TDMS Study 93021-05 Pathology Tables
NTP Experiment-Test: 93021-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: 150-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97
Route: SKIN APPLICATION Time: 10:20:20
150 DAY SUBCHRONIC
Facility: Microbiological Associates
Chemical CAS #: 538-75-0
Lock Date: 03/26/96
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 93021-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: 150-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97
Route: SKIN APPLICATION Time: 10:20:20
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TG.AC HETEROZYGOUS TRANSGENIC MICE FEMALE 0 .75 1.5 3 6 12
MG/KG MG/KG MG/KG MG/KG MG/KG MG/KG
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DISPOSITION SUMMARY
Animals Initially in Study 10 10 10 10 10 10
Early Deaths
Moribund Sacrifice 2 2 2 2
Natural Death 1 1 1 1
Accidently Killed 1
Survivors
Terminal Sacrifice 7 7 10 6 8 9
Animals Examined Microscopically 10 10 10 10 10 10
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ALIMENTARY SYSTEM
Liver (10) (6) (6) (7) (10) (10)
Leukemia Erythrocytic 1 (10%) 2 (33%) 1 (10%)
Pancreas (10) (3) (4) (2) (10)
Leukemia Erythrocytic 1 (50%)
Stomach, Forestomach (10) (4) (2) (5) (4) (10)
Squamous Cell Papilloma 2 (50%) 2 (100%) 1 (20%) 1 (25%)
Tooth (4) (5) (6) (4) (5) (5)
Odontoma 3 (75%) 5 (100%) 6 (100%) 3 (75%) 5 (100%) 5 (100%)
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CARDIOVASCULAR SYSTEM
None
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ENDOCRINE SYSTEM
Thyroid Gland (9) (4) (4) (2) (10)
C-Cell, Adenoma 1 (25%)
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
None
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NTP Experiment-Test: 93021-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: 150-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97
Route: SKIN APPLICATION Time: 10:20:20
____________________________________________________________________________________________________________________________________
TG.AC HETEROZYGOUS TRANSGENIC MICE FEMALE 0 .75 1.5 3 6 12
MG/KG MG/KG MG/KG MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (1) (1)
Leukemia Erythrocytic 1 (100%)
Spleen (10) (5) (5) (4) (4) (10)
Leukemia Erythrocytic 2 (40%) 1 (25%)
Thymus (9) (3) (3) (2) (10)
Lymphoma Malignant 1 (11%)
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INTEGUMENTARY SYSTEM
Skin (10) (10) (10) (10) (10) (10)
Squamous Cell Papilloma 1 (10%) 1 (10%)
Skin, Site of Application, Squamous Cell
Carcinoma 1 (10%)
Skin, Site of Application, Squamous Cell
Papilloma 3 (30%) 3 (30%) 3 (30%)
Skin, Site of Application, Squamous Cell
Papilloma, Multiple 1 (10%) 3 (30%) 5 (50%)
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MUSCULOSKELETAL SYSTEM
None
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NERVOUS SYSTEM
None
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RESPIRATORY SYSTEM
None
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SPECIAL SENSES SYSTEM
None
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URINARY SYSTEM
None
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NTP Experiment-Test: 93021-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: 150-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97
Route: SKIN APPLICATION Time: 10:20:20
____________________________________________________________________________________________________________________________________
TG.AC HETEROZYGOUS TRANSGENIC MICE FEMALE 0 .75 1.5 3 6 12
MG/KG MG/KG MG/KG MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(10) *(10) *(10) *(10) *(10) *(10)
Leukemia Erythrocytic 1 (10%) 2 (20%) 1 (10%)
Lymphoma Malignant 1 (10%)
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* Number of animals with any tissue examined microscopically
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NTP Experiment-Test: 93021-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: 150-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97
Route: SKIN APPLICATION Time: 10:20:20
____________________________________________________________________________________________________________________________________
TG.AC HETEROZYGOUS TRANSGENIC MICE FEMALE 0 .75 1.5 3 6 12
MG/KG MG/KG MG/KG MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 5 6 9 6 8 10
Total Primary Neoplasms 5 8 12 7 14 14
Total Animals with Benign Neoplasms 3 6 8 6 8 10
Total Benign Neoplasms 3 8 10 7 12 14
Total Animals with Malignant Neoplasms 2 2 2
Total Malignant Neoplasms 2 2 2
Total Animals with Metastatic Neoplasms
Total Metastatic Neoplasm
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
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a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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