1              3           1     2  1        1  1   |     13  1.5|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic Active                  |                                                             3  2        1|      5  2.2|
      Olfactory Epithelium, Hyperplasia,   |                                                                          |            |
           Eosinophil                      |                   1                                                      |      2  1.5|
      Respiratory Epithelium, Hyperplasia  | 2     1           1           1                             1            |      7  1.3|
      Respiratory Epithelium, Hyperplasia, |                                                                          |            |
           Multifocal                      |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 7| 5| 7| 6| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 5| 3| 3| 3| 7| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 2| 5|            |
                                           | 1| 1| 4| 1| 1| 3| 1| 0| 0| 0| 3| 8| 1| 1| 1| 1| 1| 1| 0| 0| 5| 8| 0| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Acute, Focal           |                                                                          |      1  2.0|
      Inflammation, Chronic, Focal         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                             +            |   2        |
      Cataract                             |                                                             3            |      1  3.0|
      Retina, Degeneration                 |                                                             4            |      1  4.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nephropathy, Chronic                 | 4  3  2  3  4     4  2  3  3  3  3  2  2  4  2  4  2  3  2     3  3  1  2|     46  2.7|
      Pigmentation, Diffuse                |                      3           4           3  3                       2|      8  2.5|
      Pigmentation, Multifocal             |                   1                                2     2     1         |     11  1.6|
      Cortex, Cyst                         |                                                                          |      1     |
      Cortex, Hyperplasia, Atypical, Focal |             3     2                                                      |      2  2.5|
      Cortex, Inflammation, Focal,         |                                                                          |            |
          Suppurative                      |                                                       1                  |      1  1.0|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Necrosis, Multifocal            |                      2                                                  2|      2  2.0|
      Transitional Epithelium,             |                                                                          |            |
          Mineralization, Focal            |                                     2                                    |      1  2.0|
      Transitional Epithelium,             |                                                                          |            |
          Mineralization, Multifocal       |          2                                      3  2                     |      3  2.3|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 4| 4| 7| 7| 7| 7| 7| 4| 6| 7| 7| 6| 4| 7| 6| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 4| 1| 3| 3| 3| 3| 3| 5| 0| 1| 3| 8| 9| 3| 9| 3| 3| 3| 8| 0| 3| 3|             
                                           | 0| 1| 1| 4| 4| 1| 1| 1| 0| 0| 6| 6| 4| 1| 1| 9| 1| 7| 1| 1| 0| 3| 9| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    300 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Parasite Metazoan                    |                      X     X        X                                X   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                      X                                X  X     X         |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  M  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                           X                       X      |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Muscularis, Fibrosis, Focal          |                                                                      2   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                      X   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                                                                3  2      |             
      Angiectasis, Multifocal              |                3                                                         |             
      Basophilic Focus                     |             X                          X           X     X     X        X|             
      Basophilic Focus, Multiple           | X  X              X  X     X                          X     X     X      |             
      Cytomegaly, Multifocal               |                                                                          |             
      Cytoplasmic Alteration, Focal        |                2                                                         |             
      Fatty Change, Focal                  |                            2                                         2   |             
      Fatty Change, Multifocal             |                1                                                         |             
      Granuloma, Multifocal                |             1                          2  3              2     2        1|             
      Hemorrhage, Acute, Multifocal        |                                                                          |             
      Hepatodiaphragmatic Nodule           |    X              X                                               X      |             
      Hyperplasia, Multifocal, Nodular     |                                                 1                        |             
      Inflammation, Chronic, Multifocal    |             2                                                            |             
      Mitotic Alteration                   |                                                                          |             
      Mixed Cell Focus                     |                                                          X              X|             
      Mixed Cell Focus, Two                |                                                       X                  |             
      Necrosis, Multifocal                 |                                     1           2     2                  |             
      Bile Duct, Hyperplasia, Multifocal   |                   1                             3                        |             
      Centrilobular, Fatty Change, Diffuse |       4                       4     3                                    |             
      Centrilobular, Fatty Change,         |                                                                          |             
          Multifocal                       |                                                                          |             
      Centrilobular, Necrosis, Diffuse     |       2                                                                  |             
      Centrilobular, Necrosis, Multifocal  |                               1                                          |             
      Portal, Inflammation, Chronic,       |                                                                          |             
          Multifocal                       |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Artery, Inflammation, Multifocal,    |                                                                          |             
           Necrotizing                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 4| 4| 7| 7| 7| 7| 7| 4| 6| 7| 7| 6| 4| 7| 6| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 4| 1| 3| 3| 3| 3| 3| 5| 0| 1| 3| 8| 9| 3| 9| 3| 3| 3| 8| 0| 3| 3|             
                                           | 0| 1| 1| 4| 4| 1| 1| 1| 0| 0| 6| 6| 4| 1| 1| 9| 1| 7| 1| 1| 0| 3| 9| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    300 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Fat, Inflammation, Focal, Necrotizing|                                                                          |             
      Fat, Necrosis, Focal                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Focal, Granulomatous   |                                                                          |             
      Acinus, Atrophy, Focal               |                                                                      2   |             
      Acinus, Atrophy, Multifocal          | 2     2                    3     2                       2               |             
      Duct, Cyst, Multiple                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
      Mucosa, Palate, Inflammation,        |                                                                          |             
          Chronic, Diffuse                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Parotid Gland, Inflammation, Chronic |                                                                          |             
          Active, Focal                    |                                                                1         |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                       +                  |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Chronic, Diffuse                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 3  2     3  2  1  3  2  2  2  1  1  3     2  2  1  2     2  1  1  2  2  2|             
      Artery, Inflammation, Chronic Active,|                                                                          |             
           Focal                           |                                                                          |             
      Atrium Left, Thrombosis              |                                                                          |             
      Epicardium, Inflammation, Chronic    |                                                                          |             
          Active, Focal                    |                                                                          |             
      Myocardium, Degeneration, Focal      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Capsule, Fibrosis,        |                                                                          |             
          Multifocal                       |                                                                          |             
      Capsule, Accessory Adrenal Cortical  |                                                                          |             
          Nodule                           |    X                          X        X                       X         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Multifocal              |                3                                                        2|             
      Atrophy                              |                                                                          |             
      Congestion                           |    2                                                                     |             
      Degeneration, Diffuse, Fatty         |                               3                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 4| 4| 7| 7| 7| 7| 7| 4| 6| 7| 7| 6| 4| 7| 6| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 4| 1| 3| 3| 3| 3| 3| 5| 0| 1| 3| 8| 9| 3| 9| 3| 3| 3| 8| 0| 3| 3|             
                                           | 0| 1| 1| 4| 4| 1| 1| 1| 0| 0| 6| 6| 4| 1| 1| 9| 1| 7| 1| 1| 0| 3| 9| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    300 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Degeneration, Fatty, Focal           |                   2                 2                 4           2  3   |             
      Degeneration, Fatty, Multifocal      |       3                                                                  |             
      Hyperplasia, Focal                   |                                                                          |             
      Hyperplasia, Multifocal              |                                                                          |             
      Hypertrophy, Focal                   |                                                                          |             
      Hypertrophy, Multifocal              | 3                                                                        |             
      Pigmentation, Diffuse, Hemosiderin   |                                                                          |             
      Pigmentation, Hemosiderin, Multifocal|                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  M  +  +  M  +  +  +  +|             
      Angiectasis, Multifocal              |                3                                                         |             
      Hyperplasia, Focal                   | 1           2                 2                          2               |             
      Hyperplasia, Multifocal              |                                                                      2   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |    1  3           2                                                      |             
      Hypertrophy, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  +  +  +  M  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis, Focal    |                                                                         2|             
      Pars Distalis, Concretion            |                                                                          |             
      Pars Distalis, Cyst                  |                   3                 4                                    |             
      Pars Distalis, Hyperplasia, Focal    |                                                                         3|             
      Pars Distalis, Hyperplasia           |                                                       3                  |             
      Pars Distalis, Hyperplasia,          |                                                                          |             
          Multifocal                       |                                                                          |             
      Pars Nervosa, Pigmentation, Diffuse  |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                   X      |             
      C-Cell, Hyperplasia, Focal           |                                                    2                 2   |             
      C-Cell, Hyperplasia, Multifocal      |                   1                 1                                    |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  M  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Ectasia                              |                                     2                                    |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |    2                                                                     |             
      Inflammation, Granulomatous          |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion, Diffuse                  |    2                                                                     |             
      Cyst                                 |                      X              X                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 4| 4| 7| 7| 7| 7| 7| 4| 6| 7| 7| 6| 4| 7| 6| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 4| 1| 3| 3| 3| 3| 3| 5| 0| 1| 3| 8| 9| 3| 9| 3| 3| 3| 8| 0| 3| 3|             
                                           | 0| 1| 1| 4| 4| 1| 1| 1| 0| 0| 6| 6| 4| 1| 1| 9| 1| 7| 1| 1| 0| 3| 9| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    300 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenomyosis, Focal                   |                                                    2                     |             
      Cyst                                 |                                                                          |             
      Dilatation                           |                                                                2         |             
      Inflammation, Chronic Active         |                                                                          |             
      Epithelium, Hyperplasia, Diffuse     |                                                    2                     |             
      Epithelium, Hyperplasia, Focal       |    4                                                                     |             
      Lumen, Hemorrhage                    |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                            +                                             |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                   4      |             
      Hyperplasia, Megakaryocyte           |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Myeloid Cell, Hyperplasia            |                                              3                           |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Hyperplasia, Re Cell    |                            2                                             |             
      Mediastinal, Pigmentation, Diffuse,  |                                                                          |             
           Hemosiderin                     |                                                                          |             
      Pancreatic, Pigmentation, Hemosiderin|                                                                          |             
      Renal, Hyperplasia, Plasma Cell      |                                                                      3   |             
      Renal, Hyperplasia, Re Cell          |                                                                      3   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                      2   |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             |                         3                             4                  |             
      Hyperplasia, Re Cell                 |                                                                          |             
      Artery, Inflammation, Chronic Active,|                                                                          |             
           Focal                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                        3                                 |             
      Hyperplasia, Re Cell                 |                                           2                              |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      | 2                                                                        |             
      Fibrosis, Multifocal                 |                                                 3                        |             
      Hematopoietic Cell Proliferation     |                                              2                    3      |             
      Pigmentation, Hemosiderin            |             1     2     2              2  2           2              2  2|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  M  +|             
      Hyperplasia, Diffuse, Tubular        | 3              2     3  2        3     2        2           3  2        2|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 4| 4| 7| 7| 7| 7| 7| 4| 6| 7| 7| 6| 4| 7| 6| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 4| 1| 3| 3| 3| 3| 3| 5| 0| 1| 3| 8| 9| 3| 9| 3| 3| 3| 8| 0| 3| 3|             
                                           | 0| 1| 1| 4| 4| 1| 1| 1| 0| 0| 6| 6| 4| 1| 1| 9| 1| 7| 1| 1| 0| 3| 9| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    300 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Ectasia, Diffuse                     |                                              3                           |             
      Ectasia, Focal                       |    4           4                                                         |             
      Ectasia, Multifocal                  |       3           1  3                    2        3           2  2  3   |             
      Hyperplasia, Diffuse                 | 4  1                 2           3        2     2     3        3  2      |             
      Hyperplasia, Focal                   |                         4                                                |             
      Artery, Inflammation, Chronic Active,|                                                                          |             
           Focal                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal, Squamous         |                                                 4                        |             
      Inflammation, Chronic Active, Focal  |                                                 3                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                                                                          |             
      Osteopetrosis                        |                   4                 3                    3               |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Inflammation, Diffuse, Proliferative |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          | X     X              X  X  X     X        4     X  X           X         |             
      Hydrocephalus                        |                         3                 2        3                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  M  M  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal, Papillary        |                                                                          |             
      Inflammation, Acute, Diffuse         |                                                                          |             
      Inflammation, Chronic, Focal         |                                        1                                 |             
      Inflammation, Chronic Active, Focal  | 2                 1  1              2                                    |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atelectasis, Focal                   |                                                                         1|             
      Inflammation, Chronic, Multifocal    |                            3                                             |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                    3                     |             
      Bronchiole, Alveolus, Inflammation,  |                                                                          |             
           Acute, Multifocal               |                                                       3                  |             
      Interstitium, Inflammation, Chronic, |                                                                          |             
           Multifocal                      |                                                                          |             
      Pleura, Inflammation, Multifocal,    |                                                                          |             
           Subacute                        |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Exudate                       |                                                                          |             
      Lumen, Foreign Body                  |                                                                          |             
      Mucosa, Inflammation, Acute          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 4| 4| 7| 7| 7| 7| 7| 4| 6| 7| 7| 6| 4| 7| 6| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 4| 1| 3| 3| 3| 3| 3| 5| 0| 1| 3| 8| 9| 3| 9| 3| 3| 3| 8| 0| 3| 3|             
                                           | 0| 1| 1| 4| 4| 1| 1| 1| 0| 0| 6| 6| 4| 1| 1| 9| 1| 7| 1| 1| 0| 3| 9| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    300 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Mucosa, Inflammation, Chronic        |                                                                          |             
      Mucosa, Inflammation, Chronic Active |                                                                1         |             
      Nasolacrimal Duct, Exudate           |       3     1                                                            |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         | 1  2           1        1                 1     2  1           1        1|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic Active                  |       3                                                                  |             
      Olfactory Epithelium, Atrophy        |                                                                          |             
      Olfactory Epithelium, Cyst           | 2     1        2  1        1     1                 1              1      |             
      Olfactory Epithelium, Erosion        |                      2                 2                 2               |             
      Olfactory Epithelium, Hyperplasia,   |                                                                          |             
           Eosinophil                      |       2     1              1        2     1        2                    1|             
      Respiratory Epithelium, Cyst         | 1                          1           1                                 |             
      Respiratory Epithelium, Hyperplasia, |                                                                          |             
           Eosinophil                      |             1                       2              1                     |             
      Respiratory Epithelium, Hyperplasia  | 1              2        3                       1        2     3        1|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                           +           +        +         |             
      Cataract                             |                                           4                              |             
      Bilateral, Cataract                  |                                                                3         |             
      Retina, Degeneration                 |                                           4                              |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                           +                              |             
      Inflammation, Chronic, Multifocal    |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                                          |             
      Nephropathy, Chronic                 | 2  3  2     2  4  2  1  3  1  1  3  1  3  3  1        3  3  3     1  4  2|             
      Pigmentation, Diffuse                |       3              2              2           3     2     2            |             
      Pigmentation, Multifocal             |                         3                 1        2                     |             
      Bilateral, Hydronephrosis            |                                                                   2      |             
      Cortex, Hyperplasia, Atypical, Focal |    1                                                                     |             
      Cortex, Mineralization, Multifocal   |                                                                          |             
      Corticomedullary Junction,           |                                                                          |             
          Mineralization, Multifocal       |                               1                                          |             
      Pelvis, Inflammation, Diffuse,       |                                                                          |             
          Suppurative                      |                                                                      3   |             
      Transitional Epithelium, Hyperplasia |       2                                                                  |             
      Transitional Epithelium,             |                                                                          |             
          Mineralization, Focal            |                                                                          |             
      Transitional Epithelium,             |                                                                          |             
          Mineralization, Multifocal       |                                  1                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 4| 4| 7| 7| 7| 7| 7| 4| 6| 7| 7| 6| 4| 7| 6| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 4| 1| 3| 3| 3| 3| 3| 5| 0| 1| 3| 8| 9| 3| 9| 3| 3| 3| 8| 0| 3| 3|             
                                           | 0| 1| 1| 4| 4| 1| 1| 1| 0| 0| 6| 6| 4| 1| 1| 9| 1| 7| 1| 1| 0| 3| 9| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    300 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              | 3                                                              4         |             
      Inflammation, Chronic, Diffuse       |                                                                      2   |             
      Artery, Inflammation, Chronic Active,|                                                                          |             
           Multifocal                      |                                                                          |             
      Transitional Epithelium, Hyperplasia,|                                                                          |             
           Focal                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 6| 7| 4| 6| 7| 5| 7| 5| 6| 7| 7| 7| 7| 6| 7| 5| 7| 7| 5| 7| 5| 7|            |
                             DAY ON TEST   | 8| 3| 2| 4| 1| 3| 1| 2| 7| 2| 7| 3| 3| 3| 2| 0| 2| 2| 8| 2| 2| 2| 2| 0| 2|            |
                                           | 0| 0| 9| 6| 8| 4| 4| 9| 6| 8| 6| 7| 0| 0| 9| 9| 6| 9| 2| 8| 8| 6| 8| 6| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    300 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +|  46        |
      Inflammation, Chronic                | 1                                                                        |      1  1.0|
      Parasite Metazoan                    |                                  X           X                    X     X|      8     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |             X                          X           X        X  X         |      9     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Parasite Metazoan                    |                                                                         X|      3     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Muscularis, Fibrosis, Focal          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis, Focal                   |                                           2                              |      3  2.3|
      Angiectasis, Multifocal              |                                                                          |      1  3.0|
      Basophilic Focus                     |                                              X                           |      7     |
      Basophilic Focus, Multiple           |       X                             X  X                    X     X     X|     14     |
      Cytomegaly, Multifocal               | 1                                                                        |      1  1.0|
      Cytoplasmic Alteration, Focal        |                                                                          |      1  2.0|
      Fatty Change, Focal                  |                                                                          |      2  2.0|
      Fatty Change, Multifocal             | 1  2              1                                                      |      4  1.3|
      Granuloma, Multifocal                | 1     2           1  1  2                 1  1                       4   |     14  1.7|
      Hemorrhage, Acute, Multifocal        |                                  2                                       |      1  2.0|
      Hepatodiaphragmatic Nodule           |    X           X                 X                                       |      6     |
      Hyperplasia, Multifocal, Nodular     |                            3                                             |      2  2.0|
      Inflammation, Chronic, Multifocal    |                                                                          |      1  2.0|
      Mitotic Alteration                   |                            3                                             |      1  3.0|
      Mixed Cell Focus                     |                               X                                          |      3     |
      Mixed Cell Focus, Two                |                                                                          |      1     |
      Necrosis, Multifocal                 |    2           3                                                         |      5  2.0|
      Bile Duct, Hyperplasia, Multifocal   |             2                    3              2  2                     |      6  2.2|
      Centrilobular, Fatty Change, Diffuse |                                  4              3                        |      5  3.6|
      Centrilobular, Fatty Change,         |                                                                          |            |
          Multifocal                       |                                                       2                  |      1  2.0|
      Centrilobular, Necrosis, Diffuse     |                                                                          |      1  2.0|
      Centrilobular, Necrosis, Multifocal  |                                  2              2                        |      3  1.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  22                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 6| 7| 4| 6| 7| 5| 7| 5| 6| 7| 7| 7| 7| 6| 7| 5| 7| 7| 5| 7| 5| 7|            |
                             DAY ON TEST   | 8| 3| 2| 4| 1| 3| 1| 2| 7| 2| 7| 3| 3| 3| 2| 0| 2| 2| 8| 2| 2| 2| 2| 0| 2|            |
                                           | 0| 0| 9| 6| 8| 4| 4| 9| 6| 8| 6| 7| 0| 0| 9| 9| 6| 9| 2| 8| 8| 6| 8| 6| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    300 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Portal, Inflammation, Chronic,       |                                                                          |            |
          Multifocal                       |                                                                   2      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +  +                    +     +        +                              |   5        |
      Artery, Inflammation, Multifocal,    |                                                                          |            |
           Necrotizing                     |                                           4                              |      1  4.0|
      Fat, Inflammation, Focal, Necrotizing|                                           4                              |      1  4.0|
      Fat, Necrosis, Focal                 |    3  3                    3     3                                       |      4  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Focal, Granulomatous   |                                                                1         |      1  1.0|
      Acinus, Atrophy, Focal               |                                        2                                 |      2  2.0|
      Acinus, Atrophy, Multifocal          |                            2                          2           3      |      8  2.3|
      Duct, Cyst, Multiple                 |                                           2                              |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                +         |   1        |
      Mucosa, Palate, Inflammation,        |                                                                          |            |
          Chronic, Diffuse                 |                                                                4         |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  M  +     +  +  +  +  +  +  +  +  +  +  +|  47        |
      Parotid Gland, Inflammation, Chronic |                                                                          |            |
          Active, Focal                    |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic Active         |    3                                                                     |      1  3.0|
      Epithelium, Hyperplasia              |    3                                                                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                    +                     |   1        |
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Chronic, Diffuse                |                                                    3                     |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 1     2        3  2  2  2  2  1     1     3  2  2  2  2     1  1     2  1|     40  1.9|
      Artery, Inflammation, Chronic Active,|                                                                          |            |
           Focal                           |                                        3                                 |      1  3.0|
      Atrium Left, Thrombosis              |                                  3              2                        |      2  2.5|
      Epicardium, Inflammation, Chronic    |                                                                          |            |
          Active, Focal                    |                                                                   2      |      1  2.0|
      Myocardium, Degeneration, Focal      |    3                                                                     |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  23                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 6| 7| 4| 6| 7| 5| 7| 5| 6| 7| 7| 7| 7| 6| 7| 5| 7| 7| 5| 7| 5| 7|            |
                             DAY ON TEST   | 8| 3| 2| 4| 1| 3| 1| 2| 7| 2| 7| 3| 3| 3| 2| 0| 2| 2| 8| 2| 2| 2| 2| 0| 2|            |
                                           | 0| 0| 9| 6| 8| 4| 4| 9| 6| 8| 6| 7| 0| 0| 9| 9| 6| 9| 2| 8| 8| 6| 8| 6| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    300 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bilateral, Capsule, Fibrosis,        |                                                                          |            |
          Multifocal                       | 2                                                                        |      1  2.0|
      Capsule, Accessory Adrenal Cortical  |                                                                          |            |
          Nodule                           |                                                 X                        |      5     |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis, Multifocal              |             3     3                                                      |      4  2.8|
      Atrophy                              |                                                 2                        |      1  2.0|
      Congestion                           |                                        2                                 |      2  2.0|
      Degeneration, Diffuse, Fatty         |                                                                          |      1  3.0|
      Degeneration, Fatty, Focal           |                                        3  1        4                     |      8  2.6|
      Degeneration, Fatty, Multifocal      |                                                                          |      1  3.0|
      Hyperplasia, Focal                   |                                              3                          1|      2  2.0|
      Hyperplasia, Multifocal              |                                     2                                    |      1  2.0|
      Hypertrophy, Focal                   |                            2                                             |      1  2.0|
      Hypertrophy, Multifocal              |                                                                          |      1  3.0|
      Pigmentation, Diffuse, Hemosiderin   |                                  2                                       |      1  2.0|
      Pigmentation, Hemosiderin, Multifocal|             3                                                            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  45        |
      Angiectasis, Multifocal              |                                                                          |      1  3.0|
      Hyperplasia, Focal                   |                      2                                                   |      5  1.8|
      Hyperplasia, Multifocal              |                            2     1                                       |      3  1.7|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Focal                   |                   2                                                      |      4  2.0|
      Hypertrophy, Focal                   |                   3                                                      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M|  41        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Angiectasis, Focal    |                                              3                           |      2  2.5|
      Pars Distalis, Concretion            |                                                 2                        |      1  2.0|
      Pars Distalis, Cyst                  |                X           2        2  3  2     X  2     3               |     10  2.6|
      Pars Distalis, Hyperplasia, Focal    |                                        2                                 |      2  2.5|
      Pars Distalis, Hyperplasia           |                                                                          |      1  3.0|
      Pars Distalis, Hyperplasia,          |                                                                          |            |
          Multifocal                       |                                     2                                    |      1  2.0|
      Pars Nervosa, Pigmentation, Diffuse  |             3                                                            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1     |
      C-Cell, Hyperplasia, Focal           |       2                                                                  |      3  2.0|
      C-Cell, Hyperplasia, Multifocal      |                         1  2        2                 2              2   |      7  1.6|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 6| 7| 4| 6| 7| 5| 7| 5| 6| 7| 7| 7| 7| 6| 7| 5| 7| 7| 5| 7| 5| 7|            |
                             DAY ON TEST   | 8| 3| 2| 4| 1| 3| 1| 2| 7| 2| 7| 3| 3| 3| 2| 0| 2| 2| 8| 2| 2| 2| 2| 0| 2|            |
                                           | 0| 0| 9| 6| 8| 4| 4| 9| 6| 8| 6| 7| 0| 0| 9| 9| 6| 9| 2| 8| 8| 6| 8| 6| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    300 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Atrophy                              |                                  3                                       |      1  3.0|
      Ectasia                              | 3                       3                                         3      |      4  2.8|
      Hyperplasia                          |                                              4  3  4                     |      3  3.7|
      Inflammation, Acute                  | 2                                                                        |      1  2.0|
      Inflammation, Chronic Active         |                         2                                                |      2  2.0|
      Inflammation, Granulomatous          |                   2  2                                                  3|      3  2.3|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion, Diffuse                  |                                                                          |      1  2.0|
      Cyst                                 |       X                                                                  |      3     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenomyosis, Focal                   |                                                                          |      1  2.0|
      Cyst                                 |                                                    1                     |      1  1.0|
      Dilatation                           |                                                       3                  |      2  2.5|
      Inflammation, Chronic Active         |                                                       4                  |      1  4.0|
      Epithelium, Hyperplasia, Diffuse     |                                                                          |      1  2.0|
      Epithelium, Hyperplasia, Focal       |                                                                          |      1  4.0|
      Lumen, Hemorrhage                    |                         2                                                |      1  2.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  4.0|
      Hyperplasia, Megakaryocyte           | 3                                                                        |      1  3.0|
      Hyperplasia                          |                                        2  3                              |      2  2.5|
      Myeloid Cell, Hyperplasia            |                                                    2                     |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mediastinal, Hemorrhage              |                   3           3              3                           |      3  3.0|
      Mediastinal, Hyperplasia, Re Cell    |                                                                          |      1  2.0|
      Mediastinal, Pigmentation, Diffuse,  |                                                                          |            |
           Hemosiderin                     |                                                             3            |      1  3.0|
      Pancreatic, Pigmentation, Hemosiderin|                                                    3                     |      1  3.0|
      Renal, Hyperplasia, Plasma Cell      |                                                                          |      1  3.0|
      Renal, Hyperplasia, Re Cell          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Edema                                |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 6| 7| 4| 6| 7| 5| 7| 5| 6| 7| 7| 7| 7| 6| 7| 5| 7| 7| 5| 7| 5| 7|            |
                             DAY ON TEST   | 8| 3| 2| 4| 1| 3| 1| 2| 7| 2| 7| 3| 3| 3| 2| 0| 2| 2| 8| 2| 2| 2| 2| 0| 2|            |
                                           | 0| 0| 9| 6| 8| 4| 4| 9| 6| 8| 6| 7| 0| 0| 9| 9| 6| 9| 2| 8| 8| 6| 8| 6| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    300 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Lymphoid                |                                                                3         |      1  3.0|
      Hyperplasia, Plasma Cell             |                      2                                         3  3      |      5  3.0|
      Hyperplasia, Re Cell                 |                                                             2            |      1  2.0|
      Artery, Inflammation, Chronic Active,|                                                                          |            |
           Focal                           |                                                                3         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  46        |
      Hemorrhage                           |                   3                                                      |      2  3.0|
      Hyperplasia, Re Cell                 |                                        2                          2      |      3  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis, Focal                      |                                                 3                        |      2  2.5|
      Fibrosis, Multifocal                 |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     | 2     2        2                                                         |      5  2.2|
      Pigmentation, Hemosiderin            |                   2     2     2                       3     2  3  2      |     15  2.1|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  M  M  +  +  +  M  +  +  M  +  +  +  +  +  M  M  M  M|  37        |
      Hyperplasia, Diffuse, Tubular        |    2  3                       2           2                              |     14  2.4|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Ectasia, Diffuse                     |                                                                          |      1  3.0|
      Ectasia, Focal                       |                                                                          |      2  4.0|
      Ectasia, Multifocal                  | 2  3              2  2        2                 2                 1      |     15  2.2|
      Hyperplasia, Diffuse                 | 3  2     3              4                          2                 2   |     15  2.5|
      Hyperplasia, Focal                   |                                        2                                 |      2  3.0|
      Artery, Inflammation, Chronic Active,|                                                                          |            |
           Focal                           |                                        3                                 |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal, Squamous         |                                                                          |      1  4.0|
      Inflammation, Chronic Active, Focal  |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperostosis                         |                            2           2                                 |      2  2.0|
      Osteopetrosis                        |    2  3                                                                  |      5  3.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                +         |   1        |
      Inflammation, Diffuse, Proliferative |                                                                4         |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          | X        X        X     X     X                       X                  |     16  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  26                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 6| 7| 4| 6| 7| 5| 7| 5| 6| 7| 7| 7| 7| 6| 7| 5| 7| 7| 5| 7| 5| 7|            |
                             DAY ON TEST   | 8| 3| 2| 4| 1| 3| 1| 2| 7| 2| 7| 3| 3| 3| 2| 0| 2| 2| 8| 2| 2| 2| 2| 0| 2|            |
                                           | 0| 0| 9| 6| 8| 4| 4| 9| 6| 8| 6| 7| 0| 0| 9| 9| 6| 9| 2| 8| 8| 6| 8| 6| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    300 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hydrocephalus                        | 2                 2                                                      |      5  2.4|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  M  +  +  M  +  M  +  +  +  +  +  +  +  M  +  +  M  +  M  +|  40        |
      Hyperplasia, Focal, Papillary        |       2                                                                  |      1  2.0|
      Inflammation, Acute, Diffuse         |                   2                                                      |      1  2.0|
      Inflammation, Chronic, Focal         |       2                    2                                             |      3  1.7|
      Inflammation, Chronic Active, Focal  |                                                                          |      4  1.5|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atelectasis, Focal                   |                                                                          |      1  1.0|
      Inflammation, Chronic, Multifocal    |                                                                          |      1  3.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                          |      1  3.0|
      Bronchiole, Alveolus, Inflammation,  |                                                                          |            |
           Acute, Multifocal               |                                                                          |      1  3.0|
      Interstitium, Inflammation, Chronic, |                                                                          |            |
           Multifocal                      |                                        3                                 |      1  3.0|
      Pleura, Inflammation, Multifocal,    |                                                                          |            |
           Subacute                        |                                              2                           |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lumen, Exudate                       |                      1           2                                       |      2  1.5|
      Lumen, Foreign Body                  |                                                                   1      |      1  1.0|
      Mucosa, Inflammation, Acute          |                                  4                                       |      1  4.0|
      Mucosa, Inflammation, Chronic        |                               1                                          |      1  1.0|
      Mucosa, Inflammation, Chronic Active |                1                             1           1               |      4  1.0|
      Nasolacrimal Duct, Exudate           |                2                 1                                       |      4  1.8|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic                         | 1           2              2        1        1  1  1                     |     16  1.3|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic Active                  |                   1     3        2                                       |      4  2.3|
      Olfactory Epithelium, Atrophy        |          1        1                                         1            |      3  1.0|
      Olfactory Epithelium, Cyst           | 1           1                       2                 1           1      |     13  1.2|
      Olfactory Epithelium, Erosion        |                      1                                                   |      4  1.8|
      Olfactory Epithelium, Hyperplasia,   |                                                                          |            |
           Eosinophil                      |    2     1  1     3  1     2        3  1  1              1  3  1  1     2|     21  1.6|
      Respiratory Epithelium, Cyst         | 1           1           1                 1     1  1           1         |     10  1.0|
      Respiratory Epithelium, Hyperplasia, |                                                                          |            |
           Eosinophil                      |                                                                          |      3  1.3|
      Respiratory Epithelium, Hyperplasia  |    1              1           1     1  1     3  1     1  2               |     16  1.6|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  27                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 6| 7| 4| 6| 7| 5| 7| 5| 6| 7| 7| 7| 7| 6| 7| 5| 7| 7| 5| 7| 5| 7|            |
                             DAY ON TEST   | 8| 3| 2| 4| 1| 3| 1| 2| 7| 2| 7| 3| 3| 3| 2| 0| 2| 2| 8| 2| 2| 2| 2| 0| 2|            |
                                           | 0| 0| 9| 6| 8| 4| 4| 9| 6| 8| 6| 7| 0| 0| 9| 9| 6| 9| 2| 8| 8| 6| 8| 6| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    300 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +                             +                                          |   5        |
      Cataract                             |                                                                          |      1  4.0|
      Bilateral, Cataract                  |                                                                          |      1  3.0|
      Retina, Degeneration                 |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +                                                                        |   2        |
      Inflammation, Chronic, Multifocal    | 1                                                                        |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydronephrosis                       |                                              2                           |      1  2.0|
      Nephropathy, Chronic                 | 4  3  1  1  3     3  3  4  1  2  2  1  2  2  4     2  3  2  2  2  2     2|     43  2.3|
      Pigmentation, Diffuse                |             3              3     3              3  2                     |     11  2.5|
      Pigmentation, Multifocal             |    2                                         2                       2   |      6  2.0|
      Bilateral, Hydronephrosis            |                                                                          |      1  2.0|
      Cortex, Hyperplasia, Atypical, Focal |                                                                          |      1  1.0|
      Cortex, Mineralization, Multifocal   |                3                                                         |      1  3.0|
      Corticomedullary Junction,           |                                                                          |            |
          Mineralization, Multifocal       |                                                                          |      1  1.0|
      Pelvis, Inflammation, Diffuse,       |                                                                          |            |
          Suppurative                      |                                                                          |      1  3.0|
      Transitional Epithelium, Hyperplasia | 1  2                                                                     |      3  1.7|
      Transitional Epithelium,             |                                                                          |            |
          Mineralization, Focal            |                                     1                                    |      1  1.0|
      Transitional Epithelium,             |                                                                          |            |
          Mineralization, Multifocal       | 1  2                                                                     |      3  1.3|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  M  +  M  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Ectasia                              |                                                                          |      2  3.5|
      Inflammation, Chronic, Diffuse       |                                                                          |      1  2.0|
      Artery, Inflammation, Chronic Active,|                                                                          |            |
           Multifocal                      |                                        1                                 |      1  1.0|
      Transitional Epithelium, Hyperplasia,|                                                                          |            |
           Focal                           |                                                 3                        |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  28                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 5| 4| 7| 7| 4| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 3| 0| 3| 3| 3| 4| 9| 3| 3| 9| 5| 1| 3| 9| 3| 3| 3| 3| 0| 9| 3| 3| 2| 3| 3|             
                                           | 1| 1| 1| 1| 1| 8| 5| 1| 1| 9| 9| 4| 1| 3| 1| 1| 1| 1| 3| 6| 0| 0| 1| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    100 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                +  +        +                                      +      |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                +  +        +                                      +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                +  M        +                                      M      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                +  +        +                                      +      |             
      Parasite Metazoan                    |                   X                                                      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                +  +        +                                      +      |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                +  +        +                                      +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                +  +        +                                      +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                +  A        +                                      +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                +  A        +                                      +      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +     +  +  +  +  +  +  +  +  +     +  +     +     +  +        +  +   |             
      Angiectasis, Multifocal              |                                                                      3   |             
      Basophilic Focus                     |                X                                                         |             
      Basophilic Focus, Multiple           | X  X     X  X        X  X                       X                        |             
      Congestion, Acute, Multifocal        |                                                                      3   |             
      Fatty Change, Diffuse                |                                                                          |             
      Fatty Change, Multifocal             |                                  2                                       |             
      Granuloma, Multifocal                |                         2                       2        2               |             
      Hepatodiaphragmatic Nodule           |    X                    X                                                |             
      Hepatodiaphragmatic Nodule, Multiple |                                                          X               |             
      Hyperplasia, Focal, Nodular          |                                  2                                       |             
      Mitotic Alteration                   |                                                                      2   |             
      Necrosis, Focal                      |                                                                      1   |             
      Necrosis, Multifocal                 |                                        2                                 |             
      Pigmentation, Multifocal             |                                                                          |             
      Bile Duct, Hyperplasia, Multifocal   |                               2  2                                2      |             
      Centrilobular, Atrophy, Multifocal   |                                           3                              |             
      Centrilobular, Degeneration, Diffuse |                               2                                   2      |             
      Centrilobular, Degeneration,         |                                                                          |             
          Multifocal                       |                                  2                                       |             
      Centrilobular, Fatty Change, Diffuse |                            3           3                                 |             
      Periportal, Fatty Change, Multifocal | 2                                                                        |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                                                                     |             
                                            __________________________________________________________________________|             
   Pancreas                                |                +  +        +              +                       +     +|             
      Acinus, Atrophy, Multifocal          |                1                          2                              |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                +  +        +                                      +      |             
                                            __________________________________________________________________________|             
   Stomach                                 |                +  +        +                                      +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                +  +        +                                      +      |             
      Inflammation, Chronic Active         |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                +  +        +                                      +      |             
      Cyst Epithelial Inclusion            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 5| 4| 7| 7| 4| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 3| 0| 3| 3| 3| 4| 9| 3| 3| 9| 5| 1| 3| 9| 3| 3| 3| 3| 0| 9| 3| 3| 2| 3| 3|             
                                           | 1| 1| 1| 1| 1| 8| 5| 1| 1| 9| 9| 4| 1| 3| 1| 1| 1| 1| 3| 6| 0| 0| 1| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    100 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |          +     +  +        +                                      +      |             
      Cardiomyopathy                       |                2                                                         |             
      Atrium Left, Thrombosis              |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +        +     +  +        +                                      +     +|             
      Capsule, Accessory Adrenal Cortical  |                                                                          |             
          Nodule                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +        +     +  +        +                                      +     +|             
      Angiectasis, Multifocal              |                                                                         2|             
      Congestion                           |                   3                                                      |             
      Degeneration, Fatty, Focal           |                                                                          |             
      Degeneration, Fatty, Multifocal      | 2                                                                        |             
      Hyperplasia, Multifocal              |                                                                          |             
      Hypertrophy, Multifocal              |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +        +     +  +        +                                      +     +|             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                +  +        +              +                       +     +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                +  M        +                                      M      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +     +  +        +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis, Focal    |                               2                                          |             
      Pars Distalis, Angiectasis,          |                                                                          |             
          Multifocal                       |                                           2                              |             
      Pars Distalis, Cyst                  |       1                          3     3              4           4      |             
      Pars Distalis, Cyst, Multiple        |                                                             4            |             
      Pars Distalis, Hyperplasia, Focal    |                                                                         2|             
      Pars Distalis, Hyperplasia           |                                                                      3   |             
      Pars Distalis, Hyperplasia,          |                                                                          |             
          Multifocal                       |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                +  +        +           +                          +      |             
      Developmental Malformation           |                                                                          |             
      C-Cell, Hyperplasia, Multifocal      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Necrosis, Acute                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +     +     M  M     +  +                                      +      |             
      Abscess                              |                         3                                                |             
      Atrophy                              |    3                                                                     |             
      Ectasia                              |                            3                                             |             
      Hyperplasia                          |          4                                                               |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 5| 4| 7| 7| 4| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 3| 0| 3| 3| 3| 4| 9| 3| 3| 9| 5| 1| 3| 9| 3| 3| 3| 3| 0| 9| 3| 3| 2| 3| 3|             
                                           | 1| 1| 1| 1| 1| 8| 5| 1| 1| 9| 9| 4| 1| 3| 1| 1| 1| 1| 3| 6| 0| 0| 1| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    100 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |          +  +  +  +  +     +     +  +                             +      |             
      Cyst                                 |          X                       3  4                                    |             
                                            __________________________________________________________________________|             
   Uterus                                  |             +  +  +        +                 +              +  +  +      |             
      Dilatation                           |                3                                                         |             
      Lumen, Hemorrhage                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                +  +        +                                      +      |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +           +  +        +                          +  +  +     +      |             
      Pancreatic, Hemorrhage               |                                                                          |             
      Pancreatic, Inflammation, Acute      |                                                       2                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +              M  +        +                                      +      |             
      Hyperplasia, Re Cell                 |                   2                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +           +  +        M                             +  +     +      |             
      Hemorrhage                           | 2  2                                                        2            |             
      Pigmentation, Hemosiderin            |                   2                                                      |             
                                            __________________________________________________________________________|             
   Spleen                                  |                +  +        +  +  +        +           +           +      |             
      Fibrosis, Focal                      |                                           4                              |             
      Metaplasia, Focal, Osseous           |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |                +  +        +                                      M      |             
      Ectopic Parathyroid Gland            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +     +  +  +  +  +  +  +           +              +     +     M      |             
      Ectasia, Diffuse                     | 3                                                                        |             
      Ectasia, Multifocal                  |          1  2     2  2  3  3           2                                 |             
      Galactocele                          |             4                                                            |             
      Hyperplasia, Diffuse                 |    2                 2     3           2              2                  |             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |    +           +  +        +              +                       +      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                +  +        +                                      +      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                +  +        +  +                                   +      |             
      Compression                          |                                                                          |             
      Hemorrhage, Multifocal               |                   3                                                      |             
      Hydrocephalus                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  |                +  +        +                                      M      |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 5| 4| 7| 7| 4| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 3| 0| 3| 3| 3| 4| 9| 3| 3| 9| 5| 1| 3| 9| 3| 3| 3| 3| 0| 9| 3| 3| 2| 3| 3|             
                                           | 1| 1| 1| 1| 1| 8| 5| 1| 1| 9| 9| 4| 1| 3| 1| 1| 1| 1| 3| 6| 0| 0| 1| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    100 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Granuloma, Multifocal                |                                                                         1|             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |             1                                3                           |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Multifocal                      |          2                                                               |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Focal, Histiocyte               |                                                                          |             
      Interstitium, Inflammation, Chronic, |                                                                          |             
           Multifocal                      |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Exudate                       |          2                             1                                 |             
      Mucosa, Inflammation, Chronic        |                                                                          |             
      Mucosa, Inflammation, Chronic Active |                                                 1                    1   |             
      Mucosa, Thrombosis, Multifocal       |                               4        4                          1      |             
      Nasolacrimal Duct, Exudate           |                               2                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |          3  2        1                                2  1           2   |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic Active                  |                               3                                          |             
      Olfactory Epithelium, Atrophy        |                                                                          |             
      Olfactory Epithelium, Cyst           |                1                                1  1           1  1      |             
      Olfactory Epithelium, Erosion        |          1  1                                                            |             
      Olfactory Epithelium, Exudate        |                                                                          |             
      Olfactory Epithelium, Hyperplasia,   |                                                                          |             
           Eosinophil                      |             2                    1  1                          1         |             
      Olfactory Epithelium, Metaplasia     |                                                                          |             
      Respiratory Epithelium, Cyst         |    1                    1                                   1            |             
      Respiratory Epithelium, Hyperplasia  |       2     1                    1  1  1     1     1  1        1     1   |             
                                            __________________________________________________________________________|             
   Trachea                                 |                +  M        +                                      +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +                          +                                          |             
      Bilateral, Cataract                  |                                                                          |             
      Bilateral, Retina, Degeneration      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +              +  +        +           +              +           +      |             
      Nephropathy, Chronic                 | 4                                                     2                  |             
      Pigmentation, Diffuse                |                                                       3                  |             
      Pigmentation, Multifocal             |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                +  +        +                                      +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 5| 7| 5| 6| 6| 7| 7|            |
                             DAY ON TEST   | 2| 3| 6| 2| 2| 2| 0| 2| 2| 0| 2| 7| 3| 3| 2| 0| 6| 2| 2| 2| 8| 3| 3| 2| 2|            |
                                           | 4| 0| 1| 9| 9| 4| 7| 8| 8| 9| 8| 5| 0| 0| 9| 7| 0| 9| 6| 8| 3| 7| 7| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    100 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +              +                                +     +     +            |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +              +                                +     +     +  +         |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +              +                                +     M                  |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +              +                                +     +     +  +         |  10        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +              +                                +     +     +            |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +              +                                +     +     +            |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +              +                                +     +     +            |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | M              +                                +     +     +            |   7        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +              +                                +     M     +            |   7        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +     +  +  +        +     +        +  +  +  +  +  +  +            |  33        |
      Angiectasis, Multifocal              |                                              3                           |      2  3.0|
      Basophilic Focus                     | X  X                                                                     |      3     |
      Basophilic Focus, Multiple           |             X                                               X            |      9     |
      Congestion, Acute, Multifocal        |                                           2        2                     |      3  2.3|
      Fatty Change, Diffuse                |                   4                                                      |      1  4.0|
      Fatty Change, Multifocal             |                                                                          |      1  2.0|
      Granuloma, Multifocal                |    2        1                             3                              |      6  2.0|
      Hepatodiaphragmatic Nodule           |       X     X                                X                           |      5     |
      Hepatodiaphragmatic Nodule, Multiple |                                                                          |      1     |
      Hyperplasia, Focal, Nodular          |                                                          2               |      2  2.0|
      Mitotic Alteration                   |                                                                          |      1  2.0|
      Necrosis, Focal                      |                                                                          |      1  1.0|
      Necrosis, Multifocal                 |                                                                          |      1  2.0|
      Pigmentation, Multifocal             |                                           2                              |      1  2.0|
      Bile Duct, Hyperplasia, Multifocal   |                2           2                          2  2               |      7  2.0|
      Centrilobular, Atrophy, Multifocal   |                                                                          |      1  3.0|
      Centrilobular, Degeneration, Diffuse |                                  2                    3                  |      4  2.3|
      Centrilobular, Degeneration,         |                                                                          |            |
          Multifocal                       |                                                                          |      1  2.0|
      Centrilobular, Fatty Change, Diffuse |                                                          4               |      3  3.3|
      Periportal, Fatty Change, Multifocal |                                           2                              |      2  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                +         |   2        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +              +                                +     +  +  +  +         |  13        |
      Acinus, Atrophy, Multifocal          |                                                             1            |      3  1.3|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +              +                                +     +     +            |   9        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +              +                                +     +  +  +           +|  11        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +              +                                +     +  +  +           +|  11        |
      Inflammation, Chronic Active         |                                                          4               |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  33                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 5| 7| 5| 6| 6| 7| 7|            |
                             DAY ON TEST   | 2| 3| 6| 2| 2| 2| 0| 2| 2| 0| 2| 7| 3| 3| 2| 0| 6| 2| 2| 2| 8| 3| 3| 2| 2|            |
                                           | 4| 0| 1| 9| 9| 4| 7| 8| 8| 9| 8| 5| 0| 0| 9| 7| 0| 9| 6| 8| 3| 7| 7| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    100 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Epithelium, Hyperplasia              |                                                          1               |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +              +                                +     +  +  +           +|  11        |
      Cyst Epithelial Inclusion            |                                                                         2|      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +              +                                +     +     +            |  10        |
      Cardiomyopathy                       | 1                                                     1     1            |      4  1.3|
      Atrium Left, Thrombosis              |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +     +        +                                +  +  +     +            |  14        |
      Capsule, Accessory Adrenal Cortical  |                                                                          |            |
          Nodule                           |                                                       X                  |      1     |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +     +        +                                +  +  +     +            |  14        |
      Angiectasis, Multifocal              |                                                 3  2                     |      3  2.3|
      Congestion                           |                                                                          |      1  3.0|
      Degeneration, Fatty, Focal           |                                                             4            |      1  4.0|
      Degeneration, Fatty, Multifocal      |                                                                          |      1  2.0|
      Hyperplasia, Multifocal              |       3                                                                  |      1  3.0|
      Hypertrophy, Multifocal              |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +     +        +                                +  +  +     +            |  14        |
      Hyperplasia, Focal                   |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +              +                                +     +  +  +            |  12        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +              +                                +     +     +            |   7        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +     +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +  +  +  +  +|  43        |
      Pars Distalis, Angiectasis, Focal    |                                                                          |      1  2.0|
      Pars Distalis, Angiectasis,          |                                                                          |            |
          Multifocal                       |                                                       2                 3|      3  2.3|
      Pars Distalis, Cyst                  |                      2  2           2                 2     3            |     10  2.6|
      Pars Distalis, Cyst, Multiple        |                                                                          |      1  4.0|
      Pars Distalis, Hyperplasia, Focal    |                         2                                                |      2  2.0|
      Pars Distalis, Hyperplasia           |                                                                          |      1  3.0|
      Pars Distalis, Hyperplasia,          |                                                                          |            |
          Multifocal                       |                                     2                                    |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +              +                                +     +     +            |  10        |
      Developmental Malformation           |                                                       X                  |      1     |
      C-Cell, Hyperplasia, Multifocal      |                                                       1                  |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  34                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 5| 7| 5| 6| 6| 7| 7|            |
                             DAY ON TEST   | 2| 3| 6| 2| 2| 2| 0| 2| 2| 0| 2| 7| 3| 3| 2| 0| 6| 2| 2| 2| 8| 3| 3| 2| 2|            |
                                           | 4| 0| 1| 9| 9| 4| 7| 8| 8| 9| 8| 5| 0| 0| 9| 7| 0| 9| 6| 8| 3| 7| 7| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    100 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM - cont                |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                             +            |   1        |
      Necrosis, Acute                      |                                                             4            |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +     +        +                          +     M     +     M            |  11        |
      Abscess                              |                                                                          |      1  3.0|
      Atrophy                              |                                                                          |      1  3.0|
      Ectasia                              |                                                       2                  |      2  2.5|
      Hyperplasia                          |                                                                          |      1  4.0|
      Inflammation, Chronic Active         |                                           3                              |      1  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +     +        +        +                    +  +  +  +     +            |  18        |
      Cyst                                 |       4                                      4                           |      5  3.8|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +              +        +  +  +     +           +     +  +  +            |  18        |
      Dilatation                           |                                                       2     4            |      3  3.0|
      Lumen, Hemorrhage                    |                            4                                             |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +              +                                +     +     +            |   9        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +              +                 +              +     +  +  +  +         |  17        |
      Pancreatic, Hemorrhage               |                                  2                                       |      1  2.0|
      Pancreatic, Inflammation, Acute      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +              +                 +              +     +     +  +         |  11        |
      Hyperplasia, Re Cell                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +              +                                +     +     +            |  12        |
      Hemorrhage                           |                                                                          |      3  2.0|
      Pigmentation, Hemosiderin            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +              +  +        +     +              +  +  +  +  +  +         |  19        |
      Fibrosis, Focal                      |                                                                          |      1  4.0|
      Metaplasia, Focal, Osseous           |                                  3                                       |      1  3.0|
      Pigmentation, Hemosiderin            |                                                 2                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +              M                                M     +     +            |   6        |
      Ectopic Parathyroid Gland            |                                                       X     X            |      2     |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +     +  +     +     +  +        +  +  +  +  +  +  +           +|  29        |
      Ectasia, Diffuse                     |                2                                      2                  |      3  2.3|
      Ectasia, Multifocal                  |       4                          2           4                           |     10  2.5|
      Galactocele                          |                                                                          |      1  4.0|
      Hyperplasia, Diffuse                 |    1           2                          2     2  3                    2|     11  2.1|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  35                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 5| 7| 5| 6| 6| 7| 7|            |
                             DAY ON TEST   | 2| 3| 6| 2| 2| 2| 0| 2| 2| 0| 2| 7| 3| 3| 2| 0| 6| 2| 2| 2| 8| 3| 3| 2| 2|            |
                                           | 4| 0| 1| 9| 9| 4| 7| 8| 8| 9| 8| 5| 0| 0| 9| 7| 0| 9| 6| 8| 3| 7| 7| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    100 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Focal                   |                         3                                                |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +              +                                +     +     +     +     +|  13        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +              +                                +     +     +            |   9        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +              +                          +     +     +     +            |  11        |
      Compression                          |                                           X                              |      1     |
      Hemorrhage, Multifocal               |                                                                          |      1  3.0|
      Hydrocephalus                        |                                           2                              |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +              +                                +           M            |   6        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Granuloma, Multifocal                |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |             2           2              2                                 |      5  2.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Multifocal                      |                                                                          |      1  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Focal, Histiocyte               |             1                                                            |      1  1.0|
      Interstitium, Inflammation, Chronic, |                                                                          |            |
           Multifocal                      |                                                                         1|      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lumen, Exudate                       |    3                 1                                                   |      4  1.8|
      Mucosa, Inflammation, Chronic        |                                                             1           1|      2  1.0|
      Mucosa, Inflammation, Chronic Active |    3                                                              1      |      4  1.5|
      Mucosa, Thrombosis, Multifocal       |                                                          3               |      4  3.0|
      Nasolacrimal Duct, Exudate           |                                           2                       1      |      3  1.7|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic                         |    1  1  1  1  1  1                    2  3     2                 1  1   |     17  1.5|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic Active                  |                                                                          |      1  3.0|
      Olfactory Epithelium, Atrophy        |                                  1     1                                 |      2  1.0|
      Olfactory Epithelium, Cyst           |                                                                          |      5  1.0|
      Olfactory Epithelium, Erosion        |                      2                                                   |      3  1.3|
      Olfactory Epithelium, Exudate        |                            1                                             |      1  1.0|
      Olfactory Epithelium, Hyperplasia,   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  36                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 5| 7| 5| 6| 6| 7| 7|            |
                             DAY ON TEST   | 2| 3| 6| 2| 2| 2| 0| 2| 2| 0| 2| 7| 3| 3| 2| 0| 6| 2| 2| 2| 8| 3| 3| 2| 2|            |
                                           | 4| 0| 1| 9| 9| 4| 7| 8| 8| 9| 8| 5| 0| 0| 9| 7| 0| 9| 6| 8| 3| 7| 7| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    100 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
           Eosinophil                      | 1        1           3                    3                          2   |      9  1.7|
      Olfactory Epithelium, Metaplasia     |    3                                                                     |      1  3.0|
      Respiratory Epithelium, Cyst         |                      1           1                                1      |      6  1.0|
      Respiratory Epithelium, Hyperplasia  | 1  3  2     1  1  1                             1           1  1         |     19  1.2|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +              +                                +     +     +            |   8        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +                                                                        |   3        |
      Bilateral, Cataract                  | 4                                                                        |      1  4.0|
      Bilateral, Retina, Degeneration      | 4                                                                        |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +     +        +                                +     +  +  +            |  14        |
      Nephropathy, Chronic                 |       4        1                                4        3               |      6  3.0|
      Pigmentation, Diffuse                | 2                                                                        |      2  2.5|
      Pigmentation, Multifocal             |                                                          2               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +     +        +                                +     +     M            |   9        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  37                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 7| 6| 5| 0| 7| 6| 6| 6| 5| 7| 7| 3| 5| 7| 7| 4| 6| 7|             
                             DAY ON TEST   | 2| 2| 2| 3| 0| 2| 2| 2| 3| 2| 5| 1| 8| 2| 2| 1| 2| 0| 7| 1| 2| 2| 2| 5| 3|             
                                           | 9| 8| 8| 3| 6| 8| 8| 9| 8| 0| 7| 4| 3| 1| 3| 1| 9| 0| 1| 1| 9| 9| 2| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  M  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +  M  M  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  M  +  +  +  M  M     +  +     +  +  +  +  M  M  +  +  +  +  +|             
      Parasite Metazoan                    |                                                             X            |             
      Artery, Submucosa, Inflammation,     |                                                                          |             
           Chronic Active, Multifocal      |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +  M  +  +  +  +  +  +|             
      Inflammation, Chronic, Diffuse       |                                                                          |             
      Ulcer, Two                           |                                  3                                       |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  A  +     +  +     +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  A  +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   | 2                 2                                                      |             
      Angiectasis, Multifocal              |                      2                                                  2|             
      Basophilic Focus                     |    X                                                                     |             
      Basophilic Focus, Multiple           |                                                                          |             
      Cytoplasmic Alteration, Focal        | 2                                                              3         |             
      Degeneration, Ballooning, Focal      |                                           2                              |             
      Eosinophilic Focus                   |                                                                         X|             
      Eosinophilic Focus, Multiple         |       X                                                                  |             
      Fatty Change, Diffuse                |                                                    1                     |             
      Fatty Change, Focal                  |                                                             1            |             
      Fatty Change, Multifocal             |                                                                          |             
      Granuloma, Multifocal                |    3           1                                1        1               |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      |             2                                                            |             
      Hemorrhage, Multifocal               |          3                                                               |             
      Hepatodiaphragmatic Nodule           | X              X                                                         |             
      Hyperplasia, Multifocal, Nodular     |                                                                          |             
      Necrosis, Multifocal                 |          3              2        3                                   4   |             
      Thrombosis, Two                      |                                                                      X   |             
      Bile Duct, Fibrosis, Multifocal      |                                     2                                    |             
      Bile Duct, Hyperplasia, Multifocal   | 2     2  3     1        4        4  3           2  2     1  3  3     2   |             
      Centrilobular, Congestion, Diffuse   |                                              3                           |             
      Centrilobular, Degeneration, Diffuse |                                                                          |             
      Centrilobular, Fatty Change, Diffuse |                         3        4  3                             3      |             
      Centrilobular, Fatty Change,         |                                                                          |             
          Multifocal                       |                                                                          |             
      Centrilobular, Necrosis, Diffuse     |                                              1        2           3      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 7| 6| 5| 0| 7| 6| 6| 6| 5| 7| 7| 3| 5| 7| 7| 4| 6| 7|             
                             DAY ON TEST   | 2| 2| 2| 3| 0| 2| 2| 2| 3| 2| 5| 1| 8| 2| 2| 1| 2| 0| 7| 1| 2| 2| 2| 5| 3|             
                                           | 9| 8| 8| 3| 6| 8| 8| 9| 8| 0| 7| 4| 3| 1| 3| 1| 9| 0| 1| 1| 9| 9| 2| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Centrilobular, Necrosis, Multifocal  |                                                                          |             
      Periportal, Fatty Change, Diffuse    |                                                                          |             
      Portal, Inflammation, Chronic,       |                                                                          |             
          Multifocal                       |                                                                          |             
      Portal, Inflammation, Chronic Active,|                                                                          |             
           Multifocal                      |                                                    2                     |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                  +  +                       +        +   |             
      Hemorrhage, Acute, Multifocal        |                                     4                                    |             
      Artery, Inflammation, Chronic,       |                                                                          |             
          Multifocal                       |                                                             4            |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                            1                                             |             
      Acinus, Atrophy, Diffuse             | 2                                                                        |             
      Acinus, Atrophy, Focal               |    2                 2                                                  2|             
      Acinus, Atrophy, Multifocal          |       2  2  1           4  2              3  3                       4   |             
      Acinus, Hyperplasia, Multifocal      |                                                                          |             
      Artery, Inflammation, Chronic Active,|                                                                          |             
           Multifocal                      |                                                             3            |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                     +                                    |             
      Palate, Inflammation, Chronic, Focal |                                     2                                    |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation, Chronic Active,|                                                                          |             
           Multifocal                      |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |          4                       1                 4                 3   |             
      Ulcer                                |          3           4                                               4   |             
      Epithelium, Hyperplasia              |                                  2                 3                 3   |             
      Submucosa, Inflammation, Subacute    |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst, Multiple                       |                                                                          |             
      Mineralization, Multifocal           |                                                    2                     |             
      Ulcer, Acute                         |                         3                                                |             
                                            __________________________________________________________________________|             
   Tooth                                   |                      +                       +                           |             
      Pulp, Angiectasis                    |                      4                                                   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 3  3  3     2  2  2  2  2  3     2  2  3  2  2  2  3  1  2  2  2     2  2|             
      Atrium Left, Thrombosis              |                         3        3                                       |             
      Endocardium, Atrium, Fibrosis, Focal |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 7| 6| 5| 0| 7| 6| 6| 6| 5| 7| 7| 3| 5| 7| 7| 4| 6| 7|             
                             DAY ON TEST   | 2| 2| 2| 3| 0| 2| 2| 2| 3| 2| 5| 1| 8| 2| 2| 1| 2| 0| 7| 1| 2| 2| 2| 5| 3|             
                                           | 9| 8| 8| 3| 6| 8| 8| 9| 8| 0| 7| 4| 3| 1| 3| 1| 9| 0| 1| 1| 9| 9| 2| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Valve, Fibrosis, Focal               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Accessory Adrenal Cortical  |                                                                          |             
          Nodule                           |                            X                                             |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cytoplasmic Alteration, Focal        |                                                                          |             
      Degeneration, Diffuse, Fatty         |          2                          1     1        2              2  3   |             
      Degeneration, Fatty, Focal           |    2                    2           2           2                       3|             
      Degeneration, Fatty, Multifocal      |                                                    2           2         |             
      Hyperplasia, Focal                   |       3                                                                  |             
      Hyperplasia, Multifocal              |                      2           3                                   2   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                                                                          |             
      Hyperplasia, Focal                   |                      2  2        2        3                 3            |             
      Hyperplasia, Multifocal              | 2        2        2                 1              3                    2|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Atrophy, Diffuse                     |                                                                          |             
      Hyperplasia, Focal                   |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Hyperplasia, Multifocal              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +     +  +  +  M  +  +  +  +  +  +  +  +  M  +|             
      Hyperplasia                          |                                                    2                     |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                  2                                   3   |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia, Diffuse, |                                                                          |             
           Eosinophil                      |                      3                                                   |             
      Pars Distalis, Hyperplasia, Focal    |                         3                                                |             
      Pars Distalis, Hyperplasia,          |                                                                          |             
          Multifocal                       |             2        2                                               2   |             
      Pars Distalis, Pigmentation, Focal   |                         3                                                |             
      Pars Intermedia, Hyperplasia         |                                                                3         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                       X                  |             
      Mineralization, Multifocal           |                                                                          |             
      C-Cell, Hyperplasia, Focal           |                                                                          |             
      C-Cell, Hyperplasia, Multifocal      |                         4                                                |             
      Follicular Cell, Degeneration,       |                                                                          |             
          Multifocal                       |                                                 1                        |             
      Follicular Cell, Hyperplasia, Focal  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 7| 6| 5| 0| 7| 6| 6| 6| 5| 7| 7| 3| 5| 7| 7| 4| 6| 7|             
                             DAY ON TEST   | 2| 2| 2| 3| 0| 2| 2| 2| 3| 2| 5| 1| 8| 2| 2| 1| 2| 0| 7| 1| 2| 2| 2| 5| 3|             
                                           | 9| 8| 8| 3| 6| 8| 8| 9| 8| 0| 7| 4| 3| 1| 3| 1| 9| 0| 1| 1| 9| 9| 2| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM - cont                |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation, Multifocal               |                                                                      2   |             
      Granuloma Sperm, Single              |                                                                          |             
      Inflammation, Focal, Suppurative     |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +     M  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Atrophy, Diffuse                     |                                                                          |             
      Ectasia                              |             2                                                            |             
      Fibrosis, Diffuse                    |                                                                          |             
      Inflammation, Chronic Active         |             2                                   1                        |             
      Inflammation, Diffuse, Granulomatous |                                                                      2   |             
      Inflammation, Focal, Granulomatous   | 2                                                        2               |             
      Inflammation, Focal, Suppurative     |                2                                                         |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |          3        2     2           2              3           1         |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                      1                 1  1                    2         |             
      Hyperplasia, Multifocal              | 2                                                                        |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |             3                                      4     3        2      |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  M     +  +  +  M     +  +  +  +  +  +  +  +  M  +  +  M  +  +|             
      Atrophy, Diffuse                     |                                     2                                    |             
      Inflammation, Diffuse, Subacute      |                                                    3                     |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization, Focal                |                                              1                           |             
      Mineralization, Multifocal           |                                                                          |             
      Arteriole, Inflammation              |                2                          1     3  3                     |             
      Interstitial Cell, Hyperplasia       |                                                                          |             
      Seminiferous Tubule, Atrophy         |       4  1              1              1           3                     |             
      Seminiferous Tubule, Degeneration    |                                                                          |             
      Serosa, Necrosis, Focal              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             3  2  3                                               3      |             
      Metaplasia, Osseous                  |                                                                          |             
      Myelofibrosis                        |                                                                          |             
      Myeloid Cell, Hyperplasia            |                                                    3                     |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Focal, Suppurative     |                                                                      3   |             
      Lumbar, Inflammation, Granulomatous, |                                                                          |             
           Multifocal                      |                3                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 7| 6| 5| 0| 7| 6| 6| 6| 5| 7| 7| 3| 5| 7| 7| 4| 6| 7|             
                             DAY ON TEST   | 2| 2| 2| 3| 0| 2| 2| 2| 3| 2| 5| 1| 8| 2| 2| 1| 2| 0| 7| 1| 2| 2| 2| 5| 3|             
                                           | 9| 8| 8| 3| 6| 8| 8| 9| 8| 0| 7| 4| 3| 1| 3| 1| 9| 0| 1| 1| 9| 9| 2| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                                  2                                       |             
      Mediastinal, Hyperplasia, Re Cell    |                                                                          |             
      Mediastinal, Pigmentation,           |                                                                          |             
          Hemosiderin                      |                                                                          |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                             2            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Hyperplasia, Lymphoid                | 2                                                                        |             
      Hyperplasia, Plasma Cell             |             4                                                            |             
      Hyperplasia, Re Cell                 |                                        3                                 |             
      Inflammation, Focal, Subacute        |                                                    2                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  M  +  +  +  +  M     +  +  +  M  +  +  +  M  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Re Cell                 |                                        3                                 |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |                                                                          |             
      Fibrosis, Multifocal                 | 2              2                                                         |             
      Hematopoietic Cell Proliferation     |             2                                      1  4                  |             
      Necrosis, Coagulative, Focal         |                                  3                                       |             
      Pigmentation, Hemosiderin            |                                        2                 2               |             
      Capsule, Fibrosis, Multifocal        |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  M  +  +  +     +  M  +  M  +  +  +  +  +  +  +  M  M  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Tubular                 | 2                                2                 2           3         |             
      Artery, Inflammation, Chronic Active |                                                             4            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  M  +  +  M  M  +  +|             
      Ectasia, Diffuse                     |    3                             3  3              4     2              2|             
      Ectasia, Multifocal                  | 2     2        4  3     3  3           2  1  4  2                    4   |             
      Hyperplasia, Diffuse                 |                3     2                                                   |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                2                                                         |             
      Inflammation, Proliferative          |                   3                                      2               |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia, Squamous                |                                                                          |             
      Inflammation, Chronic, Focal         |                                                                          |             
      Artery, Subcutaneous Tissue,         |                                                                          |             
          Inflammation, Chronic Active,    |                                                                          |             
           Focal                           |                                                                          |             
      Subcutaneous Tissue, Hemorrhage,     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 7| 6| 5| 0| 7| 6| 6| 6| 5| 7| 7| 3| 5| 7| 7| 4| 6| 7|             
                             DAY ON TEST   | 2| 2| 2| 3| 0| 2| 2| 2| 3| 2| 5| 1| 8| 2| 2| 1| 2| 0| 7| 1| 2| 2| 2| 5| 3|             
                                           | 9| 8| 8| 3| 6| 8| 8| 9| 8| 0| 7| 4| 3| 1| 3| 1| 9| 0| 1| 1| 9| 9| 2| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
           Chronic, Focal                  |                                                       4                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sternum, Developmental Malformation  |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |    3  1                    4                    3  X     X              2|             
      Hemorrhage, Focal                    |          4                                         3                     |             
      Hemorrhage, Multifocal               |                                     4                                    |             
      Hydrocephalus                        |                            4                 2                           |             
      Thalamus, Gliosis, Focal             |                3                                                         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  M  +  +  +  +  M     +  +  +  +  M  +  +  M  M  +  +  M  +  +|             
      Inflammation, Chronic Active, Focal  |       3        2        1                                      2     4   |             
      Inflammation, Focal, Suppurative     |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema, Focal                         |                                                                          |             
      Hemorrhage, Multifocal, Subacute     |                                                       3                  |             
      Bronchus, Epithelium, Hyperplasia,   |                                                                          |             
           Focal                           |                                                                          |             
      Interstitium, Inflammation, Chronic, |                                                                          |             
           Focal                           |                                                             1            |             
      Interstitium, Inflammation, Chronic, |                                                                          |             
           Multifocal                      |                                                                          |             
      Vein, Mineralization, Multifocal     |                                              3                           |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Exudate                       |                         2                          1                     |             
      Lumen, Foreign Body                  |                   2                                                      |             
      Mucosa, Inflammation, Chronic        |                                              1  1  2                     |             
      Mucosa, Inflammation, Chronic Active |                   2     2                                                |             
      Mucosa, Thrombosis, Multifocal       |                         4        2                                3      |             
      Nasolacrimal Duct, Exudate           |                                                                          |             
      Nasolacrimal Duct, Hyperplasia       |                                                                         2|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         | 2           4           2  3        1        1     1              1      |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic Active                  |                                                                          |             
      Olfactory Epithelium, Atrophy        |                                                                          |             
      Olfactory Epithelium, Hyperplasia,   |                                                                          |             
           Eosinophil                      |                                     2                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 7| 6| 5| 0| 7| 6| 6| 6| 5| 7| 7| 3| 5| 7| 7| 4| 6| 7|             
                             DAY ON TEST   | 2| 2| 2| 3| 0| 2| 2| 2| 3| 2| 5| 1| 8| 2| 2| 1| 2| 0| 7| 1| 2| 2| 2| 5| 3|             
                                           | 9| 8| 8| 3| 6| 8| 8| 9| 8| 0| 7| 4| 3| 1| 3| 1| 9| 0| 1| 1| 9| 9| 2| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Respiratory Epithelium, Cyst         |                                                                          |             
      Respiratory Epithelium, Hyperplasia, |                                                                          |             
           Eosinophil                      |                                     1     2                              |             
      Respiratory Epithelium, Hyperplasia  | 1                       2        1              2  2                     |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Artery, Inflammation, Chronic Active,|                                                                          |             
           Focal                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |          +                          +        +                           |             
      Choroid, Left, Hemorrhage            |          4                                                               |             
      Retina, Degeneration                 |                                     2                                    |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 4  4  3  3  2  4  4  4  1  2     3  3  1  4  3  4  4     4  3  4  2  3  4|             
      Pigmentation, Diffuse                |                                     3                                    |             
      Pigmentation, Multifocal             |                            2                                             |             
      Cortex, Cyst                         |                                                                      2   |             
      Cortex, Hyperplasia, Atypical        |                                                                          |             
      Transitional Epithelium, Hyperplasia |                      3                                                   |             
      Transitional Epithelium,             |                                                                          |             
          Mineralization                   |          1           2           2                                       |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Gross Observation           |                                                             X            |             
      Inflammation, Chronic Active, Focal  |                                                    2                     |             
      Lumen, Calculus Micro Observation    |                                                                          |             
          Only, Single                     |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 6| 7| 7| 5| 6| 6| 7| 5| 5| 5| 5| 7| 7| 7| 7| 6| 4| 7| 6| 7| 6| 7|            |
                             DAY ON TEST   | 0| 1| 7| 4| 2| 2| 3| 2| 5| 3| 5| 9| 5| 2| 3| 2| 2| 2| 9| 9| 2| 4| 3| 9| 3|            |
                                           | 7| 3| 3| 3| 9| 9| 2| 3| 8| 0| 7| 9| 3| 5| 0| 9| 9| 9| 3| 2| 1| 7| 0| 7| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | M  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +|  43        |
      Parasite Metazoan                    |    X                                                              X      |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +|  46        |
      Parasite Metazoan                    |    X        X                                         X           X      |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | M  M  M  +  +  +  M  +  +  +  +  +  +     M  +  +  +  +     +  +  +  +  +|  36        |
      Parasite Metazoan                    |             X                                                            |      2     |
      Artery, Submucosa, Inflammation,     |                                                                          |            |
           Chronic Active, Multifocal      |                            2                                             |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +|  45        |
      Inflammation, Chronic, Diffuse       |                                              2                           |      1  2.0|
      Ulcer, Two                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis, Focal                   |    2                                                                     |      3  2.0|
      Angiectasis, Multifocal              |                                                 2                        |      3  2.0|
      Basophilic Focus                     |                                                                          |      1     |
      Basophilic Focus, Multiple           |                X                                                         |      1     |
      Cytoplasmic Alteration, Focal        |                                                                          |      2  2.5|
      Degeneration, Ballooning, Focal      |                      2     2                                             |      3  2.0|
      Eosinophilic Focus                   |                                                                          |      1     |
      Eosinophilic Focus, Multiple         |                                                                          |      1     |
      Fatty Change, Diffuse                |                                                                          |      1  1.0|
      Fatty Change, Focal                  |                1                                                         |      2  1.0|
      Fatty Change, Multifocal             |                                  2                                       |      1  2.0|
      Granuloma, Multifocal                |                                                                          |      4  1.5|
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Multifocal                      |                                                                          |      1  2.0|
      Hemorrhage, Multifocal               |                         3                                                |      2  3.0|
      Hepatodiaphragmatic Nodule           |    X                                                                     |      3     |
      Hyperplasia, Multifocal, Nodular     |                                                    4                     |      1  4.0|
      Necrosis, Multifocal                 |    2  2              1  3           2           2     1  2               |     12  2.3|
      Thrombosis, Two                      |                                                                          |      1     |
      Bile Duct, Fibrosis, Multifocal      |                         3                                                |      2  2.5|
      Bile Duct, Hyperplasia, Multifocal   |    4  3  1  4  2     4  3  3     1  3     2  3     4  3     3  2  1  2  3|     32  2.6|
      Centrilobular, Congestion, Diffuse   |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  45                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 6| 7| 7| 5| 6| 6| 7| 5| 5| 5| 5| 7| 7| 7| 7| 6| 4| 7| 6| 7| 6| 7|            |
                             DAY ON TEST   | 0| 1| 7| 4| 2| 2| 3| 2| 5| 3| 5| 9| 5| 2| 3| 2| 2| 2| 9| 9| 2| 4| 3| 9| 3|            |
                                           | 7| 3| 3| 3| 9| 9| 2| 3| 8| 0| 7| 9| 3| 5| 0| 9| 9| 9| 3| 2| 1| 7| 0| 7| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Centrilobular, Degeneration, Diffuse |    2                                                        3            |      2  2.5|
      Centrilobular, Fatty Change, Diffuse |                      4              3  4              4  4     2     4   |     11  3.5|
      Centrilobular, Fatty Change,         |                                                                          |            |
          Multifocal                       |       3                                                                  |      1  3.0|
      Centrilobular, Necrosis, Diffuse     | 3                                      3                                 |      5  2.4|
      Centrilobular, Necrosis, Multifocal  |                                                                      2   |      1  2.0|
      Periportal, Fatty Change, Diffuse    |                                                 3                        |      1  3.0|
      Portal, Inflammation, Chronic,       |                                                                          |            |
          Multifocal                       |                                  1                                       |      1  1.0|
      Portal, Inflammation, Chronic Active,|                                                                          |            |
           Multifocal                      |                                              2                           |      2  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                    +  +        +        +|   8        |
      Hemorrhage, Acute, Multifocal        |                                                                          |      1  4.0|
      Artery, Inflammation, Chronic,       |                                                                          |            |
          Multifocal                       |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  M  +  +  +  +  +|  46        |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                              2                           |      1  2.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                   1                                                      |      2  1.0|
      Acinus, Atrophy, Diffuse             |                                     4              4                     |      3  3.3|
      Acinus, Atrophy, Focal               |             2     1                                                      |      5  1.8|
      Acinus, Atrophy, Multifocal          | 2        1     1        4     3  2              2     2              1  2|     18  2.3|
      Acinus, Hyperplasia, Multifocal      |                      1                                                   |      1  1.0|
      Artery, Inflammation, Chronic Active,|                                                                          |            |
           Multifocal                      |                            2                                             |      2  2.5|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
      Palate, Inflammation, Chronic, Focal |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Artery, Inflammation, Chronic Active,|                                                                          |            |
           Multifocal                      |                            2                                             |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|  48        |
      Inflammation, Chronic Active         |                                                                      2   |      5  2.8|
      Ulcer                                |                                                                          |      3  3.7|
      Epithelium, Hyperplasia              |                                                 3  3                 3   |      6  2.8|
      Submucosa, Inflammation, Subacute    |                                                 4                        |      1  4.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +|  47        |
      Cyst, Multiple                       |       2                                                                  |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  46                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 6| 7| 7| 5| 6| 6| 7| 5| 5| 5| 5| 7| 7| 7| 7| 6| 4| 7| 6| 7| 6| 7|            |
                             DAY ON TEST   | 0| 1| 7| 4| 2| 2| 3| 2| 5| 3| 5| 9| 5| 2| 3| 2| 2| 2| 9| 9| 2| 4| 3| 9| 3|            |
                                           | 7| 3| 3| 3| 9| 9| 2| 3| 8| 0| 7| 9| 3| 5| 0| 9| 9| 9| 3| 2| 1| 7| 0| 7| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Mineralization, Multifocal           |                                                                          |      1  2.0|
      Ulcer, Acute                         |                                                       2                  |      2  2.5|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   2        |
      Pulp, Angiectasis                    |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cardiomyopathy                       | 4     2  3  4  1  1  1  2  2  1  3  2  4        3        2  2  3  2  2  1|     42  2.2|
      Atrium Left, Thrombosis              |                                        3           2                     |      4  2.8|
      Endocardium, Atrium, Fibrosis, Focal |                                              2                           |      1  2.0|
      Valve, Fibrosis, Focal               |                                                                      3   |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Capsule, Accessory Adrenal Cortical  |                                                                          |            |
          Nodule                           |       X              X           X                    X                  |      5     |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cytoplasmic Alteration, Focal        |                                           2                              |      1  2.0|
      Degeneration, Diffuse, Fatty         |                      2              3  3        2  2  3              3   |     13  2.2|
      Degeneration, Fatty, Focal           |                            2                                             |      6  2.2|
      Degeneration, Fatty, Multifocal      |       1                                                                  |      3  1.7|
      Hyperplasia, Focal                   |          2                          1                             2      |      4  2.0|
      Hyperplasia, Multifocal              |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis, Focal                   |                                                    2                     |      1  2.0|
      Hyperplasia, Focal                   |    2                       2                                            2|      8  2.3|
      Hyperplasia, Multifocal              |                2        1                          2        3            |     10  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  M  +  +  +  +  +|  46        |
      Atrophy, Diffuse                     |                                                    4                     |      1  4.0|
      Hyperplasia, Focal                   |                                     3                             2      |      2  2.5|
      Hyperplasia                          |                            3                                             |      1  3.0|
      Hyperplasia, Multifocal              |                                                 3                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  45        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Angiectasis           |                                                                          |      2  2.5|
      Pars Distalis, Cyst                  |                         3                                                |      1  3.0|
      Pars Distalis, Hyperplasia, Diffuse, |                                                                          |            |
           Eosinophil                      |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  47                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 6| 7| 7| 5| 6| 6| 7| 5| 5| 5| 5| 7| 7| 7| 7| 6| 4| 7| 6| 7| 6| 7|            |
                             DAY ON TEST   | 0| 1| 7| 4| 2| 2| 3| 2| 5| 3| 5| 9| 5| 2| 3| 2| 2| 2| 9| 9| 2| 4| 3| 9| 3|            |
                                           | 7| 3| 3| 3| 9| 9| 2| 3| 8| 0| 7| 9| 3| 5| 0| 9| 9| 9| 3| 2| 1| 7| 0| 7| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Hyperplasia, Focal    |          2                                                               |      2  2.5|
      Pars Distalis, Hyperplasia,          |                                                                          |            |
          Multifocal                       |                                                    2                 2   |      5  2.0|
      Pars Distalis, Pigmentation, Focal   |                                                                          |      1  3.0|
      Pars Intermedia, Hyperplasia         |             2                                                            |      2  2.5|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                                                          |      1     |
      Mineralization, Multifocal           |                                        2                                 |      1  2.0|
      C-Cell, Hyperplasia, Focal           |             3                                   3  2                 2   |      4  2.5|
      C-Cell, Hyperplasia, Multifocal      |                2                 2                          2            |      4  2.5|
      Follicular Cell, Degeneration,       |                                                                          |            |
          Multifocal                       |                                                                          |      1  1.0|
      Follicular Cell, Hyperplasia, Focal  |                                                 3                        |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  47        |
      Dilatation, Multifocal               |                               2                                          |      2  2.0|
      Granuloma Sperm, Single              |                         4                                                |      1  4.0|
      Inflammation, Focal, Suppurative     |                         3                                                |      1  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  46        |
      Atrophy, Diffuse                     |                                                    3                     |      1  3.0|
      Ectasia                              |                3                                                         |      2  2.5|
      Fibrosis, Diffuse                    |                         3              4                                 |      2  3.5|
      Inflammation, Chronic Active         |                   3                    3                                 |      4  2.3|
      Inflammation, Diffuse, Granulomatous |                                                                          |      1  2.0|
      Inflammation, Focal, Granulomatous   |       2                       2                                          |      4  2.0|
      Inflammation, Focal, Suppurative     |                                                                          |      1  2.0|
      Inflammation, Granulomatous,         |                                                                          |            |
          Multifocal                       |    2     2  2              2     2        3  3  3     2        2     2  2|     18  2.2|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Focal                   |                                                                      1   |      5  1.2|
      Hyperplasia, Multifocal              |    2                                               1                     |      3  1.7|
      Inflammation, Chronic                |                      2                                                   |      1  2.0|
      Inflammation, Chronic Active         |    2  2                    2  2                                          |      8  2.5|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +|  41        |
      Atrophy, Diffuse                     |                         2                                               3|      3  2.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  48                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 6| 7| 7| 5| 6| 6| 7| 5| 5| 5| 5| 7| 7| 7| 7| 6| 4| 7| 6| 7| 6| 7|            |
                             DAY ON TEST   | 0| 1| 7| 4| 2| 2| 3| 2| 5| 3| 5| 9| 5| 2| 3| 2| 2| 2| 9| 9| 2| 4| 3| 9| 3|            |
                                           | 7| 3| 3| 3| 9| 9| 2| 3| 8| 0| 7| 9| 3| 5| 0| 9| 9| 9| 3| 2| 1| 7| 0| 7| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Diffuse, Subacute      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Mineralization, Focal                |                                                                          |      1  1.0|
      Mineralization, Multifocal           |                   2                                                      |      1  2.0|
      Arteriole, Inflammation              |                3                                3                        |      6  2.5|
      Interstitial Cell, Hyperplasia       |    1                                                                 1   |      2  1.0|
      Seminiferous Tubule, Atrophy         |       2     3                    1              3  3  3  4     3         |     13  2.5|
      Seminiferous Tubule, Degeneration    |                2        3                                                |      2  2.5|
      Serosa, Necrosis, Focal              |                                                 3                        |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |    3                                   4                 3     4         |      8  3.1|
      Metaplasia, Osseous                  |                                                       2                  |      1  2.0|
      Myelofibrosis                        |                                                       3                  |      1  3.0|
      Myeloid Cell, Hyperplasia            |          3        4  3                                                   |      4  3.3|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Focal, Suppurative     |                                                                          |      1  3.0|
      Lumbar, Inflammation, Granulomatous, |                                                                          |            |
           Multifocal                      |                                                                          |      1  3.0|
      Mediastinal, Hemorrhage              | 3                                            4                           |      2  3.5|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  2.0|
      Mediastinal, Hyperplasia, Re Cell    |                            3                                             |      1  3.0|
      Mediastinal, Pigmentation,           |                                                                          |            |
          Hemosiderin                      |                                        3                       2         |      2  2.5|
      Pancreatic, Hyperplasia, Lymphoid    |                                        3                                 |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +|  44        |
      Hyperplasia, Lymphoid                |                                                                2         |      2  2.0|
      Hyperplasia, Plasma Cell             |          3                                                               |      2  3.5|
      Hyperplasia, Re Cell                 |                                                                          |      1  3.0|
      Inflammation, Focal, Subacute        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  44        |
      Depletion Lymphoid                   |                      3                                                   |      1  3.0|
      Hyperplasia, Lymphoid                |                                        3                       2         |      2  2.5|
      Hyperplasia, Re Cell                 |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Fibrosis, Focal                      |                                                             3            |      1  3.0|
      Fibrosis, Multifocal                 |                                                                          |      2  2.0|
      Hematopoietic Cell Proliferation     |                                                                3         |      4  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  49                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 6| 7| 7| 5| 6| 6| 7| 5| 5| 5| 5| 7| 7| 7| 7| 6| 4| 7| 6| 7| 6| 7|            |
                             DAY ON TEST   | 0| 1| 7| 4| 2| 2| 3| 2| 5| 3| 5| 9| 5| 2| 3| 2| 2| 2| 9| 9| 2| 4| 3| 9| 3|            |
                                           | 7| 3| 3| 3| 9| 9| 2| 3| 8| 0| 7| 9| 3| 5| 0| 9| 9| 9| 3| 2| 1| 7| 0| 7| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Necrosis, Coagulative, Focal         |                                                                          |      1  3.0|
      Pigmentation, Hemosiderin            |                                  2                                       |      3  2.0|
      Capsule, Fibrosis, Multifocal        |                            2                                             |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  M  M  +  +  M  +  M  +  +  +|  38        |
      Hemorrhage                           | 3                                                                        |      1  3.0|
      Hyperplasia, Tubular                 |             2  3           3  2                                          |      8  2.4|
      Artery, Inflammation, Chronic Active |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  +  M  +  +  M  +  +  +  +  M  M  +  +  +  +  +  +  M  +  M  +  +  +|  38        |
      Ectasia, Diffuse                     |                3                                      3              1   |      9  2.7|
      Ectasia, Multifocal                  |       2              2                          2                        |     14  2.6|
      Hyperplasia, Diffuse                 |                                                             3            |      3  2.7|
      Inflammation, Chronic Active,        |                                                                          |            |
          Multifocal                       |       2                                                                  |      2  2.0|
      Inflammation, Proliferative          |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst Epithelial Inclusion            |                                                          X               |      1     |
      Hyperkeratosis                       |                                                 3                        |      1  3.0|
      Hyperplasia, Squamous                |                                                                   2      |      1  2.0|
      Inflammation, Chronic, Focal         |                                                                   2      |      1  2.0|
      Artery, Subcutaneous Tissue,         |                                                                          |            |
          Inflammation, Chronic Active,    |                                                                          |            |
           Focal                           |                            2                                             |      1  2.0|
      Subcutaneous Tissue, Hemorrhage,     |                                                                          |            |
           Chronic, Focal                  |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Sternum, Developmental Malformation  |                                                    X                     |      1     |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                          +     +         |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Compression                          |       X        X                 X              2                        |     11  2.6|
      Hemorrhage, Focal                    |    2                                                                 1   |      4  2.5|
      Hemorrhage, Multifocal               |                                                                          |      1  4.0|
      Hydrocephalus                        |                                  3                                       |      3  3.0|
      Thalamus, Gliosis, Focal             |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  50                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 6| 7| 7| 5| 6| 6| 7| 5| 5| 5| 5| 7| 7| 7| 7| 6| 4| 7| 6| 7| 6| 7|            |
                             DAY ON TEST   | 0| 1| 7| 4| 2| 2| 3| 2| 5| 3| 5| 9| 5| 2| 3| 2| 2| 2| 9| 9| 2| 4| 3| 9| 3|            |
                                           | 7| 3| 3| 3| 9| 9| 2| 3| 8| 0| 7| 9| 3| 5| 0| 9| 9| 9| 3| 2| 1| 7| 0| 7| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  M  +  +  +  M  +  +  +  M  +  +  M  +  +  +  +     M  +  +  +  +  +|  37        |
      Inflammation, Chronic Active, Focal  |                                           3                       2      |      7  2.4|
      Inflammation, Focal, Suppurative     |                                     1                                    |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Edema, Focal                         |                                                                4         |      1  4.0|
      Hemorrhage, Multifocal, Subacute     |                                                                          |      1  3.0|
      Bronchus, Epithelium, Hyperplasia,   |                                                                          |            |
           Focal                           |                                                                3         |      1  3.0|
      Interstitium, Inflammation, Chronic, |                                                                          |            |
           Focal                           |                                                                          |      1  1.0|
      Interstitium, Inflammation, Chronic, |                                                                          |            |
           Multifocal                      |    4                                                                    4|      2  4.0|
      Vein, Mineralization, Multifocal     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Lumen, Exudate                       |                                                                          |      2  1.5|
      Lumen, Foreign Body                  |          1                                                               |      2  1.5|
      Mucosa, Inflammation, Chronic        |                               1                                          |      4  1.3|
      Mucosa, Inflammation, Chronic Active |                                                                          |      2  2.0|
      Mucosa, Thrombosis, Multifocal       |                               1                    2                     |      5  2.4|
      Nasolacrimal Duct, Exudate           |          2                                                               |      1  2.0|
      Nasolacrimal Duct, Hyperplasia       |                                                                          |      1  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic                         |                   2        2              2  2  2                    1   |     14  1.9|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic Active                  |    2     3                          2  2                          3      |      5  2.4|
      Olfactory Epithelium, Atrophy        |                   1                 1                                    |      2  1.0|
      Olfactory Epithelium, Hyperplasia,   |                                                                          |            |
           Eosinophil                      |                                                                          |      1  2.0|
      Respiratory Epithelium, Cyst         |                   2           1                                          |      2  1.5|
      Respiratory Epithelium, Hyperplasia, |                                                                          |            |
           Eosinophil                      | 2                                                              1         |      4  1.5|
      Respiratory Epithelium, Hyperplasia  |                            1                       1        1            |      8  1.4|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Artery, Inflammation, Chronic Active,|                                                                          |            |
           Focal                           |                            2                                             |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  51                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 6| 7| 7| 5| 6| 6| 7| 5| 5| 5| 5| 7| 7| 7| 7| 6| 4| 7| 6| 7| 6| 7|            |
                             DAY ON TEST   | 0| 1| 7| 4| 2| 2| 3| 2| 5| 3| 5| 9| 5| 2| 3| 2| 2| 2| 9| 9| 2| 4| 3| 9| 3|            |
                                           | 7| 3| 3| 3| 9| 9| 2| 3| 8| 0| 7| 9| 3| 5| 0| 9| 9| 9| 3| 2| 1| 7| 0| 7| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   3        |
      Choroid, Left, Hemorrhage            |                                                                          |      1  4.0|
      Retina, Degeneration                 |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Nephropathy, Chronic                 | 1  3  3  3  4  4  1  3  2  4  2  4  2     4  3  4  3  3     4  2  3  3  3|     46  3.1|
      Pigmentation, Diffuse                |       2              4        2     1                 2        3     1   |      8  2.3|
      Pigmentation, Multifocal             |                                                    3                     |      2  2.5|
      Cortex, Cyst                         |                                                                          |      1  2.0|
      Cortex, Hyperplasia, Atypical        |                                           2                              |      1  2.0|
      Transitional Epithelium, Hyperplasia |                                                 3                        |      2  3.0|
      Transitional Epithelium,             |                                                                          |            |
          Mineralization                   |                                                 1                        |      4  1.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  48        |
      Calculus Gross Observation           |                                                                          |      1     |
      Inflammation, Chronic Active, Focal  |                                                                          |      1  2.0|
      Lumen, Calculus Micro Observation    |                                                                          |            |
          Only, Single                     |                                                                          |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  52                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 6| 6| 7| 5| 7| 7| 7| 5| 7| 5| 5| 6| 7| 6| 5| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 1| 0| 1| 9| 4| 2| 4| 0| 2| 0| 6| 2| 2| 1| 7| 2| 4| 4| 2| 2| 3| 3| 2|             
                                           | 9| 8| 1| 1| 9| 4| 4| 8| 8| 4| 9| 0| 7| 9| 9| 2| 8| 8| 7| 1| 8| 8| 0| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    300 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Mineralization, Multifocal           |                                                                         4|             
      Parasite Metazoan                    |    X                 X                                               X   |             
      Artery, Inflammation, Chronic Active,|                                                                          |             
           Focal                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  M  +  +  +  +  +  +  +  M  +  M  M  +  +  +  M  +  +  +  +  +|             
      Parasite Metazoan                    |                            X                                             |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  A  +  +  M  +  +  +  +  +|             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                                                                      2   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                                                             2            |             
      Angiectasis, Multifocal              |                2                                                     2  2|             
      Basophilic Focus                     |                X                                               X        X|             
      Basophilic Focus, Multiple           |                      X                                                   |             
      Cytoplasmic Alteration, Focal        |                2                                                         |             
      Degeneration, Ballooning, Focal      |                                                    3           2         |             
      Eosinophilic Focus                   |                                                                          |             
      Fatty Change, Diffuse                |                                                                          |             
      Fatty Change, Multifocal             |                1                                      1              2   |             
      Granuloma, Multifocal                |                                           3                              |             
      Hemorrhage, Multifocal               |          2                                                               |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Hyperplasia, Focal, Nodular          |                                                                          |             
      Necrosis, Focal                      |                               1                                          |             
      Necrosis, Multifocal                 |       2           3        1                                2            |             
      Bile Duct, Fibrosis, Multifocal      |       3                                                                  |             
      Bile Duct, Hyperplasia, Multifocal   |    1  3  3  3     4  2     2  2     2  3        2  2        1  2  1  1  3|             
      Centrilobular, Degeneration, Diffuse |                                                                          |             
      Centrilobular, Degeneration,         |                                                                          |             
          Multifocal                       |                   3                                                      |             
      Centrilobular, Fatty Change, Diffuse |       3                                      3                           |             
      Periportal, Cytomegaly, Diffuse      |                                                                          |             
      Periportal, Fatty Change, Diffuse    |                         4                                                |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                  +  +                                   +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 6| 6| 7| 5| 7| 7| 7| 5| 7| 5| 5| 6| 7| 6| 5| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 1| 0| 1| 9| 4| 2| 4| 0| 2| 0| 6| 2| 2| 1| 7| 2| 4| 4| 2| 2| 3| 3| 2|             
                                           | 9| 8| 1| 1| 9| 4| 4| 8| 8| 4| 9| 0| 7| 9| 9| 2| 8| 8| 7| 1| 8| 8| 0| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    300 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Accessory Spleen, Two                |                                  X                                       |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                                                                          |             
      Artery, Inflammation, Chronic, Focal |                                                                          |             
      Artery, Mineralization, Multifocal   |                                                                         4|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy, Focal               |                               1        2                                 |             
      Acinus, Atrophy, Multifocal          |       1  2        3  2  1  3     2              1  2           2         |             
      Acinus, Hyperplasia, Focal           |    3                                                                     |             
      Artery, Inflammation, Chronic Active,|                                                                          |             
           Focal                           |             2                                                            |             
      Artery, Inflammation, Chronic Active,|                                                                          |             
           Multifocal                      |                      4                                                   |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                 +                        |             
      Palate, Inflammation, Chronic, Focal |                                                 2                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |          3     4        3                                                |             
      Mineralization, Diffuse              |                                                                         4|             
      Ulcer                                |                   3                                                      |             
      Epithelium, Hyperplasia              |          2     3        3                                                |             
      Submucosa, Edema, Diffuse            |                                  3                                       |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active, Focal  |                                                                          |             
      Mineralization, Diffuse              |                                                                         4|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                    +                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    2  3  3  2  2     3  2  2  2  2     2  2  1  3  3  3  1  2     3  4  3|             
      Mineralization, Multifocal           |                                                                         4|             
      Atrium Left, Thrombosis              |                                                                          |             
      Myocardium, Fibrosis, Focal          |                                                                3         |             
      Valve, Fibrosis, Focal               |                                                                   3      |             
      Valve, Inflammation, Focal,          |                                                                          |             
          Proliferative                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Accessory Adrenal Cortical  |                                                                          |             
          Nodule                           |                                                          X               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cytoplasmic Alteration, Focal        |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 6| 6| 7| 5| 7| 7| 7| 5| 7| 5| 5| 6| 7| 6| 5| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 1| 0| 1| 9| 4| 2| 4| 0| 2| 0| 6| 2| 2| 1| 7| 2| 4| 4| 2| 2| 3| 3| 2|             
                                           | 9| 8| 1| 1| 9| 4| 4| 8| 8| 4| 9| 0| 7| 9| 9| 2| 8| 8| 7| 1| 8| 8| 0| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    300 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Degeneration, Diffuse, Fatty         |          2        2     3        2                                       |             
      Degeneration, Fatty, Focal           |                2           2                          2  2               |             
      Degeneration, Fatty, Multifocal      |    2  2                                                                  |             
      Hyperplasia, Focal                   |                            1              1                 1     1      |             
      Hyperplasia, Multifocal              |                      1                 2                                 |             
      Hypertrophy, Focal                   |                                                                          |             
      Hypertrophy, Multifocal              |       2                                                                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                  3                                   2   |             
      Hyperplasia, Multifocal              |          2                                                              2|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                             1            |             
      Hyperplasia, Multifocal              |                3                                                         |             
      Inflammation, Multifocal             |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +|             
      Hyperplasia                          |          3                    2                                      2  4|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                   3                                         2            |             
      Pars Distalis, Cyst                  |             X                                                     3      |             
      Pars Distalis, Degeneration, Fatty,  |                                                                          |             
           Focal                           |                                                                   2      |             
      Pars Distalis, Hyperplasia, Focal    | 3              2  3  2                                      2            |             
      Pars Distalis, Hyperplasia           |                                                                         3|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia, Focal           |                                                                          |             
      C-Cell, Hyperplasia, Multifocal      |                                                                         2|             
      Follicle, Cyst                       |                3                                                         |             
      Follicular Cell, Degeneration,       |                                                                          |             
          Multifocal                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                              +                           |             
      Necrosis, Focal                      |                                              4                           |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation, Multifocal               |                                                                          |             
      Granuloma Sperm, Single              |                   3                                                      |             
      Left, Atrophy                        |                               2                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                   4                                      3               |             
      Inflammation, Chronic Active         |    2                                               3              3      |             
      Inflammation, Diffuse, Granulomatous |                                           3                              |             
      Inflammation, Focal, Granulomatous   |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 6| 6| 7| 5| 7| 7| 7| 5| 7| 5| 5| 6| 7| 6| 5| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 1| 0| 1| 9| 4| 2| 4| 0| 2| 0| 6| 2| 2| 1| 7| 2| 4| 4| 2| 2| 3| 3| 2|             
                                           | 9| 8| 1| 1| 9| 4| 4| 8| 8| 4| 9| 0| 7| 9| 9| 2| 8| 8| 7| 1| 8| 8| 0| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    300 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |       2                 3  2  1  3  2                                2   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                  2                             3         |             
      Hyperplasia, Multifocal              |       1              2                                                   |             
      Inflammation, Chronic Active         |       3  2     3           3        2     3  2                          2|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  M  +  +  +  +  +  +     +  +  M  M  +  +  +  M  +  +  +  +  +|             
      Atrophy, Diffuse                     |                                                                3         |             
      Fibrosis, Multifocal                 |                                                                          |             
      Inflammation, Chronic Active,        |                                                                          |             
          Diffuse, Suppurative             |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization, Multifocal           |                                        2                                 |             
      Arteriole, Inflammation              |    3           2        3                       2                        |             
      Capsule, Hyperplasia, Multifocal     |                                                                          |             
      Interstitial Cell, Hyperplasia       |                2                                                         |             
      Seminiferous Tubule, Atrophy         |                   2  4     2                                   3         |             
      Seminiferous Tubule, Degeneration    |       3                 2                    2        3                  |             
      Serosa, Necrosis, Focal              |                         4                                                |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                        2                             3   |             
      Myeloid Cell, Hyperplasia            |          2                                               3               |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumbar, Hemorrhage                   |                                                                          |             
      Mediastinal, Hemorrhage              |                         3                       3                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                       3                  |             
      Hyperplasia, Lymphoid                |                                                          2               |             
      Hyperplasia, Plasma Cell             |                         2                 3                          2   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                                                         3|             
      Fibrosis, Multifocal                 |       2                                                                  |             
      Hemorrhage                           |                         2  2                                             |             
      Hyperplasia, Lymphoid                |                                                          2               |             
      Hyperplasia, Re Cell                 |          2                                                               |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Depletion Lymphoid                   |                                                                          |             
      Fibrosis, Focal                      |       3                                                        2         |             
      Pigmentation, Hemosiderin            |                         2                 3           2                  |             
      Thrombosis, Single                   |                            3                                             |             
      Capsule, Fibrosis, Focal             |                                        4                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 6| 6| 7| 5| 7| 7| 7| 5| 7| 5| 5| 6| 7| 6| 5| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 1| 0| 1| 9| 4| 2| 4| 0| 2| 0| 6| 2| 2| 1| 7| 2| 4| 4| 2| 2| 3| 3| 2|             
                                           | 9| 8| 1| 1| 9| 4| 4| 8| 8| 4| 9| 0| 7| 9| 9| 2| 8| 8| 7| 1| 8| 8| 0| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    300 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Capsule, Fibrosis, Multifocal        |                                  3                                       |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  M  +  +  +  M  +  M  +  +  +  M  +  +  +  +  M  +|             
      Depletion Lymphoid                   |                                                                         4|             
      Hyperplasia, Tubular                 |                2                                               3         |             
      Artery, Inflammation, Chronic Active |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia, Diffuse                     |                         4                                                |             
      Ectasia, Multifocal                  |    4  2                    4              3           4                  |             
      Granuloma                            |                                                                      2   |             
      Hyperplasia, Diffuse                 |                                                    2        2        3  2|             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic, Focal         |                                                                      3   |             
      Ulcer                                |                                                                          |             
      Subcutaneous Tissue, Cyst            |             X                                                            |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                2                                                        3|             
      Osteopetrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                     +                                    |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                         X  X              X     X     X              X   |             
      Hemorrhage, Focal                    |                                                                          |             
      Hemorrhage, Multifocal               |                                                                          |             
      Hydrocephalus                        |                         2  2                    1     2                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  M  +  +  +  +  +  +  +  M  +  M  M  +  +  +  M  +  +  +  +  +|             
      Inflammation, Chronic, Multifocal    |                            2                                             |             
      Inflammation, Chronic Active, Focal  |          2                    2                                      1   |             
      Submucosa, Dilatation                |                                                                         3|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Multifocal, Subacute     |                                                                          |             
      Mineralization, Multifocal           |                                                                         4|             
      Artery, Mineralization, Focal        |                                              2                           |             
      Bronchus, Hyperplasia, Focal,        |                                                                          |             
          Lymphoid                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 6| 6| 7| 5| 7| 7| 7| 5| 7| 5| 5| 6| 7| 6| 5| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 1| 0| 1| 9| 4| 2| 4| 0| 2| 0| 6| 2| 2| 1| 7| 2| 4| 4| 2| 2| 3| 3| 2|             
                                           | 9| 8| 1| 1| 9| 4| 4| 8| 8| 4| 9| 0| 7| 9| 9| 2| 8| 8| 7| 1| 8| 8| 0| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    300 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Interstitium, Inflammation, Acute,   |                                                                          |             
           Multifocal                      |                                                                          |             
      Interstitium, Inflammation, Chronic, |                                                                          |             
           Multifocal                      |                                                                         3|             
      Interstitium, Inflammation, Chronic  |                                                                          |             
          Active, Multifocal               |                                        3                             3   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Exudate                       |                               3                                          |             
      Lumen, Foreign Body                  |                            2                          1                  |             
      Mucosa, Inflammation, Chronic        |                               2     1                                    |             
      Mucosa, Inflammation, Chronic Active |    2     1     1                                      2                  |             
      Mucosa, Thrombosis, Multifocal       |                                     4        2                           |             
      Nasolacrimal Duct, Exudate           |                                                                          |             
      Nasolacrimal Duct, Fungus            |                                                       4                  |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |                            2                 1        4     1     1     1|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic Active                  |                      2                                                   |             
      Olfactory Epithelium, Atrophy        |          2                                                              1|             
      Olfactory Epithelium, Cyst           |                                  1                                1      |             
      Olfactory Epithelium, Erosion        |                                                                          |             
      Olfactory Epithelium, Inflammation,  |                                                                          |             
           Chronic Active                  |                                                                          |             
      Olfactory Epithelium, Metaplasia     |                                                 1     1                  |             
      Respiratory Epithelium, Cyst         | 1  2  2  1                                                               |             
      Respiratory Epithelium, Hyperplasia, |                                                                          |             
           Eosinophil                      |                                                                          |             
      Respiratory Epithelium, Hyperplasia  |    3  1  2     3  1     1  2  2  2  1  2        2  1  1  1  1     2  2  2|             
      Respiratory Epithelium, Hyperplasia, |                                                                          |             
           Papillary                       |                               2                       1                  |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                     2                                    |             
      Glands, Metaplasia, Focal, Squamous  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |          +                 +     +                                       |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Focal, Suppurative     |                                                                          |             
      Mineralization, Diffuse              |                                                                         4|             
      Nephropathy, Chronic                 | 4  4  4  4     4  3  4  4  4  4  4  1  4  4  2  4  4  4  3  4  4  4  4  4|             
      Pigmentation, Diffuse                |                                                                          |             
      Pigmentation, Multifocal             |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 6| 6| 7| 5| 7| 7| 7| 5| 7| 5| 5| 6| 7| 6| 5| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 1| 0| 1| 9| 4| 2| 4| 0| 2| 0| 6| 2| 2| 1| 7| 2| 4| 4| 2| 2| 3| 3| 2|             
                                           | 9| 8| 1| 1| 9| 4| 4| 8| 8| 4| 9| 0| 7| 9| 9| 2| 8| 8| 7| 1| 8| 8| 0| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    300 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Artery, Inflammation, Chronic Active,|                                                                          |             
           Focal                           |                                                                          |             
      Cortex, Cyst                         |                                                                      X   |             
      Cortex, Hyperplasia, Atypical        |       2        2                                                         |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Necrosis, Acute, Multifocal     |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Ectasia                              |                                                                          |             
      Inflammation, Diffuse, Subacute      |                                                                          |             
      Subserosa, Mineralization, Focal     |                                              2                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  59                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 6| 6| 7| 6| 6| 6| 7| 7| 5| 7| 7| 7| 7| 6| 5| 7| 5| 5| 6| 7| 6| 6| 7|            |
                             DAY ON TEST   | 7| 4| 1| 5| 3| 6| 4| 6| 2| 3| 8| 3| 2| 3| 3| 6| 4| 3| 7| 0| 1| 3| 3| 6| 3|            |
                                           | 9| 8| 7| 3| 0| 6| 8| 0| 9| 0| 9| 0| 4| 0| 0| 9| 1| 0| 5| 6| 1| 1| 8| 7| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    300 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  47        |
      Hyperplasia, Lymphoid                |                                                    2                     |      1  2.0|
      Parasite Metazoan                    |       X              X                       X                          X|      4     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Lymphoid                |                                                    2                     |      1  2.0|
      Mineralization, Multifocal           |                                                                          |      1  4.0|
      Parasite Metazoan                    |                      X  X                                               X|      6     |
      Artery, Inflammation, Chronic Active,|                                                                          |            |
           Focal                           |       1                                                                  |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | A  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  M  M  +  +  +  +  +|  40        |
      Parasite Metazoan                    |                            X                                             |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  44        |
      Inflammation, Chronic Active,        |                                                                          |            |
          Multifocal                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis, Focal                   |                3                                                         |      2  2.5|
      Angiectasis, Multifocal              |                                                                          |      3  2.0|
      Basophilic Focus                     |                                                                          |      3     |
      Basophilic Focus, Multiple           |                                                                          |      1     |
      Cytoplasmic Alteration, Focal        |                                                                          |      1  2.0|
      Degeneration, Ballooning, Focal      |                         2                                                |      3  2.3|
      Eosinophilic Focus                   |                                              X                           |      1     |
      Fatty Change, Diffuse                |          4                                                               |      1  4.0|
      Fatty Change, Multifocal             |             1        1        2                       1              1   |      8  1.3|
      Granuloma, Multifocal                |             2           2     3                                          |      4  2.5|
      Hemorrhage, Multifocal               |                                                                          |      1  2.0|
      Hepatodiaphragmatic Nodule           |                                        X     X                 X         |      3     |
      Hyperplasia, Focal, Nodular          |                                                                   3      |      1  3.0|
      Necrosis, Focal                      |                                                                          |      1  1.0|
      Necrosis, Multifocal                 |    2  3           2                                                  3   |      8  2.3|
      Bile Duct, Fibrosis, Multifocal      |                                                                          |      1  3.0|
      Bile Duct, Hyperplasia, Multifocal   |    2  3                 2  2           2  3  1  3  2        4  1  3     3|     30  2.3|
      Centrilobular, Degeneration, Diffuse |                                                 2                        |      1  2.0|
      Centrilobular, Degeneration,         |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  60                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 6| 6| 7| 6| 6| 6| 7| 7| 5| 7| 7| 7| 7| 6| 5| 7| 5| 5| 6| 7| 6| 6| 7|            |
                             DAY ON TEST   | 7| 4| 1| 5| 3| 6| 4| 6| 2| 3| 8| 3| 2| 3| 3| 6| 4| 3| 7| 0| 1| 3| 3| 6| 3|            |
                                           | 9| 8| 7| 3| 0| 6| 8| 0| 9| 0| 9| 0| 4| 0| 0| 9| 1| 0| 5| 6| 1| 1| 8| 7| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    300 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
          Multifocal                       |                   2                                         2     3      |      4  2.5|
      Centrilobular, Fatty Change, Diffuse |    4  3                                                                  |      4  3.3|
      Periportal, Cytomegaly, Diffuse      |                      1                                                   |      1  1.0|
      Periportal, Fatty Change, Diffuse    |                4                                                         |      2  4.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +     +                                               +                  |   6        |
      Accessory Spleen, Two                |                                                                          |      1     |
      Inflammation, Chronic Active,        |                                                                          |            |
          Multifocal                       | 2                                                                        |      1  2.0|
      Artery, Inflammation, Chronic, Focal |       2                                                                  |      1  2.0|
      Artery, Mineralization, Multifocal   |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acinus, Atrophy, Focal               |                                                                          |      2  1.5|
      Acinus, Atrophy, Multifocal          |    2              1  2              2  4     2     3        1  2  2      |     20  2.0|
      Acinus, Hyperplasia, Focal           |                                                                          |      1  3.0|
      Artery, Inflammation, Chronic Active,|                                                                          |            |
           Focal                           |                                  3                                       |      2  2.5|
      Artery, Inflammation, Chronic Active,|                                                                          |            |
           Multifocal                      |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
      Palate, Inflammation, Chronic, Focal |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic Active         |          3                                            3                  |      5  3.2|
      Mineralization, Diffuse              |                                                                          |      1  4.0|
      Ulcer                                |                4                                                     4   |      3  3.7|
      Epithelium, Hyperplasia              |          3     2                                      2                  |      6  2.5|
      Submucosa, Edema, Diffuse            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active, Focal  |                                                                   3      |      1  3.0|
      Mineralization, Diffuse              |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 4     2  2  1  2     2  3  2  1  3  3     2  2     2  2  3  1     2  3   |     40  2.3|
      Mineralization, Multifocal           |                                                                          |      1  4.0|
      Atrium Left, Thrombosis              |       3                                                           4      |      2  3.5|
      Myocardium, Fibrosis, Focal          |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  61                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 6| 6| 7| 6| 6| 6| 7| 7| 5| 7| 7| 7| 7| 6| 5| 7| 5| 5| 6| 7| 6| 6| 7|            |
                             DAY ON TEST   | 7| 4| 1| 5| 3| 6| 4| 6| 2| 3| 8| 3| 2| 3| 3| 6| 4| 3| 7| 0| 1| 3| 3| 6| 3|            |
                                           | 9| 8| 7| 3| 0| 6| 8| 0| 9| 0| 9| 0| 4| 0| 0| 9| 1| 0| 5| 6| 1| 1| 8| 7| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    300 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Valve, Fibrosis, Focal               |                                                                          |      1  3.0|
      Valve, Inflammation, Focal,          |                                                                          |            |
          Proliferative                    |       3                                                                  |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Capsule, Accessory Adrenal Cortical  |                                                                          |            |
          Nodule                           |                         X                 X                       X      |      4     |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cytoplasmic Alteration, Focal        |                                                                          |      1  2.0|
      Degeneration, Diffuse, Fatty         | 2  2  2        2  1                                                      |      9  2.0|
      Degeneration, Fatty, Focal           |          2                    2                                          |      6  2.0|
      Degeneration, Fatty, Multifocal      |                            2                                             |      3  2.0|
      Hyperplasia, Focal                   |          1                 2  1  2        2                    2         |     10  1.4|
      Hyperplasia, Multifocal              |                                                                          |      2  1.5|
      Hypertrophy, Focal                   |    1                                                                     |      1  1.0|
      Hypertrophy, Multifocal              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  46        |
      Hyperplasia, Focal                   |                            1     2                                1      |      5  1.8|
      Hyperplasia, Multifocal              |                   2                          1                           |      4  1.8|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Focal                   |                                                          3               |      2  2.0|
      Hyperplasia, Multifocal              |    2                    2                 4  4                           |      5  3.0|
      Inflammation, Multifocal             |                                                    3                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Hyperplasia                          |             1                                                            |      5  2.4|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Angiectasis           |                                                 3                        |      3  2.7|
      Pars Distalis, Cyst                  |    4              2                                   3                  |      5  3.0|
      Pars Distalis, Degeneration, Fatty,  |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
      Pars Distalis, Hyperplasia, Focal    |             3                 3                                          |      7  2.6|
      Pars Distalis, Hyperplasia           |                                                             3            |      2  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia, Focal           |                                        2                    1            |      2  1.5|
      C-Cell, Hyperplasia, Multifocal      |             3           1                                                |      3  2.0|
      Follicle, Cyst                       |             3                                                            |      2  3.0|
      Follicular Cell, Degeneration,       |                                                                          |            |
          Multifocal                       |                         2                                                |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  62                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 6| 6| 7| 6| 6| 6| 7| 7| 5| 7| 7| 7| 7| 6| 5| 7| 5| 5| 6| 7| 6| 6| 7|            |
                             DAY ON TEST   | 7| 4| 1| 5| 3| 6| 4| 6| 2| 3| 8| 3| 2| 3| 3| 6| 4| 3| 7| 0| 1| 3| 3| 6| 3|            |
                                           | 9| 8| 7| 3| 0| 6| 8| 0| 9| 0| 9| 0| 4| 0| 0| 9| 1| 0| 5| 6| 1| 1| 8| 7| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    300 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
      Necrosis, Focal                      |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation, Multifocal               |                      3                                                   |      1  3.0|
      Granuloma Sperm, Single              |                                                                          |      1  3.0|
      Left, Atrophy                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  48        |
      Ectasia                              |                                  3                                       |      3  3.3|
      Inflammation, Chronic Active         |                                                                2         |      4  2.5|
      Inflammation, Diffuse, Granulomatous |                                                                          |      1  3.0|
      Inflammation, Focal, Granulomatous   |                               2                                         2|      3  2.0|
      Inflammation, Granulomatous,         |                                                                          |            |
          Multifocal                       |    2  3  2  1  2     3     2     2  2  1  1     3  2     2  2            |     22  2.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Focal                   |                            2        2  3                                 |      5  2.4|
      Hyperplasia, Multifocal              |                   2  2  3                    1                           |      6  1.8|
      Inflammation, Chronic Active         |                4              3        1  1        2                     |     13  2.4|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +|  43        |
      Atrophy, Diffuse                     |             2                          3  3        2                     |      5  2.6|
      Fibrosis, Multifocal                 |                         2                                                |      1  2.0|
      Inflammation, Chronic Active,        |                                                                          |            |
          Diffuse, Suppurative             |                4                                                         |      1  4.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization, Multifocal           |                                                                          |      1  2.0|
      Arteriole, Inflammation              |                                                                          |      4  2.5|
      Capsule, Hyperplasia, Multifocal     |                                                                   2      |      1  2.0|
      Interstitial Cell, Hyperplasia       |                      2                                                   |      2  2.0|
      Seminiferous Tubule, Atrophy         |          2  3  3              3  2        4        3  3        3         |     13  2.8|
      Seminiferous Tubule, Degeneration    |                                                                          |      4  2.5|
      Serosa, Necrosis, Focal              |                                                                   3      |      2  3.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                       3     3           2|      5  2.6|
      Myeloid Cell, Hyperplasia            |                                              4           3               |      4  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  63                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 6| 6| 7| 6| 6| 6| 7| 7| 5| 7| 7| 7| 7| 6| 5| 7| 5| 5| 6| 7| 6| 6| 7|            |
                             DAY ON TEST   | 7| 4| 1| 5| 3| 6| 4| 6| 2| 3| 8| 3| 2| 3| 3| 6| 4| 3| 7| 0| 1| 3| 3| 6| 3|            |
                                           | 9| 8| 7| 3| 0| 6| 8| 0| 9| 0| 9| 0| 4| 0| 0| 9| 1| 0| 5| 6| 1| 1| 8| 7| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    300 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lumbar, Hemorrhage                   |                                              3                           |      1  3.0|
      Mediastinal, Hemorrhage              |             3     2                             2                        |      5  2.6|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                                                    4     2               |      3  2.7|
      Hyperplasia, Plasma Cell             |                                                          2           3   |      5  2.4|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Depletion Lymphoid                   |                                                                          |      1  3.0|
      Fibrosis, Multifocal                 |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      2  2.0|
      Hyperplasia, Lymphoid                |                                                          3               |      2  2.5|
      Hyperplasia, Re Cell                 |                                                    2                 3   |      3  2.3|
                                            __________________________________________________________________________|____________|
   Spleen                                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Congestion                           |                                                                         3|      1  3.0|
      Depletion Lymphoid                   |                                                                         3|      1  3.0|
      Fibrosis, Focal                      |                                                             2  3         |      4  2.5|
      Pigmentation, Hemosiderin            |          3                    3                                2     2   |      7  2.4|
      Thrombosis, Single                   |                                                                          |      1  3.0|
      Capsule, Fibrosis, Focal             |                                                                          |      1  4.0|
      Capsule, Fibrosis, Multifocal        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | A  M  +  +  M  +  +  +  +  +  +  +  +  +  M  +  M  +  +  M  +  +  +  M  +|  38        |
      Depletion Lymphoid                   |                                                                          |      1  4.0|
      Hyperplasia, Tubular                 |                   2     3        3                          2            |      6  2.5|
      Artery, Inflammation, Chronic Active |                                                    3                     |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  46        |
      Ectasia, Diffuse                     |          3           4                                               4   |      4  3.8|
      Ectasia, Multifocal                  |                3                                                         |      6  3.3|
      Granuloma                            |                                                                          |      1  2.0|
      Hyperplasia, Diffuse                 |                                     2     2        1                     |      7  2.0|
      Hyperplasia, Focal                   |             4                                                            |      1  4.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic, Focal         |                                                                          |      1  3.0|
      Ulcer                                |                                                    4                     |      1  4.0|
      Subcutaneous Tissue, Cyst            |                                                                          |      1     |
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic Active                  |                                                    4                     |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  64                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 6| 6| 7| 6| 6| 6| 7| 7| 5| 7| 7| 7| 7| 6| 5| 7| 5| 5| 6| 7| 6| 6| 7|            |
                             DAY ON TEST   | 7| 4| 1| 5| 3| 6| 4| 6| 2| 3| 8| 3| 2| 3| 3| 6| 4| 3| 7| 0| 1| 3| 3| 6| 3|            |
                                           | 9| 8| 7| 3| 0| 6| 8| 0| 9| 0| 9| 0| 4| 0| 0| 9| 1| 0| 5| 6| 1| 1| 8| 7| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    300 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                                                                          |      2  2.5|
      Osteopetrosis                        |                                                                         2|      1  2.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                      X                             3                 X   |      9  3.0|
      Hemorrhage, Focal                    |                                     3                                    |      1  3.0|
      Hemorrhage, Multifocal               |                   4                                         2            |      2  3.0|
      Hydrocephalus                        |          2           2              2                                2   |      8  1.9|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +     M  +  +  +  +  +|  41        |
      Inflammation, Chronic, Multifocal    |                                              1                           |      2  1.5|
      Inflammation, Chronic Active, Focal  |                            2                                            2|      5  1.8|
      Submucosa, Dilatation                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage, Multifocal, Subacute     |                   2                                                      |      1  2.0|
      Mineralization, Multifocal           |                                                                          |      1  4.0|
      Artery, Mineralization, Focal        |                                                                          |      1  2.0|
      Bronchus, Hyperplasia, Focal,        |                                                                          |            |
          Lymphoid                         |                                                    2                     |      1  2.0|
      Interstitium, Inflammation, Acute,   |                                                                          |            |
           Multifocal                      |                                                                         2|      1  2.0|
      Interstitium, Inflammation, Chronic, |                                                                          |            |
           Multifocal                      | 1                                                                        |      2  2.0|
      Interstitium, Inflammation, Chronic  |                                                                          |            |
          Active, Multifocal               |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lumen, Exudate                       |                2                                                         |      2  2.5|
      Lumen, Foreign Body                  |                1  1                                                      |      4  1.3|
      Mucosa, Inflammation, Chronic        |                2              1                       2                 1|      6  1.5|
      Mucosa, Inflammation, Chronic Active |                                                                          |      4  1.5|
      Mucosa, Thrombosis, Multifocal       |       3                                                                  |      3  3.0|
      Nasolacrimal Duct, Exudate           | 3                                   1                             2      |      3  2.0|
      Nasolacrimal Duct, Fungus            |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  65                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 6| 6| 7| 6| 6| 6| 7| 7| 5| 7| 7| 7| 7| 6| 5| 7| 5| 5| 6| 7| 6| 6| 7|            |
                             DAY ON TEST   | 7| 4| 1| 5| 3| 6| 4| 6| 2| 3| 8| 3| 2| 3| 3| 6| 4| 3| 7| 0| 1| 3| 3| 6| 3|            |
                                           | 9| 8| 7| 3| 0| 6| 8| 0| 9| 0| 9| 0| 4| 0| 0| 9| 1| 0| 5| 6| 1| 1| 8| 7| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    300 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic                         |                               2     1     3  1                           |     10  1.7|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic Active                  | 3           1                                         2           3      |      5  2.2|
      Olfactory Epithelium, Atrophy        |                                                                      2   |      3  1.7|
      Olfactory Epithelium, Cyst           |                            1     1        1  1                           |      6  1.0|
      Olfactory Epithelium, Erosion        |          2                                                               |      1  2.0|
      Olfactory Epithelium, Inflammation,  |                                                                          |            |
           Chronic Active                  |          1                                                               |      1  1.0|
      Olfactory Epithelium, Metaplasia     |          2                          2                                    |      4  1.5|
      Respiratory Epithelium, Cyst         |       1  2                 1              1                             1|      9  1.3|
      Respiratory Epithelium, Hyperplasia, |                                                                          |            |
           Eosinophil                      |                                           1                              |      1  1.0|
      Respiratory Epithelium, Hyperplasia  |                2  2                 1  1     2  2              1  1      |     27  1.6|
      Respiratory Epithelium, Hyperplasia, |                                                                          |            |
           Papillary                       |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                                          1               |      2  1.5|
      Glands, Metaplasia, Focal, Squamous  |                                           2                              |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                   +                                +                     |   5        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Focal, Suppurative     |                1                                                         |      1  1.0|
      Mineralization, Diffuse              |                                                                          |      1  4.0|
      Nephropathy, Chronic                 | 2  1  3  1  4  4  3  4  4  4  2  4  4  4  4  4  2  4     1  3  4  3  4  4|     48  3.5|
      Pigmentation, Diffuse                |    1  2                                         3           1     3      |      5  2.0|
      Pigmentation, Multifocal             |                                                                          |      1  2.0|
      Artery, Inflammation, Chronic Active,|                                                                          |            |
           Focal                           |                                                    3                     |      1  3.0|
      Cortex, Cyst                         |          X                                                              3|      3  3.0|
      Cortex, Hyperplasia, Atypical        |                                                                          |      2  2.0|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Necrosis, Acute, Multifocal     |    3                                                                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Ectasia                              |                                                             4            |      1  4.0|
      Inflammation, Diffuse, Subacute      |                                                                      3   |      1  3.0|
      Subserosa, Mineralization, Focal     |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  66                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 6| 7| 6| 5| 4| 6| 5| 7| 6| 7| 6| 6| 5| 7| 7| 6| 5| 7| 5| 7| 6|             
                             DAY ON TEST   | 2| 2| 3| 3| 9| 2| 9| 5| 8| 6| 3| 2| 8| 2| 2| 9| 3| 2| 2| 8| 5| 2| 8| 1| 8|             
                                           | 9| 9| 3| 3| 5| 8| 7| 4| 4| 0| 9| 9| 9| 8| 4| 7| 9| 8| 8| 0| 4| 8| 3| 4| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    100 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |          +           +  +     +        +        +     +     +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large                         |          +           +  +     +        +        +     +     +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |          M           +  M     +        +        A     +     +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |          +           +  +     +        +        A     +     +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |          +           +  +     M        +        A     +     +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small                         |          +           +  +     +        +        +     +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |          +           +  +     +        +        A     +     +  +  +     +|             
      Inflammation, Acute, Multifocal      |                                                                         2|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |          +           +  +     +        +        A     +     +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |          +           +  +     +        +        A     +     +  +  +      |             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  +  +  +     +  +  +  +     +  +  +  +  +     +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                            2                          2                  |             
      Basophilic Focus                     |                            X           X                          X      |             
      Basophilic Focus, Multiple           |                                                       X                  |             
      Congestion                           |                                     4           3                        |             
      Cytomegaly, Focal                    |                                                                          |             
      Cytomegaly, Multifocal               |                                                                          |             
      Eosinophilic Focus                   |                                                                X         |             
      Fatty Change, Diffuse                |                                                             4        3  2|             
      Fatty Change, Focal                  |                               3                                          |             
      Fatty Change, Multifocal             |                                                       1  2               |             
      Hepatodiaphragmatic Nodule           |                         X                                                |             
      Hepatodiaphragmatic Nodule, Multiple |                                                                          |             
      Mitotic Alteration                   |                                     1                                    |             
      Necrosis, Focal                      |                                                                          |             
      Necrosis, Multifocal                 |                                                                   2      |             
      Pigmentation, Multifocal             |                         2                                                |             
      Vacuolization Cytoplasmic, Multifocal|                                                                          |             
      Bile Duct, Hyperplasia, Multifocal   |    2     3              2              2  2  3        1  3     1  2      |             
      Centrilobular, Degeneration, Diffuse |       3                                      2                           |             
      Centrilobular, Fatty Change, Diffuse |                         3                                                |             
      Centrilobular, Necrosis, Multifocal  |                                                                          |             
      Periportal, Fatty Change, Diffuse    |             2                                                            |             
      Portal, Fibrosis, Multifocal         |                                        2                                 |             
      Portal, Inflammation, Chronic Active,|                                                                          |             
           Multifocal                      |                      1                                                   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                     +                                    |             
      Artery, Ectasia, Multifocal          |                                                                          |             
      Artery, Inflammation, Chronic,       |                                                                          |             
          Multifocal                       |                                                                          |             
      Artery, Mineralization, Multifocal   |                                                                          |             
      Fat, Necrosis, Focal                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |          +           +  M     +              +  +     +     +  +  +      |             
      Acinus, Atrophy, Diffuse             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 6| 7| 6| 5| 4| 6| 5| 7| 6| 7| 6| 6| 5| 7| 7| 6| 5| 7| 5| 7| 6|             
                             DAY ON TEST   | 2| 2| 3| 3| 9| 2| 9| 5| 8| 6| 3| 2| 8| 2| 2| 9| 3| 2| 2| 8| 5| 2| 8| 1| 8|             
                                           | 9| 9| 3| 3| 5| 8| 7| 4| 4| 0| 9| 9| 9| 8| 4| 7| 9| 8| 8| 0| 4| 8| 3| 4| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    100 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Acinus, Atrophy, Multifocal          |                                              2                           |             
      Artery, Ectasia, Multifocal          |                                                                          |             
      Artery, Fibrosis                     |                                                                          |             
      Artery, Inflammation, Chronic,       |                                                                          |             
          Multifocal                       |                                                                          |             
      Artery, Mineralization, Multifocal   |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       +  +           +  +     +  +     +        +     +     +     +      |             
                                            __________________________________________________________________________|             
   Stomach                                 |          +           +  +     +        +        +     +     +  +  +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |          +           +  +     +        +        +     +     +  +  +      |             
      Inflammation, Chronic Active         |                               3                             4            |             
      Ulcer                                |                                                             4            |             
      Epithelium, Hyperplasia              |                               2                             2            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |          +           +  +     +        +        +     +     +  +  +      |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                +                       +                                 |             
      Dysplasia                            |                3                       1                                 |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |          +           +  +     +        +        +     +     +  +  +      |             
      Cardiomyopathy                       |          1                             3        4     2     2  3  2      |             
      Atrium Left, Thrombosis              |                         1                                                |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |          +     +     +  +     +        +        +     +  +  +  +  +     +|             
      Capsule, Accessory Adrenal Cortical  |                                                                          |             
          Nodule                           |                               X                       X                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |          +           +  +     +        +        +     +  +  +  +  +     +|             
      Degeneration, Diffuse, Fatty         |                         3                                   2     2      |             
      Degeneration, Fatty, Focal           |                                        2              2     3            |             
      Degeneration, Fatty, Multifocal      |                                                                          |             
      Hyperplasia, Focal                   |                               3                                          |             
      Hypertrophy, Focal                   |                                                       2                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |          +     +     +  +     +        +        +        +  +  +  +     M|             
      Hyperplasia, Focal                   |                                        2                          3      |             
      Hyperplasia, Multifocal              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |          +           +  M     +              +  +     +     +  +  +      |             
      Hyperplasia, Multifocal              |                      2                                1                  |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |          +           +  +     +        +        +     +     M  +  +      |             
      Hyperplasia                          |                                        3                                 |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +     +  +  +  +  +  +     +  +  +  +        +     +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                         2                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  68                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 6| 7| 6| 5| 4| 6| 5| 7| 6| 7| 6| 6| 5| 7| 7| 6| 5| 7| 5| 7| 6|             
                             DAY ON TEST   | 2| 2| 3| 3| 9| 2| 9| 5| 8| 6| 3| 2| 8| 2| 2| 9| 3| 2| 2| 8| 5| 2| 8| 1| 8|             
                                           | 9| 9| 3| 3| 5| 8| 7| 4| 4| 0| 9| 9| 9| 8| 4| 7| 9| 8| 8| 0| 4| 8| 3| 4| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    100 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Cyst                  |                   2              3                                       |             
      Pars Distalis, Hyperplasia, Focal    |                         3                                                |             
      Pars Distalis, Hyperplasia           |                                                                3         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |          +        +  +  +     +        +        +     +     M  +  +      |             
      C-Cell, Hyperplasia, Focal           |                                                                   2      |             
      C-Cell, Hyperplasia, Multifocal      |                                                       3                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |          +           +  +     +        +        +     +     +  +  M      |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |          +           +  +     +        +        +     +     +  +  +     +|             
      Abscess                              |                                                                4         |             
      Ectasia                              |          3                                                              4|             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |                      2                 1              2                  |             
                                            __________________________________________________________________________|             
   Prostate                                |          +     +     +  +     +        +  +     +           +  +  +      |             
      Hyperplasia, Multifocal              |                3                       4                                 |             
      Inflammation, Chronic Active         |                      1  2                                   3     2      |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +     M           +  M     M        +  +     M     +     +  +  +      |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  M  +  +|             
      Hemorrhage                           |                                                                          |             
      Mineralization, Multifocal           |                                                                          |             
      Arteriole, Inflammation              |                                                       3                  |             
      Interstitial Cell, Hyperplasia       |                3                                                        2|             
      Seminiferous Tubule, Atrophy         | 3              4                       3     2                          3|             
      Serosa, Necrosis, Focal              |                                                                      3   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |          +           +  +     +        +        +     +     +  +  +      |             
      Atrophy                              |                                                       3                  |             
      Hyperplasia                          |                                                                2         |             
      Metaplasia, Osseous                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +  +        +  +  +  +  +     +  +     +  +     +     +  +  +      |             
      Mediastinal, Hemorrhage              |                                        2                                 |             
      Pancreatic, Hemorrhage               |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |       +  +           +  M  +  +        +        +     +     +     +      |             
      Hemorrhage                           |       3                                                                  |             
      Hyperplasia, Plasma Cell             |                            3                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |       M  +        +  +  +     +                 +     +     +  +  +      |             
      Hemorrhage                           |                   3                                               2      |             
                                            __________________________________________________________________________|             
   Spleen                                  |       +  +           +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Congestion                           |                                                 4                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  69                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 6| 7| 6| 5| 4| 6| 5| 7| 6| 7| 6| 6| 5| 7| 7| 6| 5| 7| 5| 7| 6|             
                             DAY ON TEST   | 2| 2| 3| 3| 9| 2| 9| 5| 8| 6| 3| 2| 8| 2| 2| 9| 3| 2| 2| 8| 5| 2| 8| 1| 8|             
                                           | 9| 9| 3| 3| 5| 8| 7| 4| 4| 0| 9| 9| 9| 8| 4| 7| 9| 8| 8| 0| 4| 8| 3| 4| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    100 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Fibrosis, Focal                      |                                                          2               |             
      Fibrosis, Multifocal                 |                                  3                                       |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Pigmentation, Hemosiderin            |                                                             2            |             
                                            __________________________________________________________________________|             
   Thymus                                  |       +  +        +  +  +     M        +        M     +     +  +  +      |             
      Angiectasis, Multifocal              |                                                                          |             
      Hemorrhage                           |       3                                                                  |             
      Hyperplasia, Tubular                 |                                        2                       2         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +     +  +        +  M     +        +        +     +     +  +  +  +   |             
      Ectasia, Diffuse                     | 4                             2                                      3   |             
      Ectasia, Multifocal                  |             4        3                 1              2     3     2      |             
      Hyperplasia, Diffuse                 |    2                                                                     |             
      Inflammation, Granulomatous          | 3                                                                        |             
                                            __________________________________________________________________________|             
   Skin                                    |    +     +  +  +     +  +  +  +        +     +  +     +     +  +  +      |             
      Cyst Epithelial Inclusion            |    X                       4                                             |             
      Hyperkeratosis                       |                4                                               3         |             
      Hyperplasia, Squamous                |                2                                                         |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |    4           4                                                         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |          +        +  +  +     +        +        +     +     +  +  +      |             
      Fibrous Osteodystrophy               |                   3                                                      |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Hemorrhage, Acute                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |          +           +  +     +        +        +     +     +  +  +      |             
      Compression                          |                      X        X                 X     X     X            |             
      Hydrocephalus                        |                               2                       3                  |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Multifocal, Mixed Cell          |                               3                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  |          M           M  M     M        +        M     +     +  +  M      |             
      Inflammation, Chronic Active, Focal  |                                                                2         |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Multifocal                      |                                                             3        3   |             
      Interstitium, Inflammation, Chronic, |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  70                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 6| 7| 6| 5| 4| 6| 5| 7| 6| 7| 6| 6| 5| 7| 7| 6| 5| 7| 5| 7| 6|             
                             DAY ON TEST   | 2| 2| 3| 3| 9| 2| 9| 5| 8| 6| 3| 2| 8| 2| 2| 9| 3| 2| 2| 8| 5| 2| 8| 1| 8|             
                                           | 9| 9| 3| 3| 5| 8| 7| 4| 4| 0| 9| 9| 9| 8| 4| 7| 9| 8| 8| 0| 4| 8| 3| 4| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    100 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Diffuse                         |                                                                          |             
      Interstitium, Inflammation, Chronic, |                                                                          |             
           Multifocal                      |             2     3                                               1      |             
      Interstitium, Mineralization,        |                                                                          |             
          Multifocal                       |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Exudate                       |             1                                                            |             
      Lumen, Foreign Body                  |                   3                                   1                  |             
      Mucosa, Inflammation, Chronic        | 2                    3           1                                       |             
      Mucosa, Inflammation, Chronic Active |                   3                                            1     2   |             
      Mucosa, Thrombosis, Multifocal       |       2                 3                                                |             
      Nasolacrimal Duct, Exudate           |       4                                                                  |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |       2                                                                  |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |          2  1        2     2        1                    1        2      |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic Active                  |                                                                          |             
      Olfactory Epithelium, Atrophy        |                                                                          |             
      Olfactory Epithelium, Cyst           |                1                                                         |             
      Olfactory Epithelium, Erosion        |                                                    3     1  1        2  1|             
      Olfactory Epithelium, Metaplasia     |                2  1                                                  1   |             
      Respiratory Epithelium, Cyst         |       2     1              2        2                    2        1      |             
      Respiratory Epithelium, Hyperplasia  | 1           1     3        1     2     2  2  2     2           1     1  2|             
      Respiratory Epithelium, Hyperplasia, |                                                                          |             
           Papillary                       |                   3  2                                                   |             
                                            __________________________________________________________________________|             
   Trachea                                 |          +           +  +     +        +        +     +     M  +  +      |             
      Inflammation, Chronic                |                                                                1         |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                              +                           |             
      Anterior, Synechia                   |                                              4                           |             
      Cornea, Inflammation, Chronic Active |                                                                          |             
      Lens, Right, Cataract                |                                              4                           |             
      Retina, Degeneration                 |                                              4                           |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                            +                                             |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |       +  +  +  +  +  +  +     +     +  +     +  +     +  +  +  +  +  +  +|             
      Bacterium                            |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                        2                                 |             
      Inflammation, Acute, Multifocal,     |                                                                          |             
           Suppurative                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  71                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 6| 7| 6| 5| 4| 6| 5| 7| 6| 7| 6| 6| 5| 7| 7| 6| 5| 7| 5| 7| 6|             
                             DAY ON TEST   | 2| 2| 3| 3| 9| 2| 9| 5| 8| 6| 3| 2| 8| 2| 2| 9| 3| 2| 2| 8| 5| 2| 8| 1| 8|             
                                           | 9| 9| 3| 3| 5| 8| 7| 4| 4| 0| 9| 9| 9| 8| 4| 7| 9| 8| 8| 0| 4| 8| 3| 4| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    100 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Nephropathy, Chronic                 |          2  4  4  4  3        2     2  4     2  2     4  3  4  4  4  4  4|             
      Pigmentation, Diffuse                |                                     3                                    |             
      Pigmentation, Multifocal             |                                                                          |             
      Cortex, Cyst                         |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |          +           +  +     +        +        +           +  +  +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  72                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 4| 7| 3| 5| 6| 7| 6| 4| 7| 6| 4| 6| 6| 7| 5| 7| 7| 6| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 5| 7| 3| 9| 9| 1| 2| 8| 6| 3| 9| 9| 6| 1| 0| 1| 3| 3| 2| 3| 2| 3| 3|            |
                                           | 0| 7| 8| 9| 0| 3| 3| 1| 9| 7| 5| 0| 4| 9| 6| 3| 0| 9| 0| 0| 7| 0| 3| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    100 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |          +     +              +        +           +                     |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |          +     +              +        +           +                     |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |          M     +              A        M           +                     |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |          +     +              A        +           +                     |  13        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |          +     +              A        +           +                     |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |          +     +              +        +           +                     |  16        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |          +     +              A        +           +                     |  14        |
      Inflammation, Acute, Multifocal      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |          +     M              A        +           +                     |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |          +     +              A        +           +                     |  13        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +     +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +|  42        |
      Angiectasis, Focal                   |                         3                                                |      3  2.3|
      Basophilic Focus                     |                                                       X                  |      4     |
      Basophilic Focus, Multiple           |                         X                                X               |      3     |
      Congestion                           |                                                                          |      2  3.5|
      Cytomegaly, Focal                    |                                     2                                    |      1  2.0|
      Cytomegaly, Multifocal               |                                                    2                     |      1  2.0|
      Eosinophilic Focus                   |                                                                          |      1     |
      Fatty Change, Diffuse                |                                                                          |      3  3.0|
      Fatty Change, Focal                  |                                                                          |      1  3.0|
      Fatty Change, Multifocal             |    3                                                                     |      3  2.0|
      Hepatodiaphragmatic Nodule           |    X                                                                    X|      3     |
      Hepatodiaphragmatic Nodule, Multiple |                                  X                                       |      1     |
      Mitotic Alteration                   |                                                    2                     |      2  1.5|
      Necrosis, Focal                      |                                        2                                 |      1  2.0|
      Necrosis, Multifocal                 |          1                 2                                             |      3  1.7|
      Pigmentation, Multifocal             |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic, Multifocal|                      2                                                   |      1  2.0|
      Bile Duct, Hyperplasia, Multifocal   | 3              1  2  1  2  2                 2     2  1  2  3  3        2|     23  2.0|
      Centrilobular, Degeneration, Diffuse |          2        2                          2                           |      5  2.2|
      Centrilobular, Fatty Change, Diffuse |                                        4                                 |      2  3.5|
      Centrilobular, Necrosis, Multifocal  |                                                                   3      |      1  3.0|
      Periportal, Fatty Change, Diffuse    |                                                                          |      1  2.0|
      Portal, Fibrosis, Multifocal         |                                                                          |      1  2.0|
      Portal, Inflammation, Chronic Active,|                                                                          |            |
           Multifocal                      |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                            +                    +        +               |   4        |
      Artery, Ectasia, Multifocal          |                                                 4                        |      1  4.0|
      Artery, Inflammation, Chronic,       |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  73                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 4| 7| 3| 5| 6| 7| 6| 4| 7| 6| 4| 6| 6| 7| 5| 7| 7| 6| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 5| 7| 3| 9| 9| 1| 2| 8| 6| 3| 9| 9| 6| 1| 0| 1| 3| 3| 2| 3| 2| 3| 3|            |
                                           | 0| 7| 8| 9| 0| 3| 3| 1| 9| 7| 5| 0| 4| 9| 6| 3| 0| 9| 0| 0| 7| 0| 3| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    100 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
          Multifocal                       |                                                 4                        |      1  4.0|
      Artery, Mineralization, Multifocal   |                                                 4                        |      1  4.0|
      Fat, Necrosis, Focal                 |                                                          4               |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +     +     +     +        A  +     +        +  +           +         |  19        |
      Acinus, Atrophy, Diffuse             |                                                 4                        |      1  4.0|
      Acinus, Atrophy, Multifocal          |                                                                3         |      2  2.5|
      Artery, Ectasia, Multifocal          |                                                 4                        |      1  4.0|
      Artery, Fibrosis                     |    3                                                                     |      1  3.0|
      Artery, Inflammation, Chronic,       |                                                                          |            |
          Multifocal                       |                                                 4                        |      1  4.0|
      Artery, Mineralization, Multifocal   |                                                 4                        |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                      +   |   1        |
      Inflammation, Chronic Active,        |                                                                          |            |
          Multifocal                       |                                                                      3   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |          +     +           +  +        +        +  +                     |  18        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |          +     +              +        +           +                     |  15        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |          +     +              A        +           M                     |  13        |
      Inflammation, Chronic Active         |                                                                          |      2  3.5|
      Ulcer                                |                                                                          |      1  4.0|
      Epithelium, Hyperplasia              |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |          +     +              A        +           +                     |  14        |
      Infiltration Cellular, Lymphocyte    |                                                    2                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                 +                        |   3        |
      Dysplasia                            |                                                 1                        |      3  1.7|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |          +     +              M        +           +                     |  14        |
      Cardiomyopathy                       |          1     1                                   2                     |     10  2.1|
      Atrium Left, Thrombosis              |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |    +     +  +  +           +  +  +     +           +  +              +   |  24        |
      Capsule, Accessory Adrenal Cortical  |                                                                          |            |
          Nodule                           |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |          +  +  +           +  A        +           +  +              +   |  20        |
      Degeneration, Diffuse, Fatty         |                            1           3                                 |      5  2.2|
      Degeneration, Fatty, Focal           |                                                    1                     |      4  2.0|
      Degeneration, Fatty, Multifocal      |             2                                                            |      1  2.0|
      Hyperplasia, Focal                   |                                                       2                  |      2  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  74                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 4| 7| 3| 5| 6| 7| 6| 4| 7| 6| 4| 6| 6| 7| 5| 7| 7| 6| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 5| 7| 3| 9| 9| 1| 2| 8| 6| 3| 9| 9| 6| 1| 0| 1| 3| 3| 2| 3| 2| 3| 3|            |
                                           | 0| 7| 8| 9| 0| 3| 3| 1| 9| 7| 5| 0| 4| 9| 6| 3| 0| 9| 0| 0| 7| 0| 3| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    100 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Hypertrophy, Focal                   |          2                                                               |      2  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    +     +  +  +           +  A  +     +           +  +              +   |  21        |
      Hyperplasia, Focal                   |                                                    2                     |      3  2.3|
      Hyperplasia, Multifocal              |                                        2                             2   |      2  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |          +     +              A  +     +        +  +           +         |  16        |
      Hyperplasia, Multifocal              |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |          +     +              +        +           +                     |  14        |
      Hyperplasia                          |                                        2                                 |      2  2.5|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +     +  +     +           +  A  +  +  +  +  +  +  +     +     +     +   |  35        |
      Pars Distalis, Angiectasis           |                                                                          |      1  2.0|
      Pars Distalis, Cyst                  | 2                                                  1                     |      4  2.0|
      Pars Distalis, Hyperplasia, Focal    |                                     2              2                     |      3  2.3|
      Pars Distalis, Hyperplasia           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +     +     +           +  +        +           +  +        +     +   |  20        |
      C-Cell, Hyperplasia, Focal           |                                                                          |      1  2.0|
      C-Cell, Hyperplasia, Multifocal      |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |          +     +              +        +        +  +              +      |  16        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |          +  +  +        +     +        +           +                     |  18        |
      Abscess                              |                         4                                                |      2  4.0|
      Ectasia                              |                                                                          |      2  3.5|
      Inflammation, Granulomatous,         |                                                                          |            |
          Multifocal                       |          2                                                               |      4  1.8|
                                            __________________________________________________________________________|____________|
   Prostate                                |    +     M     +              +     +  +  +        +                     |  18        |
      Hyperplasia, Multifocal              |                                                                          |      2  3.5|
      Inflammation, Chronic Active         |                                     2              2                     |      6  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |    +     M     +              M     +     +        M                 +   |  13        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +     +  +  +        +  +  +  +  +  +  +     +  +     +  +  +  +  +  +|  42        |
      Hemorrhage                           |                         4                                                |      1  4.0|
      Mineralization, Multifocal           |                                                             2            |      1  2.0|
      Arteriole, Inflammation              |                                                 2                        |      2  2.5|
      Interstitial Cell, Hyperplasia       |                                        2           2                     |      4  2.3|
      Seminiferous Tubule, Atrophy         |                         3           3  2  2     2           3            |     11  2.7|
      Serosa, Necrosis, Focal              |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  75                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 4| 7| 3| 5| 6| 7| 6| 4| 7| 6| 4| 6| 6| 7| 5| 7| 7| 6| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 5| 7| 3| 9| 9| 1| 2| 8| 6| 3| 9| 9| 6| 1| 0| 1| 3| 3| 2| 3| 2| 3| 3|            |
                                           | 0| 7| 8| 9| 0| 3| 3| 1| 9| 7| 5| 0| 4| 9| 6| 3| 0| 9| 0| 0| 7| 0| 3| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    100 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |          +     +        +     A        +           +                     |  15        |
      Atrophy                              |                                                                          |      1  3.0|
      Hyperplasia                          |                         2                                                |      2  2.0|
      Metaplasia, Osseous                  |                         1                                                |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +     +     +     +  +  +  +        +     +  +  +                     |  27        |
      Mediastinal, Hemorrhage              |    4                                                                     |      2  3.0|
      Pancreatic, Hemorrhage               |    1                                                                     |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +        M     M           +  A        M        +  +                     |  14        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia, Plasma Cell             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +        M     +        +  +  A        +     +     +                     |  17        |
      Hemorrhage                           |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +        +     +  +  +  +  +  +     +  +  +  +     +  +  +  +  +         |  35        |
      Congestion                           |                                                                          |      1  4.0|
      Fibrosis, Focal                      |                                                          3               |      2  2.5|
      Fibrosis, Multifocal                 |                                                             4            |      2  3.5|
      Hematopoietic Cell Proliferation     |                                           4        3                     |      2  3.5|
      Pigmentation, Hemosiderin            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |          +     M           +  M        +           +                     |  14        |
      Angiectasis, Multifocal              |                                        2                                 |      1  2.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia, Tubular                 |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |          +     M              +  +     +        +  +                 +   |  20        |
      Ectasia, Diffuse                     |                                                 3                        |      4  3.0|
      Ectasia, Multifocal                  |                                        2                                 |      7  2.4|
      Hyperplasia, Diffuse                 |                                                                      2   |      2  2.0|
      Inflammation, Granulomatous          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +        +     +              +  +  +  +           +                     |  23        |
      Cyst Epithelial Inclusion            | X                                                                        |      3  4.0|
      Hyperkeratosis                       |                                                                          |      2  3.5|
      Hyperplasia, Squamous                |                                                                          |      1  2.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic Active                  |                                                                          |      2  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |          +  +  +              +        +        +  +                     |  18        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  76                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 4| 7| 3| 5| 6| 7| 6| 4| 7| 6| 4| 6| 6| 7| 5| 7| 7| 6| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 5| 7| 3| 9| 9| 1| 2| 8| 6| 3| 9| 9| 6| 1| 0| 1| 3| 3| 2| 3| 2| 3| 3|            |
                                           | 0| 7| 8| 9| 0| 3| 3| 1| 9| 7| 5| 0| 4| 9| 6| 3| 0| 9| 0| 0| 7| 0| 3| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    100 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
      Fibrous Osteodystrophy               |             3                                   4                        |      3  3.3|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                +        +                 +                    +         |   4        |
      Hemorrhage, Acute                    |                         4                                      4         |      2  4.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |          +     +              +        +           +                     |  15        |
      Compression                          |                                                                          |      5     |
      Hydrocephalus                        |                                                                          |      2  2.5|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Multifocal, Mixed Cell          |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |          +     M              M                    M                     |   5        |
      Inflammation, Chronic Active, Focal  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                  2                                       |      1  2.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Multifocal                      |                                                                          |      2  3.0|
      Interstitium, Inflammation, Chronic, |                                                                          |            |
           Diffuse                         |                                                 2                        |      1  2.0|
      Interstitium, Inflammation, Chronic, |                                                                          |            |
           Multifocal                      |                                           1                              |      4  1.8|
      Interstitium, Mineralization,        |                                                                          |            |
          Multifocal                       |                                                 3                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lumen, Exudate                       |                               2  4     3                    2            |      5  2.4|
      Lumen, Foreign Body                  |                               1              1              1            |      5  1.4|
      Mucosa, Inflammation, Chronic        |                                                 1                        |      4  1.8|
      Mucosa, Inflammation, Chronic Active |                   2              4     1     2              1  2         |      9  2.0|
      Mucosa, Thrombosis, Multifocal       |                   1        4                                      4      |      5  2.8|
      Nasolacrimal Duct, Exudate           |    3                                            1                        |      3  2.7|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute                           |                                                                          |      1  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic                         |    1  1           1              2        1        1  1     1           1|     16  1.3|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic Active                  |                                                 1                        |      1  1.0|
      Olfactory Epithelium, Atrophy        |                                                 1                        |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  77                                                               
NTP Experiment-Test: 05070-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:28:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 4| 7| 3| 5| 6| 7| 6| 4| 7| 6| 4| 6| 6| 7| 5| 7| 7| 6| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 5| 7| 3| 9| 9| 1| 2| 8| 6| 3| 9| 9| 6| 1| 0| 1| 3| 3| 2| 3| 2| 3| 3|            |
                                           | 0| 7| 8| 9| 0| 3| 3| 1| 9| 7| 5| 0| 4| 9| 6| 3| 0| 9| 0| 0| 7| 0| 3| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    100 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Olfactory Epithelium, Cyst           |                         1                    1        1                  |      4  1.0|
      Olfactory Epithelium, Erosion        |    1  1                                            1                     |      8  1.4|
      Olfactory Epithelium, Metaplasia     |                                        2                       1        1|      6  1.3|
      Respiratory Epithelium, Cyst         | 1     1                 1                             2     2  1  2      |     13  1.5|
      Respiratory Epithelium, Hyperplasia  |    2        1     1  2              2  1  3  1  1           1  1     1   |     24  1.5|
      Respiratory Epithelium, Hyperplasia, |                                                                          |            |
           Papillary                       |                   2              2                          2            |      5  2.2|
                                            __________________________________________________________________________|____________|
   Trachea                                 |          +     +              +        +           +                     |  14        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                 +                        |   2        |
      Anterior, Synechia                   |                                                                          |      1  4.0|
      Cornea, Inflammation, Chronic Active |                                                 4                        |      1  4.0|
      Lens, Right, Cataract                |                                                                          |      1  4.0|
      Retina, Degeneration                 |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +     +  +  +     +  +     A  +     +  +  +  +  +  +     +     +  +   |  35        |
      Bacterium                            |    4                                                                     |      1  4.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  2.0|
      Inflammation, Acute, Multifocal,     |                                                                          |            |
           Suppurative                     |    4                                                                     |      1  4.0|
      Nephropathy, Chronic                 |    4     2  4  1     3  4        4     4  2  2  4  1  4           4  4   |     32  3.2|
      Pigmentation, Diffuse                |                                                             1            |      2  2.0|
      Pigmentation, Multifocal             |                2                                                         |      1  2.0|
      Cortex, Cyst                         |                                           3                              |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |          M     +              +        +           M                     |  12        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  78                                                               
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           

--multipart-boundary
Content-type: text/plain
Range: bytes 709506-709506/709506


--multipart-boundary--