TDMS Study 05106-01 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
DIETHYLPHTHALATE
NTP Experiment-Test: 05106-01 Report: PEIRPT05
Study Type: CHRONIC Date: 05/19/95
Route: SKIN APPLICATION Time: 20:47:32
Facility: Hazleton, Maryland
Chemical CAS #: 84-66-2
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05106-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIETHYLPHTHALATE Date: 05/19/95
Route: SKIN APPLICATION Time: 20:47:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0UL/RAT 100UL 300UL
UF RAT LF RAT HF
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60 60
Scheduled Sacrifice 9 10 10
Early Deaths
Moribund Sacrifice 12 12 17
Natural Death 9 10 10
Survivors
Terminal Sacrifice 30 28 21
Natural Death 2
Animals Examined Microscopically 60 52 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (58) (47) (58)
Liver (59) (52) (60)
Hepatocellular Adenoma 1 (2%) 1 (2%)
Mesentery (3) (3) (1)
Pancreas (59) (50) (60)
Adenoma 1 (2%)
Salivary Glands (59) (50) (60)
Stomach, Forestomach (59) (50) (60)
Squamous Cell Papilloma 1 (2%)
Stomach, Glandular (59) (50) (60)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (59) (51) (60)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (60) (50) (60)
Adenoma 4 (7%) 4 (8%) 6 (10%)
Adenoma, Multiple 1 (2%)
Adrenal Gland, Medulla (58) (50) (60)
Pheochromocytoma Malignant 1 (2%) 1 (2%)
Pheochromocytoma Benign 3 (5%) 1 (2%) 1 (2%)
Islets, Pancreatic (50) (50) (50)
Adenoma 3 (6%) 1 (2%) 3 (6%)
Carcinoma 2 (4%) 3 (6%)
Parathyroid Gland (54) (50) (57)
Adenoma 1 (2%)
Page 2
NTP Experiment-Test: 05106-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIETHYLPHTHALATE Date: 05/19/95
Route: SKIN APPLICATION Time: 20:47:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0UL/RAT 100UL 300UL
UF RAT LF RAT HF
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Pituitary Gland (59) (50) (58)
Pars Distalis, Adenoma 42 (71%) 33 (66%) 35 (60%)
Pars Distalis, Carcinoma 2 (3%) 2 (4%) 1 (2%)
Pars Intermedia, Adenoma 1 (2%)
Thyroid Gland (59) (50) (60)
Adenoma 1 (2%)
C-Cell, Adenoma 1 (2%)
C-Cell, Carcinoma 6 (10%) 5 (10%) 2 (3%)
Follicular Cell, Carcinoma 3 (5%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (2) (2) (2)
Basosquamous Tumor Malignant 1 (50%)
Fibrosarcoma 1 (50%)
Sarcoma 1 (50%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (53) (39) (50)
Adenoma 5 (9%) 2 (4%)
Carcinoma 2 (4%) 1 (3%) 2 (4%)
Ovary (59) (50) (60)
Carcinoma 1 (2%)
Uterus (59) (50) (60)
Leiomyoma 1 (2%)
Polyp Stromal 2 (3%) 3 (6%) 6 (10%)
Sarcoma Stromal 1 (2%)
Schwannoma Malignant 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (59) (50) (60)
Lymph Node, Mandibular (59) (50) (60)
Lymph Node, Mesenteric (59) (50) (60)
Spleen (60) (52) (60)
Hemangiosarcoma 1 (2%)
Thymus (53) (43) (52)
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 05106-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIETHYLPHTHALATE Date: 05/19/95
Route: SKIN APPLICATION Time: 20:47:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0UL/RAT 100UL 300UL
UF RAT LF RAT HF
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (59) (49) (60)
Adenocarcinoma 5 (8%) 3 (6%) 3 (5%)
Adenoma 1 (2%)
Fibroadenoma 22 (37%) 11 (22%) 7 (12%)
Fibroadenoma, Multiple 1 (2%) 1 (2%)
Fibroma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (57) (49) (60)
Osteosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (59) (50) (60)
Carcinoma, Metastatic 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (59) (50) (60)
Alveolar/Bronchiolar Adenoma 1 (2%)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Trachea (59) (50) (60)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1) (1) (1)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (51) (60)
Carcinoma 1 (2%)
Urinary Bladder (57) (47) (59)
Papilloma 1 (2%) 1 (2%)
Page 4
NTP Experiment-Test: 05106-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIETHYLPHTHALATE Date: 05/19/95
Route: SKIN APPLICATION Time: 20:47:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0UL/RAT 100UL 300UL
UF RAT LF RAT HF
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(60) *(52) *(60)
Leukemia Monocytic 1 (2%)
Leukemia Mononuclear 18 (30%) 15 (29%) 17 (28%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05106-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIETHYLPHTHALATE Date: 05/19/95
Route: SKIN APPLICATION Time: 20:47:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0UL/RAT 100UL 300UL
UF RAT LF RAT HF
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 58 48 49
Total Primary Neoplasms 133 90 98
Total Animals with Benign Neoplasms 53 41 41
Total Benign Neoplasms 88 55 68
Total Animals with Malignant Neoplasms 33 27 24
Total Malignant Neoplasms 45 35 30
Total Animals with Metastatic Neoplasms 1 2
Total Metastatic Neoplasm 1 2
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05106-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIETHYLPHTHALATE Date: 05/19/95
Route: SKIN APPLICATION Time: 20:47:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0UL/RAT 100UL 300UL
UM RAT LM RAT HM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60 60
Scheduled Sacrifice 10 10 9
Early Deaths
Moribund Sacrifice 31 38 26
Natural Death 15 6 19
Survivors
Moribund Sacrifice 1
Terminal Sacrifice 3 6 6
Animals Examined Microscopically 60 56 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (51) (47) (53)
Adenocarcinoma 2 (4%)
Liver (60) (50) (60)
Hepatocellular Adenoma 1 (2%) 1 (2%)
Mesentery (4) (3) (1)
Pancreas (60) (50) (59)
Fibrosarcoma 1 (2%)
Acinus, Adenoma 1 (2%)
Pharynx (1)
Papilloma 1 (100%)
Salivary Glands (58) (50) (59)
Fibrosarcoma 1 (2%)
Stomach, Forestomach (59) (50) (59)
Squamous Cell Papilloma 2 (3%) 2 (4%) 3 (5%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (50) (59)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (59) (50) (59)
Adenoma 1 (2%)
Adrenal Gland, Medulla (59) (50) (57)
Pheochromocytoma Malignant 1 (2%) 1 (2%)
Pheochromocytoma Benign 15 (25%) 8 (16%) 8 (14%)
Pheochromocytoma Benign, Multiple 1 (2%)
Islets, Pancreatic (50) (50) (49)
Page 7
NTP Experiment-Test: 05106-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIETHYLPHTHALATE Date: 05/19/95
Route: SKIN APPLICATION Time: 20:47:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0UL/RAT 100UL 300UL
UM RAT LM RAT HM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Adenoma 7 (14%) 10 (20%) 7 (14%)
Adenoma, Multiple 1 (2%)
Carcinoma 1 (2%)
Parathyroid Gland (57) (49) (57)
Carcinoma, Metastatic 1 (2%)
Pituitary Gland (54) (49) (58)
Pars Distalis, Adenoma 43 (80%) 41 (84%) 46 (79%)
Pars Distalis, Carcinoma 1 (2%)
Thyroid Gland (58) (50) (57)
C-Cell, Adenoma 3 (5%) 2 (4%) 2 (4%)
C-Cell, Carcinoma 1 (2%) 2 (4%)
Follicular Cell, Adenoma 1 (2%)
Follicular Cell, Carcinoma 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (4) (3) (2)
Fibroma 1 (50%)
Fibrosarcoma 1 (25%) 1 (33%)
Hemangiosarcoma 1 (25%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (58) (48) (59)
Preputial Gland (44) (46) (54)
Adenoma 1 (2%)
Carcinoma 1 (2%) 1 (2%) 2 (4%)
Prostate (58) (50) (58)
Seminal Vesicle (58) (50) (58)
Testes (60) (50) (59)
Bilateral, Interstitial Cell, Adenoma 1 (2%)
Interstitial Cell, Adenoma 4 (7%) 3 (6%) 8 (14%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (59) (49) (57)
Lymph Node (60) (50) (59)
Mediastinal, Carcinoma, Metastatic 1 (2%)
Lymph Node, Mandibular (58) (50) (58)
Lymph Node, Mesenteric (54) (50) (55)
Spleen (60) (50) (59)
Sarcoma 1 (2%)
Thymus (45) (37) (44)
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 05106-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIETHYLPHTHALATE Date: 05/19/95
Route: SKIN APPLICATION Time: 20:47:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0UL/RAT 100UL 300UL
UM RAT LM RAT HM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (54) (38) (52)
Fibroadenoma 1 (3%)
Fibroma 2 (4%) 1 (3%)
Sarcoma 1 (3%)
Skin (59) (56) (60)
Keratoacanthoma 1 (2%) 1 (2%)
Face, Papilloma 1 (2%)
Lip, Papilloma 1 (2%)
Other, Fibroma 1 (2%)
Site of Application-Mass, Adenoma 1 (2%)
Thoracic, Keratoacanthoma 1 (2%)
Skin, Site of Application-No Mass (60) (55) (60)
Basal Cell Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (50) (59)
Astrocytoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (50) (60)
Alveolar/Bronchiolar Adenoma 1 (2%)
Carcinoma, Metastatic 1 (2%)
Nose (60) (50) (58)
Adenoma 1 (2%)
Carcinoma, Metastatic 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1) (2) (3)
Papilloma 1 (50%) 2 (67%)
Zymbal's Gland (3)
Carcinoma 1 (33%)
____________________________________________________________________________________________________________________________________
Page 9
NTP Experiment-Test: 05106-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIETHYLPHTHALATE Date: 05/19/95
Route: SKIN APPLICATION Time: 20:47:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0UL/RAT 100UL 300UL
UM RAT LM RAT HM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (50) (60)
Lipoma 1 (2%)
Renal Tubule, Adenoma 1 (2%) 1 (2%) 1 (2%)
Urethra (1)
Transitional Epithelium, Carcinoma 1 (100%)
Urinary Bladder (58) (50) (56)
Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(60) *(56) *(60)
Leukemia Mononuclear 9 (15%) 12 (21%) 13 (22%)
Lymphoma Malignant Histiocytic 1 (2%)
Lymphoma Malignant Lymphocytic 1 (2%)
Mesothelioma Benign 2 (3%)
Mesothelioma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 10
NTP Experiment-Test: 05106-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIETHYLPHTHALATE Date: 05/19/95
Route: SKIN APPLICATION Time: 20:47:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0UL/RAT 100UL 300UL
UM RAT LM RAT HM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 52 49 55
Total Primary Neoplasms 102 101 109
Total Animals with Benign Neoplasms 51 47 52
Total Benign Neoplasms 85 78 85
Total Animals with Malignant Neoplasms 17 21 23
Total Malignant Neoplasms 17 23 24
Total Animals with Metastatic Neoplasms 1 1
Total Metastatic Neoplasm 3 1
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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