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https://ntp.niehs.nih.gov/go/3804

TDMS Study 05087-01 Pathology Tables



                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                            TRIAMTERENE


NTP Experiment-Test: 05087-01                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/11/94
Route: DOSED FEED                                                                                                 Time: 11:14:42




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  396-01-0

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05087-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 11:14:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 PPM        150 PPM      300 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          70           70           70           70                                     
  Scheduled Sacrifice                                 20           20           20           20                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                17           11           12           18                                     
    Natural Death                                      4            5            4            3                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                29           34           34           29                                     
  Animals Examined Microscopically                    70           61           63           70                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (70)         (47)         (50)         (70)                                   
      Ulcer                                                         1 (2%)                                                          
   Intestine Large, Colon                             (70)         (50)         (50)         (69)                                   
      Parasite Metazoan                                2 (3%)       6 (12%)      3 (6%)       4 (6%)                                
   Intestine Large, Rectum                            (70)         (50)         (50)         (69)                                   
      Parasite Metazoan                                2 (3%)                                 1 (1%)                                
   Intestine Small, Duodenum                          (70)         (50)         (50)         (70)                                   
      Ulcer                                                         1 (2%)                                                          
   Liver                                              (70)         (61)         (61)         (70)                                   
      Angiectasis, Focal                               1 (1%)       5 (8%)                                                          
      Basophilic Focus                                42 (60%)     45 (74%)     37 (61%)     38 (54%)                               
      Clear Cell Focus                                 3 (4%)       3 (5%)       4 (7%)       9 (13%)                               
      Degeneration, Cystic                                                                    1 (1%)                                
      Eosinophilic Focus                                                         1 (2%)       3 (4%)                                
      Fatty Change                                     1 (1%)                    1 (2%)       3 (4%)                                
      Hepatodiaphragmatic Nodule                       2 (3%)       7 (11%)      1 (2%)       7 (10%)                               
      Hyperplasia                                      1 (1%)       3 (5%)       3 (5%)       2 (3%)                                
      Hyperplasia, Histiocytic, Lymphoid               1 (1%)                                                                       
      Inflammation, Granulomatous                     23 (33%)     15 (25%)     22 (36%)     14 (20%)                               
      Mixed Cell Focus                                 2 (3%)       2 (3%)       9 (15%)     13 (19%)                               
      Necrosis, Coagulative                            1 (1%)       2 (3%)                    1 (1%)                                
      Vacuolization Cytoplasmic, Focal                              1 (2%)                                                          
      Periportal, Inflammation, Chronic                1 (1%)                                 1 (1%)                                
      Serosa, Hemorrhage                                                                      1 (1%)                                
   Mesentery                                          (4)          (2)          (4)          (1)                                    
      Inflammation, Chronic                            1 (25%)      1 (50%)      1 (25%)                                            
      Fat, Necrosis                                    3 (75%)                   2 (50%)                                            
   Pancreas                                           (70)         (50)         (50)         (70)                                   
      Inflammation, Chronic                            1 (1%)                                                                       
      Acinus, Atrophy                                 16 (23%)      6 (12%)     11 (22%)     15 (21%)                               
      Artery, Inflammation, Chronic                    1 (1%)       1 (2%)                    1 (1%)                                
   Salivary Glands                                    (69)         (50)         (49)         (70)                                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05087-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 11:14:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 PPM        150 PPM      300 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Inflammation, Acute                                                                     1 (1%)                                
   Stomach, Forestomach                               (70)         (50)         (50)         (70)                                   
      Acanthosis                                       2 (3%)                                                                       
      Cyst                                                          1 (2%)                                                          
      Hyperkeratosis                                   2 (3%)                                                                       
      Inflammation, Chronic                                                                   2 (3%)                                
      Ulcer                                            2 (3%)       2 (4%)       1 (2%)       3 (4%)                                
      Epithelium, Acanthosis, Diffuse                                                         1 (1%)                                
      Epithelium, Hyperkeratosis, Diffuse                                                     1 (1%)                                
   Stomach, Glandular                                 (70)         (50)         (50)         (70)                                   
      Inflammation, Chronic                            1 (1%)                                 1 (1%)                                
      Ulcer                                            3 (4%)       3 (6%)       3 (6%)       3 (4%)                                
      Mucosa, Mineralization                                                     2 (4%)                                             
   Tongue                                             (1)                       (1)                                                 
      Acanthosis                                       1 (100%)                  1 (100%)                                           
      Hyperkeratosis                                   1 (100%)                  1 (100%)                                           
   Tooth                                                                        (2)          (1)                                    
      Peridontal Tissue, Inflammation, Chronic                                   2 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (1)                                                                           
      Aorta, Inflammation, Chronic                     1 (100%)                                                                     
   Heart                                              (70)         (50)         (50)         (70)                                   
      Atrium, Thrombosis                                            2 (4%)                                                          
      Endothelium, Hyperplasia                         1 (1%)                                                                       
      Myocardium, Degeneration                        32 (46%)     39 (78%)     30 (60%)     27 (39%)                               
      Myocardium, Degeneration, Multifocal             3 (4%)                                 3 (4%)                                
      Myocardium, Inflammation, Chronic, Multifocal    1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (70)         (50)         (50)         (70)                                   
      Hematopoietic Cell Proliferation                 1 (1%)                                                                       
      Hyperplasia                                     13 (19%)     18 (36%)     10 (20%)     16 (23%)                               
      Hyperplasia, Nodular                             1 (1%)                                                                       
   Adrenal Gland, Medulla                             (70)         (50)         (50)         (70)                                   
      Hematopoietic Cell Proliferation                 1 (1%)                                                                       
      Hyperplasia                                      6 (9%)       6 (12%)                   5 (7%)                                
   Pituitary Gland                                    (70)         (53)         (52)         (69)                                   
      Necrosis, Liquifactive                                                     1 (2%)                                             
      Pars Distalis, Angiectasis                       1 (1%)       3 (6%)       1 (2%)                                             
      Pars Distalis, Cyst                              6 (9%)       1 (2%)       4 (8%)       6 (9%)                                
      Pars Distalis, Degeneration, Cystic                                                     1 (1%)                                
      Pars Distalis, Hyperplasia                      12 (17%)     12 (23%)      9 (17%)     14 (20%)                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05087-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 11:14:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 PPM        150 PPM      300 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Pars Intermedia, Hyperplasia                     1 (1%)                                                                       
   Thyroid Gland                                      (70)         (50)         (50)         (70)                                   
      C-Cell, Hyperplasia                             52 (74%)     32 (64%)     37 (74%)     43 (61%)                               
      Follicle, Dilatation                                          2 (4%)       2 (4%)       2 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (62)         (49)         (50)         (67)                                   
      Inflammation, Chronic                           16 (26%)     17 (35%)     28 (56%)     22 (33%)                               
      Inflammation, Suppurative                        1 (2%)                                                                       
   Ovary                                              (70)         (50)         (50)         (70)                                   
      Cyst                                             1 (1%)       3 (6%)       1 (2%)       2 (3%)                                
      Inflammation, Granulomatous                      1 (1%)                                                                       
      Follicle, Cyst                                                             2 (4%)                                             
   Uterus                                             (70)         (51)         (50)         (70)                                   
      Dilatation                                                    2 (4%)       1 (2%)       1 (1%)                                
      Hemorrhage                                                                 1 (2%)                                             
      Cervix, Epithelium, Hyperplasia                  2 (3%)                                                                       
      Endometrium, Hyperplasia, Cystic                 2 (3%)       2 (4%)       1 (2%)                                             
   Vagina                                                          (1)                                                              
      Infiltration Cellular, Polymorphonuclear                      1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (70)         (50)         (50)         (70)                                   
      Femoral, Atrophy                                 1 (1%)                                                                       
      Femoral, Hyperplasia, Re Cell                   10 (14%)                                9 (13%)                               
      Femoral, Myelofibrosis                                                                  1 (1%)                                
   Lymph Node                                         (70)         (51)         (50)         (70)                                   
      Inguinal, Sinus, Ectasia                         1 (1%)                                                                       
      Lumbar, Sinus, Ectasia                                                                  1 (1%)                                
      Mediastinal, Sinus, Ectasia                      2 (3%)                    1 (2%)                                             
      Pancreatic, Hematopoietic Cell Proliferation                                            1 (1%)                                
      Pancreatic, Hyperplasia, Plasma Cell                                                    1 (1%)                                
      Pancreatic, Infiltration Cellular, Histiocyte                                           1 (1%)                                
   Lymph Node, Mandibular                             (68)         (51)         (49)         (70)                                   
      Hyperplasia, Plasma Cell                                      2 (4%)       1 (2%)                                             
      Sinus, Ectasia                                                2 (4%)       2 (4%)       1 (1%)                                
   Lymph Node, Mesenteric                             (68)         (48)         (50)         (68)                                   
      Infiltration Cellular, Histiocyte                9 (13%)                               10 (15%)                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05087-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 11:14:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 PPM        150 PPM      300 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Sinus, Ectasia                                   3 (4%)                    1 (2%)       4 (6%)                                
   Spleen                                             (70)         (50)         (50)         (70)                                   
      Depletion Lymphoid                               1 (1%)                    1 (2%)                                             
      Fibrosis                                                      1 (2%)                                                          
      Hematopoietic Cell Proliferation                 4 (6%)       1 (2%)                    3 (4%)                                
      Hyperplasia, Lymphoid                            1 (1%)                                                                       
      Infarct                                          2 (3%)       2 (4%)                                                          
      Inflammation, Granulomatous                      1 (1%)                    2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (67)         (49)         (49)         (66)                                   
      Hyperplasia, Cystic                             17 (25%)     25 (51%)     22 (45%)     24 (36%)                               
   Skin                                               (70)         (50)         (50)         (70)                                   
      Ulcer                                                                                   1 (1%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (70)         (50)         (50)         (70)                                   
      Osteopetrosis                                    1 (1%)       5 (10%)      1 (2%)                                             
      Femur, Osteopetrosis                             2 (3%)                                 1 (1%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (70)         (50)         (50)         (70)                                   
      Infarct                                          3 (4%)       2 (4%)       1 (2%)                                             
      Hypothalamus, Compression                       10 (14%)      7 (14%)     11 (22%)     14 (20%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (70)         (50)         (50)         (70)                                   
      Abscess                                                                                 1 (1%)                                
      Foreign Body                                                               1 (2%)       1 (1%)                                
      Inflammation, Granulomatous                                                2 (4%)                                             
      Alveolus, Inflammation, Subacute                              2 (4%)       1 (2%)       1 (1%)                                
      Interstitium, Inflammation, Chronic              3 (4%)       1 (2%)       3 (6%)       2 (3%)                                
      Peribronchiolar, Inflammation, Chronic,                                                                                       
          Multifocal                                   1 (1%)                                                                       
      Peribronchiolar, Inflammation, Chronic                                                                                        
          Active, Multifocal                                                                  1 (1%)                                
   Nose                                               (70)         (50)         (50)         (70)                                   
      Nares, Inflammation, Suppurative                              1 (2%)                    3 (4%)                                
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05087-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 11:14:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 PPM        150 PPM      300 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)          (1)          (3)          (3)                                    
      Hemorrhage                                                                 1 (33%)                                            
      Lens, Cataract                                   1 (50%)      1 (100%)     2 (67%)      1 (33%)                               
   Harderian Gland                                    (8)                                    (3)                                    
      Inflammation, Chronic, Focal                                                            2 (67%)                               
      Inflammation, Chronic, Multifocal                7 (88%)                                                                      
      Inflammation, Chronic Active, Multifocal         1 (13%)                                                                      
      Inflammation, Suppurative                                                               1 (33%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (70)         (60)         (60)         (70)                                   
      Cyst                                                                       1 (2%)                                             
      Hydronephrosis                                                                          1 (1%)                                
      Nephropathy                                     38 (54%)     45 (75%)     45 (75%)     45 (64%)                               
      Nephropathy, Multifocal                          7 (10%)      8 (13%)      5 (8%)       8 (11%)                               
      Renal Tubule, Mineralization, Multifocal         2 (3%)                                                                       
   Urinary Bladder                                    (69)         (49)         (50)         (70)                                   
      Transitional Epithelium, Hyperplasia                                                    1 (1%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05087-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 11:14:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 PPM        150 PPM      300 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          70           70           70           70                                     
  Scheduled Sacrifice                                 20           20           20           20                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                18           20           18           17                                     
    Natural Death                                      4            5           13            6                                     
    Drowned                                            3                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                25           25           19           27                                     
  Animals Examined Microscopically                    70           60           61           70                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (70)         (51)         (50)         (70)                                   
      Dilatation                                                                 1 (2%)                                             
   Intestine Large, Cecum                             (69)         (49)         (49)         (66)                                   
      Edema                                                         1 (2%)                                                          
      Inflammation, Chronic                            1 (1%)                                                                       
      Parasite Metazoan                                                          2 (4%)                                             
      Ulcer                                            1 (1%)                                 1 (2%)                                
   Intestine Large, Colon                             (70)         (51)         (48)         (68)                                   
      Edema                                                                                   1 (1%)                                
      Mineralization                                   1 (1%)                                                                       
      Parasite Metazoan                                3 (4%)       1 (2%)       5 (10%)      2 (3%)                                
   Intestine Large, Rectum                            (69)         (48)         (49)         (67)                                   
      Edema                                            1 (1%)       1 (2%)                                                          
      Mineralization                                   1 (1%)                                                                       
      Parasite Metazoan                                1 (1%)       3 (6%)       2 (4%)       2 (3%)                                
   Intestine Small, Duodenum                          (70)         (50)         (50)         (68)                                   
      Ulcer                                                         1 (2%)       1 (2%)                                             
   Intestine Small, Ileum                             (69)         (50)         (48)         (66)                                   
      Mineralization                                   1 (1%)                                                                       
   Intestine Small, Jejunum                           (68)         (50)         (49)         (67)                                   
      Ulcer                                                         1 (2%)                                                          
   Liver                                              (70)         (56)         (55)         (69)                                   
      Angiectasis, Focal                                            2 (4%)                    1 (1%)                                
      Bacterium                                        1 (1%)                    1 (2%)                                             
      Basophilic Focus                                16 (23%)     14 (25%)      5 (9%)      23 (33%)                               
      Clear Cell Focus                                 4 (6%)       6 (11%)      5 (9%)      11 (16%)                               
      Degeneration, Cystic                            10 (14%)      7 (13%)     10 (18%)      8 (12%)                               
      Eosinophilic Focus                               2 (3%)       3 (5%)       2 (4%)       9 (13%)                               
      Fatty Change                                                  2 (4%)                                                          
      Fibrosis, Focal                                                                         1 (1%)                                
      Hepatodiaphragmatic Nodule                                    4 (7%)       4 (7%)       3 (4%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05087-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 11:14:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 PPM        150 PPM      300 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Hyperplasia                                                   3 (5%)       5 (9%)      10 (14%)                               
      Inflammation, Granulomatous                      7 (10%)                   5 (9%)       2 (3%)                                
      Mixed Cell Focus                                              6 (11%)      9 (16%)     14 (20%)                               
      Necrosis, Coagulative                            2 (3%)       2 (4%)       4 (7%)       1 (1%)                                
      Periportal, Inflammation, Chronic                2 (3%)                                                                       
      Sinusoid, Congestion                                          1 (2%)                                                          
   Mesentery                                          (4)          (4)          (4)          (10)                                   
      Inflammation, Chronic                            1 (25%)                                2 (20%)                               
      Pigmentation, Hemosiderin                                                               1 (10%)                               
      Fat, Necrosis                                    3 (75%)      2 (50%)      3 (75%)      5 (50%)                               
   Pancreas                                           (70)         (51)         (50)         (68)                                   
      Ectopic Tissue                                                             1 (2%)       1 (1%)                                
      Acinus, Atrophy                                 16 (23%)     19 (37%)     17 (34%)     17 (25%)                               
      Artery, Inflammation, Chronic                   14 (20%)      6 (12%)     11 (22%)     12 (18%)                               
      Duct, Ectasia                                                                           1 (1%)                                
   Salivary Glands                                    (70)         (50)         (50)         (70)                                   
      Acinus, Parotid Gland, Cytoplasmic                                                                                            
          Alteration, Focal                                                                   1 (1%)                                
      Acinus, Parotid Gland, Vacuolization                                                                                          
          Cytoplasmic, Focal                                                                  1 (1%)                                
      Periductular, Fibrosis                                                     1 (2%)                                             
   Stomach, Forestomach                               (70)         (51)         (51)         (69)                                   
      Acanthosis                                                                 3 (6%)       4 (6%)                                
      Hyperkeratosis                                                             3 (6%)       4 (6%)                                
      Inflammation, Chronic                                         2 (4%)       1 (2%)       2 (3%)                                
      Inflammation, Chronic, Focal                     1 (1%)                                                                       
      Inflammation, Focal, Subacute                    1 (1%)                                                                       
      Mineralization                                   2 (3%)                    1 (2%)                                             
      Ulcer                                            2 (3%)       6 (12%)      2 (4%)       3 (4%)                                
      Epithelium, Acanthosis, Focal                    2 (3%)                                                                       
      Epithelium, Hyperkeratosis, Focal                2 (3%)                    1 (2%)                                             
   Stomach, Glandular                                 (70)         (51)         (50)         (68)                                   
      Inflammation, Chronic                            4 (6%)                    1 (2%)                                             
      Inflammation, Focal, Subacute                    1 (1%)                                                                       
      Ulcer                                            8 (11%)      6 (12%)      4 (8%)       3 (4%)                                
      Mucosa, Hyperplasia, Focal                       1 (1%)                                                                       
      Mucosa, Mineralization                           7 (10%)      3 (6%)       7 (14%)      4 (6%)                                
   Tongue                                             (1)                       (1)          (1)                                    
      Acanthosis                                       1 (100%)                                                                     
      Hyperkeratosis                                   1 (100%)                                                                     
   Tooth                                                           (1)          (1)          (1)                                    
      Peridontal Tissue, Inflammation, Chronic                                   1 (100%)                                           
      Pulp, Inflammation, Suppurative                               1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05087-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 11:14:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 PPM        150 PPM      300 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (1)          (3)          (3)          (3)                                    
      Aorta, Inflammation, Chronic                                                            1 (33%)                               
      Aorta, Inflammation, Chronic, Focal                                                     1 (33%)                               
      Aorta, Mineralization                            1 (100%)     3 (100%)     3 (100%)     1 (33%)                               
   Heart                                              (70)         (60)         (60)         (70)                                   
      Atrium, Dilatation                               1 (1%)                                                                       
      Atrium, Thrombosis                               1 (1%)                    1 (2%)                                             
      Coronary Artery, Inflammation, Chronic                                     1 (2%)                                             
      Myocardium, Degeneration                        34 (49%)     44 (73%)     42 (70%)     36 (51%)                               
      Myocardium, Degeneration, Multifocal             6 (9%)       7 (12%)      6 (10%)     10 (14%)                               
      Myocardium, Inflammation, Chronic, Multifocal    9 (13%)                                3 (4%)                                
      Myocardium, Inflammation, Suppurative            1 (1%)                                                                       
      Myocardium, Mineralization                       2 (3%)       2 (3%)       3 (5%)       3 (4%)                                
      Valve, Inflammation, Chronic Active              1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (70)         (51)         (50)         (70)                                   
      Angiectasis                                                   1 (2%)                                                          
      Ectopic Tissue                                                1 (2%)                                                          
      Hemorrhage                                       1 (1%)                                                                       
      Hyperplasia                                      8 (11%)     14 (27%)     18 (36%)     14 (20%)                               
      Hyperplasia, Nodular                             1 (1%)                                                                       
   Adrenal Gland, Medulla                             (70)         (51)         (50)         (69)                                   
      Hyperplasia                                     12 (17%)     14 (27%)     16 (32%)      6 (9%)                                
      Infarct                                          1 (1%)       1 (2%)                                                          
   Parathyroid Gland                                  (64)         (47)         (50)         (68)                                   
      Hyperplasia                                      4 (6%)       3 (6%)      11 (22%)      8 (12%)                               
   Pituitary Gland                                    (70)         (52)         (49)         (69)                                   
      Abscess                                                                                 1 (1%)                                
      Pars Distalis, Cyst                                           2 (4%)                    1 (1%)                                
      Pars Distalis, Hyperplasia                      10 (14%)      5 (10%)      7 (14%)      6 (9%)                                
      Pars Distalis, Hyperplasia, Nodular                                                     1 (1%)                                
      Pars Intermedia, Cyst                                         1 (2%)                                                          
   Thyroid Gland                                      (70)         (50)         (50)         (69)                                   
      C-Cell, Hyperplasia                             43 (61%)     32 (64%)     28 (56%)     44 (64%)                               
      Follicle, Dilatation                             3 (4%)       2 (4%)                    1 (1%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05087-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 11:14:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 PPM        150 PPM      300 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (70)         (51)         (50)         (69)                                   
      Granuloma Sperm                                               1 (2%)                                                          
      Inflammation, Chronic                                         1 (2%)       1 (2%)                                             
      Inflammation, Suppurative                                     1 (2%)                                                          
   Preputial Gland                                    (70)         (51)         (51)         (67)                                   
      Hyperplasia                                                   3 (6%)       3 (6%)                                             
      Inflammation, Chronic                           44 (63%)     39 (76%)     40 (78%)     47 (70%)                               
      Duct, Dilatation                                              1 (2%)                                                          
   Prostate                                           (68)         (49)         (50)         (69)                                   
      Cyst                                                                       1 (2%)                                             
      Inflammation, Chronic                            5 (7%)                                 1 (1%)                                
      Inflammation, Suppurative                       23 (34%)     17 (35%)     13 (26%)     22 (32%)                               
   Seminal Vesicle                                    (69)         (48)         (50)         (69)                                   
      Inflammation, Suppurative                        1 (1%)       2 (4%)                                                          
   Testes                                             (70)         (51)         (56)         (69)                                   
      Necrosis, Coagulative                            1 (1%)                                                                       
      Interstitial Cell, Hyperplasia                   4 (6%)       1 (2%)       1 (2%)       1 (1%)                                
      Interstitial Cell, Right, Hyperplasia                                                   1 (1%)                                
      Seminiferous Tubule, Atrophy                    12 (17%)     15 (29%)     12 (21%)      7 (10%)                               
      Seminiferous Tubule, Hypoplasia                  1 (1%)                                                                       
      Seminiferous Tubule, Right, Atrophy                                                     1 (1%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (70)         (51)         (50)         (70)                                   
      Hyperplasia, Histiocytic                                                                1 (1%)                                
   Lymph Node                                         (70)         (51)         (50)         (70)                                   
      Mediastinal, Pigmentation, Hemosiderin           1 (1%)                    1 (2%)                                             
      Mediastinal, Sinus, Ectasia                      1 (1%)       1 (2%)                    1 (1%)                                
      Renal, Ectasia                                                             2 (4%)                                             
      Renal, Sinus, Ectasia                                         1 (2%)                                                          
   Lymph Node, Mandibular                             (70)         (50)         (50)         (70)                                   
      Hyperplasia, Lymphoid                            1 (1%)                                                                       
      Hyperplasia, Plasma Cell                         1 (1%)       2 (4%)       1 (2%)                                             
      Infiltration Cellular, Histiocyte                2 (3%)                                                                       
      Sinus, Ectasia                                                1 (2%)                    2 (3%)                                
   Lymph Node, Mesenteric                             (68)         (48)         (47)         (67)                                   
      Hyperplasia, Plasma Cell                                      1 (2%)                                                          
      Infiltration Cellular, Mononuclear Cell                       1 (2%)                                                          
      Infiltration Cellular, Histiocyte                7 (10%)                   1 (2%)       5 (7%)                                
      Sinus, Ectasia                                                3 (6%)       1 (2%)       1 (1%)                                
   Spleen                                             (70)         (51)         (50)         (70)                                   
      Depletion Lymphoid                               1 (1%)                                                                       
      Fibrosis                                         4 (6%)       6 (12%)      4 (8%)       8 (11%)                               
      Hematopoietic Cell Proliferation                 1 (1%)       2 (4%)       1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05087-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 11:14:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 PPM        150 PPM      300 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
      Infarct                                          1 (1%)       1 (2%)       1 (2%)       4 (6%)                                
      Inflammation, Granulomatous                                                1 (2%)                                             
   Thymus                                             (62)         (47)         (46)         (60)                                   
      Atrophy                                                       1 (2%)                                                          
      Ectopic Parathyroid Gland                                     1 (2%)                                                          
      Ectopic Thyroid                                               1 (2%)                                                          
      Inflammation, Chronic                                         1 (2%)                                                          
      Arteriole, Giant Cell                                                                   1 (2%)                                
      Artery, Mineralization                                                     1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (38)         (35)         (57)                                   
      Hyperplasia, Cystic                             17 (34%)      5 (13%)      5 (14%)      8 (14%)                               
   Skin                                               (69)         (51)         (50)         (68)                                   
      Abscess                                          1 (1%)       2 (4%)       1 (2%)                                             
      Cyst Epithelial Inclusion                                     3 (6%)                    1 (1%)                                
      Hemorrhage                                                                              1 (1%)                                
      Ulcer                                                         1 (2%)       1 (2%)                                             
      Epidermis, Acanthosis                                         1 (2%)                    1 (1%)                                
      Epidermis, Hyperkeratosis                                     1 (2%)                    1 (1%)                                
      Hair Follicle, Hyperkeratosis                                 1 (2%)                                                          
      Sebaceous Gland, Hyperplasia                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (70)         (51)         (50)         (70)                                   
      Osteopetrosis                                                                           1 (1%)                                
      Femur, Fibrous Osteodystrophy                    4 (6%)       3 (6%)       5 (10%)      2 (3%)                                
      Femur, Osteopetrosis                                                                    1 (1%)                                
      Synovial Tissue, Inflammation, Suppurative       1 (1%)                                 1 (1%)                                
      Tarsal, Fracture Healed                                                                 1 (1%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (70)         (51)         (50)         (70)                                   
      Gliosis                                          1 (1%)                                                                       
      Hydrocephalus                                                                           1 (1%)                                
      Infarct                                          3 (4%)       1 (2%)       6 (12%)      2 (3%)                                
      Inflammation, Suppurative                                                               1 (1%)                                
      Hypothalamus, Compression                        4 (6%)       4 (8%)       2 (4%)       3 (4%)                                
   Spinal Cord                                                     (1)                                                              
      Lumbar, Atrophy                                               1 (100%)                                                        
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05087-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 11:14:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 PPM        150 PPM      300 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (70)         (51)         (50)         (70)                                   
      Inflammation, Granulomatous                                                             1 (1%)                                
      Alveolus, Hemorrhage, Multifocal                                                        1 (1%)                                
      Alveolus, Inflammation, Subacute                                           1 (2%)       2 (3%)                                
      Artery, Mineralization, Focal                                                           1 (1%)                                
      Bronchus, Foreign Body, Single                   1 (1%)                                                                       
      Bronchus, Epithelium, Hyperplasia, Multifocal    1 (1%)                                                                       
      Interstitium, Inflammation, Chronic              2 (3%)       2 (4%)       3 (6%)       4 (6%)                                
      Interstitium, Inflammation, Chronic, Focal                                              1 (1%)                                
      Interstitium, Mineralization                     2 (3%)       2 (4%)       2 (4%)                                             
      Peribronchial, Inflammation, Chronic, Focal                                             1 (1%)                                
      Peribronchiolar, Inflammation, Chronic,                                                                                       
          Multifocal                                   4 (6%)                                                                       
   Nose                                               (70)         (51)         (50)         (70)                                   
      Fungus                                           1 (1%)                                 1 (1%)                                
      Nares, Foreign Body                                                        1 (2%)                                             
      Nares, Inflammation, Suppurative                 3 (4%)                    2 (4%)       2 (3%)                                
      Sinus, Inflammation, Chronic Active              1 (1%)                                                                       
   Trachea                                            (70)         (51)         (50)         (70)                                   
      Inflammation, Subacute                                                     1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (2)                                    (1)                                    
      Middle Ear, Abscess                              1 (50%)                                                                      
   Eye                                                (3)          (2)          (1)          (2)                                    
      Phthisis Bulbi                                   1 (33%)                                                                      
      Cornea, Inflammation, Necrotizing                                          1 (100%)                                           
      Cornea, Mineralization                           1 (33%)                                1 (50%)                               
      Lens, Cataract                                   1 (33%)      1 (50%)                   1 (50%)                               
      Sclera, Mineralization                                        1 (50%)                                                         
   Harderian Gland                                    (2)                                    (1)                                    
      Inflammation, Chronic, Multifocal                2 (100%)                               1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (70)         (51)         (52)         (70)                                   
      Cyst                                             1 (1%)       2 (4%)       2 (4%)       1 (1%)                                
      Hydronephrosis                                   1 (1%)                                                                       
      Inflammation, Suppurative                        1 (1%)                                                                       
      Nephropathy                                     47 (67%)     49 (96%)     50 (96%)     49 (70%)                               
      Nephropathy, Multifocal                         10 (14%)      1 (2%)       2 (4%)      10 (14%)                               
      Interstitial Tissue, Inflammation, Chronic,                                                                                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05087-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 11:14:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 PPM        150 PPM      300 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
           Multifocal                                  4 (6%)                                                                       
   Urinary Bladder                                    (69)         (48)         (50)         (67)                                   
      Ectasia                                                                    1 (2%)                                             
      Hemorrhage                                                                 1 (2%)                                             
      Inflammation, Necrotizing                        1 (1%)                                                                       
      Inflammation, Suppurative                        1 (1%)                                                                       
      Lumen, Hemorrhage                                2 (3%)                                 3 (4%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
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                             ----------              END OF REPORT             ----------                                           
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