TDMS Study 05217-04 Pathology Tables
NTP Experiment-Test: 05217-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96
Route: DOSED FEED Time: 08:12:00
Facility: Southern Research Institute
Chemical CAS #: 1948330
Lock Date: 05/26/93
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 05217-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96
Route: DOSED FEED Time: 08:12:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 0.5%
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 70 70
Scheduled Sacrifice 10 10
Early Deaths
Moribund Sacrifice 39 32
Natural Death 3 4
Survivors
Terminal Sacrifice 18 24
Animals Examined Microscopically 70 70
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Small, Duodenum (69) (69)
Intestine Small, Jejunum (70) (69)
Intestine Small, Ileum (70) (69)
Liver (70) (70)
Hepatocellular Adenoma 1 (1%)
Mesentery (8) (6)
Pancreas (70) (69)
Salivary Glands (70) (70)
Schwannoma Malignant 1 (1%)
Stomach, Forestomach (69) (69)
Squamous Cell Papilloma 2 (3%)
Stomach, Glandular (69) (70)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (70) (70)
Schwannoma Benign 1 (1%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (70) (70)
Adenoma 1 (1%)
Adrenal Medulla (67) (70)
Pheochromocytoma Malignant 1 (1%)
Pheochromocytoma Benign 3 (4%) 4 (6%)
Pheochromocytoma Benign, Multiple 1 (1%)
Islets, Pancreatic (70) (69)
Adenoma 1 (1%) 2 (3%)
Pituitary Gland (69) (70)
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NTP Experiment-Test: 05217-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96
Route: DOSED FEED Time: 08:12:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 0.5%
CONTROL
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Pars Distalis, Adenoma 30 (43%) 18 (26%)
Thyroid Gland (70) (69)
C-Cell, Adenoma 3 (4%) 6 (9%)
C-Cell, Carcinoma 1 (1%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (69) (69)
Adenoma 3 (4%) 10 (14%)
Carcinoma 2 (3%) 5 (7%)
Ovary (70) (70)
Granulosa Cell Tumor Malignant 1 (1%)
Granulosa Cell Tumor Benign 2 (3%) 1 (1%)
Uterus (70) (70)
Polyp Stromal 8 (11%) 6 (9%)
Sarcoma Stromal 1 (1%)
Vagina (1)
Squamous Cell Papilloma 1 (100%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (70) (70)
Lymph Node (19) (23)
Lymph Node, Mandibular (70) (69)
Lymph Node, Mesenteric (69) (69)
Spleen (70) (70)
Thymus (67) (69)
Thymoma Benign 1 (1%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (70) (69)
Carcinoma 1 (1%)
Fibroadenoma 22 (31%) 16 (23%)
Fibroadenoma, Multiple 8 (11%) 1 (1%)
Skin (70) (70)
Basal Cell Carcinoma 1 (1%)
Trichoepithelioma 1 (1%)
Subcutaneous Tissue, Fibroma 1 (1%) 1 (1%)
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NTP Experiment-Test: 05217-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96
Route: DOSED FEED Time: 08:12:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 0.5%
CONTROL
____________________________________________________________________________________________________________________________________
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (70) (70)
Astrocytoma Malignant 1 (1%)
Spinal Cord (4) (2)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (70) (70)
Alveolar/Bronchiolar Adenoma 2 (3%) 2 (3%)
Alveolar/Bronchiolar Carcinoma 1 (1%)
Nose (70) (70)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (70) (70)
Urinary Bladder (70) (70)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(70) *(70)
Leukemia Mononuclear 37 (53%) 34 (49%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
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NTP Experiment-Test: 05217-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96
Route: DOSED FEED Time: 08:12:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 0.5%
CONTROL
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 59 57
Total Primary Neoplasms 133 114
Total Animals with Benign Neoplasms 46 42
Total Benign Neoplasms 88 71
Total Animals with Malignant Neoplasms 40 41
Total Malignant Neoplasms 45 43
Total Animals with Metastatic Neoplasms
Total Metastatic Neoplasm
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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NTP Experiment-Test: 05217-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96
Route: DOSED FEED Time: 08:12:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 0.5%
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 70 70
Scheduled Sacrifice 10 10
Early Deaths
Natural Death 7 5
Moribund Sacrifice 43 33
Survivors
Terminal Sacrifice 10 22
Animals Examined Microscopically 70 70
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (70) (70)
Intestine Large, Cecum (70) (70)
Intestine Small, Duodenum (70) (70)
Intestine Small, Jejunum (70) (70)
Leiomyosarcoma 1 (1%)
Intestine Small, Ileum (70) (69)
Liver (70) (70)
Carcinoma, Metastatic, Thyroid Gland 1 (1%)
Mesentery (8) (5)
Hemangiosarcoma 1 (20%)
Oral Mucosa (2)
Carcinoma 1 (50%)
Squamous Cell Papilloma 1 (50%)
Pancreas (68) (70)
Acinus, Leiomyosarcoma, Metastatic, Stomach,
Forestomach 1 (1%)
Salivary Glands (70) (70)
Stomach, Forestomach (70) (70)
Leiomyosarcoma 1 (1%)
Squamous Cell Papilloma 3 (4%)
Stomach, Glandular (70) (70)
Tongue (1) (2)
Squamous Cell Carcinoma 1 (100%)
Squamous Cell Papilloma 1 (50%)
____________________________________________________________________________________________________________________________________
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NTP Experiment-Test: 05217-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96
Route: DOSED FEED Time: 08:12:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 0.5%
CONTROL
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (69) (70)
Heart (70) (70)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (70) (70)
Carcinoma, Metastatic, Thyroid Gland 1 (1%)
Osteosarcoma, Metastatic, Bone 1 (1%)
Adrenal Medulla (69) (70)
Pheochromocytoma Malignant 2 (3%) 2 (3%)
Pheochromocytoma Complex 1 (1%)
Pheochromocytoma Benign 7 (10%) 11 (16%)
Pheochromocytoma Benign, Multiple 5 (7%) 1 (1%)
Islets, Pancreatic (68) (70)
Adenoma 2 (3%) 5 (7%)
Adenoma, Multiple 1 (1%)
Pituitary Gland (67) (66)
Pars Distalis, Adenoma 13 (19%) 16 (24%)
Thyroid Gland (70) (69)
C-Cell, Adenoma 7 (10%) 5 (7%)
C-Cell, Adenoma, Multiple 1 (1%)
C-Cell, Carcinoma 5 (7%)
Follicular Cell, Carcinoma 2 (3%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Peritoneum (3) (3)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Preputial Gland (70) (69)
Adenoma 1 (1%) 1 (1%)
Carcinoma 1 (1%) 2 (3%)
Prostate (70) (70)
Seminal Vesicle (70) (70)
Testes (70) (70)
Bilateral, Interstitial Cell, Adenoma 52 (74%) 56 (80%)
Interstitial Cell, Adenoma 7 (10%) 4 (6%)
____________________________________________________________________________________________________________________________________
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NTP Experiment-Test: 05217-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96
Route: DOSED FEED Time: 08:12:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 0.5%
CONTROL
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (70) (70)
Lymph Node (36) (23)
Deep Cervical, Carcinoma, Metastatic,
Thyroid Gland 1 (3%) 1 (4%)
Lymph Node, Mandibular (70) (70)
Carcinoma, Metastatic, Thyroid Gland 1 (1%)
Lymph Node, Mesenteric (70) (70)
Spleen (70) (70)
Thymus (64) (67)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (68) (68)
Carcinoma 1 (1%) 1 (1%)
Fibroadenoma 4 (6%) 6 (9%)
Skin (70) (70)
Basal Cell Adenoma 1 (1%)
Basal Cell Carcinoma 1 (1%)
Keratoacanthoma 1 (1%) 1 (1%)
Sebaceous Gland, Adenoma 1 (1%)
Subcutaneous Tissue, Fibroma 6 (9%) 3 (4%)
Subcutaneous Tissue, Fibrosarcoma 1 (1%)
Subcutaneous Tissue, Schwannoma Malignant 1 (1%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (70) (70)
Osteosarcoma 2 (3%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (70) (70)
Astrocytoma Malignant 1 (1%)
Spinal Cord (2)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (70) (70)
Alveolar/Bronchiolar Adenoma 1 (1%) 1 (1%)
Alveolar/Bronchiolar Adenoma, Multiple 1 (1%)
Alveolar/Bronchiolar Carcinoma 1 (1%)
Carcinoma, Metastatic, Thyroid Gland 1 (1%) 1 (1%)
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NTP Experiment-Test: 05217-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96
Route: DOSED FEED Time: 08:12:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 0.5%
CONTROL
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont
Fibrosarcoma, Metastatic, Skin 1 (1%)
Leiomyosarcoma, Metastatic, Stomach,
Forestomach 1 (1%)
Osteosarcoma, Metastatic, Bone 1 (1%)
Nose (70) (70)
Squamous Cell Carcinoma 1 (1%)
Vomeronasal Organ, Adenoma 1 (1%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (70) (70)
Renal Tubule, Adenoma 1 (1%)
Transitional Epithelium, Carcinoma 1 (1%)
Urinary Bladder (70) (70)
Papilloma 1 (1%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(70) *(70)
Leukemia Mononuclear 46 (66%) 39 (56%)
Mesothelioma Malignant 3 (4%) 4 (6%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
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NTP Experiment-Test: 05217-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96
Route: DOSED FEED Time: 08:12:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 0.5%
CONTROL
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 59 60
Total Primary Neoplasms 166 187
Total Animals with Benign Neoplasms 59 60
Total Benign Neoplasms 107 122
Total Animals with Malignant Neoplasms 52 49
Total Malignant Neoplasms 59 65
Total Animals with Metastatic Neoplasms 1 4
Total Metastatic Neoplasm 5 7
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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