TDMS Study 05155-03 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
P-NITROBENZOIC ACID
NTP Experiment-Test: 05155-03 Report: PEIRPT05
Study Type: CHRONIC Date: 05/08/95
Route: DOSED FEED Time: 17:03:39
Facility: Southern Research Institute
Chemical CAS #: 62-23-7
Lock Date: 02/15/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05155-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 05/08/95
Route: DOSED FEED Time: 17:03:39
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.0% 0.125% 0.25% 0.5%
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60 60 60
Scheduled Sacrifice 10 10 10 10
Early Deaths
Moribund Sacrifice 21 23 27 26
Natural Death 2 4 2 3
Survivors
Terminal Sacrifice 27 23 21 21
Animals Examined Microscopically 60 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (60) (60) (60) (60)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Intestine Large, Colon (60) (58) (60) (60)
Leiomyosarcoma, Metastatic, Uterus 1 (2%)
Intestine Large, Cecum (60) (57) (60) (59)
Intestine Small, Duodenum (60) (60) (60) (59)
Intestine Small, Ileum (60) (57) (60) (58)
Liver (60) (60) (60) (60)
Hepatocellular Adenoma 2 (3%)
Sarcoma, Metastatic, Mesentery 1 (2%)
Mesentery (11) (9) (10) (6)
Sarcoma 1 (10%)
Schwannoma Malignant, Metastatic, Uterus 1 (10%)
Pancreas (60) (60) (59) (59)
Acinar Cell, Adenoma 1 (2%)
Pharynx (1)
Palate, Squamous Cell Papilloma 1 (100%)
Salivary Glands (60) (60) (60) (60)
Stomach, Forestomach (60) (60) (59) (59)
Stomach, Glandular (60) (60) (59) (59)
Tongue (1) (1)
Squamous Cell Papilloma 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (60) (60) (60)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 05155-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 05/08/95
Route: DOSED FEED Time: 17:03:39
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.0% 0.125% 0.25% 0.5%
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (59) (60) (60) (60)
Osteosarcoma, Metastatic, Bone 1 (2%)
Adrenal Medulla (59) (60) (60) (60)
Osteosarcoma, Metastatic, Bone 1 (2%)
Pheochromocytoma Benign 2 (3%) 1 (2%) 3 (5%)
Islets, Pancreatic (60) (60) (59) (59)
Adenoma 1 (2%)
Pituitary Gland (60) (60) (59) (59)
Osteosarcoma, Metastatic, Bone 1 (2%)
Pars Distalis, Adenoma 20 (33%) 29 (48%) 26 (44%) 26 (44%)
Pars Distalis, Carcinoma 1 (2%)
Pars Nervosa, Ganglioneuroma 1 (2%)
Thyroid Gland (60) (59) (60) (60)
C-Cell, Adenoma 9 (15%) 4 (7%) 5 (8%) 2 (3%)
C-Cell, Adenoma, Multiple 1 (2%)
C-Cell, Carcinoma 1 (2%) 2 (3%)
Follicular Cell, Carcinoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (60) (59) (59) (60)
Adenoma 4 (7%) 12 (20%) 9 (15%) 11 (18%)
Carcinoma 1 (2%) 2 (3%) 4 (7%) 3 (5%)
Bilateral, Adenoma 1 (2%) 1 (2%)
Bilateral, Carcinoma 1 (2%) 1 (2%)
Ovary (60) (60) (60) (59)
Granulosa Cell Tumor Benign 1 (2%)
Neoplasm NOS 1 (2%)
Uterus (60) (60) (60) (59)
Histiocytic Sarcoma 1 (2%)
Leiomyosarcoma 1 (2%)
Endometrium, Polyp Stromal 5 (8%) 13 (22%) 14 (23%) 6 (10%)
Endometrium, Polyp Stromal, Multiple 1 (2%) 1 (2%)
Endometrium, Sarcoma Stromal 1 (2%) 2 (3%)
Endometrium, Schwannoma Malignant 1 (2%) 2 (3%)
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 05155-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 05/08/95
Route: DOSED FEED Time: 17:03:39
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.0% 0.125% 0.25% 0.5%
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (60) (60) (60)
Lymph Node (14) (14) (11) (10)
Renal, Sarcoma, Metastatic, Mesentery 1 (9%)
Lymph Node, Mandibular (60) (60) (60) (60)
Lymph Node, Mesenteric (59) (60) (60) (59)
Spleen (60) (60) (60) (59)
Fibrosarcoma 1 (2%)
Sarcoma, Metastatic, Mesentery 1 (2%)
Thymus (59) (58) (60) (60)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (60) (60) (60) (60)
Adenoma 1 (2%)
Carcinoma 2 (3%) 2 (3%) 3 (5%) 2 (3%)
Fibroadenoma 17 (28%) 16 (27%) 19 (32%) 19 (32%)
Fibroadenoma, Multiple 5 (8%) 7 (12%) 7 (12%) 5 (8%)
Skin (60) (60) (60) (60)
Basal Cell Carcinoma 1 (2%)
Basosquamous Tumor Malignant 1 (2%)
Squamous Cell Papilloma 1 (2%)
Subcutaneous Tissue, Fibroma 2 (3%) 1 (2%) 3 (5%)
Subcutaneous Tissue, Lipoma 1 (2%)
Subcutaneous Tissue, Schwannoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (60) (60) (60)
Osteosarcoma 1 (2%) 1 (2%) 1 (2%)
Skeletal Muscle (1) (1)
Rhabdomyosarcoma 1 (100%)
Sarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (60) (60) (60)
Astrocytoma NOS 1 (2%)
Glioma Malignant 1 (2%)
Peripheral Nerve (2) (4) (2)
Schwannoma Malignant 1 (25%)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 05155-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 05/08/95
Route: DOSED FEED Time: 17:03:39
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.0% 0.125% 0.25% 0.5%
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (60) (60) (60)
Alveolar/Bronchiolar Adenoma 1 (2%) 1 (2%)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Osteosarcoma, Multiple, Metastatic, Bone 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Nose (60) (60) (60) (59)
Trachea (60) (60) (60) (60)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (60) (60) (60)
Pelvis, Transitional Epithelium, Mesenchymal
Nos 1 (2%)
Urinary Bladder (60) (60) (60) (60)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(60) *(60) *(60) *(60)
Histiocytic Sarcoma 1 (2%)
Leukemia Mononuclear 17 (28%) 12 (20%) 3 (5%)
Mesothelioma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05155-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 05/08/95
Route: DOSED FEED Time: 17:03:39
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.0% 0.125% 0.25% 0.5%
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 46 53 55 49
Total Primary Neoplasms 97 109 113 87
Total Animals with Benign Neoplasms 42 46 48 45
Total Benign Neoplasms 70 85 89 76
Total Animals with Malignant Neoplasms 21 20 22 10
Total Malignant Neoplasms 27 22 23 11
Total Animals with Metastatic Neoplasms 2 2 1
Total Metastatic Neoplasm 5 4 3
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 2 1
Total Uncertain Neoplasms 2 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05155-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 05/08/95
Route: DOSED FEED Time: 17:03:39
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.0% 0.125% 0.25% 0.5%
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60 60 60
Scheduled Sacrifice 10 10 10 10
Early Deaths
Moribund Sacrifice 32 34 34 25
Natural Death 6 3 3 4
Survivors
Terminal Sacrifice 12 13 13 21
Animals Examined Microscopically 60 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (59) (60) (59) (59)
Polyp Adenomatous 1 (2%)
Intestine Large, Rectum (59) (60) (59) (60)
Intestine Large, Cecum (59) (60) (59) (60)
Hemangiosarcoma 1 (2%)
Intestine Small, Duodenum (58) (58) (59) (60)
Intestine Small, Jejunum (59) (59) (59) (60)
Carcinoma 2 (3%)
Intestine Small, Ileum (58) (59) (59) (60)
Liver (59) (60) (60) (60)
Hepatocellular Carcinoma 3 (5%) 2 (3%)
Hepatocellular Adenoma 2 (3%) 2 (3%) 1 (2%) 2 (3%)
Hepatocellular Adenoma, Multiple 2 (3%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Mesentery (18) (14) (15) (20)
Carcinoma, Metastatic, Kidney 1 (7%)
Schwannoma Malignant, Metastatic, Peripheral
Nerve 1 (7%)
Pancreas (59) (60) (59) (60)
Schwannoma Malignant, Metastatic, Peripheral
Nerve 1 (2%)
Acinar Cell, Adenoma 2 (3%) 3 (5%)
Pharynx (1) (3)
Palate, Squamous Cell Papilloma 1 (100%) 2 (67%)
Salivary Glands (59) (59) (60) (60)
Schwannoma Malignant 1 (2%) 1 (2%)
Stomach, Forestomach (60) (60) (60) (60)
Stomach, Glandular (60) (59) (59) (60)
Leiomyoma 1 (2%)
Tongue (2)
Squamous Cell Papilloma 1 (50%)
Page 7
NTP Experiment-Test: 05155-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 05/08/95
Route: DOSED FEED Time: 17:03:39
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.0% 0.125% 0.25% 0.5%
____________________________________________________________________________________________________________________________________
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (60) (60) (60)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (60) (60) (60) (60)
Adenoma 1 (2%)
Adrenal Medulla (60) (60) (60) (60)
Pheochromocytoma Malignant 2 (3%) 1 (2%) 2 (3%)
Pheochromocytoma Benign 8 (13%) 7 (12%) 6 (10%) 11 (18%)
Bilateral, Pheochromocytoma Benign 2 (3%) 4 (7%) 2 (3%) 1 (2%)
Islets, Pancreatic (59) (60) (59) (60)
Adenoma 2 (3%) 1 (2%) 2 (3%)
Carcinoma 1 (2%)
Parathyroid Gland (57) (59) (57) (59)
Pituitary Gland (59) (60) (59) (59)
Pars Distalis, Adenoma 20 (34%) 14 (23%) 20 (34%) 13 (22%)
Pars Intermedia, Adenoma 1 (2%)
Thyroid Gland (59) (59) (59) (60)
C-Cell, Adenoma 4 (7%) 2 (3%) 2 (3%) 3 (5%)
C-Cell, Carcinoma 1 (2%) 3 (5%) 1 (2%)
Follicular Cell, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (2) (2) (2)
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GENITAL SYSTEM
Epididymis (60) (60) (59) (60)
Preputial Gland (60) (60) (59) (60)
Adenoma 4 (7%) 2 (3%) 5 (8%) 4 (7%)
Carcinoma 1 (2%) 1 (2%) 3 (5%) 5 (8%)
Bilateral, Adenoma 1 (2%)
Bilateral, Carcinoma 1 (2%) 1 (2%)
Duct, Squamous Cell Papilloma 1 (2%)
Prostate (60) (60) (60) (60)
Seminal Vesicle (60) (60) (59) (60)
Schwannoma Malignant, Metastatic, Peripheral
Nerve 1 (2%)
Testes (60) (60) (59) (60)
Bilateral, Interstitial Cell, Adenoma 38 (63%) 43 (72%) 42 (71%) 21 (35%)
Page 8
NTP Experiment-Test: 05155-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 05/08/95
Route: DOSED FEED Time: 17:03:39
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.0% 0.125% 0.25% 0.5%
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont
Interstitial Cell, Adenoma 15 (25%) 10 (17%) 11 (19%) 16 (27%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (60) (60) (60)
Lymph Node (26) (26) (32) (15)
Mediastinal, Carcinoma, Metastatic, Kidney 1 (3%)
Pancreatic, Carcinoma, Metastatic, Kidney 1 (3%)
Renal, Carcinoma, Metastatic, Kidney 1 (3%)
Lymph Node, Mandibular (59) (59) (59) (60)
Lymph Node, Mesenteric (59) (60) (59) (60)
Carcinoma, Metastatic, Kidney 1 (2%)
Spleen (60) (60) (60) (60)
Fibrosarcoma 1 (2%)
Histiocytic Sarcoma 2 (3%)
Thymus (57) (59) (58) (56)
Epithelial Cell, Thymoma Benign 1 (2%) 1 (2%) 2 (3%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (59) (57) (58) (54)
Fibroadenoma 3 (5%) 1 (2%) 4 (7%) 2 (4%)
Skin (60) (60) (60) (60)
Basal Cell Adenoma 1 (2%) 1 (2%)
Keratoacanthoma 3 (5%) 3 (5%) 3 (5%) 2 (3%)
Squamous Cell Papilloma 2 (3%)
Trichoepithelioma 1 (2%)
Subcutaneous Tissue, Fibroma 4 (7%) 6 (10%) 4 (7%) 7 (12%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%) 4 (7%)
Subcutaneous Tissue, Lipoma 1 (2%) 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (60) (60) (60)
Osteosarcoma 2 (3%) 1 (2%) 1 (2%)
Skeletal Muscle (1) (1) (1)
Schwannoma Malignant, Metastatic, Peripheral
Nerve 1 (100%)
____________________________________________________________________________________________________________________________________
Page 9
NTP Experiment-Test: 05155-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 05/08/95
Route: DOSED FEED Time: 17:03:39
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.0% 0.125% 0.25% 0.5%
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (60) (60) (60)
Glioma Malignant 1 (2%)
Peripheral Nerve (2) (5) (1)
Schwannoma Malignant 1 (50%) 1 (20%)
Spinal Cord (2) (4) (2)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (60) (60) (60)
Alveolar/Bronchiolar Adenoma 1 (2%) 3 (5%)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Carcinoma, Multiple, Metastatic, Kidney 1 (2%)
Osteosarcoma, Multiple, Metastatic, Bone 1 (2%) 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Nose (60) (60) (60) (60)
Nasolacrimal Duct, Squamous Cell Carcinoma 1 (2%)
Trachea (59) (59) (60) (60)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1) (2)
Pinna, Fibrosarcoma 1 (100%)
Zymbal's Gland (2)
Adenoma 1 (50%)
Carcinoma 1 (50%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (60) (60) (60)
Pelvis, Transitional Epithelium, Papilloma 1 (2%)
Renal Tubule, Adenoma 1 (2%)
Renal Tubule, Carcinoma 1 (2%)
Urinary Bladder (60) (60) (59) (60)
Leiomyosarcoma 1 (2%)
Schwannoma Malignant, Metastatic, Peripheral
Nerve 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(60) *(60) *(60) *(60)
Histiocytic Sarcoma 2 (3%)
* Number of animals with any tissue examined microscopically
Page 10
NTP Experiment-Test: 05155-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 05/08/95
Route: DOSED FEED Time: 17:03:39
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.0% 0.125% 0.25% 0.5%
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont
Multiple Organs *(60) *(60) *(60) *(60)
Leukemia Mononuclear 29 (48%) 36 (60%) 26 (43%) 2 (3%)
Mesothelioma Benign 1 (2%)
Mesothelioma Malignant 2 (3%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
Page 11
NTP Experiment-Test: 05155-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC P-NITROBENZOIC ACID Date: 05/08/95
Route: DOSED FEED Time: 17:03:39
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.0% 0.125% 0.25% 0.5%
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 57 59 59 50
Total Primary Neoplasms 158 149 155 113
Total Animals with Benign Neoplasms 56 57 58 45
Total Benign Neoplasms 111 104 117 89
Total Animals with Malignant Neoplasms 39 39 34 20
Total Malignant Neoplasms 47 45 38 24
Total Animals with Metastatic Neoplasms 1 2 2
Total Metastatic Neoplasm 1 5 8
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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