TDMS Study 05172-01 Pathology Tables
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
Facility: Hazleton Laboratories America, Inc.
Chemical CAS #: 20325400
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
_____________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 4| 0| 4| 4| 4| 2| 2| 4| 4| 4| 4| 4|
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8| 8| 8| 8| 2| 8| 8| 8| 4| 4| 8| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Angiectasis | |
Basophilic Focus | 2 2 3 3 3 1 1 2 3 1 2 2 2|
Clear Cell Focus | |
Degeneration, Cystic | 1 |
Eosinophilic Focus | 2 3 |
Fatty Change | |
Granuloma | 2 2 2 2 |
Hematopoietic Cell Proliferation | 1 |
Hepatodiaphragmatic Nodule | X |
Hepatodiaphragmatic Nodule, Multiple | |
Regeneration, Diffuse | 2 |
Vacuolization Cytoplasmic, Focal | |
Vacuolization Cytoplasmic, Multifocal| |
Bile Duct, Hyperplasia | 2 |
Centrilobular, Degeneration | |
Centrilobular, Necrosis | 2 |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + +|
Atrophy | 2 |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + +|
Atrophy | 3 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 2 2 2 1 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
_____________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 4| 0| 4| 4| 4| 2| 2| 4| 4| 4| 4| 4|
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8| 8| 8| 8| 2| 8| 8| 8| 4| 4| 8| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + +|
Degeneration, Focal | |
Hyperplasia, Focal | 2 2 |
Hypertrophy, Focal | |
Vacuolization Cytoplasmic, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 1 2 |
Hyperplasia, Multifocal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | X X X X X X |
Pars Distalis, Hemorrhage | |
Pars Distalis, Hyperplasia, Diffuse | |
Pars Distalis, Hyperplasia, Focal | 2 |
Pars Distalis, Hyperplasia | |
Pars Distalis, Hyperplasia, | |
Multifocal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | 2 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + +|
Atrophy | 3 |
Ectasia | 3 |
Hyperplasia, Focal | 3 |
Hyperplasia, Focal, Squamous | |
Inflammation, Chronic | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + +|
Cyst | X |
Bilateral, Cyst | |
Germinal Epithelium, Hyperplasia, | |
Focal, Papillary | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + +|
Cyst | |
Hydrometra | 3 |
Cervix, Cyst | |
Cervix, Fibrosis | 3 3 |
Cervix, Prolapse | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
_____________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 4| 0| 4| 4| 4| 2| 2| 4| 4| 4| 4| 4|
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8| 8| 8| 8| 2| 8| 8| 8| 4| 4| 8| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Endometrium, Cyst | |
__________________________________________________________________________|
Vagina | |
Thrombosis, Multiple | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + +|
Hyperplasia | |
Hypoplasia | 3 |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + +|
Mediastinal, Hyperplasia, Lymphoid | 3 |
Mediastinal, Pigmentation | |
Pancreatic, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + +|
Hyperplasia, Reticulum Cell | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 |
Pigmentation | 2 3 |
__________________________________________________________________________|
Thymus | + + M + + + + M + + + + M + +|
Epithelial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + +|
Galactocele | |
Duct, Ectasia | 3 3 3 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + |
Sternum, Osteopetrosis | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + +|
Cerebrum, Compression | X X X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + +|
Hemorrhage, Focal | |
Hyperplasia, Lymphoid | 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Alveolar Epithelium, Hyperplasia, | |
Focal | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
_____________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 4| 0| 4| 4| 4| 2| 2| 4| 4| 4| 4| 4|
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8| 8| 8| 8| 2| 8| 8| 8| 4| 4| 8| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Acute | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + + + +|
Ectasia | 1 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + +|
Infarct, Chronic | |
Nephropathy, Chronic | 3 2 1 2 3 2 4 1 2 2 1 2|
Renal Tubule, Pigmentation | 1 |
__________________________________________________________________________|
Ureter | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5|
DAY ON TEST | 4| 4| 4| 3| 7| 4| 4| 4| 0| 2| 4| 4| 4| 4| 7| 4| 4| 4| 4| 9| 4| 4| 4| 5| 4|
| 8| 8| 8| 1| 4| 8| 8| 8| 2| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 8| 8| 8| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Angiectasis | 1 |
Basophilic Focus | 3 2 2 2 1 2 1 2 1 1 1 2 2 1 2 2 2 1 2|
Clear Cell Focus | 1 2 1 2 |
Degeneration, Cystic | |
Eosinophilic Focus | 2 1 |
Fatty Change | |
Granuloma | 2 2 2 1 |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X |
Hepatodiaphragmatic Nodule, Multiple | |
Regeneration, Diffuse | 2 2 2|
Vacuolization Cytoplasmic, Focal | 2 |
Vacuolization Cytoplasmic, Multifocal| 2 2 |
Bile Duct, Hyperplasia | |
Centrilobular, Degeneration | 1 |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Necrosis | 3 3 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + M + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 2 1 1 2 1 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5|
DAY ON TEST | 4| 4| 4| 3| 7| 4| 4| 4| 0| 2| 4| 4| 4| 4| 7| 4| 4| 4| 4| 9| 4| 4| 4| 5| 4|
| 8| 8| 8| 1| 4| 8| 8| 8| 2| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 8| 8| 8| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Focal | |
Hyperplasia, Focal | 3 3 |
Hypertrophy, Focal | 2 |
Vacuolization Cytoplasmic, Focal | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 2 |
Hyperplasia, Multifocal | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + M M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 2 3 |
Pars Distalis, Cyst | 4 X X X |
Pars Distalis, Hemorrhage | 3 |
Pars Distalis, Hyperplasia, Diffuse | 3 |
Pars Distalis, Hyperplasia, Focal | 2 2 2 2 |
Pars Distalis, Hyperplasia | |
Pars Distalis, Hyperplasia, | |
Multifocal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Ectasia | 3 3 3 |
Hyperplasia, Focal | 3 |
Hyperplasia, Focal, Squamous | |
Inflammation, Chronic | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X |
Bilateral, Cyst | X |
Germinal Epithelium, Hyperplasia, | |
Focal, Papillary | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hydrometra | 2 |
Cervix, Cyst | X |
Cervix, Fibrosis | 2 3 2 2 |
Cervix, Prolapse | 4 |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5|
DAY ON TEST | 4| 4| 4| 3| 7| 4| 4| 4| 0| 2| 4| 4| 4| 4| 7| 4| 4| 4| 4| 9| 4| 4| 4| 5| 4|
| 8| 8| 8| 1| 4| 8| 8| 8| 2| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 8| 8| 8| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Endometrium, Cyst | |
__________________________________________________________________________|
Vagina | + |
Thrombosis, Multiple | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2|
Hypoplasia | |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Hyperplasia, Lymphoid | |
Mediastinal, Pigmentation | |
Pancreatic, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Reticulum Cell | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Pigmentation | 3 |
__________________________________________________________________________|
Thymus | + + + + + + M + + + + M + + + + + + + + + + + + +|
Epithelial Cell, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M + + + + + + + + + + + + + + + + + + + + +|
Galactocele | X X |
Duct, Ectasia | 3 3 3 3 2 3 3 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + |
Sternum, Osteopetrosis | 4 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebrum, Compression | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | |
Hyperplasia, Lymphoid | 2 2 2 3 2 2 2 2 2 3 2 3 2 2 2 2 2 2 2 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 1 1 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5|
DAY ON TEST | 4| 4| 4| 3| 7| 4| 4| 4| 0| 2| 4| 4| 4| 4| 7| 4| 4| 4| 4| 9| 4| 4| 4| 5| 4|
| 8| 8| 8| 1| 4| 8| 8| 8| 2| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 8| 8| 8| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Acute | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct, Chronic | 3 |
Nephropathy, Chronic | 2 1 1 2 1 1 1 3 2 1 2 2 2 2 2 1 1 2 2 3 |
Renal Tubule, Pigmentation | 4 |
__________________________________________________________________________|
Ureter | + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
DAY ON TEST | 5| 5| 5| 5| 3| 5| 5| 5| 5| 9| 5| 4| 4| 1| 0| 5| 5| 4| 5| 5| | |
| 1| 1| 1| 1| 2| 1| 1| 1| 1| 0| 1| 4| 8| 8| 0| 1| 1| 8| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
CONTROL | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 60 |
Angiectasis, Focal | 3 | 1 3.0|
Angiectasis | | 1 1.0|
Basophilic Focus | 2 1 2 1 2 2 1 2 3 2 2 2 | 44 1.8|
Clear Cell Focus | 1 1 1 | 7 1.3|
Degeneration, Cystic | | 1 1.0|
Eosinophilic Focus | 1 | 5 1.8|
Fatty Change | 3 | 1 3.0|
Granuloma | 4 2 | 10 2.1|
Hematopoietic Cell Proliferation | | 1 1.0|
Hepatodiaphragmatic Nodule | X X X | 5 |
Hepatodiaphragmatic Nodule, Multiple | X | 1 |
Regeneration, Diffuse | 2 2 | 6 2.0|
Vacuolization Cytoplasmic, Focal | | 1 2.0|
Vacuolization Cytoplasmic, Multifocal| | 2 2.0|
Bile Duct, Hyperplasia | | 1 2.0|
Centrilobular, Degeneration | | 1 1.0|
Centrilobular, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + | 6 |
Fat, Necrosis | 3 3 | 6 2.8|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 60 |
Atrophy | 2 | 4 2.0|
__________________________________________________________________________|____________|
Pharynx | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 59 |
Atrophy | | 1 3.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Tongue | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
DAY ON TEST | 5| 5| 5| 5| 3| 5| 5| 5| 5| 9| 5| 4| 4| 1| 0| 5| 5| 4| 5| 5| | |
| 1| 1| 1| 1| 2| 1| 1| 1| 1| 0| 1| 4| 8| 8| 0| 1| 1| 8| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
CONTROL | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 60 |
Cardiomyopathy, Chronic | 2 1 1 2 2 1 1 | 25 1.6|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + | 60 |
Degeneration, Focal | 3 | 1 3.0|
Hyperplasia, Focal | 1 | 5 2.2|
Hypertrophy, Focal | 2 | 2 2.0|
Vacuolization Cytoplasmic, Focal | 2 | 2 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + | 60 |
Hyperplasia, Focal | | 5 1.6|
Hyperplasia, Multifocal | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 60 |
Pars Distalis, Angiectasis | | 3 2.3|
Pars Distalis, Cyst | X X X X | 14 4.0|
Pars Distalis, Hemorrhage | | 1 3.0|
Pars Distalis, Hyperplasia, Diffuse | | 1 3.0|
Pars Distalis, Hyperplasia, Focal | | 5 2.0|
Pars Distalis, Hyperplasia | 2 | 1 2.0|
Pars Distalis, Hyperplasia, | | |
Multifocal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 60 |
C-Cell, Hyperplasia, Focal | 2 3 | 6 1.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + M M + + + + + + | 58 |
Atrophy | 3 | 3 3.0|
Ectasia | 4 3 3 2 2 3 3 4 3 3 3 | 15 3.0|
Hyperplasia, Focal | 3 | 3 3.0|
Hyperplasia, Focal, Squamous | 3 | 1 3.0|
Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
DAY ON TEST | 5| 5| 5| 5| 3| 5| 5| 5| 5| 9| 5| 4| 4| 1| 0| 5| 5| 4| 5| 5| | |
| 1| 1| 1| 1| 2| 1| 1| 1| 1| 0| 1| 4| 8| 8| 0| 1| 1| 8| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
CONTROL | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Cyst | X | 6 |
Bilateral, Cyst | | 1 |
Germinal Epithelium, Hyperplasia, | | |
Focal, Papillary | | 1 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + | 60 |
Cyst | | 1 |
Hydrometra | 3 | 3 2.7|
Cervix, Cyst | X | 2 |
Cervix, Fibrosis | 2 2 2 3 2 | 11 2.4|
Cervix, Prolapse | | 1 4.0|
Endometrium, Cyst | X | 1 |
__________________________________________________________________________|____________|
Vagina | | 1 |
Thrombosis, Multiple | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 60 |
Hyperplasia | 2 2 2 | 5 2.0|
Hypoplasia | 3 | 2 3.0|
Myelofibrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + | 60 |
Mediastinal, Hyperplasia, Lymphoid | | 1 3.0|
Mediastinal, Pigmentation | 3 | 1 3.0|
Pancreatic, Pigmentation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | 59 |
Hyperplasia, Lymphoid | | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | 60 |
Hyperplasia, Reticulum Cell | | 2 2.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 60 |
Hematopoietic Cell Proliferation | 2 | 3 2.0|
Pigmentation | 2 3 | 5 2.6|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + M + + + + + + + + + M | 53 |
Epithelial Cell, Hyperplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + | 59 |
Galactocele | | 2 |
Duct, Ectasia | 3 3 3 3 | 16 2.9|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
DAY ON TEST | 5| 5| 5| 5| 3| 5| 5| 5| 5| 9| 5| 4| 4| 1| 0| 5| 5| 4| 5| 5| | |
| 1| 1| 1| 1| 2| 1| 1| 1| 1| 0| 1| 4| 8| 8| 0| 1| 1| 8| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
CONTROL | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone | | 2 |
Sternum, Osteopetrosis | | 2 3.5|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 60 |
Cerebrum, Compression | X X X X X | 8 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 60 |
Hemorrhage, Focal | 1 | 1 1.0|
Hyperplasia, Lymphoid | 2 2 2 2 2 2 2 2 2 2 2 2 | 45 2.1|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 1 3 | 5 1.6|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 60 |
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + | 60 |
Ectasia | 2 2 2 2 | 12 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 60 |
Infarct, Chronic | | 1 3.0|
Nephropathy, Chronic | 2 2 2 3 1 2 2 1 2 3 2 2 2 2 1 1 1 2 | 50 1.8|
Renal Tubule, Pigmentation | | 2 2.5|
__________________________________________________________________________|____________|
Ureter | | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 60 |
Hemorrhage | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
_____________________________________________________________________________________________________________________
| 6| 6| 5| 5| 4| 6| 6| 6| 5| 4| 6| 6| 6| 5| 4| 6| 6| 6| 5| 4| 6| 6| 6| 6| 5|
DAY ON TEST | 4| 4| 6| 2| 8| 4| 4| 1| 9| 8| 4| 4| 1| 8| 8| 4| 1| 1| 1| 2| 4| 4| 4| 0| 7|
| 8| 8| 4| 0| 5| 8| 8| 8| 9| 5| 4| 8| 8| 8| 3| 8| 8| 6| 2| 4| 8| 8| 8| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
80 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + A|
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + A|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + M + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + A|
Angiectasis, Focal | 3 |
Basophilic Focus | 2 2 1 2 2 2 2 2 1 2 2 1 1 2 2 2 2 2 2 |
Clear Cell Focus | 1 2 1 2 2 2 2 |
Degeneration, Cystic | 1 |
Eosinophilic Focus | 2 1 2 |
Fatty Change | 3 |
Granuloma | |
Hematopoietic Cell Proliferation | 2 2 2 2 1 1 1 3 1 |
Hepatodiaphragmatic Nodule | X X X |
Necrosis, Multifocal | |
Pigmentation | 1 |
Regeneration, Diffuse | 2 |
Regeneration, Multifocal | |
Vacuolization Cytoplasmic, Focal | 2 |
Bile Duct, Hyperplasia | 2 |
Centrilobular, Degeneration, Diffuse | 2 |
Centrilobular, Degeneration | |
Centrilobular, Necrosis, Diffuse | 2 |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + A|
Atrophy | 2 2 3 |
__________________________________________________________________________|
Pharynx | + |
Palate, Hyperkeratosis, Focal | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 4 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion, Focal | |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
_____________________________________________________________________________________________________________________
| 6| 6| 5| 5| 4| 6| 6| 6| 5| 4| 6| 6| 6| 5| 4| 6| 6| 6| 5| 4| 6| 6| 6| 6| 5|
DAY ON TEST | 4| 4| 6| 2| 8| 4| 4| 1| 9| 8| 4| 4| 1| 8| 8| 4| 1| 1| 1| 2| 4| 4| 4| 0| 7|
| 8| 8| 4| 0| 5| 8| 8| 8| 9| 5| 4| 8| 8| 8| 3| 8| 8| 6| 2| 4| 8| 8| 8| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
80 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 1 2 2 1 1 1 2 1 1 2 1 |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Focal | |
Hyperplasia, Focal | |
Hypertrophy, Focal | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 4 3 |
Pars Distalis, Cyst | X X X X |
Pars Distalis, Hyperplasia, Diffuse | 3 3 |
Pars Distalis, Hyperplasia, Focal | 2 2 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | 2 1 2 |
C-Cell, Hyperplasia, Multifocal | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 4 3 3 3 2 4 |
Hyperplasia, Focal | 2 2 |
Hyperplasia, Focal, Squamous | 2 |
Hyperplasia, Multifocal | 3 3 |
Hyperplasia, Multifocal, Squamous | |
Inflammation, Acute | |
Necrosis | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 X 3 |
__________________________________________________________________________|
Oviduct | |
Thrombosis | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 3 |
Inflammation, Acute | 3 |
Thrombosis | |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
_____________________________________________________________________________________________________________________
| 6| 6| 5| 5| 4| 6| 6| 6| 5| 4| 6| 6| 6| 5| 4| 6| 6| 6| 5| 4| 6| 6| 6| 6| 5|
DAY ON TEST | 4| 4| 6| 2| 8| 4| 4| 1| 9| 8| 4| 4| 1| 8| 8| 4| 1| 1| 1| 2| 4| 4| 4| 0| 7|
| 8| 8| 4| 0| 5| 8| 8| 8| 9| 5| 4| 8| 8| 8| 3| 8| 8| 6| 2| 4| 8| 8| 8| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
80 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Bilateral, Hydrometra | 3 |
Cervix, Fibrosis | 2 2 |
Endometrium, Cyst | 3 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 2 2 |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Erythrophagocytosis | 2 |
Mediastinal, Infiltration Cellular, | |
Histiocyte | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 4 3 3 |
Hyperplasia, Reticulum Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + M|
Hyperplasia, Reticulum Cell | 3 3 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 4 3 2 3 4 3 3 2 3 3 2 |
Hyperplasia, Reticulum Cell | |
Pigmentation | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + M + + + + M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | |
Duct, Ectasia | 3 3 3 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hair Follicle, Hyperplasia, Basal | |
Cell, Multifocal | |
Subcutaneous Tissue, Abscess, Focal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + |
Sternum, Osteopetrosis | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebrum, Compression | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 2 2 2 2 2 3 3 2 2 2 1 2 2 2 |
Infiltration Cellular, Histiocyte | 2 3 1 |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
_____________________________________________________________________________________________________________________
| 6| 6| 5| 5| 4| 6| 6| 6| 5| 4| 6| 6| 6| 5| 4| 6| 6| 6| 5| 4| 6| 6| 6| 6| 5|
DAY ON TEST | 4| 4| 6| 2| 8| 4| 4| 1| 9| 8| 4| 4| 1| 8| 8| 4| 1| 1| 1| 2| 4| 4| 4| 0| 7|
| 8| 8| 4| 0| 5| 8| 8| 8| 9| 5| 4| 8| 8| 8| 3| 8| 8| 6| 2| 4| 8| 8| 8| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
80 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
Alveolar Epithelium, Hyperplasia, | |
Multifocal | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 2 3 |
Inflammation, Acute | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
Cataract | 3 3 |
Synechia | 4 |
Retina, Degeneration | 4 4 |
__________________________________________________________________________|
Harderian Gland | + + |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 3 3 2 2 2 2 3 2 3 3 2 3 |
Hyperplasia, Focal | 3 |
Hyperplasia, Focal, Squamous | 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct, Chronic | 3 |
Inflammation, Chronic Active | 4 |
Nephropathy, Chronic | 2 1 2 2 2 2 1 2 2 2 1 2 1 2 3 |
Cortex, Cyst | |
Medulla, Inflammation, Acute | 3 |
Renal Tubule, Degeneration, Hyaline | 2 3 |
Renal Tubule, Dilatation | 2 |
Renal Tubule, Vacuolization | |
Cytoplasmic | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 4| 3| 6| 6| 6| 6| 4| 6| 6| 5| 5| 5| 6| 6| 6| 5| 4| | |
DAY ON TEST | 4| 1| 3| 2| 7| 4| 4| 4| 1| 7| 1| 1| 9| 6| 7| 4| 4| 0| 0| 3| | |
| 8| 8| 2| 4| 3| 8| 8| 8| 8| 6| 6| 6| 9| 2| 1| 8| 8| 2| 5| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
80 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + | 44 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 44 |
Parasite Metazoan | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | 44 |
Parasite Metazoan | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 43 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + A + | 43 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + A + | 43 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + A + | 43 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + A + | 43 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 44 |
Angiectasis, Focal | | 1 3.0|
Basophilic Focus | 2 1 2 1 2 3 1 2 1 2 1 2 3 2 1 | 34 1.8|
Clear Cell Focus | 1 2 2 1 | 11 1.6|
Degeneration, Cystic | 1 | 2 1.0|
Eosinophilic Focus | 2 3 3 3 | 7 2.3|
Fatty Change | | 1 3.0|
Granuloma | 1 3 1 | 3 1.7|
Hematopoietic Cell Proliferation | 1 2 1 1 2 2 1 1 1 | 18 1.5|
Hepatodiaphragmatic Nodule | X X X | 6 |
Necrosis, Multifocal | 3 | 1 3.0|
Pigmentation | | 1 1.0|
Regeneration, Diffuse | 2 | 2 2.0|
Regeneration, Multifocal | 3 | 1 3.0|
Vacuolization Cytoplasmic, Focal | | 1 2.0|
Bile Duct, Hyperplasia | | 1 2.0|
Centrilobular, Degeneration, Diffuse | 1 | 2 1.5|
Centrilobular, Degeneration | 4 | 1 4.0|
Centrilobular, Necrosis, Diffuse | | 1 2.0|
Centrilobular, Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 1 |
Fat, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + A + | 43 |
Atrophy | 2 | 4 2.3|
__________________________________________________________________________|____________|
Pharynx | | 1 |
Palate, Hyperkeratosis, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + M + | 44 |
Inflammation, Chronic | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 4| 3| 6| 6| 6| 6| 4| 6| 6| 5| 5| 5| 6| 6| 6| 5| 4| | |
DAY ON TEST | 4| 1| 3| 2| 7| 4| 4| 4| 1| 7| 1| 1| 9| 6| 7| 4| 4| 0| 0| 3| | |
| 8| 8| 2| 4| 3| 8| 8| 8| 8| 6| 6| 6| 9| 2| 1| 8| 8| 2| 5| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
80 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + A + | 44 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + A + | 44 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + A + | 44 |
Erosion, Focal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Tongue | + | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 45 |
Cardiomyopathy, Chronic | 1 1 2 1 2 1 | 17 1.4|
Atrium, Thrombosis | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + | 45 |
Degeneration, Focal | 2 | 1 2.0|
Hyperplasia, Focal | 2 | 1 2.0|
Hypertrophy, Focal | 2 1 | 3 1.7|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + A + | 43 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + + + + + + + + + + + + + M + | 43 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 45 |
Pars Distalis, Angiectasis | 3 3 | 4 3.3|
Pars Distalis, Cyst | X X X X X X | 10 |
Pars Distalis, Hyperplasia, Diffuse | | 2 3.0|
Pars Distalis, Hyperplasia, Focal | 2 | 4 2.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + M + | 44 |
C-Cell, Hyperplasia, Focal | 2 | 4 1.8|
C-Cell, Hyperplasia, Multifocal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + M + + + + + + + + + + + + + + + + | 44 |
Ectasia | 3 3 2 4 3 | 11 3.1|
Hyperplasia, Focal | 2 2 | 4 2.0|
Hyperplasia, Focal, Squamous | 2 | 2 2.0|
Hyperplasia, Multifocal | | 2 3.0|
Hyperplasia, Multifocal, Squamous | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 4| 3| 6| 6| 6| 6| 4| 6| 6| 5| 5| 5| 6| 6| 6| 5| 4| | |
DAY ON TEST | 4| 1| 3| 2| 7| 4| 4| 4| 1| 7| 1| 1| 9| 6| 7| 4| 4| 0| 0| 3| | |
| 8| 8| 2| 4| 3| 8| 8| 8| 8| 6| 6| 6| 9| 2| 1| 8| 8| 2| 5| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
80 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Acute | 3 | 1 3.0|
Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + | 45 |
Cyst | X X X X | 7 2.5|
__________________________________________________________________________|____________|
Oviduct | + | 1 |
Thrombosis | X | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + | 45 |
Hydrometra | | 1 3.0|
Inflammation, Acute | | 1 3.0|
Thrombosis | X | 1 |
Bilateral, Hydrometra | | 1 3.0|
Cervix, Fibrosis | 2 | 3 2.0|
Endometrium, Cyst | | 2 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 45 |
Hyperplasia | 2 2 2 2 | 8 2.1|
Myelofibrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + | 45 |
Mediastinal, Erythrophagocytosis | | 1 2.0|
Mediastinal, Infiltration Cellular, | | |
Histiocyte | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + M + | 44 |
Hyperplasia, Lymphoid | | 3 3.3|
Hyperplasia, Reticulum Cell | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | 44 |
Hyperplasia, Reticulum Cell | | 3 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + A + | 44 |
Hematopoietic Cell Proliferation | 3 4 2 3 2 3 3 3 3 2 | 22 2.9|
Hyperplasia, Reticulum Cell | 3 | 1 3.0|
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + M + + + M + | 41 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + M + | 43 |
Galactocele | X | 1 |
Duct, Ectasia | 3 3 3 | 7 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 45 |
Hair Follicle, Hyperplasia, Basal | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 4| 3| 6| 6| 6| 6| 4| 6| 6| 5| 5| 5| 6| 6| 6| 5| 4| | |
DAY ON TEST | 4| 1| 3| 2| 7| 4| 4| 4| 1| 7| 1| 1| 9| 6| 7| 4| 4| 0| 0| 3| | |
| 8| 8| 2| 4| 3| 8| 8| 8| 8| 6| 6| 6| 9| 2| 1| 8| 8| 2| 5| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
80 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Cell, Multifocal | 2 | 1 2.0|
Subcutaneous Tissue, Abscess, Focal | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + | 5 |
Sternum, Osteopetrosis | 3 2 3 | 4 2.8|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 45 |
Cerebrum, Compression | X | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 45 |
Hyperplasia, Lymphoid | 2 2 1 2 2 2 2 2 3 3 2 2 2 2 2 | 31 2.1|
Infiltration Cellular, Histiocyte | | 3 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Multifocal | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 45 |
Fungus | | 2 2.5|
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 45 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 3 |
Cataract | | 2 3.0|
Synechia | | 1 4.0|
Retina, Degeneration | | 2 4.0|
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + | 45 |
Ectasia | 2 2 2 2 2 2 2 2 | 21 2.3|
Hyperplasia, Focal | 2 | 2 2.5|
Hyperplasia, Focal, Squamous | 1 2 | 3 1.3|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 45 |
Infarct, Chronic | 3 | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 4| 3| 6| 6| 6| 6| 4| 6| 6| 5| 5| 5| 6| 6| 6| 5| 4| | |
DAY ON TEST | 4| 1| 3| 2| 7| 4| 4| 4| 1| 7| 1| 1| 9| 6| 7| 4| 4| 0| 0| 3| | |
| 8| 8| 2| 4| 3| 8| 8| 8| 8| 6| 6| 6| 9| 2| 1| 8| 8| 2| 5| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
80 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | | 1 4.0|
Nephropathy, Chronic | 1 1 1 1 3 3 2 2 1 2 2 2 1 | 28 1.8|
Cortex, Cyst | X | 1 |
Medulla, Inflammation, Acute | | 1 3.0|
Renal Tubule, Degeneration, Hyaline | | 2 2.5|
Renal Tubule, Dilatation | | 1 2.0|
Renal Tubule, Vacuolization | | |
Cytoplasmic | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 45 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
_____________________________________________________________________________________________________________________
| 6| 6| 4| 4| 4| 6| 5| 5| 4| 4| 5| 5| 4| 3| 3| 5| 5| 5| 3| 3| 4| 3| 3| 3| 2|
DAY ON TEST | 4| 1| 8| 7| 2| 4| 6| 5| 0| 0| 5| 9| 5| 5| 0| 7| 6| 0| 7| 7| 0| 7| 5| 3| 8|
| 8| 6| 6| 7| 3| 8| 3| 0| 8| 8| 6| 7| 0| 8| 4| 1| 2| 6| 8| 3| 8| 9| 8| 9| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
170 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
Descending Colon, Hemorrhage, Focal | 3 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X 1 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2 2 2 4 2 2 2 2 2 2 2 2 2 1 1 2 1 1 1|
Clear Cell Focus | 2 1 2 1 1 |
Degeneration, Cystic, Focal | |
Eosinophilic Focus | 2 3 3 2 3 2 2 |
Fatty Change | |
Granuloma | 2 2 2 |
Hematopoietic Cell Proliferation | 3 2 1 2 1 1 2 2 2 1 1 1 1|
Hepatodiaphragmatic Nodule | X X X X |
Hepatodiaphragmatic Nodule, Multiple | |
Necrosis, Coagulative | |
Necrosis, Focal | 3 2 1 |
Necrosis, Multifocal | |
Regeneration, Diffuse | 3 |
Regeneration, Focal | |
Regeneration, Multifocal | |
Vacuolization Cytoplasmic, Diffuse | 2 |
Vacuolization Cytoplasmic, Multifocal| |
Bile Duct, Hyperplasia | 2 |
Centrilobular, Degeneration, Diffuse | 1 1 1 |
Centrilobular, Degeneration | |
Centrilobular, Necrosis, Diffuse | |
Centrilobular, Necrosis | 3 |
__________________________________________________________________________|
Mesentery | + |
Fat, Accessory Spleen | |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 |
__________________________________________________________________________|
Pharynx | + |
Mucosa, Palate, Hyperplasia, Focal | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
_____________________________________________________________________________________________________________________
| 6| 6| 4| 4| 4| 6| 5| 5| 4| 4| 5| 5| 4| 3| 3| 5| 5| 5| 3| 3| 4| 3| 3| 3| 2|
DAY ON TEST | 4| 1| 8| 7| 2| 4| 6| 5| 0| 0| 5| 9| 5| 5| 0| 7| 6| 0| 7| 7| 0| 7| 5| 3| 8|
| 8| 6| 6| 7| 3| 8| 3| 0| 8| 8| 6| 7| 0| 8| 4| 1| 2| 6| 8| 3| 8| 9| 8| 9| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
170 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Atrophy | 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 |
Hyperkeratosis | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion, Focal | |
Erosion, Multifocal | |
Necrosis, Multifocal | |
__________________________________________________________________________|
Tongue | + + |
Hyperplasia, Focal | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 1 1 2 2 1 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Ectasia | |
Hyperplasia, Multifocal | |
Hypertrophy, Focal | 2 |
Hypertrophy, Multifocal | |
Vacuolization Cytoplasmic, Diffuse | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pigmentation | 2 |
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Cyst | X X X X X |
Pars Distalis, Hyperplasia, Focal | 2 2 3 |
Pars Distalis, Hyperplasia, | |
Multifocal | |
Pars Distalis, Necrosis, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
_____________________________________________________________________________________________________________________
| 6| 6| 4| 4| 4| 6| 5| 5| 4| 4| 5| 5| 4| 3| 3| 5| 5| 5| 3| 3| 4| 3| 3| 3| 2|
DAY ON TEST | 4| 1| 8| 7| 2| 4| 6| 5| 0| 0| 5| 9| 5| 5| 0| 7| 6| 0| 7| 7| 0| 7| 5| 3| 8|
| 8| 6| 6| 7| 3| 8| 3| 0| 8| 8| 6| 7| 0| 8| 4| 1| 2| 6| 8| 3| 8| 9| 8| 9| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
170 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Cyst | |
Ectasia | 3 3 3 4 |
Hyperplasia, Focal | 2 2 2 1 |
Hyperplasia, Multifocal, Squamous | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hydrometra | 4 |
Cervix, Fibrosis | |
Endometrium, Cyst | 2 |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Hemorrhage | |
Pancreatic, Pigmentation | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hemorrhage | |
Hyperplasia, Lymphoid | 3 3 |
Hyperplasia, Reticulum Cell | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hemorrhage | 2 |
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Reticulum Cell | 2 2 1 2 2 3 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hematopoietic Cell Proliferation | 4 2 3 3 4 3 4 3 4 3 3 2 3|
Hemorrhage, Focal | |
Infarct | |
Pigmentation | |
__________________________________________________________________________|
Thymus | + + + + M + + M + + + + + + + + + + + + + + + + +|
Atrophy | |
Congestion | 2 |
Hemorrhage, Focal | |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
_____________________________________________________________________________________________________________________
| 6| 6| 4| 4| 4| 6| 5| 5| 4| 4| 5| 5| 4| 3| 3| 5| 5| 5| 3| 3| 4| 3| 3| 3| 2|
DAY ON TEST | 4| 1| 8| 7| 2| 4| 6| 5| 0| 0| 5| 9| 5| 5| 0| 7| 6| 0| 7| 7| 0| 7| 5| 3| 8|
| 8| 6| 6| 7| 3| 8| 3| 0| 8| 8| 6| 7| 0| 8| 4| 1| 2| 6| 8| 3| 8| 9| 8| 9| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
170 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Ectasia | 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + |
Sternum, Osteopetrosis | 3 2 3 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Meninges, Infiltration Cellular, | |
Mononuclear Cell | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 3 2 2 2 3 1 2 2 2 2 2 2 2 2 2 2 2 2 |
Infiltration Cellular, Histiocyte | 1 |
Thrombosis | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 1|
Alveolus, Pigmentation | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Cataract | 4 |
Inflammation, Chronic Active | 4 |
Synechia | |
Cornea, Necrosis | 4 |
Retina, Degeneration | |
__________________________________________________________________________|
Harderian Gland | |
Inflammation, Chronic | |
__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 2 2 1 3 |
Hyperplasia, Focal | 1 1 |
Hyperplasia, Focal, Squamous | |
Hyperplasia, Multifocal | 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
_____________________________________________________________________________________________________________________
| 6| 6| 4| 4| 4| 6| 5| 5| 4| 4| 5| 5| 4| 3| 3| 5| 5| 5| 3| 3| 4| 3| 3| 3| 2|
DAY ON TEST | 4| 1| 8| 7| 2| 4| 6| 5| 0| 0| 5| 9| 5| 5| 0| 7| 6| 0| 7| 7| 0| 7| 5| 3| 8|
| 8| 6| 6| 7| 3| 8| 3| 0| 8| 8| 6| 7| 0| 8| 4| 1| 2| 6| 8| 3| 8| 9| 8| 9| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
170 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hydronephrosis | |
Infarct, Chronic | 3 |
Nephropathy, Chronic | 2 1 1 2 1 2 2 1 1 1 2 2 2 1 |
Renal Tubule, Pigmentation | 1 |
Transitional Epithelium, Hyperplasia,| |
Focal | 2 |
__________________________________________________________________________|
Ureter | |
Dilatation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
_____________________________________________________________________________________________________________________
| 3| 2| 6| 4| 4| 6| 6| 5| 4| 4| 4| 4| 4| 4| 2| 5| 4| 3| 3| 3| 6| 6| 5| 5| 3|
DAY ON TEST | 6| 7| 0| 4| 3| 4| 4| 6| 7| 3| 8| 8| 7| 1| 8| 5| 2| 7| 5| 4| 4| 4| 6| 5| 7|
| 1| 4| 2| 9| 6| 8| 1| 1| 6| 6| 3| 3| 6| 9| 7| 0| 4| 8| 8| 4| 8| 8| 2| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
170 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
Descending Colon, Hemorrhage, Focal | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + A + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 1 2 1 1 2 2 1 3 1 3 2 1 1 1 1 2 3 2 1|
Clear Cell Focus | 1 2 2 1 2 1|
Degeneration, Cystic, Focal | |
Eosinophilic Focus | 3 1 2 2 2 2 |
Fatty Change | 3 4 |
Granuloma | 3 2 |
Hematopoietic Cell Proliferation | 1 2 2 2 2 1 1 2 1 1 1 1 1 2 1 1|
Hepatodiaphragmatic Nodule | |
Hepatodiaphragmatic Nodule, Multiple | X |
Necrosis, Coagulative | 4 |
Necrosis, Focal | 2 |
Necrosis, Multifocal | 1 |
Regeneration, Diffuse | 3 |
Regeneration, Focal | 2 |
Regeneration, Multifocal | 4 |
Vacuolization Cytoplasmic, Diffuse | 2|
Vacuolization Cytoplasmic, Multifocal| 2 |
Bile Duct, Hyperplasia | 2 |
Centrilobular, Degeneration, Diffuse | 2 2 |
Centrilobular, Degeneration | |
Centrilobular, Necrosis, Diffuse | 1 2 4 |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + +|
Fat, Accessory Spleen | X|
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
__________________________________________________________________________|
Pharynx | + + |
Mucosa, Palate, Hyperplasia, Focal | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
_____________________________________________________________________________________________________________________
| 3| 2| 6| 4| 4| 6| 6| 5| 4| 4| 4| 4| 4| 4| 2| 5| 4| 3| 3| 3| 6| 6| 5| 5| 3|
DAY ON TEST | 6| 7| 0| 4| 3| 4| 4| 6| 7| 3| 8| 8| 7| 1| 8| 5| 2| 7| 5| 4| 4| 4| 6| 5| 7|
| 1| 4| 2| 9| 6| 8| 1| 1| 6| 6| 3| 3| 6| 9| 7| 0| 4| 8| 8| 4| 8| 8| 2| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
170 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Atrophy | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 |
Hyperkeratosis | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion, Focal | |
Erosion, Multifocal | |
Necrosis, Multifocal | 3 |
__________________________________________________________________________|
Tongue | |
Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 1 2 2 2 1 1 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Ectasia | 2 |
Hyperplasia, Multifocal | 2 |
Hypertrophy, Focal | |
Hypertrophy, Multifocal | 2 |
Vacuolization Cytoplasmic, Diffuse | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hyperplasia, Focal | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pigmentation | |
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Cyst | X X X X X X X X|
Pars Distalis, Hyperplasia, Focal | 2 2 |
Pars Distalis, Hyperplasia, | |
Multifocal | |
Pars Distalis, Necrosis, Focal | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
_____________________________________________________________________________________________________________________
| 3| 2| 6| 4| 4| 6| 6| 5| 4| 4| 4| 4| 4| 4| 2| 5| 4| 3| 3| 3| 6| 6| 5| 5| 3|
DAY ON TEST | 6| 7| 0| 4| 3| 4| 4| 6| 7| 3| 8| 8| 7| 1| 8| 5| 2| 7| 5| 4| 4| 4| 6| 5| 7|
| 1| 4| 2| 9| 6| 8| 1| 1| 6| 6| 3| 3| 6| 9| 7| 0| 4| 8| 8| 4| 8| 8| 2| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
170 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Clitoral Gland | + + + M + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Cyst | |
Ectasia | 3 3 2 3 |
Hyperplasia, Focal | 2 |
Hyperplasia, Multifocal, Squamous | 1 |
Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 3 |
Hydrometra | 3 3 |
Cervix, Fibrosis | 2 |
Endometrium, Cyst | 3 X 3 |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
Myelofibrosis | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Hemorrhage | |
Pancreatic, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hemorrhage | |
Hyperplasia, Lymphoid | 4 |
Hyperplasia, Reticulum Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hemorrhage | |
Hyperplasia, Lymphoid | |
Hyperplasia, Reticulum Cell | 2 1 2 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hematopoietic Cell Proliferation | 3 3 4 3 3 3 4 3 3 3 2 3 3 2 2 4 3|
Hemorrhage, Focal | |
Infarct | 3 |
Pigmentation | |
__________________________________________________________________________|
Thymus | + + + + + + + + M M + + + + + + + + + + + + + + +|
Atrophy | |
Congestion | |
Hemorrhage, Focal | 2 2 |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
_____________________________________________________________________________________________________________________
| 3| 2| 6| 4| 4| 6| 6| 5| 4| 4| 4| 4| 4| 4| 2| 5| 4| 3| 3| 3| 6| 6| 5| 5| 3|
DAY ON TEST | 6| 7| 0| 4| 3| 4| 4| 6| 7| 3| 8| 8| 7| 1| 8| 5| 2| 7| 5| 4| 4| 4| 6| 5| 7|
| 1| 4| 2| 9| 6| 8| 1| 1| 6| 6| 3| 3| 6| 9| 7| 0| 4| 8| 8| 4| 8| 8| 2| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
170 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Ectasia | 2 3 3 3 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + |
Sternum, Osteopetrosis | 3 3 4 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Meninges, Infiltration Cellular, | |
Mononuclear Cell | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 2 2 1 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2|
Infiltration Cellular, Histiocyte | 2 |
Thrombosis | 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 3 1 |
Alveolus, Pigmentation | 1 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 3 |
Inflammation, Chronic Active | |
Synechia | 2 |
Cornea, Necrosis | |
Retina, Degeneration | 3 |
__________________________________________________________________________|
Harderian Gland | |
Inflammation, Chronic | |
__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 2 1 2 3 1 2 3 2 2 2 2 4 |
Hyperplasia, Focal | 2 2 2|
Hyperplasia, Focal, Squamous | 2 1 1 1 2 |
Hyperplasia, Multifocal | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
_____________________________________________________________________________________________________________________
| 3| 2| 6| 4| 4| 6| 6| 5| 4| 4| 4| 4| 4| 4| 2| 5| 4| 3| 3| 3| 6| 6| 5| 5| 3|
DAY ON TEST | 6| 7| 0| 4| 3| 4| 4| 6| 7| 3| 8| 8| 7| 1| 8| 5| 2| 7| 5| 4| 4| 4| 6| 5| 7|
| 1| 4| 2| 9| 6| 8| 1| 1| 6| 6| 3| 3| 6| 9| 7| 0| 4| 8| 8| 4| 8| 8| 2| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
170 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hydronephrosis | |
Infarct, Chronic | |
Nephropathy, Chronic | 1 1 2 2 1 1 2 1 1 1 1 2 2 1 2 |
Renal Tubule, Pigmentation | 3 1 |
Transitional Epithelium, Hyperplasia,| |
Focal | |
__________________________________________________________________________|
Ureter | |
Dilatation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
__________________________________________________________________________________________________________________________________
| 6| 5| 4| 4| 3| 6| 5| 5| 4| 3| 5| 5| 4| 4| 3| 5| 4| 3| 3| 2| 5| 5| 4| 3| 3| |
DAY ON TEST | 1| 5| 8| 3| 0| 4| 6| 3| 6| 3| 2| 0| 8| 5| 0| 0| 6| 5| 3| 2| 8| 6| 2| 3| 3| |
| 6| 0| 3| 6| 9| 8| 3| 3| 5| 9| 7| 1| 3| 0| 4| 5| 8| 4| 1| 0| 3| 4| 4| 9| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
170 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Hemorrhage, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Parasite Metazoan | | 1 |
Descending Colon, Hemorrhage, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 74 |
Parasite Metazoan | | 3 1.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + A + + + + + + + + + + + + +| 73 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 73 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + A + + + + + + + + + + + + +| 72 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + A + + + + + + + + + + + + +| 72 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Basophilic Focus | 1 1 1 2 2 2 1 1 1 1 1 1 1 3 2 4| 54 1.7|
Clear Cell Focus | 2 1 1 1 2 2 1 | 18 1.4|
Degeneration, Cystic, Focal | 3 | 1 3.0|
Eosinophilic Focus | 3 3 1 2 2 2 2 | 20 2.2|
Fatty Change | 2 2| 4 2.8|
Granuloma | 2 2 | 7 2.1|
Hematopoietic Cell Proliferation | 1 2 2 1 1 1 1 2 1 2 1 1 1 2 | 43 1.4|
Hepatodiaphragmatic Nodule | | 4 |
Hepatodiaphragmatic Nodule, Multiple | | 1 |
Necrosis, Coagulative | | 1 4.0|
Necrosis, Focal | 1 | 5 1.8|
Necrosis, Multifocal | | 1 1.0|
Regeneration, Diffuse | | 2 3.0|
Regeneration, Focal | | 1 2.0|
Regeneration, Multifocal | 3 | 2 3.5|
Vacuolization Cytoplasmic, Diffuse | 2 | 3 2.0|
Vacuolization Cytoplasmic, Multifocal| | 1 2.0|
Bile Duct, Hyperplasia | | 2 2.0|
Centrilobular, Degeneration, Diffuse | 2 4 | 7 1.9|
Centrilobular, Degeneration | 2 | 1 2.0|
Centrilobular, Necrosis, Diffuse | 2 2 | 5 2.2|
Centrilobular, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + | 8 |
Fat, Accessory Spleen | | 1 |
Fat, Necrosis | 2 3 3 | 5 2.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
__________________________________________________________________________________________________________________________________
| 6| 5| 4| 4| 3| 6| 5| 5| 4| 3| 5| 5| 4| 4| 3| 5| 4| 3| 3| 2| 5| 5| 4| 3| 3| |
DAY ON TEST | 1| 5| 8| 3| 0| 4| 6| 3| 6| 3| 2| 0| 8| 5| 0| 0| 6| 5| 3| 2| 8| 6| 2| 3| 3| |
| 6| 0| 3| 6| 9| 8| 3| 3| 5| 9| 7| 1| 3| 0| 4| 5| 8| 4| 1| 0| 3| 4| 4| 9| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
170 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Atrophy | 2 | 4 1.5|
__________________________________________________________________________|____________|
Pharynx | + + + | 6 |
Mucosa, Palate, Hyperplasia, Focal | | 2 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Atrophy | 3 | 2 2.5|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 74 |
Acanthosis | 3| 3 2.7|
Hyperkeratosis | 2| 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Erosion, Focal | 2 | 1 2.0|
Erosion, Multifocal | 1 | 1 1.0|
Necrosis, Multifocal | | 1 3.0|
__________________________________________________________________________|____________|
Tongue | + + +| 5 |
Hyperplasia, Focal | 3| 2 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Cardiomyopathy, Chronic | 1 2 2 1 1 | 21 1.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Congestion | | 1 2.0|
Ectasia | | 1 2.0|
Hyperplasia, Multifocal | | 1 2.0|
Hypertrophy, Focal | | 1 2.0|
Hypertrophy, Multifocal | | 1 2.0|
Vacuolization Cytoplasmic, Diffuse | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 74 |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hyperplasia, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + M + + + + + + + + + + M + +| 70 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Pigmentation | | 1 2.0|
Pars Distalis, Angiectasis | 2 | 3 2.0|
Pars Distalis, Cyst | X X X X | 17 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
__________________________________________________________________________________________________________________________________
| 6| 5| 4| 4| 3| 6| 5| 5| 4| 3| 5| 5| 4| 4| 3| 5| 4| 3| 3| 2| 5| 5| 4| 3| 3| |
DAY ON TEST | 1| 5| 8| 3| 0| 4| 6| 3| 6| 3| 2| 0| 8| 5| 0| 0| 6| 5| 3| 2| 8| 6| 2| 3| 3| |
| 6| 0| 3| 6| 9| 8| 3| 3| 5| 9| 7| 1| 3| 0| 4| 5| 8| 4| 1| 0| 3| 4| 4| 9| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
170 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Hyperplasia, Focal | 2 2 | 7 2.1|
Pars Distalis, Hyperplasia, | | |
Multifocal | 2 | 1 2.0|
Pars Distalis, Necrosis, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
C-Cell, Hyperplasia, Focal | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 74 |
Atrophy | 2 2| 2 2.0|
Cyst | 2| 1 2.0|
Ectasia | 4 4 3 | 11 3.2|
Hyperplasia, Focal | 1 2 | 7 1.7|
Hyperplasia, Multifocal, Squamous | | 1 1.0|
Inflammation, Chronic Active | | 1 1.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Cyst | X X | 4 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Fibrosis | | 2 2.5|
Hydrometra | 3 | 4 3.3|
Cervix, Fibrosis | | 1 2.0|
Endometrium, Cyst | 3 3 | 6 2.8|
__________________________________________________________________________|____________|
Vagina | +| 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Hyperplasia | 2 2 2 2 | 9 2.0|
Myelofibrosis | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Mediastinal, Hemorrhage | 3 | 1 3.0|
Pancreatic, Pigmentation | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + +| 74 |
Congestion | 2 | 3 2.0|
Hemorrhage | 3 | 1 3.0|
Hyperplasia, Lymphoid | | 3 3.3|
Hyperplasia, Reticulum Cell | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
__________________________________________________________________________________________________________________________________
| 6| 5| 4| 4| 3| 6| 5| 5| 4| 3| 5| 5| 4| 4| 3| 5| 4| 3| 3| 2| 5| 5| 4| 3| 3| |
DAY ON TEST | 1| 5| 8| 3| 0| 4| 6| 3| 6| 3| 2| 0| 8| 5| 0| 0| 6| 5| 3| 2| 8| 6| 2| 3| 3| |
| 6| 0| 3| 6| 9| 8| 3| 3| 5| 9| 7| 1| 3| 0| 4| 5| 8| 4| 1| 0| 3| 4| 4| 9| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
170 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Atrophy | 3 | 1 3.0|
Hemorrhage | | 1 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
Hyperplasia, Reticulum Cell | 3 1 2 2 2 2 | 18 1.9|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Atrophy | 3 | 1 3.0|
Hematopoietic Cell Proliferation | 2 4 4 3 3 4 2 3 3 3 4 2 3 2 3 3 3 3 3 3| 50 3.0|
Hemorrhage, Focal | 2 | 1 2.0|
Infarct | | 1 3.0|
Pigmentation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + M + + + + + + + + + M + + + M + + + + + + + + +| 68 |
Atrophy | 3 | 1 3.0|
Congestion | | 1 2.0|
Hemorrhage, Focal | | 2 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Duct, Ectasia | 3 3 3 2 3 | 12 2.7|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + | 8 |
Sternum, Osteopetrosis | 4 | 7 3.1|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Meninges, Infiltration Cellular, | | |
Mononuclear Cell | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Hyperplasia, Lymphoid | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 60 2.0|
Infiltration Cellular, Histiocyte | 2 1 | 4 1.5|
Thrombosis | | 1 1.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 1 | 5 1.6|
Alveolus, Pigmentation | | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
__________________________________________________________________________________________________________________________________
| 6| 5| 4| 4| 3| 6| 5| 5| 4| 3| 5| 5| 4| 4| 3| 5| 4| 3| 3| 2| 5| 5| 4| 3| 3| |
DAY ON TEST | 1| 5| 8| 3| 0| 4| 6| 3| 6| 3| 2| 0| 8| 5| 0| 0| 6| 5| 3| 2| 8| 6| 2| 3| 3| |
| 6| 0| 3| 6| 9| 8| 3| 3| 5| 9| 7| 1| 3| 0| 4| 5| 8| 4| 1| 0| 3| 4| 4| 9| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
170 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Inflammation, Acute | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 5 |
Cataract | 2 | 3 3.0|
Inflammation, Chronic Active | | 1 4.0|
Synechia | | 1 2.0|
Cornea, Necrosis | | 1 4.0|
Retina, Degeneration | 3 3 | 3 3.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Ectasia | 2 2 1 3 3 3 2 2 2 2 2| 29 2.1|
Hyperplasia, Focal | 2 | 6 1.7|
Hyperplasia, Focal, Squamous | 1 2 | 7 1.4|
Hyperplasia, Multifocal | | 1 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Atrophy | 3 | 1 3.0|
Hydronephrosis | 3 2 4 | 3 3.0|
Infarct, Chronic | | 1 3.0|
Nephropathy, Chronic | 1 1 1 1 2 2 2 1 1 | 38 1.4|
Renal Tubule, Pigmentation | 1 1 | 5 1.4|
Transitional Epithelium, Hyperplasia,| | |
Focal | | 1 2.0|
__________________________________________________________________________|____________|
Ureter | + + | 2 |
Dilatation | 3 4 | 2 3.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Hemorrhage | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
_____________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 3| 3| 3| 6| 4| 3| 2| 2| 4| 4| 4| 3| 3|
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 5| 9| 5| 3| 1| 2| 6| 6| 5| 3| 0| 0| 7| 4|
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 5| 8| 9| 0| 4| 3| 2| 1| 1| 8| 8| 8| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
330 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + A + + + + +|
Hemorrhage, Focal | 4 |
Submucosa, Inflammation, Acute | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + A + + + + +|
Parasite Metazoan | X |
Muscularis, Mineralization | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + A + + + + +|
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + +|
Basophilic Focus | 1 3 1 1 4 3 2 3 1 1 1|
Clear Cell Focus | 1 1 4 1 1|
Cyst | |
Degeneration, Cystic, Focal | 1 2 |
Degeneration, Cystic | |
Eosinophilic Focus | 1 1 2 2 2 1 2|
Fatty Change | |
Granuloma | 2 1 |
Hematopoietic Cell Proliferation | 2 1 1 1 2 1 2 1 1|
Hepatodiaphragmatic Nodule | X |
Necrosis, Coagulative | 4 |
Necrosis, Focal | 1 2 2 1 |
Necrosis, Multifocal | |
Regeneration, Diffuse | |
Regeneration, Multifocal | 3 |
Thrombosis | |
Vacuolization Cytoplasmic, Diffuse | |
Vacuolization Cytoplasmic, Focal | |
Bile Duct, Inflammation, Chronic | |
Centrilobular, Degeneration, Diffuse | |
Centrilobular, Degeneration | |
Centrilobular, Necrosis, Diffuse | |
Kupffer Cell, Pigmentation | |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + +|
Hemorrhage, Focal | |
__________________________________________________________________________|
Pharynx | |
Mucosa, Palate, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
_____________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 3| 3| 3| 6| 4| 3| 2| 2| 4| 4| 4| 3| 3|
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 5| 9| 5| 3| 1| 2| 6| 6| 5| 3| 0| 0| 7| 4|
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 5| 8| 9| 0| 4| 3| 2| 1| 1| 8| 8| 8| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
330 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + A + + + + +|
Acanthosis | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + A + + + + +|
Erosion, Focal | 1 3 |
Inflammation, Acute | |
Mineralization | |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 1 1 1 1|
Artery, Mineralization, Multifocal | |
Atrium, Thrombosis | |
Epicardium, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hypertrophy, Focal | |
Infiltration Cellular, Lymphocyte | |
Necrosis, Focal | |
Vacuolization Cytoplasmic, Diffuse | 2 |
Vacuolization Cytoplasmic, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | X X X X X X|
Pars Distalis, Hyperplasia, Focal | |
Pars Distalis, Necrosis, Focal | |
Pars Distalis, Pigmentation, Focal | |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + A + + + + +|
C-Cell, Hyperplasia, Focal | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
_____________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 3| 3| 3| 6| 4| 3| 2| 2| 4| 4| 4| 3| 3|
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 5| 9| 5| 3| 1| 2| 6| 6| 5| 3| 0| 0| 7| 4|
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 5| 8| 9| 0| 4| 3| 2| 1| 1| 8| 8| 8| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
330 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + M + + + + + + M + + + + +|
Atrophy | 2 |
Ectasia | 2 2 |
Hyperplasia, Focal | 2|
Hyperplasia, Focal, Squamous | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + A + + + + +|
Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + +|
Hydrometra | 2 |
Endometrium, Cyst | 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + +|
Axillary, Hyperplasia, Lymphoid | |
Mediastinal, Congestion | |
Mediastinal, Hemorrhage | |
Mediastinal, Hyperplasia, Lymphoid | 2 3 |
Mediastinal, Infiltration Cellular, | |
Histiocyte | |
Pancreatic, Congestion | |
Pancreatic, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + A + + + + +|
Atrophy | |
Erythrophagocytosis | 3 |
Hyperplasia, Reticulum Cell | 2 3 2 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + +|
Atrophy | 4 2 |
Hematopoietic Cell Proliferation | 3 2 3 3 3 4 2 2 4 3 3|
Pigmentation | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + +|
Galactocele | |
Duct, Ectasia | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + +|
Acanthosis | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
_____________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 3| 3| 3| 6| 4| 3| 2| 2| 4| 4| 4| 3| 3|
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 5| 9| 5| 3| 1| 2| 6| 6| 5| 3| 0| 0| 7| 4|
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 5| 8| 9| 0| 4| 3| 2| 1| 1| 8| 8| 8| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
330 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | |
Sternum, Osteopetrosis | |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + +|
Cerebrum, Necrosis, Focal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + +|
Congestion | |
Foreign Body | 2 |
Hyperplasia, Lymphoid | 2 2 2 2 2 2 2 2 2 2 2 2 2|
Infiltration Cellular, Histiocyte | 2 2 1 |
Inflammation, Acute, Multifocal | 4 |
Inflammation, Focal, Suppurative | |
Parasite Metazoan | |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
Bronchiole, Hyperplasia, Multifocal | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + +|
Fungus | |
Hyperkeratosis, Focal | |
Inflammation, Chronic | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
Inflammation, Chronic | |
__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + + + +|
Ectasia | 3 2 2 3 |
Hyperplasia, Focal | 4 2 2 |
Hyperplasia, Focal, Squamous | 1 1 2 1 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 4 |
Nephropathy, Chronic | 1 1 2 1 2 1 1 1 1|
Cortex, Cyst | |
Pelvis, Dilatation | 2 |
Renal Tubule, Mineralization | |
Renal Tubule, Necrosis, Focal | |
Renal Tubule, Pigmentation | 2 |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
_____________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 3| 3| 3| 6| 4| 3| 2| 2| 4| 4| 4| 3| 3|
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 5| 9| 5| 3| 1| 2| 6| 6| 5| 3| 0| 0| 7| 4|
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 5| 8| 9| 0| 4| 3| 2| 1| 1| 8| 8| 8| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
330 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Vacuolization | |
Cytoplasmic | |
__________________________________________________________________________|
Ureter | + |
Dilatation | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
_____________________________________________________________________________________________________________________
| 4| 4| 3| 3| 3| 6| 5| 4| 4| 2| 5| 4| 4| 3| 3| 5| 4| 4| 3| 2| 4| 4| 4| 4| 3|
DAY ON TEST | 3| 3| 5| 4| 3| 1| 4| 6| 2| 8| 9| 8| 8| 7| 4| 6| 3| 3| 1| 7| 5| 5| 2| 0| 0|
| 6| 1| 4| 4| 9| 3| 8| 5| 4| 7| 6| 3| 3| 8| 4| 0| 1| 0| 7| 0| 2| 0| 4| 8| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
330 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + M + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | |
Submucosa, Inflammation, Acute | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
Muscularis, Mineralization | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2 3 1 2 2 2 2 3 2 3 2 2 2 1 3 1 2 3 1 1|
Clear Cell Focus | 2 1 2 2 2 1|
Cyst | 3 |
Degeneration, Cystic, Focal | |
Degeneration, Cystic | 1 2 |
Eosinophilic Focus | 2 1 1 2 2 2 1 1 1|
Fatty Change | |
Granuloma | |
Hematopoietic Cell Proliferation | 2 1 1 1 2 2 1 2 1 2 2 1 2 1 1 2 2 1|
Hepatodiaphragmatic Nodule | |
Necrosis, Coagulative | 3 |
Necrosis, Focal | 3 2 2 |
Necrosis, Multifocal | |
Regeneration, Diffuse | 2 |
Regeneration, Multifocal | 4 4 |
Thrombosis | X |
Vacuolization Cytoplasmic, Diffuse | 2 |
Vacuolization Cytoplasmic, Focal | 2 |
Bile Duct, Inflammation, Chronic | 1 |
Centrilobular, Degeneration, Diffuse | 1 2 |
Centrilobular, Degeneration | 2 |
Centrilobular, Necrosis, Diffuse | 2 3 3 |
Kupffer Cell, Pigmentation | 3 |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis | 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + A + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | 4 |
__________________________________________________________________________|
Pharynx | + + |
Mucosa, Palate, Hyperplasia, Focal | 2 |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
_____________________________________________________________________________________________________________________
| 4| 4| 3| 3| 3| 6| 5| 4| 4| 2| 5| 4| 4| 3| 3| 5| 4| 4| 3| 2| 4| 4| 4| 4| 3|
DAY ON TEST | 3| 3| 5| 4| 3| 1| 4| 6| 2| 8| 9| 8| 8| 7| 4| 6| 3| 3| 1| 7| 5| 5| 2| 0| 0|
| 6| 1| 4| 4| 9| 3| 8| 5| 4| 7| 6| 3| 3| 8| 4| 0| 1| 0| 7| 0| 2| 0| 4| 8| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
330 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion, Focal | |
Inflammation, Acute | |
Mineralization | 2 |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 1 2 2 1 2 1 1 |
Artery, Mineralization, Multifocal | |
Atrium, Thrombosis | |
Epicardium, Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 |
Hypertrophy, Focal | 2 |
Infiltration Cellular, Lymphocyte | |
Necrosis, Focal | 3 |
Vacuolization Cytoplasmic, Diffuse | 3 |
Vacuolization Cytoplasmic, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Focal | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | X X X X X X X X |
Pars Distalis, Hyperplasia, Focal | 3 |
Pars Distalis, Necrosis, Focal | |
Pars Distalis, Pigmentation, Focal | |
Pars Intermedia, Cyst | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
_____________________________________________________________________________________________________________________
| 4| 4| 3| 3| 3| 6| 5| 4| 4| 2| 5| 4| 4| 3| 3| 5| 4| 4| 3| 2| 4| 4| 4| 4| 3|
DAY ON TEST | 3| 3| 5| 4| 3| 1| 4| 6| 2| 8| 9| 8| 8| 7| 4| 6| 3| 3| 1| 7| 5| 5| 2| 0| 0|
| 6| 1| 4| 4| 9| 3| 8| 5| 4| 7| 6| 3| 3| 8| 4| 0| 1| 0| 7| 0| 2| 0| 4| 8| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
330 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + M + + + + M M + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Ectasia | 3 2 3 2 3 3 3 |
Hyperplasia, Focal | |
Hyperplasia, Focal, Squamous | |
__________________________________________________________________________|
Ovary | + + + + + + + M + + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + A + + + + + + + + + + + + + + + + +|
Hydrometra | 2 |
Endometrium, Cyst | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axillary, Hyperplasia, Lymphoid | 2 |
Mediastinal, Congestion | 2 |
Mediastinal, Hemorrhage | 2 |
Mediastinal, Hyperplasia, Lymphoid | 3 2 |
Mediastinal, Infiltration Cellular, | |
Histiocyte | 3 |
Pancreatic, Congestion | |
Pancreatic, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + M + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | 2 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + M + + + + + + + + + + + + + + + + +|
Atrophy | 4 3 |
Erythrophagocytosis | |
Hyperplasia, Reticulum Cell | 3 2 2 1 3 3 2 2 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hematopoietic Cell Proliferation | 3 2 2 2 3 3 4 3 4 3 4 4 3 3 3 3 3 2 4 4 3|
Pigmentation | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + M + + + + + + + + + M + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | |
Duct, Ectasia | 1 3 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 |
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
_____________________________________________________________________________________________________________________
| 4| 4| 3| 3| 3| 6| 5| 4| 4| 2| 5| 4| 4| 3| 3| 5| 4| 4| 3| 2| 4| 4| 4| 4| 3|
DAY ON TEST | 3| 3| 5| 4| 3| 1| 4| 6| 2| 8| 9| 8| 8| 7| 4| 6| 3| 3| 1| 7| 5| 5| 2| 0| 0|
| 6| 1| 4| 4| 9| 3| 8| 5| 4| 7| 6| 3| 3| 8| 4| 0| 1| 0| 7| 0| 2| 0| 4| 8| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
330 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + |
Sternum, Osteopetrosis | 2 3 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebrum, Necrosis, Focal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Foreign Body | |
Hyperplasia, Lymphoid | 2 2 2 2 3 2 2 2 2 1 2 2 2 2 2 2 1 2 3 3 2 2|
Infiltration Cellular, Histiocyte | 1 2 1 1 2 1 2 2 2 1 |
Inflammation, Acute, Multifocal | |
Inflammation, Focal, Suppurative | |
Parasite Metazoan | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 3 |
Bronchiole, Hyperplasia, Multifocal | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 3 3 |
Hyperkeratosis, Focal | |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 2 3 |
Hyperplasia, Focal | 1 |
Hyperplasia, Focal, Squamous | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Nephropathy, Chronic | 1 2 1 1 2 1 1 2 1 1 2 2 2 |
Cortex, Cyst | 4 |
Pelvis, Dilatation | |
Renal Tubule, Mineralization | 3 |
Renal Tubule, Necrosis, Focal | 2 |
Renal Tubule, Pigmentation | 2 2 1 2 2 |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
_____________________________________________________________________________________________________________________
| 4| 4| 3| 3| 3| 6| 5| 4| 4| 2| 5| 4| 4| 3| 3| 5| 4| 4| 3| 2| 4| 4| 4| 4| 3|
DAY ON TEST | 3| 3| 5| 4| 3| 1| 4| 6| 2| 8| 9| 8| 8| 7| 4| 6| 3| 3| 1| 7| 5| 5| 2| 0| 0|
| 6| 1| 4| 4| 9| 3| 8| 5| 4| 7| 6| 3| 3| 8| 4| 0| 1| 0| 7| 0| 2| 0| 4| 8| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
330 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Vacuolization | |
Cytoplasmic | 3 |
__________________________________________________________________________|
Ureter | |
Dilatation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + A + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 3| 2| 5| 4| 4| 3| 3| 6| 5| 5| 4| 4| 6| 5| 4| 4| 4| | |
DAY ON TEST | 3| 3| 2| 0| 8| 6| 4| 0| 4| 4| 1| 6| 6| 8| 2| 0| 6| 9| 8| 8| | |
| 6| 1| 4| 4| 4| 0| 1| 2| 4| 4| 3| 3| 3| 3| 3| 2| 1| 1| 5| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
330 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 58 |
Hemorrhage, Focal | | 1 4.0|
Submucosa, Inflammation, Acute | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | 59 |
Parasite Metazoan | | 1 |
Muscularis, Mineralization | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 59 |
Parasite Metazoan | X | 3 1.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 60 |
Basophilic Focus | 2 2 3 1 1 2 2 1 1 2 3 3 1 1 3 2 3 | 48 2.0|
Clear Cell Focus | 2 1 1 1 | 15 1.5|
Cyst | | 1 3.0|
Degeneration, Cystic, Focal | | 2 1.5|
Degeneration, Cystic | 1 | 3 1.3|
Eosinophilic Focus | 2 2 3 3 2 4 2 2 4 2 2 2 | 28 1.9|
Fatty Change | 2 | 1 2.0|
Granuloma | 2 1 2 | 5 1.6|
Hematopoietic Cell Proliferation | 2 1 2 2 2 1 1 2 2 2 2 2 1 2 | 41 1.5|
Hepatodiaphragmatic Nodule | | 1 |
Necrosis, Coagulative | 3 | 3 3.3|
Necrosis, Focal | 1 3 | 9 1.9|
Necrosis, Multifocal | 1 | 1 1.0|
Regeneration, Diffuse | | 1 2.0|
Regeneration, Multifocal | | 3 3.7|
Thrombosis | | 1 |
Vacuolization Cytoplasmic, Diffuse | | 1 2.0|
Vacuolization Cytoplasmic, Focal | 1 | 2 1.5|
Bile Duct, Inflammation, Chronic | | 1 1.0|
Centrilobular, Degeneration, Diffuse | 3 2 | 4 2.0|
Centrilobular, Degeneration | | 1 2.0|
Centrilobular, Necrosis, Diffuse | 3 1 | 5 2.4|
Kupffer Cell, Pigmentation | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + | 7 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 3| 2| 5| 4| 4| 3| 3| 6| 5| 5| 4| 4| 6| 5| 4| 4| 4| | |
DAY ON TEST | 3| 3| 2| 0| 8| 6| 4| 0| 4| 4| 1| 6| 6| 8| 2| 0| 6| 9| 8| 8| | |
| 6| 1| 4| 4| 4| 0| 1| 2| 4| 4| 3| 3| 3| 3| 3| 2| 1| 1| 5| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
330 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Fat, Necrosis | 2 3 | 5 2.6|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 59 |
Hemorrhage, Focal | | 1 4.0|
__________________________________________________________________________|____________|
Pharynx | | 2 |
Mucosa, Palate, Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 58 |
Acanthosis | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 59 |
Erosion, Focal | | 2 2.0|
Inflammation, Acute | 3 | 1 3.0|
Mineralization | 3 | 2 2.5|
__________________________________________________________________________|____________|
Tongue | + + | 4 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 60 |
Cardiomyopathy, Chronic | 1 2 2 2 1 | 17 1.4|
Artery, Mineralization, Multifocal | 2 | 1 2.0|
Atrium, Thrombosis | X | 1 |
Epicardium, Inflammation, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + | 60 |
Hematopoietic Cell Proliferation | | 1 2.0|
Hypertrophy, Focal | | 1 2.0|
Infiltration Cellular, Lymphocyte | 2 | 1 2.0|
Necrosis, Focal | | 1 3.0|
Vacuolization Cytoplasmic, Diffuse | 3 | 3 2.7|
Vacuolization Cytoplasmic, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + | 59 |
Hematopoietic Cell Proliferation | | 1 2.0|
Hyperplasia, Focal | 1 1 | 3 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + | 59 |
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 60 |
Pars Distalis, Angiectasis | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 3| 2| 5| 4| 4| 3| 3| 6| 5| 5| 4| 4| 6| 5| 4| 4| 4| | |
DAY ON TEST | 3| 3| 2| 0| 8| 6| 4| 0| 4| 4| 1| 6| 6| 8| 2| 0| 6| 9| 8| 8| | |
| 6| 1| 4| 4| 4| 0| 1| 2| 4| 4| 3| 3| 3| 3| 3| 2| 1| 1| 5| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
330 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Cyst | X X X X X | 19 |
Pars Distalis, Hyperplasia, Focal | 2 | 2 2.5|
Pars Distalis, Necrosis, Focal | 4 | 1 4.0|
Pars Distalis, Pigmentation, Focal | 2 | 1 2.0|
Pars Intermedia, Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 59 |
C-Cell, Hyperplasia, Focal | 1 | 3 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + | 55 |
Atrophy | | 2 2.5|
Ectasia | 2 2 4 | 12 2.6|
Hyperplasia, Focal | 2 2 2 2 | 5 2.0|
Hyperplasia, Focal, Squamous | | 1 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + | 58 |
Cyst | X X X X | 4 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + | 59 |
Hydrometra | | 2 2.0|
Endometrium, Cyst | 1 | 3 1.7|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 60 |
Hyperplasia | 2 2 2 2 2 2 2 | 14 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + | 60 |
Axillary, Hyperplasia, Lymphoid | 2 3 | 3 2.3|
Mediastinal, Congestion | | 1 2.0|
Mediastinal, Hemorrhage | 2 | 2 2.0|
Mediastinal, Hyperplasia, Lymphoid | | 4 2.5|
Mediastinal, Infiltration Cellular, | | |
Histiocyte | | 1 3.0|
Pancreatic, Congestion | 3 | 1 3.0|
Pancreatic, Hyperplasia, Lymphoid | 3 | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | 59 |
Hemorrhage | 3 | 1 3.0|
Hyperplasia, Lymphoid | 3 | 4 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | 58 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 3| 2| 5| 4| 4| 3| 3| 6| 5| 5| 4| 4| 6| 5| 4| 4| 4| | |
DAY ON TEST | 3| 3| 2| 0| 8| 6| 4| 0| 4| 4| 1| 6| 6| 8| 2| 0| 6| 9| 8| 8| | |
| 6| 1| 4| 4| 4| 0| 1| 2| 4| 4| 3| 3| 3| 3| 3| 2| 1| 1| 5| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
330 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Atrophy | | 2 3.5|
Erythrophagocytosis | | 1 3.0|
Hyperplasia, Reticulum Cell | 2 2 3 2 2 | 18 2.2|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 60 |
Atrophy | | 2 3.0|
Hematopoietic Cell Proliferation | 4 2 4 4 2 3 3 3 4 3 3 4 4 2 3 | 47 3.1|
Pigmentation | 3 | 2 3.0|
__________________________________________________________________________|____________|
Thymus | + + M + + M + + + + + + + M + + + + + M | 54 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + | 59 |
Galactocele | X | 1 |
Duct, Ectasia | 3 | 5 2.2|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 60 |
Acanthosis | | 1 2.0|
Inflammation, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + | 4 |
Sternum, Osteopetrosis | 4 3 | 4 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 60 |
Cerebrum, Necrosis, Focal | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 60 |
Congestion | | 1 3.0|
Foreign Body | | 1 2.0|
Hyperplasia, Lymphoid | 2 2 2 2 2 2 1 1 2 2 2 2 1 2 2 2 2 2 | 53 2.0|
Infiltration Cellular, Histiocyte | 2 1 1 1 2 | 18 1.5|
Inflammation, Acute, Multifocal | | 1 4.0|
Inflammation, Focal, Suppurative | 4 | 1 4.0|
Parasite Metazoan | X | 1 |
Alveolar Epithelium, Hyperplasia, | | |
Focal | 2 | 2 2.5|
Bronchiole, Hyperplasia, Multifocal | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 3| 2| 5| 4| 4| 3| 3| 6| 5| 5| 4| 4| 6| 5| 4| 4| 4| | |
DAY ON TEST | 3| 3| 2| 0| 8| 6| 4| 0| 4| 4| 1| 6| 6| 8| 2| 0| 6| 9| 8| 8| | |
| 6| 1| 4| 4| 4| 0| 1| 2| 4| 4| 3| 3| 3| 3| 3| 2| 1| 1| 5| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
330 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Fungus | | 2 3.0|
Hyperkeratosis, Focal | 2 | 1 2.0|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + | 60 |
Ectasia | 3 2 2 3 3 2 3 4 | 15 2.6|
Hyperplasia, Focal | 2 | 5 2.2|
Hyperplasia, Focal, Squamous | 2 3 | 8 1.6|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 60 |
Inflammation, Suppurative | | 1 4.0|
Nephropathy, Chronic | 1 3 2 2 3 1 1 1 2 2 1 1 1 3 1 | 37 1.5|
Cortex, Cyst | 3 | 2 3.5|
Pelvis, Dilatation | | 1 2.0|
Renal Tubule, Mineralization | 3 | 2 3.0|
Renal Tubule, Necrosis, Focal | | 1 2.0|
Renal Tubule, Pigmentation | 2 | 7 1.9|
Renal Tubule, Vacuolization | | |
Cytoplasmic | | 1 3.0|
__________________________________________________________________________|____________|
Ureter | | 1 |
Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 59 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
_____________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 6| 5| 5| 4| 6| 6| 6| 5| 5| 6| 6| 6| 6| 6|
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 3| 2| 5| 4| 4| 4| 8| 0| 4| 4| 4| 4| 4|
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 1| 9| 2| 7| 5| 7| 1| 5| 7| 7| 7| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + +|
Basophilic Focus | 1 1 1 1 1 2 2 1 1 |
Clear Cell Focus | 1 1 1 1 1 |
Degeneration, Cystic, Focal | 1 |
Degeneration, Cystic | 1 |
Eosinophilic Focus | 2 1 1 |
Fatty Change | |
Granuloma | |
Hematopoietic Cell Proliferation | 1 1 |
Hepatodiaphragmatic Nodule | X X X |
Infarct, Chronic | |
Regeneration, Focal | 4 |
Regeneration, Multifocal | |
Vacuolization Cytoplasmic, Multifocal| |
Bile Duct, Hyperplasia | 2 2 2 2 |
Centrilobular, Necrosis, Diffuse | 4 |
Centrilobular, Necrosis | 2 |
Serosa, Hemorrhage | 2 |
__________________________________________________________________________|
Mesentery | + + + + + |
Artery, Inflammation, Chronic | |
Fat, Necrosis | 3 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + +|
Atrophy | 2 2 |
__________________________________________________________________________|
Pharynx | |
Palate, Necrosis | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + +|
Acanthosis | 2 |
Ulcer | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + +|
Erosion, Focal | |
Submucosa, Hemorrhage, Focal | |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
_____________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 6| 5| 5| 4| 6| 6| 6| 5| 5| 6| 6| 6| 6| 6|
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 3| 2| 5| 4| 4| 4| 8| 0| 4| 4| 4| 4| 4|
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 1| 9| 2| 7| 5| 7| 1| 5| 7| 7| 7| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 2 3 2 1 2 2 3 2 2 2 1 2|
Mineralization, Multifocal | |
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
Vacuolization Cytoplasmic, Focal | |
Vacuolization Cytoplasmic, Multifocal| 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 2 |
Hyperplasia | |
Hyperplasia, Multifocal | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + M + + + + + + + + + +|
Pigmentation | 3 |
Pars Distalis, Ectasia, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | |
C-Cell, Hyperplasia, Multifocal | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + +|
Atrophy | 3 |
Ectasia | 3 3 |
Hyperplasia, Focal | 2 |
Hyperplasia, Squamous | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + +|
Hyperplasia, Focal, Glandular | 1 |
Hyperplasia, Glandular, Multifocal | |
Inflammation, Chronic Active | 2 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + M + + + + + + + + + +|
Bilateral, Atrophy | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + +|
Atrophy | 4 4|
Interstitial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
_____________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 6| 5| 5| 4| 6| 6| 6| 5| 5| 6| 6| 6| 6| 6|
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 3| 2| 5| 4| 4| 4| 8| 0| 4| 4| 4| 4| 4|
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 1| 9| 2| 7| 5| 7| 1| 5| 7| 7| 7| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + A|
Ectasia | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + +|
Atrophy | 3|
Hematopoietic Cell Proliferation | 3 |
Hyperplasia, Reticulum Cell | |
__________________________________________________________________________|
Thymus | + + + M + + + + + + + + + + +|
Atrophy | |
Epithelial Cell, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M + + + + + M + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + +|
Abscess | 3 |
Acanthosis, Multifocal | |
Cyst Epithelial Inclusion | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + +|
Foreign Body | 3|
Hyperplasia, Lymphoid | 2 2 1 2 2 2 2 2 2 1 1 2 |
Inflammation, Suppurative | 4|
Alveolar Epithelium, Hyperplasia, | |
Focal | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + +|
Foreign Body | 4|
Fungus | 2 |
Hyperkeratosis | |
Inflammation, Acute | 2 4|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
_____________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 6| 5| 5| 4| 6| 6| 6| 5| 5| 6| 6| 6| 6| 6|
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 3| 2| 5| 4| 4| 4| 8| 0| 4| 4| 4| 4| 4|
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 1| 9| 2| 7| 5| 7| 1| 5| 7| 7| 7| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cataract | |
Degeneration | |
Retina, Degeneration | |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + + + +|
Ectasia | 1 2 1 2 2 2 1 2 2 2 1 2|
Hyperplasia, Multifocal | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 3 3 3 3 2 3 2 2 3 2 2 |
Proximal Convoluted Renal Tubule, | |
Necrosis, Diffuse | |
Renal Tubule, Pigmentation | 4 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + +|
Edema | 3 |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 0| 6| 6| 6| 6| 6|
DAY ON TEST | 4| 4| 4| 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 4| 4| 4| 0| 7| 4| 4| 4| 4| 4|
| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 6| 7| 7| 9| 7| 7| 7| 3| 3| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2 1 1 1 1 1 1 1 1 2 1 1 1 2 1 1 1 1|
Clear Cell Focus | 1 1 1 1 1 1 |
Degeneration, Cystic, Focal | 1 1 2 |
Degeneration, Cystic | 1 1 1 1 |
Eosinophilic Focus | 1 |
Fatty Change | 2 |
Granuloma | 2 |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X |
Infarct, Chronic | 3 |
Regeneration, Focal | 2 |
Regeneration, Multifocal | |
Vacuolization Cytoplasmic, Multifocal| 2 2 |
Bile Duct, Hyperplasia | 2 2 2 2 2 2 |
Centrilobular, Necrosis, Diffuse | 4 |
Centrilobular, Necrosis | 2 |
Serosa, Hemorrhage | |
__________________________________________________________________________|
Mesentery | + + + + + + + + + +|
Artery, Inflammation, Chronic | 3 |
Fat, Necrosis | 3 3 3 3 3 3 3|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 2 2 2 2 |
__________________________________________________________________________|
Pharynx | + |
Palate, Necrosis | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2|
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion, Focal | 2 |
Submucosa, Hemorrhage, Focal | |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 0| 6| 6| 6| 6| 6|
DAY ON TEST | 4| 4| 4| 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 4| 4| 4| 0| 7| 4| 4| 4| 4| 4|
| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 6| 7| 7| 9| 7| 7| 7| 3| 3| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 2 2 2 1 2 2 2 2 2 3 2 2 2 2 2 2 |
Mineralization, Multifocal | 4 |
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2|
Vacuolization Cytoplasmic, Focal | 2 |
Vacuolization Cytoplasmic, Multifocal| |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
Hyperplasia | 2 |
Hyperplasia, Multifocal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pigmentation | |
Pars Distalis, Ectasia, Focal | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | 1 1 |
C-Cell, Hyperplasia, Multifocal | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Ectasia | 3 3 3 |
Hyperplasia, Focal | |
Hyperplasia, Squamous | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal, Glandular | 1 1 1 |
Hyperplasia, Glandular, Multifocal | 2 |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + M + + + + +|
Bilateral, Atrophy | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Interstitial Cell, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 0| 6| 6| 6| 6| 6|
DAY ON TEST | 4| 4| 4| 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 4| 4| 4| 0| 7| 4| 4| 4| 4| 4|
| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 6| 7| 7| 9| 7| 7| 7| 3| 3| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 2|
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Reticulum Cell | 3 |
__________________________________________________________________________|
Thymus | + + + + + M + + + + + + + + + + + + + + M + + M M|
Atrophy | 4 |
Epithelial Cell, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Acanthosis, Multifocal | |
Cyst Epithelial Inclusion | X X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 3 |
Hyperplasia, Lymphoid | 2 1 3 2 2 2 2 2 2 2 2 2 1 2 2 2 2 3 2|
Inflammation, Suppurative | |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Fungus | 3|
Hyperkeratosis | 3|
Inflammation, Acute | 2 3|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 0| 6| 6| 6| 6| 6|
DAY ON TEST | 4| 4| 4| 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 4| 4| 4| 0| 7| 4| 4| 4| 4| 4|
| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 6| 7| 7| 9| 7| 7| 7| 3| 3| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
Cataract | 3 |
Degeneration | |
Retina, Degeneration | 4 4 3 |
__________________________________________________________________________|
Harderian Gland | |
__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 1 1 1 2 2 1 1 2 2 2 2 1 1 1 1 1 1 1 2|
Hyperplasia, Multifocal | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 2 2 2 2 2 2 3 2 3 3 3 3 3 3 3 3 2 3 3 2 3 3|
Proximal Convoluted Renal Tubule, | |
Necrosis, Diffuse | 3 |
Renal Tubule, Pigmentation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1| 0| 4| 4| 4| 4| 4| | |
| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 60 |
Basophilic Focus | 1 2 2 1 2 1 1 1 1 1 1 1 1 1 1 | 42 1.2|
Clear Cell Focus | 1 1 1 2 1 1 1 1 | 19 1.1|
Degeneration, Cystic, Focal | 2 1 | 6 1.3|
Degeneration, Cystic | 2 2 | 7 1.3|
Eosinophilic Focus | 1 1 | 6 1.2|
Fatty Change | 2 | 2 2.0|
Granuloma | 3 | 2 2.5|
Hematopoietic Cell Proliferation | | 2 1.0|
Hepatodiaphragmatic Nodule | | 4 |
Infarct, Chronic | | 1 3.0|
Regeneration, Focal | 3 3 | 4 3.0|
Regeneration, Multifocal | 3 | 1 3.0|
Vacuolization Cytoplasmic, Multifocal| | 2 2.0|
Bile Duct, Hyperplasia | 2 2 2 3 | 14 2.1|
Centrilobular, Necrosis, Diffuse | | 2 4.0|
Centrilobular, Necrosis | | 2 2.0|
Serosa, Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + | 22 |
Artery, Inflammation, Chronic | | 1 3.0|
Fat, Necrosis | 3 3 3 3 3 3 3 | 17 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 60 |
Atrophy | 2 2 | 9 2.1|
__________________________________________________________________________|____________|
Pharynx | | 1 |
Palate, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + M + + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + M + + + + + + + + + + + | 59 |
Acanthosis | | 2 2.0|
Ulcer | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1| 0| 4| 4| 4| 4| 4| | |
| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + M + + + + + + + + + + + | 58 |
Erosion, Focal | | 1 2.0|
Submucosa, Hemorrhage, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Tongue | + | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 60 |
Cardiomyopathy, Chronic | 2 2 2 2 1 2 2 1 2 1 2 2 2 2 2 2 3 | 47 2.0|
Mineralization, Multifocal | | 1 4.0|
Atrium, Thrombosis | X | 3 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + | 60 |
Hyperplasia, Focal | 1 | 3 1.7|
Vacuolization Cytoplasmic, Focal | | 1 2.0|
Vacuolization Cytoplasmic, Multifocal| 2 | 2 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + | 60 |
Hyperplasia, Focal | 2 3 | 4 2.3|
Hyperplasia | 3 | 2 2.5|
Hyperplasia, Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + M + + + + + + | 58 |
Pigmentation | | 1 3.0|
Pars Distalis, Ectasia, Focal | 3 | 2 2.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 60 |
C-Cell, Hyperplasia, Focal | 1 2 3 1 | 6 1.5|
C-Cell, Hyperplasia, Multifocal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + | 60 |
Atrophy | 3 3 | 4 3.0|
Ectasia | | 5 3.0|
Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1| 0| 4| 4| 4| 4| 4| | |
| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Hyperplasia, Squamous | | 1 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + | 60 |
Hyperplasia, Focal, Glandular | 2 | 5 1.2|
Hyperplasia, Glandular, Multifocal | 1 2 3 2 | 5 2.0|
Inflammation, Chronic Active | 2 2 | 5 2.2|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + | 58 |
Bilateral, Atrophy | | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + | 60 |
Atrophy | 3 | 3 3.7|
Interstitial Cell, Hyperplasia | 2 | 2 2.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 60 |
Hyperplasia | 2 | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | 60 |
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | 59 |
Ectasia | 3 | 1 3.0|
Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 60 |
Atrophy | | 3 2.7|
Hematopoietic Cell Proliferation | 2 | 3 2.3|
Hyperplasia, Reticulum Cell | 4 | 2 3.5|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + M + + M + + + + + + | 53 |
Atrophy | | 1 4.0|
Epithelial Cell, Hyperplasia, Focal | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M + + + + + + + + + + M + + + + + + | 56 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 60 |
Abscess | | 1 3.0|
Acanthosis, Multifocal | 3 | 1 3.0|
Cyst Epithelial Inclusion | | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1| 0| 4| 4| 4| 4| 4| | |
| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 60 |
Foreign Body | | 2 3.0|
Hyperplasia, Lymphoid | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 | 49 1.9|
Inflammation, Suppurative | | 1 4.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 60 |
Foreign Body | | 1 4.0|
Fungus | 2 2 | 4 2.3|
Hyperkeratosis | 2 | 2 2.5|
Inflammation, Acute | 2 2 | 6 2.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 4 |
Cataract | | 1 3.0|
Degeneration | 4 | 1 4.0|
Retina, Degeneration | | 3 3.7|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | + + + M + + + + + + + + + + + + + + + + | 59 |
Ectasia | 2 2 2 2 2 3 3 2 2 2 1 | 42 1.6|
Hyperplasia, Multifocal | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 60 |
Nephropathy, Chronic | 3 2 2 3 1 2 3 2 2 2 3 2 3 2 2 3 2 3 2 2 | 53 2.5|
Proximal Convoluted Renal Tubule, | | |
Necrosis, Diffuse | | 1 3.0|
Renal Tubule, Pigmentation | | 1 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 60 |
Edema | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 64
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
_____________________________________________________________________________________________________________________
| 6| 5| 5| 4| 3| 6| 6| 6| 6| 4| 6| 6| 6| 5| 2| 6| 6| 6| 5| 5| 6| 5| 5| 4| 4|
DAY ON TEST | 4| 9| 5| 8| 5| 4| 4| 1| 1| 8| 1| 0| 0| 4| 6| 4| 1| 0| 9| 7| 1| 3| 1| 8| 8|
| 4| 6| 2| 0| 3| 4| 7| 8| 8| 3| 0| 3| 3| 6| 2| 1| 1| 2| 6| 8| 8| 8| 5| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
80 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + A + + + + + + + + + + +|
Hyperkeratosis | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + A + + + + + + + + + + +|
Mucosa, Necrosis, Focal | |
Submucosa, Edema | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + A + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + M + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 1 2 2 1 2 1 2 1 1 2 2 1 1 1 2 1 1|
Clear Cell Focus | 1 1 1 1 |
Degeneration, Cystic, Focal | |
Degeneration, Cystic | 2 3 2 1 1 2 2 2 2 2 2 |
Degeneration, Cystic, Multifocal | |
Ectasia, Multifocal | |
Eosinophilic Focus | 2 2 1 1 2 1 1 2 |
Granuloma | 3 2|
Hematopoietic Cell Proliferation | 2 1 1 1 1 2 1 1 2 |
Hepatodiaphragmatic Nodule | X X |
Hepatodiaphragmatic Nodule, Multiple | |
Infarct, Chronic | 4 3 |
Necrosis, Coagulative | 2 |
Necrosis, Focal | 1 |
Regeneration, Diffuse | |
Regeneration, Focal | |
Regeneration, Multifocal | 2 |
Thrombosis | X X |
Vacuolization Cytoplasmic, Multifocal| 1 |
Bile Duct, Hyperplasia | 2 |
Centrilobular, Degeneration, Diffuse | 1 |
Centrilobular, Necrosis, Diffuse | 4 4 3 4 |
Centrilobular, Necrosis, Focal | |
Centrilobular, Necrosis | 2 2 |
Centrilobular, Necrosis, Multifocal | |
__________________________________________________________________________|
Mesentery | + + + + |
Artery, Mineralization | |
Fat, Necrosis | 3 3 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + A + + + + + + + + + + +|
Atrophy | 2 2|
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
_____________________________________________________________________________________________________________________
| 6| 5| 5| 4| 3| 6| 6| 6| 6| 4| 6| 6| 6| 5| 2| 6| 6| 6| 5| 5| 6| 5| 5| 4| 4|
DAY ON TEST | 4| 9| 5| 8| 5| 4| 4| 1| 1| 8| 1| 0| 0| 4| 6| 4| 1| 0| 9| 7| 1| 3| 1| 8| 8|
| 4| 6| 2| 0| 3| 4| 7| 8| 8| 3| 0| 3| 3| 6| 2| 1| 1| 2| 6| 8| 8| 8| 5| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
80 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Acinus, Hypertrophy, Multifocal | |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + A + + + + + + + + + + +|
Atrophy | |
Interlobular, Edema | |
Parotid Gland, Atrophy | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + A + + + + + + + + + + +|
Erosion, Multifocal | 3 3 |
Mucosa, Muscularis, Mineralization | |
__________________________________________________________________________|
Tongue | + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + A + + + + + + + + + + +|
Cardiomyopathy, Chronic | 3 2 2 2 2 1 2 1 2 2 2 1 1 2 |
Artery, Mineralization | |
Atrium, Thrombosis | X X X X X X X |
Epicardium, Inflammation, Chronic | |
Active, Focal | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + A + + + + + + + + + + +|
Congestion | |
Hyperplasia, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + A + + + + + + + + + + +|
Congestion | |
Hyperplasia, Focal | 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + A + + + + + + + + + + +|
Hyperplasia | 1 2 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + A + + + + + + + + + + +|
Pars Distalis, Cyst | X 2|
Pars Distalis, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + A + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + M + + + + + + + + + A + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
_____________________________________________________________________________________________________________________
| 6| 5| 5| 4| 3| 6| 6| 6| 6| 4| 6| 6| 6| 5| 2| 6| 6| 6| 5| 5| 6| 5| 5| 4| 4|
DAY ON TEST | 4| 9| 5| 8| 5| 4| 4| 1| 1| 8| 1| 0| 0| 4| 6| 4| 1| 0| 9| 7| 1| 3| 1| 8| 8|
| 4| 6| 2| 0| 3| 4| 7| 8| 8| 3| 0| 3| 3| 6| 2| 1| 1| 2| 6| 8| 8| 8| 5| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
80 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Atrophy | 3 3 |
Ectasia | 3 3 4 4 3 3 3|
Hyperplasia, Focal | 2 |
Hyperplasia, Focal, Squamous | |
Hyperplasia | 1 |
Hyperplasia, Squamous | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + A + + + + + + + + + + +|
Hyperplasia, Focal, Glandular | 2 |
Hyperplasia, Glandular, Multifocal | 2 2 |
Inflammation, Chronic Active | 2 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + M + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 |
Interstitial Cell, Hyperplasia | 2 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + A + + + + + + + + + + +|
Hyperplasia | 3 |
Myelofibrosis, Focal | 1 |
Myeloid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + A + + + + + + + + + + +|
Axillary, Congestion | |
Axillary, Erythrophagocytosis | |
Mediastinal, Congestion | 2 3 |
Mediastinal, Hyperplasia, Lymphoid | |
Mediastinal, Pigmentation | |
Pancreatic, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + A + + + + + + + + + + +|
Congestion | |
Erythrophagocytosis | |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + A + + + + + + + + + + +|
Congestion | |
Hyperplasia, Lymphoid | |
Hyperplasia, Reticulum Cell | 3 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + A + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 3 4 2 3 3 3 2|
__________________________________________________________________________|
Thymus | + M M + + M M + + + + + M A + + + + + + + + M + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M + + + + + + + + + + + + + + + + + + + M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Hyperkeratosis, Focal | |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
_____________________________________________________________________________________________________________________
| 6| 5| 5| 4| 3| 6| 6| 6| 6| 4| 6| 6| 6| 5| 2| 6| 6| 6| 5| 5| 6| 5| 5| 4| 4|
DAY ON TEST | 4| 9| 5| 8| 5| 4| 4| 1| 1| 8| 1| 0| 0| 4| 6| 4| 1| 0| 9| 7| 1| 3| 1| 8| 8|
| 4| 6| 2| 0| 3| 4| 7| 8| 8| 3| 0| 3| 3| 6| 2| 1| 1| 2| 6| 8| 8| 8| 5| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
80 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic, Focal | 3 |
Necrosis | 4|
Hair Follicle, Hyperplasia, Basal | |
Cell, Focal | 3|
Subcutaneous Tissue, Edema | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + A + + + + + + + + + + +|
Congestion | |
Hyperplasia, Lymphoid | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
Infiltration Cellular, Histiocyte | 2 3 2 |
Thrombosis, Multiple | X |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
Alveolar Epithelium, Hyperplasia, | |
Multifocal | |
Artery, Mediastinum, Mineralization | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + A + + + + + + + + + + +|
Fungus | 4 4 |
Inflammation, Acute | 4 2 |
Inflammation, Chronic | |
Necrosis, Focal | 4 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + A + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + +|
Anterior Chamber, Cornea, | |
Inflammation, Acute | 3|
__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 3 3 2 2 4 2 1 2 2 2 1 2 2 2 1 1 2 3 2 2 2 |
Hyperplasia, Diffuse | |
Hyperplasia, Focal | 2 1 |
Hyperplasia, Focal, Squamous | 1 |
Hypertrophy, Diffuse | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + A + + + + + + + + + + +|
Infarct, Chronic | 4 |
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
_____________________________________________________________________________________________________________________
| 6| 5| 5| 4| 3| 6| 6| 6| 6| 4| 6| 6| 6| 5| 2| 6| 6| 6| 5| 5| 6| 5| 5| 4| 4|
DAY ON TEST | 4| 9| 5| 8| 5| 4| 4| 1| 1| 8| 1| 0| 0| 4| 6| 4| 1| 0| 9| 7| 1| 3| 1| 8| 8|
| 4| 6| 2| 0| 3| 4| 7| 8| 8| 3| 0| 3| 3| 6| 2| 1| 1| 2| 6| 8| 8| 8| 5| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
80 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Mineralization | |
Nephropathy, Chronic | 3 2 2 2 3 3 3 2 2 3 2 1 1 3 2 2 2 2 1 2|
Renal Tubule, Degeneration | |
Renal Tubule, Pigmentation | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + A + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 5| 5| 6| 6| 5| 5| 3| 6| 6| 5| 5| 5| 6| 6| 6| 6| 6| | |
DAY ON TEST | 4| 1| 0| 9| 5| 4| 4| 8| 5| 5| 0| 0| 9| 8| 5| 4| 4| 4| 4| 3| | |
| 7| 8| 9| 5| 6| 7| 7| 5| 6| 4| 6| 4| 3| 8| 8| 7| 7| 7| 7| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
80 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + | 44 |
Hyperkeratosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + A + + + + + | 43 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + A A + + + + + | 42 |
Mucosa, Necrosis, Focal | 3 | 1 3.0|
Submucosa, Edema | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + A + + + + + | 43 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + A A + + + + + | 42 |
Parasite Metazoan | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + A A + + + + + | 42 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + A A + + + + + | 42 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + A A + + + + + | 42 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + A A + + + + + | 41 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 45 |
Basophilic Focus | 2 1 1 2 2 3 1 2 2 1 1 1 | 29 1.5|
Clear Cell Focus | 1 1 2 1 1 X 1 | 11 1.1|
Degeneration, Cystic, Focal | 1 | 1 1.0|
Degeneration, Cystic | 1 3 2 2 2 3 1 2 2 2 | 21 2.0|
Degeneration, Cystic, Multifocal | 2 | 1 2.0|
Ectasia, Multifocal | 2 | 1 2.0|
Eosinophilic Focus | 2 2 3 2 2 2 1 | 15 1.7|
Granuloma | | 2 2.5|
Hematopoietic Cell Proliferation | 2 1 1 1 1 2 | 15 1.3|
Hepatodiaphragmatic Nodule | X | 3 |
Hepatodiaphragmatic Nodule, Multiple | X | 1 |
Infarct, Chronic | | 2 3.5|
Necrosis, Coagulative | | 1 2.0|
Necrosis, Focal | | 1 1.0|
Regeneration, Diffuse | 4 | 1 4.0|
Regeneration, Focal | 4 | 1 4.0|
Regeneration, Multifocal | 3 3 4 4 | 5 3.2|
Thrombosis | X | 3 |
Vacuolization Cytoplasmic, Multifocal| 2 | 2 1.5|
Bile Duct, Hyperplasia | 3 | 2 2.5|
Centrilobular, Degeneration, Diffuse | 4 1 1 | 4 1.8|
Centrilobular, Necrosis, Diffuse | 3 2 2 | 7 3.1|
Centrilobular, Necrosis, Focal | 2 | 1 2.0|
Centrilobular, Necrosis | 2 | 3 2.0|
Centrilobular, Necrosis, Multifocal | 3 2 | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 70
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 5| 5| 6| 6| 5| 5| 3| 6| 6| 5| 5| 5| 6| 6| 6| 6| 6| | |
DAY ON TEST | 4| 1| 0| 9| 5| 4| 4| 8| 5| 5| 0| 0| 9| 8| 5| 4| 4| 4| 4| 3| | |
| 7| 8| 9| 5| 6| 7| 7| 5| 6| 4| 6| 4| 3| 8| 8| 7| 7| 7| 7| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
80 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Mesentery | + + + + + | 9 |
Artery, Mineralization | 4 | 1 4.0|
Fat, Necrosis | 3 3 3 3 | 8 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 44 |
Atrophy | 3 2 | 4 2.3|
Acinus, Hypertrophy, Multifocal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pharynx | + + + | 4 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 44 |
Atrophy | 2 | 1 2.0|
Interlobular, Edema | 4 | 1 4.0|
Parotid Gland, Atrophy | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + | 44 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 44 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 44 |
Erosion, Multifocal | 4 3 2 | 5 3.0|
Mucosa, Muscularis, Mineralization | 4 | 1 4.0|
__________________________________________________________________________|____________|
Tongue | | 4 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 44 |
Cardiomyopathy, Chronic | 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 | 29 1.9|
Artery, Mineralization | 3 | 1 3.0|
Atrium, Thrombosis | X X X X X X X X | 15 |
Epicardium, Inflammation, Chronic | | |
Active, Focal | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + | 44 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + | 44 |
Congestion | 3 | 1 3.0|
Hyperplasia, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + | 44 |
Congestion | 3 | 1 3.0|
Hyperplasia, Focal | 1 1 | 4 1.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 44 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + + + + + + + + + + + + + + | 43 |
Hyperplasia | 2 | 4 1.8|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + M + + + + + | 43 |
Pars Distalis, Cyst | | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 71
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 5| 5| 6| 6| 5| 5| 3| 6| 6| 5| 5| 5| 6| 6| 6| 6| 6| | |
DAY ON TEST | 4| 1| 0| 9| 5| 4| 4| 8| 5| 5| 0| 0| 9| 8| 5| 4| 4| 4| 4| 3| | |
| 7| 8| 9| 5| 6| 7| 7| 5| 6| 4| 6| 4| 3| 8| 8| 7| 7| 7| 7| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
80 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 44 |
C-Cell, Hyperplasia, Focal | 1 1 | 4 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + | 43 |
Atrophy | 3 3 3 3 3 3 | 8 3.0|
Ectasia | 4 3 3 4 3 | 12 3.3|
Hyperplasia, Focal | 3 | 2 2.5|
Hyperplasia, Focal, Squamous | 1 2 2 | 3 1.7|
Hyperplasia | | 1 1.0|
Hyperplasia, Squamous | | 1 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + | 44 |
Hyperplasia, Focal, Glandular | 1 | 2 1.5|
Hyperplasia, Glandular, Multifocal | 1 2 | 4 1.8|
Inflammation, Chronic Active | | 2 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + M + + + + + + + + + + | 42 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + | 45 |
Atrophy | 4 3 | 4 3.8|
Interstitial Cell, Hyperplasia | 2 | 4 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + A + + + + + | 43 |
Hyperplasia | 2 2 | 3 2.3|
Myelofibrosis, Focal | | 1 1.0|
Myeloid Cell, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + | 43 |
Axillary, Congestion | 3 | 1 3.0|
Axillary, Erythrophagocytosis | 3 | 1 3.0|
Mediastinal, Congestion | 2 | 3 2.3|
Mediastinal, Hyperplasia, Lymphoid | 3 | 1 3.0|
Mediastinal, Pigmentation | 4 | 1 4.0|
Pancreatic, Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | 43 |
Congestion | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 72
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 5| 5| 6| 6| 5| 5| 3| 6| 6| 5| 5| 5| 6| 6| 6| 6| 6| | |
DAY ON TEST | 4| 1| 0| 9| 5| 4| 4| 8| 5| 5| 0| 0| 9| 8| 5| 4| 4| 4| 4| 3| | |
| 7| 8| 9| 5| 6| 7| 7| 5| 6| 4| 6| 4| 3| 8| 8| 7| 7| 7| 7| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
80 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Erythrophagocytosis | 3 | 1 3.0|
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + A + + + + + + | 42 |
Congestion | 3 | 1 3.0|
Hyperplasia, Lymphoid | 3 | 1 3.0|
Hyperplasia, Reticulum Cell | 3 | 3 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + A A + + + + + | 42 |
Hematopoietic Cell Proliferation | 3 3 4 2 | 13 2.9|
__________________________________________________________________________|____________|
Thymus | + + M + + + + + + + + M + M + + + + + M | 34 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + | 42 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 45 |
Cyst Epithelial Inclusion | X | 2 |
Hyperkeratosis, Focal | 2 | 1 2.0|
Inflammation, Chronic, Focal | | 1 3.0|
Necrosis | | 1 4.0|
Hair Follicle, Hyperplasia, Basal | | |
Cell, Focal | | 1 3.0|
Subcutaneous Tissue, Edema | 3 3 | 3 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + | 3 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + | 44 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 44 |
Congestion | 3 | 1 3.0|
Hyperplasia, Lymphoid | 2 2 2 2 2 2 2 2 3 3 2 2 | 29 2.1|
Infiltration Cellular, Histiocyte | | 3 2.3|
Thrombosis, Multiple | | 1 |
Alveolar Epithelium, Hyperplasia, | | |
Focal | 3 | 1 3.0|
Alveolar Epithelium, Hyperplasia, | | |
Multifocal | 3 | 1 3.0|
Artery, Mediastinum, Mineralization | 3 | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 44 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 73
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 5| 5| 6| 6| 5| 5| 3| 6| 6| 5| 5| 5| 6| 6| 6| 6| 6| | |
DAY ON TEST | 4| 1| 0| 9| 5| 4| 4| 8| 5| 5| 0| 0| 9| 8| 5| 4| 4| 4| 4| 3| | |
| 7| 8| 9| 5| 6| 7| 7| 5| 6| 4| 6| 4| 3| 8| 8| 7| 7| 7| 7| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
80 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Fungus | 3 | 3 3.7|
Inflammation, Acute | 2 | 3 2.7|
Inflammation, Chronic | 2 | 1 2.0|
Necrosis, Focal | | 1 4.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + | 43 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 3 |
Anterior Chamber, Cornea, | | |
Inflammation, Acute | | 1 3.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + | 45 |
Ectasia | 2 2 1 4 4 2 2 2 4 2 2 2 2 2 3 2 1 2 | 40 2.2|
Hyperplasia, Diffuse | 2 3 | 2 2.5|
Hyperplasia, Focal | 2 | 3 1.7|
Hyperplasia, Focal, Squamous | 1 2 1 | 4 1.3|
Hypertrophy, Diffuse | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 44 |
Infarct, Chronic | | 1 4.0|
Mineralization | 4 | 1 4.0|
Nephropathy, Chronic | 3 2 2 2 3 3 1 2 2 2 2 2 3 3 2 2 | 36 2.2|
Renal Tubule, Degeneration | 3 | 1 3.0|
Renal Tubule, Pigmentation | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 44 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 74
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
_____________________________________________________________________________________________________________________
| 5| 5| 5| 3| 3| 6| 5| 5| 5| 4| 5| 5| 5| 4| 4| 6| 5| 4| 3| 3| 6| 5| 5| 5| 4|
DAY ON TEST | 9| 3| 2| 9| 0| 3| 7| 6| 5| 8| 9| 6| 6| 7| 1| 4| 4| 7| 9| 3| 1| 5| 3| 3| 2|
| 1| 1| 5| 1| 4| 4| 8| 2| 6| 5| 4| 0| 1| 2| 7| 1| 1| 6| 1| 9| 6| 5| 9| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
170 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + + + + + + + + + + + + A + + + + + +|
Congestion | |
__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + A + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + + A + + + + + +|
Mucosa, Hyperplasia, Diffuse | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + + + + + + + + A + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + + + + + + + + + A + + + + + +|
Congestion | |
Mucosa, Hyperplasia, Focal | |
__________________________________________________________________________|
Liver | + + + A + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2 4 2 1 1 2 1 1 3 2 1 1 2 1 3 1 |
Clear Cell Focus | 2 2 2 2 |
Degeneration, Cystic, Focal | 1 |
Degeneration, Cystic | 1 1 1 2 1 1 2 1 2 1 |
Degeneration, Cystic, Multifocal | |
Ectasia, Multifocal | |
Eosinophilic Focus | 2 1 2 2 3 3 1 2 1 2 |
Fatty Change | 3 |
Hematopoietic Cell Proliferation | 2 1 1 2 2 2 2 1 2 1 1 1 2 |
Hepatodiaphragmatic Nodule | |
Necrosis, Coagulative | |
Necrosis, Focal | 1 |
Necrosis, Multifocal | 2 2 3 |
Regeneration, Diffuse | 3 2 3 4 |
Regeneration, Focal | 4 |
Regeneration, Multifocal | 2 4 3 |
Thrombosis | X X |
Vacuolization Cytoplasmic, Multifocal| |
Bile Duct, Hyperplasia | 2 2 2 4 |
Caudate Lobe, Pigmentation | |
Caudate Lobe, Regeneration | |
Centrilobular, Degeneration, Diffuse | 2 3 |
Centrilobular, Necrosis, Diffuse | 4 3 |
Centrilobular, Necrosis | 4 |
Periportal, Fibrosis | 4 |
__________________________________________________________________________|
Mesentery | + + + + + + + + + +|
Ectasia, Focal | |
Fat, Necrosis | 4 3 3 3 3 3 3 3 |
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
_____________________________________________________________________________________________________________________
| 5| 5| 5| 3| 3| 6| 5| 5| 5| 4| 5| 5| 5| 4| 4| 6| 5| 4| 3| 3| 6| 5| 5| 5| 4|
DAY ON TEST | 9| 3| 2| 9| 0| 3| 7| 6| 5| 8| 9| 6| 6| 7| 1| 4| 4| 7| 9| 3| 1| 5| 3| 3| 2|
| 1| 1| 5| 1| 4| 4| 8| 2| 6| 5| 4| 0| 1| 2| 7| 1| 1| 6| 1| 9| 6| 5| 9| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
170 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Vein, Ectasia | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
__________________________________________________________________________|
Pharynx | |
Palate, Hyperplasia, Focal, Squamous | |
Palate, Hyperplasia, Squamous | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + A + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + A + + + + + + + + + + + + + + A + + + + + +|
Acanthosis | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + A + + + + + + + + + + + + + A + + + + + +|
Erosion, Focal | 2 |
Erosion, Multifocal | 3 |
Hemorrhage, Multifocal | |
Mineralization | |
__________________________________________________________________________|
Tongue | + |
Necrosis, Focal | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 2 1 2 1 2 2 2 2 2 2 2 2 3 2 2 2|
Inflammation, Acute, Multifocal | |
Atrium, Thrombosis | X X X X X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + A + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Hyperplasia, Focal | |
Necrosis, Multifocal | |
Pigmentation | 4 |
Vacuolization Cytoplasmic, Diffuse | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + A + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Hyperplasia, Focal | 2 2 |
Hyperplasia, Multifocal | 3 2 1 |
Pigmentation | 4 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Congestion | 2 |
_____________________________________________________________________________________________________________________|
Page 76
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
_____________________________________________________________________________________________________________________
| 5| 5| 5| 3| 3| 6| 5| 5| 5| 4| 5| 5| 5| 4| 4| 6| 5| 4| 3| 3| 6| 5| 5| 5| 4|
DAY ON TEST | 9| 3| 2| 9| 0| 3| 7| 6| 5| 8| 9| 6| 6| 7| 1| 4| 4| 7| 9| 3| 1| 5| 3| 3| 2|
| 1| 1| 5| 1| 4| 4| 8| 2| 6| 5| 4| 0| 1| 2| 7| 1| 1| 6| 1| 9| 6| 5| 9| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
170 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + A + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | 3 |
__________________________________________________________________________|
Preputial Gland | + + + A + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 |
Cyst | |
Ectasia | 3 3 4 3 2 3 4 2 3 3 |
Hyperplasia, Focal | |
Hyperplasia, Focal, Squamous | 1 1 1 |
Hyperplasia, Multifocal, Squamous | |
Inflammation, Acute | 3 4 |
Inflammation, Chronic | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal, Glandular | 2 |
Hyperplasia, Glandular, Multifocal | 2 2 |
Inflammation, Acute | 3 2 |
Inflammation, Chronic | 2|
Inflammation, Chronic Active | 2 4 4 4 |
__________________________________________________________________________|
Seminal Vesicle | + + + M M + + + + + + + + M M + + M M M + + + + M|
Atrophy | |
Inflammation, Chronic Active | 4 |
Epithelium, Hyperplasia, Focal | 1 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Cyst | |
Degeneration | 3|
Interstitial Cell, Hyperplasia | 2 2 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + A + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 3 3 |
Hypoplasia | 2 |
Myelofibrosis, Focal | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axillary, Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
_____________________________________________________________________________________________________________________
| 5| 5| 5| 3| 3| 6| 5| 5| 5| 4| 5| 5| 5| 4| 4| 6| 5| 4| 3| 3| 6| 5| 5| 5| 4|
DAY ON TEST | 9| 3| 2| 9| 0| 3| 7| 6| 5| 8| 9| 6| 6| 7| 1| 4| 4| 7| 9| 3| 1| 5| 3| 3| 2|
| 1| 1| 5| 1| 4| 4| 8| 2| 6| 5| 4| 0| 1| 2| 7| 1| 1| 6| 1| 9| 6| 5| 9| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
170 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Axillary, Hyperplasia, Lymphoid | |
Iliac, Hyperplasia, Lymphoid | |
Inguinal, Necrosis | |
Mediastinal, Atrophy | 3 |
Mediastinal, Congestion | 3 |
Mediastinal, Hemorrhage | |
Mediastinal, Hyperplasia, Lymphoid | |
Mediastinal, Pigmentation | 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hyperplasia, Lymphoid | |
Hyperplasia, Reticulum Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + A + + + + + + + + + + + + + + A + + + + + +|
Hyperplasia, Lymphoid | 4 |
Hyperplasia, Reticulum Cell | 2 3 1 |
__________________________________________________________________________|
Spleen | + + + A + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3|
Hematopoietic Cell Proliferation | 3 4 3 3 3 3 3 3 4 2 3 |
Hyperplasia, Reticulum Cell | 4 |
Necrosis | 3 |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Thymus | + + + + + + M + M M + M + + + + + + + + + M + + +|
Atrophy | 2 |
Edema | 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 3 |
Acanthosis, Focal | |
Cyst Epithelial Inclusion | |
Granuloma, Focal | 4 |
Hyperkeratosis, Focal | |
Dermis, Fibrosis, Focal | |
Hair Follicle, Hyperplasia, Basal | |
Cell, Focal | |
Subcutaneous Tissue, Edema | 3 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | |
Cranium, Proliferation, Focal | |
__________________________________________________________________________|
Skeletal Muscle | +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 78
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
_____________________________________________________________________________________________________________________
| 5| 5| 5| 3| 3| 6| 5| 5| 5| 4| 5| 5| 5| 4| 4| 6| 5| 4| 3| 3| 6| 5| 5| 5| 4|
DAY ON TEST | 9| 3| 2| 9| 0| 3| 7| 6| 5| 8| 9| 6| 6| 7| 1| 4| 4| 7| 9| 3| 1| 5| 3| 3| 2|
| 1| 1| 5| 1| 4| 4| 8| 2| 6| 5| 4| 0| 1| 2| 7| 1| 1| 6| 1| 9| 6| 5| 9| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
170 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebrum, Hemorrhage | 1 2 |
Cerebrum, Thrombosis, Multifocal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Edema | |
Hemorrhage | 1 |
Hyperplasia, Lymphoid | 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Infiltration Cellular, Histiocyte | 2 3 1 2 |
Pigmentation, Focal | 3 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 3 1 |
Alveolar Epithelium, Hyperplasia, | |
Multifocal | 3 2 |
__________________________________________________________________________|
Nose | + + + A + + + + + + + + + + + + + + + + + + + + +|
Fungus | 3 4 3 |
Hyperkeratosis | 3 |
Inflammation, Acute | 3 4 2 |
Inflammation, Chronic | |
Necrosis, Focal | |
Necrosis, Multifocal | |
Mucosa, Hyperplasia | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 3 |
Retina, Degeneration | 4 |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia, Focal | 2 |
Ectasia | 2 1 2 2 2 2 2 3 2 2 2 2 1 1 3 2 2 1|
Hyperplasia, Focal | 1 |
Hyperplasia, Focal, Squamous | 2 |
Hyperplasia, Squamous | 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + A + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 3 |
Nephropathy, Chronic | 2 1 1 2 3 2 2 2 2 3 1 1 4 3 2 2 3 2 |
Thrombosis, Multifocal | |
Cortex, Infarct, Acute | |
_____________________________________________________________________________________________________________________|
Page 79
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
_____________________________________________________________________________________________________________________
| 5| 5| 5| 3| 3| 6| 5| 5| 5| 4| 5| 5| 5| 4| 4| 6| 5| 4| 3| 3| 6| 5| 5| 5| 4|
DAY ON TEST | 9| 3| 2| 9| 0| 3| 7| 6| 5| 8| 9| 6| 6| 7| 1| 4| 4| 7| 9| 3| 1| 5| 3| 3| 2|
| 1| 1| 5| 1| 4| 4| 8| 2| 6| 5| 4| 0| 1| 2| 7| 1| 1| 6| 1| 9| 6| 5| 9| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
170 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Proximal Convoluted Renal Tubule, | |
Necrosis, Diffuse | |
Renal Tubule, Mineralization | |
Renal Tubule, Pigmentation | 3 |
Transitional Epithelium, Hyperplasia,| |
Focal | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 4|
Inflammation, Acute | 4 4 4|
Necrosis, Diffuse | 4 4|
Necrosis, Focal | 3 |
Mucosa, Hyperplasia | 4 |
Serosa, Cyst | |
_____________________________________________________________________________________________________________________|
Page 80
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
_____________________________________________________________________________________________________________________
| 6| 5| 4| 4| 4| 5| 5| 5| 4| 4| 6| 5| 5| 5| 4| 5| 5| 5| 5| 2| 6| 5| 5| 4| 4|
DAY ON TEST | 1| 6| 8| 8| 0| 6| 7| 4| 6| 2| 0| 5| 4| 2| 8| 6| 6| 6| 5| 8| 1| 6| 3| 8| 8|
| 6| 1| 3| 3| 8| 2| 8| 6| 7| 4| 4| 3| 6| 6| 5| 1| 1| 1| 6| 4| 6| 0| 8| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
170 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + A + + + + + + + + + + + +|
Congestion | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + A + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + A + + + + + + + + + + + +|
Parasite Metazoan | X X 1 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + A + + A A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + A + + A A + + + + + + + + + + + +|
Mucosa, Hyperplasia, Diffuse | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A + + A A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A + + A A + + + + + + + + + + + +|
Congestion | |
Mucosa, Hyperplasia, Focal | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2 1 2 2 3 3 2 2 2 2 1 1 3 2 2 2 |
Clear Cell Focus | 2 2 2 2 2 2 2 |
Degeneration, Cystic, Focal | 3 |
Degeneration, Cystic | 1 2 1 1 1 1 1 2 1 |
Degeneration, Cystic, Multifocal | 2 2 |
Ectasia, Multifocal | 2 |
Eosinophilic Focus | 3 2 2 3 2 3 1 2 1 2 2 1 2 2 |
Fatty Change | 1 3 |
Hematopoietic Cell Proliferation | 1 3 2 1 1 1 1 1 1 3 1 2 |
Hepatodiaphragmatic Nodule | X |
Necrosis, Coagulative | 3 |
Necrosis, Focal | |
Necrosis, Multifocal | |
Regeneration, Diffuse | 3 3 2 |
Regeneration, Focal | 2 4 |
Regeneration, Multifocal | 3 4 3 |
Thrombosis | X |
Vacuolization Cytoplasmic, Multifocal| 2 2 2 2 2 |
Bile Duct, Hyperplasia | 2 |
Caudate Lobe, Pigmentation | |
Caudate Lobe, Regeneration | |
Centrilobular, Degeneration, Diffuse | 1 3 1 1|
Centrilobular, Necrosis, Diffuse | 2 3 |
Centrilobular, Necrosis | 1 3 |
Periportal, Fibrosis | |
__________________________________________________________________________|
Mesentery | + + + + + + + |
Ectasia, Focal | 4 |
Fat, Necrosis | 3 3 3 3 3 |
_____________________________________________________________________________________________________________________|
Page 81
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
_____________________________________________________________________________________________________________________
| 6| 5| 4| 4| 4| 5| 5| 5| 4| 4| 6| 5| 5| 5| 4| 5| 5| 5| 5| 2| 6| 5| 5| 4| 4|
DAY ON TEST | 1| 6| 8| 8| 0| 6| 7| 4| 6| 2| 0| 5| 4| 2| 8| 6| 6| 6| 5| 8| 1| 6| 3| 8| 8|
| 6| 1| 3| 3| 8| 2| 8| 6| 7| 4| 4| 3| 6| 6| 5| 1| 1| 1| 6| 4| 6| 0| 8| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
170 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Vein, Ectasia | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 1 2 |
__________________________________________________________________________|
Pharynx | + + |
Palate, Hyperplasia, Focal, Squamous | |
Palate, Hyperplasia, Squamous | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion, Focal | 1 |
Erosion, Multifocal | 2 2 |
Hemorrhage, Multifocal | 3 |
Mineralization | 3 |
__________________________________________________________________________|
Tongue | + |
Necrosis, Focal | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 2 1 2 2 2 1 2 2 2 2 2 2 1 2 2 2 2 1 3 1|
Inflammation, Acute, Multifocal | |
Atrium, Thrombosis | X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hyperplasia, Focal | |
Necrosis, Multifocal | |
Pigmentation | |
Vacuolization Cytoplasmic, Diffuse | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hyperplasia, Focal | 1 2 2 2 |
Hyperplasia, Multifocal | |
Pigmentation | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
Hyperplasia | 3 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Congestion | |
_____________________________________________________________________________________________________________________|
Page 82
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
_____________________________________________________________________________________________________________________
| 6| 5| 4| 4| 4| 5| 5| 5| 4| 4| 6| 5| 5| 5| 4| 5| 5| 5| 5| 2| 6| 5| 5| 4| 4|
DAY ON TEST | 1| 6| 8| 8| 0| 6| 7| 4| 6| 2| 0| 5| 4| 2| 8| 6| 6| 6| 5| 8| 1| 6| 3| 8| 8|
| 6| 1| 3| 3| 8| 2| 8| 6| 7| 4| 4| 3| 6| 6| 5| 1| 1| 1| 6| 4| 6| 0| 8| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
170 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | |
__________________________________________________________________________|
Preputial Gland | + + + + M + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 3 3 |
Cyst | 4 |
Ectasia | 3 3 4 3 3 2 |
Hyperplasia, Focal | 2 2 |
Hyperplasia, Focal, Squamous | 1 |
Hyperplasia, Multifocal, Squamous | |
Inflammation, Acute | |
Inflammation, Chronic | 3 |
Inflammation, Chronic Active | 2 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal, Glandular | |
Hyperplasia, Glandular, Multifocal | |
Inflammation, Acute | |
Inflammation, Chronic | |
Inflammation, Chronic Active | 3 2 4 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + M + + + M M + + + + + + + + + M + + + + +|
Atrophy | 2|
Inflammation, Chronic Active | |
Epithelium, Hyperplasia, Focal | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Cyst | |
Degeneration | |
Interstitial Cell, Hyperplasia | 2 2 2 2 2 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 3 3 3 3 |
Hypoplasia | |
Myelofibrosis, Focal | 3 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axillary, Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 83
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
_____________________________________________________________________________________________________________________
| 6| 5| 4| 4| 4| 5| 5| 5| 4| 4| 6| 5| 5| 5| 4| 5| 5| 5| 5| 2| 6| 5| 5| 4| 4|
DAY ON TEST | 1| 6| 8| 8| 0| 6| 7| 4| 6| 2| 0| 5| 4| 2| 8| 6| 6| 6| 5| 8| 1| 6| 3| 8| 8|
| 6| 1| 3| 3| 8| 2| 8| 6| 7| 4| 4| 3| 6| 6| 5| 1| 1| 1| 6| 4| 6| 0| 8| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
170 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Axillary, Hyperplasia, Lymphoid | 3 |
Iliac, Hyperplasia, Lymphoid | |
Inguinal, Necrosis | 4 |
Mediastinal, Atrophy | |
Mediastinal, Congestion | 3 4 |
Mediastinal, Hemorrhage | 2 |
Mediastinal, Hyperplasia, Lymphoid | 3 |
Mediastinal, Pigmentation | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Reticulum Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Reticulum Cell | 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Hematopoietic Cell Proliferation | 3 3 2 3 4 4 3 4 3 2 3 4 4 2 3 3 |
Hyperplasia, Reticulum Cell | |
Necrosis | |
Pigmentation, Hemosiderin | 3 |
__________________________________________________________________________|
Thymus | + + M + + M + M + + + M M + + + + + + + + + + M M|
Atrophy | |
Edema | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M + + + + + + + + + + + + + M + + M + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Acanthosis, Focal | |
Cyst Epithelial Inclusion | |
Granuloma, Focal | |
Hyperkeratosis, Focal | |
Dermis, Fibrosis, Focal | 3 |
Hair Follicle, Hyperplasia, Basal | |
Cell, Focal | 3 |
Subcutaneous Tissue, Edema | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | |
Cranium, Proliferation, Focal | |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 84
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
_____________________________________________________________________________________________________________________
| 6| 5| 4| 4| 4| 5| 5| 5| 4| 4| 6| 5| 5| 5| 4| 5| 5| 5| 5| 2| 6| 5| 5| 4| 4|
DAY ON TEST | 1| 6| 8| 8| 0| 6| 7| 4| 6| 2| 0| 5| 4| 2| 8| 6| 6| 6| 5| 8| 1| 6| 3| 8| 8|
| 6| 1| 3| 3| 8| 2| 8| 6| 7| 4| 4| 3| 6| 6| 5| 1| 1| 1| 6| 4| 6| 0| 8| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
170 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebrum, Hemorrhage | |
Cerebrum, Thrombosis, Multifocal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Edema | |
Hemorrhage | |
Hyperplasia, Lymphoid | 3 2 3 2 2 2 2 2 2 2 2 2 3 2 2 1|
Infiltration Cellular, Histiocyte | 2 2 |
Pigmentation, Focal | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 1 |
Alveolar Epithelium, Hyperplasia, | |
Multifocal | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 3 2 |
Hyperkeratosis | |
Inflammation, Acute | 3 3 |
Inflammation, Chronic | 2 |
Necrosis, Focal | |
Necrosis, Multifocal | |
Mucosa, Hyperplasia | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 3 |
Retina, Degeneration | 4 |
__________________________________________________________________________|
Harderian Gland | |
__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia, Focal | |
Ectasia | 2 3 1 3 2 2 1 1 1 4 3 2 2 2 2 3 2 |
Hyperplasia, Focal | 1 |
Hyperplasia, Focal, Squamous | 3 |
Hyperplasia, Squamous | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | |
Nephropathy, Chronic | 3 3 2 2 2 2 1 1 1 2 2 2 2 2 2 2 1 2 1 3 1|
Thrombosis, Multifocal | 3 |
Cortex, Infarct, Acute | |
_____________________________________________________________________________________________________________________|
Page 85
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
_____________________________________________________________________________________________________________________
| 6| 5| 4| 4| 4| 5| 5| 5| 4| 4| 6| 5| 5| 5| 4| 5| 5| 5| 5| 2| 6| 5| 5| 4| 4|
DAY ON TEST | 1| 6| 8| 8| 0| 6| 7| 4| 6| 2| 0| 5| 4| 2| 8| 6| 6| 6| 5| 8| 1| 6| 3| 8| 8|
| 6| 1| 3| 3| 8| 2| 8| 6| 7| 4| 4| 3| 6| 6| 5| 1| 1| 1| 6| 4| 6| 0| 8| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
170 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Proximal Convoluted Renal Tubule, | |
Necrosis, Diffuse | |
Renal Tubule, Mineralization | 4 |
Renal Tubule, Pigmentation | |
Transitional Epithelium, Hyperplasia,| |
Focal | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Acute | |
Necrosis, Diffuse | |
Necrosis, Focal | |
Mucosa, Hyperplasia | |
Serosa, Cyst | 3 |
_____________________________________________________________________________________________________________________|
Page 86
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
__________________________________________________________________________________________________________________________________
| 6| 6| 5| 5| 4| 5| 5| 5| 4| 4| 6| 5| 5| 4| 3| 6| 5| 5| 5| 4| 5| 5| 4| 4| 3| |
DAY ON TEST | 3| 0| 5| 4| 3| 5| 3| 0| 8| 7| 4| 9| 1| 2| 3| 1| 6| 5| 0| 8| 8| 3| 8| 5| 5| |
| 2| 3| 7| 6| 7| 6| 5| 8| 3| 2| 4| 6| 4| 4| 3| 6| 2| 6| 6| 5| 1| 3| 5| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
170 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 73 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 72 |
Congestion | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 73 |
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 73 |
Parasite Metazoan | | 4 1.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 70 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 70 |
Mucosa, Hyperplasia, Diffuse | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 69 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + + + + + + + +| 69 |
Congestion | 3 | 1 3.0|
Mucosa, Hyperplasia, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 74 |
Basophilic Focus | 2 2 2 2 1 1 2 2 1 1 1 1 2 2 2 1 | 48 1.8|
Clear Cell Focus | 2 2 2 1 1 | 16 1.9|
Degeneration, Cystic, Focal | 1 2 | 4 1.8|
Degeneration, Cystic | 1 1 2 3 1 2 1 1 2 | 28 1.4|
Degeneration, Cystic, Multifocal | | 2 2.0|
Ectasia, Multifocal | | 1 2.0|
Eosinophilic Focus | 1 3 2 3 2 1 2 2 2 1 1 | 35 1.9|
Fatty Change | 2 | 4 2.3|
Hematopoietic Cell Proliferation | 2 2 2 2 3 1 2 1 2 1 2 2 2 1 | 39 1.6|
Hepatodiaphragmatic Nodule | X | 2 |
Necrosis, Coagulative | | 1 3.0|
Necrosis, Focal | 2 | 2 1.5|
Necrosis, Multifocal | 2 2 | 5 2.2|
Regeneration, Diffuse | 2 | 8 2.8|
Regeneration, Focal | | 3 3.3|
Regeneration, Multifocal | 3 3 3 3 4 | 11 3.2|
Thrombosis | | 3 |
Vacuolization Cytoplasmic, Multifocal| 2 2 | 7 2.0|
Bile Duct, Hyperplasia | 3 | 6 2.5|
Caudate Lobe, Pigmentation | 3| 1 3.0|
Caudate Lobe, Regeneration | 2| 1 2.0|
Centrilobular, Degeneration, Diffuse | 2 3 2 | 9 2.0|
Centrilobular, Necrosis, Diffuse | 2 3 | 6 2.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 87
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
__________________________________________________________________________________________________________________________________
| 6| 6| 5| 5| 4| 5| 5| 5| 4| 4| 6| 5| 5| 4| 3| 6| 5| 5| 5| 4| 5| 5| 4| 4| 3| |
DAY ON TEST | 3| 0| 5| 4| 3| 5| 3| 0| 8| 7| 4| 9| 1| 2| 3| 1| 6| 5| 0| 8| 8| 3| 8| 5| 5| |
| 2| 3| 7| 6| 7| 6| 5| 8| 3| 2| 4| 6| 4| 4| 3| 6| 2| 6| 6| 5| 1| 3| 5| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
170 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Centrilobular, Necrosis | 1 | 4 2.3|
Periportal, Fibrosis | | 1 4.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + + + | 28 |
Ectasia, Focal | | 1 4.0|
Fat, Necrosis | 3 3 3 3 3 3 3 3 | 22 3.0|
Vein, Ectasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Atrophy | 2 | 5 1.8|
__________________________________________________________________________|____________|
Pharynx | + + + + + | 7 |
Palate, Hyperplasia, Focal, Squamous | 2 | 1 2.0|
Palate, Hyperplasia, Squamous | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 73 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 73 |
Acanthosis | 3 | 2 2.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 72 |
Erosion, Focal | | 2 1.5|
Erosion, Multifocal | 2 | 4 2.3|
Hemorrhage, Multifocal | | 1 3.0|
Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Tongue | + + + + | 6 |
Necrosis, Focal | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Cardiomyopathy, Chronic | 2 2 2 2 1 2 2 1 1 2 2 2 2 2 2 2 3 2 2 1| 58 1.9|
Inflammation, Acute, Multifocal | 2 | 1 2.0|
Atrium, Thrombosis | X X X X X X X X X X | 27 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 74 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 74 |
Atrophy | | 1 4.0|
Hyperplasia, Focal | 1| 1 1.0|
Necrosis, Multifocal | 4 | 1 4.0|
Pigmentation | | 1 4.0|
Vacuolization Cytoplasmic, Diffuse | 3 | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 74 |
Atrophy | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 88
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
__________________________________________________________________________________________________________________________________
| 6| 6| 5| 5| 4| 5| 5| 5| 4| 4| 6| 5| 5| 4| 3| 6| 5| 5| 5| 4| 5| 5| 4| 4| 3| |
DAY ON TEST | 3| 0| 5| 4| 3| 5| 3| 0| 8| 7| 4| 9| 1| 2| 3| 1| 6| 5| 0| 8| 8| 3| 8| 5| 5| |
| 2| 3| 7| 6| 7| 6| 5| 8| 3| 2| 4| 6| 4| 4| 3| 6| 2| 6| 6| 5| 1| 3| 5| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
170 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hyperplasia, Focal | 2 1 | 8 1.8|
Hyperplasia, Multifocal | 2 | 4 2.0|
Pigmentation | | 1 4.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Hyperplasia, Focal | 2 1 | 2 1.5|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 74 |
Hyperplasia | 2 | 3 2.3|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 74 |
Pars Distalis, Angiectasis | 2 | 1 2.0|
Pars Distalis, Congestion | | 1 2.0|
Pars Distalis, Cyst | 3 | 1 3.0|
Pars Distalis, Hyperplasia, Focal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 74 |
C-Cell, Hyperplasia, Focal | | 2 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Atypia Cellular | | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 73 |
Atrophy | 3 3 3 3 | 10 3.0|
Cyst | | 1 4.0|
Ectasia | 3 3 3 3 2 4 3 3 3 | 25 3.0|
Hyperplasia, Focal | 2 1 | 4 1.8|
Hyperplasia, Focal, Squamous | 3 | 5 1.4|
Hyperplasia, Multifocal, Squamous | 3 | 1 3.0|
Inflammation, Acute | | 2 3.5|
Inflammation, Chronic | | 1 3.0|
Inflammation, Chronic Active | | 2 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Hyperplasia, Focal, Glandular | 2 | 2 2.0|
Hyperplasia, Glandular, Multifocal | 2 | 3 2.0|
Inflammation, Acute | | 2 2.5|
Inflammation, Chronic | | 1 2.0|
Inflammation, Chronic Active | 3 3 3| 11 3.2|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + M + + + + + + + + M M + + + + + + + + M M| 58 |
Atrophy | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 89
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
__________________________________________________________________________________________________________________________________
| 6| 6| 5| 5| 4| 5| 5| 5| 4| 4| 6| 5| 5| 4| 3| 6| 5| 5| 5| 4| 5| 5| 4| 4| 3| |
DAY ON TEST | 3| 0| 5| 4| 3| 5| 3| 0| 8| 7| 4| 9| 1| 2| 3| 1| 6| 5| 0| 8| 8| 3| 8| 5| 5| |
| 2| 3| 7| 6| 7| 6| 5| 8| 3| 2| 4| 6| 4| 4| 3| 6| 2| 6| 6| 5| 1| 3| 5| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
170 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | | 1 4.0|
Epithelium, Hyperplasia, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Atrophy | 4 | 2 3.0|
Cyst | 4 | 1 4.0|
Degeneration | | 1 3.0|
Interstitial Cell, Hyperplasia | 2 2 2 2| 14 1.9|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 74 |
Hyperplasia | 3 3 2 3 | 14 2.8|
Hypoplasia | | 1 2.0|
Myelofibrosis, Focal | | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Axillary, Hemorrhage | 3 | 1 3.0|
Axillary, Hyperplasia, Lymphoid | | 1 3.0|
Iliac, Hyperplasia, Lymphoid | 3| 1 3.0|
Inguinal, Necrosis | | 1 4.0|
Mediastinal, Atrophy | 3 | 2 3.0|
Mediastinal, Congestion | | 3 3.3|
Mediastinal, Hemorrhage | 3 | 2 2.5|
Mediastinal, Hyperplasia, Lymphoid | 3 | 2 3.0|
Mediastinal, Pigmentation | | 2 3.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 74 |
Congestion | 2 | 2 2.5|
Hyperplasia, Lymphoid | | 1 3.0|
Hyperplasia, Reticulum Cell | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 73 |
Hyperplasia, Lymphoid | | 2 3.5|
Hyperplasia, Reticulum Cell | 3 2 | 6 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 74 |
Atrophy | 3 4 | 4 3.3|
Hematopoietic Cell Proliferation | 3 4 3 2 4 3 2 3 3 3 3 3 3 2 3 3| 43 3.0|
Hyperplasia, Reticulum Cell | 3 3 3 | 4 3.3|
Necrosis | | 1 3.0|
Pigmentation, Hemosiderin | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + M + M M + + M M + + + + + + + M + M + + M + + +| 55 |
Atrophy | | 1 2.0|
Edema | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 90
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
__________________________________________________________________________________________________________________________________
| 6| 6| 5| 5| 4| 5| 5| 5| 4| 4| 6| 5| 5| 4| 3| 6| 5| 5| 5| 4| 5| 5| 4| 4| 3| |
DAY ON TEST | 3| 0| 5| 4| 3| 5| 3| 0| 8| 7| 4| 9| 1| 2| 3| 1| 6| 5| 0| 8| 8| 3| 8| 5| 5| |
| 2| 3| 7| 6| 7| 6| 5| 8| 3| 2| 4| 6| 4| 4| 3| 6| 2| 6| 6| 5| 1| 3| 5| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
170 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + M + + + + + M + + + + + M + + + + + +| 68 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Abscess | | 1 3.0|
Acanthosis, Focal | 3 | 1 3.0|
Cyst Epithelial Inclusion | 2| 1 2.0|
Granuloma, Focal | | 1 4.0|
Hyperkeratosis, Focal | 4 4 | 2 4.0|
Dermis, Fibrosis, Focal | 2 | 2 2.5|
Hair Follicle, Hyperplasia, Basal | | |
Cell, Focal | | 1 3.0|
Subcutaneous Tissue, Edema | | 3 3.3|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + | 1 |
Cranium, Proliferation, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 3 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Cerebrum, Hemorrhage | | 2 1.5|
Cerebrum, Thrombosis, Multifocal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Congestion | | 1 3.0|
Edema | 3 | 1 3.0|
Hemorrhage | | 1 1.0|
Hyperplasia, Lymphoid | 2 2 2 2 1 2 2 1 2 2 2 2 2 3 2 2 2 1 2 2| 55 2.0|
Infiltration Cellular, Histiocyte | 2 3 3 2| 10 2.2|
Pigmentation, Focal | | 1 3.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 1 | 6 1.7|
Alveolar Epithelium, Hyperplasia, | | |
Multifocal | | 3 2.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 74 |
Fungus | 2 3 4 3 | 9 3.0|
Hyperkeratosis | 4 | 2 3.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 91
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
__________________________________________________________________________________________________________________________________
| 6| 6| 5| 5| 4| 5| 5| 5| 4| 4| 6| 5| 5| 4| 3| 6| 5| 5| 5| 4| 5| 5| 4| 4| 3| |
DAY ON TEST | 3| 0| 5| 4| 3| 5| 3| 0| 8| 7| 4| 9| 1| 2| 3| 1| 6| 5| 0| 8| 8| 3| 8| 5| 5| |
| 2| 3| 7| 6| 7| 6| 5| 8| 3| 2| 4| 6| 4| 4| 3| 6| 2| 6| 6| 5| 1| 3| 5| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
170 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Acute | 3 3 3 | 8 3.0|
Inflammation, Chronic | 4 | 2 3.0|
Necrosis, Focal | 2 4 | 2 3.0|
Necrosis, Multifocal | 3 | 1 3.0|
Mucosa, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + M | 3 |
Cataract | | 2 3.0|
Retina, Degeneration | 3 | 3 3.7|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Ectasia, Focal | | 1 2.0|
Ectasia | 3 3 2 2 2 3 3 2 2 2 4 2 3 3 3 2 2 3 | 53 2.2|
Hyperplasia, Focal | | 2 1.0|
Hyperplasia, Focal, Squamous | 1 1 2 1 1 1 1 1 | 10 1.4|
Hyperplasia, Squamous | | 1 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 74 |
Hydronephrosis | | 1 3.0|
Nephropathy, Chronic | 3 2 3 1 2 2 1 2 2 2 2 2 2 1 2 3 1 2 2| 58 2.0|
Thrombosis, Multifocal | X | 2 3.0|
Cortex, Infarct, Acute | 3 | 1 3.0|
Proximal Convoluted Renal Tubule, | | |
Necrosis, Diffuse | 4 | 1 4.0|
Renal Tubule, Mineralization | 3 | 2 3.5|
Renal Tubule, Pigmentation | 3 | 2 3.0|
Transitional Epithelium, Hyperplasia,| | |
Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 75 |
Hemorrhage | 3 | 3 3.7|
Inflammation, Acute | | 3 4.0|
Necrosis, Diffuse | | 2 4.0|
Necrosis, Focal | | 1 3.0|
Mucosa, Hyperplasia | 3 | 2 3.5|
Serosa, Cyst | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 92
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
_____________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 2| 5| 4| 4| 4| 3| 5| 5| 4| 4| 4|
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 9| 8| 2| 0| 7| 3| 8| 7| 4| 4| 9| 5| 8| 8| 2|
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 0| 6| 3| 1| 5| 7| 5| 8| 1| 4| 5| 0| 6| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
330 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Inflammation, Acute | |
__________________________________________________________________________|
Intestine Large | + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + A + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + M + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + M + + + + + + +|
Necrosis, Focal | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + +|
Basophilic Focus | 2 1 2 1 2 2 2 1 2 2 3 2 3 2|
Clear Cell Focus | 2 1 2 2 2 |
Degeneration, Cystic, Focal | 3 |
Degeneration, Cystic | 1 1 |
Degeneration, Cystic, Multifocal | 4 2 |
Eosinophilic Focus | 2 2 2 1 3 4 3 2 2|
Fatty Change | |
Granuloma | |
Hematopoietic Cell Proliferation | 1 2 2 1 1 2 1 1 2 2 2 2 2|
Hepatodiaphragmatic Nodule | |
Necrosis, Coagulative | |
Necrosis, Focal | 3 1 |
Necrosis, Multifocal | 3 3 |
Regeneration, Diffuse | |
Regeneration, Focal | 4 |
Regeneration, Multifocal | 3 4 |
Thrombosis | |
Vacuolization Cytoplasmic, Focal | 2 2 |
Vacuolization Cytoplasmic, Multifocal| |
Bile Duct, Hyperplasia | 3 |
Centrilobular, Degeneration, Diffuse | 4 1|
Centrilobular, Necrosis, Diffuse | 3 4 |
Centrilobular, Necrosis | |
Periportal, Fibrosis | |
Serosa, Inflammation, Acute | |
__________________________________________________________________________|
Mesentery | + + + |
Inflammation, Acute | |
Fat, Necrosis | 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + +|
Atrophy | 1 |
_____________________________________________________________________________________________________________________|
Page 93
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
_____________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 2| 5| 4| 4| 4| 3| 5| 5| 4| 4| 4|
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 9| 8| 2| 0| 7| 3| 8| 7| 4| 4| 9| 5| 8| 8| 2|
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 0| 6| 3| 1| 5| 7| 5| 8| 1| 4| 5| 0| 6| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
330 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Degeneration | |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + +|
Interlobular, Edema | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + +|
Acanthosis, Diffuse | 2 |
Acanthosis | 3 3 |
Ulcer | 3 |
Ulcer, Multifocal | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + +|
Hemorrhage, Focal | |
Necrosis, Focal | |
__________________________________________________________________________|
Tongue | + |
Hyperkeratosis, Focal | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 1 2 2 3 2 1 2 1 2 |
Inflammation, Acute, Multifocal | |
Atrium, Thrombosis | X X X X X 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + +|
Angiectasis, Multifocal | |
Infarct, Chronic | 4 |
Vacuolization Cytoplasmic, Diffuse | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 2 |
Hyperplasia, Multifocal | |
Infarct, Chronic | 4 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 2 |
Pars Intermedia, Cyst | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 94
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
_____________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 2| 5| 4| 4| 4| 3| 5| 5| 4| 4| 4|
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 9| 8| 2| 0| 7| 3| 8| 7| 4| 4| 9| 5| 8| 8| 2|
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 0| 6| 3| 1| 5| 7| 5| 8| 1| 4| 5| 0| 6| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
330 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + M + + + + + + +|
Atrophy | 3 |
Ectasia | 3 3 2 2 4 3 4 3 3 |
Hyperplasia, Focal | 2 1 |
Hyperplasia, Focal, Squamous | 1 |
Inflammation, Acute | 4 |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + +|
Hyperplasia, Focal, Glandular | 1 |
Inflammation, Chronic Active | 2 1 1 3 |
__________________________________________________________________________|
Seminal Vesicle | M + + M M + + + M + + + + + +|
Atrophy | 3 |
__________________________________________________________________________|
Testes | + + + + + + + M + + + + + + +|
Atrophy | |
Degeneration | 1 3 |
Interstitial Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + +|
Hyperplasia | |
Myelofibrosis, Focal | 2 |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + +|
Bronchial, Congestion | |
Inguinal, Hyperplasia, Lymphoid | |
Mediastinal, Congestion | |
Mediastinal, Hyperplasia, Lymphoid | |
Mediastinal, Pigmentation | 3 |
Pancreatic, Congestion | |
Pancreatic, Hyperplasia, Reticulum | |
Cell | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + +|
Congestion | |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + M + + + + + + +|
Congestion | |
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Reticulum Cell | 2 3 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Atrophy | |
Hematopoietic Cell Proliferation | 3 4 4 3 3 3 4 3 3 3 3|
_____________________________________________________________________________________________________________________|
Page 95
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
_____________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 2| 5| 4| 4| 4| 3| 5| 5| 4| 4| 4|
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 9| 8| 2| 0| 7| 3| 8| 7| 4| 4| 9| 5| 8| 8| 2|
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 0| 6| 3| 1| 5| 7| 5| 8| 1| 4| 5| 0| 6| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
330 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Megakaryocyte | 3 |
Hyperplasia, Reticulum Cell | 3 |
Metaplasia | |
Necrosis, Multifocal | |
__________________________________________________________________________|
Thymus | + + + M + + M + M + + + M + +|
Hemorrhage | 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + +|
Acanthosis, Focal | 4 |
Dermis, Fibrosis, Focal | 3 |
Dermis, Fibrosis | |
Hair Follicle, Hyperplasia, Basal | |
Cell, Focal | |
Prepuce, Hemorrhage | |
Subcutaneous Tissue, Edema | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + +|
Cerebellum, Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + +|
Congestion | |
Foreign Body | |
Hemorrhage | |
Hyperplasia, Lymphoid | 2 2 2 2 2 2 2 3 2 2 3 2 2 2|
Infiltration Cellular, Histiocyte | 2 |
Inflammation, Acute, Multifocal | |
Thrombosis | |
Thrombosis, Multiple | X|
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 |
Alveolar Epithelium, Hyperplasia, | |
Multifocal | |
Mediastinum, Inflammation, Acute | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + +|
Foreign Body | |
Fungus | |
_____________________________________________________________________________________________________________________|
Page 96
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
_____________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 2| 5| 4| 4| 4| 3| 5| 5| 4| 4| 4|
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 9| 8| 2| 0| 7| 3| 8| 7| 4| 4| 9| 5| 8| 8| 2|
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 0| 6| 3| 1| 5| 7| 5| 8| 1| 4| 5| 0| 6| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
330 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Hyperkeratosis | |
Inflammation, Acute | 2 |
Inflammation, Chronic | 3 |
Necrosis, Focal | 3 |
Glands, Hyperplasia | |
Nasolacrimal Duct, Inflammation, | |
Acute | |
Submucosa, Fibrosis | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Canal, Hyperplasia, Focal, Squamous | |
__________________________________________________________________________|
Eye | + |
Cornea, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + + + +|
Ectasia | 2 3 2 2 3 3 3 2 3 3 |
Hyperplasia, Focal | |
Hyperplasia, Focal, Squamous | 1 1 1 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + +|
Abscess, Multifocal | |
Infarct, Acute | |
Nephropathy, Chronic | 2 2 2 3 2 2 2 2 2 2 2 2 1 2|
Renal Tubule, Necrosis, Focal | |
Renal Tubule, Pigmentation | 3 |
Transitional Epithelium, Hyperplasia,| |
Focal | |
__________________________________________________________________________|
Urethra | |
Hyperplasia, Focal, Squamous | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + M + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 97
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
_____________________________________________________________________________________________________________________
| 5| 5| 5| 5| 3| 5| 5| 5| 5| 4| 5| 5| 5| 5| 2| 5| 5| 5| 4| 4| 5| 5| 5| 5| 4|
DAY ON TEST | 9| 6| 4| 4| 3| 6| 6| 5| 5| 1| 9| 6| 4| 1| 8| 6| 5| 2| 8| 0| 6| 4| 3| 2| 4|
| 7| 0| 6| 2| 9| 0| 0| 0| 0| 9| 2| 0| 2| 1| 4| 0| 1| 5| 3| 2| 0| 6| 4| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
330 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Inflammation, Acute | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + A + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + A + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + A + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + A + + + + + + +|
Necrosis, Focal | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 1 3 1 3 2 3 2 3 1 3 1 1 2 1 2 2 1 2|
Clear Cell Focus | 2 2 1 1 2 2 2 2 2 1 2 3 2 2|
Degeneration, Cystic, Focal | 3 |
Degeneration, Cystic | 1 1 1 2 1 2 2 1 3 2 |
Degeneration, Cystic, Multifocal | 2 3 |
Eosinophilic Focus | 2 2 3 3 3 2 2 3 4 2 3 3 2 3 2 1|
Fatty Change | 2 2|
Granuloma | 3 |
Hematopoietic Cell Proliferation | 2 2 1 1 1 1 2 3 1 1 2 2 1 2 1 1|
Hepatodiaphragmatic Nodule | |
Necrosis, Coagulative | |
Necrosis, Focal | 2 |
Necrosis, Multifocal | 3 2 2 |
Regeneration, Diffuse | 3 3 |
Regeneration, Focal | 2 4 |
Regeneration, Multifocal | 2 2 2 3 2 4 4 |
Thrombosis | X X 3 X |
Vacuolization Cytoplasmic, Focal | |
Vacuolization Cytoplasmic, Multifocal| 3 3 2 2 2 2 |
Bile Duct, Hyperplasia | 4 |
Centrilobular, Degeneration, Diffuse | 2 3 2 3 3 3 |
Centrilobular, Necrosis, Diffuse | |
Centrilobular, Necrosis | |
Periportal, Fibrosis | 4 |
Serosa, Inflammation, Acute | 3 |
__________________________________________________________________________|
Mesentery | + + + + + |
Inflammation, Acute | 4 |
Fat, Necrosis | 3 3 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
_____________________________________________________________________________________________________________________|
Page 98
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
_____________________________________________________________________________________________________________________
| 5| 5| 5| 5| 3| 5| 5| 5| 5| 4| 5| 5| 5| 5| 2| 5| 5| 5| 4| 4| 5| 5| 5| 5| 4|
DAY ON TEST | 9| 6| 4| 4| 3| 6| 6| 5| 5| 1| 9| 6| 4| 1| 8| 6| 5| 2| 8| 0| 6| 4| 3| 2| 4|
| 7| 0| 6| 2| 9| 0| 0| 0| 0| 9| 2| 0| 2| 1| 4| 0| 1| 5| 3| 2| 0| 6| 4| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
330 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Degeneration | |
__________________________________________________________________________|
Pharynx | + + + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interlobular, Edema | 3 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + A + + + + + + +|
Acanthosis, Diffuse | |
Acanthosis | |
Ulcer | |
Ulcer, Multifocal | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + A + + + + + + +|
Hemorrhage, Focal | 1 |
Necrosis, Focal | |
__________________________________________________________________________|
Tongue | + + + + + + |
Hyperkeratosis, Focal | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 2 2 3 2 2 2 2 2 2 1 2 3 2 1 2 3 2 1|
Inflammation, Acute, Multifocal | 2 |
Atrium, Thrombosis | X X X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Multifocal | 2 |
Infarct, Chronic | |
Vacuolization Cytoplasmic, Diffuse | 3 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 |
Hyperplasia, Multifocal | 1 2 2 |
Infarct, Chronic | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 99
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
_____________________________________________________________________________________________________________________
| 5| 5| 5| 5| 3| 5| 5| 5| 5| 4| 5| 5| 5| 5| 2| 5| 5| 5| 4| 4| 5| 5| 5| 5| 4|
DAY ON TEST | 9| 6| 4| 4| 3| 6| 6| 5| 5| 1| 9| 6| 4| 1| 8| 6| 5| 2| 8| 0| 6| 4| 3| 2| 4|
| 7| 0| 6| 2| 9| 0| 0| 0| 0| 9| 2| 0| 2| 1| 4| 0| 1| 5| 3| 2| 0| 6| 4| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
330 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 2 3 |
Ectasia | 4 4 4 3 2 3 3 |
Hyperplasia, Focal | 2 1 |
Hyperplasia, Focal, Squamous | 2 |
Inflammation, Acute | |
Inflammation, Chronic | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal, Glandular | |
Inflammation, Chronic Active | 3 3 3 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + M + + + + M + + + + M + + + + + + + + + M|
Atrophy | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 4 |
Degeneration | |
Interstitial Cell, Hyperplasia | 2 2 2 2 3 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 2 3 3 |
Myelofibrosis, Focal | 3 |
Myelofibrosis | 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + +|
Bronchial, Congestion | |
Inguinal, Hyperplasia, Lymphoid | 3 |
Mediastinal, Congestion | |
Mediastinal, Hyperplasia, Lymphoid | 3 |
Mediastinal, Pigmentation | |
Pancreatic, Congestion | |
Pancreatic, Hyperplasia, Reticulum | |
Cell | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hyperplasia, Lymphoid | 2 2 3 3|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + A + + + + + + + + + + + + + +|
Congestion | |
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Reticulum Cell | 4 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + A + + + + + + +|
Angiectasis, Focal | 3 3 |
Atrophy | 2 3 4 |
Hematopoietic Cell Proliferation | 4 3 4 2 4 3 3 3 4 3 3 2 3 3 3 3 |
_____________________________________________________________________________________________________________________|
Page 100
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
_____________________________________________________________________________________________________________________
| 5| 5| 5| 5| 3| 5| 5| 5| 5| 4| 5| 5| 5| 5| 2| 5| 5| 5| 4| 4| 5| 5| 5| 5| 4|
DAY ON TEST | 9| 6| 4| 4| 3| 6| 6| 5| 5| 1| 9| 6| 4| 1| 8| 6| 5| 2| 8| 0| 6| 4| 3| 2| 4|
| 7| 0| 6| 2| 9| 0| 0| 0| 0| 9| 2| 0| 2| 1| 4| 0| 1| 5| 3| 2| 0| 6| 4| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
330 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Megakaryocyte | |
Hyperplasia, Reticulum Cell | 3 3 4 3 |
Metaplasia | 2 |
Necrosis, Multifocal | 4 |
__________________________________________________________________________|
Thymus | + + + + + + + + M M + + + + + + + + + + M + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis, Focal | |
Dermis, Fibrosis, Focal | |
Dermis, Fibrosis | |
Hair Follicle, Hyperplasia, Basal | |
Cell, Focal | 2 2 3 |
Prepuce, Hemorrhage | |
Subcutaneous Tissue, Edema | 4 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebellum, Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Foreign Body | |
Hemorrhage | 2 |
Hyperplasia, Lymphoid | 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2|
Infiltration Cellular, Histiocyte | 2 2 4 |
Inflammation, Acute, Multifocal | |
Thrombosis | |
Thrombosis, Multiple | X |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
Alveolar Epithelium, Hyperplasia, | |
Multifocal | 2 1 2 |
Mediastinum, Inflammation, Acute | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Fungus | 3 4 |
_____________________________________________________________________________________________________________________|
Page 101
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
_____________________________________________________________________________________________________________________
| 5| 5| 5| 5| 3| 5| 5| 5| 5| 4| 5| 5| 5| 5| 2| 5| 5| 5| 4| 4| 5| 5| 5| 5| 4|
DAY ON TEST | 9| 6| 4| 4| 3| 6| 6| 5| 5| 1| 9| 6| 4| 1| 8| 6| 5| 2| 8| 0| 6| 4| 3| 2| 4|
| 7| 0| 6| 2| 9| 0| 0| 0| 0| 9| 2| 0| 2| 1| 4| 0| 1| 5| 3| 2| 0| 6| 4| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
330 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Hyperkeratosis | 2 |
Inflammation, Acute | 3 |
Inflammation, Chronic | 2 |
Necrosis, Focal | 3 |
Glands, Hyperplasia | |
Nasolacrimal Duct, Inflammation, | |
Acute | 3 |
Submucosa, Fibrosis | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Canal, Hyperplasia, Focal, Squamous | |
__________________________________________________________________________|
Eye | +|
Cornea, Inflammation, Chronic | |
__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 4 2 3 2 4 2 3 4 3 2 3 4 2 2 3 3 3 2 3|
Hyperplasia, Focal | 2 1 |
Hyperplasia, Focal, Squamous | 1 2 1 1 2|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess, Multifocal | 3 |
Infarct, Acute | 2 |
Nephropathy, Chronic | 3 1 2 2 2 1 1 1 3 1 2 2 2 2 2 2 2 2 1 2|
Renal Tubule, Necrosis, Focal | |
Renal Tubule, Pigmentation | 1 |
Transitional Epithelium, Hyperplasia,| |
Focal | |
__________________________________________________________________________|
Urethra | + |
Hyperplasia, Focal, Squamous | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 102
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
__________________________________________________________________________________________________________________________________
| 5| 5| 5| 4| 3| 5| 5| 4| 4| 4| 5| 5| 4| 4| 4| 5| 4| 4| 3| 3| | |
DAY ON TEST | 9| 8| 1| 1| 3| 6| 3| 8| 7| 2| 2| 0| 8| 7| 2| 4| 2| 0| 3| 0| | |
| 0| 5| 2| 4| 2| 1| 6| 5| 6| 3| 1| 6| 3| 7| 4| 1| 5| 1| 7| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | A |
330 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + | 60 |
Hyperkeratosis | 3 | 1 3.0|
Inflammation, Acute | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | 58 |
Parasite Metazoan | X X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + A + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + + + + + + + | 56 |
Necrosis, Focal | 4 | 1 4.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 60 |
Basophilic Focus | 2 3 1 1 2 2 1 2 3 2 2 2 1 2 2 2 2 | 49 1.9|
Clear Cell Focus | 2 3 1 1 1 1 1 1 2 | 28 1.7|
Degeneration, Cystic, Focal | 2 2 | 4 2.5|
Degeneration, Cystic | 1 2 1 | 15 1.5|
Degeneration, Cystic, Multifocal | 4 2 2 3 2 | 9 2.7|
Eosinophilic Focus | 2 2 3 3 2 3 2 2 4 2 4 2 2 | 38 2.5|
Fatty Change | 2 | 3 2.0|
Granuloma | 2 3 | 3 2.7|
Hematopoietic Cell Proliferation | 2 1 2 1 2 2 2 2 1 2 1 1 | 41 1.6|
Hepatodiaphragmatic Nodule | X X | 2 |
Necrosis, Coagulative | 3 | 1 3.0|
Necrosis, Focal | 2 2 | 5 2.0|
Necrosis, Multifocal | | 5 2.6|
Regeneration, Diffuse | 3 | 3 3.0|
Regeneration, Focal | 3 3 | 5 3.2|
Regeneration, Multifocal | 4 | 10 3.0|
Thrombosis | X 1 2 | 7 2.0|
Vacuolization Cytoplasmic, Focal | 3 | 3 2.3|
Vacuolization Cytoplasmic, Multifocal| 1 | 7 2.1|
Bile Duct, Hyperplasia | 2 2 | 4 2.8|
Centrilobular, Degeneration, Diffuse | 3 2 | 10 2.6|
Centrilobular, Necrosis, Diffuse | 3 3 4 | 5 3.4|
Centrilobular, Necrosis | 3 | 1 3.0|
Periportal, Fibrosis | | 1 4.0|
Serosa, Inflammation, Acute | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 103
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
__________________________________________________________________________________________________________________________________
| 5| 5| 5| 4| 3| 5| 5| 4| 4| 4| 5| 5| 4| 4| 4| 5| 4| 4| 3| 3| | |
DAY ON TEST | 9| 8| 1| 1| 3| 6| 3| 8| 7| 2| 2| 0| 8| 7| 2| 4| 2| 0| 3| 0| | |
| 0| 5| 2| 4| 2| 1| 6| 5| 6| 3| 1| 6| 3| 7| 4| 1| 5| 1| 7| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | A |
330 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Mesentery | + + + | 11 |
Inflammation, Acute | | 1 4.0|
Fat, Necrosis | 3 3 2 | 9 2.8|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 60 |
Atrophy | | 2 1.5|
Degeneration | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pharynx | + + + + | 7 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 60 |
Interlobular, Edema | | 1 3.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + | 57 |
Acanthosis, Diffuse | | 1 2.0|
Acanthosis | | 2 3.0|
Ulcer | 3 | 2 3.0|
Ulcer, Multifocal | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + | 58 |
Hemorrhage, Focal | | 1 1.0|
Necrosis, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Tongue | + + + | 10 |
Hyperkeratosis, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 60 |
Cardiomyopathy, Chronic | 2 2 2 2 2 2 2 1 2 3 3 2 2 2 | 42 2.0|
Inflammation, Acute, Multifocal | | 1 2.0|
Atrium, Thrombosis | X X X X X | 23 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + | 60 |
Angiectasis, Multifocal | | 1 2.0|
Infarct, Chronic | | 1 4.0|
Vacuolization Cytoplasmic, Diffuse | 2 | 4 2.3|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + | 60 |
Hyperplasia, Focal | 2 2 | 5 1.8|
Hyperplasia, Multifocal | 2 2 | 5 1.8|
Infarct, Chronic | | 1 4.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 104
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
__________________________________________________________________________________________________________________________________
| 5| 5| 5| 4| 3| 5| 5| 4| 4| 4| 5| 5| 4| 4| 4| 5| 4| 4| 3| 3| | |
DAY ON TEST | 9| 8| 1| 1| 3| 6| 3| 8| 7| 2| 2| 0| 8| 7| 2| 4| 2| 0| 3| 0| | |
| 0| 5| 2| 4| 2| 1| 6| 5| 6| 3| 1| 6| 3| 7| 4| 1| 5| 1| 7| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | A |
330 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 59 |
Pars Distalis, Cyst | | 1 2.0|
Pars Intermedia, Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 60 |
C-Cell, Hyperplasia, Focal | 2 | 2 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + | 59 |
Atrophy | 3 3 2 | 7 2.7|
Ectasia | 3 3 3 4 3 2 2 2 | 24 3.0|
Hyperplasia, Focal | 2 2 3 2 | 8 1.9|
Hyperplasia, Focal, Squamous | 2 2 | 4 1.8|
Inflammation, Acute | | 1 4.0|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + | 60 |
Hyperplasia, Focal, Glandular | 3 | 2 2.0|
Inflammation, Chronic Active | 3 2 2 | 11 2.3|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + M M + + + M M + + + + M + M M + M | 44 |
Atrophy | 3 | 2 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + | 59 |
Atrophy | 3 | 4 3.8|
Degeneration | | 2 2.0|
Interstitial Cell, Hyperplasia | 2 2 2 2 1 1 1 2 2 | 17 1.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 60 |
Hyperplasia | 3 3 | 7 2.9|
Myelofibrosis, Focal | | 2 2.5|
Myelofibrosis | 1 1 | 3 1.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + | 58 |
Bronchial, Congestion | 3 | 1 3.0|
Inguinal, Hyperplasia, Lymphoid | | 1 3.0|
Mediastinal, Congestion | 3 | 1 3.0|
Mediastinal, Hyperplasia, Lymphoid | 3 3 | 3 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 105
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
__________________________________________________________________________________________________________________________________
| 5| 5| 5| 4| 3| 5| 5| 4| 4| 4| 5| 5| 4| 4| 4| 5| 4| 4| 3| 3| | |
DAY ON TEST | 9| 8| 1| 1| 3| 6| 3| 8| 7| 2| 2| 0| 8| 7| 2| 4| 2| 0| 3| 0| | |
| 0| 5| 2| 4| 2| 1| 6| 5| 6| 3| 1| 6| 3| 7| 4| 1| 5| 1| 7| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | A |
330 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Mediastinal, Pigmentation | | 1 3.0|
Pancreatic, Congestion | 3 | 1 3.0|
Pancreatic, Hyperplasia, Reticulum | | |
Cell | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | 58 |
Congestion | 3 | 1 3.0|
Hyperplasia, Lymphoid | 2 | 6 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | 56 |
Congestion | 3 | 1 3.0|
Hyperplasia, Lymphoid | 3 | 3 3.0|
Hyperplasia, Reticulum Cell | 2 2 | 6 2.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 59 |
Angiectasis, Focal | | 2 3.0|
Atrophy | 3 | 4 3.0|
Hematopoietic Cell Proliferation | 3 4 3 4 3 3 2 3 3 4 3 | 38 3.2|
Hyperplasia, Megakaryocyte | | 1 3.0|
Hyperplasia, Reticulum Cell | 3 3 | 7 3.1|
Metaplasia | | 1 2.0|
Necrosis, Multifocal | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | M + M + + M + + + M M + + + + + + + + + | 48 |
Hemorrhage | | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + M + + + + + + M + + + + + | 56 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 60 |
Acanthosis, Focal | | 1 4.0|
Dermis, Fibrosis, Focal | | 1 3.0|
Dermis, Fibrosis | 3 | 1 3.0|
Hair Follicle, Hyperplasia, Basal | | |
Cell, Focal | | 3 2.3|
Prepuce, Hemorrhage | 3 | 1 3.0|
Subcutaneous Tissue, Edema | 3 | 3 3.3|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + | 6 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 106
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
__________________________________________________________________________________________________________________________________
| 5| 5| 5| 4| 3| 5| 5| 4| 4| 4| 5| 5| 4| 4| 4| 5| 4| 4| 3| 3| | |
DAY ON TEST | 9| 8| 1| 1| 3| 6| 3| 8| 7| 2| 2| 0| 8| 7| 2| 4| 2| 0| 3| 0| | |
| 0| 5| 2| 4| 2| 1| 6| 5| 6| 3| 1| 6| 3| 7| 4| 1| 5| 1| 7| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | A |
330 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Cerebellum, Hemorrhage | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 60 |
Congestion | | 1 3.0|
Foreign Body | 2 | 1 2.0|
Hemorrhage | | 1 2.0|
Hyperplasia, Lymphoid | 2 2 2 2 2 2 1 2 1 1 2 3 2 2 2 2 | 52 2.0|
Infiltration Cellular, Histiocyte | 2 2 | 6 2.3|
Inflammation, Acute, Multifocal | 4 | 1 4.0|
Thrombosis | 2 | 1 2.0|
Thrombosis, Multiple | | 2 |
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 1 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Multifocal | | 3 1.7|
Mediastinum, Inflammation, Acute | 4 | 1 4.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 60 |
Foreign Body | 3 | 1 3.0|
Fungus | 2 3 3 3 2 | 7 2.9|
Hyperkeratosis | | 1 2.0|
Inflammation, Acute | 3 2 | 4 2.5|
Inflammation, Chronic | 2 | 3 2.3|
Necrosis, Focal | | 2 3.0|
Glands, Hyperplasia | 2 | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Acute | | 1 3.0|
Submucosa, Fibrosis | | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + + | 2 |
Canal, Hyperplasia, Focal, Squamous | 3 | 1 3.0|
__________________________________________________________________________|____________|
Eye | | 2 |
Cornea, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + | 60 |
Ectasia | 2 2 2 3 2 2 2 3 2 2 2 | 40 2.6|
Hyperplasia, Focal | | 2 1.5|
Hyperplasia, Focal, Squamous | 1 1 1 | 12 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 107
NTP Experiment-Test: 05172-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 3,3-DIMETHOXYBENZIDINE DIHYDROCHLORIDE Date: 04/30/97
Route: DOSED WATER Time: 17:38:14
__________________________________________________________________________________________________________________________________
| 5| 5| 5| 4| 3| 5| 5| 4| 4| 4| 5| 5| 4| 4| 4| 5| 4| 4| 3| 3| | |
DAY ON TEST | 9| 8| 1| 1| 3| 6| 3| 8| 7| 2| 2| 0| 8| 7| 2| 4| 2| 0| 3| 0| | |
| 0| 5| 2| 4| 2| 1| 6| 5| 6| 3| 1| 6| 3| 7| 4| 1| 5| 1| 7| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | A |
330 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 60 |
Abscess, Multifocal | | 1 3.0|
Infarct, Acute | | 1 2.0|
Nephropathy, Chronic | 2 1 3 2 2 2 2 2 1 1 2 2 2 2 1 2 1 2 | 52 1.8|
Renal Tubule, Necrosis, Focal | 2 3 | 2 2.5|
Renal Tubule, Pigmentation | 1 | 3 1.7|
Transitional Epithelium, Hyperplasia,| | |
Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urethra | | 1 |
Hyperplasia, Focal, Squamous | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 59 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 108
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