TDMS Study 56111-03 Pathology Tables
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
FINAL #1
Facility: Battelle Columbus Laboratory
Chemical CAS #: 14371-10-9
Lock Date: 06/01/00
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 5| 2| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 3| 3| 3| 3| 5| 3| 2| 3| 3| 6| 3| 2| 3| 3| 3| 3| 7| 5| 0| 3| 0| 0| 3| 3|
| 7| 6| 5| 7| 7| 2| 6| 3| 5| 6| 0| 5| 4| 7| 7| 6| 5| 6| 7| 3| 7| 2| 8| 5| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
UNTREATD | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X |
Fibrosis | 3 |
Hematopoietic Cell Proliferation | 1 1 |
Hepatodiaphragmatic Nodule | X |
Infarct | 4 |
Inflammation, Chronic Active | 1 3 1 2 2 2 3 1 2 2 2 2 1 1 2 1 1 2 1 3 2 2|
Mixed Cell Focus | X X X X X X X X X X X X X X |
Necrosis | 1 2 2 |
Bile Duct, Hyperplasia | 1 1 1 1 1 2 1 1 1 1 2 1 |
Hepatocyte, Degeneration, Cystic | 2 |
Hepatocyte, Hyperplasia | |
Hepatocyte, Vacuolization Cytoplasmic| 1 1 1 1 1 1 1 3 1 1 1 1 1 1 3 1 1|
|__________________________________________________________________________|
Mesentery | + + + + + + |
Fat, Inflammation, Chronic | |
Fat, Mineralization | 2 2 2 2 |
Fat, Necrosis | 4 4 4 4 4 |
__________________________________________|__________________________________________________________________________|
Page 2
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 5| 2| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 3| 3| 3| 3| 5| 3| 2| 3| 3| 6| 3| 2| 3| 3| 3| 3| 7| 5| 0| 3| 0| 0| 3| 3|
| 7| 6| 5| 7| 7| 2| 6| 3| 5| 6| 0| 5| 4| 7| 7| 6| 5| 6| 7| 3| 7| 2| 8| 5| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
UNTREATD | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + + |
Foreign Body | X X X X X X |
Gingival, Inflammation, Chronic | |
Active | 4 2 1 2 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 1 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 2 2 1 |
Basophilic Focus | X X X X X 2 |
Inflammation, Chronic Active | 1 |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Mineralization | 1 |
Epithelium, Hyperplasia | |
Epithelium, Ulcer | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Epithelium, Erosion | 2 |
Epithelium, Hyperplasia | |
Glands, Ectasia | 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 2 2 2 1 1 1 2 1 1 1 1 2 2|
Mineralization | 1 |
Atrium, Thrombosis | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 3
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 5| 2| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 3| 3| 3| 3| 5| 3| 2| 3| 3| 6| 3| 2| 3| 3| 3| 3| 7| 5| 0| 3| 0| 0| 3| 3|
| 7| 6| 5| 7| 7| 2| 6| 3| 5| 6| 0| 5| 4| 7| 7| 6| 5| 6| 7| 3| 7| 2| 8| 5| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
UNTREATD | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Accessory Adrenal Cortical Nodule | 2 |
Hematopoietic Cell Proliferation | 1 1 |
Hyperplasia | 1 1 2 2 |
Hypertrophy | |
Vacuolization Cytoplasmic | 2 3 1 3 2 1 2 1 2 2 3 3|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M + + M + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 2 |
Pars Distalis, Cyst | 2 2 2 2 2 2 2 3 2 1 1 1 2 1|
Pars Distalis, Hyperplasia | 2 2 2 2 2 2 2 3 3 2 3 2|
Pars Intermedia, Angiectasis | 2 |
Pars Intermedia, Cyst | 2 |
Pars Intermedia, Hyperplasia | 2 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Thymus | 2 |
C-Cell, Hyperplasia | 1 1 2 1 1 1 2 1 1 1 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 4 2 3 2|
Inflammation, Chronic Active | 3 2 1 1 2|
Mineralization | |
Duct, Cyst | 2 2 3 4 3|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3|
__________________________________________|__________________________________________________________________________|
Page 4
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 5| 2| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 3| 3| 3| 3| 5| 3| 2| 3| 3| 6| 3| 2| 3| 3| 3| 3| 7| 5| 0| 3| 0| 0| 3| 3|
| 7| 6| 5| 7| 7| 2| 6| 3| 5| 6| 0| 5| 4| 7| 7| 6| 5| 6| 7| 3| 7| 2| 8| 5| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
UNTREATD | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Cyst | 4 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 3 2 |
Metaplasia, Squamous | |
Cervix, Cyst, Squamous | |
Endometrium, Hyperplasia, Cystic | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 4 3 4 4 4 4 3 3 3 |
Myelofibrosis | 2 |
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + |
Deep Cervical, Ectasia | 2 |
Lumbar, Ectasia | 4 |
Mediastinal, Ectasia | 2 2 2 2 2 2 2 2 2 2 2 |
Mediastinal, Hyperplasia, Lymphoid | 2 2 2 2 4 2 2 2 3 3 2 3 2 |
Mediastinal, Pigmentation | 2 |
|__________________________________________________________________________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M M M M M|
Ectasia | |
Hyperplasia, Lymphoid | |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 2 |
Hyperplasia, Lymphoid | 2 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 4 3 2 |
Hyperplasia, Lymphoid | 3 4 |
Pigmentation | |
|__________________________________________________________________________|
Thymus | + + + + + M + + + + + + M + + M + + + + + M + + +|
Ectopic Parathyroid Gland | 2 |
Inflammation, Chronic Active | 4 |
__________________________________________|__________________________________________________________________________|
Page 5
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 5| 2| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 3| 3| 3| 3| 5| 3| 2| 3| 3| 6| 3| 2| 3| 3| 3| 3| 7| 5| 0| 3| 0| 0| 3| 3|
| 7| 6| 5| 7| 7| 2| 6| 3| 5| 6| 0| 5| 4| 7| 7| 6| 5| 6| 7| 3| 7| 2| 8| 5| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
UNTREATD | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 4 4 |
Hyperplasia, Cystic | 4 2 2 2 2 3 1 4 2 4 2 2 2 3 2 3 3 2 2 3 2 3|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 3 |
Hemorrhage | 3 |
Hydrocephalus | 3 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
Inflammation, Chronic Active | 4 1 1 1 1 1 1 1 1 1 2 1|
Metaplasia, Squamous | 2 |
Mineralization | 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Alveolar Epithelium, Hyperplasia | 4 1 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 2 |
Thrombosis | 2 4 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 2 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 6
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 5| 2| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 3| 3| 3| 3| 5| 3| 2| 3| 3| 6| 3| 2| 3| 3| 3| 3| 7| 5| 0| 3| 0| 0| 3| 3|
| 7| 6| 5| 7| 7| 2| 6| 3| 5| 6| 0| 5| 4| 7| 7| 6| 5| 6| 7| 3| 7| 2| 8| 5| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
UNTREATD | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | |
Lens, Cataract | |
Retina, Degeneration | |
|__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accumulation, Hyaline Droplet | |
Cyst | |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Nephropathy | 2 1 1 1 1 2 1 1 1 1 2 3 2 1 2 1 2 1|
Pigmentation | 4 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 7
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 7| 3| 3| 4| 6| 3| 9| 3| 3| 3| 3| 3| 2| 3| 3| |
| 7| 7| 6| 6| 5| 0| 6| 5| 6| 6| 6| 6| 6| 9| 6| 7| 0| 5| 5| 5| 7| 7| 3| 5| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
UNTREATD | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X | 1 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 1.0|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X | 42 |
Clear Cell Focus | | 1 |
Fibrosis | | 1 3.0|
Hematopoietic Cell Proliferation | 1 | 3 1.0|
Hepatodiaphragmatic Nodule | X X X | 4 |
Infarct | | 1 4.0|
Inflammation, Chronic Active | 2 1 2 2 2 1 2 2 1 1 2 1 2 2 1 2 1 1 2 2 2 2 | 44 1.7|
Mixed Cell Focus | X X X X X X X X X X X X | 26 |
Necrosis | 2 2| 5 1.8|
Bile Duct, Hyperplasia | 2 1 1 1 1 1 2 1 2| 21 1.2|
Hepatocyte, Degeneration, Cystic | | 1 2.0|
Hepatocyte, Hyperplasia | 4 | 1 4.0|
Hepatocyte, Vacuolization Cytoplasmic| 1 1 1 1 1 1 1 4 2 1 1 1 1 3| 31 1.3|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 7| 3| 3| 4| 6| 3| 9| 3| 3| 3| 3| 3| 2| 3| 3| |
| 7| 7| 6| 6| 5| 0| 6| 5| 6| 6| 6| 6| 6| 9| 6| 7| 0| 5| 5| 5| 7| 7| 3| 5| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
UNTREATD | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Mesentery | + + + + +| 11 |
Fat, Inflammation, Chronic | 3 3 3 3| 4 3.0|
Fat, Mineralization | 2 2 2 2| 8 2.0|
Fat, Necrosis | 4 4 4 4 | 9 4.0|
|__________________________________________________________________________|____________|
Oral Mucosa | + + + + +| 12 |
Foreign Body | X X X X X| 11 |
Gingival, Inflammation, Chronic | | |
Active | 2 | 5 2.2|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 1 2 2 1 2 2 1 2 1 1 | 12 1.4|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 1 2 2 2 1 | 11 1.5|
Basophilic Focus | X X X X | 10 2.0|
Inflammation, Chronic Active | | 1 1.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2| 1 2.0|
Mineralization | | 1 1.0|
Epithelium, Hyperplasia | 3| 1 3.0|
Epithelium, Ulcer | 2| 1 2.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 1 | 1 1.0|
Epithelium, Erosion | 2| 2 2.0|
Epithelium, Hyperplasia | 1 | 1 1.0|
Glands, Ectasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 2 1 1| 39 1.1|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 7| 3| 3| 4| 6| 3| 9| 3| 3| 3| 3| 3| 2| 3| 3| |
| 7| 7| 6| 6| 5| 0| 6| 5| 6| 6| 6| 6| 6| 9| 6| 7| 0| 5| 5| 5| 7| 7| 3| 5| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
UNTREATD | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM - cont | | |
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 2 2 2 2 2 1 1 2 2 1 2 2 2 2 2 2 2 2| 36 1.6|
Mineralization | | 1 1.0|
Atrium, Thrombosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | | 1 2.0|
Hematopoietic Cell Proliferation | | 2 1.0|
Hyperplasia | 2 2 2 2 1 2 | 10 1.7|
Hypertrophy | 2 | 1 2.0|
Vacuolization Cytoplasmic | 2 1 1 1 2 1 1 4| 20 1.9|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 3 2.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + + + + + + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | | 2 2.0|
Pars Distalis, Cyst | 2 2 1 1 2 2 2 2 1 2 2 2 2 2 1 2 | 30 1.8|
Pars Distalis, Hyperplasia | 2 2 4 2 2 2 1 2 3 2 2 2| 24 2.2|
Pars Intermedia, Angiectasis | | 1 2.0|
Pars Intermedia, Cyst | 1 | 2 1.5|
Pars Intermedia, Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectopic Thymus | | 1 2.0|
C-Cell, Hyperplasia | 2 1 2 1 1 2 1 2 1 2 1 1 | 23 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 7| 3| 3| 4| 6| 3| 9| 3| 3| 3| 3| 3| 2| 3| 3| |
| 7| 7| 6| 6| 5| 0| 6| 5| 6| 6| 6| 6| 6| 9| 6| 7| 0| 5| 5| 5| 7| 7| 3| 5| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
UNTREATD | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| 49 |
Hyperplasia | 4 2 2 3 2| 11 2.5|
Inflammation, Chronic Active | 2 1 2 1 4 3 1 1 | 13 1.8|
Mineralization | 1| 1 1.0|
Duct, Cyst | 2 2 2 2 3 2 | 11 2.5|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 3.0|
Cyst | 3 4 2 4 2 3 4 4 | 9 3.3|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrometra | | 2 2.5|
Metaplasia, Squamous | 4 | 1 4.0|
Cervix, Cyst, Squamous | 3| 1 3.0|
Endometrium, Hyperplasia, Cystic | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 4 4 4 4 4| 15 3.7|
Myelofibrosis | 3 4 | 3 3.0|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + +| 30 |
Deep Cervical, Ectasia | | 1 2.0|
Lumbar, Ectasia | | 1 4.0|
Mediastinal, Ectasia | 2 2 2 2 | 15 2.0|
Mediastinal, Hyperplasia, Lymphoid | 2 3 3 2 2 2 | 19 2.4|
Mediastinal, Pigmentation | | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M M M M M M M M M + M M M M M M M M M M M M M| 1 |
Ectasia | 2 | 1 2.0|
Hyperplasia, Lymphoid | 2 | 1 2.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 7| 3| 3| 4| 6| 3| 9| 3| 3| 3| 3| 3| 2| 3| 3| |
| 7| 7| 6| 6| 5| 0| 6| 5| 6| 6| 6| 6| 6| 9| 6| 7| 0| 5| 5| 5| 7| 7| 3| 5| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
UNTREATD | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | | 2 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 2 2 3 2 2 2 2 2 | 12 2.5|
Hyperplasia, Lymphoid | | 2 3.5|
Pigmentation | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Thymus | + + + + M + + + + + M + + + + + + + + M + + + + +| 43 |
Ectopic Parathyroid Gland | 1 1 1 | 4 1.3|
Inflammation, Chronic Active | | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 4 4| 5 4.0|
Hyperplasia, Cystic | 2 4 2 2 2 2 2 3 2 2 2 2 1 2 2 3 3 2 3 1 4| 43 2.4|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | | 2 3.0|
Hemorrhage | 2 | 2 2.5|
Hydrocephalus | | 2 2.5|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 7| 3| 3| 4| 6| 3| 9| 3| 3| 3| 3| 3| 2| 3| 3| |
| 7| 7| 6| 6| 5| 0| 6| 5| 6| 6| 6| 6| 6| 9| 6| 7| 0| 5| 5| 5| 7| 7| 3| 5| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
UNTREATD | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | | 1 3.0|
Inflammation, Chronic Active | 1 1 1 2 1 2 1 1 1 1 1 2 2 1 1 1 1 1 1 | 31 1.3|
Metaplasia, Squamous | | 1 2.0|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 45 1.0|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 44 1.0|
Alveolar Epithelium, Hyperplasia | 2 2 2 2 1 2 1 1 1 | 12 1.8|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 | 44 1.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 2 | 4 2.3|
Thrombosis | | 2 3.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 2 | 4 2.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + | 1 |
Lens, Cataract | 4 | 1 4.0|
Retina, Degeneration | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accumulation, Hyaline Droplet | 3 | 1 3.0|
Cyst | 2 | 1 2.0|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 30 1.0|
Nephropathy | 1 1 2 1 2 1 1 1 1 3 1 1 1 1 2 1 2 1 1 1 1 | 39 1.4|
Pigmentation | | 1 4.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 7| 3| 3| 4| 6| 3| 9| 3| 3| 3| 3| 3| 2| 3| 3| |
| 7| 7| 6| 6| 5| 0| 6| 5| 6| 6| 6| 6| 6| 9| 6| 7| 0| 5| 5| 5| 7| 7| 3| 5| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
UNTREATD | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 5| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 2| 3| 3| 9| 3| 9| 3| 7| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 7| 3| 3| 3|
| 7| 5| 6| 6| 5| 7| 7| 0| 6| 0| 7| 5| 2| 5| 6| 6| 7| 2| 5| 6| 7| 9| 5| 5| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X X |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | |
Eosinophilic Focus | X |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X X |
Inflammation, Chronic Active | 2 2 2 1 1 1 2 1 2 2 2 2 1 2 1 2 2 2 2 2|
Mixed Cell Focus | X X X X X X X X X X X X|
Necrosis | 2 |
Pigmentation | 2 |
Bile Duct, Hyperplasia | 2 1 1 2 1 1 1 1 1 2 1 2 1|
Hepatocyte, Degeneration, Cystic | |
Hepatocyte, Hyperplasia | |
Hepatocyte, Vacuolization Cytoplasmic| 1 1 1 2 1 1 1 1 1 2 1 4 1 |
|__________________________________________________________________________|
Mesentery | + + + + |
Fat, Inflammation, Chronic | 3 2 3 2 |
Fat, Mineralization | 1 2 1 |
Fat, Necrosis | 4 4 4 4 |
|__________________________________________________________________________|
Oral Mucosa | + + + |
__________________________________________|__________________________________________________________________________|
Page 15
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 5| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 2| 3| 3| 9| 3| 9| 3| 7| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 7| 3| 3| 3|
| 7| 5| 6| 6| 5| 7| 7| 0| 6| 0| 7| 5| 2| 5| 6| 6| 7| 2| 5| 6| 7| 9| 5| 5| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Foreign Body | X X X |
Gingival, Hyperplasia, Squamous | |
Gingival, Inflammation, Chronic | |
Active | 2 2 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 2 2 2 1 1|
Acinus, Hyperplasia | |
Duct, Cyst | 2 2 2 2 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 2 1 1 1 1 2 2|
Basophilic Focus | X X X X |
Inflammation, Chronic Active | 1 |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Ectasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 2 2 1 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 1 |
Angiectasis | |
Hematopoietic Cell Proliferation | |
Hyperplasia | 2 2 2 1 2 2 2 2 1 2 2 |
Hypertrophy | 2 2 |
Necrosis | 1 |
Vacuolization Cytoplasmic | 1 2 1 1 2 3 2 1|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 16
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 5| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 2| 3| 3| 9| 3| 9| 3| 7| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 7| 3| 3| 3|
| 7| 5| 6| 6| 5| 7| 7| 0| 6| 0| 7| 5| 2| 5| 6| 6| 7| 2| 5| 6| 7| 9| 5| 5| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 2 1 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | 2 1 2 2 2 1 2 1 2 1 2 3 |
Pars Distalis, Hyperplasia | 1 2 2 2 2 2 2 2 2 2 2 |
Pars Intermedia, Hyperplasia | 2 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 2 1 1 2 1 2 1 2 1 1 1 1 1 1 1 |
Follicle, Cyst | 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 2 2 |
Inflammation, Chronic Active | 1 2 1|
Duct, Cyst | 2 2 3 2 2 2 2 3 2 |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Granulosa Cell, Hyperplasia | 2 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 2 |
Cervix, Epithelium, Hyperplasia | |
Endometrium, Hyperplasia, Cystic | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 17
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 5| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 2| 3| 3| 9| 3| 9| 3| 7| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 7| 3| 3| 3|
| 7| 5| 6| 6| 5| 7| 7| 0| 6| 0| 7| 5| 2| 5| 6| 6| 7| 2| 5| 6| 7| 9| 5| 5| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 4 4 4 4 4 4 |
Myelofibrosis | |
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + |
Mediastinal, Ectasia | 2 2 2 2 2 2 2 2 2 |
Mediastinal, Hyperplasia, Lymphoid | 2 2 2 3 4 2 2 2 3 2 2 |
|__________________________________________________________________________|
Lymph Node, Mandibular | M M M M M M M M M M M + M M M M M M M M M M M M M|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hematopoietic Cell Proliferation | 3 2 |
Hyperplasia, Lymphoid | |
Infarct | |
Pigmentation | |
|__________________________________________________________________________|
Thymus | + + M + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Parathyroid Gland | 2 2 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 |
Cyst, Multiple | 4 |
Hyperplasia, Cystic | 2 2 2 2 3 2 2 2 2 2 2 3 2 2 3 2 2 3 2 3 2 2 2|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Inflammation, Chronic Active | |
Epidermis, Hyperplasia | |
Epidermis, Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 18
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 5| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 2| 3| 3| 9| 3| 9| 3| 7| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 7| 3| 3| 3|
| 7| 5| 6| 6| 5| 7| 7| 0| 6| 0| 7| 5| 2| 5| 6| 6| 7| 2| 5| 6| 7| 9| 5| 5| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 |
Hydrocephalus | 2 3 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Alveolar Epithelium, Hyperplasia | 1 1 1 1 4|
Alveolar Epithelium, Metaplasia, | |
Focal, Squamous | 3 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 |
Thrombosis | 1 4 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 3 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
__________________________________________|__________________________________________________________________________|
Page 19
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 5| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 2| 3| 3| 9| 3| 9| 3| 7| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 7| 3| 3| 3|
| 7| 5| 6| 6| 5| 7| 7| 0| 6| 0| 7| 5| 2| 5| 6| 6| 7| 2| 5| 6| 7| 9| 5| 5| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
Cyst | 3 |
Hydronephrosis | |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Nephropathy | 1 1 1 1 1 2 1 1 2 1 1 1 1 2 2 1 1 2 1 2|
Pigmentation | 3 |
Pelvis, Inflammation, Suppurative | 2 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 20
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 3| 3| 3| 9| 3| 3| 3| 2| 3| 2| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 0| 3| 9| 3| 3| |
| 6| 6| 5| 5| 6| 6| 7| 0| 7| 3| 6| 7| 5| 6| 3| 4| 6| 6| 6| 7| 2| 7| 0| 5| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
VEHICLE | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X | 5 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X X | 4 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X| 44 |
Clear Cell Focus | X X | 2 |
Eosinophilic Focus | | 1 |
Hematopoietic Cell Proliferation | 1 1 | 2 1.0|
Hepatodiaphragmatic Nodule | X X X | 5 |
Inflammation, Chronic Active | 2 2 2 1 2 2 2 1 2 2 2 2 2 2 1 2 2 1 1 1 1| 41 1.7|
Mixed Cell Focus | X X X X X X X X X X X X X | 25 |
Necrosis | 2 3 | 3 2.3|
Pigmentation | | 1 2.0|
Bile Duct, Hyperplasia | 1 1 1 2 1 1 1 1 2 1 1 1 | 25 1.2|
Hepatocyte, Degeneration, Cystic | 2 | 1 2.0|
Hepatocyte, Hyperplasia | 4 | 1 4.0|
Hepatocyte, Vacuolization Cytoplasmic| 1 1 1 1 2 2 3 1 1 1 2 1 3 1 1 1 2 1 1| 32 1.4|
|__________________________________________________________________________|____________|
Mesentery | + + + + + | 9 |
Fat, Inflammation, Chronic | 4 3 3 2 | 8 2.8|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 3| 3| 3| 9| 3| 3| 3| 2| 3| 2| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 0| 3| 9| 3| 3| |
| 6| 6| 5| 5| 6| 6| 7| 0| 7| 3| 6| 7| 5| 6| 3| 4| 6| 6| 6| 7| 2| 7| 0| 5| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
VEHICLE | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Fat, Mineralization | 1 1 | 5 1.2|
Fat, Necrosis | 4 4 4 | 7 4.0|
|__________________________________________________________________________|____________|
Oral Mucosa | + + + + + + + + | 11 |
Foreign Body | X X X X X X | 9 |
Gingival, Hyperplasia, Squamous | 2 | 1 2.0|
Gingival, Inflammation, Chronic | | |
Active | 2 2 3 2 2 2 | 8 2.1|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 2 1 1 2 2 1 2 4| 14 1.7|
Acinus, Hyperplasia | 3 | 1 3.0|
Duct, Cyst | 2 2 2 2 | 8 2.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 1 2 1 1 1 1 1 1 2| 19 1.3|
Basophilic Focus | X X X | 7 |
Inflammation, Chronic Active | | 1 1.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Glands, Ectasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1| 36 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 2 2 2 2 1 2 2 2 1 2 1 2 2 2 2 2 1 2 2 2| 45 1.8|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 3| 3| 3| 9| 3| 3| 3| 2| 3| 2| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 0| 3| 9| 3| 3| |
| 6| 6| 5| 5| 6| 6| 7| 0| 7| 3| 6| 7| 5| 6| 3| 4| 6| 6| 6| 7| 2| 7| 0| 5| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
VEHICLE | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Accessory Adrenal Cortical Nodule | | 2 1.5|
Angiectasis | 3 | 1 3.0|
Hematopoietic Cell Proliferation | 1 | 1 1.0|
Hyperplasia | 1 1 2 2 1 2 | 17 1.7|
Hypertrophy | 1 2 | 4 1.8|
Necrosis | | 1 1.0|
Vacuolization Cytoplasmic | 1 2 1 2 2 2 1 1 2 2 | 18 1.6|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 | 6 1.7|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + M M + + M M M + M + + + + +| 43 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | 2 2 | 2 2.0|
Pars Distalis, Cyst | 2 2 1 2 3 3 1 2 2 2 1 2 2 2 2| 27 1.9|
Pars Distalis, Hyperplasia | 2 2 3 2 2 2 2 2 | 19 2.0|
Pars Intermedia, Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 1 1 2 2 1 1 1 1 1 1 1 2 2 1 | 33 1.2|
Follicle, Cyst | 2 | 2 2.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 3 2 3 | 11 2.2|
Inflammation, Chronic Active | 1 1 2 2 1 2 | 9 1.4|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 3| 3| 3| 9| 3| 3| 3| 2| 3| 2| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 0| 3| 9| 3| 3| |
| 6| 6| 5| 5| 6| 6| 7| 0| 7| 3| 6| 7| 5| 6| 3| 4| 6| 6| 6| 7| 2| 7| 0| 5| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
VEHICLE | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Duct, Cyst | 2 2 2 2 3 3 3 | 16 2.3|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 4 2 3 4 2 | 5 3.0|
Granulosa Cell, Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrometra | 2 | 2 2.0|
Cervix, Epithelium, Hyperplasia | 3 | 1 3.0|
Endometrium, Hyperplasia, Cystic | 2 1 1 2 | 5 1.6|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 4 3 4 4 4 3 4 4 | 16 3.8|
Myelofibrosis | 2 2 | 2 2.0|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + | 25 |
Mediastinal, Ectasia | 2 2 2 2 2 2 2 2 | 17 2.0|
Mediastinal, Hyperplasia, Lymphoid | 2 2 2 2 2 2 2 3 3 | 20 2.3|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M M M M +| 2 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 2 2 3 | 5 2.4|
Hyperplasia, Lymphoid | 4 | 1 4.0|
Infarct | 4 | 1 4.0|
Pigmentation | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 3| 3| 3| 9| 3| 3| 3| 2| 3| 2| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 0| 3| 9| 3| 3| |
| 6| 6| 5| 5| 6| 6| 7| 0| 7| 3| 6| 7| 5| 6| 3| 4| 6| 6| 6| 7| 2| 7| 0| 5| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
VEHICLE | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Ectopic Parathyroid Gland | 2 | 4 1.8|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 4 4 | 3 4.0|
Cyst, Multiple | | 1 4.0|
Hyperplasia, Cystic | 2 2 2 2 2 2 3 2 3 3 3 1 2 4 2 2 4 2 4 2 3 3 4 2| 47 2.4|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 4 | 1 4.0|
Inflammation, Chronic Active | 4 | 1 4.0|
Epidermis, Hyperplasia | 3 | 1 3.0|
Epidermis, Ulcer | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 2 2 | 3 2.3|
Hydrocephalus | 2 2 | 5 2.2|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 2 1 1 1 1 1 1 1 2 1 2 1 1 1 1 1 1 2| 36 1.1|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 45 1.0|
Pigmentation | 2 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 47 1.0|
Alveolar Epithelium, Hyperplasia | 2 2 1 2 1 1 2 | 12 1.6|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 3| 3| 3| 9| 3| 3| 3| 2| 3| 2| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 0| 3| 9| 3| 3| |
| 6| 6| 5| 5| 6| 6| 7| 0| 7| 3| 6| 7| 5| 6| 3| 4| 6| 6| 6| 7| 2| 7| 0| 5| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
VEHICLE | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Alveolar Epithelium, Metaplasia, | | |
Focal, Squamous | | 1 3.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 47 1.1|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 1.0|
Thrombosis | 2 | 3 2.3|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 3 2 2| 5 2.4|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 | 1 3.0|
Cyst | | 1 3.0|
Hydronephrosis | 2 | 1 2.0|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 38 1.0|
Nephropathy | 1 1 1 1 1 1 2 1 1 1 2 2 2 1 1 2 2 2 1 1 1 2 1 | 43 1.3|
Pigmentation | | 1 3.0|
Pelvis, Inflammation, Suppurative | | 1 2.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 5| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 2| 3| 3| 3| 7| 3| 3| 3| 3| 3| 7| 6| 9| 3| 0| 3| 2| 3| 7| 3| 3| 3|
| 5| 6| 5| 0| 5| 5| 6| 1| 6| 6| 7| 7| 7| 5| 1| 7| 7| 1| 7| 6| 5| 5| 5| 5| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
.312% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X |
Hematopoietic Cell Proliferation | 1 |
Hepatodiaphragmatic Nodule | X X X X |
Inflammation, Chronic Active | 2 1 3 2 2 2 2 2 2 2 2 1 1 2 2 2 2 2 1 2 2 2|
Mixed Cell Focus | X X X X X X X X X X X X X|
Necrosis | 3 3 |
Pigmentation | |
Thrombosis | 2 |
Bile Duct, Hyperplasia | 1 1 1 1 3 1 1 1 1 1 1 1 1 |
Hepatocyte, Hyperplasia | 3 2 |
Hepatocyte, Vacuolization Cytoplasmic| 1 3 1 2 1 1 1 1 1 2 1 3 1 1 1 |
|__________________________________________________________________________|
Mesentery | + + + |
Inflammation, Chronic | 4 |
Fat, Inflammation, Chronic | 3 |
Fat, Mineralization | 2 |
Fat, Necrosis | 4 4 |
__________________________________________|__________________________________________________________________________|
Page 27
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 5| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 2| 3| 3| 3| 7| 3| 3| 3| 3| 3| 7| 6| 9| 3| 0| 3| 2| 3| 7| 3| 3| 3|
| 5| 6| 5| 0| 5| 5| 6| 1| 6| 6| 7| 7| 7| 5| 1| 7| 7| 1| 7| 6| 5| 5| 5| 5| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
.312% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + + + + + + + + + |
Foreign Body | X X X X X X X X X X X X X X |
Gingival, Inflammation, Chronic | |
Active | 2 2 4 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 1 1 1 1 2|
Acinus, Hyperplasia | |
Duct, Cyst | 2 2 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + M + + + + + + + + + +|
Atrophy | 1 2 1 2 |
Basophilic Focus | X X X X X |
Inflammation, Chronic Active | |
Mineralization | |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperkeratosis | 2 2 |
Epithelium, Hyperplasia | 2 2 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Ectasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
|__________________________________________________________________________|
Tongue | M |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 1 2 2 2 3 1 2 1 2 2 3 2 2 2 1 2 2 2 2 2|
Mineralization | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 |
__________________________________________|__________________________________________________________________________|
Page 28
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 5| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 2| 3| 3| 3| 7| 3| 3| 3| 3| 3| 7| 6| 9| 3| 0| 3| 2| 3| 7| 3| 3| 3|
| 5| 6| 5| 0| 5| 5| 6| 1| 6| 6| 7| 7| 7| 5| 1| 7| 7| 1| 7| 6| 5| 5| 5| 5| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
.312% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Hematopoietic Cell Proliferation | 1 1 |
Hyperplasia | 1 1 2 2 2 1|
Hypertrophy | |
Necrosis | 3 |
Vacuolization Cytoplasmic | 2 3 1 1 1 1 1 1 1 1 1 1|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + M + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 1 |
Pars Distalis, Cyst | 2 4 3 3 2 1 2 3 2 3 2 1 3 1 2 1|
Pars Distalis, Hyperplasia | 3 2 2 1 3 4 1 2 |
Pars Distalis, Mineralization | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + M + + + + + + + + + +|
Inflammation, Chronic | |
Ultimobranchial Cyst | 1 |
C-Cell, Hyperplasia | 2 2 1 1 2 1 2 2 1 1 |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 4 4 2 2 2 4 2 1 |
Inflammation, Chronic Active | 1 3 1 1 1 2 3 1 1 1 |
Duct, Cyst | 2 3 2|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Cyst | 2 4 2 |
__________________________________________|__________________________________________________________________________|
Page 29
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 5| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 2| 3| 3| 3| 7| 3| 3| 3| 3| 3| 7| 6| 9| 3| 0| 3| 2| 3| 7| 3| 3| 3|
| 5| 6| 5| 0| 5| 5| 6| 1| 6| 6| 7| 7| 7| 5| 1| 7| 7| 1| 7| 6| 5| 5| 5| 5| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
.312% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Mineralization | 1 |
Interstitial Cell, Hyperplasia | 2 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hydrometra | 4 2 |
Inflammation, Chronic Active | |
Endometrium, Hyperplasia, Cystic | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 3 4 4 3 3 3 |
Myelofibrosis | |
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + |
Deep Cervical, Ectasia | 2 |
Deep Cervical, Hyperplasia, Lymphoid | 2 |
Deep Cervical, Inflammation, Chronic | |
Mediastinal, Ectasia | 2 2 2 2 1 2 2 2 2 2 |
Mediastinal, Hyperplasia, Lymphoid | 2 3 3 3 2 3 2 3 3 2 2 |
Mediastinal, Inflammation, Chronic | |
Mediastinal, Pigmentation | 2 2 |
|__________________________________________________________________________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 3 2 |
|__________________________________________________________________________|
Thymus | + + + + + + + M + + + + + + + + + + + + + + + + +|
Ectopic Parathyroid Gland | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________|__________________________________________________________________________|
Page 30
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 5| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 2| 3| 3| 3| 7| 3| 3| 3| 3| 3| 7| 6| 9| 3| 0| 3| 2| 3| 7| 3| 3| 3|
| 5| 6| 5| 0| 5| 5| 6| 1| 6| 6| 7| 7| 7| 5| 1| 7| 7| 1| 7| 6| 5| 5| 5| 5| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
.312% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
Hyperplasia, Cystic | 2 2 2 2 4 2 2 2 2 2 3 2 2 3 2 3 2 3 3 2 2 2|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | |
|__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 3 |
Hydrocephalus | 2 2 2 2 2 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Inflammation, Chronic Active | 1 1 1 1 2 1 1 2 1 1 1 1 1 2 1 1 1 1 1 1 1 1|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Alveolar Epithelium, Hyperplasia | 1 2 3 3 2 1 1 1 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Inflammation, | |
Suppurative | 1 2 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + |
__________________________________________|__________________________________________________________________________|
Page 31
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 5| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 2| 3| 3| 3| 7| 3| 3| 3| 3| 3| 7| 6| 9| 3| 0| 3| 2| 3| 7| 3| 3| 3|
| 5| 6| 5| 0| 5| 5| 6| 1| 6| 6| 7| 7| 7| 5| 1| 7| 7| 1| 7| 6| 5| 5| 5| 5| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
.312% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
Lens, Cataract | 4 4 |
Retina, Degeneration | 4 4 |
|__________________________________________________________________________|
Zymbal's Gland | + + |
Cyst | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 |
Nephropathy | 1 1 2 1 2 2 1 1 2 2 1 1 1 1 1 2 1 1 2 2|
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 32
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 5| 7| 6| 7| 6| 7| 7| |
DAY ON TEST | 1| 3| 3| 3| 3| 1| 8| 3| 3| 3| 3| 3| 8| 3| 3| 1| 5| 3| 9| 3| 5| 3| 9| 3| 3| |
| 8| 5| 5| 6| 7| 8| 5| 5| 6| 6| 5| 5| 1| 5| 5| 8| 2| 7| 7| 7| 2| 6| 7| 7| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
.312% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | | 1 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X | 1 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 4.0|
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X| 42 |
Clear Cell Focus | | 2 |
Hematopoietic Cell Proliferation | 2 2 | 3 1.7|
Hepatodiaphragmatic Nodule | X X X X X X X X | 12 |
Inflammation, Chronic Active | 3 2 1 3 2 2 2 1 2 2 2 1 1 1 1 2 2 1 2 2| 42 1.8|
Mixed Cell Focus | X X X X X X X X X X X| 24 |
Necrosis | 2 1 | 4 2.3|
Pigmentation | 1 | 1 1.0|
Thrombosis | | 1 2.0|
Bile Duct, Hyperplasia | 2 1 2 2 1 1 1 1 1 1 1 2 1 1 1 | 28 1.2|
Hepatocyte, Hyperplasia | | 2 2.5|
Hepatocyte, Vacuolization Cytoplasmic| 1 4 1 1 1 1 3 3 1 1 | 25 1.5|
|__________________________________________________________________________|____________|
Mesentery | + + + | 6 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 5| 7| 6| 7| 6| 7| 7| |
DAY ON TEST | 1| 3| 3| 3| 3| 1| 8| 3| 3| 3| 3| 3| 8| 3| 3| 1| 5| 3| 9| 3| 5| 3| 9| 3| 3| |
| 8| 5| 5| 6| 7| 8| 5| 5| 6| 6| 5| 5| 1| 5| 5| 8| 2| 7| 7| 7| 2| 6| 7| 7| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
.312% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Inflammation, Chronic | | 1 4.0|
Fat, Inflammation, Chronic | 3 2 3 | 4 2.8|
Fat, Mineralization | 2 | 2 2.0|
Fat, Necrosis | 4 4 4 | 5 4.0|
|__________________________________________________________________________|____________|
Oral Mucosa | + + + + + + + + + + | 24 |
Foreign Body | X X X X X X X X X X | 24 |
Gingival, Inflammation, Chronic | | |
Active | 1 2 2 2 2 | 8 2.1|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 1 1 1 1 2 2 1 2 | 14 1.3|
Acinus, Hyperplasia | 1 | 1 1.0|
Duct, Cyst | 2 2 | 4 2.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 1 1 2 1 | 8 1.4|
Basophilic Focus | X | 6 |
Inflammation, Chronic Active | 2 1 | 2 1.5|
Mineralization | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Hyperkeratosis | | 2 2.0|
Epithelium, Hyperplasia | | 2 2.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Glands, Ectasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 36 1.0|
|__________________________________________________________________________|____________|
Tongue | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 5| 7| 6| 7| 6| 7| 7| |
DAY ON TEST | 1| 3| 3| 3| 3| 1| 8| 3| 3| 3| 3| 3| 8| 3| 3| 1| 5| 3| 9| 3| 5| 3| 9| 3| 3| |
| 8| 5| 5| 6| 7| 8| 5| 5| 6| 6| 5| 5| 1| 5| 5| 8| 2| 7| 7| 7| 2| 6| 7| 7| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
.312% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM - cont | | |
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 1 2 2 2 2 2 2 2 1 2 2 1 2 2 2 2 1 2 2 2 2| 45 1.9|
Mineralization | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | | 1 2.0|
Hematopoietic Cell Proliferation | 1 1 1 | 5 1.0|
Hyperplasia | 2 2 2| 9 1.7|
Hypertrophy | 1 1 | 2 1.0|
Necrosis | 2 | 2 2.5|
Vacuolization Cytoplasmic | 1 1 1 1 1 2 1 2 2 1 1 2 1| 25 1.3|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 1 2 | 3 1.3|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + M + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | 3 | 3 2.0|
Pars Distalis, Cyst | 2 2 1 1 1 2 2 2 2 2 2 | 27 2.0|
Pars Distalis, Hyperplasia | 2 2 2 2 2 3 2 2 4 2 3 2 2| 21 2.3|
Pars Distalis, Mineralization | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | 4 | 1 4.0|
Ultimobranchial Cyst | | 1 1.0|
C-Cell, Hyperplasia | 1 2 1 1 1 2 1 2 1 2 1 1 1| 23 1.4|
Follicular Cell, Hyperplasia | 1 | 2 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 5| 7| 6| 7| 6| 7| 7| |
DAY ON TEST | 1| 3| 3| 3| 3| 1| 8| 3| 3| 3| 3| 3| 8| 3| 3| 1| 5| 3| 9| 3| 5| 3| 9| 3| 3| |
| 8| 5| 5| 6| 7| 8| 5| 5| 6| 6| 5| 5| 1| 5| 5| 8| 2| 7| 7| 7| 2| 6| 7| 7| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
.312% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 3 2 1 3 2 2| 17 2.4|
Inflammation, Chronic Active | 4 1 1 1 1 1 1 2 2 1 2| 21 1.5|
Duct, Cyst | 2 3 2 3 | 7 2.4|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 3.0|
Cyst | 2 4 | 5 2.8|
Mineralization | | 1 1.0|
Interstitial Cell, Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 4| 1 4.0|
Hydrometra | 3 3 2 | 5 2.8|
Inflammation, Chronic Active | 2 | 1 2.0|
Endometrium, Hyperplasia, Cystic | 1 2 | 2 1.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 4 4 4 4 4 | 13 3.6|
Myelofibrosis | 3 4 | 2 3.5|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + +| 26 |
Deep Cervical, Ectasia | | 1 2.0|
Deep Cervical, Hyperplasia, Lymphoid | | 1 2.0|
Deep Cervical, Inflammation, Chronic | 4 | 1 4.0|
Mediastinal, Ectasia | 2 2 2 2 2 2 3 2 2 2 2| 21 2.0|
Mediastinal, Hyperplasia, Lymphoid | 2 3 3 2 2 2 2 2 2 2| 21 2.4|
Mediastinal, Inflammation, Chronic | 4 | 1 4.0|
Mediastinal, Pigmentation | 2 2 | 4 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M M M M M| |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 5| 7| 6| 7| 6| 7| 7| |
DAY ON TEST | 1| 3| 3| 3| 3| 1| 8| 3| 3| 3| 3| 3| 8| 3| 3| 1| 5| 3| 9| 3| 5| 3| 9| 3| 3| |
| 8| 5| 5| 6| 7| 8| 5| 5| 6| 6| 5| 5| 1| 5| 5| 8| 2| 7| 7| 7| 2| 6| 7| 7| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
.312% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 2 3 3 3 | 8 2.8|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + M + + + M| 47 |
Ectopic Parathyroid Gland | 2 2 1 | 3 1.7|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 4 3 4 | 3 3.7|
Hyperplasia, Cystic | 1 1 2 2 2 3 2 2 2 3 4 2 3 2 2 2 2 2 3 2 3 2 2| 45 2.3|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Osteopetrosis | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 3 | 3 2.7|
Hydrocephalus | 3 1 2 2 | 10 2.1|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 4 | 1 4.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 5| 7| 6| 7| 6| 7| 7| |
DAY ON TEST | 1| 3| 3| 3| 3| 1| 8| 3| 3| 3| 3| 3| 8| 3| 3| 1| 5| 3| 9| 3| 5| 3| 9| 3| 3| |
| 8| 5| 5| 6| 7| 8| 5| 5| 6| 6| 5| 5| 1| 5| 5| 8| 2| 7| 7| 7| 2| 6| 7| 7| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
.312% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Inflammation, Chronic Active | 2 2 1 1 1 1 1 1 1 1 1 2 1 1 2 1 2 1| 40 1.2|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 47 1.0|
Pigmentation | 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 44 1.0|
Alveolar Epithelium, Hyperplasia | 1 1 2 2 3 2| 15 1.7|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 44 1.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 | 3 1.7|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + | 3 |
Lens, Cataract | 2 | 3 3.3|
Retina, Degeneration | 3 | 3 3.7|
|__________________________________________________________________________|____________|
Zymbal's Gland | | 2 |
Cyst | | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct | 2 | 1 2.0|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 28 1.0|
Nephropathy | 2 2 2 1 1 1 1 2 1 1 1 1 2 1 2 2 1 1 2 1 1| 41 1.4|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 4| 7| 1| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 0| 3| 7| 3| 7| 3| 3| 3| 3| 3| 4| 3| 3| 5| 3| 3| 1| 3| 3| 3| 3|
| 7| 5| 5| 7| 2| 7| 0| 7| 7| 5| 5| 7| 5| 5| 3| 7| 5| 2| 6| 6| 0| 7| 6| 6| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
.625% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X|
Hepatodiaphragmatic Nodule | X X X X X |
Inflammation, Chronic Active | 2 2 3 1 2 1 3 1 1 2 3 1 2 3 2 2 2 2 2 2 2 2|
Mixed Cell Focus | X X X X X X X X X X X X X X X|
Necrosis | 3 |
Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Hepatocyte, Vacuolization Cytoplasmic| 1 1 1 2 1 1 |
|__________________________________________________________________________|
Mesentery | + + + |
Fat, Inflammation, Chronic | 2 2 2 |
Fat, Mineralization | 2 2 |
Fat, Necrosis | 4 4 4 |
|__________________________________________________________________________|
Oral Mucosa | + + + + + +|
Foreign Body | X X X X X X|
Gingival, Inflammation, Chronic | |
Active | 1|
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
__________________________________________|__________________________________________________________________________|
Page 39
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 4| 7| 1| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 0| 3| 7| 3| 7| 3| 3| 3| 3| 3| 4| 3| 3| 5| 3| 3| 1| 3| 3| 3| 3|
| 7| 5| 5| 7| 2| 7| 0| 7| 7| 5| 5| 7| 5| 5| 3| 7| 5| 2| 6| 6| 0| 7| 6| 6| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
.625% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Inflammation, Chronic Active | 1 2 |
Acinus, Atrophy | 2 1 |
Duct, Cyst | 2 2 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 1 1 2 2 |
Basophilic Focus | X X X X|
Vacuolization Cytoplasmic | |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 |
Epithelium, Hyperkeratosis | |
Epithelium, Hyperplasia | 2 |
Epithelium, Ulcer | 4 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Epithelium, Ulcer | |
Glands, Ectasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
|__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 1 2 1 2 2 2 2 2 2 2 2 1 2 2 2 2|
Mineralization | |
Valve, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 1 |
Hyperplasia | 2 1 2 2 |
Hypertrophy | 2 2 |
Necrosis | |
__________________________________________|__________________________________________________________________________|
Page 40
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 4| 7| 1| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 0| 3| 7| 3| 7| 3| 3| 3| 3| 3| 4| 3| 3| 5| 3| 3| 1| 3| 3| 3| 3|
| 7| 5| 5| 7| 2| 7| 0| 7| 7| 5| 5| 7| 5| 5| 3| 7| 5| 2| 6| 6| 0| 7| 6| 6| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
.625% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Vacuolization Cytoplasmic | 1 2 1 1 1 2 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + + M M + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | 2 1 2 3 2 3 2 2 3 |
Pars Distalis, Hyperplasia | 2 1 2 2 2 2 2 1 3 2 2 2 2 1|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | 1 |
C-Cell, Hyperplasia | 1 2 1 1 1 1 2 2 1 1 1 2|
Follicle, Cyst | 2 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 2 2 2 |
Inflammation, Chronic Active | 2 1 1 2 2 4 1 1 2 1 |
Duct, Cyst | 2 2 3 4 2 |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Mineralization | 1 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 3 2 |
Inflammation, Chronic Active | |
Endometrium, Hyperplasia, Cystic | 2 2 |
__________________________________________|__________________________________________________________________________|
Page 41
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 4| 7| 1| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 0| 3| 7| 3| 7| 3| 3| 3| 3| 3| 4| 3| 3| 5| 3| 3| 1| 3| 3| 3| 3|
| 7| 5| 5| 7| 2| 7| 0| 7| 7| 5| 5| 7| 5| 5| 3| 7| 5| 2| 6| 6| 0| 7| 6| 6| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
.625% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 4 4 2 |
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + +|
Deep Cervical, Ectasia | |
Deep Cervical, Hyperplasia, Lymphoid | |
Deep Cervical, Pigmentation | |
Mediastinal, Ectasia | 2 2 2 2 2 2 2 2 2 2 2 2|
Mediastinal, Hyperplasia, Lymphoid | 2 2 2 2 3 2 3 2 2 2 2 2|
Mediastinal, Pigmentation | |
|__________________________________________________________________________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M + M M M M M M M|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Parathyroid Gland | 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 4 |
Hyperplasia, Cystic | 2 2 2 2 2 2 2 2 2 2 2 4 2 2 2 1 2 2|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 |
__________________________________________|__________________________________________________________________________|
Page 42
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 4| 7| 1| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 0| 3| 7| 3| 7| 3| 3| 3| 3| 3| 4| 3| 3| 5| 3| 3| 1| 3| 3| 3| 3|
| 7| 5| 5| 7| 2| 7| 0| 7| 7| 5| 5| 7| 5| 5| 3| 7| 5| 2| 6| 6| 0| 7| 6| 6| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
.625% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM - cont | |
Hemorrhage | 2 1 |
Hydrocephalus | 2 2 |
Inflammation, Chronic Active | 2 |
|__________________________________________________________________________|
Peripheral Nerve | |
|__________________________________________________________________________|
Spinal Cord | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 1 1 2 1 1 1 1 2 1 1 1 1 1 1 1 1 1|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Alveolar Epithelium, Hyperplasia | 2 1 2 1 2 1 2 2 1 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 2 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + |
Retina, Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Nephropathy | 1 1 1 2 1 1 1 2 1 2 1 1 1 2 1 1 1 1 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 43
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 4| 7| 1| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 0| 3| 7| 3| 7| 3| 3| 3| 3| 3| 4| 3| 3| 5| 3| 3| 1| 3| 3| 3| 3|
| 7| 5| 5| 7| 2| 7| 0| 7| 7| 5| 5| 7| 5| 5| 3| 7| 5| 2| 6| 6| 0| 7| 6| 6| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
.625% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
Transitional Epithelium, Hyperplasia | 3 |
Transitional Epithelium, Metaplasia, | |
Squamous | 2 |
__________________________________________|__________________________________________________________________________
Page 44
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
__________________________________________________________________________________________________________________________________
| 0| 7| 7| 4| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 6| 7| |
DAY ON TEST | 5| 3| 3| 5| 3| 3| 1| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 3| 8| 3| |
| 0| 5| 6| 9| 4| 6| 3| 6| 7| 6| 2| 6| 5| 5| 5| 6| 7| 7| 9| 8| 6| 2| 7| 1| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
.625% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | X X X | 4 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | X | 3 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X| 43 |
Hepatodiaphragmatic Nodule | X X X X| 9 |
Inflammation, Chronic Active | 2 2 2 2 2 1 1 1 2 1 1 2 1 2 1 2 2 1 1 2| 42 1.8|
Mixed Cell Focus | X X X X X X X X X X X X | 27 |
Necrosis | | 1 3.0|
Bile Duct, Hyperplasia | 1 1 1 1 1 1 1| 21 1.0|
Hepatocyte, Vacuolization Cytoplasmic| 4 3 1 1 1 1 1 1 | 14 1.4|
|__________________________________________________________________________|____________|
Mesentery | + + + + + + | 9 |
Fat, Inflammation, Chronic | 3 2 3 2 2 | 8 2.3|
Fat, Mineralization | 1 2 1 | 5 1.6|
Fat, Necrosis | 4 4 4 4 4 4 | 9 4.0|
|__________________________________________________________________________|____________|
Oral Mucosa | + + + + + + + + + + + +| 18 |
Foreign Body | X X X X X X X X X X X| 17 |
Gingival, Inflammation, Chronic | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
__________________________________________________________________________________________________________________________________
| 0| 7| 7| 4| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 6| 7| |
DAY ON TEST | 5| 3| 3| 5| 3| 3| 1| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 3| 8| 3| |
| 0| 5| 6| 9| 4| 6| 3| 6| 7| 6| 2| 6| 5| 5| 5| 6| 7| 7| 9| 8| 6| 2| 7| 1| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
.625% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Active | 2 2 | 3 1.7|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Basophilic Focus | X | 1 |
Inflammation, Chronic Active | | 2 1.5|
Acinus, Atrophy | 1 1 1 | 5 1.2|
Duct, Cyst | 2 2 | 4 2.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | | 5 1.6|
Basophilic Focus | X X | 6 |
Vacuolization Cytoplasmic | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | 3 | 2 3.5|
Epithelium, Hyperkeratosis | 2 | 1 2.0|
Epithelium, Hyperplasia | 2 | 2 2.0|
Epithelium, Ulcer | 4 | 2 4.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | 3 2 | 2 2.5|
Epithelium, Ulcer | 4 2 | 2 3.0|
Glands, Ectasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 39 1.0|
|__________________________________________________________________________|____________|
Tongue | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cardiomyopathy | 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 1 2 2 2 2 2| 43 1.9|
Mineralization | 1 | 1 1.0|
Valve, Thrombosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
__________________________________________________________________________________________________________________________________
| 0| 7| 7| 4| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 6| 7| |
DAY ON TEST | 5| 3| 3| 5| 3| 3| 1| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 3| 8| 3| |
| 0| 5| 6| 9| 4| 6| 3| 6| 7| 6| 2| 6| 5| 5| 5| 6| 7| 7| 9| 8| 6| 2| 7| 1| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
.625% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | | 2 1.0|
Hyperplasia | 1 1 2 1 1 2 2 1| 12 1.5|
Hypertrophy | 1 | 3 1.7|
Necrosis | 2 | 1 2.0|
Vacuolization Cytoplasmic | 1 1 4 4 3 1 2 1 1 2 1 1 1 | 19 1.6|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 | 3 2.3|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Angiectasis | 4 | 1 4.0|
Pars Distalis, Cyst | 2 2 2 1 2 1 1 3 1 2 | 19 1.9|
Pars Distalis, Hyperplasia | 2 4 2 2 2 1 1 1 3| 23 1.9|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Ultimobranchial Cyst | 2 | 2 1.5|
C-Cell, Hyperplasia | 1 1 1 1 1 1 3 1 1 1 1 2 1 1 2 2| 28 1.3|
Follicle, Cyst | | 1 2.0|
Follicular Cell, Hyperplasia | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 1 2 2 2 4 2 | 11 2.2|
Inflammation, Chronic Active | 1 1 3 1 1| 15 1.6|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
__________________________________________________________________________________________________________________________________
| 0| 7| 7| 4| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 6| 7| |
DAY ON TEST | 5| 3| 3| 5| 3| 3| 1| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 3| 8| 3| |
| 0| 5| 6| 9| 4| 6| 3| 6| 7| 6| 2| 6| 5| 5| 5| 6| 7| 7| 9| 8| 6| 2| 7| 1| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
.625% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Duct, Cyst | 4 2 2 2 | 9 2.6|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 2 4 4 | 4 3.0|
Mineralization | | 1 1.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hydrometra | 2 2 3 | 5 2.4|
Inflammation, Chronic Active | 1 | 1 1.0|
Endometrium, Hyperplasia, Cystic | 2 2 | 4 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 4 3 4 3 4 3 3 | 11 3.4|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + +| 24 |
Deep Cervical, Ectasia | 2 2 3 | 3 2.3|
Deep Cervical, Hyperplasia, Lymphoid | 3 2 2 | 3 2.3|
Deep Cervical, Pigmentation | 1 | 1 1.0|
Mediastinal, Ectasia | 2 2 2 2 2 2 2 2| 20 2.0|
Mediastinal, Hyperplasia, Lymphoid | 2 3 3 3 2 3 2 2| 20 2.3|
Mediastinal, Pigmentation | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M M M M| 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 2 | 3 2.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + M + + + + + + + + + + + +| 48 |
Ectopic Parathyroid Gland | 2 | 2 1.5|
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
__________________________________________________________________________________________________________________________________
| 0| 7| 7| 4| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 6| 7| |
DAY ON TEST | 5| 3| 3| 5| 3| 3| 1| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 3| 8| 3| |
| 0| 5| 6| 9| 4| 6| 3| 6| 7| 6| 2| 6| 5| 5| 5| 6| 7| 7| 9| 8| 6| 2| 7| 1| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
.625% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 4 | 3 4.0|
Hyperplasia, Cystic | 2 2 2 3 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2| 37 2.1|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Compression | 2 | 2 2.5|
Hemorrhage | | 2 1.5|
Hydrocephalus | 2 2 2| 5 2.0|
Inflammation, Chronic Active | | 1 2.0|
|__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
|__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
Hemorrhage | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 37 1.1|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 45 1.0|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 44 1.0|
Alveolar Epithelium, Hyperplasia | 1 2 1 | 13 1.5|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 44 1.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
__________________________________________________________________________________________________________________________________
| 0| 7| 7| 4| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 6| 7| |
DAY ON TEST | 5| 3| 3| 5| 3| 3| 1| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 3| 8| 3| |
| 0| 5| 6| 9| 4| 6| 3| 6| 7| 6| 2| 6| 5| 5| 5| 6| 7| 7| 9| 8| 6| 2| 7| 1| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
.625% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Nose | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Thrombosis | 4 | 1 4.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 4 2 3 2| 6 2.5|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | | 1 |
Retina, Hemorrhage | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 33 1.0|
Nephropathy | 2 2 3 1 1 1 1 1 1 2 1 2 2 1 2 2 1 1 1 1| 38 1.3|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Transitional Epithelium, Hyperplasia | | 1 3.0|
Transitional Epithelium, Metaplasia, | | |
Squamous | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 6| 7| 5| 6| 7| 7| 7| 6| 5| 6| 1| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 9| 3| 3| 3| 9| 3| 8| 7| 3| 3| 2| 3|
| 5| 5| 7| 6| 7| 7| 5| 5| 4| 7| 5| 5| 8| 4| 7| 7| 6| 7| 6| 1| 2| 6| 5| 6| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.25% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X|
Eosinophilic Focus | |
Fibrosis | |
Hematopoietic Cell Proliferation | 1 |
Hepatodiaphragmatic Nodule | X X X |
Inflammation, Chronic Active | 2 2 2 1 2 2 2 1 2 2 2 2 2 1 2 2 2 3 2 1|
Mixed Cell Focus | X X X X X X X X |
Necrosis | 2 2 |
Bile Duct, Hyperplasia | 2 1 1 2 1 |
Hepatocyte, Vacuolization Cytoplasmic| 2 1 1 4 1 2 1 1 1 |
|__________________________________________________________________________|
Mesentery | + + + |
Hemorrhage | |
Fat, Inflammation, Chronic | 3 3 |
Fat, Mineralization | 2 1 |
Fat, Necrosis | 4 4 4 |
Fat, Pigmentation | |
|__________________________________________________________________________|
Oral Mucosa | + + |
__________________________________________|__________________________________________________________________________|
Page 51
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 6| 7| 5| 6| 7| 7| 7| 6| 5| 6| 1| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 9| 3| 3| 3| 9| 3| 8| 7| 3| 3| 2| 3|
| 5| 5| 7| 6| 7| 7| 5| 5| 4| 7| 5| 5| 8| 4| 7| 7| 6| 7| 6| 1| 2| 6| 5| 6| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.25% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Foreign Body | X X |
Gingival, Inflammation, Chronic | |
Active | |
Gingival, Necrosis | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Acinus, Atrophy | 1 2 1 2 3 1 |
Acinus, Hyperplasia | |
Duct, Cyst | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 2 1 1 2 2 1 |
Basophilic Focus | X X |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Epithelium, Hyperkeratosis | 2 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Erosion | |
Glands, Ectasia | 1 1 1 1 1 1 2 2 1 2 1 2 1 2 1 1 1 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 2 2 2 2 2 2 2 2 2 2 1 2 1 2 2 2 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 |
Hematopoietic Cell Proliferation | 1 |
Hyperplasia | 2 1 2 2 |
Hypertrophy | 2 |
Necrosis | |
__________________________________________|__________________________________________________________________________|
Page 52
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 6| 7| 5| 6| 7| 7| 7| 6| 5| 6| 1| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 9| 3| 3| 3| 9| 3| 8| 7| 3| 3| 2| 3|
| 5| 5| 7| 6| 7| 7| 5| 5| 4| 7| 5| 5| 8| 4| 7| 7| 6| 7| 6| 1| 2| 6| 5| 6| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.25% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Vacuolization Cytoplasmic | 1 2 3 1 3 1 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + M + M + + + + + + + + + + + + M + M + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 2 3 2 2 2 2 2 2 1 1 2 |
Pars Distalis, Hemorrhage | |
Pars Distalis, Hyperplasia | 2 4 2 2 2 2 2 1 1 2 4 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 2 1 1 2 1 1 2 1 1 1 1 2 |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Peritoneum | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 2 2 |
Inflammation, Chronic Active | 2 1 1 1 1 |
Mineralization | |
Duct, Cyst | 3 4 2 2 2 |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
|__________________________________________________________________________|
Oviduct | + |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 2 |
__________________________________________|__________________________________________________________________________|
Page 53
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 6| 7| 5| 6| 7| 7| 7| 6| 5| 6| 1| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 9| 3| 3| 3| 9| 3| 8| 7| 3| 3| 2| 3|
| 5| 5| 7| 6| 7| 7| 5| 5| 4| 7| 5| 5| 8| 4| 7| 7| 6| 7| 6| 1| 2| 6| 5| 6| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.25% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Endometrium, Hyperplasia, Cystic | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 4 4 4 4 3 3 3 |
Myelofibrosis | 3 2 |
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + |
Deep Cervical, Hyperplasia, Lymphoid | 2 |
Mediastinal, Ectasia | 2 2 2 2 2 2 2 3 3 2 2 |
Mediastinal, Hyperplasia, Lymphoid | 2 3 2 2 3 2 3 2 3 2 3 2 |
Mediastinal, Pigmentation | 3 |
|__________________________________________________________________________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 3 3 |
Hyperplasia, Lymphoid | |
Pigmentation | 3 3 |
|__________________________________________________________________________|
Thymus | + M + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Parathyroid Gland | 1 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 1 2 3 2 3 2 2 1 2 2 3 2 3 2 2 2 2 1 2 2 2|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 54
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 6| 7| 5| 6| 7| 7| 7| 6| 5| 6| 1| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 9| 3| 3| 3| 9| 3| 8| 7| 3| 3| 2| 3|
| 5| 5| 7| 6| 7| 7| 5| 5| 4| 7| 5| 5| 8| 4| 7| 7| 6| 7| 6| 1| 2| 6| 5| 6| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.25% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
|__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 |
Hemorrhage | 1 1 |
Hydrocephalus | 3 |
Necrosis | |
Meninges, Inflammation, Chronic | |
Active | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Inflammation, Chronic Active | 2 1 1 1 2 1 1 2 1 1 1 1 1 1 2 1|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Alveolar Epithelium, Hyperplasia | 1 2 3 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X |
Inflammation, Chronic Active | 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | |
Lens, Cataract | |
Retina, Degeneration | |
__________________________________________|__________________________________________________________________________|
Page 55
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 6| 7| 5| 6| 7| 7| 7| 6| 5| 6| 1| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 9| 3| 3| 3| 9| 3| 8| 7| 3| 3| 2| 3|
| 5| 5| 7| 6| 7| 7| 5| 5| 4| 7| 5| 5| 8| 4| 7| 7| 6| 7| 6| 1| 2| 6| 5| 6| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.25% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | |
Infiltration Cellular, Lipocyte | |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 |
Nephropathy | 2 1 2 1 1 1 1 2 1 2 2 1 2 2 1 2 2 1 2 2|
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 56
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 6| 3| 3| 6| 3| 3| 3| 3| 2| 6| 9| 3| 3| 3| 4| 3| 3| 3| 3| 1| 3| 3| |
| 6| 7| 6| 4| 5| 5| 9| 6| 7| 5| 6| 3| 5| 0| 7| 5| 7| 3| 6| 7| 7| 6| 8| 7| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
1.25% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | | 1 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X | 1 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | | 1 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X| 44 |
Eosinophilic Focus | X | 1 |
Fibrosis | 2 | 1 2.0|
Hematopoietic Cell Proliferation | | 1 1.0|
Hepatodiaphragmatic Nodule | X X X X | 7 |
Inflammation, Chronic Active | 2 2 2 2 2 2 2 2 2 2 3 2 1 2 1 2 1 2 1 3 1 2 2| 43 1.9|
Mixed Cell Focus | X X X X X X X X X X X X | 20 |
Necrosis | 2 2 1 2 | 6 1.8|
Bile Duct, Hyperplasia | 2 1 1 1 1 1 1 1 1 1 1 1 1| 18 1.2|
Hepatocyte, Vacuolization Cytoplasmic| 1 1 1 1 1 1 1 1 2 | 18 1.3|
|__________________________________________________________________________|____________|
Mesentery | + + + + + | 8 |
Hemorrhage | 3 | 1 3.0|
Fat, Inflammation, Chronic | 3 3 2 3 2 | 7 2.7|
Fat, Mineralization | 2 | 3 1.7|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 6| 3| 3| 6| 3| 3| 3| 3| 2| 6| 9| 3| 3| 3| 4| 3| 3| 3| 3| 1| 3| 3| |
| 6| 7| 6| 4| 5| 5| 9| 6| 7| 5| 6| 3| 5| 0| 7| 5| 7| 3| 6| 7| 7| 6| 8| 7| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
1.25% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Fat, Necrosis | 4 4 4 4 | 7 4.0|
Fat, Pigmentation | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Oral Mucosa | + + +| 5 |
Foreign Body | X X| 4 |
Gingival, Inflammation, Chronic | | |
Active | 2 | 1 2.0|
Gingival, Necrosis | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 1 | 1 1.0|
Acinus, Atrophy | 2 1 2 1 2 | 11 1.6|
Acinus, Hyperplasia | 2 | 1 2.0|
Duct, Cyst | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 1 2 1 | 11 1.4|
Basophilic Focus | X | 3 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 | 1 2.0|
Epithelium, Hyperkeratosis | | 1 2.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Erosion | 1 | 1 1.0|
Glands, Ectasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 38 1.1|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 2 2 2 2 1 1 2 2 2 2 1 2 1 2 2 2 1 2 2 2 1 3 2 2| 44 1.8|
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 6| 3| 3| 6| 3| 3| 3| 3| 2| 6| 9| 3| 3| 3| 4| 3| 3| 3| 3| 1| 3| 3| |
| 6| 7| 6| 4| 5| 5| 9| 6| 7| 5| 6| 3| 5| 0| 7| 5| 7| 3| 6| 7| 7| 6| 8| 7| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
1.25% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | | 1 2.0|
Hematopoietic Cell Proliferation | | 1 1.0|
Hyperplasia | 1 2 1 1 2 1 | 10 1.5|
Hypertrophy | 2 | 2 2.0|
Necrosis | 4 | 1 4.0|
Vacuolization Cytoplasmic | 1 2 2 1 1 1 2 1 1 1 4 3 1 1| 20 1.7|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 3 | 3 1.7|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Cyst | 1 2 1 3 1 1 2 2 2 1 1 | 22 1.7|
Pars Distalis, Hemorrhage | 2 | 1 2.0|
Pars Distalis, Hyperplasia | 2 2 2 2 2 1 2 1 2 2| 21 2.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ultimobranchial Cyst | 1 | 1 1.0|
C-Cell, Hyperplasia | 1 1 1 2 1 1 1 2 2| 21 1.3|
Follicular Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Peritoneum | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 2 2 | 7 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 6| 3| 3| 6| 3| 3| 3| 3| 2| 6| 9| 3| 3| 3| 4| 3| 3| 3| 3| 1| 3| 3| |
| 6| 7| 6| 4| 5| 5| 9| 6| 7| 5| 6| 3| 5| 0| 7| 5| 7| 3| 6| 7| 7| 6| 8| 7| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
1.25% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Inflammation, Chronic Active | 1 1 1 1 1 2 1 | 12 1.2|
Mineralization | 1 | 1 1.0|
Duct, Cyst | 2 2 2 3 2 2 | 11 2.4|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 4 4 | 2 4.0|
|__________________________________________________________________________|____________|
Oviduct | | 1 |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrometra | 3 4 | 3 3.0|
Endometrium, Hyperplasia, Cystic | 2 2 2 | 4 2.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 4 4 3 4 3 | 13 3.6|
Myelofibrosis | 2 2 | 4 2.3|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + +| 27 |
Deep Cervical, Hyperplasia, Lymphoid | 2 3 | 3 2.3|
Mediastinal, Ectasia | 2 2 2 2 2 2 2 2 2 2| 21 2.1|
Mediastinal, Hyperplasia, Lymphoid | 2 2 2 2 2 2 3 2 2 2| 22 2.3|
Mediastinal, Pigmentation | 2 | 2 2.5|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M M M M M M M M M + M M M M M M + M M M M M M| 2 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 2 3 | 6 2.5|
Hyperplasia, Lymphoid | 4 | 1 4.0|
Pigmentation | | 2 3.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 6| 3| 3| 6| 3| 3| 3| 3| 2| 6| 9| 3| 3| 3| 4| 3| 3| 3| 3| 1| 3| 3| |
| 6| 7| 6| 4| 5| 5| 9| 6| 7| 5| 6| 3| 5| 0| 7| 5| 7| 3| 6| 7| 7| 6| 8| 7| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
1.25% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Thymus | + + + + + + M M + + + + + + + + + + + + + + + + +| 47 |
Ectopic Parathyroid Gland | 1 1 2 | 6 1.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Cystic | 2 2 2 3 2 2 2 2 2 2 2 1 3 3 2 2 3 2 2 2 1| 42 2.1|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | X | 1 |
Inflammation, Chronic Active | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 3 3 3 3 | 5 3.0|
Hemorrhage | 2 | 3 1.3|
Hydrocephalus | 2 3 2 2 2 3 2 | 8 2.4|
Necrosis | 2 | 1 2.0|
Meninges, Inflammation, Chronic | | |
Active | | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | | 1 2.0|
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 | 33 1.2|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 44 1.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 6| 3| 3| 6| 3| 3| 3| 3| 2| 6| 9| 3| 3| 3| 4| 3| 3| 3| 3| 1| 3| 3| |
| 6| 7| 6| 4| 5| 5| 9| 6| 7| 5| 6| 3| 5| 0| 7| 5| 7| 3| 6| 7| 7| 6| 8| 7| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
1.25% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 44 1.0|
Alveolar Epithelium, Hyperplasia | 1 2 1 2 2 | 9 1.7|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 45 1.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | | 1 |
Inflammation, Chronic Active | 2 | 2 2.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + +| 2 |
Lens, Cataract | 4 4| 2 4.0|
Retina, Degeneration | 4 3| 2 3.5|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct | 4 | 1 4.0|
Infiltration Cellular, Lipocyte | 2 | 1 2.0|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 30 1.0|
Nephropathy | 2 1 2 1 2 2 1 1 1 2 1 1 1 2 2 1 1 1 1 1| 40 1.5|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 1| 3| 3| 0| 3| 3| 0| 8| 3| 1| 3| 3| 5| 1| 0| 3| 1| 7| 3| 1| 3| 2| 3| 3|
| 1| 1| 2| 3| 3| 2| 3| 9| 3| 1| 0| 3| 2| 9| 0| 3| 3| 1| 3| 3| 5| 2| 4| 3| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X|
Clear Cell Focus | X |
Eosinophilic Focus | X |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X X|
Inflammation, Chronic Active | 1 1 1 1 1 2 2 2 1 1 1 1 1 1 2 1 3|
Mixed Cell Focus | X X X X X X X X X |
Necrosis | 2 2 |
Bile Duct, Cyst | 2 |
Bile Duct, Hyperplasia | 2 1 2 2 2 1 3 1 2 2 2 1 1 2 2 1 1 1 1 2 2 3 2|
Hepatocyte, Degeneration, Cystic | 1 1 |
Hepatocyte, Hyperplasia | 2 |
Hepatocyte, Vacuolization Cytoplasmic| 3 2 1 1 1 3 1 4 1 |
Portal, Fibrosis | 3 |
|__________________________________________________________________________|
Mesentery | + + + + + + + +|
Fat, Inflammation, Chronic | 3 3 3 3 3 3|
Fat, Mineralization | 1 2 1 1 2|
Fat, Necrosis | 4 4 4 4 4 4|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 63
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 1| 3| 3| 0| 3| 3| 0| 8| 3| 1| 3| 3| 5| 1| 0| 3| 1| 7| 3| 1| 3| 2| 3| 3|
| 1| 1| 2| 3| 3| 2| 3| 9| 3| 1| 0| 3| 2| 9| 0| 3| 3| 1| 3| 3| 5| 2| 4| 3| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Oral Mucosa | + + + + + + + |
Foreign Body | X X X X X X X |
Gingival, Inflammation, Chronic | |
Active | 2 2 2 2 2 1 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 1 1 1 1 2 1 1|
Duct, Cyst | 2 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 3 1 2 1 |
Basophilic Focus | X 1 X X X 1 X X |
Hyperplasia | 2 |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | |
Inflammation, Chronic Active | 2 3 |
Epithelium, Hyperkeratosis | 2 2 |
Epithelium, Hyperplasia | 2 2 3 |
Epithelium, Ulcer | 3 4 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Mineralization | |
Epithelium, Ulcer | 2 |
Glands, Ectasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
|__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Mineralization | |
Media, Mineralization | 2 |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 1 2 1 1|
Inflammation, Chronic Active | |
__________________________________________|__________________________________________________________________________|
Page 64
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 1| 3| 3| 0| 3| 3| 0| 8| 3| 1| 3| 3| 5| 1| 0| 3| 1| 7| 3| 1| 3| 2| 3| 3|
| 1| 1| 2| 3| 3| 2| 3| 9| 3| 1| 0| 3| 2| 9| 0| 3| 3| 1| 3| 3| 5| 2| 4| 3| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
Mineralization | |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Atypia Cellular | |
Hematopoietic Cell Proliferation | 1 |
Hyperplasia | 1 2 1 1 1 1 1 2 1|
Hypertrophy | 1 1 |
Vacuolization Cytoplasmic | 2 1 1 3 2 4 2 2 3 2 2 2 1 1 1 2|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + M + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 2 2 |
Pars Distalis, Hemorrhage | |
Pars Distalis, Hyperplasia | 1 2 1 2 1 1 2 2 |
Pars Distalis, Inflammation, | |
Suppurative | |
Pars Distalis, Mineralization | |
Pars Intermedia, Cyst | 2|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | 2 |
C-Cell, Hyperplasia | 1 2 1 1 1 1 1 1 1 1|
Follicle, Cyst | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 65
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 1| 3| 3| 0| 3| 3| 0| 8| 3| 1| 3| 3| 5| 1| 0| 3| 1| 7| 3| 1| 3| 2| 3| 3|
| 1| 1| 2| 3| 3| 2| 3| 9| 3| 1| 0| 3| 2| 9| 0| 3| 3| 1| 3| 3| 5| 2| 4| 3| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 2 2 |
Inflammation, Chronic Active | |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 2 2 |
Inflammation, Chronic Active | 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Mineralization | |
Duct, Ectasia | 3 4 |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Degeneration | 3 |
Inflammation, Chronic Active | 2 2 1 1 2 2 2 1 2|
Mineralization | 2 |
Epithelium, Hyperplasia | 1 |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Mineralization | 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 2 1|
Germinal Epithelium, Atrophy | |
Interstitial Cell, Hyperplasia | 2 1 1 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 4 3 4 4 4 4 4 3 4 4 3 3 3 3 4 |
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + +|
Ectasia | 3 2 |
Hyperplasia, Lymphoid | 2 |
Deep Cervical, Ectasia | 2 |
Deep Cervical, Hyperplasia, Lymphoid | 2 2 2 |
Mediastinal, Ectasia | 2 2 |
Mediastinal, Hyperplasia, Lymphoid | 2 2 3 3 |
__________________________________________|__________________________________________________________________________|
Page 66
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 1| 3| 3| 0| 3| 3| 0| 8| 3| 1| 3| 3| 5| 1| 0| 3| 1| 7| 3| 1| 3| 2| 3| 3|
| 1| 1| 2| 3| 3| 2| 3| 9| 3| 1| 0| 3| 2| 9| 0| 3| 3| 1| 3| 3| 5| 2| 4| 3| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Pancreatic, Ectasia | 2|
|__________________________________________________________________________|
Lymph Node, Mandibular | M M M + M M M M M M M M M M M M M M M M M M M M M|
Ectasia | 3 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 1 |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Lymphoid | 4 4|
|__________________________________________________________________________|
Thymus | + M + + + + + + + + M + + + + + + + M + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4|
Hyperplasia, Cystic | 2 1 1 1 1 2 2 2 1 1 1 1 2 2 1 3 2 3 1 1 2 2 4|
Inflammation, Chronic Active | 4|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 3 |
Inflammation, Chronic Active | |
Epidermis, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 3|
Hemorrhage | 1 2 2 2 4 |
__________________________________________|__________________________________________________________________________|
Page 67
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 1| 3| 3| 0| 3| 3| 0| 8| 3| 1| 3| 3| 5| 1| 0| 3| 1| 7| 3| 1| 3| 2| 3| 3|
| 1| 1| 2| 3| 3| 2| 3| 9| 3| 1| 0| 3| 2| 9| 0| 3| 3| 1| 3| 3| 5| 2| 4| 3| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM - cont | |
Hydrocephalus | 3 3|
Inflammation, Chronic Active | 1 |
Inflammation, Suppurative | |
Mineralization | |
Necrosis | 1 |
Pigmentation | 1 |
|__________________________________________________________________________|
Peripheral Nerve | + |
|__________________________________________________________________________|
Spinal Cord | + |
Hemorrhage | 4 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 2 1 1|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Necrosis | 4 |
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Alveolar Epithelium, Hyperplasia | 2 2 |
Alveolar Epithelium, Metaplasia, | |
Focal, Squamous | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 2 |
Keratin Cyst | X |
Thrombosis | 4 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 3 2 2 2 1 3 1 |
|__________________________________________________________________________|
Pleura | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 68
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 1| 3| 3| 0| 3| 3| 0| 8| 3| 1| 3| 3| 5| 1| 0| 3| 1| 7| 3| 1| 3| 2| 3| 3|
| 1| 1| 2| 3| 3| 2| 3| 9| 3| 1| 0| 3| 2| 9| 0| 3| 3| 1| 3| 3| 5| 2| 4| 3| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
Eye | |
Lens, Cataract | |
Lens, Degeneration | |
Retina, Degeneration | |
|__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Nephropathy | 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 3 1 3 2 1 1 2|
Medulla, Necrosis | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Chronic Active | |
__________________________________________|__________________________________________________________________________
Page 69
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 5| 7| 7| 7| 6| 7| 5| 5| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 9| 9| 8| 3| 0| 3| 3| 3| 9| 0| 3| 3| 2| 3| 3| 7| 3| 3| 3| 3| 3| 3| |
| 3| 1| 2| 6| 0| 6| 3| 9| 2| 1| 3| 8| 8| 1| 1| 4| 2| 2| 6| 2| 1| 2| 1| 2| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
UNTREATD | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X X | 3 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X X X X X X X | 10 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X| 25 |
Clear Cell Focus | | 1 |
Eosinophilic Focus | X | 2 |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hepatodiaphragmatic Nodule | | 2 |
Inflammation, Chronic Active | 1 2 1 2 2 1 1 3 1 2 1 1 1 2 2 1 2| 34 1.4|
Mixed Cell Focus | X X X X X X X X X| 18 |
Necrosis | | 2 2.0|
Bile Duct, Cyst | | 1 2.0|
Bile Duct, Hyperplasia | 2 3 2 2 1 2 3 2 2 2 3 3 2 2 1 2 2 2 1 2 1 2| 45 1.8|
Hepatocyte, Degeneration, Cystic | 1 1 | 4 1.0|
Hepatocyte, Hyperplasia | | 1 2.0|
Hepatocyte, Vacuolization Cytoplasmic| 1 3 1 1 2 2 3 1 1 1 1 1 1 1| 23 1.6|
Portal, Fibrosis | | 1 3.0|
|__________________________________________________________________________|____________|
Mesentery | + + + + + + | 14 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 70
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 5| 7| 7| 7| 6| 7| 5| 5| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 9| 9| 8| 3| 0| 3| 3| 3| 9| 0| 3| 3| 2| 3| 3| 7| 3| 3| 3| 3| 3| 3| |
| 3| 1| 2| 6| 0| 6| 3| 9| 2| 1| 3| 8| 8| 1| 1| 4| 2| 2| 6| 2| 1| 2| 1| 2| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
UNTREATD | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Fat, Inflammation, Chronic | 3 3 3 3 3 | 11 3.0|
Fat, Mineralization | 1 2 2 | 8 1.5|
Fat, Necrosis | 4 4 4 4 4 | 11 4.0|
|__________________________________________________________________________|____________|
Oral Mucosa | + + + + + +| 13 |
Foreign Body | X X X X X X| 13 |
Gingival, Inflammation, Chronic | | |
Active | 2 2 2 | 9 1.9|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 1 2 3 2 2| 13 1.5|
Duct, Cyst | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 1 2 | 8 1.5|
Basophilic Focus | X X X X X X X X | 16 1.0|
Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Diverticulum | X | 1 |
Inflammation, Chronic Active | 3 3 | 4 2.8|
Epithelium, Hyperkeratosis | | 2 2.0|
Epithelium, Hyperplasia | 2 2 | 5 2.2|
Epithelium, Ulcer | 4 4 4 | 5 3.8|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 2.0|
Mineralization | 2 | 1 2.0|
Epithelium, Ulcer | | 1 2.0|
Glands, Ectasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 34 1.0|
|__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 71
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 5| 7| 7| 7| 6| 7| 5| 5| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 9| 9| 8| 3| 0| 3| 3| 3| 9| 0| 3| 3| 2| 3| 3| 7| 3| 3| 3| 3| 3| 3| |
| 3| 1| 2| 6| 0| 6| 3| 9| 2| 1| 3| 8| 8| 1| 1| 4| 2| 2| 6| 2| 1| 2| 1| 2| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
UNTREATD | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Aorta, Mineralization | 1 | 1 1.0|
Media, Mineralization | | 1 2.0|
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 2 2 2 2 2 2 1 2 1 3 2 2 2 2 2 1 2 2 2 2 2 2| 44 1.9|
Inflammation, Chronic Active | 2 | 1 2.0|
Mineralization | 3 | 1 3.0|
Atrium, Thrombosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 2 | 1 2.0|
Atypia Cellular | 2 | 1 2.0|
Hematopoietic Cell Proliferation | | 1 1.0|
Hyperplasia | 1 2 1 | 12 1.3|
Hypertrophy | | 2 1.0|
Vacuolization Cytoplasmic | 2 2 2 2 1 1 1 1 1 1 3 1 1 1| 30 1.7|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 2 1 2 2| 8 1.9|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + M + + + + + + + + + + + + + + + + M| 47 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Cyst | | 2 2.0|
Pars Distalis, Hemorrhage | 4 | 1 4.0|
Pars Distalis, Hyperplasia | 3 2 2 2 2 2 2 1 | 16 1.8|
Pars Distalis, Inflammation, | | |
Suppurative | 2 | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 72
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 5| 7| 7| 7| 6| 7| 5| 5| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 9| 9| 8| 3| 0| 3| 3| 3| 9| 0| 3| 3| 2| 3| 3| 7| 3| 3| 3| 3| 3| 3| |
| 3| 1| 2| 6| 0| 6| 3| 9| 2| 1| 3| 8| 8| 1| 1| 4| 2| 2| 6| 2| 1| 2| 1| 2| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
UNTREATD | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Pars Distalis, Mineralization | 2 | 1 2.0|
Pars Intermedia, Cyst | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ultimobranchial Cyst | 2 2 | 3 2.0|
C-Cell, Hyperplasia | 2 1 1 1 1 2 1| 17 1.2|
Follicle, Cyst | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma Sperm | 2 | 3 2.0|
Inflammation, Chronic Active | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 3| 7 2.4|
Inflammation, Chronic Active | 1 2 2 2 1 1 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2| 49 1.9|
Mineralization | 1 1| 2 1.0|
Duct, Ectasia | 3 2 2 | 5 2.8|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 | 1 3.0|
Degeneration | | 1 3.0|
Inflammation, Chronic Active | 2 2 2 1 1 2 2 1 1 2 2 2| 21 1.7|
Mineralization | | 1 2.0|
Epithelium, Hyperplasia | 2 | 2 1.5|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 4.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 73
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 5| 7| 7| 7| 6| 7| 5| 5| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 9| 9| 8| 3| 0| 3| 3| 3| 9| 0| 3| 3| 2| 3| 3| 7| 3| 3| 3| 3| 3| 3| |
| 3| 1| 2| 6| 0| 6| 3| 9| 2| 1| 3| 8| 8| 1| 1| 4| 2| 2| 6| 2| 1| 2| 1| 2| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
UNTREATD | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 2 1 1 1 1 2| 42 1.1|
Germinal Epithelium, Atrophy | 4 3 4 4 | 4 3.8|
Interstitial Cell, Hyperplasia | 2 1 1 1 1 1 | 10 1.2|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 4 4 4 3 4 4 4 4 4 3 3 4 | 29 3.6|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + | 24 |
Ectasia | | 2 2.5|
Hyperplasia, Lymphoid | | 1 2.0|
Deep Cervical, Ectasia | 2 3 | 3 2.3|
Deep Cervical, Hyperplasia, Lymphoid | | 3 2.0|
Mediastinal, Ectasia | 3 2 2 3 | 6 2.3|
Mediastinal, Hyperplasia, Lymphoid | 2 2 2 | 7 2.3|
Pancreatic, Ectasia | | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M M M M +| 2 |
Ectasia | 3| 2 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | | 1 1.0|
Hematopoietic Cell Proliferation | 3 | 2 2.5|
Hyperplasia, Lymphoid | 3 | 3 3.7|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + M + M + + + + + + + + M + + + M + +| 43 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 74
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 5| 7| 7| 7| 6| 7| 5| 5| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 9| 9| 8| 3| 0| 3| 3| 3| 9| 0| 3| 3| 2| 3| 3| 7| 3| 3| 3| 3| 3| 3| |
| 3| 1| 2| 6| 0| 6| 3| 9| 2| 1| 3| 8| 8| 1| 1| 4| 2| 2| 6| 2| 1| 2| 1| 2| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
UNTREATD | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
Cyst | | 1 4.0|
Hyperplasia, Cystic | 1 1 1 2 2 2 1 2 2 1 2 2 1 1 2 2 2 2 2 2 2 2| 45 1.7|
Inflammation, Chronic Active | | 1 4.0|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis | | 1 3.0|
Inflammation, Chronic Active | 4 | 1 4.0|
Epidermis, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 3 | 3 3.0|
Hemorrhage | 1 | 6 2.0|
Hydrocephalus | 3 2 | 4 2.8|
Inflammation, Chronic Active | | 1 1.0|
Inflammation, Suppurative | 2 | 1 2.0|
Mineralization | 1 | 1 1.0|
Necrosis | 4 3 | 3 2.7|
Pigmentation | | 1 1.0|
|__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
|__________________________________________________________________________|____________|
Spinal Cord | | 1 |
Hemorrhage | | 1 4.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 75
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 5| 7| 7| 7| 6| 7| 5| 5| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 9| 9| 8| 3| 0| 3| 3| 3| 9| 0| 3| 3| 2| 3| 3| 7| 3| 3| 3| 3| 3| 3| |
| 3| 1| 2| 6| 0| 6| 3| 9| 2| 1| 3| 8| 8| 1| 1| 4| 2| 2| 6| 2| 1| 2| 1| 2| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
UNTREATD | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1 2| 26 1.1|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 45 1.0|
Necrosis | | 1 4.0|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 30 1.0|
Alveolar Epithelium, Hyperplasia | 3 2 2 3 1 2 2| 9 2.1|
Alveolar Epithelium, Metaplasia, | | |
Focal, Squamous | 1| 1 1.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1| 31 1.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 2 2.0|
Keratin Cyst | | 1 |
Thrombosis | | 1 4.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 1 2 3 2 | 12 2.0|
|__________________________________________________________________________|____________|
Pleura | + | 1 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + | 2 |
Lens, Cataract | 4 | 1 4.0|
Lens, Degeneration | 4 | 1 4.0|
Retina, Degeneration | 4 4 | 2 4.0|
|__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 76
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 5| 7| 7| 7| 6| 7| 5| 5| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 9| 9| 8| 3| 0| 3| 3| 3| 9| 0| 3| 3| 2| 3| 3| 7| 3| 3| 3| 3| 3| 3| |
| 3| 1| 2| 6| 0| 6| 3| 9| 2| 1| 3| 8| 8| 1| 1| 4| 2| 2| 6| 2| 1| 2| 1| 2| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
UNTREATD | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
Hydronephrosis | 2 | 1 2.0|
Mineralization | 1 1 1 1 1 1 1 1 1 3 1 1 1 1 1 1 1 1 1 | 38 1.1|
Nephropathy | 1 2 2 3 3 1 2 2 2 2 1 2 1 1 1 3 2 1 2 2 1 2 1 2| 47 1.8|
Medulla, Necrosis | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 1 2.0|
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 77
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 4| 6| 5| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 5|
DAY ON TEST | 2| 3| 0| 3| 3| 4| 3| 3| 3| 3| 3| 9| 2| 5| 3| 3| 3| 3| 3| 0| 3| 9| 3| 3| 7|
| 4| 3| 6| 3| 1| 7| 3| 3| 3| 1| 3| 9| 4| 4| 1| 1| 1| 2| 2| 7| 3| 8| 7| 1| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X X X X X X X X X X X X|
Clear Cell Focus | X |
Eosinophilic Focus | |
Hematopoietic Cell Proliferation | 1 |
Hepatodiaphragmatic Nodule | X |
Inflammation, Chronic Active | 1 2 1 2 2 1 1 1 1 1 1 1 1 2 2 2 2 1 2 1|
Mixed Cell Focus | X X X X X X X X X X X X X X X X|
Necrosis | 2 3 |
Pigmentation | |
Bile Duct, Cyst | |
Bile Duct, Hyperplasia | 2 1 1 3 2 1 2 2 2 1 1 3 2 1 2 2 2 3 1 2 1 2 |
Hepatocyte, Degeneration, Cystic | 1 1 1 1 |
Hepatocyte, Hyperplasia | 2 |
Hepatocyte, Vacuolization Cytoplasmic| 1 2 3 1 1 1 1 1 3 1 1 1 1 2 1 2 1 1|
|__________________________________________________________________________|
Mesentery | + + |
Fat, Inflammation, Chronic | 3 3 |
Fat, Mineralization | 1 2 |
Fat, Necrosis | 4 4 |
__________________________________________|__________________________________________________________________________|
Page 78
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 4| 6| 5| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 5|
DAY ON TEST | 2| 3| 0| 3| 3| 4| 3| 3| 3| 3| 3| 9| 2| 5| 3| 3| 3| 3| 3| 0| 3| 9| 3| 3| 7|
| 4| 3| 6| 3| 1| 7| 3| 3| 3| 1| 3| 9| 4| 4| 1| 1| 1| 2| 2| 7| 3| 8| 7| 1| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + + |
Foreign Body | X X X X X X |
Gingival, Inflammation, Chronic | |
Active | 2 2 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Inflammation, Chronic Active | |
Pigmentation | |
Acinus, Atrophy | 1 1 1 1 1 1 2 3 2 2 1 1 |
Duct, Cyst | 2 2 2 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Basophilic Focus | X X 1 X 1 X X X |
Inflammation, Chronic Active | 1|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 2 |
Epithelium, Hyperkeratosis | 3 |
Epithelium, Hyperplasia | 3 2 |
Epithelium, Ulcer | 4 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Epithelium, Erosion | 2 1 1 |
Epithelium, Ulcer | 4 |
Glands, Ectasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Mineralization | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2|
Atrium, Thrombosis | 2 3 |
__________________________________________|__________________________________________________________________________|
Page 79
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 4| 6| 5| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 5|
DAY ON TEST | 2| 3| 0| 3| 3| 4| 3| 3| 3| 3| 3| 9| 2| 5| 3| 3| 3| 3| 3| 0| 3| 9| 3| 3| 7|
| 4| 3| 6| 3| 1| 7| 3| 3| 3| 1| 3| 9| 4| 4| 1| 1| 1| 2| 2| 7| 3| 8| 7| 1| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 1 |
Hyperplasia | 1 1 1 2 1 1|
Hypertrophy | 2 2 |
Necrosis | 2 2 |
Vacuolization Cytoplasmic | 1 2 2 2 1 4 1 3 1 1 1 1 1 1 1 1 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
|__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + M + + + + M + + + M + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 |
Pars Distalis, Cyst | 2 3 |
Pars Distalis, Hyperplasia | 1 1 2 2 1 |
Pars Intermedia, Cyst | |
Pars Intermedia, Hyperplasia | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 2 1 3 2 1 1 1 1 2 |
Follicle, Cyst | 2 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Peritoneum | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 80
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 4| 6| 5| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 5|
DAY ON TEST | 2| 3| 0| 3| 3| 4| 3| 3| 3| 3| 3| 9| 2| 5| 3| 3| 3| 3| 3| 0| 3| 9| 3| 3| 7|
| 4| 3| 6| 3| 1| 7| 3| 3| 3| 1| 3| 9| 4| 4| 1| 1| 1| 2| 2| 7| 3| 8| 7| 1| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Diffuse, | |
Suppurative | 4 |
Inflammation, Chronic Active | 1 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2|
Duct, Ectasia | 2 3 2 2 2|
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Chronic Active | 3 1 1 2 2 1 1 1 2 1 1 1 1 1 2|
Mineralization | |
Epithelium, Hyperplasia | 1 2 |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 1 2 1 1 1 1 1 1 2 1 1 1 2 1 1 1 1 1 1|
Germinal Epithelium, Atrophy | 4 |
Interstitial Cell, Hyperplasia | 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 3 4 3 4 4 3 3 3 3 3 4 4 3 4|
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + |
Deep Cervical, Hyperplasia, Lymphoid | 2 |
Mediastinal, Ectasia | 2 2 2 2 2 3 |
Mediastinal, Hyperplasia, Lymphoid | 3 2 2 2 2 2 |
|__________________________________________________________________________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 4 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 4 2 |
Hyperplasia, Lymphoid | |
__________________________________________|__________________________________________________________________________|
Page 81
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 4| 6| 5| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 5|
DAY ON TEST | 2| 3| 0| 3| 3| 4| 3| 3| 3| 3| 3| 9| 2| 5| 3| 3| 3| 3| 3| 0| 3| 9| 3| 3| 7|
| 4| 3| 6| 3| 1| 7| 3| 3| 3| 1| 3| 9| 4| 4| 1| 1| 1| 2| 2| 7| 3| 8| 7| 1| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Infarct | |
Necrosis | |
Pigmentation | |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + M + M + + M + + M + +|
Ectopic Parathyroid Gland | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 3 2 1 1 1 1 1 1 1 1 2 1 2 1 3 1 2 1 1 2 2 1 2|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 2 |
Hemorrhage | |
Hydrocephalus | 2 2 2 |
|__________________________________________________________________________|
Peripheral Nerve | |
|__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 2 1 1 1 2 1 2 1 2 1 1 1 1 2 1 1 2|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Alveolar Epithelium, Hyperplasia | 1 3 1 2 2|
__________________________________________|__________________________________________________________________________|
Page 82
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 4| 6| 5| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 5|
DAY ON TEST | 2| 3| 0| 3| 3| 4| 3| 3| 3| 3| 3| 9| 2| 5| 3| 3| 3| 3| 3| 0| 3| 9| 3| 3| 7|
| 4| 3| 6| 3| 1| 7| 3| 3| 3| 1| 3| 9| 4| 4| 1| 1| 1| 2| 2| 7| 3| 8| 7| 1| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X |
Inflammation, Chronic Active | 2 2 2 |
Thrombosis | |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 3 3 1 1 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + |
Lens, Cataract | 4 |
Retina, Degeneration | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accumulation, Hyaline Droplet | |
Cyst | 4 |
Inflammation, Chronic Active | |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Necrosis | |
Nephropathy | 1 3 1 2 2 2 2 1 2 2 2 2 1 2 1 3 1 1 2 2 1 2 1|
Cortex, Medulla, Fibrosis | |
Cortex, Medulla, Pigmentation | |
Cortex, Medulla, Pelvis, Cyst | |
Medulla, Renal Tubule, Dilatation | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 83
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 6| 5| 7| 7| 6| 7| 7| 7| 4| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 3| 3| 0| 5| 7| 3| 3| 0| 3| 3| 3| 2| 0| 3| 3| 5| 0| 3| 3| 3| 3| 3| 7| 3| 3| |
| 1| 2| 5| 3| 7| 3| 3| 6| 3| 3| 2| 9| 6| 2| 3| 5| 8| 1| 2| 1| 2| 2| 7| 2| 3| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
VEHICLE | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X | 4 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X | 4 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 | 1 3.0|
Basophilic Focus | X X X X X X X X X X X | 26 |
Clear Cell Focus | | 1 |
Eosinophilic Focus | X | 1 |
Hematopoietic Cell Proliferation | | 1 1.0|
Hepatodiaphragmatic Nodule | X | 2 |
Inflammation, Chronic Active | 2 1 2 1 1 2 2 2 1 2 1 2 2 2 2 1 1 2| 38 1.5|
Mixed Cell Focus | X X X X X X X X X X X X X| 29 |
Necrosis | 3 1 1 | 5 2.0|
Pigmentation | 2 | 1 2.0|
Bile Duct, Cyst | 2 | 1 2.0|
Bile Duct, Hyperplasia | 1 1 2 1 3 2 2 1 2 2 2 1 1 2 2 1 1 2 2 2 3 1 3 2| 46 1.8|
Hepatocyte, Degeneration, Cystic | 1 1 2 | 7 1.1|
Hepatocyte, Hyperplasia | | 1 2.0|
Hepatocyte, Vacuolization Cytoplasmic| 1 1 3 1 3 1 1 1 1 1 1 3 1 1 2 2 1 1 1| 37 1.4|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 84
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 6| 5| 7| 7| 6| 7| 7| 7| 4| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 3| 3| 0| 5| 7| 3| 3| 0| 3| 3| 3| 2| 0| 3| 3| 5| 0| 3| 3| 3| 3| 3| 7| 3| 3| |
| 1| 2| 5| 3| 7| 3| 3| 6| 3| 3| 2| 9| 6| 2| 3| 5| 8| 1| 2| 1| 2| 2| 7| 2| 3| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
VEHICLE | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Mesentery | + + + | 5 |
Fat, Inflammation, Chronic | | 2 3.0|
Fat, Mineralization | | 2 1.5|
Fat, Necrosis | | 2 4.0|
|__________________________________________________________________________|____________|
Oral Mucosa | + + + + + + | 13 |
Foreign Body | X X X X X X | 12 |
Gingival, Inflammation, Chronic | | |
Active | 2 2 | 4 2.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X | 1 |
Inflammation, Chronic Active | 2 | 1 2.0|
Pigmentation | 1 | 1 1.0|
Acinus, Atrophy | 1 1 1 4 2 2 1 2 1 2 1 2 1| 25 1.5|
Duct, Cyst | | 3 2.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 1 1 2 | 5 1.6|
Basophilic Focus | X X X X X X 1 X X X X| 19 1.0|
Inflammation, Chronic Active | | 1 1.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 3 | 3 2.3|
Epithelium, Hyperkeratosis | | 1 3.0|
Epithelium, Hyperplasia | 2 | 3 2.3|
Epithelium, Ulcer | 4 | 2 4.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 | 2 2.0|
Epithelium, Erosion | 1 | 4 1.3|
Epithelium, Ulcer | | 1 4.0|
Glands, Ectasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 34 1.0|
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 85
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 6| 5| 7| 7| 6| 7| 7| 7| 4| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 3| 3| 0| 5| 7| 3| 3| 0| 3| 3| 3| 2| 0| 3| 3| 5| 0| 3| 3| 3| 3| 3| 7| 3| 3| |
| 1| 2| 5| 3| 7| 3| 3| 6| 3| 3| 2| 9| 6| 2| 3| 5| 8| 1| 2| 1| 2| 2| 7| 2| 3| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
VEHICLE | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Aorta, Mineralization | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 46 2.0|
Atrium, Thrombosis | 2 | 3 2.3|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | | 2 1.0|
Hyperplasia | 1 1 2 | 9 1.2|
Hypertrophy | 2 | 3 2.0|
Necrosis | | 2 2.0|
Vacuolization Cytoplasmic | 1 1 3 3 1 1 2 2 1 2 1 | 27 1.6|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 3 2 2 2 2| 9 2.1|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + M + + + + + + + + + + +| 45 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | | 1 3.0|
Pars Distalis, Cyst | 2 2 | 4 2.3|
Pars Distalis, Hyperplasia | 2 1 2 2 1 2 1 1 | 13 1.5|
Pars Intermedia, Cyst | 1 2 | 2 1.5|
Pars Intermedia, Hyperplasia | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ultimobranchial Cyst | 1 | 1 1.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 86
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 6| 5| 7| 7| 6| 7| 7| 7| 4| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 3| 3| 0| 5| 7| 3| 3| 0| 3| 3| 3| 2| 0| 3| 3| 5| 0| 3| 3| 3| 3| 3| 7| 3| 3| |
| 1| 2| 5| 3| 7| 3| 3| 6| 3| 3| 2| 9| 6| 2| 3| 5| 8| 1| 2| 1| 2| 2| 7| 2| 3| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
VEHICLE | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
C-Cell, Hyperplasia | 1 1 1 1 2 2 2 1 2 1 1 3 1| 22 1.5|
Follicle, Cyst | 2 | 2 2.0|
Follicular Cell, Hyperplasia | 1 1 1 | 3 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Peritoneum | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma Sperm | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic, Diffuse, | | |
Suppurative | | 1 4.0|
Inflammation, Chronic Active | 2 2 2 2 2 2 2 2 2 1 4 2 2 2 2 2 2 2 2 2 2| 43 2.0|
Duct, Ectasia | 2 2 | 7 2.1|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 3 3| 3 2.7|
Inflammation, Chronic Active | 2 1 2 1 4 1 1 1 | 23 1.5|
Mineralization | 2| 1 2.0|
Epithelium, Hyperplasia | 2 2| 4 1.8|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 1 2 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 | 38 1.1|
Germinal Epithelium, Atrophy | | 1 4.0|
Interstitial Cell, Hyperplasia | 1 1 | 8 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 87
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 6| 5| 7| 7| 6| 7| 7| 7| 4| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 3| 3| 0| 5| 7| 3| 3| 0| 3| 3| 3| 2| 0| 3| 3| 5| 0| 3| 3| 3| 3| 3| 7| 3| 3| |
| 1| 2| 5| 3| 7| 3| 3| 6| 3| 3| 2| 9| 6| 2| 3| 5| 8| 1| 2| 1| 2| 2| 7| 2| 3| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
VEHICLE | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 4 4 4 4 4 3 4 4 3 3 3 3 3 3 4 4 3 3| 33 3.5|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + | 20 |
Deep Cervical, Hyperplasia, Lymphoid | | 1 2.0|
Mediastinal, Ectasia | 2 2 2 2 | 10 2.1|
Mediastinal, Hyperplasia, Lymphoid | 2 2 2 2 | 10 2.1|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M M M M M| |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 1 4.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 2 | 5 2.4|
Hyperplasia, Lymphoid | 4 2 | 2 3.0|
Infarct | 4 | 1 4.0|
Necrosis | 2 | 1 2.0|
Pigmentation | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + M M + + + + + + + + +| 44 |
Ectopic Parathyroid Gland | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Cystic | 2 2 1 1 1 3 1 1 2 1 1 1 1 1 1 2 1 1 1 1 2 1 1 1| 47 1.4|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 88
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 6| 5| 7| 7| 6| 7| 7| 7| 4| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 3| 3| 0| 5| 7| 3| 3| 0| 3| 3| 3| 2| 0| 3| 3| 5| 0| 3| 3| 3| 3| 3| 7| 3| 3| |
| 1| 2| 5| 3| 7| 3| 3| 6| 3| 3| 2| 9| 6| 2| 3| 5| 8| 1| 2| 1| 2| 2| 7| 2| 3| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
VEHICLE | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | | 2 2.0|
Hemorrhage | 3 | 1 3.0|
Hydrocephalus | | 3 2.0|
|__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
|__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 1 2 2 1 1 1 1 1 1 1 1 1 1 1| 32 1.3|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 46 1.0|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1| 35 1.0|
Alveolar Epithelium, Hyperplasia | 2 2 3 2 3| 10 2.1|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 3 1 1 1| 36 1.1|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X | 2 |
Inflammation, Chronic Active | 1 | 4 1.8|
Thrombosis | 3 4 | 2 3.5|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 1 | 6 1.8|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 89
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 6| 5| 7| 7| 6| 7| 7| 7| 4| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 3| 3| 0| 5| 7| 3| 3| 0| 3| 3| 3| 2| 0| 3| 3| 5| 0| 3| 3| 3| 3| 3| 7| 3| 3| |
| 1| 2| 5| 3| 7| 3| 3| 6| 3| 3| 2| 9| 6| 2| 3| 5| 8| 1| 2| 1| 2| 2| 7| 2| 3| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
VEHICLE | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Eye | | 1 |
Lens, Cataract | | 1 4.0|
Retina, Degeneration | | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accumulation, Hyaline Droplet | 3 | 1 3.0|
Cyst | | 1 4.0|
Inflammation, Chronic Active | 2 | 1 2.0|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 31 1.0|
Necrosis | 3 | 1 3.0|
Nephropathy | 2 1 2 2 2 2 2 2 2 2 1 1 2 2 2 1 2 2 2 2 2 1 2 1| 47 1.7|
Cortex, Medulla, Fibrosis | 3 | 1 3.0|
Cortex, Medulla, Pigmentation | 3 | 1 3.0|
Cortex, Medulla, Pelvis, Cyst | 3 | 1 3.0|
Medulla, Renal Tubule, Dilatation | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 90
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 6| 6| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 7| 3| 3| 9| 3| 3| 3| 3| 3| 8| 8| 4| 3|
| 2| 3| 3| 1| 1| 1| 3| 2| 4| 1| 2| 3| 2| 2| 3| 1| 1| 1| 3| 1| 3| 2| 2| 3| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
.312% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X |
Hepatodiaphragmatic Nodule | |
Inflammation, Chronic Active | 1 2 2 2 2 2 2 2 1 1 3 2 3 2 2 1 2 2 2 2 |
Mixed Cell Focus | X X X X X X X X X X X X X X X X |
Necrosis | 3 |
Thrombosis | |
Bile Duct, Hyperplasia | 2 2 1 2 2 2 1 2 1 2 2 2 2 2 2 2 2 2 2 2 1 2|
Hepatocyte, Degeneration, Cystic | 2 |
Hepatocyte, Hyperplasia | |
Hepatocyte, Vacuolization Cytoplasmic| 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 2 |
|__________________________________________________________________________|
Mesentery | + + + + + |
Fat, Inflammation, Chronic | 3 3 |
Fat, Mineralization | 2 |
Fat, Necrosis | 4 4 |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + |
Foreign Body | X X X X |
Gingival, Inflammation, Chronic | |
Active | 2 4 2 2 |
__________________________________________|__________________________________________________________________________|
Page 91
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 6| 6| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 7| 3| 3| 9| 3| 3| 3| 3| 3| 8| 8| 4| 3|
| 2| 3| 3| 1| 1| 1| 3| 2| 4| 1| 2| 3| 2| 2| 3| 1| 1| 1| 3| 1| 3| 2| 2| 3| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
.312% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Inflammation, Chronic Active | |
Metaplasia, Hepatocyte | 2 |
Acinus, Atrophy | 1 1 2 2 1 2 3|
Acinus, Hyperplasia | |
Duct, Cyst | 2 2 3 3 2 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2|
Basophilic Focus | X X X X X |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
Mineralization | |
Epithelium, Hyperkeratosis | 3 2 |
Epithelium, Hyperplasia | 3 2 2 |
Epithelium, Ulcer | 4 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Epithelium, Erosion | |
Epithelium, Hyperplasia | |
Epithelium, Necrosis | 2 |
Glands, Ectasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 1 |
__________________________________________|__________________________________________________________________________|
Page 92
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 6| 6| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 7| 3| 3| 9| 3| 3| 3| 3| 3| 8| 8| 4| 3|
| 2| 3| 3| 1| 1| 1| 3| 2| 4| 1| 2| 3| 2| 2| 3| 1| 1| 1| 3| 1| 3| 2| 2| 3| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
.312% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Hematopoietic Cell Proliferation | 1 1 |
Hyperplasia | 2 2 2 2 2 1 1 |
Hypertrophy | 1 1 |
Vacuolization Cytoplasmic | 1 1 1 1 1 1 1 2 2 2 1 1 2 1 1|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 1 2 1 2|
Thrombosis | |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + M + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 2 2 3 |
Pars Distalis, Hyperplasia | 3 2 1 2 3 3 2 1 1|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 1 1 1 1 2|
Follicle, Cyst | 2 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Peritoneum | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 2 2|
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
Inflammation, Chronic Active | 2 2 2 1 2 2 2 2 1 1 2 2 2 2 1 2 2 2 2 2 3 2 2 2|
Duct, Ectasia | 2 2|
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Inflammation, Chronic Active | 2 1 1 1 1 1 2 1 2 2 |
__________________________________________|__________________________________________________________________________|
Page 93
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 6| 6| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 7| 3| 3| 9| 3| 3| 3| 3| 3| 8| 8| 4| 3|
| 2| 3| 3| 1| 1| 1| 3| 2| 4| 1| 2| 3| 2| 2| 3| 1| 1| 1| 3| 1| 3| 2| 2| 3| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
.312% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Mineralization | |
Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 1 1 1 1 1 2 1 1 1 1 1 1 2 1 1 1 1 1 1 1 2|
Interstitial Cell, Hyperplasia | 1 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 3 3 4 4 3 3 4 4 4 4|
Myeloid Cell, Hyperplasia | 4 |
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + +|
Ectasia | |
Bronchial, Ectasia | 2 |
Bronchial, Hyperplasia, Lymphoid | 2 |
Deep Cervical, Ectasia | 2 |
Deep Cervical, Hyperplasia, Lymphoid | 2 |
Mediastinal, Ectasia | 2 2 2 2 3|
Mediastinal, Hyperplasia, Lymphoid | 3 2 2 2 |
Mediastinal, Pigmentation | |
|__________________________________________________________________________|
Lymph Node, Mandibular | M M M M M M M M M M + M M M M M M M M + M M M M M|
Ectasia | 3 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 2 2 2 2 3 2 |
Hyperplasia, Lymphoid | 3 |
Infarct | |
Lymphoid Follicle, Depletion Cellular| |
__________________________________________|__________________________________________________________________________|
Page 94
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 6| 6| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 7| 3| 3| 9| 3| 3| 3| 3| 3| 8| 8| 4| 3|
| 2| 3| 3| 1| 1| 1| 3| 2| 4| 1| 2| 3| 2| 2| 3| 1| 1| 1| 3| 1| 3| 2| 2| 3| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
.312% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + M + + M +|
Ectopic Parathyroid Gland | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 1 2 1 1 1 2 1 1 2 1 1 2 2 2 1 1 2 1 1 1 1|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Inflammation, Granulomatous | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | 3|
|__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 |
Hemorrhage | 2 3 |
Hydrocephalus | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Chronic Active | 1 1 3 1 1 2 1 1 1 1 1 1 1 1 1 1 |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Thrombosis | 2 |
Alveolar Epithelium, Hyperplasia | 2 2 2 1 2 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 3 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________|__________________________________________________________________________|
Page 95
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 6| 6| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 7| 3| 3| 9| 3| 3| 3| 3| 3| 8| 8| 4| 3|
| 2| 3| 3| 1| 1| 1| 3| 2| 4| 1| 2| 3| 2| 2| 3| 1| 1| 1| 3| 1| 3| 2| 2| 3| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
.312% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Inflammation, Chronic Active | |
Thrombosis | 4 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + |
Cornea, Inflammation, Chronic Active | 3 |
Cornea, Inflammation, Suppurative | |
Lens, Cataract | 3 |
|__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accumulation, Hyaline Droplet | 3 |
Infarct | |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Nephropathy | 2 2 2 2 2 1 2 2 1 2 2 2 1 2 2 1 2 2 2 2 2 1 1 1 2|
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
__________________________________________|__________________________________________________________________________
Page 96
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
__________________________________________________________________________________________________________________________________
| 7| 1| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 5| 7| |
DAY ON TEST | 3| 7| 1| 3| 8| 3| 3| 1| 3| 3| 3| 2| 3| 3| 3| 3| 9| 3| 3| 3| 3| 4| 3| 9| 3| |
| 2| 0| 0| 3| 0| 3| 1| 9| 3| 2| 1| 5| 1| 1| 3| 3| 0| 3| 2| 3| 1| 8| 2| 3| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
.312% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X X | 3 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X| 5 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X X X X| 32 |
Hepatodiaphragmatic Nodule | X | 1 |
Inflammation, Chronic Active | 1 1 1 2 1 2 2 2 1 2 2 2 1 2 1 2 1 2| 38 1.7|
Mixed Cell Focus | X X X X X X X X X X X X X X X X| 32 |
Necrosis | 2 | 2 2.5|
Thrombosis | 3 | 1 3.0|
Bile Duct, Hyperplasia | 2 3 1 2 2 1 1 2 2 1 2 2 1 2 2 1 2 1 2 2 2 2 2| 45 1.8|
Hepatocyte, Degeneration, Cystic | 1 1 | 3 1.3|
Hepatocyte, Hyperplasia | 3 | 1 3.0|
Hepatocyte, Vacuolization Cytoplasmic| 1 1 2 1 1 3 1 1 2 1 1 1 1 1 1 1 1 1 3 1| 36 1.2|
|__________________________________________________________________________|____________|
Mesentery | + + + | 8 |
Fat, Inflammation, Chronic | 4 | 3 3.3|
Fat, Mineralization | 3 | 2 2.5|
Fat, Necrosis | 4 | 3 4.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 97
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
__________________________________________________________________________________________________________________________________
| 7| 1| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 5| 7| |
DAY ON TEST | 3| 7| 1| 3| 8| 3| 3| 1| 3| 3| 3| 2| 3| 3| 3| 3| 9| 3| 3| 3| 3| 4| 3| 9| 3| |
| 2| 0| 0| 3| 0| 3| 1| 9| 3| 2| 1| 5| 1| 1| 3| 3| 0| 3| 2| 3| 1| 8| 2| 3| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
.312% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Oral Mucosa | + + + + + + + +| 14 |
Foreign Body | X X X X X X X X| 12 |
Gingival, Inflammation, Chronic | | |
Active | 2 1 1 1 1| 9 1.8|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X | 2 |
Inflammation, Chronic Active | 2 | 1 2.0|
Metaplasia, Hepatocyte | | 1 2.0|
Acinus, Atrophy | 1 2 2 1 2 1 2 1 1 1 2 2 1| 20 1.6|
Acinus, Hyperplasia | 2 4 | 2 3.0|
Duct, Cyst | 2 1 | 7 2.1|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 1 1 1 1 | 7 1.4|
Basophilic Focus | X X X X X| 10 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 3.0|
Mineralization | 2 | 1 2.0|
Epithelium, Hyperkeratosis | | 2 2.5|
Epithelium, Hyperplasia | | 3 2.3|
Epithelium, Ulcer | | 1 4.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 2 | 2 2.0|
Epithelium, Erosion | 2 1 | 2 1.5|
Epithelium, Hyperplasia | 3 | 1 3.0|
Epithelium, Necrosis | | 1 2.0|
Glands, Ectasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1| 37 1.1|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 98
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
__________________________________________________________________________________________________________________________________
| 7| 1| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 5| 7| |
DAY ON TEST | 3| 7| 1| 3| 8| 3| 3| 1| 3| 3| 3| 2| 3| 3| 3| 3| 9| 3| 3| 3| 3| 4| 3| 9| 3| |
| 2| 0| 0| 3| 0| 3| 1| 9| 3| 2| 1| 5| 1| 1| 3| 3| 0| 3| 2| 3| 1| 8| 2| 3| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
.312% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 1 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 46 1.9|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | | 2 1.5|
Hematopoietic Cell Proliferation | 1 1 1 | 5 1.0|
Hyperplasia | 2 1 2 1 2 1 2 2 2 | 16 1.7|
Hypertrophy | | 2 1.0|
Vacuolization Cytoplasmic | 2 1 3 2 3 1 1 1 2 1 2 2 2 1 3 | 30 1.5|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 2 1 1 2 2 1 | 14 1.6|
Thrombosis | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + M + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Cyst | 3 2 2 | 6 2.3|
Pars Distalis, Hyperplasia | 2 1 3 2 1 3 2| 16 2.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 2 2 1 1 2 1 1 2 1 1 2 2 | 20 1.4|
Follicle, Cyst | | 2 2.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Peritoneum | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 99
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
__________________________________________________________________________________________________________________________________
| 7| 1| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 5| 7| |
DAY ON TEST | 3| 7| 1| 3| 8| 3| 3| 1| 3| 3| 3| 2| 3| 3| 3| 3| 9| 3| 3| 3| 3| 4| 3| 9| 3| |
| 2| 0| 0| 3| 0| 3| 1| 9| 3| 2| 1| 5| 1| 1| 3| 3| 0| 3| 2| 3| 1| 8| 2| 3| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
.312% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 |
Granuloma Sperm | 2 2 2 2| 6 2.0|
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 |
Hyperplasia | 2 | 2 2.5|
Inflammation, Chronic Active | 2 3 2 2 2 2 2 2 2 2 2 1 2 2 2 1 2 1 2 2 2 2 2| 47 1.9|
Duct, Ectasia | 4 2 2 2 2 | 7 2.3|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 |
Cyst | | 1 2.0|
Inflammation, Chronic Active | 2 2 1 2 2 2 2 2 2 4 | 20 1.8|
Mineralization | 2 | 1 2.0|
Epithelium, Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 |
Mineralization | 1 1 2 2 1 1 2 1 1 1 1 1 2 1 1 1 1 1 1 1 2 2| 44 1.2|
Interstitial Cell, Hyperplasia | 1 | 4 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 4 4 4 3 4 3 4 4 4| 21 3.6|
Myeloid Cell, Hyperplasia | | 1 4.0|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + +| 28 |
Ectasia | 4 | 1 4.0|
Bronchial, Ectasia | | 1 2.0|
Bronchial, Hyperplasia, Lymphoid | | 1 2.0|
Deep Cervical, Ectasia | 2 2 2 | 4 2.0|
Deep Cervical, Hyperplasia, Lymphoid | 2 2 2 | 4 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 100
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
__________________________________________________________________________________________________________________________________
| 7| 1| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 5| 7| |
DAY ON TEST | 3| 7| 1| 3| 8| 3| 3| 1| 3| 3| 3| 2| 3| 3| 3| 3| 9| 3| 3| 3| 3| 4| 3| 9| 3| |
| 2| 0| 0| 3| 0| 3| 1| 9| 3| 2| 1| 5| 1| 1| 3| 3| 0| 3| 2| 3| 1| 8| 2| 3| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
.312% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Mediastinal, Ectasia | 2 3 2 3 2 2 | 11 2.3|
Mediastinal, Hyperplasia, Lymphoid | 2 2 3 2 2 2 | 10 2.2|
Mediastinal, Pigmentation | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M M M M M M M M M M + M M M M M M M M + M M M| 4 |
Ectasia | | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 4 | 2 3.5|
Fibrosis | 2 3 | 3 2.3|
Hematopoietic Cell Proliferation | 2 2 2 2 | 10 2.1|
Hyperplasia, Lymphoid | 3 | 2 3.0|
Infarct | 2 | 1 2.0|
Lymphoid Follicle, Depletion Cellular| 3 | 1 3.0|
|__________________________________________________________________________|____________|
Thymus | + + + + M + + + + + + + + + + + + + + + + M + M +| 45 |
Ectopic Parathyroid Gland | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Cystic | 1 2 2 2 1 2 2 1 2 2 1 2 2 1 1 1 3 2 1 2 | 41 1.5|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis | 4 | 1 4.0|
Inflammation, Granulomatous | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Osteopetrosis | | 1 3.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 101
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
__________________________________________________________________________________________________________________________________
| 7| 1| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 5| 7| |
DAY ON TEST | 3| 7| 1| 3| 8| 3| 3| 1| 3| 3| 3| 2| 3| 3| 3| 3| 9| 3| 3| 3| 3| 4| 3| 9| 3| |
| 2| 0| 0| 3| 0| 3| 1| 9| 3| 2| 1| 5| 1| 1| 3| 3| 0| 3| 2| 3| 1| 8| 2| 3| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
.312% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM - cont | | |
Skeletal Muscle | + + | 3 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 2 | 2 2.0|
Hemorrhage | 3 2 | 4 2.5|
Hydrocephalus | 2 2 | 3 2.3|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 | 1 3.0|
Inflammation, Chronic Active | 1 1 2 1 1 1 1 2 1 2 1 2 1 1 1 | 31 1.2|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 47 1.0|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 32 1.0|
Thrombosis | | 1 2.0|
Alveolar Epithelium, Hyperplasia | 2 2 2 2| 10 1.9|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 32 1.1|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X | 1 |
Inflammation, Chronic Active | 2 2 | 2 2.0|
Thrombosis | 1 2 | 3 2.3|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 3 3 | 4 2.5|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + | 2 |
Cornea, Inflammation, Chronic Active | | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 102
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
__________________________________________________________________________________________________________________________________
| 7| 1| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 5| 7| |
DAY ON TEST | 3| 7| 1| 3| 8| 3| 3| 1| 3| 3| 3| 2| 3| 3| 3| 3| 9| 3| 3| 3| 3| 4| 3| 9| 3| |
| 2| 0| 0| 3| 0| 3| 1| 9| 3| 2| 1| 5| 1| 1| 3| 3| 0| 3| 2| 3| 1| 8| 2| 3| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
.312% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
Cornea, Inflammation, Suppurative | 4 | 1 4.0|
Lens, Cataract | | 1 3.0|
|__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accumulation, Hyaline Droplet | | 1 3.0|
Infarct | 4 | 1 4.0|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 30 1.0|
Nephropathy | 2 1 2 1 2 2 2 3 2 2 2 2 2 2 2 1 1 2 1 1 1 1 2 2| 49 1.7|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 |
Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 103
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
_____________________________________________________________________________________________________________________
| 6| 6| 5| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| 5| 7| 7| 7| 4| 7| 7|
DAY ON TEST | 2| 5| 0| 3| 2| 3| 2| 3| 3| 3| 3| 3| 7| 3| 3| 9| 3| 3| 7| 3| 3| 3| 8| 3| 3|
| 1| 5| 6| 2| 4| 1| 7| 2| 2| 1| 3| 1| 7| 2| 3| 5| 5| 2| 7| 3| 2| 1| 8| 1| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
.625% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X X X |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X X X X X X X X X X X|
Eosinophilic Focus | X|
Hematopoietic Cell Proliferation | 1 2 |
Hepatodiaphragmatic Nodule | X X X |
Inflammation, Chronic Active | 2 2 2 2 2 1 2 2 1 2 1 2 2 2 1 2 1|
Mixed Cell Focus | X X X X X X X X X X X X |
Necrosis | 2 |
Bile Duct, Hyperplasia | 2 1 2 2 3 2 2 1 3 2 1 2 2 3 2 2 2 1 2 1 1 1 2|
Hepatocyte, Degeneration, Cystic | 1 1 1 2|
Hepatocyte, Hyperplasia | 3 |
Hepatocyte, Vacuolization Cytoplasmic| 2 1 1 1 3 1 1 1 1 2 2 1 2 2 2 1 1 1 1 1|
|__________________________________________________________________________|
Mesentery | + + + |
Fat, Inflammation, Chronic | 3 3 |
Fat, Mineralization | 2 2 |
Fat, Necrosis | 4 4 4 |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + + +|
Foreign Body | X X X X X X X|
__________________________________________|__________________________________________________________________________|
Page 104
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
_____________________________________________________________________________________________________________________
| 6| 6| 5| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| 5| 7| 7| 7| 4| 7| 7|
DAY ON TEST | 2| 5| 0| 3| 2| 3| 2| 3| 3| 3| 3| 3| 7| 3| 3| 9| 3| 3| 7| 3| 3| 3| 8| 3| 3|
| 1| 5| 6| 2| 4| 1| 7| 2| 2| 1| 3| 1| 7| 2| 3| 5| 5| 2| 7| 3| 2| 1| 8| 1| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
.625% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Gingival, Inflammation, Chronic | |
Active | 2 2 2 2 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 4 1 2 2 1 2 2 1 3 4 1 1|
Acinus, Hyperplasia | |
Artery, Inflammation, Chronic Active | 2 |
Duct, Cyst | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 2 |
Basophilic Focus | X X X X X X X X |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Epithelium, Hyperkeratosis | 2 |
Epithelium, Hyperplasia | 2 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Ectasia | 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1|
|__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Mineralization | 1 1 |
Atrium, Thrombosis | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 |
Angiectasis | |
Hematopoietic Cell Proliferation | 1 |
__________________________________________|__________________________________________________________________________|
Page 105
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
_____________________________________________________________________________________________________________________
| 6| 6| 5| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| 5| 7| 7| 7| 4| 7| 7|
DAY ON TEST | 2| 5| 0| 3| 2| 3| 2| 3| 3| 3| 3| 3| 7| 3| 3| 9| 3| 3| 7| 3| 3| 3| 8| 3| 3|
| 1| 5| 6| 2| 4| 1| 7| 2| 2| 1| 3| 1| 7| 2| 3| 5| 5| 2| 7| 3| 2| 1| 8| 1| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
.625% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Hyperplasia | 2 1 2 2 2 2 1|
Hypertrophy | 2 |
Mineralization | |
Necrosis | 2 |
Vacuolization Cytoplasmic | 1 3 1 1 2 3 1 1 2 1 1 1 1 1 1 2 1 1 1|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 3 3 1 2 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + M + M|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 1 2 |
Pars Distalis, Hyperplasia | 2 1 1 2 2 1 2 1 2 2 2|
Pars Intermedia, Cyst | 2 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | 2 |
C-Cell, Hyperplasia | 1 1 1 2 1 1 1 |
Follicle, Cyst | 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Coagulating Gland | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 2|
Inflammation, Chronic Active | 2 1|
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
Inflammation, Chronic Active | 2 2 1 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Duct, Ectasia | 2 2 4 2 2 |
__________________________________________|__________________________________________________________________________|
Page 106
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
_____________________________________________________________________________________________________________________
| 6| 6| 5| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| 5| 7| 7| 7| 4| 7| 7|
DAY ON TEST | 2| 5| 0| 3| 2| 3| 2| 3| 3| 3| 3| 3| 7| 3| 3| 9| 3| 3| 7| 3| 3| 3| 8| 3| 3|
| 1| 5| 6| 2| 4| 1| 7| 2| 2| 1| 3| 1| 7| 2| 3| 5| 5| 2| 7| 3| 2| 1| 8| 1| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
.625% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + M + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Chronic Active | 4 2 2 2 1 2 2 2 2 2 2|
Mineralization | |
Epithelium, Hyperplasia | 1 2 2 2 2 |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + M + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 1 1 1 1 1 1 2 1 1 1 2 2 1 1 1 1 1|
Germinal Epithelium, Atrophy | 4 2 2 |
Interstitial Cell, Hyperplasia | 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 4 3 4 4 4 3 4 3 4 3|
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + +|
Deep Cervical, Ectasia | 2 2 |
Deep Cervical, Hyperplasia, Lymphoid | 2 3|
Mediastinal, Ectasia | 3 3 2 2 2 |
Mediastinal, Hyperplasia, Lymphoid | 3 2 2 3 2 2 2 3 |
|__________________________________________________________________________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 1 2 3 |
Hyperplasia, Lymphoid | 4 |
Infarct | |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + M + + + + + + + + + + + + + +|
Ectopic Parathyroid Gland | 2 2 |
__________________________________________|__________________________________________________________________________|
Page 107
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
_____________________________________________________________________________________________________________________
| 6| 6| 5| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| 5| 7| 7| 7| 4| 7| 7|
DAY ON TEST | 2| 5| 0| 3| 2| 3| 2| 3| 3| 3| 3| 3| 7| 3| 3| 9| 3| 3| 7| 3| 3| 3| 8| 3| 3|
| 1| 5| 6| 2| 4| 1| 7| 2| 2| 1| 3| 1| 7| 2| 3| 5| 5| 2| 7| 3| 2| 1| 8| 1| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
.625% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 1 2 2 2 1 1 2 1 1 2 1 3 2 2 1 2 2 3 1 2 2 1 1|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Inflammation, Chronic Active | |
Dermis, Fibrosis | |
Epidermis, Hyperplasia | |
Hair Follicle, Sebaceous Gland, | |
Atrophy | |
Subcutaneous Tissue, Mineralization | 3|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 4 2 |
Hemorrhage | |
Hydrocephalus | 2 2 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Inflammation, Chronic Active | 2 1 1 1 1 1 1 2 1 2 1 1 1 1 1|
Metaplasia, Osseous | |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Alveolar Epithelium, Hyperplasia | 1 2 1 4 2|
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 108
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
_____________________________________________________________________________________________________________________
| 6| 6| 5| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| 5| 7| 7| 7| 4| 7| 7|
DAY ON TEST | 2| 5| 0| 3| 2| 3| 2| 3| 3| 3| 3| 3| 7| 3| 3| 9| 3| 3| 7| 3| 3| 3| 8| 3| 3|
| 1| 5| 6| 2| 4| 1| 7| 2| 2| 1| 3| 1| 7| 2| 3| 5| 5| 2| 7| 3| 2| 1| 8| 1| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
.625% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X X X|
Inflammation, Chronic Active | 2 2|
Thrombosis | 4 3 4 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 1 2 2 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + |
Lens, Cataract | 4 |
Retina, Degeneration | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 2 |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Nephropathy | 2 2 2 2 1 1 1 2 1 2 2 3 2 1 2 2 1 3 2 2 1 2 2|
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 109
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
__________________________________________________________________________________________________________________________________
| 6| 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| 7| 1| 7| 5| 1| 7| 6| 7| 6| 6| |
DAY ON TEST | 2| 6| 9| 3| 3| 1| 8| 3| 3| 3| 3| 3| 1| 3| 3| 3| 7| 3| 8| 2| 3| 0| 3| 7| 4| |
| 4| 0| 3| 2| 3| 3| 2| 2| 1| 1| 1| 1| 4| 2| 5| 1| 8| 3| 3| 3| 3| 9| 3| 6| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
.625% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X | 1 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X X | 8 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 1 2.0|
Basophilic Focus | X X X X X X X X X | 23 |
Eosinophilic Focus | X | 2 |
Hematopoietic Cell Proliferation | | 2 1.5|
Hepatodiaphragmatic Nodule | X X | 5 |
Inflammation, Chronic Active | 1 1 1 2 2 1 2 2 1 1 2 2 1 1 | 31 1.6|
Mixed Cell Focus | X X X X X X X X | 20 |
Necrosis | 2 1 | 3 1.7|
Bile Duct, Hyperplasia | 2 1 2 1 3 1 1 2 3 3 2 2 2 2 2 2 2 2 1 2| 43 1.9|
Hepatocyte, Degeneration, Cystic | | 4 1.3|
Hepatocyte, Hyperplasia | 2 | 2 2.5|
Hepatocyte, Vacuolization Cytoplasmic| 2 3 1 1 2 1 1 1 3 1 1 3 | 32 1.5|
|__________________________________________________________________________|____________|
Mesentery | + + + + + + | 9 |
Fat, Inflammation, Chronic | 4 3 3 3 | 6 3.2|
Fat, Mineralization | 1 1 2 | 5 1.6|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 110
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
__________________________________________________________________________________________________________________________________
| 6| 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| 7| 1| 7| 5| 1| 7| 6| 7| 6| 6| |
DAY ON TEST | 2| 6| 9| 3| 3| 1| 8| 3| 3| 3| 3| 3| 1| 3| 3| 3| 7| 3| 8| 2| 3| 0| 3| 7| 4| |
| 4| 0| 3| 2| 3| 3| 2| 2| 1| 1| 1| 1| 4| 2| 5| 1| 8| 3| 3| 3| 3| 9| 3| 6| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
.625% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Fat, Necrosis | 4 4 4 4 4 | 8 4.0|
|__________________________________________________________________________|____________|
Oral Mucosa | + + + + | 12 |
Foreign Body | X X X | 10 |
Gingival, Inflammation, Chronic | | |
Active | 2 3 | 6 2.2|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 1 2 1 1 2 1 1 2 4 2 | 23 1.9|
Acinus, Hyperplasia | 3 | 1 3.0|
Artery, Inflammation, Chronic Active | | 1 2.0|
Duct, Cyst | 2 1 2 | 3 1.7|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 1 1 | 6 1.5|
Basophilic Focus | X X X X X X X X X X| 18 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 2.0|
Epithelium, Hyperkeratosis | 2 2 | 3 2.0|
Epithelium, Hyperplasia | 3 2 | 3 2.3|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Glands, Ectasia | 1 1 1 1 1 1 1 1 1 | 27 1.0|
|__________________________________________________________________________|____________|
Tongue | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3| 45 2.0|
Mineralization | | 2 1.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 111
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
__________________________________________________________________________________________________________________________________
| 6| 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| 7| 1| 7| 5| 1| 7| 6| 7| 6| 6| |
DAY ON TEST | 2| 6| 9| 3| 3| 1| 8| 3| 3| 3| 3| 3| 1| 3| 3| 3| 7| 3| 8| 2| 3| 0| 3| 7| 4| |
| 4| 0| 3| 2| 3| 3| 2| 2| 1| 1| 1| 1| 4| 2| 5| 1| 8| 3| 3| 3| 3| 9| 3| 6| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
.625% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM - cont | | |
Atrium, Thrombosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | | 1 1.0|
Angiectasis | 2| 1 2.0|
Hematopoietic Cell Proliferation | 1 | 2 1.0|
Hyperplasia | 2 2 2 2 2 1 1 | 14 1.7|
Hypertrophy | | 1 2.0|
Mineralization | 2 | 1 2.0|
Necrosis | 2 1 | 3 1.7|
Vacuolization Cytoplasmic | 3 2 3 2 1 1 1 2 1 3 1 1 1 1| 33 1.5|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 3 | 8 2.4|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + M + + + + + + + + + + + M + + + +| 46 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Cyst | 1 | 3 1.3|
Pars Distalis, Hyperplasia | 1 1 1 2 2 2 2 | 18 1.6|
Pars Intermedia, Cyst | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ultimobranchial Cyst | 2 | 2 2.0|
C-Cell, Hyperplasia | 1 1 1 1 1 1 1 1 | 15 1.1|
Follicle, Cyst | | 2 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 112
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
__________________________________________________________________________________________________________________________________
| 6| 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| 7| 1| 7| 5| 1| 7| 6| 7| 6| 6| |
DAY ON TEST | 2| 6| 9| 3| 3| 1| 8| 3| 3| 3| 3| 3| 1| 3| 3| 3| 7| 3| 8| 2| 3| 0| 3| 7| 4| |
| 4| 0| 3| 2| 3| 3| 2| 2| 1| 1| 1| 1| 4| 2| 5| 1| 8| 3| 3| 3| 3| 9| 3| 6| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
.625% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Coagulating Gland | + | 1 |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma Sperm | 2 2 2 | 4 2.0|
Inflammation, Chronic Active | | 2 1.5|
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 2 2.0|
Inflammation, Chronic Active | 1 1 2 2 4 2 2 1 2 2 2 2 2 2 2 2 1 3 2 2| 43 1.9|
Duct, Ectasia | 2 | 6 2.3|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 2 | 1 2.0|
Inflammation, Chronic Active | 2 2 2 2 1 1 1 2 1 | 20 1.9|
Mineralization | 2 | 1 2.0|
Epithelium, Hyperplasia | 2 2 2 | 8 1.9|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 2 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 36 1.1|
Germinal Epithelium, Atrophy | | 3 2.7|
Interstitial Cell, Hyperplasia | 1 1 | 7 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 4 3 4 3 4 3 4 4 3 4 4 4 4 4| 26 3.7|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + +| 28 |
Deep Cervical, Ectasia | 2 2 | 4 2.0|
Deep Cervical, Hyperplasia, Lymphoid | 2 3 | 4 2.5|
Mediastinal, Ectasia | 3 3 2 2 2 2 | 11 2.4|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 113
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
__________________________________________________________________________________________________________________________________
| 6| 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| 7| 1| 7| 5| 1| 7| 6| 7| 6| 6| |
DAY ON TEST | 2| 6| 9| 3| 3| 1| 8| 3| 3| 3| 3| 3| 1| 3| 3| 3| 7| 3| 8| 2| 3| 0| 3| 7| 4| |
| 4| 0| 3| 2| 3| 3| 2| 2| 1| 1| 1| 1| 4| 2| 5| 1| 8| 3| 3| 3| 3| 9| 3| 6| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
.625% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Mediastinal, Hyperplasia, Lymphoid | 3 2 2 2 | 12 2.3|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M M M M M| |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 |
Ectasia | | 1 3.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | | 4 2.0|
Hyperplasia, Lymphoid | | 1 4.0|
Infarct | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Thymus | + + M + + + + + + + + M + + + + + + + + + + + M +| 46 |
Ectopic Parathyroid Gland | | 2 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Cystic | 4 2 2 2 1 3 1 1 2 1 2 2 2 2 1 1 1 1 1 1 1 2| 45 1.6|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis | 2 | 1 2.0|
Inflammation, Chronic Active | 2 | 1 2.0|
Dermis, Fibrosis | 4 | 1 4.0|
Epidermis, Hyperplasia | 2 | 1 2.0|
Hair Follicle, Sebaceous Gland, | | |
Atrophy | 4 | 1 4.0|
Subcutaneous Tissue, Mineralization | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 114
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
__________________________________________________________________________________________________________________________________
| 6| 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| 7| 1| 7| 5| 1| 7| 6| 7| 6| 6| |
DAY ON TEST | 2| 6| 9| 3| 3| 1| 8| 3| 3| 3| 3| 3| 1| 3| 3| 3| 7| 3| 8| 2| 3| 0| 3| 7| 4| |
| 4| 0| 3| 2| 3| 3| 2| 2| 1| 1| 1| 1| 4| 2| 5| 1| 8| 3| 3| 3| 3| 9| 3| 6| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
.625% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 3 | 3 3.0|
Hemorrhage | 4 2 | 2 3.0|
Hydrocephalus | 2 3 | 5 2.4|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 3.0|
Inflammation, Chronic Active | 2 1 1 1 1 1 1 1 1 3 1 1 | 27 1.2|
Metaplasia, Osseous | 2 | 1 2.0|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 48 1.0|
Pigmentation | 1 1 1 1 1 1 1 1 | 23 1.0|
Alveolar Epithelium, Hyperplasia | 2 1 2 2 | 9 1.9|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 1 1 1 1 1 1 1 1 | 24 1.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X | 4 |
Inflammation, Chronic Active | 1 | 3 1.7|
Thrombosis | 4 2 4 | 6 3.5|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 1 2 | 5 1.6|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | | 1 |
Lens, Cataract | | 1 4.0|
Retina, Degeneration | | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 115
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
__________________________________________________________________________________________________________________________________
| 6| 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| 7| 1| 7| 5| 1| 7| 6| 7| 6| 6| |
DAY ON TEST | 2| 6| 9| 3| 3| 1| 8| 3| 3| 3| 3| 3| 1| 3| 3| 3| 7| 3| 8| 2| 3| 0| 3| 7| 4| |
| 4| 0| 3| 2| 3| 3| 2| 2| 1| 1| 1| 1| 4| 2| 5| 1| 8| 3| 3| 3| 3| 9| 3| 6| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
.625% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct | 4 | 2 3.0|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 32 1.0|
Nephropathy | 1 2 2 2 1 2 1 2 2 1 2 1 2 2 1 2 2 1 2 2 1| 44 1.7|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 116
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 0| 9| 3| 3| 3| 3| 9| 3| 3| 6| 3|
| 1| 3| 2| 2| 1| 2| 3| 3| 3| 1| 3| 2| 5| 3| 9| 8| 2| 2| 1| 2| 9| 1| 1| 6| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.25% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X |
Hepatodiaphragmatic Nodule | X |
Inflammation, Chronic Active | 2 2 2 1 2 1 2 1 2 1 1 2 1 2 2 1 2 2 2 1|
Mixed Cell Focus | X X X X X X X X X X X X X X X X|
Necrosis | 2 |
Bile Duct, Hyperplasia | 2 2 2 2 2 2 2 2 2 1 2 1 2 1 1 2 2 2 2 2 2 2|
Hepatocyte, Degeneration, Cystic | 1 1 1 |
Hepatocyte, Hyperplasia | |
Hepatocyte, Hypertrophy | |
Hepatocyte, Vacuolization Cytoplasmic| 1 1 1 1 1 1 1 2 1 2 1 1 1 1 2 1 2|
|__________________________________________________________________________|
Mesentery | + + + + + |
Fat, Inflammation, Chronic | 3 2 3 |
Fat, Mineralization | 2 |
Fat, Necrosis | 4 4 4 |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + + + + |
Foreign Body | X X X X X X X |
Gingival, Inflammation, Chronic | |
__________________________________________|__________________________________________________________________________|
Page 117
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 0| 9| 3| 3| 3| 3| 9| 3| 3| 6| 3|
| 1| 3| 2| 2| 1| 2| 3| 3| 3| 1| 3| 2| 5| 3| 9| 8| 2| 2| 1| 2| 9| 1| 1| 6| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.25% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Active | 2 2 2 1 3 1 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Acinus, Atrophy | 1 2 2 3 1|
Duct, Cyst | 2 2 2 2 2|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Basophilic Focus | X X X X 1 X X X X X X|
Inflammation, Chronic Active | |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Mineralization | 2 |
Epithelium, Erosion | 3 |
Epithelium, Ulcer | 4 |
Glands, Ectasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Mineralization | 2 |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 2 2 2 2 2 2 2 1 1 2 2 1 2 1 2 1 2 2 2 2|
Mineralization | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 2 |
Hematopoietic Cell Proliferation | 1 1 1 |
Hyperplasia | 2 2 2 2 4 1 1 2 1 |
Hypertrophy | 1 |
__________________________________________|__________________________________________________________________________|
Page 118
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 0| 9| 3| 3| 3| 3| 9| 3| 3| 6| 3|
| 1| 3| 2| 2| 1| 2| 3| 3| 3| 1| 3| 2| 5| 3| 9| 8| 2| 2| 1| 2| 9| 1| 1| 6| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.25% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Necrosis | 2 |
Vacuolization Cytoplasmic | 2 1 1 1 2 2 2 1 3 1 2 3 1 4 1 1 2|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + M + + + + + + M M|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Cyst | 2 1 |
Pars Distalis, Hyperplasia | 2 1 1 2 1 2 2 1 1 1 2 |
Pars Intermedia, Angiectasis | 3 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | 2 |
C-Cell, Hyperplasia | 2 1 2 1 1 1 2 1 2 1 2 1 1|
Follicle, Cyst | 2 2 |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Peritoneum | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 2 2 2 |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 2 |
Inflammation, Chronic Active | 2 2 1 2 2 2 2 2 2 2 2 2 1 2 2 2 2 1 2 2 2 2 1 2|
Mineralization | 1 |
Duct, Ectasia | 3 2 2 |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 119
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 0| 9| 3| 3| 3| 3| 9| 3| 3| 6| 3|
| 1| 3| 2| 2| 1| 2| 3| 3| 3| 1| 3| 2| 5| 3| 9| 8| 2| 2| 1| 2| 9| 1| 1| 6| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.25% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Cyst | 3 |
Inflammation, Chronic Active | 1 2 1 1 1 4 2 1 |
Epithelium, Hyperplasia | 1 2 |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
Mineralization | 1 1 1 1 1 1 1 2 1 2 1 1 1 1 1 1 1 2 1|
Germinal Epithelium, Atrophy | 3 |
Interstitial Cell, Hyperplasia | 1 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 4 4 4 3 4 3 3 3 3 3 |
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + |
Deep Cervical, Ectasia | 3 |
Deep Cervical, Hyperplasia, Lymphoid | 2 |
Mediastinal, Ectasia | 2 2 2 2 |
Mediastinal, Hyperplasia, Lymphoid | 2 2 2 2 3 2 3 2 |
|__________________________________________________________________________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 2 |
Hyperplasia, Lymphoid | 3 2 3 2 |
|__________________________________________________________________________|
Thymus | + + + + + + M + + + + + + + + + + + + + M M + M +|
Ectopic Parathyroid Gland | 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 120
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 0| 9| 3| 3| 3| 3| 9| 3| 3| 6| 3|
| 1| 3| 2| 2| 1| 2| 3| 3| 3| 1| 3| 2| 5| 3| 9| 8| 2| 2| 1| 2| 9| 1| 1| 6| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.25% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
Hyperplasia, Cystic | 1 1 2 2 2 2 2 1 1 1 1 1 2 2 1 2 2 2 1 2 2 2|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Hemorrhage | |
Hydrocephalus | 2 |
Thrombosis | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 1 |
Inflammation, Chronic Active | 1 2 2 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Alveolar Epithelium, Hyperplasia | 2 3 2 2 2 2 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X X X |
Inflammation, Chronic Active | 3 2 1 3 |
Polyp Inflammatory | |
Thrombosis | 4 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 2 2 2 2 2 2 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 121
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 0| 9| 3| 3| 3| 3| 9| 3| 3| 6| 3|
| 1| 3| 2| 2| 1| 2| 3| 3| 3| 1| 3| 2| 5| 3| 9| 8| 2| 2| 1| 2| 9| 1| 1| 6| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.25% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Zymbal's Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Cyst | 2 |
Inflammation, Suppurative | 2 |
Metaplasia, Osseous | 3 |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1|
Necrosis | 3 |
Nephropathy | 2 1 2 2 2 2 2 1 2 2 2 2 4 2 2 2 1 1 3 2 1 2|
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 122
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 9| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| |
| 2| 2| 1| 1| 3| 3| 5| 2| 1| 3| 2| 1| 1| 2| 3| 1| 2| 3| 2| 2| 1| 1| 3| 2| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
1.25% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X | 1 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X X X | 4 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X | 33 |
Clear Cell Focus | | 3 |
Hepatodiaphragmatic Nodule | X X X | 4 |
Inflammation, Chronic Active | 1 1 2 1 2 2 1 2 1 1 1 2 1 2 2 2 1 1 2| 39 1.5|
Mixed Cell Focus | X X X X X X X X X X X X X X X X| 32 |
Necrosis | 2 1 2 1| 5 1.6|
Bile Duct, Hyperplasia | 2 2 1 2 2 2 1 2 1 2 2 1 1 2 1 1 2 2 2 1 1| 43 1.7|
Hepatocyte, Degeneration, Cystic | 1 1 | 5 1.0|
Hepatocyte, Hyperplasia | 4 | 1 4.0|
Hepatocyte, Hypertrophy | 2 | 1 2.0|
Hepatocyte, Vacuolization Cytoplasmic| 1 1 1 1 1 1 1 1 1 1 1 3 1 1 1 1 2| 34 1.2|
|__________________________________________________________________________|____________|
Mesentery | + + + + + + + | 12 |
Fat, Inflammation, Chronic | 3 3 3 3 2 3 | 9 2.8|
Fat, Mineralization | 1 1 2 2 1 | 6 1.5|
Fat, Necrosis | 4 4 4 4 4 4 4 | 10 4.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 123
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 9| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| |
| 2| 2| 1| 1| 3| 3| 5| 2| 1| 3| 2| 1| 1| 2| 3| 1| 2| 3| 2| 2| 1| 1| 3| 2| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
1.25% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Oral Mucosa | + + + + + + + + + + + + + + + | 24 |
Foreign Body | X X X X X X X X X X X X X X X | 22 |
Gingival, Inflammation, Chronic | | |
Active | 1 2 2 2 1 1 | 12 1.7|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 2.0|
Acinus, Atrophy | 1 1 3 2 3 2 2 2 2 2 4| 16 2.1|
Duct, Cyst | 3 3 2 3 2 | 10 2.3|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 2.0|
Basophilic Focus | X X X X X X X X X X X X X | 24 1.0|
Inflammation, Chronic Active | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 2.0|
Mineralization | | 1 2.0|
Epithelium, Erosion | | 1 3.0|
Epithelium, Ulcer | | 1 4.0|
Glands, Ectasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 39 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Aorta, Mineralization | | 1 2.0|
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 1 2 1 2 1 2 1 1 2 2| 50 1.8|
Mineralization | | 1 1.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 124
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 9| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| |
| 2| 2| 1| 1| 3| 3| 5| 2| 1| 3| 2| 1| 1| 2| 3| 1| 2| 3| 2| 2| 1| 1| 3| 2| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
1.25% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | | 2 2.0|
Hematopoietic Cell Proliferation | 1 1 1 1| 7 1.0|
Hyperplasia | 1 2 2 1| 13 1.8|
Hypertrophy | 1 | 2 1.0|
Necrosis | | 1 2.0|
Vacuolization Cytoplasmic | 1 2 1 3 1 2 1| 24 1.7|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 3 2 1 | 5 2.2|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M M + + + + + + M + + M + + + M + + + + +| 42 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | | 1 2.0|
Pars Distalis, Cyst | 2 2 | 4 1.8|
Pars Distalis, Hyperplasia | 2 3 3 2 3 1 2 2 3 2 | 21 1.9|
Pars Intermedia, Angiectasis | | 1 3.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ultimobranchial Cyst | 2 | 2 2.0|
C-Cell, Hyperplasia | 2 1 1 1 3 2 2 3 2 2 | 23 1.6|
Follicle, Cyst | 3 | 3 2.3|
Follicular Cell, Hyperplasia | 1 | 2 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Peritoneum | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 125
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 9| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| |
| 2| 2| 1| 1| 3| 3| 5| 2| 1| 3| 2| 1| 1| 2| 3| 1| 2| 3| 2| 2| 1| 1| 3| 2| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
1.25% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma Sperm | 2 2 | 5 2.0|
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 3 2.3|
Inflammation, Chronic Active | 2 2 2 2 2 2 2 2 2 1 2 2 2 2 1 1 2 2 2 2 2 2 2 2 2| 49 1.9|
Mineralization | | 1 1.0|
Duct, Ectasia | 3 2 3 2 2 2 | 9 2.3|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 3.0|
Inflammation, Chronic Active | 2 2 2 2 1 1 1| 15 1.6|
Epithelium, Hyperplasia | 2 2 2 2| 6 1.8|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 3.0|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 2 1| 41 1.1|
Germinal Epithelium, Atrophy | 3 | 2 3.0|
Interstitial Cell, Hyperplasia | | 3 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 4 3 4 3 4 3 4 3 4 3 3 | 22 3.5|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 20 |
Deep Cervical, Ectasia | 2 | 2 2.5|
Deep Cervical, Hyperplasia, Lymphoid | 2 2 | 3 2.0|
Mediastinal, Ectasia | 2 2 2 | 7 2.0|
Mediastinal, Hyperplasia, Lymphoid | 2 2 2 3 | 12 2.3|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M M M M M| |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 126
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 9| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| |
| 2| 2| 1| 1| 3| 3| 5| 2| 1| 3| 2| 1| 1| 2| 3| 1| 2| 3| 2| 2| 1| 1| 3| 2| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
1.25% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | | 1 2.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 2 2 2| 6 2.3|
Hyperplasia, Lymphoid | 2 | 5 2.4|
|__________________________________________________________________________|____________|
Thymus | + M + + + + + + + + + + + + + + + M M + + + + + +| 43 |
Ectopic Parathyroid Gland | 2 | 2 1.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Cystic | 1 2 2 4 2 1 1 1 2 1 2 1 1 1 2 2 1 2 1 2 1 1 2 1 1| 47 1.6|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 2 | 1 2.0|
Hemorrhage | 2 | 1 2.0|
Hydrocephalus | 2 | 2 2.0|
Thrombosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 127
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 9| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| |
| 2| 2| 1| 1| 3| 3| 5| 2| 1| 3| 2| 1| 1| 2| 3| 1| 2| 3| 2| 2| 1| 1| 3| 2| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
1.25% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | | 2 1.5|
Inflammation, Chronic Active | 1 1 2 1 1 1 1 1 2 2 1 1 1 2 1 1 1 | 36 1.2|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 49 1.0|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 35 1.0|
Alveolar Epithelium, Hyperplasia | 2 2 1 1 | 11 1.8|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 35 1.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | | 3 |
Inflammation, Chronic Active | | 4 2.3|
Polyp Inflammatory | 3 | 1 3.0|
Thrombosis | 4 | 2 4.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 1 | 9 1.9|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Zymbal's Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 4.0|
Cyst | | 1 2.0|
Inflammation, Suppurative | | 1 2.0|
Metaplasia, Osseous | | 1 3.0|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 38 1.0|
Necrosis | | 1 3.0|
Nephropathy | 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 45 1.9|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 128
NTP Experiment-Test: 56111-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 06/01/01
Route: DOSED FEED Time: 10:41:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 9| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| |
| 2| 2| 1| 1| 3| 3| 5| 2| 1| 3| 2| 1| 1| 2| 3| 1| 2| 3| 2| 2| 1| 1| 3| 2| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
1.25% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 129
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---------- END OF REPORT ----------
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