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TDMS Study 05094-03 Pathology Tables

NTP Experiment-Test: 05094-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/03/96
Route: DOSED FEED                                                                                                 Time: 15:03:21




       Facility:  Southern Research Institute

       Chemical CAS #:  85-68-7

       Lock Date:  11/25/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05094-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 15:03:21  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     2.4%                                                                
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                         110          110                                                               

  Scheduled Sacrifice                                 10           10                                                               
  Early Deaths                                                                                                                      
    Dead                                               4            1                                                               
    Moribund                                          11           10                                                               
    Moribund Sacrifice                                34           38                                                               
    Natural Death                                      6            1                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           11                                                               

  Animals Examined Microscopically                   110          110                                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (109)        (109)                                                            
   Intestine Large, Cecum                             (110)        (110)                                                            
   Intestine Small, Duodenum                          (109)        (110)                                                            
   Intestine Small, Jejunum                           (110)        (110)                                                            
      Leiomyosarcoma                                   1 (1%)       1 (1%)                                                          
   Intestine Small, Ileum                             (110)        (110)                                                            
   Liver                                              (110)        (110)                                                            
      Hepatocellular Carcinoma                                      3 (3%)                                                          
      Hepatocellular Adenoma                           2 (2%)       4 (4%)                                                          
   Mesentery                                          (6)          (5)                                                              
      Lipoma                                                        1 (20%)                                                         
   Pancreas                                           (107)        (110)                                                            
      Acinus, Adenoma                                               1 (1%)                                                          
   Salivary Glands                                    (109)        (110)                                                            
   Stomach, Forestomach                               (107)        (110)                                                            
   Stomach, Glandular                                 (108)        (110)                                                            
   Tongue                                             (1)                                                                           
      Squamous Cell Papilloma                          1 (100%)                                                                     
   Tooth                                                           (4)                                                              
      Odontoma                                                      1 (25%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (110)        (110)                                                            
      Schwannoma Malignant                                          1 (1%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   2                                                               
NTP Experiment-Test: 05094-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 15:03:21  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     2.4%                                                                
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (110)        (110)                                                            
      Carcinoma                                        1 (1%)                                                                       
   Adrenal Medulla                                    (108)        (110)                                                            
      Pheochromocytoma Malignant                       1 (1%)                                                                       
      Pheochromocytoma Complex                         1 (1%)                                                                       
      Pheochromocytoma Benign                          3 (3%)       5 (5%)                                                          
   Islets, Pancreatic                                 (107)        (110)                                                            
      Adenoma                                          1 (1%)       1 (1%)                                                          
      Carcinoma                                        1 (1%)                                                                       
   Pituitary Gland                                    (110)        (109)                                                            
      Pars Distalis, Adenoma                          39 (35%)     22 (20%)                                                         
      Pars Distalis, Adenoma, Multiple                 2 (2%)                                                                       
      Pars Distalis, Carcinoma                         1 (1%)                                                                       
   Thyroid Gland                                      (109)        (110)                                                            
      C-Cell, Adenoma                                  6 (6%)       7 (6%)                                                          
      C-Cell, Carcinoma                                1 (1%)                                                                       
      Follicular Cell, Adenoma                         1 (1%)                                                                       
      Follicular Cell, Carcinoma                                    1 (1%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)                                                                           
      Sarcoma                                          1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (110)        (109)                                                            
      Adenoma                                          9 (8%)       5 (5%)                                                          
      Carcinoma                                        5 (5%)                                                                       
   Ovary                                              (110)        (110)                                                            
      Granulosa Cell Tumor Benign                      1 (1%)                                                                       
   Uterus                                             (110)        (110)                                                            
      Adenoma                                          1 (1%)                                                                       
      Polyp Stromal                                    3 (3%)       9 (8%)                                                          
      Polyp Stromal, Multiple                          1 (1%)                                                                       
      Sarcoma Stromal                                  1 (1%)                                                                       
   Vagina                                             (2)          (2)                                                              
      Squamous Cell Papilloma                          1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   3                                                               
NTP Experiment-Test: 05094-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 15:03:21  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     2.4%                                                                
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (110)        (110)                                                            
   Lymph Node                                         (32)         (27)                                                             
   Lymph Node, Mandibular                             (109)        (110)                                                            
   Lymph Node, Mesenteric                             (110)        (110)                                                            
   Spleen                                             (110)        (110)                                                            
   Thymus                                             (109)        (106)                                                            
      Thymoma Benign                                   1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (109)        (109)                                                            
      Carcinoma                                        5 (5%)       1 (1%)                                                          
      Fibroadenoma                                    28 (26%)      7 (6%)                                                          
      Fibroadenoma, Multiple                           5 (5%)                                                                       
   Skin                                               (110)        (109)                                                            
      Keratoacanthoma                                  3 (3%)       1 (1%)                                                          
      Squamous Cell Papilloma                          2 (2%)                                                                       
      Sebaceous Gland, Basal Cell Adenoma              1 (1%)                                                                       
      Subcutaneous Tissue, Fibroma                     4 (4%)                                                                       
      Subcutaneous Tissue, Fibroma, Multiple           1 (1%)                                                                       
      Subcutaneous Tissue, Melanoma Malignant          1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (110)        (110)                                                            
      Osteosarcoma                                     1 (1%)                                                                       
   Skeletal Muscle                                                 (1)                                                              
      Rhabdomyosarcoma                                              1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (110)        (109)                                                            
      Astrocytoma Malignant                            1 (1%)       1 (1%)                                                          
      Carcinoma, Metastatic, Pituitary Gland           1 (1%)                                                                       
      Carcinoma, Metastatic, Zymbal's Gland                         1 (1%)                                                          
      Ependymoma Malignant                             1 (1%)                                                                       
      Glioma Malignant                                 1 (1%)                                                                       
      Oligodendroglioma Malignant                      1 (1%)       1 (1%)                                                          
   Spinal Cord                                        (3)          (1)                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   4                                                               
NTP Experiment-Test: 05094-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 15:03:21  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     2.4%                                                                
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (110)        (110)                                                            
      Alveolar/Bronchiolar Adenoma                     1 (1%)       1 (1%)                                                          
      Alveolar/Bronchiolar Carcinoma                   1 (1%)                                                                       
      Carcinoma, Metastatic, Zymbal's Gland                         1 (1%)                                                          
      Sarcoma, Metastatic, Tissue NOS                  1 (1%)                                                                       
   Nose                                               (110)        (110)                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                     (2)          (2)                                                              
      Carcinoma                                        2 (100%)     2 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (110)        (110)                                                            
   Urinary Bladder                                    (109)        (110)                                                            
      Mast Cell Tumor Benign                           1 (1%)                                                                       
      Transitional Epithelium, Carcinoma                            4 (4%)                                                          
      Transitional Epithelium, Papilloma               1 (1%)       4 (4%)                                                          
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(110)       *(110)                                                            
      Leukemia Mononuclear                            45 (41%)     58 (53%)                                                         
      Mesothelioma NOS                                              1 (1%)                                                          
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page   5                                                               
NTP Experiment-Test: 05094-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 15:03:21  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     2.4%                                                                
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            94          78                                                               
     Total Primary Neoplasms                          192         144                                                               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 74          49                                                               
     Total Benign Neoplasms                           119          69                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              63          62                                                               
     Total Malignant Neoplasms                         73          74                                                               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           1                                                               
     Total Metastatic Neoplasm                          2           2                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                              1                                                               
     Total Uncertain Neoplasms                                      2                                                               
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page   6                                                               
NTP Experiment-Test: 05094-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 15:03:21  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     1.2%                                                                
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                         110          110                                                               

  Scheduled Sacrifice                                 10           10                                                               
  Early Deaths                                                                                                                      
    Moribund                                          14           17                                                               
    Accidently Killed                                  1                                                                            
    Dead                                               1            2                                                               
    Moribund Sacrifice                                37           29                                                               
    Natural Death                                      3            8                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           13                                                               

  Animals Examined Microscopically                   110          110                                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (108)        (106)                                                            
   Intestine Large, Cecum                             (108)        (109)                                                            
   Intestine Small, Duodenum                          (110)        (109)                                                            
   Intestine Small, Jejunum                           (109)        (108)                                                            
      Carcinoma                                        2 (2%)                                                                       
   Intestine Small, Ileum                             (109)        (108)                                                            
      Sarcoma                                                       1 (1%)                                                          
   Liver                                              (110)        (109)                                                            
      Hepatocellular Carcinoma                         2 (2%)                                                                       
      Hepatocellular Adenoma                           2 (2%)                                                                       
      Hepatocellular Adenoma, Multiple                              1 (1%)                                                          
      Histiocytic Sarcoma                              1 (1%)                                                                       
   Mesentery                                          (22)         (19)                                                             
      Fibrous Histiocytoma                                          1 (5%)                                                          
      Sarcoma                                          1 (5%)                                                                       
      Schwannoma Malignant                                          1 (5%)                                                          
   Oral Mucosa                                        (3)          (1)                                                              
      Squamous Cell Carcinoma                          2 (67%)                                                                      
      Squamous Cell Papilloma                          1 (33%)      1 (100%)                                                        
   Pancreas                                           (110)        (109)                                                            
      Sarcoma, Metastatic, Mesentery                   1 (1%)                                                                       
      Acinar Cell, Adenoma                                          1 (1%)                                                          
      Acinus, Adenoma                                               1 (1%)                                                          
      Acinus, Adenoma, Multiple                                     1 (1%)                                                          
   Salivary Glands                                    (110)        (109)                                                            
      Fibrous Histiocytoma, Metastatic, Skin                        1 (1%)                                                          
      Schwannoma Malignant                                          1 (1%)                                                          
   Stomach, Forestomach                               (110)        (110)                                                            

                                                             Page   7                                                               
NTP Experiment-Test: 05094-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 15:03:21  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     1.2%                                                                
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
      Leiomyosarcoma                                   1 (1%)                                                                       
      Squamous Cell Papilloma                          5 (5%)       1 (1%)                                                          
   Stomach, Glandular                                 (110)        (109)                                                            
   Tongue                                             (2)          (1)                                                              
      Squamous Cell Carcinoma                          1 (50%)                                                                      
      Squamous Cell Papilloma                                       1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (110)        (110)                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (110)        (110)                                                            
      Adenoma                                          1 (1%)                                                                       
   Adrenal Medulla                                    (110)        (110)                                                            
      Pheochromocytoma Malignant                       1 (1%)       2 (2%)                                                          
      Pheochromocytoma Benign                          9 (8%)      10 (9%)                                                          
      Pheochromocytoma Benign, Multiple                1 (1%)                                                                       
      Bilateral, Pheochromocytoma Benign               2 (2%)                                                                       
   Islets, Pancreatic                                 (110)        (109)                                                            
      Adenoma                                          7 (6%)       6 (6%)                                                          
      Carcinoma                                        3 (3%)       3 (3%)                                                          
   Pituitary Gland                                    (106)        (105)                                                            
      Pars Distalis, Adenoma                          11 (10%)     11 (10%)                                                         
      Pars Distalis, Adenoma, Multiple                              2 (2%)                                                          
   Thyroid Gland                                      (110)        (110)                                                            
      C-Cell, Adenoma                                  8 (7%)       8 (7%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                         (4)          (3)                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (110)        (110)                                                            
   Preputial Gland                                    (110)        (110)                                                            
      Adenoma                                          1 (1%)       3 (3%)                                                          
      Carcinoma                                        1 (1%)                                                                       
   Prostate                                           (109)        (110)                                                            
      Adenoma                                          1 (1%)                                                                       
      Carcinoma                                                     1 (1%)                                                          
   Seminal Vesicle                                    (110)        (108)                                                            

                                                             Page   8                                                               
NTP Experiment-Test: 05094-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 15:03:21  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     1.2%                                                                
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
   Testes                                             (110)        (110)                                                            
      Bilateral, Interstitial Cell, Adenoma           80 (73%)     81 (74%)                                                         
      Interstitial Cell, Adenoma                      20 (18%)     18 (16%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (110)        (110)                                                            
      Histiocytic Sarcoma                              1 (1%)                                                                       
   Lymph Node                                         (42)         (42)                                                             
      Mediastinal, Fibrous Histiocytoma                             1 (2%)                                                          
      Mediastinal, Histiocytic Sarcoma                 1 (2%)                                                                       
   Lymph Node, Mandibular                             (107)        (106)                                                            
      Histiocytic Sarcoma                              1 (1%)                                                                       
   Lymph Node, Mesenteric                             (110)        (109)                                                            
      Histiocytic Sarcoma                              1 (1%)                                                                       
   Spleen                                             (110)        (109)                                                            
      Fibroma                                                       1 (1%)                                                          
      Sarcoma                                          1 (1%)                                                                       
   Thymus                                             (102)        (103)                                                            
      Thymoma Benign                                                2 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (104)        (108)                                                            
      Carcinoma                                                     1 (1%)                                                          
      Fibroadenoma                                     5 (5%)       3 (3%)                                                          
   Skin                                               (109)        (108)                                                            
      Keratoacanthoma                                  4 (4%)       4 (4%)                                                          
      Trichoepithelioma                                1 (1%)                                                                       
      Subcutaneous Tissue, Fibroma                     5 (5%)       3 (3%)                                                          
      Subcutaneous Tissue, Fibrosarcoma                1 (1%)                                                                       
      Subcutaneous Tissue, Fibrous Histiocytoma                     1 (1%)                                                          
      Subcutaneous Tissue, Lipoma                                   1 (1%)                                                          
      Subcutaneous Tissue, Melanoma Benign                          2 (2%)                                                          
      Subcutaneous Tissue, Melanoma Malignant          1 (1%)       1 (1%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                                 (2)                                                              
      Fibrous Histiocytoma                                          1 (50%)                                                         
      Fibrous Histiocytoma, Metastatic, Skin                        1 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   9                                                               
NTP Experiment-Test: 05094-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 15:03:21  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     1.2%                                                                
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (110)        (109)                                                            
      Astrocytoma Malignant                            2 (2%)       1 (1%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (110)        (110)                                                            
      Alveolar/Bronchiolar Adenoma                     1 (1%)       2 (2%)                                                          
      Alveolar/Bronchiolar Carcinoma                   1 (1%)       1 (1%)                                                          
      Sarcoma, Metastatic, Mesentery                   1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)          (1)                                                              
      Schwannoma Malignant                                          1 (100%)                                                        
   Zymbal's Gland                                     (2)          (1)                                                              
      Carcinoma                                        2 (100%)     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (110)        (109)                                                            
   Urinary Bladder                                    (110)        (110)                                                            
      Transitional Epithelium, Carcinoma                            1 (1%)                                                          
      Transitional Epithelium, Papilloma                            2 (2%)                                                          
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(110)       *(110)                                                            
      Histiocytic Sarcoma                              1 (1%)                                                                       
      Leukemia Mononuclear                            60 (55%)     64 (58%)                                                         
      Mesothelioma Malignant                           4 (4%)       3 (3%)                                                          
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page  10                                                               
NTP Experiment-Test: 05094-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 15:03:21  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     1.2%                                                                
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)           107         104                                                               
     Total Primary Neoplasms                          252         253                                                               
                                                                                                                                    
   Total Animals with Benign Neoplasms                103         102                                                               
     Total Benign Neoplasms                           165         166                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              75          75                                                               
     Total Malignant Neoplasms                         87          87                                                               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           1                                                               
     Total Metastatic Neoplasm                          2           2                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page  11                                                               
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