TDMS Study 05186-04 Pathology Tables
NTP Experiment-Test: 05186-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY CARISOPRODOL Date: 04/06/98
Route: GAVAGE Time: 14:04:04
Facility: Battelle Columbus Laboratory
Chemical CAS #: 78-44-4
Lock Date: 04/13/93
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 05186-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY CARISOPRODOL Date: 04/06/98
Route: GAVAGE Time: 14:04:04
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B6C3F1 MICE FEMALE 0 MG/KG 600 1200 1600
MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10
Early Deaths
Dosing Accident 1 2
Natural Death 1
Survivors
Terminal Sacrifice 9 10 8 9
Animals Examined Microscopically 10 10 10 10
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ALIMENTARY SYSTEM
Liver (10) (10) (10) (10)
Inflammation, Granulomatous 2 (20%) 3 (30%) 3 (30%)
Centrilobular, Hypertrophy 8 (80%) 9 (90%)
Hepatocyte, Necrosis 1 (10%)
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CARDIOVASCULAR SYSTEM
Heart (1) (2) (1)
Epicardium, Foreign Body 1 (100%)
Epicardium, Inflammation, Suppurative 1 (100%) 1 (50%)
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ENDOCRINE SYSTEM
None
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
None
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HEMATOPOIETIC SYSTEM
Thymus (1) (2) (1)
Foreign Body 1 (100%)
Inflammation, Suppurative 1 (100%) 1 (50%)
Thymocyte, Autolysis 1 (50%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05186-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY CARISOPRODOL Date: 04/06/98
Route: GAVAGE Time: 14:04:04
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/KG 600 1200 1600
MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Thymocyte, Necrosis 1 (50%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
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MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (1) (2) (1)
Congestion, Acute 1 (50%)
Mediastinum, Foreign Body 1 (100%) 1 (50%)
Mediastinum, Inflammation, Suppurative 1 (100%) 2 (100%)
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SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05186-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY CARISOPRODOL Date: 04/06/98
Route: GAVAGE Time: 14:04:04
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/KG 600 1200 1600
MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10
Early Deaths
Dosing Accident 1 1 2
Natural Death 1
Survivors
Terminal Sacrifice 9 9 10 7
Animals Examined Microscopically 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (1) (1) (3)
Muscularis, Inflammation, Chronic Active 1 (100%)
Liver (10) (10) (10) (10)
Hematopoietic Cell Proliferation 1 (10%)
Inflammation, Granulomatous 1 (10%)
Centrilobular, Hypertrophy 9 (90%) 10 (100%) 7 (70%)
Salivary Glands (1) (1) (3)
Inflammation, Chronic Active 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (1) (1) (3)
Epicardium, Foreign Body 1 (100%)
Epicardium, Inflammation, Suppurative 1 (100%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
None
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05186-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY CARISOPRODOL Date: 04/06/98
Route: GAVAGE Time: 14:04:04
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/KG 600 1200 1600
MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Spleen (1) (1) (3)
Hematopoietic Cell Proliferation 1 (100%)
Thymus (1) (1) (3)
Inflammation, Granulomatous 1 (100%)
Thymocyte, Autolysis 3 (100%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (1) (1) (3)
Inflammation, Chronic Active 1 (100%)
Inflammation, Suppurative 1 (33%)
Mediastinum, Foreign Body 1 (100%) 1 (33%)
Mediastinum, Inflammation, Suppurative 2 (67%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (1) (10)
Inflammation, Chronic Active 1 (10%)
Renal Tubule, Regeneration 2 (20%) 2 (20%)
a Number of animals examined microscopically at site and number of animals with lesion
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