TDMS Study 05163-01 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
C. I. ACID RED 114
NTP Experiment-Test: 05163-01 Report: PEIRPT05
Study Type: CHRONIC Date: 09/17/94
Route: DOSED WATER Time: 21:51:44
Facility: Hazleton Laboratories America, Inc.
Chemical CAS #: 6459-94-5
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05163-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC C. I. ACID RED 114 Date: 09/17/94
Route: DOSED WATER Time: 21:51:44
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.015 0.03 0.06
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 70 45 75 70
Scheduled Sacrifice 20 10 10 20
Early Deaths
Dead 4 6 17 13
Moribund 10 16 41 37
Accident 1
Survivors
Terminal Sacrifice 36 13 6
Animals Examined Microscopically 50 35 65 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (35) (64) (50)
Intestine Large, Cecum (50) (35) (63) (49)
Intestine Large, Colon (50) (35) (63) (48)
Adenocarcinoma, Cystic, Mucinous 1 (2%)
Polyp Adenomatous 1 (3%) 1 (2%)
Intestine Large, Rectum (50) (35) (64) (49)
Polyp Adenomatous 1 (2%)
Intestine Small, Duodenum (50) (35) (63) (50)
Adenocarcinoma, Cystic, Mucinous 1 (2%)
Polyp Adenomatous 1 (2%)
Intestine Small, Ileum (50) (35) (63) (50)
Intestine Small, Jejunum (50) (35) (63) (50)
Polyp Adenomatous 1 (2%)
Liver (50) (35) (64) (50)
Hepatocellular Carcinoma 6 (9%) 3 (6%)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Neoplastic Nodule 11 (17%) 6 (12%)
Neoplastic Nodule, Multiple 4 (6%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (2%)
Mesentery (4) (1) (4) (11)
Schwannoma Malignant 1 (9%)
Pancreas (50) (35) (62) (50)
Pharynx (1) (5) (4)
Squamous Cell Carcinoma 1 (20%) 2 (50%)
Squamous Cell Papilloma 1 (100%) 4 (80%) 1 (25%)
Salivary Glands (48) (35) (64) (50)
Schwannoma Malignant 1 (2%)
Stomach, Forestomach (50) (35) (64) (50)
Sarcoma 1 (2%)
Stomach, Glandular (50) (35) (64) (50)
Page 2
NTP Experiment-Test: 05163-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC C. I. ACID RED 114 Date: 09/17/94
Route: DOSED WATER Time: 21:51:44
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.015 0.03 0.06
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont
Tongue (2) (4) (4)
Squamous Cell Carcinoma 2 (50%)
Squamous Cell Papilloma 2 (100%) 2 (50%) 3 (75%)
Tooth (1) (1) (2)
Odontoma 2 (100%)
Peridontal Tissue, Histiocytic Sarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (35) (64) (49)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (35) (64) (50)
Adenoma 1 (2%)
Adrenal Gland, Medulla (50) (35) (64) (50)
Pheochromocytoma Malignant 1 (2%)
Pheochromocytoma Benign 1 (2%) 3 (9%) 4 (6%) 1 (2%)
Islets, Pancreatic (50) (35) (63) (49)
Adenoma 1 (2%)
Carcinoma 1 (2%)
Pituitary Gland (50) (35) (64) (49)
Pars Distalis, Adenoma 25 (50%) 17 (49%) 17 (27%) 5 (10%)
Thyroid Gland (50) (35) (64) (50)
C-Cell, Adenoma 6 (12%) 2 (6%) 2 (3%) 3 (6%)
C-Cell, Carcinoma 6 (12%) 2 (3%)
Follicular Cell, Adenoma 1 (3%) 3 (5%)
Follicular Cell, Carcinoma 2 (6%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1) (2)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (48) (32) (62) (50)
Adenoma 7 (15%) 9 (28%) 10 (16%) 10 (20%)
Carcinoma 4 (8%) 9 (28%) 17 (27%) 13 (26%)
Bilateral, Adenoma 1 (3%)
Bilateral, Carcinoma 2 (3%) 2 (4%)
Ovary (50) (35) (64) (49)
Granulosa Cell Tumor NOS 1 (2%)
Periovarian Tissue, Sarcoma Stromal,
Page 3
NTP Experiment-Test: 05163-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC C. I. ACID RED 114 Date: 09/17/94
Route: DOSED WATER Time: 21:51:44
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.015 0.03 0.06
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont
Metastatic, Uterus 1 (2%)
Uterus (50) (35) (64) (49)
Adenoma 1 (2%)
Polyp Stromal 4 (8%) 6 (17%) 7 (11%) 2 (4%)
Polyp Stromal, Multiple 2 (6%) 1 (2%)
Sarcoma Stromal 1 (2%) 2 (6%) 2 (3%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (35) (63) (50)
Histiocytic Sarcoma 1 (2%)
Lymph Node (50) (35) (64) (49)
Schwannoma Malignant, Metastatic, Peripheral
Nerve 1 (2%)
Mediastinal, Histiocytic Sarcoma 1 (2%)
Lymph Node, Mandibular (46) (35) (64) (48)
Histiocytic Sarcoma 1 (2%)
Lymph Node, Mesenteric (50) (35) (64) (48)
Spleen (50) (35) (63) (50)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Thymus (40) (30) (59) (42)
Thymoma Benign 1 (3%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (49) (35) (58) (45)
Adenoacanthoma 1 (3%)
Adenocarcinoma 3 (9%) 6 (10%) 2 (4%)
Adenocarcinoma, Multiple 1 (2%)
Adenoma 1 (2%) 1 (3%) 4 (7%)
Fibroadenoma 16 (33%) 10 (29%) 8 (14%)
Fibroadenoma, Multiple 3 (6%) 3 (9%) 4 (7%) 1 (2%)
Sarcoma 1 (2%)
Skin (50) (35) (65) (49)
Basal Cell Adenoma 2 (6%) 5 (8%) 3 (6%)
Basal Cell Adenoma, Multiple 1 (3%)
Basal Cell Carcinoma 1 (3%) 2 (3%) 2 (4%)
Keratoacanthoma 1 (2%)
Squamous Cell Carcinoma 3 (5%)
Squamous Cell Papilloma 1 (2%) 1 (2%)
Subcutaneous Tissue, Fibroma 3 (6%) 3 (5%) 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%)
Subcutaneous Tissue, Lipoma 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 05163-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC C. I. ACID RED 114 Date: 09/17/94
Route: DOSED WATER Time: 21:51:44
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.015 0.03 0.06
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (3) (7) (10)
Carcinoma, Metastatic, Clitoral Gland 1 (14%)
Squamous Cell Carcinoma, Metastatic, Pharynx 1 (10%)
Skeletal Muscle (1) (1)
Adenocarcinoma, Metastatic, Mammary Gland 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (49) (35) (64) (50)
Astrocytoma Malignant 1 (2%)
Granular Cell Tumor Benign 1 (2%)
Oligodendroglioma Malignant 1 (2%)
Squamous Cell Carcinoma, Metastatic, Pharynx 1 (2%)
Peripheral Nerve (1)
Schwannoma Malignant 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (35) (65) (50)
Alveolar/Bronchiolar Adenoma 1 (2%) 2 (6%) 8 (12%) 3 (6%)
Alveolar/Bronchiolar Adenoma, Multiple 1 (2%)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Basal Cell Carcinoma, Metastatic, Skin 1 (2%)
Carcinoma, Metastatic 1 (2%)
Carcinoma, Metastatic, Clitoral Gland 1 (3%) 1 (2%)
Carcinoma, Metastatic, Zymbal's Gland 3 (5%)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Sarcoma 1 (2%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (2%)
Nose (50) (35) (63) (49)
Squamous Cell Carcinoma, Metastatic, Pharynx 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (2)
Squamous Cell Carcinoma, Metastatic, Pharynx 1 (50%)
Zymbal's Gland (50) (35) (63) (49)
Adenoma 2 (3%) 6 (12%)
Carcinoma 3 (9%) 17 (27%) 13 (27%)
____________________________________________________________________________________________________________________________________
Page 5
NTP Experiment-Test: 05163-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC C. I. ACID RED 114 Date: 09/17/94
Route: DOSED WATER Time: 21:51:44
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.015 0.03 0.06
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (35) (64) (50)
Renal Tubule, Adenocarcinoma 1 (3%)
Transitional Epithelium, Carcinoma 1 (2%)
Urinary Bladder (49) (35) (64) (49)
Transitional Epithelium, Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(35) *(65) *(50)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Leukemia 1 (2%) 1 (2%)
Leukemia Mononuclear 12 (24%) 13 (37%) 17 (26%) 4 (8%)
Lymphoma Malignant Histiocytic 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 6
NTP Experiment-Test: 05163-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC C. I. ACID RED 114 Date: 09/17/94
Route: DOSED WATER Time: 21:51:44
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.015 0.03 0.06
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 47 35 61 47
Total Primary Neoplasms 96 99 192 105
Total Animals with Benign Neoplasms 41 31 50 32
Total Benign Neoplasms 70 64 104 54
Total Animals with Malignant Neoplasms 22 25 52 42
Total Malignant Neoplasms 26 35 87 51
Total Animals with Metastatic Neoplasms 1 1 5 5
Total Metastatic Neoplasm 1 2 6 8
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1
Total Uncertain Neoplasms 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 7
NTP Experiment-Test: 05163-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC C. I. ACID RED 114 Date: 09/17/94
Route: DOSED WATER Time: 21:51:44
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.007 0.015 0.03
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 70 45 75 70
Scheduled Sacrifice 19 10 10 20
Early Deaths
Dead 13 11 16 16
Moribund 13 9 23 33
Survivors
Terminal Sacrifice 23 15 26 1
Dead 1
Surplus 1
Animals Examined Microscopically 50 35 65 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (50) (35) (64) (49)
Intestine Large, Colon (50) (35) (64) (50)
Intestine Small, Ileum (50) (35) (64) (49)
Intestine Small, Jejunum (50) (35) (64) (49)
Adenocarcinoma, Cystic, Mucinous 1 (2%)
Leiomyoma 1 (3%)
Liver (50) (35) (65) (50)
Carcinoma, Metastatic, Islets, Pancreatic 1 (2%)
Hepatocellular Carcinoma 1 (3%) 5 (8%) 7 (14%)
Hepatocellular Carcinoma, Multiple 1 (2%)
Neoplasm NOS, Metastatic, Uncertain Primary
Site 1 (3%)
Neoplastic Nodule 2 (4%) 8 (12%) 12 (24%)
Neoplastic Nodule, Multiple 1 (3%) 2 (3%) 3 (6%)
Mesentery (11) (6) (1) (6)
Carcinoma, Metastatic, Islets, Pancreatic 1 (9%)
Pancreas (50) (35) (64) (49)
Pharynx (1)
Squamous Cell Papilloma 1 (100%)
Salivary Glands (49) (35) (64) (50)
Carcinoma 1 (2%)
Stomach, Glandular (50) (35) (65) (50)
Tongue (3)
Squamous Cell Papilloma 2 (67%)
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 05163-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC C. I. ACID RED 114 Date: 09/17/94
Route: DOSED WATER Time: 21:51:44
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.007 0.015 0.03
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (35) (65) (50)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
Schwannoma NOS 1 (2%)
Endocardium, Schwannoma NOS 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (35) (63) (50)
Bilateral, Pheochromocytoma Benign 1 (3%)
Adrenal Gland, Medulla (50) (35) (63) (49)
Pheochromocytoma Malignant 2 (4%) 3 (5%) 2 (4%)
Pheochromocytoma Benign 15 (30%) 10 (29%) 19 (30%) 13 (27%)
Bilateral, Pheochromocytoma Benign 1 (2%) 1 (3%) 5 (8%) 7 (14%)
Islets, Pancreatic (50) (35) (65) (50)
Adenoma 1 (2%)
Carcinoma 1 (2%) 1 (3%)
Pituitary Gland (50) (35) (65) (47)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%)
Pars Distalis, Adenoma 12 (24%) 7 (20%) 14 (22%) 4 (9%)
Thyroid Gland (50) (35) (65) (49)
C-Cell, Adenoma 5 (10%) 2 (6%) 6 (9%) 3 (6%)
C-Cell, Carcinoma 1 (2%) 1 (3%) 1 (2%)
Follicular Cell, Adenoma 1 (2%) 2 (4%)
Follicular Cell, Carcinoma 2 (4%) 2 (6%) 2 (3%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1) (3) (3)
Carcinoma, Metastatic, Zymbal's Gland 1 (33%)
Schwannoma Malignant, Metastatic, Skin 1 (33%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (35) (64) (50)
Preputial Gland (44) (34) (60) (48)
Adenoma 2 (5%) 1 (3%) 2 (3%) 1 (2%)
Carcinoma 4 (9%) 2 (6%) 3 (5%) 4 (8%)
Bilateral, Carcinoma 1 (2%) 1 (3%)
Prostate (50) (34) (64) (50)
Seminal Vesicle (49) (34) (65) (48)
Testes (50) (35) (64) (50)
Bilateral, Interstitial Cell, Adenoma 37 (74%) 24 (69%) 51 (80%) 38 (76%)
Interstitial Cell, Adenoma 7 (14%) 11 (31%) 8 (13%) 5 (10%)
Page 9
NTP Experiment-Test: 05163-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC C. I. ACID RED 114 Date: 09/17/94
Route: DOSED WATER Time: 21:51:44
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.007 0.015 0.03
____________________________________________________________________________________________________________________________________
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (35) (64) (50)
Lymph Node (49) (35) (65) (50)
Lymph Node, Mandibular (49) (35) (65) (49)
Lymph Node, Mesenteric (49) (35) (64) (50)
Spleen (50) (35) (64) (50)
Carcinoma, Metastatic, Islets, Pancreatic 1 (2%)
Fibrosarcoma 1 (2%)
Lipoma 1 (2%)
Thymus (41) (22) (47) (40)
Neoplasm NOS 1 (5%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (3%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (46) (31) (61) (37)
Adenoma 1 (3%)
Fibroadenoma 2 (4%) 3 (5%) 1 (3%)
Skin (50) (35) (65) (50)
Basal Cell Adenoma 1 (2%) 3 (9%) 12 (18%) 11 (22%)
Basal Cell Adenoma, Multiple 1 (3%) 14 (22%) 19 (38%)
Basal Cell Carcinoma 1 (3%) 3 (5%) 5 (10%)
Basal Cell Carcinoma, Multiple 2 (3%) 1 (2%)
Keratoacanthoma 1 (2%) 1 (3%) 4 (6%) 5 (10%)
Keratoacanthoma, Multiple 2 (4%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (2%)
Squamous Cell Carcinoma 2 (6%) 6 (9%) 6 (12%)
Squamous Cell Carcinoma, Multiple 2 (3%) 1 (2%)
Squamous Cell Papilloma 1 (2%) 3 (5%) 2 (4%)
Sebaceous Gland, Adenoma 1 (3%) 4 (6%) 3 (6%)
Sebaceous Gland, Adenoma, Multiple 1 (2%) 2 (4%)
Sebaceous Gland, Carcinoma 1 (2%) 1 (2%)
Subcutaneous Tissue, Chordoma, Metastatic 1 (2%)
Subcutaneous Tissue, Fibroma 4 (8%) 3 (9%) 5 (8%) 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%)
Subcutaneous Tissue, Lipoma 1 (2%)
Subcutaneous Tissue, Schwannoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
Page 10
NTP Experiment-Test: 05163-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC C. I. ACID RED 114 Date: 09/17/94
Route: DOSED WATER Time: 21:51:44
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.007 0.015 0.03
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (2)
Sternum, Hemangiosarcoma 1 (50%)
Skeletal Muscle (1) (1)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (35) (64) (50)
Astrocytoma Malignant 1 (3%) 1 (2%)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%)
Glioma Malignant 1 (2%)
Peripheral Nerve (1)
Schwannoma Malignant 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (35) (65) (50)
Alveolar/Bronchiolar Adenoma 2 (6%) 1 (2%) 3 (6%)
Alveolar/Bronchiolar Carcinoma 2 (4%) 1 (2%)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (2%)
Squamous Cell Carcinoma, Metastatic, Skin 1 (3%) 2 (4%)
Nose (50) (35) (65) (50)
Squamous Cell Carcinoma 1 (2%)
Trachea (50) (35) (65) (50)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (2) (1)
Zymbal's Gland (50) (35) (64) (50)
Adenoma 1 (2%) 1 (2%)
Carcinoma 7 (11%) 6 (12%)
Schwannoma Malignant, Metastatic, Skin 1 (2%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (35) (65) (50)
Squamous Cell Carcinoma, Metastatic, Skin 1 (2%)
Renal Tubule, Adenoma 1 (2%)
Transitional Epithelium, Carcinoma 1 (2%)
Urinary Bladder (50) (34) (64) (50)
Page 11
NTP Experiment-Test: 05163-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC C. I. ACID RED 114 Date: 09/17/94
Route: DOSED WATER Time: 21:51:44
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.007 0.015 0.03
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(35) *(65) *(50)
Leukemia Mononuclear 20 (40%) 20 (57%) 37 (57%) 12 (24%)
Lymphoma Malignant 1 (2%) 1 (2%)
Mesothelioma Malignant 4 (8%) 6 (17%) 4 (6%) 3 (6%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 12
NTP Experiment-Test: 05163-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC C. I. ACID RED 114 Date: 09/17/94
Route: DOSED WATER Time: 21:51:44
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.007 0.015 0.03
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 49 35 64 49
Total Primary Neoplasms 135 110 246 196
Total Animals with Benign Neoplasms 48 35 61 45
Total Benign Neoplasms 92 71 166 141
Total Animals with Malignant Neoplasms 33 27 54 42
Total Malignant Neoplasms 43 38 78 55
Total Animals with Metastatic Neoplasms 5 7 4 7
Total Metastatic Neoplasm 14 23 7 18
Total Animals with Malignant Neoplasms 1 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1 2
Total Uncertain Neoplasms 1 2
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 13
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