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https://ntp.niehs.nih.gov/go/3351

TDMS Study 05099-07 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                             SALICYLAZOSULFAPYRIDINE                                DATE: 04/10/95       
EXPERIMENT: 05099 TEST: 07                                                                                     TIME: 09:00:10       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-85233          ROUTE: GAVAGE                                                                      NTP C#: 61552B       
PATHOLOGIST: DR J. HEATH                                                                                       CAS: 599-79-1        
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                    STOP COMPARISON 2 YEAR CORE                                                     
                                                                                                                                    
               REASONS FOR REMOVAL:    25018 Dosing Accident                                                                        
                                       25019 Moribund Sacrifice                                                                     
                                       25020 Natural Death                                                                          
                                       25021 Terminal Sacrifice                                                                     
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE 001    0 MG/KG                                                                       
                                       INCLUDE 009    337.5   STOP                                                                  
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                             SALICYLAZOSULFAPYRIDINE                                DATE: 04/10/95       
EXPERIMENT: 05099 TEST: 07                                                                                     TIME: 09:00:10       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-85233          ROUTE: GAVAGE                                                                      NTP C#: 61552B       
PATHOLOGIST: DR J. HEATH                                                                                       CAS: 599-79-1        


                                                    RATS(FISCHER344)
                                              ----------------------------
             FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
             IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
                                                                    
                                                    ----------------
                                                    Adrenal Cortex
                                                    Adrenal Medulla
                                                    Bone Marrow
                                                    Brain
                                                    Clitoral/Preputial Gland
                                                    Epididymis
                                                    Heart
                                                    Islets, Pancreatic
                                                    Kidney
                                                    Liver
                                                    Lung
                                                    Nose
                                                    Pancreas
                                                    Parathyroid Gland
                                                    Pituitary Gland
                                                    Preputial Gland
                                                    Prostate
                                                    Salivary Glands
                                                    Spleen
                                                    Testes
                                                    Thymus
                                                    Thyroid Gland
                                                    Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                             SALICYLAZOSULFAPYRIDINE                                DATE: 04/10/95       
EXPERIMENT: 05099 TEST: 07                                                                                     TIME: 09:00:10       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-85233          ROUTE: GAVAGE                                                                      NTP C#: 61552B       
PATHOLOGIST: DR J. HEATH                                                                                       CAS: 599-79-1        


                                     SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
                                    IN THE ANALYSIS OF THE STUDY OF SALICYLAZOSULFAPYRIDINE
              ====================================================================================================
                                                           MALE RATS
                                                          -------------
                  ORGAN                               MORPHOLOGY
                 -------                             ------------
              Adrenal Medulla               Pheochromocytoma Benign
                                            Pheochromocytoma: Benign, Complex, Malignant, NOS
              Pancreas                      Adenoma
                                            Carcinoma or Adenoma
              Testes                        Adenoma
              All Organs                    Benign Tumors
              ====================================================================================================
         DATE: 04/10/95                     EXPERIMENT: 05099 TEST: 07                                                 PAGE   1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- SALICYLAZOSULFAPYRIDINE
                       TERMINAL SACRIFICE AT 105 WEEKS
|==============================================================================|
|DOSE                   |          0 MG/KG             337.5                   |
|                       |                              STOP                    |
|==============================================================================|
|                                                                              |
|Adrenal Cortex                                                                |
|     Adenoma                                                                  |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |                                                      |
|-----------            |                                                      |
|OVERALL (a)            |         0/50 (0%)           2/50 (4%)                |
|ADJUSTED (b)           |          0.0%                6.7%                    |
|TERMINAL (d)           |         0/35 (0%)           2/30 (7%)                |
|FIRST INCIDENCE (DAYS) |          ---                 729 (T)                 |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |                             P=0.205                  |
|INCIDENTAL TUMOR       |                             P=0.205                  |
|LOGISTIC REGRESSION    |                             P=0.205                  |
|COCHRAN-ARMITAGE       |                                                      |
|FISHER EXACT           |                             P=0.247                  |
|==============================================================================|
|                                                                              |
|Adrenal Medulla                                                               |
|     Pheochromocytoma Benign                                                  |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |                                                      |
|-----------            |                                                      |
|OVERALL (a)            |        15/50 (30%)          4/50 (8%)                |
|ADJUSTED (b)           |         38.2%               13.3%                    |
|TERMINAL (d)           |        11/35 (31%)          4/30 (13%)               |
|FIRST INCIDENCE (DAYS) |          653                 729 (T)                 |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |                             P=0.016N*                |
|INCIDENTAL TUMOR       |                             P=0.016N*                |
|LOGISTIC REGRESSION    |                             P=0.015N*                |
|COCHRAN-ARMITAGE       |                                                      |
|FISHER EXACT           |                             P=0.005N**               |
|==============================================================================|
         DATE: 04/10/95                     EXPERIMENT: 05099 TEST: 07                                                 PAGE   2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- SALICYLAZOSULFAPYRIDINE
                       TERMINAL SACRIFICE AT 105 WEEKS
|==============================================================================|
|DOSE                   |          0 MG/KG             337.5                   |
|                       |                              STOP                    |
|==============================================================================|
|                                                                              |
|Adrenal Medulla                                                               |
|     Pheochromocytoma Malignant                                               |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |                                                      |
|-----------            |                                                      |
|OVERALL (a)            |         0/50 (0%)           2/50 (4%)                |
|ADJUSTED (b)           |          0.0%                6.5%                    |
|TERMINAL (d)           |         0/35 (0%)           1/30 (3%)                |
|FIRST INCIDENCE (DAYS) |          ---                 704                     |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |                             P=0.199                  |
|INCIDENTAL TUMOR       |                             P=0.188                  |
|LOGISTIC REGRESSION    |                             P=0.199                  |
|COCHRAN-ARMITAGE       |                                                      |
|FISHER EXACT           |                             P=0.247                  |
|==============================================================================|
|                                                                              |
|Adrenal Medulla                                                               |
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                        |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |                                                      |
|-----------            |                                                      |
|OVERALL (a)            |        16/50 (32%)          6/50 (12%)               |
|ADJUSTED (b)           |         39.8%               19.4%                    |
|TERMINAL (d)           |        11/35 (31%)          5/30 (17%)               |
|FIRST INCIDENCE (DAYS) |          653                 704                     |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |                             P=0.048N*                |
|INCIDENTAL TUMOR       |                             P=0.042N*                |
|LOGISTIC REGRESSION    |                             P=0.039N*                |
|COCHRAN-ARMITAGE       |                                                      |
|FISHER EXACT           |                             P=0.014N*                |
|==============================================================================|
         DATE: 04/10/95                     EXPERIMENT: 05099 TEST: 07                                                 PAGE   3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- SALICYLAZOSULFAPYRIDINE
                       TERMINAL SACRIFICE AT 105 WEEKS
|==============================================================================|
|DOSE                   |          0 MG/KG             337.5                   |
|                       |                              STOP                    |
|==============================================================================|
|                                                                              |
|Clitoral/Preputial Gland                                                      |
|     Adenoma                                                                  |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |                                                      |
|-----------            |                                                      |
|OVERALL (a)            |         1/50 (2%)           5/50 (10%)               |
|ADJUSTED (b)           |          2.5%               16.7%                    |
|TERMINAL (d)           |         0/35 (0%)           5/30 (17%)               |
|FIRST INCIDENCE (DAYS) |          684                 729 (T)                 |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |                             P=0.072                  |
|INCIDENTAL TUMOR       |                             P=0.067                  |
|LOGISTIC REGRESSION    |                             P=0.064                  |
|COCHRAN-ARMITAGE       |                                                      |
|FISHER EXACT           |                             P=0.102                  |
|==============================================================================|
|                                                                              |
|Clitoral/Preputial Gland                                                      |
|     Carcinoma                                                                |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |                                                      |
|-----------            |                                                      |
|OVERALL (a)            |         2/50 (4%)           2/50 (4%)                |
|ADJUSTED (b)           |          5.3%                5.5%                    |
|TERMINAL (d)           |         1/35 (3%)           1/30 (3%)                |
|FIRST INCIDENCE (DAYS) |          708                 383                     |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |                             P=0.633                  |
|INCIDENTAL TUMOR       |                             P=0.672                  |
|LOGISTIC REGRESSION    |                             P=0.681N                 |
|COCHRAN-ARMITAGE       |                                                      |
|FISHER EXACT           |                             P=0.691N                 |
|==============================================================================|
         DATE: 04/10/95                     EXPERIMENT: 05099 TEST: 07                                                 PAGE   4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- SALICYLAZOSULFAPYRIDINE
                       TERMINAL SACRIFICE AT 105 WEEKS
|==============================================================================|
|DOSE                   |          0 MG/KG             337.5                   |
|                       |                              STOP                    |
|==============================================================================|
|                                                                              |
|Clitoral/Preputial Gland                                                      |
|     Carcinoma or Adenoma                                                     |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |                                                      |
|-----------            |                                                      |
|OVERALL (a)            |         3/50 (6%)           7/50 (14%)               |
|ADJUSTED (b)           |          7.7%               21.8%                    |
|TERMINAL (d)           |         1/35 (3%)           6/30 (20%)               |
|FIRST INCIDENCE (DAYS) |          684                 383                     |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |                             P=0.106                  |
|INCIDENTAL TUMOR       |                             P=0.111                  |
|LOGISTIC REGRESSION    |                             P=0.122                  |
|COCHRAN-ARMITAGE       |                                                      |
|FISHER EXACT           |                             P=0.159                  |
|==============================================================================|
|                                                                              |
|Islets, Pancreatic                                                            |
|     Adenoma                                                                  |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |                                                      |
|-----------            |                                                      |
|OVERALL (a)            |         2/50 (4%)           0/49 (0%)                |
|ADJUSTED (b)           |          5.3%                0.0%                    |
|TERMINAL (d)           |         1/35 (3%)           0/30 (0%)                |
|FIRST INCIDENCE (DAYS) |          684                 ---                     |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |                             P=0.279N                 |
|INCIDENTAL TUMOR       |                             P=0.295N                 |
|LOGISTIC REGRESSION    |                             P=0.269N                 |
|COCHRAN-ARMITAGE       |                                                      |
|FISHER EXACT           |                             P=0.253N                 |
|==============================================================================|
         DATE: 04/10/95                     EXPERIMENT: 05099 TEST: 07                                                 PAGE   5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- SALICYLAZOSULFAPYRIDINE
                       TERMINAL SACRIFICE AT 105 WEEKS
|==============================================================================|
|DOSE                   |          0 MG/KG             337.5                   |
|                       |                              STOP                    |
|==============================================================================|
|                                                                              |
|Islets, Pancreatic                                                            |
|     Carcinoma or Adenoma                                                     |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |                                                      |
|-----------            |                                                      |
|OVERALL (a)            |         3/50 (6%)           0/49 (0%)                |
|ADJUSTED (b)           |          8.1%                0.0%                    |
|TERMINAL (d)           |         2/35 (6%)           0/30 (0%)                |
|FIRST INCIDENCE (DAYS) |          684                 ---                     |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |                             P=0.154N                 |
|INCIDENTAL TUMOR       |                             P=0.163N                 |
|LOGISTIC REGRESSION    |                             P=0.150N                 |
|COCHRAN-ARMITAGE       |                                                      |
|FISHER EXACT           |                             P=0.125N                 |
|==============================================================================|
|                                                                              |
|Liver                                                                         |
|     Hepatocellular Adenoma                                                   |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |                                                      |
|-----------            |                                                      |
|OVERALL (a)            |         2/50 (4%)           0/50 (0%)                |
|ADJUSTED (b)           |          5.6%                0.0%                    |
|TERMINAL (d)           |         1/35 (3%)           0/30 (0%)                |
|FIRST INCIDENCE (DAYS) |          726                 ---                     |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |                             P=0.277N                 |
|INCIDENTAL TUMOR       |                             P=0.295N                 |
|LOGISTIC REGRESSION    |                             P=0.283N                 |
|COCHRAN-ARMITAGE       |                                                      |
|FISHER EXACT           |                             P=0.247N                 |
|==============================================================================|
         DATE: 04/10/95                     EXPERIMENT: 05099 TEST: 07                                                 PAGE   6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- SALICYLAZOSULFAPYRIDINE
                       TERMINAL SACRIFICE AT 105 WEEKS
|==============================================================================|
|DOSE                   |          0 MG/KG             337.5                   |
|                       |                              STOP                    |
|==============================================================================|
|                                                                              |
|Lung                                                                          |
|     Alveolar/Bronchiolar Adenoma                                             |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |                                                      |
|-----------            |                                                      |
|OVERALL (a)            |         2/50 (4%)           0/50 (0%)                |
|ADJUSTED (b)           |          5.7%                0.0%                    |
|TERMINAL (d)           |         2/35 (6%)           0/30 (0%)                |
|FIRST INCIDENCE (DAYS) |          729 (T)             ---                     |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |                             P=0.273N                 |
|INCIDENTAL TUMOR       |                             P=0.273N                 |
|LOGISTIC REGRESSION    |                             P=0.273N                 |
|COCHRAN-ARMITAGE       |                                                      |
|FISHER EXACT           |                             P=0.247N                 |
|==============================================================================|
|                                                                              |
|Lung                                                                          |
|     Alveolar/Bronchiolar Carcinoma                                           |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |                                                      |
|-----------            |                                                      |
|OVERALL (a)            |         0/50 (0%)           2/50 (4%)                |
|ADJUSTED (b)           |          0.0%                6.7%                    |
|TERMINAL (d)           |         0/35 (0%)           2/30 (7%)                |
|FIRST INCIDENCE (DAYS) |          ---                 729 (T)                 |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |                             P=0.205                  |
|INCIDENTAL TUMOR       |                             P=0.205                  |
|LOGISTIC REGRESSION    |                             P=0.205                  |
|COCHRAN-ARMITAGE       |                                                      |
|FISHER EXACT           |                             P=0.247                  |
|==============================================================================|
         DATE: 04/10/95                     EXPERIMENT: 05099 TEST: 07                                                 PAGE   7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- SALICYLAZOSULFAPYRIDINE
                       TERMINAL SACRIFICE AT 105 WEEKS
|==============================================================================|
|DOSE                   |          0 MG/KG             337.5                   |
|                       |                              STOP                    |
|==============================================================================|
|                                                                              |
|Lung                                                                          |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma           |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |                                                      |
|-----------            |                                                      |
|OVERALL (a)            |         2/50 (4%)           2/50 (4%)                |
|ADJUSTED (b)           |          5.7%                6.7%                    |
|TERMINAL (d)           |         2/35 (6%)           2/30 (7%)                |
|FIRST INCIDENCE (DAYS) |          729 (T)             729 (T)                 |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |                             P=0.639                  |
|INCIDENTAL TUMOR       |                             P=0.639                  |
|LOGISTIC REGRESSION    |                             P=0.639                  |
|COCHRAN-ARMITAGE       |                                                      |
|FISHER EXACT           |                             P=0.691N                 |
|==============================================================================|
|                                                                              |
|Mammary Gland                                                                 |
|     Fibroadenoma                                                             |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |           #                   #                      |
|-----------            |                                                      |
|OVERALL (a)            |         3/50 (6%)           4/50 (8%)                |
|ADJUSTED (b)           |          8.6%               12.1%                    |
|TERMINAL (d)           |         3/35 (9%)           2/30 (7%)                |
|FIRST INCIDENCE (DAYS) |          729 (T)             644                     |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |                             P=0.414                  |
|INCIDENTAL TUMOR       |                             P=0.437                  |
|LOGISTIC REGRESSION    |                             P=0.412                  |
|COCHRAN-ARMITAGE       |                                                      |
|FISHER EXACT           |                             P=0.500                  |
|==============================================================================|
         DATE: 04/10/95                     EXPERIMENT: 05099 TEST: 07                                                 PAGE   8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- SALICYLAZOSULFAPYRIDINE
                       TERMINAL SACRIFICE AT 105 WEEKS
|==============================================================================|
|DOSE                   |          0 MG/KG             337.5                   |
|                       |                              STOP                    |
|==============================================================================|
|                                                                              |
|Pancreas                                                                      |
|     Adenoma                                                                  |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |                                                      |
|-----------            |                                                      |
|OVERALL (a)            |        12/50 (24%)          4/48 (8%)                |
|ADJUSTED (b)           |         31.4%               12.8%                    |
|TERMINAL (d)           |         9/35 (26%)          3/30 (10%)               |
|FIRST INCIDENCE (DAYS) |          684                 696                     |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |                             P=0.064N                 |
|INCIDENTAL TUMOR       |                             P=0.065N                 |
|LOGISTIC REGRESSION    |                             P=0.062N                 |
|COCHRAN-ARMITAGE       |                                                      |
|FISHER EXACT           |                             P=0.033N*                |
|==============================================================================|
|                                                                              |
|Pancreas                                                                      |
|     Carcinoma or Adenoma                                                     |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |                                                      |
|-----------            |                                                      |
|OVERALL (a)            |        13/50 (26%)          4/48 (8%)                |
|ADJUSTED (b)           |         34.1%               12.8%                    |
|TERMINAL (d)           |        10/35 (29%)          3/30 (10%)               |
|FIRST INCIDENCE (DAYS) |          684                 696                     |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |                             P=0.041N*                |
|INCIDENTAL TUMOR       |                             P=0.041N*                |
|LOGISTIC REGRESSION    |                             P=0.040N*                |
|COCHRAN-ARMITAGE       |                                                      |
|FISHER EXACT           |                             P=0.019N*                |
|==============================================================================|
         DATE: 04/10/95                     EXPERIMENT: 05099 TEST: 07                                                 PAGE   9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- SALICYLAZOSULFAPYRIDINE
                       TERMINAL SACRIFICE AT 105 WEEKS
|==============================================================================|
|DOSE                   |          0 MG/KG             337.5                   |
|                       |                              STOP                    |
|==============================================================================|
|                                                                              |
|Pituitary Gland: Pars Distalis or Unspecified Site                            |
|     Adenoma                                                                  |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |                                                      |
|-----------            |                                                      |
|OVERALL (a)            |        14/50 (28%)         18/49 (37%)               |
|ADJUSTED (b)           |         34.3%               46.4%                    |
|TERMINAL (d)           |         9/35 (26%)         10/30 (33%)               |
|FIRST INCIDENCE (DAYS) |          473                 423                     |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |                             P=0.140                  |
|INCIDENTAL TUMOR       |                             P=0.160                  |
|LOGISTIC REGRESSION    |                             P=0.177                  |
|COCHRAN-ARMITAGE       |                                                      |
|FISHER EXACT           |                             P=0.238                  |
|==============================================================================|
|                                                                              |
|Skin                                                                          |
|     Basal Cell Adenoma                                                       |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |           #                   #                      |
|-----------            |                                                      |
|OVERALL (a)            |         2/50 (4%)           0/50 (0%)                |
|ADJUSTED (b)           |          5.4%                0.0%                    |
|TERMINAL (d)           |         1/35 (3%)           0/30 (0%)                |
|FIRST INCIDENCE (DAYS) |          717                 ---                     |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |                             P=0.284N                 |
|INCIDENTAL TUMOR       |                             P=0.295N                 |
|LOGISTIC REGRESSION    |                             P=0.280N                 |
|COCHRAN-ARMITAGE       |                                                      |
|FISHER EXACT           |                             P=0.247N                 |
|==============================================================================|
         DATE: 04/10/95                     EXPERIMENT: 05099 TEST: 07                                                 PAGE  10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- SALICYLAZOSULFAPYRIDINE
                       TERMINAL SACRIFICE AT 105 WEEKS
|==============================================================================|
|DOSE                   |          0 MG/KG             337.5                   |
|                       |                              STOP                    |
|==============================================================================|
|                                                                              |
|Skin                                                                          |
|     Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor (M or B), Basal    |
|     Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoep|thelioma
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |           #                   #                      |
|-----------            |                                                      |
|OVERALL (a)            |         6/50 (12%)          4/50 (8%)                |
|ADJUSTED (b)           |         16.5%               13.3%                    |
|TERMINAL (d)           |         5/35 (14%)          4/30 (13%)               |
|FIRST INCIDENCE (DAYS) |          717                 729 (T)                 |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |                             P=0.474N                 |
|INCIDENTAL TUMOR       |                             P=0.481N                 |
|LOGISTIC REGRESSION    |                             P=0.502N                 |
|COCHRAN-ARMITAGE       |                                                      |
|FISHER EXACT           |                             P=0.370N                 |
|==============================================================================|
|                                                                              |
|Skin                                                                          |
|     Fibroma                                                                  |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |           #                   #                      |
|-----------            |                                                      |
|OVERALL (a)            |         2/50 (4%)           6/50 (12%)               |
|ADJUSTED (b)           |          5.7%               19.3%                    |
|TERMINAL (d)           |         2/35 (6%)           5/30 (17%)               |
|FIRST INCIDENCE (DAYS) |          729 (T)             696                     |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |                             P=0.089                  |
|INCIDENTAL TUMOR       |                             P=0.085                  |
|LOGISTIC REGRESSION    |                             P=0.077                  |
|COCHRAN-ARMITAGE       |                                                      |
|FISHER EXACT           |                             P=0.134                  |
|==============================================================================|
         DATE: 04/10/95                     EXPERIMENT: 05099 TEST: 07                                                 PAGE  11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- SALICYLAZOSULFAPYRIDINE
                       TERMINAL SACRIFICE AT 105 WEEKS
|==============================================================================|
|DOSE                   |          0 MG/KG             337.5                   |
|                       |                              STOP                    |
|==============================================================================|
|                                                                              |
|Skin                                                                          |
|     Keratoacanthoma                                                          |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |           #                   #                      |
|-----------            |                                                      |
|OVERALL (a)            |         3/50 (6%)           3/50 (6%)                |
|ADJUSTED (b)           |          8.6%               10.0%                    |
|TERMINAL (d)           |         3/35 (9%)           3/30 (10%)               |
|FIRST INCIDENCE (DAYS) |          729 (T)             729 (T)                 |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |                             P=0.591                  |
|INCIDENTAL TUMOR       |                             P=0.591                  |
|LOGISTIC REGRESSION    |                             P=0.591                  |
|COCHRAN-ARMITAGE       |                                                      |
|FISHER EXACT           |                             P=0.661N                 |
|==============================================================================|
|                                                                              |
|Skin                                                                          |
|     Neurofibrosarcoma, Neurofibroma, or Schwannoma (benign, malignant or NOS)|
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |           #                   #                      |
|-----------            |                                                      |
|OVERALL (a)            |         0/50 (0%)           3/50 (6%)                |
|ADJUSTED (b)           |          0.0%                7.9%                    |
|TERMINAL (d)           |         0/35 (0%)           1/30 (3%)                |
|FIRST INCIDENCE (DAYS) |          ---                 423                     |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |                             P=0.103                  |
|INCIDENTAL TUMOR       |                             P=0.154                  |
|LOGISTIC REGRESSION    |                             P=0.156                  |
|COCHRAN-ARMITAGE       |                                                      |
|FISHER EXACT           |                             P=0.121                  |
|==============================================================================|
         DATE: 04/10/95                     EXPERIMENT: 05099 TEST: 07                                                 PAGE  12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- SALICYLAZOSULFAPYRIDINE
                       TERMINAL SACRIFICE AT 105 WEEKS
|==============================================================================|
|DOSE                   |          0 MG/KG             337.5                   |
|                       |                              STOP                    |
|==============================================================================|
|                                                                              |
|Skin                                                                          |
|     Schwannoma Malignant                                                     |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |           #                   #                      |
|-----------            |                                                      |
|OVERALL (a)            |         0/50 (0%)           2/50 (4%)                |
|ADJUSTED (b)           |          0.0%                5.8%                    |
|TERMINAL (d)           |         0/35 (0%)           1/30 (3%)                |
|FIRST INCIDENCE (DAYS) |          ---                 542                     |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |                             P=0.210                  |
|INCIDENTAL TUMOR       |                             P=0.265                  |
|LOGISTIC REGRESSION    |                             P=0.244                  |
|COCHRAN-ARMITAGE       |                                                      |
|FISHER EXACT           |                             P=0.247                  |
|==============================================================================|
|                                                                              |
|Skin                                                                          |
|     Squamous Cell Papilloma, Papilloma, Squamous Cell Carcinoma or Keratoacan|homa
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |           #                   #                      |
|-----------            |                                                      |
|OVERALL (a)            |         4/50 (8%)           4/50 (8%)                |
|ADJUSTED (b)           |         11.4%               13.3%                    |
|TERMINAL (d)           |         4/35 (11%)          4/30 (13%)               |
|FIRST INCIDENCE (DAYS) |          729 (T)             729 (T)                 |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |                             P=0.557                  |
|INCIDENTAL TUMOR       |                             P=0.557                  |
|LOGISTIC REGRESSION    |                             P=0.557                  |
|COCHRAN-ARMITAGE       |                                                      |
|FISHER EXACT           |                             P=0.643N                 |
|==============================================================================|
         DATE: 04/10/95                     EXPERIMENT: 05099 TEST: 07                                                 PAGE  13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- SALICYLAZOSULFAPYRIDINE
                       TERMINAL SACRIFICE AT 105 WEEKS
|==============================================================================|
|DOSE                   |          0 MG/KG             337.5                   |
|                       |                              STOP                    |
|==============================================================================|
|                                                                              |
|Skin                                                                          |
|     Squamous Cell Papilloma, Papilloma, or Keratoacanthoma                   |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |           #                   #                      |
|-----------            |                                                      |
|OVERALL (a)            |         4/50 (8%)           4/50 (8%)                |
|ADJUSTED (b)           |         11.4%               13.3%                    |
|TERMINAL (d)           |         4/35 (11%)          4/30 (13%)               |
|FIRST INCIDENCE (DAYS) |          729 (T)             729 (T)                 |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |                             P=0.557                  |
|INCIDENTAL TUMOR       |                             P=0.557                  |
|LOGISTIC REGRESSION    |                             P=0.557                  |
|COCHRAN-ARMITAGE       |                                                      |
|FISHER EXACT           |                             P=0.643N                 |
|==============================================================================|
|                                                                              |
|Testes                                                                        |
|     Adenoma                                                                  |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |                                                      |
|-----------            |                                                      |
|OVERALL (a)            |        45/50 (90%)         37/50 (74%)               |
|ADJUSTED (b)           |         97.8%               97.3%                    |
|TERMINAL (d)           |        34/35 (97%)         29/30 (97%)               |
|FIRST INCIDENCE (DAYS) |          477                 423                     |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |                             P=0.466N                 |
|INCIDENTAL TUMOR       |                             P=0.238N                 |
|LOGISTIC REGRESSION    |                             P=0.308N                 |
|COCHRAN-ARMITAGE       |                                                      |
|FISHER EXACT           |                             P=0.033N*                |
|==============================================================================|
         DATE: 04/10/95                     EXPERIMENT: 05099 TEST: 07                                                 PAGE  14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- SALICYLAZOSULFAPYRIDINE
                       TERMINAL SACRIFICE AT 105 WEEKS
|==============================================================================|
|DOSE                   |          0 MG/KG             337.5                   |
|                       |                              STOP                    |
|==============================================================================|
|                                                                              |
|Thyroid Gland: C-Cell                                                         |
|     Adenoma                                                                  |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |                                                      |
|-----------            |                                                      |
|OVERALL (a)            |         3/50 (6%)           4/50 (8%)                |
|ADJUSTED (b)           |          8.6%               12.3%                    |
|TERMINAL (d)           |         3/35 (9%)           2/30 (7%)                |
|FIRST INCIDENCE (DAYS) |          729 (T)             648                     |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |                             P=0.409                  |
|INCIDENTAL TUMOR       |                             P=0.389                  |
|LOGISTIC REGRESSION    |                             P=0.410                  |
|COCHRAN-ARMITAGE       |                                                      |
|FISHER EXACT           |                             P=0.500                  |
|==============================================================================|
|                                                                              |
|Thyroid Gland: C-Cell                                                         |
|     Carcinoma                                                                |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |                                                      |
|-----------            |                                                      |
|OVERALL (a)            |         2/50 (4%)           2/50 (4%)                |
|ADJUSTED (b)           |          5.7%                6.7%                    |
|TERMINAL (d)           |         2/35 (6%)           2/30 (7%)                |
|FIRST INCIDENCE (DAYS) |          729 (T)             729 (T)                 |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |                             P=0.639                  |
|INCIDENTAL TUMOR       |                             P=0.639                  |
|LOGISTIC REGRESSION    |                             P=0.639                  |
|COCHRAN-ARMITAGE       |                                                      |
|FISHER EXACT           |                             P=0.691N                 |
|==============================================================================|
         DATE: 04/10/95                     EXPERIMENT: 05099 TEST: 07                                                 PAGE  15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- SALICYLAZOSULFAPYRIDINE
                       TERMINAL SACRIFICE AT 105 WEEKS
|==============================================================================|
|DOSE                   |          0 MG/KG             337.5                   |
|                       |                              STOP                    |
|==============================================================================|
|                                                                              |
|Thyroid Gland: C-Cell                                                         |
|     Carcinoma or Adenoma                                                     |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |                                                      |
|-----------            |                                                      |
|OVERALL (a)            |         5/50 (10%)          6/50 (12%)               |
|ADJUSTED (b)           |         14.3%               18.5%                    |
|TERMINAL (d)           |         5/35 (14%)          4/30 (13%)               |
|FIRST INCIDENCE (DAYS) |          729 (T)             648                     |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |                             P=0.387                  |
|INCIDENTAL TUMOR       |                             P=0.370                  |
|LOGISTIC REGRESSION    |                             P=0.373                  |
|COCHRAN-ARMITAGE       |                                                      |
|FISHER EXACT           |                             P=0.500                  |
|==============================================================================|
|                                                                              |
|Thyroid Gland: Follicular Cell                                                |
|     Adenoma                                                                  |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |                                                      |
|-----------            |                                                      |
|OVERALL (a)            |         4/50 (8%)           0/50 (0%)                |
|ADJUSTED (b)           |         11.4%                0.0%                    |
|TERMINAL (d)           |         4/35 (11%)          0/30 (0%)                |
|FIRST INCIDENCE (DAYS) |          729 (T)             ---                     |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |                             P=0.083N                 |
|INCIDENTAL TUMOR       |                             P=0.083N                 |
|LOGISTIC REGRESSION    |                             P=0.083N                 |
|COCHRAN-ARMITAGE       |                                                      |
|FISHER EXACT           |                             P=0.059N                 |
|==============================================================================|
         DATE: 04/10/95                     EXPERIMENT: 05099 TEST: 07                                                 PAGE  16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- SALICYLAZOSULFAPYRIDINE
                       TERMINAL SACRIFICE AT 105 WEEKS
|==============================================================================|
|DOSE                   |          0 MG/KG             337.5                   |
|                       |                              STOP                    |
|==============================================================================|
|                                                                              |
|Thyroid Gland: Follicular Cell                                                |
|     Carcinoma                                                                |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |                                                      |
|-----------            |                                                      |
|OVERALL (a)            |         1/50 (2%)           2/50 (4%)                |
|ADJUSTED (b)           |          2.9%                6.7%                    |
|TERMINAL (d)           |         1/35 (3%)           2/30 (7%)                |
|FIRST INCIDENCE (DAYS) |          729 (T)             729 (T)                 |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |                             P=0.446                  |
|INCIDENTAL TUMOR       |                             P=0.446                  |
|LOGISTIC REGRESSION    |                             P=0.446                  |
|COCHRAN-ARMITAGE       |                                                      |
|FISHER EXACT           |                             P=0.500                  |
|==============================================================================|
|                                                                              |
|Thyroid Gland: Follicular Cell                                                |
|     Carcinoma or Adenoma                                                     |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |                                                      |
|-----------            |                                                      |
|OVERALL (a)            |         5/50 (10%)          2/50 (4%)                |
|ADJUSTED (b)           |         14.3%                6.7%                    |
|TERMINAL (d)           |         5/35 (14%)          2/30 (7%)                |
|FIRST INCIDENCE (DAYS) |          729 (T)             729 (T)                 |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |                             P=0.280N                 |
|INCIDENTAL TUMOR       |                             P=0.280N                 |
|LOGISTIC REGRESSION    |                             P=0.280N                 |
|COCHRAN-ARMITAGE       |                                                      |
|FISHER EXACT           |                             P=0.218N                 |
|==============================================================================|
         DATE: 04/10/95                     EXPERIMENT: 05099 TEST: 07                                                 PAGE  17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- SALICYLAZOSULFAPYRIDINE
                       TERMINAL SACRIFICE AT 105 WEEKS
|==============================================================================|
|DOSE                   |          0 MG/KG             337.5                   |
|                       |                              STOP                    |
|==============================================================================|
|                                                                              |
|All Organs                                                                    |
|     Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated       |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |           #                   #                      |
|-----------            |                                                      |
|OVERALL (a)            |        13/50 (26%)         10/50 (20%)               |
|ADJUSTED (b)           |         32.0%               30.9%                    |
|TERMINAL (d)           |         8/35 (23%)          8/30 (27%)               |
|FIRST INCIDENCE (DAYS) |          477                 648                     |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |                             P=0.492N                 |
|INCIDENTAL TUMOR       |                             P=0.473N                 |
|LOGISTIC REGRESSION    |                             P=0.468N                 |
|COCHRAN-ARMITAGE       |                                                      |
|FISHER EXACT           |                             P=0.318N                 |
|==============================================================================|
|                                                                              |
|All Organs                                                                    |
|     Mesothelioma: Benign, Malignant, NOS                                     |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |           #                   #                      |
|-----------            |                                                      |
|OVERALL (a)            |         1/50 (2%)           2/50 (4%)                |
|ADJUSTED (b)           |          2.9%                6.7%                    |
|TERMINAL (d)           |         1/35 (3%)           2/30 (7%)                |
|FIRST INCIDENCE (DAYS) |          729 (T)             729 (T)                 |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |                             P=0.446                  |
|INCIDENTAL TUMOR       |                             P=0.446                  |
|LOGISTIC REGRESSION    |                             P=0.446                  |
|COCHRAN-ARMITAGE       |                                                      |
|FISHER EXACT           |                             P=0.500                  |
|==============================================================================|
         DATE: 04/10/95                     EXPERIMENT: 05099 TEST: 07                                                 PAGE  18
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- SALICYLAZOSULFAPYRIDINE
                       TERMINAL SACRIFICE AT 105 WEEKS
|==============================================================================|
|DOSE                   |          0 MG/KG             337.5                   |
|                       |                              STOP                    |
|==============================================================================|
|                                                                              |
|All Organs                                                                    |
|     Benign Tumors                                                            |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |           #                   #                      |
|-----------            |                                                      |
|OVERALL (a)            |        49/50 (98%)         42/50 (84%)               |
|ADJUSTED (b)           |        100.0%              100.0%                    |
|TERMINAL (d)           |        35/35 (100%)        30/30 (100%)              |
|FIRST INCIDENCE (DAYS) |          473                 423                     |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |                             P=0.552                  |
|INCIDENTAL TUMOR       |                             P=0.175N                 |
|LOGISTIC REGRESSION    |                             P=0.329N                 |
|COCHRAN-ARMITAGE       |                                                      |
|FISHER EXACT           |                             P=0.015N*                |
|==============================================================================|
|                                                                              |
|All Organs                                                                    |
|     Malignant Tumors                                                         |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |           #                   #                      |
|-----------            |                                                      |
|OVERALL (a)            |        23/50 (46%)         21/50 (42%)               |
|ADJUSTED (b)           |         49.9%               55.7%                    |
|TERMINAL (d)           |        12/35 (34%)         14/30 (47%)               |
|FIRST INCIDENCE (DAYS) |          477                 361                     |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |                             P=0.459                  |
|INCIDENTAL TUMOR       |                             P=0.560N                 |
|LOGISTIC REGRESSION    |                             P=0.525N                 |
|COCHRAN-ARMITAGE       |                                                      |
|FISHER EXACT           |                             P=0.420N                 |
|==============================================================================|
         DATE: 04/10/95                     EXPERIMENT: 05099 TEST: 07                                                 PAGE  19
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- SALICYLAZOSULFAPYRIDINE
                       TERMINAL SACRIFICE AT 105 WEEKS
|==============================================================================|
|DOSE                   |          0 MG/KG             337.5                   |
|                       |                              STOP                    |
|==============================================================================|
|                                                                              |
|All Organs                                                                    |
|     Malignant and Benign Tumors                                              |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |           #                   #                      |
|-----------            |                                                      |
|OVERALL (a)            |        49/50 (98%)         46/50 (92%)               |
|ADJUSTED (b)           |        100.0%              100.0%                    |
|TERMINAL (d)           |        35/35 (100%)        30/30 (100%)              |
|FIRST INCIDENCE (DAYS) |          473                 361                     |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |                             P=0.259                  |
|INCIDENTAL TUMOR       |                             P=0.814                  |
|LOGISTIC REGRESSION    |                             P=0.814                  |
|COCHRAN-ARMITAGE       |                                                      |
|FISHER EXACT           |                             P=0.181N                 |
|==============================================================================|
 (a)  Number of tumor-bearing animals / number of animals examined at site.
 (b)  Kaplan-Meier estimated lifetime tumor incidence after adjustment for 
      intercurrent mortality.
 (d)  Observed incidence at terminal kill.
 (f)  Beneath the control incidence are the P-values associated with the trend 
      test.  Beneath the dosed group incidence are the P-values corresponding to 
      pairwise comparisons between the controls and that dosed group.  The life
      table analysis regards tumors in animals dying  prior to terminal kill as
      being (directly or indirectly) the cause of death.  The incidental tumor 
      test regards these lesions as non-fatal.  Logistic regression is an alternative
      method for analyzing the incidence of non-fatal tumors.  The Cochran-Armitage
      and Fisher's exact tests compare directly the overall incidence rates.  
      For all tests, a negative trend is indicated by "N".
 (e)  Value of Statistic cannot be computed. 
 (I)  Interim sacrifice
 (T)  Terminal sacrifice
  #   Tumor rates based on number of animals necropsied.
  *   To the right of any statistical result, indicates significance at (P<=0.05).
  **  To the right of any statistical result, indicates significance at (P<=0.01).