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TDMS Study 56111-03 Pathology Tables

NTP Experiment-Test: 56111-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 09/26/01
Route: DOSED FEED                                                                                                 Time: 15:19:28

                                                           FINAL/MICE




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  14371-10-9

       Lock Date:  06/01/00

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 56111-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 09/26/01    
Route: DOSED FEED                                                                                                 Time: 15:19:28    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     VEHICLE      .312%        .625%        1.25%                        
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50           50           50           50           50                        
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                11           10           13           10           10                        
    Natural Death                                      5            4            4            4            7                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                33           36           33           35           33                        
    Natural Death                                      1                                                                            
  Missing                                                                                     1                                     
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           49           50                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (50)         (50)         (49)         (50)                      
      Inflammation, Chronic                                                      1 (2%)                                             
   Intestine Large, Colon                             (50)         (50)         (50)         (49)         (50)                      
      Parasite Metazoan                                1 (2%)       5 (10%)                   4 (8%)       1 (2%)                   
   Intestine Large, Rectum                            (50)         (50)         (50)         (49)         (50)                      
      Parasite Metazoan                                             4 (8%)       1 (2%)       3 (6%)       1 (2%)                   
   Intestine Large, Cecum                             (50)         (49)         (50)         (49)         (50)                      
      Inflammation, Chronic Active                     1 (2%)                                                                       
   Intestine Small, Duodenum                          (50)         (50)         (50)         (49)         (50)                      
      Mineralization                                   1 (2%)                                                                       
      Parasite Metazoan                                                          1 (2%)                                             
   Intestine Small, Jejunum                           (50)         (50)         (50)         (49)         (50)                      
      Inflammation, Chronic Active                                               1 (2%)                                             
   Intestine Small, Ileum                             (50)         (50)         (50)         (49)         (50)                      
      Parasite Metazoan                                                                                    1 (2%)                   
   Liver                                              (50)         (50)         (50)         (49)         (50)                      
      Angiectasis                                      1 (2%)                                                                       
      Basophilic Focus                                42 (84%)     44 (88%)     42 (84%)     43 (88%)     44 (88%)                  
      Clear Cell Focus                                 1 (2%)       2 (4%)       2 (4%)                                             
      Eosinophilic Focus                                            1 (2%)                                 1 (2%)                   
      Fibrosis                                         1 (2%)                                              1 (2%)                   
      Hematopoietic Cell Proliferation                 3 (6%)       2 (4%)       3 (6%)                    1 (2%)                   
      Hepatodiaphragmatic Nodule                       4 (8%)       5 (10%)     12 (24%)      9 (18%)      7 (14%)                  
      Infarct                                          1 (2%)                                                                       
      Inflammation, Chronic Active                    44 (88%)     41 (82%)     42 (84%)     42 (86%)     43 (86%)                  
      Mixed Cell Focus                                26 (52%)     25 (50%)     24 (48%)     27 (55%)     20 (40%)                  
      Necrosis                                         5 (10%)      3 (6%)       4 (8%)       1 (2%)       6 (12%)                  
      Pigmentation                                                  1 (2%)       1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 56111-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 09/26/01    
Route: DOSED FEED                                                                                                 Time: 15:19:28    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     VEHICLE      .312%        .625%        1.25%                        
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Thrombosis                                                                 1 (2%)                                             
      Bile Duct, Hyperplasia                          21 (42%)     25 (50%)     28 (56%)     21 (43%)     18 (36%)                  
      Hepatocyte, Degeneration, Cystic                 1 (2%)       1 (2%)                                                          
      Hepatocyte, Hyperplasia                          1 (2%)       1 (2%)       2 (4%)                                             
      Hepatocyte, Vacuolization Cytoplasmic           31 (62%)     32 (64%)     25 (50%)     14 (29%)     18 (36%)                  
   Mesentery                                          (11)         (9)          (6)          (9)          (8)                       
      Hemorrhage                                                                                           1 (13%)                  
      Inflammation, Chronic                                                      1 (17%)                                            
      Fat, Inflammation, Chronic                       4 (36%)      8 (89%)      4 (67%)      8 (89%)      7 (88%)                  
      Fat, Mineralization                              8 (73%)      5 (56%)      2 (33%)      5 (56%)      3 (38%)                  
      Fat, Necrosis                                    9 (82%)      7 (78%)      5 (83%)      9 (100%)     7 (88%)                  
      Fat, Pigmentation                                                                                    1 (13%)                  
   Oral Mucosa                                        (12)         (11)         (24)         (18)         (5)                       
      Foreign Body                                    11 (92%)      9 (82%)     24 (100%)    17 (94%)      4 (80%)                  
      Gingival, Hyperplasia, Squamous                               1 (9%)                                                          
      Gingival, Inflammation, Chronic Active           5 (42%)      8 (73%)      8 (33%)      3 (17%)      1 (20%)                  
      Gingival, Necrosis                                                                                   1 (20%)                  
   Pancreas                                           (50)         (50)         (50)         (49)         (50)                      
      Basophilic Focus                                                                        1 (2%)                                
      Inflammation, Chronic Active                                                            2 (4%)       1 (2%)                   
      Acinus, Atrophy                                 12 (24%)     14 (28%)     14 (28%)      5 (10%)     11 (22%)                  
      Acinus, Hyperplasia                                           1 (2%)       1 (2%)                    1 (2%)                   
      Duct, Cyst                                                    8 (16%)      4 (8%)       4 (8%)       1 (2%)                   
   Salivary Glands                                    (50)         (50)         (49)         (49)         (50)                      
      Atrophy                                         11 (22%)     19 (38%)      8 (16%)      5 (10%)     11 (22%)                  
      Basophilic Focus                                10 (20%)      7 (14%)      6 (12%)      6 (12%)      3 (6%)                   
      Inflammation, Chronic Active                     1 (2%)       1 (2%)       2 (4%)                                             
      Mineralization                                                             1 (2%)                                             
      Vacuolization Cytoplasmic                                                               1 (2%)                                
   Stomach, Forestomach                               (50)         (50)         (50)         (49)         (50)                      
      Inflammation, Chronic Active                     1 (2%)                                 2 (4%)       1 (2%)                   
      Mineralization                                   1 (2%)                                                                       
      Epithelium, Hyperkeratosis                                                 2 (4%)       1 (2%)       1 (2%)                   
      Epithelium, Hyperplasia                          1 (2%)                    2 (4%)       2 (4%)                                
      Epithelium, Ulcer                                1 (2%)                                 2 (4%)                                
   Stomach, Glandular                                 (50)         (50)         (50)         (49)         (50)                      
      Inflammation, Chronic Active                                                            2 (4%)                                
      Mineralization                                   1 (2%)                                                                       
      Epithelium, Erosion                              2 (4%)                                              1 (2%)                   
      Epithelium, Hyperplasia                          1 (2%)                                                                       
      Epithelium, Ulcer                                                                       2 (4%)                                
      Glands, Ectasia                                 39 (78%)     36 (72%)     36 (72%)     39 (80%)     38 (76%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 56111-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 09/26/01    
Route: DOSED FEED                                                                                                 Time: 15:19:28    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     VEHICLE      .312%        .625%        1.25%                        
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (49)         (50)                      
      Cardiomyopathy                                  36 (72%)     45 (90%)     45 (90%)     43 (88%)     44 (88%)                  
      Mineralization                                   1 (2%)                    1 (2%)       1 (2%)                                
      Atrium, Thrombosis                               1 (2%)                                                                       
      Valve, Thrombosis                                                                       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (49)         (50)                      
      Accessory Adrenal Cortical Nodule                1 (2%)       2 (4%)       1 (2%)                    1 (2%)                   
      Angiectasis                                                   1 (2%)                                                          
      Hematopoietic Cell Proliferation                 2 (4%)       1 (2%)       5 (10%)      2 (4%)       1 (2%)                   
      Hyperplasia                                     10 (20%)     17 (34%)      9 (18%)     12 (24%)     10 (20%)                  
      Hypertrophy                                      1 (2%)       4 (8%)       2 (4%)       3 (6%)       2 (4%)                   
      Necrosis                                                      1 (2%)       2 (4%)       1 (2%)       1 (2%)                   
      Vacuolization Cytoplasmic                       20 (40%)     18 (36%)     25 (50%)     19 (39%)     20 (40%)                  
   Adrenal Medulla                                    (50)         (50)         (50)         (49)         (50)                      
      Hyperplasia                                      3 (6%)       6 (12%)      3 (6%)       3 (6%)       3 (6%)                   
   Islets, Pancreatic                                 (50)         (50)         (50)         (49)         (50)                      
      Hyperplasia                                                   1 (2%)                                                          
   Pituitary Gland                                    (50)         (50)         (50)         (49)         (50)                      
      Pars Distalis, Angiectasis                       2 (4%)       2 (4%)       3 (6%)       1 (2%)                                
      Pars Distalis, Cyst                             30 (60%)     27 (54%)     27 (54%)     19 (39%)     22 (44%)                  
      Pars Distalis, Hemorrhage                                                                            1 (2%)                   
      Pars Distalis, Hyperplasia                      24 (48%)     19 (38%)     21 (42%)     23 (47%)     21 (42%)                  
      Pars Distalis, Mineralization                                              1 (2%)                                             
      Pars Intermedia, Angiectasis                     1 (2%)                                                                       
      Pars Intermedia, Cyst                            2 (4%)                                                                       
      Pars Intermedia, Hyperplasia                     1 (2%)       1 (2%)                                                          
   Thyroid Gland                                      (50)         (50)         (49)         (49)         (50)                      
      Ectopic Thymus                                   1 (2%)                                                                       
      Inflammation, Chronic                                                      1 (2%)                                             
      Ultimobranchial Cyst                                                       1 (2%)       2 (4%)       1 (2%)                   
      C-Cell, Hyperplasia                             23 (46%)     33 (66%)     23 (47%)     28 (57%)     21 (42%)                  
      Follicle, Cyst                                                2 (4%)                    1 (2%)                                
      Follicular Cell, Hyperplasia                                               2 (4%)       1 (2%)       1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 56111-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 09/26/01    
Route: DOSED FEED                                                                                                 Time: 15:19:28    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     VEHICLE      .312%        .625%        1.25%                        
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (49)         (50)         (50)         (49)         (50)                      
      Hyperplasia                                     11 (22%)     11 (22%)     17 (34%)     11 (22%)      7 (14%)                  
      Inflammation, Chronic Active                    13 (27%)      9 (18%)     21 (42%)     15 (31%)     12 (24%)                  
      Mineralization                                   1 (2%)                                              1 (2%)                   
      Duct, Cyst                                      11 (22%)     16 (32%)      7 (14%)      9 (18%)     11 (22%)                  
   Ovary                                              (50)         (50)         (50)         (49)         (50)                      
      Angiectasis                                      1 (2%)                                                                       
      Atrophy                                                                    1 (2%)                                             
      Cyst                                             9 (18%)      5 (10%)      5 (10%)      4 (8%)       2 (4%)                   
      Mineralization                                                             1 (2%)       1 (2%)                                
      Granulosa Cell, Hyperplasia                                   1 (2%)                                                          
      Interstitial Cell, Hyperplasia                                             1 (2%)                                             
   Uterus                                             (50)         (50)         (50)         (49)         (50)                      
      Hemorrhage                                                                 1 (2%)                                             
      Hydrometra                                       2 (4%)       2 (4%)       5 (10%)      5 (10%)      3 (6%)                   
      Inflammation, Chronic Active                                               1 (2%)       1 (2%)                                
      Metaplasia, Squamous                             1 (2%)                                                                       
      Cervix, Cyst, Squamous                           1 (2%)                                                                       
      Cervix, Epithelium, Hyperplasia                               1 (2%)                                                          
      Endometrium, Hyperplasia, Cystic                 2 (4%)       5 (10%)      2 (4%)       4 (8%)       4 (8%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (49)         (50)                      
      Hyperplasia                                     15 (30%)     16 (32%)     13 (26%)     11 (22%)     13 (26%)                  
      Myelofibrosis                                    3 (6%)       2 (4%)       2 (4%)                    4 (8%)                   
   Lymph Node                                         (30)         (25)         (26)         (24)         (27)                      
      Deep Cervical, Ectasia                           1 (3%)                    1 (4%)       3 (13%)                               
      Deep Cervical, Hyperplasia, Lymphoid                                       1 (4%)       3 (13%)      3 (11%)                  
      Deep Cervical, Inflammation, Chronic                                       1 (4%)                                             
      Deep Cervical, Pigmentation                                                             1 (4%)                                
      Lumbar, Ectasia                                  1 (3%)                                                                       
      Mediastinal, Ectasia                            15 (50%)     17 (68%)     21 (81%)     20 (83%)     21 (78%)                  
      Mediastinal, Hyperplasia, Lymphoid              19 (63%)     20 (80%)     21 (81%)     20 (83%)     22 (81%)                  
      Mediastinal, Inflammation, Chronic                                         1 (4%)                                             
      Mediastinal, Pigmentation                        1 (3%)                    4 (15%)      1 (4%)       2 (7%)                   
   Lymph Node, Mandibular                             (1)          (2)                       (1)          (2)                       
      Ectasia                                          1 (100%)                                                                     
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 56111-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 09/26/01    
Route: DOSED FEED                                                                                                 Time: 15:19:28    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     VEHICLE      .312%        .625%        1.25%                        
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hyperplasia, Lymphoid                            1 (100%)                                                                     
   Lymph Node, Mesenteric                             (50)         (50)         (50)         (49)         (50)                      
      Ectasia                                          2 (4%)       1 (2%)                                                          
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
   Spleen                                             (50)         (50)         (49)         (49)         (50)                      
      Atrophy                                                       1 (2%)                                                          
      Hematopoietic Cell Proliferation                12 (24%)      5 (10%)      8 (16%)      3 (6%)       6 (12%)                  
      Hyperplasia, Lymphoid                            2 (4%)       1 (2%)                                 1 (2%)                   
      Infarct                                                       1 (2%)                                                          
      Pigmentation                                     1 (2%)       1 (2%)                                 2 (4%)                   
   Thymus                                             (43)         (49)         (47)         (48)         (47)                      
      Ectopic Parathyroid Gland                        4 (9%)       4 (8%)       3 (6%)       2 (4%)       6 (13%)                  
      Inflammation, Chronic Active                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (49)         (50)                      
      Cyst                                             5 (10%)      3 (6%)       3 (6%)       3 (6%)                                
      Cyst, Multiple                                                1 (2%)                                                          
      Hyperplasia, Cystic                             43 (86%)     47 (94%)     45 (90%)     37 (76%)     42 (84%)                  
   Skin                                               (50)         (50)         (50)         (49)         (50)                      
      Cyst Epithelial Inclusion                                                                            1 (2%)                   
      Fibrosis                                                      1 (2%)                                                          
      Inflammation, Chronic Active                                  1 (2%)                                 1 (2%)                   
      Epidermis, Hyperplasia                                        1 (2%)                                                          
      Epidermis, Ulcer                                              1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (49)         (50)                      
      Osteopetrosis                                                              1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (49)         (50)                      
      Compression                                      2 (4%)       3 (6%)       3 (6%)       2 (4%)       5 (10%)                  
      Hemorrhage                                       2 (4%)                                 2 (4%)       3 (6%)                   
      Hydrocephalus                                    2 (4%)       5 (10%)     10 (20%)      5 (10%)      8 (16%)                  
      Inflammation, Chronic Active                                                            1 (2%)                                
      Necrosis                                                                                             1 (2%)                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 56111-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 09/26/01    
Route: DOSED FEED                                                                                                 Time: 15:19:28    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     VEHICLE      .312%        .625%        1.25%                        
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NERVOUS SYSTEM - CONT                                                                                                               
      Meninges, Inflammation, Chronic Active                                                               1 (2%)                   
   Spinal Cord                                                                               (1)                                    
      Hemorrhage                                                                              1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (49)         (50)                      
      Congestion                                                                 1 (2%)                                             
      Fibrosis                                         1 (2%)                                              1 (2%)                   
      Inflammation, Chronic Active                    31 (62%)     36 (72%)     40 (80%)     37 (76%)     33 (66%)                  
      Metaplasia, Squamous                             1 (2%)                                                                       
      Mineralization                                  45 (90%)     45 (90%)     47 (94%)     45 (92%)     44 (88%)                  
      Pigmentation                                    44 (88%)     47 (94%)     44 (88%)     44 (90%)     44 (88%)                  
      Alveolar Epithelium, Hyperplasia                12 (24%)     12 (24%)     15 (30%)     13 (27%)      9 (18%)                  
      Alveolar Epithelium, Metaplasia, Focal,                                                                                       
          Squamous                                                  1 (2%)                                                          
      Alveolus, Infiltration Cellular, Histiocyte     44 (88%)     47 (94%)     44 (88%)     44 (90%)     45 (90%)                  
   Nose                                               (50)         (50)         (50)         (49)         (50)                      
      Foreign Body                                                                                         1 (2%)                   
      Inflammation, Chronic Active                     4 (8%)       1 (2%)                                 2 (4%)                   
      Thrombosis                                       2 (4%)       3 (6%)                    1 (2%)                                
      Nasolacrimal Duct, Inflammation, Suppurative     4 (8%)       5 (10%)      3 (6%)       6 (12%)      2 (4%)                   
   Trachea                                            (50)         (50)         (50)         (49)         (50)                      
      Inflammation, Chronic                                                      1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)                       (3)          (1)          (2)                       
      Lens, Cataract                                   1 (100%)                  3 (100%)                  2 (100%)                 
      Retina, Degeneration                             1 (100%)                  3 (100%)                  2 (100%)                 
      Retina, Hemorrhage                                                                      1 (100%)                              
   Zymbal's Gland                                     (1)                       (2)                                                 
      Cyst                                                                       1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (49)         (50)                      
      Accumulation, Hyaline Droplet                    1 (2%)                                                                       
      Atrophy                                                       1 (2%)                                                          
      Cyst                                             1 (2%)       1 (2%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
NTP Experiment-Test: 56111-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 09/26/01    
Route: DOSED FEED                                                                                                 Time: 15:19:28    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     VEHICLE      .312%        .625%        1.25%                        
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Hydronephrosis                                                1 (2%)                                                          
      Infarct                                                                    1 (2%)                    1 (2%)                   
      Infiltration Cellular, Lipocyte                                                                      1 (2%)                   
      Mineralization                                  30 (60%)     38 (76%)     28 (56%)     33 (67%)     30 (60%)                  
      Nephropathy                                     39 (78%)     43 (86%)     41 (82%)     38 (78%)     40 (80%)                  
      Pigmentation                                     1 (2%)       1 (2%)                                                          
      Pelvis, Inflammation, Suppurative                             1 (2%)                                                          
   Urinary Bladder                                    (50)         (50)         (50)         (49)         (50)                      
      Transitional Epithelium, Hyperplasia                                                    1 (2%)                                
      Transitional Epithelium, Metaplasia, Squamous                                           1 (2%)                                
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    8                                                              
                                                                                                                                   
NTP Experiment-Test: 56111-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 09/26/01    
Route: DOSED FEED                                                                                                 Time: 15:19:28    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     VEHICLE      .312%        .625%        1.25%                        
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50           50           50           50           50                        
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                14           13           11           11            6                        
    Natural Death                                      7            6            3           12            3                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                29           31           36           27           41                        
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50           50                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (50)         (50)         (50)         (50)         (50)                      
      Parasite Metazoan                                3 (6%)       4 (8%)       3 (6%)       1 (2%)       1 (2%)                   
   Intestine Large, Rectum                            (50)         (50)         (50)         (50)         (50)                      
      Parasite Metazoan                               10 (20%)      4 (8%)       5 (10%)      8 (16%)      4 (8%)                   
   Liver                                              (50)         (50)         (50)         (50)         (50)                      
      Angiectasis                                                   1 (2%)                    1 (2%)                                
      Basophilic Focus                                25 (50%)     26 (52%)     32 (64%)     23 (46%)     33 (66%)                  
      Clear Cell Focus                                 1 (2%)       1 (2%)                                 3 (6%)                   
      Eosinophilic Focus                               2 (4%)       1 (2%)                    2 (4%)                                
      Hematopoietic Cell Proliferation                 1 (2%)       1 (2%)                    2 (4%)                                
      Hepatodiaphragmatic Nodule                       2 (4%)       2 (4%)       1 (2%)       5 (10%)      4 (8%)                   
      Inflammation, Chronic Active                    34 (68%)     38 (76%)     38 (76%)     31 (62%)     39 (78%)                  
      Mixed Cell Focus                                18 (36%)     29 (58%)     32 (64%)     20 (40%)     32 (64%)                  
      Necrosis                                         2 (4%)       5 (10%)      2 (4%)       3 (6%)       5 (10%)                  
      Pigmentation                                                  1 (2%)                                                          
      Thrombosis                                                                 1 (2%)                                             
      Bile Duct, Cyst                                  1 (2%)       1 (2%)                                                          
      Bile Duct, Hyperplasia                          45 (90%)     46 (92%)     45 (90%)     43 (86%)     43 (86%)                  
      Hepatocyte, Degeneration, Cystic                 4 (8%)       7 (14%)      3 (6%)       4 (8%)       5 (10%)                  
      Hepatocyte, Hyperplasia                          1 (2%)       1 (2%)       1 (2%)       2 (4%)       1 (2%)                   
      Hepatocyte, Hypertrophy                                                                              1 (2%)                   
      Hepatocyte, Vacuolization Cytoplasmic           23 (46%)     37 (74%)     36 (72%)     32 (64%)     34 (68%)                  
      Portal, Fibrosis                                 1 (2%)                                                                       
   Mesentery                                          (14)         (5)          (8)          (9)          (12)                      
      Fat, Inflammation, Chronic                      11 (79%)      2 (40%)      3 (38%)      6 (67%)      9 (75%)                  
      Fat, Mineralization                              8 (57%)      2 (40%)      2 (25%)      5 (56%)      6 (50%)                  
      Fat, Necrosis                                   11 (79%)      2 (40%)      3 (38%)      8 (89%)     10 (83%)                  
   Oral Mucosa                                        (13)         (13)         (14)         (12)         (24)                      
      Foreign Body                                    13 (100%)    12 (92%)     12 (86%)     10 (83%)     22 (92%)                  
      Gingival, Inflammation, Chronic Active           9 (69%)      4 (31%)      9 (64%)      6 (50%)     12 (50%)                  
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    9                                                              
                                                                                                                                   
NTP Experiment-Test: 56111-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 09/26/01    
Route: DOSED FEED                                                                                                 Time: 15:19:28    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     VEHICLE      .312%        .625%        1.25%                        
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Pancreas                                           (50)         (50)         (50)         (50)         (50)                      
      Basophilic Focus                                              1 (2%)       2 (4%)                                             
      Inflammation, Chronic Active                                  1 (2%)       1 (2%)                    1 (2%)                   
      Metaplasia, Hepatocyte                                                     1 (2%)                                             
      Pigmentation                                                  1 (2%)                                                          
      Acinus, Atrophy                                 13 (26%)     25 (50%)     20 (40%)     23 (46%)     16 (32%)                  
      Acinus, Hyperplasia                                                        2 (4%)       1 (2%)                                
      Artery, Inflammation, Chronic Active                                                    1 (2%)                                
      Duct, Cyst                                       2 (4%)       3 (6%)       7 (14%)      3 (6%)      10 (20%)                  
   Salivary Glands                                    (50)         (50)         (50)         (50)         (50)                      
      Atrophy                                          8 (16%)      5 (10%)      7 (14%)      6 (12%)      1 (2%)                   
      Basophilic Focus                                16 (32%)     19 (38%)     10 (20%)     18 (36%)     24 (48%)                  
      Hyperplasia                                      1 (2%)                                                                       
      Inflammation, Chronic Active                                  1 (2%)                                 1 (2%)                   
   Stomach, Forestomach                               (50)         (50)         (50)         (50)         (50)                      
      Diverticulum                                     1 (2%)                                                                       
      Inflammation, Chronic Active                     4 (8%)       3 (6%)       1 (2%)       1 (2%)                                
      Mineralization                                                             1 (2%)                                             
      Epithelium, Hyperkeratosis                       2 (4%)       1 (2%)       2 (4%)       3 (6%)                                
      Epithelium, Hyperplasia                          5 (10%)      3 (6%)       3 (6%)       3 (6%)       1 (2%)                   
      Epithelium, Ulcer                                5 (10%)      2 (4%)       1 (2%)                                             
   Stomach, Glandular                                 (50)         (50)         (50)         (50)         (50)                      
      Inflammation, Chronic Active                     1 (2%)       2 (4%)       2 (4%)                    1 (2%)                   
      Mineralization                                   1 (2%)                                              1 (2%)                   
      Epithelium, Erosion                                           4 (8%)       2 (4%)                    1 (2%)                   
      Epithelium, Hyperplasia                                                    1 (2%)                                             
      Epithelium, Necrosis                                                       1 (2%)                                             
      Epithelium, Ulcer                                1 (2%)       1 (2%)                                 1 (2%)                   
      Glands, Ectasia                                 34 (68%)     34 (68%)     37 (74%)     27 (54%)     39 (78%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (50)         (50)         (50)         (50)                      
      Aorta, Mineralization                            1 (2%)       1 (2%)                                 1 (2%)                   
      Media, Mineralization                            1 (2%)                                                                       
   Heart                                              (50)         (50)         (50)         (50)         (50)                      
      Cardiomyopathy                                  44 (88%)     46 (92%)     46 (92%)     45 (90%)     50 (100%)                 
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Mineralization                                   1 (2%)                                 2 (4%)       1 (2%)                   
      Atrium, Thrombosis                               1 (2%)       3 (6%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   10                                                              
                                                                                                                                   
NTP Experiment-Test: 56111-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 09/26/01    
Route: DOSED FEED                                                                                                 Time: 15:19:28    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     VEHICLE      .312%        .625%        1.25%                        
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)         (50)                      
      Accessory Adrenal Cortical Nodule                1 (2%)                    2 (4%)       1 (2%)       2 (4%)                   
      Angiectasis                                                                             1 (2%)                                
      Atypia Cellular                                  1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 1 (2%)       2 (4%)       5 (10%)      2 (4%)       7 (14%)                  
      Hyperplasia                                     12 (24%)      9 (18%)     16 (32%)     14 (28%)     13 (26%)                  
      Hypertrophy                                      2 (4%)       3 (6%)       2 (4%)       1 (2%)       2 (4%)                   
      Mineralization                                                                          1 (2%)                                
      Necrosis                                                      2 (4%)                    3 (6%)       1 (2%)                   
      Vacuolization Cytoplasmic                       30 (60%)     27 (54%)     30 (60%)     33 (66%)     24 (48%)                  
   Adrenal Medulla                                    (50)         (50)         (50)         (50)         (50)                      
      Hyperplasia                                      8 (16%)      9 (18%)     14 (28%)      8 (16%)      5 (10%)                  
      Thrombosis                                                                 1 (2%)                                             
   Islets, Pancreatic                                 (50)         (50)         (50)         (50)         (50)                      
      Hyperplasia                                                   1 (2%)                                                          
   Pituitary Gland                                    (50)         (50)         (50)         (50)         (50)                      
      Pars Distalis, Angiectasis                                    1 (2%)                                 1 (2%)                   
      Pars Distalis, Cyst                              2 (4%)       4 (8%)       6 (12%)      3 (6%)       4 (8%)                   
      Pars Distalis, Hemorrhage                        1 (2%)                                                                       
      Pars Distalis, Hyperplasia                      16 (32%)     13 (26%)     16 (32%)     18 (36%)     21 (42%)                  
      Pars Distalis, Inflammation, Suppurative         1 (2%)                                                                       
      Pars Distalis, Mineralization                    1 (2%)                                                                       
      Pars Intermedia, Angiectasis                                                                         1 (2%)                   
      Pars Intermedia, Cyst                            2 (4%)       2 (4%)                    2 (4%)                                
      Pars Intermedia, Hyperplasia                                  1 (2%)                                                          
   Thyroid Gland                                      (50)         (50)         (50)         (50)         (50)                      
      Ultimobranchial Cyst                             3 (6%)       1 (2%)                    2 (4%)       2 (4%)                   
      C-Cell, Hyperplasia                             17 (34%)     22 (44%)     20 (40%)     15 (30%)     23 (46%)                  
      Follicle, Cyst                                   2 (4%)       2 (4%)       2 (4%)       2 (4%)       3 (6%)                   
      Follicular Cell, Hyperplasia                                  3 (6%)                                 2 (4%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (49)         (50)         (50)                      
      Granuloma Sperm                                  3 (6%)       1 (2%)       6 (12%)      4 (8%)       5 (10%)                  
      Inflammation, Chronic Active                     1 (2%)                                 2 (4%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   11                                                              
                                                                                                                                   
NTP Experiment-Test: 56111-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 09/26/01    
Route: DOSED FEED                                                                                                 Time: 15:19:28    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     VEHICLE      .312%        .625%        1.25%                        
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
   Preputial Gland                                    (50)         (50)         (49)         (50)         (50)                      
      Hyperplasia                                      7 (14%)                   2 (4%)       2 (4%)       3 (6%)                   
      Inflammation, Chronic, Diffuse, Suppurative                   1 (2%)                                                          
      Inflammation, Chronic Active                    49 (98%)     43 (86%)     47 (96%)     43 (86%)     49 (98%)                  
      Mineralization                                   2 (4%)                                              1 (2%)                   
      Duct, Ectasia                                    5 (10%)      7 (14%)      7 (14%)      6 (12%)      9 (18%)                  
   Prostate, NOS                                      (50)         (50)         (49)         (49)         (50)                      
      Cyst                                             1 (2%)       3 (6%)       1 (2%)       1 (2%)       1 (2%)                   
      Degeneration                                     1 (2%)                                                                       
      Inflammation, Chronic Active                    21 (42%)     23 (46%)     20 (41%)     20 (41%)     15 (30%)                  
      Mineralization                                   1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Epithelium, Hyperplasia                          2 (4%)       4 (8%)       1 (2%)       8 (16%)      6 (12%)                  
   Seminal Vesicle                                    (50)         (50)         (50)         (49)         (50)                      
      Inflammation, Chronic Active                                  1 (2%)       1 (2%)                                             
   Testes                                             (50)         (50)         (49)         (50)         (50)                      
      Atrophy                                          1 (2%)                                                                       
      Cyst                                                                                                 1 (2%)                   
      Mineralization                                  42 (84%)     38 (76%)     44 (90%)     36 (72%)     41 (82%)                  
      Germinal Epithelium, Atrophy                     4 (8%)       1 (2%)                    3 (6%)       2 (4%)                   
      Interstitial Cell, Hyperplasia                  10 (20%)      8 (16%)      4 (8%)       7 (14%)      3 (6%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)         (50)                      
      Hyperplasia                                     29 (58%)     33 (66%)     21 (42%)     26 (52%)     22 (44%)                  
      Myeloid Cell, Hyperplasia                                                  1 (2%)                                             
   Lymph Node                                         (24)         (20)         (28)         (28)         (20)                      
      Ectasia                                          2 (8%)                    1 (4%)                                             
      Hyperplasia, Lymphoid                            1 (4%)                                                                       
      Bronchial, Ectasia                                                         1 (4%)                                             
      Bronchial, Hyperplasia, Lymphoid                                           1 (4%)                                             
      Deep Cervical, Ectasia                           3 (13%)                   4 (14%)      4 (14%)      2 (10%)                  
      Deep Cervical, Hyperplasia, Lymphoid             3 (13%)      1 (5%)       4 (14%)      4 (14%)      3 (15%)                  
      Mediastinal, Ectasia                             6 (25%)     10 (50%)     11 (39%)     11 (39%)      7 (35%)                  
      Mediastinal, Hyperplasia, Lymphoid               7 (29%)     10 (50%)     10 (36%)     12 (43%)     12 (60%)                  
      Mediastinal, Pigmentation                                                  1 (4%)                                             
      Pancreatic, Ectasia                              1 (4%)                                                                       
   Lymph Node, Mandibular                             (2)                       (4)                                                 
      Ectasia                                          2 (100%)                  1 (25%)                                            
   Lymph Node, Mesenteric                             (50)         (50)         (50)         (49)         (50)                      
      Ectasia                                          2 (4%)                                 1 (2%)       1 (2%)                   
      Inflammation, Suppurative                                     1 (2%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   12                                                              
                                                                                                                                   
NTP Experiment-Test: 56111-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 09/26/01    
Route: DOSED FEED                                                                                                 Time: 15:19:28    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     VEHICLE      .312%        .625%        1.25%                        
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
   Spleen                                             (50)         (50)         (50)         (50)         (50)                      
      Congestion                                                                 2 (4%)                                             
      Fibrosis                                         1 (2%)                    3 (6%)                                             
      Hematopoietic Cell Proliferation                 2 (4%)       5 (10%)     10 (20%)      4 (8%)       6 (12%)                  
      Hyperplasia, Lymphoid                            3 (6%)       2 (4%)       2 (4%)       1 (2%)       5 (10%)                  
      Infarct                                                       1 (2%)       1 (2%)       1 (2%)                                
      Necrosis                                                      1 (2%)                                                          
      Pigmentation                                                  1 (2%)                                                          
      Lymphoid Follicle, Depletion Cellular                                      1 (2%)                                             
   Thymus                                             (43)         (44)         (45)         (46)         (43)                      
      Ectopic Parathyroid Gland                                     2 (5%)       1 (2%)       2 (4%)       2 (5%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (50)         (50)                      
      Cyst                                             1 (2%)                                                                       
      Hyperplasia, Cystic                             45 (90%)     47 (94%)     41 (82%)     45 (90%)     47 (94%)                  
      Inflammation, Chronic Active                     1 (2%)                                                                       
   Skin                                               (50)         (50)         (50)         (50)         (50)                      
      Hyperkeratosis                                   1 (2%)                    1 (2%)       1 (2%)                                
      Inflammation, Chronic Active                     1 (2%)                                 1 (2%)                                
      Inflammation, Granulomatous                                                1 (2%)                                             
      Dermis, Fibrosis                                                                        1 (2%)                                
      Epidermis, Hyperplasia                           1 (2%)                                 1 (2%)                                
      Hair Follicle, Sebaceous Gland, Atrophy                                                 1 (2%)                                
      Subcutaneous Tissue, Mineralization                                                     1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)         (50)                      
      Osteopetrosis                                                              1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)         (50)                      
      Compression                                      3 (6%)       2 (4%)       2 (4%)       3 (6%)       1 (2%)                   
      Hemorrhage                                       6 (12%)      1 (2%)       4 (8%)       2 (4%)       1 (2%)                   
      Hydrocephalus                                    4 (8%)       3 (6%)       3 (6%)       5 (10%)      2 (4%)                   
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Inflammation, Suppurative                        1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   13                                                              
                                                                                                                                   
NTP Experiment-Test: 56111-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 09/26/01    
Route: DOSED FEED                                                                                                 Time: 15:19:28    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     VEHICLE      .312%        .625%        1.25%                        
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NERVOUS SYSTEM - CONT                                                                                                               
      Mineralization                                   1 (2%)                                                                       
      Necrosis                                         3 (6%)                                                                       
      Pigmentation                                     1 (2%)                                                                       
      Thrombosis                                                                                           1 (2%)                   
   Spinal Cord                                        (1)          (1)                                                              
      Hemorrhage                                       1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)         (50)                      
      Fibrosis                                                                                             2 (4%)                   
      Hemorrhage                                                                 1 (2%)       1 (2%)                                
      Inflammation, Chronic Active                    26 (52%)     32 (64%)     31 (62%)     27 (54%)     36 (72%)                  
      Metaplasia, Osseous                                                                     1 (2%)                                
      Mineralization                                  45 (90%)     46 (92%)     47 (94%)     48 (96%)     49 (98%)                  
      Necrosis                                         1 (2%)                                                                       
      Pigmentation                                    30 (60%)     35 (70%)     32 (64%)     23 (46%)     35 (70%)                  
      Thrombosis                                                                 1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                 9 (18%)     10 (20%)     10 (20%)      9 (18%)     11 (22%)                  
      Alveolar Epithelium, Metaplasia, Focal,                                                                                       
          Squamous                                     1 (2%)                                                                       
      Alveolus, Infiltration Cellular, Histiocyte     31 (62%)     36 (72%)     32 (64%)     24 (48%)     35 (70%)                  
   Nose                                               (50)         (50)         (50)         (50)         (50)                      
      Foreign Body                                                  2 (4%)       1 (2%)       4 (8%)       3 (6%)                   
      Inflammation, Chronic Active                     2 (4%)       4 (8%)       2 (4%)       3 (6%)       4 (8%)                   
      Keratin Cyst                                     1 (2%)                                                                       
      Polyp Inflammatory                                                                                   1 (2%)                   
      Thrombosis                                       1 (2%)       2 (4%)       3 (6%)       6 (12%)      2 (4%)                   
      Nasolacrimal Duct, Inflammation, Suppurative    12 (24%)      6 (12%)      4 (8%)       5 (10%)      9 (18%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)          (1)          (2)          (1)                                    
      Cornea, Inflammation, Chronic Active                                       1 (50%)                                            
      Cornea, Inflammation, Suppurative                                          1 (50%)                                            
      Lens, Cataract                                   1 (50%)      1 (100%)     1 (50%)      1 (100%)                              
      Lens, Degeneration                               1 (50%)                                                                      
      Retina, Degeneration                             2 (100%)     1 (100%)                  1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                             Page   14                                                              
                                                                                                                                   
NTP Experiment-Test: 56111-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 09/26/01    
Route: DOSED FEED                                                                                                 Time: 15:19:28    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     VEHICLE      .312%        .625%        1.25%                        
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)         (50)                      
      Accumulation, Hyaline Droplet                                 1 (2%)       1 (2%)                                             
      Atrophy                                                                                              1 (2%)                   
      Cyst                                                          1 (2%)                                 1 (2%)                   
      Hydronephrosis                                   1 (2%)                                                                       
      Infarct                                                                    1 (2%)       2 (4%)                                
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Inflammation, Suppurative                                                                            1 (2%)                   
      Metaplasia, Osseous                                                                                  1 (2%)                   
      Mineralization                                  38 (76%)     31 (62%)     30 (60%)     32 (64%)     38 (76%)                  
      Necrosis                                                      1 (2%)                                 1 (2%)                   
      Nephropathy                                     47 (94%)     47 (94%)     49 (98%)     44 (88%)     45 (90%)                  
      Cortex, Medulla, Fibrosis                                     1 (2%)                                                          
      Cortex, Medulla, Pigmentation                                 1 (2%)                                                          
      Cortex, Medulla, Pelvis, Cyst                                 1 (2%)                                                          
      Medulla, Necrosis                                1 (2%)                                                                       
      Medulla, Renal Tubule, Dilatation                             1 (2%)                                                          
   Urinary Bladder                                    (50)         (50)         (49)         (49)         (50)                      
      Hemorrhage                                       1 (2%)                    1 (2%)                                             
      Inflammation, Chronic Active                     1 (2%)                                                                       
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   15                                                              
                                                                                                                                   
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
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