TDMS Study 05186-04 Pathology Tables

NTP Experiment-Test: 05186-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                    CARISOPRODOL                                       Date: 04/06/98
Route: GAVAGE                                                                                                     Time: 14:04:04
       Facility:  Battelle Columbus Laboratory
       Chemical CAS #:  78-44-4
       Lock Date:  04/13/93
       Cage Range:  All
       Reasons For Removal:    All
       Removal Date Range:     All
       Treatment Groups:       Include All
a  Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 05186-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                    CARISOPRODOL                                       Date: 04/06/98  
Route: GAVAGE                                                                                                     Time: 14:04:04  
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         B6C3F1 MICE FEMALE                        0 MG/KG      600          1200         1600                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          10           10           10           10                                     
  Early Deaths                                                                                                                      
    Dosing Accident                                    1                         2                                                  
    Natural Death                                                                             1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                 9           10            8            9                                     
  Animals Examined Microscopically                    10           10           10           10                                     
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 ALIMENTARY SYSTEM                                                                                                                  
   Liver                                              (10)         (10)         (10)         (10)                                   
      Inflammation, Granulomatous                      2 (20%)      3 (30%)      3 (30%)                                            
      Centrilobular, Hypertrophy                                                 8 (80%)      9 (90%)                               
      Hepatocyte, Necrosis                             1 (10%)                                                                      
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 CARDIOVASCULAR SYSTEM                                                                                                              
   Heart                                              (1)                       (2)          (1)                                    
      Epicardium, Foreign Body                         1 (100%)                                                                     
      Epicardium, Inflammation, Suppurative            1 (100%)                  1 (50%)                                            
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 ENDOCRINE SYSTEM                                                                                                                   
   None                                                                                                                             
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 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
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 GENITAL SYSTEM                                                                                                                     
   None                                                                                                                             
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 HEMATOPOIETIC SYSTEM                                                                                                               
   Thymus                                             (1)                       (2)          (1)                                    
      Foreign Body                                     1 (100%)                                                                     
      Inflammation, Suppurative                        1 (100%)                  1 (50%)                                            
      Thymocyte, Autolysis                                                       1 (50%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05186-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                    CARISOPRODOL                                       Date: 04/06/98  
Route: GAVAGE                                                                                                     Time: 14:04:04  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 MG/KG      600          1200         1600                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Thymocyte, Necrosis                                                        1 (50%)                                            
____________________________________________________________________________________________________________________________________
 INTEGUMENTARY SYSTEM                                                                                                               
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 MUSCULOSKELETAL SYSTEM                                                                                                             
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 NERVOUS SYSTEM                                                                                                                     
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 RESPIRATORY SYSTEM                                                                                                                 
   Lung                                               (1)                       (2)          (1)                                    
      Congestion, Acute                                                          1 (50%)                                            
      Mediastinum, Foreign Body                        1 (100%)                  1 (50%)                                            
      Mediastinum, Inflammation, Suppurative           1 (100%)                  2 (100%)                                           
____________________________________________________________________________________________________________________________________
 SPECIAL SENSES SYSTEM                                                                                                              
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 URINARY SYSTEM                                                                                                                     
   None                                                                                                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05186-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                    CARISOPRODOL                                       Date: 04/06/98  
Route: GAVAGE                                                                                                     Time: 14:04:04  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 MG/KG      600          1200         1600                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          10           10           10           10                                     
  Early Deaths                                                                                                                      
    Dosing Accident                                    1            1                         2                                     
    Natural Death                                                                             1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                 9            9           10            7                                     
  Animals Examined Microscopically                    10           10           10           10                                     
____________________________________________________________________________________________________________________________________
 ALIMENTARY SYSTEM                                                                                                                  
   Esophagus                                          (1)          (1)                       (3)                                    
      Muscularis, Inflammation, Chronic Active                      1 (100%)                                                        
   Liver                                              (10)         (10)         (10)         (10)                                   
      Hematopoietic Cell Proliferation                 1 (10%)                                                                      
      Inflammation, Granulomatous                      1 (10%)                                                                      
      Centrilobular, Hypertrophy                                    9 (90%)     10 (100%)     7 (70%)                               
   Salivary Glands                                    (1)          (1)                       (3)                                    
      Inflammation, Chronic Active                     1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
 CARDIOVASCULAR SYSTEM                                                                                                              
   Heart                                              (1)          (1)                       (3)                                    
      Epicardium, Foreign Body                         1 (100%)                                                                     
      Epicardium, Inflammation, Suppurative            1 (100%)                                                                     
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 ENDOCRINE SYSTEM                                                                                                                   
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 GENITAL SYSTEM                                                                                                                     
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05186-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                    CARISOPRODOL                                       Date: 04/06/98  
Route: GAVAGE                                                                                                     Time: 14:04:04  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 MG/KG      600          1200         1600                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
 HEMATOPOIETIC SYSTEM                                                                                                               
   Spleen                                             (1)          (1)                       (3)                                    
      Hematopoietic Cell Proliferation                 1 (100%)                                                                     
   Thymus                                             (1)          (1)                       (3)                                    
      Inflammation, Granulomatous                      1 (100%)                                                                     
      Thymocyte, Autolysis                                                                    3 (100%)                              
____________________________________________________________________________________________________________________________________
 INTEGUMENTARY SYSTEM                                                                                                               
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 MUSCULOSKELETAL SYSTEM                                                                                                             
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 NERVOUS SYSTEM                                                                                                                     
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 RESPIRATORY SYSTEM                                                                                                                 
   Lung                                               (1)          (1)                       (3)                                    
      Inflammation, Chronic Active                     1 (100%)                                                                     
      Inflammation, Suppurative                                                               1 (33%)                               
      Mediastinum, Foreign Body                        1 (100%)                               1 (33%)                               
      Mediastinum, Inflammation, Suppurative                                                  2 (67%)                               
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 SPECIAL SENSES SYSTEM                                                                                                              
   None                                                                                                                             
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 URINARY SYSTEM                                                                                                                     
   Kidney                                             (10)         (1)                       (10)                                   
      Inflammation, Chronic Active                     1 (10%)                                                                      
      Renal Tubule, Regeneration                       2 (20%)                                2 (20%)                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
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