TDMS Study 56111-03 Pathology Tables
NTP Experiment-Test: 56111-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:35:47
FINAL #1
Facility: Battelle Columbus Laboratory
Chemical CAS #: 14371-10-9
Lock Date: 06/01/00
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 56111-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:35:47
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD VEHICLE .312% .625% 1.25%
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50 50
Early Deaths
Moribund Sacrifice 11 10 13 10 10
Natural Death 5 4 4 4 7
Survivors
Terminal Sacrifice 33 36 33 35 33
Natural Death 1
Missing 1
Animals Examined Microscopically 50 50 50 49 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (50) (50) (49) (50)
Lipoma 1 (2%)
Intestine Large, Colon (50) (50) (50) (49) (50)
Intestine Small, Duodenum (50) (50) (50) (49) (50)
Intestine Small, Jejunum (50) (50) (50) (49) (50)
Carcinoma 1 (2%)
Leiomyosarcoma 1 (2%)
Intestine Small, Ileum (50) (50) (50) (49) (50)
Liver (50) (50) (50) (49) (50)
Cholangiocarcinoma 1 (2%)
Mesentery (11) (9) (6) (9) (8)
Pancreas (50) (50) (50) (49) (50)
Salivary Glands (50) (50) (49) (49) (50)
Stomach, Forestomach (50) (50) (50) (49) (50)
Stomach, Glandular (50) (50) (50) (49) (50)
Tongue (1) (1)
Squamous Cell Papilloma 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (49) (50)
Hemangiosarcoma 1 (2%)
Schwannoma Malignant 1 (2%)
Squamous Cell Carcinoma, Metastatic, Lung 1 (2%)
Thymoma Malignant, Metastatic, Thymus 1 (2%)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 56111-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:35:47
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD VEHICLE .312% .625% 1.25%
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (49) (50)
Adenoma 1 (2%)
Chondrosarcoma, Metastatic, Bone 1 (2%)
Adrenal Medulla (50) (50) (50) (49) (50)
Chondrosarcoma, Metastatic, Bone 1 (2%)
Pheochromocytoma Malignant 1 (2%) 1 (2%)
Pheochromocytoma Complex 1 (2%) 1 (2%)
Pheochromocytoma Benign 2 (4%)
Bilateral, Pheochromocytoma Benign 1 (2%)
Islets, Pancreatic (50) (50) (50) (49) (50)
Adenoma 1 (2%) 2 (4%)
Carcinoma 2 (4%)
Pituitary Gland (50) (50) (50) (49) (50)
Pars Distalis, Adenoma 19 (38%) 16 (32%) 17 (34%) 15 (31%) 17 (34%)
Pars Distalis, Adenoma, Multiple 1 (2%)
Thyroid Gland (50) (50) (49) (49) (50)
C-Cell, Adenoma 5 (10%) 6 (12%) 3 (6%) 4 (8%) 5 (10%)
C-Cell, Carcinoma 3 (6%) 3 (6%)
Follicular Cell, Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (49) (50) (50) (49) (50)
Adenoma 3 (6%) 4 (8%) 1 (2%) 2 (4%)
Carcinoma 3 (6%) 6 (12%) 1 (2%) 2 (4%) 2 (4%)
Bilateral, Adenoma 1 (2%)
Ovary (50) (50) (50) (49) (50)
Cystadenoma 1 (2%)
Granulosa Cell Tumor Benign 1 (2%)
Uterus (50) (50) (50) (49) (50)
Leiomyoma 1 (2%)
Polyp Stromal 6 (12%) 7 (14%) 5 (10%) 8 (16%) 12 (24%)
Polyp Stromal, Multiple 3 (6%)
Bilateral, Polyp Stromal 1 (2%)
Endometrium, Carcinoma 1 (2%)
Page 3
NTP Experiment-Test: 56111-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:35:47
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD VEHICLE .312% .625% 1.25%
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (49) (50)
Lymph Node (30) (25) (26) (24) (27)
Deep Cervical, Carcinoma, Metastatic,
Thyroid Gland 1 (3%)
Mediastinal, Carcinoma, Metastatic, Thyroid
Gland 2 (7%)
Lymph Node, Mandibular (1) (2) (1) (2)
Lymph Node, Mesenteric (50) (50) (50) (49) (50)
Spleen (50) (50) (49) (49) (50)
Thymus (43) (49) (47) (48) (47)
Thymoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (49) (50)
Adenolipoma 1 (2%)
Adenoma, Multiple 1 (2%)
Carcinoma 1 (2%) 3 (6%)
Fibroadenoma 17 (34%) 22 (44%) 18 (36%) 16 (33%) 16 (32%)
Fibroadenoma, Multiple 8 (16%) 8 (16%) 9 (18%) 5 (10%) 5 (10%)
Skin (50) (50) (50) (49) (50)
Basal Cell Carcinoma 1 (2%)
Keratoacanthoma 2 (4%) 1 (2%)
Neural Crest Tumor 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%)
Subcutaneous Tissue, Lipoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (49) (50)
Chondrosarcoma 1 (2%)
Osteosarcoma 1 (2%)
Skeletal Muscle (1) (1) (1)
Chondrosarcoma, Metastatic, Bone 1 (100%)
Lipoma 1 (100%)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 56111-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:35:47
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD VEHICLE .312% .625% 1.25%
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (49) (50)
Astrocytoma Malignant 1 (2%)
Spinal Cord (1)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (49) (50)
Alveolar/Bronchiolar Adenoma 2 (4%) 4 (8%) 2 (4%) 2 (4%) 2 (4%)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Chondrosarcoma, Metastatic, Bone 1 (2%)
Pheochromocytoma Complex, Metastatic,
Adrenal Medulla 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Carcinoma, Metastatic, Lung 1 (2%)
Thymoma Malignant, Metastatic, Thymus 1 (2%)
Mediastinum, Squamous Cell Carcinoma,
Metastatic, Lung 1 (2%)
Nose (50) (50) (50) (49) (50)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1) (2)
Adenoma 1 (100%)
Carcinoma 1 (50%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (49) (50)
Renal Tubule, Adenoma 1 (2%)
Urinary Bladder (50) (50) (50) (49) (50)
Page 5
NTP Experiment-Test: 56111-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:35:47
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD VEHICLE .312% .625% 1.25%
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(49) *(50)
Adenolipoma 1 (2%)
Leukemia Mononuclear 9 (18%) 12 (24%) 8 (16%) 7 (14%) 9 (18%)
Lymphoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 6
NTP Experiment-Test: 56111-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:35:47
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD VEHICLE .312% .625% 1.25%
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 45 47 42 44 42
Total Primary Neoplasms 89 90 87 71 76
Total Animals with Benign Neoplasms 39 39 37 38 38
Total Benign Neoplasms 64 69 71 54 63
Total Animals with Malignant Neoplasms 21 18 14 16 13
Total Malignant Neoplasms 24 21 16 17 13
Total Animals with Metastatic Neoplasms 6 1 1
Total Metastatic Neoplasm 10 4 1
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1
Total Uncertain Neoplasms 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 7
NTP Experiment-Test: 56111-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:35:47
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD VEHICLE .312% .625% 1.25%
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50 50
Early Deaths
Moribund Sacrifice 14 13 11 11 6
Natural Death 7 6 3 12 3
Survivors
Terminal Sacrifice 29 31 36 27 41
Animals Examined Microscopically 50 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (50) (50) (50) (50)
Intestine Large, Colon (50) (50) (50) (50) (50)
Intestine Large, Cecum (50) (50) (50) (50) (50)
Intestine Small, Duodenum (50) (50) (50) (50) (50)
Intestine Small, Jejunum (50) (50) (50) (50) (50)
Leiomyosarcoma 1 (2%)
Intestine Small, Ileum (50) (50) (50) (50) (50)
Liver (50) (50) (50) (50) (50)
Cholangiocarcinoma 1 (2%)
Fibrous Histiocytoma, Metastatic, Skin 2 (4%) 1 (2%) 1 (2%)
Hepatocellular Adenoma 1 (2%) 1 (2%) 1 (2%)
Osteosarcoma, Metastatic, Uncertain Primary
Site 1 (2%)
Rhabdomyosarcoma, Metastatic, Skeletal Muscle 1 (2%)
Mesentery (14) (5) (8) (9) (12)
Fibrous Histiocytoma, Metastatic, Skin 1 (13%)
Lipoma 1 (20%) 1 (8%)
Osteosarcoma, Metastatic, Uncertain Primary
Site 1 (20%)
Rhabdomyosarcoma, Metastatic, Skeletal Muscle 1 (13%)
Oral Mucosa (13) (13) (14) (12) (24)
Gingival, Squamous Cell Carcinoma 1 (8%) 1 (8%)
Pancreas (50) (50) (50) (50) (50)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
Mixed Tumor Benign 1 (2%)
Osteosarcoma, Metastatic, Uncertain Primary
Site 1 (2%)
Rhabdomyosarcoma, Metastatic, Skeletal Muscle 1 (2%)
Acinus, Adenoma 1 (2%) 1 (2%)
Page 8
NTP Experiment-Test: 56111-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:35:47
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD VEHICLE .312% .625% 1.25%
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont
Salivary Glands (50) (50) (50) (50) (50)
Carcinoma 1 (2%)
Stomach, Forestomach (50) (50) (50) (50) (50)
Rhabdomyosarcoma, Metastatic, Skeletal Muscle 1 (2%)
Squamous Cell Papilloma 1 (2%)
Stomach, Glandular (50) (50) (50) (50) (50)
Tongue (1) (1)
Squamous Cell Papilloma 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50) (50)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
Schwannoma Malignant 2 (4%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50) (50)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
Adrenal Medulla (50) (50) (50) (50) (50)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
Ganglioneuroma 1 (2%)
Pheochromocytoma Benign 5 (10%) 3 (6%) 4 (8%)
Bilateral, Pheochromocytoma Benign 1 (2%)
Islets, Pancreatic (50) (50) (50) (50) (50)
Adenoma 1 (2%) 1 (2%) 1 (2%)
Carcinoma 1 (2%)
Parathyroid Gland (47) (45) (48) (46) (42)
Adenoma 2 (4%)
Pituitary Gland (50) (50) (50) (50) (50)
Carcinoma, Metastatic, Salivary Glands 1 (2%)
Pars Distalis, Adenoma 13 (26%) 8 (16%) 10 (20%) 10 (20%) 8 (16%)
Thyroid Gland (50) (50) (50) (50) (50)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
Bilateral, C-Cell, Adenoma 1 (2%) 1 (2%)
Bilateral, C-Cell, Carcinoma 1 (2%)
C-Cell, Adenoma 4 (8%) 7 (14%) 9 (18%) 3 (6%) 10 (20%)
C-Cell, Carcinoma 1 (2%) 2 (4%) 1 (2%) 1 (2%)
Follicular Cell, Adenoma 1 (2%)
Follicular Cell, Carcinoma 1 (2%) 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
Page 9
NTP Experiment-Test: 56111-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:35:47
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD VEHICLE .312% .625% 1.25%
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Peritoneum (1) (1) (1)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (49) (50) (50)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
Preputial Gland (50) (50) (49) (50) (50)
Adenoma 2 (4%) 5 (10%) 1 (2%) 2 (4%)
Carcinoma 3 (6%) 1 (2%) 2 (4%) 3 (6%) 1 (2%)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
Prostate (50) (50) (49) (49) (50)
Adenoma 4 (8%)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
Seminal Vesicle (50) (50) (50) (49) (50)
Testes (50) (50) (49) (50) (50)
Bilateral, Interstitial Cell, Adenoma 34 (68%) 39 (78%) 44 (90%) 35 (70%) 47 (94%)
Interstitial Cell, Adenoma 11 (22%) 7 (14%) 3 (6%) 7 (14%) 3 (6%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50) (50)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
Lymph Node (24) (20) (28) (28) (20)
Deep Cervical, Carcinoma, Metastatic,
Thyroid Gland 1 (4%) 1 (5%)
Mediastinal, Carcinoma, Metastatic, Thyroid
Gland 1 (5%)
Mediastinal, Fibrous Histiocytoma,
Metastatic, Skin 1 (4%)
Pancreatic, Fibrous Histiocytoma, Metastatic,
Skin 1 (4%)
Lymph Node, Mandibular (2) (4)
Lymph Node, Mesenteric (50) (50) (50) (49) (50)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
Osteosarcoma, Metastatic, Uncertain Primary
Site 1 (2%)
Spleen (50) (50) (50) (50) (50)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
Rhabdomyosarcoma, Metastatic, Skeletal Muscle 1 (2%)
Page 10
NTP Experiment-Test: 56111-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:35:47
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD VEHICLE .312% .625% 1.25%
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Thymus (43) (44) (45) (46) (43)
Thymoma Benign 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50) (50)
Fibroadenoma 2 (4%) 1 (2%) 2 (4%) 2 (4%) 1 (2%)
Skin (50) (50) (50) (50) (50)
Basal Cell Adenoma 1 (2%)
Basal Cell Carcinoma 1 (2%) 1 (2%)
Keratoacanthoma 2 (4%) 2 (4%) 2 (4%) 3 (6%)
Keratoacanthoma, Multiple 1 (2%) 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Trichoepithelioma 1 (2%) 3 (6%)
Sebaceous Gland, Adenoma 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%) 5 (10%) 2 (4%) 4 (8%)
Subcutaneous Tissue, Fibroma, Multiple 1 (2%) 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 4 (8%) 2 (4%) 1 (2%) 1 (2%)
Subcutaneous Tissue, Fibrous Histiocytoma 2 (4%) 1 (2%) 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50) (50)
Osteosarcoma 1 (2%)
Rhabdomyosarcoma, Metastatic, Skeletal Muscle 1 (2%)
Skeletal Muscle (2) (1) (3) (1) (1)
Fibrous Histiocytoma, Metastatic, Skin 2 (67%) 1 (100%)
Rhabdomyosarcoma 1 (33%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50) (50)
Osteosarcoma, Metastatic, Bone 1 (2%)
____________________________________________________________________________________________________________________________________
Page 11
NTP Experiment-Test: 56111-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:35:47
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD VEHICLE .312% .625% 1.25%
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50) (50)
Alveolar/Bronchiolar Adenoma 2 (4%) 2 (4%) 6 (12%) 6 (12%) 1 (2%)
Alveolar/Bronchiolar Carcinoma 1 (2%) 2 (4%) 1 (2%)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Carcinoma, Metastatic, Preputial Gland 1 (2%)
Carcinoma, Metastatic, Salivary Glands 1 (2%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%)
Fibrosarcoma, Metastatic, Skin 1 (2%) 1 (2%)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%) 1 (2%) 1 (2%)
Osteosarcoma, Metastatic, Uncertain Primary
Site 1 (2%)
Rhabdomyosarcoma, Metastatic, Skeletal Muscle 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Carcinoma, Metastatic, Oral
Mucosa 1 (2%)
Mediastinum, Fibrosarcoma, Metastatic, Skin 1 (2%)
Mediastinum, Osteosarcoma, Metastatic,
Uncertain Primary Site 1 (2%)
Mediastinum, Rhabdomyosarcoma, Metastatic,
Skeletal Muscle 1 (2%)
Nose (50) (50) (50) (50) (50)
Fibroma 1 (2%)
Squamous Cell Carcinoma, Metastatic, Oral
Mucosa 1 (2%)
Trachea (50) (50) (50) (50) (50)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1) (1) (2)
Adenoma 1 (50%)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50) (50)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%) 1 (2%)
Renal Tubule, Adenoma, Multiple 1 (2%)
Urinary Bladder (50) (50) (49) (49) (50)
Page 12
NTP Experiment-Test: 56111-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:35:47
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD VEHICLE .312% .625% 1.25%
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50) *(50)
Leukemia Mononuclear 22 (44%) 18 (36%) 15 (30%) 21 (42%) 9 (18%)
Mesothelioma Malignant 3 (6%) 2 (4%) 5 (10%) 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 13
NTP Experiment-Test: 56111-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:35:47
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD VEHICLE .312% .625% 1.25%
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 50 50 49 48 50
Total Primary Neoplasms 119 121 122 112 95
Total Animals with Benign Neoplasms 50 49 48 48 50
Total Benign Neoplasms 83 90 90 80 76
Total Animals with Malignant Neoplasms 30 27 27 27 19
Total Malignant Neoplasms 36 31 32 32 19
Total Animals with Metastatic Neoplasms 3 3 4 4 3
Total Metastatic Neoplasm 4 9 26 9 7
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 14
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