TDMS Study 05172-01 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE
NTP Experiment-Test: 05172-01 Report: PEIRPT05
Study Type: CHRONIC Date: 09/18/94
Route: DOSED WATER Time: 06:28:49
Facility: Hazleton Laboratories America, Inc.
Chemical CAS #: 20325400
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05172-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 09/18/94
Route: DOSED WATER Time: 06:28:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 80 PPM 170 PPM 330 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 70 45 75 70
Scheduled Sacrifice 10 10
Early Deaths
Moribund 10 27 60 51
Dead 5 3 9 9
Survivors
Terminal Sacrifice 45 15 6
Animals Examined Microscopically 60 45 75 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (60) (44) (75) (58)
Intestine Large, Colon (60) (44) (75) (59)
Sarcoma Stromal, Metastatic, Uterus 1 (1%)
Descending Colon, Adenocarcinoma 1 (2%)
Descending Colon, Polyp Adenomatous 1 (1%) 2 (3%)
Intestine Large, Rectum (60) (43) (74) (59)
Adenocarcinoma 1 (2%)
Polyp Adenomatous 1 (2%)
Intestine Small, Duodenum (60) (43) (73) (58)
Adenocarcinoma, Cystic, Mucinous 1 (2%)
Carcinoma, Metastatic, Urinary Bladder 1 (2%)
Intestine Small, Jejunum (60) (43) (72) (58)
Adenocarcinoma, Cystic, Mucinous 1 (2%) 1 (1%) 1 (2%)
Liver (60) (44) (75) (60)
Carcinoma, Multiple, Metastatic, Uterus 1 (1%)
Carcinoma, Metastatic, Urinary Bladder 1 (2%)
Carcinoma, Metastatic, Uterus 1 (2%)
Hepatocellular Carcinoma 1 (2%)
Neoplastic Nodule 1 (2%)
Neoplastic Nodule, Multiple 2 (3%)
Mesentery (6) (1) (8) (7)
Carcinoma, Multiple, Metastatic, Urinary
Bladder 1 (14%)
Carcinoma, Multiple, Metastatic, Uterus 1 (13%)
Sarcoma Stromal, Metastatic, Uterus 1 (13%) 1 (14%)
Pancreas (60) (43) (75) (59)
Carcinoma, Metastatic, Urinary Bladder 1 (2%)
Pharynx (1) (1) (6) (2)
Palate, Squamous Cell Carcinoma 1 (17%)
Palate, Squamous Cell Papilloma 1 (100%) 3 (50%) 1 (50%)
Salivary Glands (59) (44) (75) (59)
Page 2
NTP Experiment-Test: 05172-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 09/18/94
Route: DOSED WATER Time: 06:28:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 80 PPM 170 PPM 330 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont
Schwannoma Malignant 1 (1%)
Bilateral, Carcinosarcoma 1 (2%)
Stomach, Forestomach (60) (44) (74) (58)
Stomach, Glandular (60) (44) (75) (59)
Tongue (1) (2) (5) (4)
Squamous Cell Carcinoma 2 (40%) 2 (50%)
Squamous Cell Papilloma 1 (100%) 2 (100%) 2 (50%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (45) (75) (60)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (60) (45) (75) (60)
Adrenal Gland, Medulla (60) (45) (74) (59)
Pheochromocytoma Benign 5 (8%) 1 (2%) 1 (1%)
Pituitary Gland (60) (45) (75) (60)
Adenoma 1 (2%)
Pars Distalis, Adenoma 14 (23%) 9 (20%) 5 (7%) 8 (13%)
Pars Distalis, Carcinoma 2 (3%)
Thyroid Gland (60) (44) (75) (59)
C-Cell, Adenoma 4 (7%) 1 (2%) 2 (3%) 1 (2%)
C-Cell, Carcinoma 1 (2%) 1 (1%)
Follicular Cell, Adenoma 1 (1%) 1 (2%)
Follicular Cell, Carcinoma 2 (3%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1)
Carcinoma, Metastatic, Uterus 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (58) (44) (74) (55)
Adenoma 4 (7%) 13 (30%) 12 (16%) 13 (24%)
Carcinoma 2 (3%) 12 (27%) 27 (36%) 26 (47%)
Carcinoma, Metastatic, Clitoral Gland 1 (2%)
Bilateral, Adenoma 1 (2%) 2 (5%) 1 (1%) 3 (5%)
Bilateral, Carcinoma 5 (11%) 14 (19%) 4 (7%)
Ovary (60) (45) (75) (58)
Carcinoma, Metastatic, Urinary Bladder 1 (2%)
Uterus (60) (45) (75) (59)
Page 3
NTP Experiment-Test: 05172-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 09/18/94
Route: DOSED WATER Time: 06:28:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 80 PPM 170 PPM 330 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont
Adenoma 3 (7%) 2 (3%)
Carcinoma 1 (1%)
Deciduoma Benign 1 (2%)
Polyp Stromal 5 (8%) 5 (11%) 6 (8%) 5 (8%)
Polyp Stromal, Multiple 1 (2%) 3 (7%) 1 (1%)
Sarcoma Stromal 1 (2%) 1 (2%) 2 (3%) 1 (2%)
Cervix, Adenoma, Papillary 1 (1%)
Cervix, Carcinoma 1 (2%)
Cervix, Sarcoma Stromal, Metastatic, Uterus 1 (2%)
Vagina (1) (1)
Mucosa, Polyp 1 (100%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (45) (75) (60)
Lymph Node (60) (45) (75) (60)
Renal, Carcinoma, Metastatic, Uterus 1 (1%)
Lymph Node, Mandibular (59) (44) (74) (59)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%)
Axillary, Renal, Carcinoma, Metastatic 1 (1%)
Lymph Node, Mesenteric (60) (44) (75) (58)
Spleen (60) (44) (75) (60)
Thymus (53) (41) (68) (54)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (59) (43) (75) (59)
Adenocarcinoma 1 (2%) 2 (5%) 13 (17%) 18 (31%)
Adenocarcinoma, Multiple 1 (1%) 2 (3%)
Adenoma 1 (2%) 2 (3%)
Fibroadenoma 12 (20%) 9 (21%) 8 (11%) 4 (7%)
Fibroadenoma, Multiple 2 (3%) 2 (5%) 1 (1%)
Mixed Tumor Malignant 1 (2%)
Skin (60) (45) (75) (60)
Basal Cell Adenoma 3 (7%) 3 (4%) 2 (3%)
Basal Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 2 (3%)
Squamous Cell Papilloma, Multiple 1 (1%)
Subcutaneous Tissue, Carcinoma, Metastatic 1 (1%)
Subcutaneous Tissue, Fibroma 1 (2%)
Subcutaneous Tissue, Squamous Cell Carcinoma,
Metastatic, Pharynx 1 (1%)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 05172-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 09/18/94
Route: DOSED WATER Time: 06:28:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 80 PPM 170 PPM 330 PPM
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (2) (5) (8) (4)
Cranium, Carcinoma, Metastatic, Zymbal's
Gland 1 (20%)
Skeletal Muscle (1) (1)
Diaphragm, Carcinoma, Metastatic, Urinary
Bladder 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (45) (75) (60)
Cerebellum, Astrocytoma Malignant 1 (1%)
Cerebrum, Astrocytoma Malignant 1 (2%)
Cerebrum, Carcinoma, Metastatic, Pituitary
Gland 1 (2%)
Meninges, Cerebrum, Nerve, Carcinoma,
Metastatic, Zymbal's Gland 1 (1%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (45) (75) (60)
Adenocarcinoma, Multiple, Metastatic,
Mammary Gland 1 (1%)
Alveolar/Bronchiolar Adenoma 1 (2%) 1 (1%) 1 (2%)
Carcinoma, Multiple, Metastatic, Uterus 1 (1%)
Carcinoma, Multiple, Metastatic, Zymbal's
Gland 1 (1%)
Carcinoma, Metastatic, Clitoral Gland 1 (1%)
Carcinoma, Metastatic, Uncertain Primary Site 1 (2%)
Carcinoma, Metastatic, Urinary Bladder 1 (2%)
Carcinoma, Metastatic, Metastatic 1 (1%)
Mixed Tumor Malignant, Multiple, Metastatic,
Mammary Gland 1 (2%)
Squamous Cell Carcinoma, Metastatic, Pharynx 1 (1%)
Mediastinum, Sarcoma 1 (1%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (60) (45) (75) (60)
Adenoma 3 (7%) 4 (5%) 3 (5%)
Carcinoma 1 (2%) 10 (22%) 17 (23%) 10 (17%)
Bilateral, Carcinoma 3 (5%)
____________________________________________________________________________________________________________________________________
Page 5
NTP Experiment-Test: 05172-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 09/18/94
Route: DOSED WATER Time: 06:28:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 80 PPM 170 PPM 330 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (45) (75) (60)
Lipoma 2 (3%)
Renal Tubule, Adenoma 1 (2%)
Renal Tubule, Carcinoma, Metastatic, Urinary
Bladder 1 (2%)
Transitional Epithelium, Carcinoma 1 (2%)
Ureter (2) (2) (1)
Carcinoma, Metastatic, Urinary Bladder 1 (100%)
Urinary Bladder (60) (45) (75) (59)
Sarcoma Stromal, Metastatic, Uterus 1 (2%)
Transitional Epithelium, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(60) *(45) *(75) *(60)
Leukemia Mononuclear 21 (35%) 15 (33%) 12 (16%) 4 (7%)
Lymphoma Malignant Lymphocytic 1 (1%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 6
NTP Experiment-Test: 05172-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 09/18/94
Route: DOSED WATER Time: 06:28:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 80 PPM 170 PPM 330 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 48 42 73 57
Total Primary Neoplasms 84 113 151 132
Total Animals with Benign Neoplasms 35 30 32 34
Total Benign Neoplasms 53 61 55 54
Total Animals with Malignant Neoplasms 27 32 68 56
Total Malignant Neoplasms 31 52 96 78
Total Animals with Metastatic Neoplasms 1 3 7 4
Total Metastatic Neoplasm 1 4 16 14
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 7
NTP Experiment-Test: 05172-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 09/18/94
Route: DOSED WATER Time: 06:28:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 80 PPM 170 PPM 330 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 70 45 75 70
Scheduled Sacrifice 10 10
Early Deaths
Dead 9 9 25 14
Moribund 7 28 50 46
Survivors
Terminal Sacrifice 44 8
Animals Examined Microscopically 60 45 75 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (60) (42) (72) (58)
Adenocarcinoma, Cystic, Mucinous 1 (2%)
Intestine Large, Colon (60) (43) (73) (58)
Adenocarcinoma 2 (3%)
Ascending Colon, Polyp Adenomatous 1 (2%)
Descending Colon, Adenocarcinoma 2 (3%) 2 (3%)
Descending Colon, Polyp Adenomatous 3 (4%) 4 (7%)
Descending Colon, Polyp Adenomatous, Multiple 1 (1%)
Intestine Large, Rectum (59) (42) (73) (58)
Adenocarcinoma 1 (2%)
Polyp Adenomatous 1 (2%)
Intestine Small, Duodenum (60) (42) (70) (55)
Adenocarcinoma 1 (1%)
Adenocarcinoma, Cystic, Mucinous 2 (5%) 1 (1%)
Intestine Small, Ileum (59) (42) (69) (57)
Adenocarcinoma 1 (2%)
Intestine Small, Jejunum (59) (41) (69) (56)
Adenocarcinoma 1 (1%) 1 (2%)
Adenocarcinoma, Cystic, Mucinous 2 (5%) 4 (6%) 3 (5%)
Liver (60) (45) (74) (60)
Hepatocellular Carcinoma 1 (2%) 1 (2%) 2 (3%)
Neoplastic Nodule 3 (7%) 7 (9%) 4 (7%)
Neoplastic Nodule, Multiple 2 (3%)
Mesentery (22) (9) (28) (11)
Sarcoma 1 (5%)
Schwannoma Malignant 2 (7%)
Pancreas (60) (44) (75) (60)
Adenocarcinoma, Multiple, Metastatic,
Intestine Small 1 (2%)
Acinus, Adenoma 2 (5%) 1 (2%)
Pharynx (1) (4) (7) (7)
Page 8
NTP Experiment-Test: 05172-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 09/18/94
Route: DOSED WATER Time: 06:28:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 80 PPM 170 PPM 330 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont
Carcinoma, Metastatic, Zymbal's Gland 1 (14%)
Mucosa, Carcinoma, Metastatic, Skin 1 (14%)
Palate, Carcinoma, Metastatic, Zymbal's Gland 1 (14%)
Palate, Squamous Cell Carcinoma 1 (14%)
Palate, Squamous Cell Papilloma 4 (100%) 5 (71%) 3 (43%)
Salivary Glands (60) (44) (75) (60)
Schwannoma Malignant 2 (5%)
Stomach, Forestomach (59) (44) (73) (57)
Leiomyosarcoma 1 (1%)
Tongue (2) (4) (6) (10)
Squamous Cell Carcinoma 1 (25%) 1 (10%)
Squamous Cell Papilloma 1 (50%) 3 (75%) 5 (83%) 7 (70%)
Parenchyma, Carcinoma 1 (50%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (44) (75) (60)
Fibrous Histiocytoma, Metastatic, Skin 1 (1%)
Schwannoma Benign 1 (1%)
Schwannoma Malignant 1 (1%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (60) (44) (74) (60)
Adrenal Gland, Cortex (60) (44) (74) (60)
Adrenal Gland, Medulla (60) (44) (74) (60)
Pheochromocytoma Malignant 2 (3%) 1 (2%) 3 (4%)
Pheochromocytoma Benign 12 (20%) 10 (23%) 16 (22%) 5 (8%)
Bilateral, Pheochromocytoma Benign 2 (3%) 7 (16%) 7 (9%) 4 (7%)
Islets, Pancreatic (60) (44) (75) (60)
Adenoma 1 (2%)
Carcinoma 1 (2%)
Pituitary Gland (58) (43) (74) (59)
Schwannoma Malignant, Metastatic, Eye 1 (2%)
Pars Distalis, Adenoma 2 (3%) 1 (2%) 3 (5%)
Thyroid Gland (60) (44) (74) (60)
C-Cell, Adenoma 6 (10%) 6 (14%) 5 (7%) 1 (2%)
C-Cell, Carcinoma 1 (2%) 2 (3%) 1 (2%)
Follicular Cell, Adenoma 1 (2%)
Follicular Cell, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
Page 9
NTP Experiment-Test: 05172-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 09/18/94
Route: DOSED WATER Time: 06:28:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 80 PPM 170 PPM 330 PPM
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (60) (45) (75) (59)
Preputial Gland (60) (43) (73) (59)
Adenoma 13 (22%) 4 (9%) 17 (23%) 11 (19%)
Carcinoma 2 (3%) 5 (12%) 12 (16%) 17 (29%)
Bilateral, Adenoma 1 (2%) 2 (5%) 2 (3%) 1 (2%)
Bilateral, Carcinoma 1 (2%) 3 (4%) 2 (3%)
Prostate (60) (44) (75) (60)
Adenoma 1 (1%)
Seminal Vesicle (58) (42) (58) (44)
Adenocarcinoma, Multiple, Metastatic,
Intestine Small 1 (2%)
Adenoma 1 (2%)
Testes (60) (45) (75) (59)
Bilateral, Interstitial Cell, Adenoma 49 (82%) 35 (78%) 51 (68%) 24 (41%)
Interstitial Cell, Adenoma 8 (13%) 4 (9%) 17 (23%) 18 (31%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (43) (74) (60)
Lymph Node (60) (43) (75) (58)
Axillary, Mediastinal, Basal Cell Carcinoma,
Metastatic, Skin 1 (2%)
Deep Cervical, Carcinoma, Metastatic,
Thyroid Gland 1 (2%)
Inguinal, Carcinoma, Metastatic 1 (2%)
Inguinal, Iliac, Carcinoma, Metastatic,
Preputial Gland 1 (2%)
Mediastinal, Fibrous Histiocytoma,
Metastatic, Skin 1 (1%)
Lymph Node, Mandibular (60) (43) (74) (58)
Squamous Cell Carcinoma, Metastatic, Skin 1 (2%)
Lymph Node, Mesenteric (59) (42) (73) (56)
Mediastinal, Pancreatic, Adenocarcinoma,
Metastatic, Intestine Small 1 (2%)
Spleen (60) (42) (74) (59)
Basal Cell Carcinoma, Metastatic, Skin 1 (2%)
Hemangiosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
Page 10
NTP Experiment-Test: 05172-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 09/18/94
Route: DOSED WATER Time: 06:28:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 80 PPM 170 PPM 330 PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (56) (42) (68) (56)
Fibroadenoma 1 (2%) 2 (3%)
Skin (60) (45) (75) (60)
Basal Cell Adenoma 1 (2%) 15 (33%) 12 (16%) 10 (17%)
Basal Cell Adenoma, Multiple 16 (36%) 35 (47%) 25 (42%)
Basal Cell Carcinoma 1 (2%) 3 (7%) 14 (19%) 13 (22%)
Basal Cell Carcinoma, Multiple 1 (2%) 4 (5%) 4 (7%)
Keratoacanthoma 1 (2%) 5 (11%) 7 (9%) 1 (2%)
Squamous Cell Carcinoma 8 (18%) 15 (20%) 15 (25%)
Squamous Cell Carcinoma, Multiple 1 (2%) 9 (12%) 6 (10%)
Squamous Cell Papilloma 3 (7%) 7 (9%) 3 (5%)
Squamous Cell Papilloma, Multiple 2 (4%) 2 (3%)
Sebaceous Gland, Adenoma 2 (4%) 2 (3%) 1 (2%)
Sebaceous Gland, Carcinoma 1 (1%) 1 (2%)
Subcutaneous Tissue, Carcinoma, Metastatic 1 (2%)
Subcutaneous Tissue, Fibroma 4 (9%) 4 (5%) 1 (2%)
Subcutaneous Tissue, Fibroma, Multiple 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%)
Subcutaneous Tissue, Fibrous Histiocytoma 1 (1%)
Subcutaneous Tissue, Neurofibroma 2 (4%) 2 (3%) 2 (3%)
Subcutaneous Tissue, Sarcoma 2 (3%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (3) (1) (6)
Chordoma 1 (33%)
Cranium, Carcinoma, Metastatic, Zymbal's
Gland 1 (33%) 5 (83%)
Cranium, Squamous Cell Carcinoma, Metastatic 1 (17%)
Cranium, Squamous Cell Carcinoma, Metastatic,
Skin 1 (33%)
Skeletal Muscle (3) (1)
Abdominal, Schwannoma Malignant, Metastatic,
Mesentery 2 (67%)
Cervical, Carcinoma, Metastatic, Zymbal's
Gland 1 (100%)
Thoracic, Fibrous Histiocytoma, Metastatic,
Skin 1 (33%)
____________________________________________________________________________________________________________________________________
Page 11
NTP Experiment-Test: 05172-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 09/18/94
Route: DOSED WATER Time: 06:28:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 80 PPM 170 PPM 330 PPM
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (44) (75) (60)
Astrocytoma Malignant 1 (1%)
Cerebellum, Astrocytoma Malignant 1 (2%)
Cerebellum, Cerebrum, Astrocytoma Malignant 1 (1%)
Cerebrum, Astrocytoma Malignant 1 (2%) 1 (1%) 1 (2%)
Meninges, Cerebrum, Perivascular, Squamous
Cell Carcinoma, Metastatic, Skin 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (44) (75) (60)
Adenocarcinoma, Multiple, Metastatic,
Intestine Small 1 (2%)
Alveolar/Bronchiolar Adenoma 2 (3%) 1 (2%)
Basal Cell Carcinoma, Multiple, Metastatic,
Skin 1 (2%) 1 (2%)
Carcinoma, Multiple, Metastatic, Preputial
Gland 1 (2%)
Carcinoma, Multiple, Metastatic, Zymbal's
Gland 1 (2%) 2 (3%)
Carcinoma, Metastatic, Preputial Gland 1 (1%)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%) 1 (1%) 1 (2%)
Fibrosarcoma, Multiple, Metastatic, Skin 1 (2%)
Fibrous Histiocytoma, Metastatic, Skin 1 (1%)
Squamous Cell Carcinoma, Multiple,
Metastatic, Skin 1 (2%) 1 (2%)
Squamous Cell Carcinoma, Metastatic, Skin 2 (3%)
Nose (60) (44) (74) (60)
Adenoma 1 (1%)
Squamous Cell Carcinoma, Metastatic, Skin 1 (2%)
Submucosa, Schwannoma Malignant, Metastatic,
Eye 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (4) (3) (3) (2)
Choroid, Conjunctiva, Retrobulbar, Squamous
Cell Carcinoma, Metastatic, Skin 1 (33%)
Optic Nerve, Schwannoma Malignant 1 (50%)
Zymbal's Gland (59) (45) (75) (60)
Adenoma 3 (7%) 11 (15%) 9 (15%)
Carcinoma 7 (16%) 13 (17%) 20 (33%)
Bilateral, Adenoma 1 (2%)
Bilateral, Carcinoma 1 (1%) 1 (2%)
Page 12
NTP Experiment-Test: 05172-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 09/18/94
Route: DOSED WATER Time: 06:28:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 80 PPM 170 PPM 330 PPM
____________________________________________________________________________________________________________________________________
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (44) (74) (60)
Adenocarcinoma, Metastatic, Intestine Small 1 (2%)
Urinary Bladder (60) (44) (75) (59)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(60) *(45) *(75) *(60)
Leukemia Mononuclear 19 (32%) 17 (38%) 17 (23%) 4 (7%)
Lymphoma Malignant Histiocytic 1 (1%)
Mesothelioma Benign 2 (3%)
Mesothelioma Malignant 2 (3%) 1 (2%) 7 (9%) 4 (7%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 13
NTP Experiment-Test: 05172-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 09/18/94
Route: DOSED WATER Time: 06:28:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 80 PPM 170 PPM 330 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 59 45 75 60
Total Primary Neoplasms 129 194 344 254
Total Animals with Benign Neoplasms 57 43 70 53
Total Benign Neoplasms 98 135 223 149
Total Animals with Malignant Neoplasms 27 36 66 59
Total Malignant Neoplasms 31 59 121 105
Total Animals with Metastatic Neoplasms 2 6 11 19
Total Metastatic Neoplasm 17 16 36 39
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 14
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------
--multipart-boundary
Content-type: text/plain
Range: bytes 85894-85894/85894
--multipart-boundary--