TDMS Study 61427-08 Pathology Tables
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
FINAL#2/MICE
Facility: Battelle Northwest
Chemical CAS #: 1314-62-1
Lock Date: 11/02/99
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 9| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3|
| 3| 3| 1| 3| 2| 3| 3| 1| 3| 2| 5| 3| 1| 2| 3| 2| 2| 3| 2| 1| 1| 6| 2| 2| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + + + + + M + + + + + + + + + + + A + + +|
Inflammation, Suppurative | |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + A + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + A + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + A + + +|
Inflammation, Suppurative | 1 |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + A + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + A + + +|
Inflammation, Suppurative | |
Ulcer | |
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | |
Eosinophilic Focus | X X X X X X |
Eosinophilic Focus, Multiple | X |
Hematopoietic Cell Proliferation | 2 2 2 |
Inflammation, Focal, Granulomatous | 1 1 1 1 1 1 1 |
Necrosis, Focal | 2 |
Pigmentation, Hemosiderin | |
Tension Lipidosis | X X |
Bile Duct, Cyst | 2 |
Centrilobular, Necrosis | 1 |
|__________________________________________________________________________|
Mesentery | + + + + + + + + |
Hemorrhage | |
Artery, Inflammation | |
Fat, Inflammation | 2 |
Fat, Necrosis | 3 3 3 2 4 3 4 |
__________________________________________|__________________________________________________________________________|
Page 2
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 9| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3|
| 3| 3| 1| 3| 2| 3| 3| 1| 3| 2| 5| 3| 1| 2| 3| 2| 2| 3| 2| 1| 1| 6| 2| 2| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 1 |
Epithelium, Hyperplasia | 1 2 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1|
Mineralization | |
Artery, Inflammation | |
Capillary, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypertrophy | 1 1 1 1 |
Capsule, Hyperplasia | 3 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + M + + M + + + + + + + + + + + + + + + + + M +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 1 2 |
Pars Distalis, Hyperplasia | 2 1 2 4 1 4 1 2 2 1 2 1|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 3
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 9| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3|
| 3| 3| 1| 3| 2| 3| 3| 1| 3| 2| 5| 3| 1| 2| 3| 2| 2| 3| 2| 1| 1| 6| 2| 2| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + M + + + + + + + M + + M M + + + + + + M + + +|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + M + + + + + + + + + + +|
Angiectasis | 2 |
Cyst | 2 2 2 1 3 1 |
Thrombosis | |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 4 3 2 |
Hyperplasia, Cystic | 3 3 2 4 3 4 4 2 4 1 1 2 1 4 2 4 2 3 4 2 2 4 2 |
Inflammation, Focal | |
Inflammation | |
Myometrium, Hyperplasia | 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 |
|__________________________________________________________________________|
Lymph Node | + |
Angiectasis | 3 |
|__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + M + + + + M + + +|
Hyperplasia | 2 2 2 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + M + M +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + M + M M +|
Hyperplasia | 2 |
__________________________________________|__________________________________________________________________________|
Page 4
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 9| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3|
| 3| 3| 1| 3| 2| 3| 3| 1| 3| 2| 5| 3| 1| 2| 3| 2| 2| 3| 2| 1| 1| 6| 2| 2| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
|__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + M + + + M + + + + + + M + + M|
Hyperplasia | 2 3 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 2 3 1 3 2 2 1 |
Hyperplasia, Lymphoid | 2 2 2 3 1 1 2 2 2 2 |
|__________________________________________________________________________|
Thymus | + + M + + + + + + + + + + + + M + + + + + + + + +|
Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 1 2 1 2 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | |
Necrosis | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Squamous Epithelium, Hyperplasia | 1 1 1 1 1 1 |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 5
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 9| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3|
| 3| 3| 1| 3| 2| 3| 3| 1| 3| 2| 5| 3| 1| 2| 3| 2| 2| 3| 2| 1| 1| 6| 2| 2| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Hemorrhage | 2 1 |
Inflammation, Chronic | 1 1 1 |
Metaplasia, Osseous | 4 |
Mineralization | |
Thrombosis | 1 |
Perivascular, Infiltration Cellular | 1 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 1 1 1 1 1 1 |
Lateral Wall, Metaplasia, Squamous | |
Olfactory Epithelium, Atrophy | |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 1 2 1 1 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 2 1 1 2 2 1 1 1 2 1 2 1 1 1 1 |
Respiratory Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Harderian Gland | |
Inflammation, Focal, Granulomatous | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accumulation, Hyaline Droplet | 4 |
Cyst | 2 |
Glomerulosclerosis | |
Metaplasia, Osseous | 1 |
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1|
Pigmentation, Hemosiderin | 2 |
Artery, Inflammation | |
Renal Tubule, Pigmentation, | |
Hemosiderin | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + I + + +|
__________________________________________|__________________________________________________________________________
Page 6
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 5| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 0| 3| 8| 3| 1| 3| 3| 3| 6| 3| 3| 8| 2| 3| 0| 3| 3| 4| |
| 2| 2| 3| 1| 2| 3| 2| 9| 1| 1| 3| 5| 2| 3| 2| 2| 3| 3| 6| 6| 3| 5| 2| 3| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + A + + + + + + + + + + + + + + M| 46 |
Inflammation, Suppurative | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + M + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + + + + + + + A| 47 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + A + + + + + + + + + + + + + + A| 47 |
Inflammation, Suppurative | | 1 1.0|
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + + + + + + + + A| 47 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + + + + + + + A| 47 |
Inflammation, Suppurative | 3 | 1 3.0|
Ulcer | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Clear Cell Focus | X | 1 |
Eosinophilic Focus | X X X X X X | 12 |
Eosinophilic Focus, Multiple | X X X | 4 |
Hematopoietic Cell Proliferation | 1 | 4 1.8|
Inflammation, Focal, Granulomatous | 1 1 1 1 1 | 12 1.0|
Necrosis, Focal | 1 | 2 1.5|
Pigmentation, Hemosiderin | 2 | 1 2.0|
Tension Lipidosis | | 2 |
Bile Duct, Cyst | | 1 2.0|
Centrilobular, Necrosis | | 1 1.0|
|__________________________________________________________________________|____________|
Mesentery | + + + + + +| 14 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 5| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 0| 3| 8| 3| 1| 3| 3| 3| 6| 3| 3| 8| 2| 3| 0| 3| 3| 4| |
| 2| 2| 3| 1| 2| 3| 2| 9| 1| 1| 3| 5| 2| 3| 2| 2| 3| 3| 6| 6| 3| 5| 2| 3| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Hemorrhage | 4| 1 4.0|
Artery, Inflammation | 2 | 1 2.0|
Fat, Inflammation | | 1 2.0|
Fat, Necrosis | 3 3 2 2 | 11 2.9|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 4 | 3 2.3|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | | 1 1.0|
Epithelium, Hyperplasia | 3 | 3 2.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 |
Ulcer | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1| 47 1.1|
Mineralization | 2 1 | 2 1.5|
Artery, Inflammation | 1 | 1 1.0|
Capillary, Hyperplasia | | 2 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hypertrophy | 1 | 5 1.0|
Capsule, Hyperplasia | | 1 3.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + M + + +| 49 |
Hyperplasia | 1 1 | 4 1.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 5| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 0| 3| 8| 3| 1| 3| 3| 3| 6| 3| 3| 8| 2| 3| 0| 3| 3| 4| |
| 2| 2| 3| 1| 2| 3| 2| 9| 1| 1| 3| 5| 2| 3| 2| 2| 3| 3| 6| 6| 3| 5| 2| 3| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + + + + + I + + M M + M + + + + + + +| 42 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Cyst | | 2 1.5|
Pars Distalis, Hyperplasia | 2 1 4 1 3 2 1 3 1 2 | 22 2.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + M + + + + M + M + + + + + + + + + + + M M + M +| 39 |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + M + + + + +| 48 |
Angiectasis | | 1 2.0|
Cyst | 1 3 1 1 2 1 1 4 1 1 | 16 1.7|
Thrombosis | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 5 3.0|
Hyperplasia, Cystic | 4 4 4 4 3 3 3 1 3 4 3 2 2 3 4 3 3 2 3 2 4 2 1| 46 2.8|
Inflammation, Focal | 2 | 1 2.0|
Inflammation | 2 | 1 2.0|
Myometrium, Hyperplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 5| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 0| 3| 8| 3| 1| 3| 3| 3| 6| 3| 3| 8| 2| 3| 0| 3| 3| 4| |
| 2| 2| 3| 1| 2| 3| 2| 9| 1| 1| 3| 5| 2| 3| 2| 2| 3| 3| 6| 6| 3| 5| 2| 3| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Hyperplasia | 2 | 5 2.0|
|__________________________________________________________________________|____________|
Lymph Node | + + | 3 |
Angiectasis | 3 3 | 3 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M + + + + + + + + + M M M + + M + + M M M M + +| 39 |
Hyperplasia | | 3 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M + + + M + + + + + + + + + + + M + M + + + M M| 41 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + M + + + + + + + + + + + + + + + + + + + + +| 46 |
Hyperplasia | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + M + + + + + M M + + + + + + + + + + + + + +| 43 |
Hyperplasia | 2 2 2 2 | 6 2.2|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 2 3 2 2 3 3 2 2 4 2 1 2 2 | 21 2.2|
Hyperplasia, Lymphoid | 2 2 2 2 2 2 2 | 17 1.9|
|__________________________________________________________________________|____________|
Thymus | + + + M + + + + + M + I + + + + + + M + + + + + +| 44 |
Hyperplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 | 3 2.0|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | | 1 3.0|
Inflammation, Suppurative | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 5| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 0| 3| 8| 3| 1| 3| 3| 3| 6| 3| 3| 8| 2| 3| 0| 3| 3| 4| |
| 2| 2| 3| 1| 2| 3| 2| 9| 1| 1| 3| 5| 2| 3| 2| 2| 3| 3| 6| 6| 3| 5| 2| 3| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM - cont | | |
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 1 1 1 2 1 1 1 1 1 1 2 1 2 2 | 28 1.2|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrocephalus | 2 | 1 2.0|
Necrosis | 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 1 1 | 3 1.0|
Squamous Epithelium, Hyperplasia | 1 1 1 1 1 1 1 1 2 | 15 1.1|
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 1 | 4 1.3|
Inflammation, Chronic | 1 | 4 1.0|
Metaplasia, Osseous | | 1 4.0|
Mineralization | 2 | 1 2.0|
Thrombosis | | 1 1.0|
Perivascular, Infiltration Cellular | 2 | 2 1.5|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 1 1 1 1 1 1 2 1 1 1 1 | 19 1.1|
Lateral Wall, Metaplasia, Squamous | 1 | 1 1.0|
Olfactory Epithelium, Atrophy | 1 2 | 2 1.5|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 1 1 1 1 2 | 11 1.2|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 1 1 2 2 1 1 2 1 1 1 1 2 1 1 1 1 1 1 1 2| 35 1.3|
Respiratory Epithelium, Hyperplasia | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 5| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 0| 3| 8| 3| 1| 3| 3| 3| 6| 3| 3| 8| 2| 3| 0| 3| 3| 4| |
| 2| 2| 3| 1| 2| 3| 2| 9| 1| 1| 3| 5| 2| 3| 2| 2| 3| 3| 6| 6| 3| 5| 2| 3| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Harderian Gland | + + + | 3 |
Inflammation, Focal, Granulomatous | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accumulation, Hyaline Droplet | 4 | 2 4.0|
Cyst | | 1 2.0|
Glomerulosclerosis | 4 | 1 4.0|
Metaplasia, Osseous | 2 1 | 3 1.3|
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 2 1 1 1 | 43 1.1|
Pigmentation, Hemosiderin | | 1 2.0|
Artery, Inflammation | 2 | 1 2.0|
Renal Tubule, Pigmentation, | | |
Hemosiderin | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + M| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
_____________________________________________________________________________________________________________________
| 7| 6| 7| 0| 0| 7| 0| 6| 7| 4| 7| 5| 6| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 3| 6| 3| 2| 2| 3| 2| 0| 3| 4| 3| 3| 6| 6| 3| 3| 3| 0| 3| 3| 6| 3| 3| 3| 1|
| 2| 8| 3| 3| 3| 3| 3| 3| 3| 6| 1| 0| 0| 4| 2| 2| 2| 5| 3| 2| 0| 2| 5| 3| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + M + A A + A + + + + + A + M M + + + + A + + + +|
Inflammation, Suppurative | 1 |
|__________________________________________________________________________|
Intestine Large, Colon | + + + A A + A + + + + + + + + + + + + + A + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + A + + A + A + + + + + + + + + + + + + A + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + A + A A + A + + + + + + + + + + + + + A + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + A + A A + A + + + + + A + + + + + + + A + + + +|
Inflammation, Suppurative | 2 |
Ulcer | 2 |
|__________________________________________________________________________|
Intestine Small, Jejunum | + A + A A + A + + + + + A + + + + + + + A + + + +|
Inflammation | 3 |
|__________________________________________________________________________|
Intestine Small, Ileum | + A + A A + A + + + + + A + + + + + + + A + + + +|
Inflammation, Suppurative | 2 |
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Eosinophilic Focus | X X X X X X |
Eosinophilic Focus, Multiple | X |
Fatty Change | 4 |
Infiltration Cellular, Mixed Cell | 3 |
Inflammation, Focal, Granulomatous | 1 1 1 1 1 2 1 1 1 1 1 |
Necrosis, Focal | 2 1 1 1 |
Tension Lipidosis | X X|
Bile Duct, Cyst | |
Centrilobular, Degeneration | 3 |
Centrilobular, Inflammation, Chronic | |
|__________________________________________________________________________|
Mesentery | + + + + +|
Fat, Inflammation | |
Fat, Necrosis | 4 2 3 4 2|
__________________________________________|__________________________________________________________________________|
Page 13
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
_____________________________________________________________________________________________________________________
| 7| 6| 7| 0| 0| 7| 0| 6| 7| 4| 7| 5| 6| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 3| 6| 3| 2| 2| 3| 2| 0| 3| 4| 3| 3| 6| 6| 3| 3| 3| 0| 3| 3| 6| 3| 3| 3| 1|
| 2| 8| 3| 3| 3| 3| 3| 3| 3| 6| 1| 0| 0| 4| 2| 2| 2| 5| 3| 2| 0| 2| 5| 3| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 1 |
Epithelium, Hyperplasia | 1 |
|__________________________________________________________________________|
Stomach, Glandular | + A + + + + A + + + + + + + + + + + + + A + + + +|
Inflammation, Suppurative | |
Mineralization | |
Ulcer | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 2 1 1 1 1|
Mineralization | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypertrophy | 1 1 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + M M M + + + M + + M + + + M|
Cyst | 2 |
Hyperplasia | 3 |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 2 2 1 2 2 1 1 1 2 2 1 |
__________________________________________|__________________________________________________________________________|
Page 14
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
_____________________________________________________________________________________________________________________
| 7| 6| 7| 0| 0| 7| 0| 6| 7| 4| 7| 5| 6| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 3| 6| 3| 2| 2| 3| 2| 0| 3| 4| 3| 3| 6| 6| 3| 3| 3| 0| 3| 3| 6| 3| 3| 3| 1|
| 2| 8| 3| 3| 3| 3| 3| 3| 3| 6| 1| 0| 0| 4| 2| 2| 2| 5| 3| 2| 0| 2| 5| 3| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + M + + + + + M + M + + + + + + + + + + + +|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | 2 4 2 3 4 4 2|
Hemorrhage | 4 |
Thrombosis | 4 |
|__________________________________________________________________________|
Uterus | + + + + A + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Hyperplasia, Cystic | 3 3 3 2 1 1 3 3 4 2 4 2 2 2 2 3 1 2 1 |
Thrombosis | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
|__________________________________________________________________________|
Lymph Node | |
Angiectasis | |
|__________________________________________________________________________|
Lymph Node, Bronchial | + + + M + M M + M M + + + + + + M + + + + + + M +|
Hyperplasia | 1 2 2 1 3 3 2 |
|__________________________________________________________________________|
Lymph Node, Mandibular | M + + + M + + + + M + + M + + + + + M + + + + + +|
Hyperplasia | 4 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + A M + M + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________|__________________________________________________________________________|
Page 15
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
_____________________________________________________________________________________________________________________
| 7| 6| 7| 0| 0| 7| 0| 6| 7| 4| 7| 5| 6| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 3| 6| 3| 2| 2| 3| 2| 0| 3| 4| 3| 3| 6| 6| 3| 3| 3| 0| 3| 3| 6| 3| 3| 3| 1|
| 2| 8| 3| 3| 3| 3| 3| 3| 3| 6| 1| 0| 0| 4| 2| 2| 2| 5| 3| 2| 0| 2| 5| 3| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
|__________________________________________________________________________|
Lymph Node, Mediastinal | + + + M M + M M + M M + + + + + + + M + + + M + +|
Hyperplasia | 3 |
|__________________________________________________________________________|
Spleen | + + + M + + A + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 1 2 |
Hyperplasia, Lymphoid | 2 2 2 2 2 2 2 2 2 2|
|__________________________________________________________________________|
Thymus | + + + A + + M + + + + + + + + + + + + M + + + + +|
Amyloid Deposition | |
Angiectasis | 2 |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 4 |
Epidermis, Hyperplasia | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 1 1 1 1 2 1 2 1 1 1 1 |
|__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | 2 |
Meninges, Infiltration Cellular, | |
Mononuclear Cell | 2 |
Meninges, Inflammation | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 16
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
_____________________________________________________________________________________________________________________
| 7| 6| 7| 0| 0| 7| 0| 6| 7| 4| 7| 5| 6| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 3| 6| 3| 2| 2| 3| 2| 0| 3| 4| 3| 3| 6| 6| 3| 3| 3| 0| 3| 3| 6| 3| 3| 3| 1|
| 2| 8| 3| 3| 3| 3| 3| 3| 3| 6| 1| 0| 0| 4| 2| 2| 2| 5| 3| 2| 0| 2| 5| 3| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 1|
Respiratory Epithelium, Epiglottis, | |
Metaplasia, Squamous | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Squamous Epithelium, Hyperplasia | 1 1 1 1 1 1 2|
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Hemorrhage | |
Infiltration Cellular, Mast Cell | |
Inflammation, Chronic, Focal | 2 |
Inflammation, Chronic | 1 1 1 2 1 2 1 2 2 2 1 1 2 1 1 2 2 1 1|
Alveolar Epithelium, Hyperplasia | 2 1 2 1 1 1 2 2 1 1 2 2 3 2 1 1|
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 2 3 3 4 3 1 2 4 3 4 3 2 2 1 4|
Bronchiole, Epithelium, Hyperplasia | 1 1 1 1 1 1 1 1 |
Interstitium, Fibrosis | |
Perivascular, Infiltration Cellular | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 2 1 1 1 2 2 |
Lateral Wall, Metaplasia, Squamous | |
Olfactory Epithelium, Atrophy | 2 1 1 2 1 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 1 1 1 2 1 1 1 1 1 1 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 1 2 2 2 2 2 1 2 1 1 1 2 2 2 2 2|
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 1 |
|__________________________________________________________________________|
Pleura | +|
Mesothelium, Hyperplasia | 4|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + A + + + +|
Inflammation, Suppurative | 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 17
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
_____________________________________________________________________________________________________________________
| 7| 6| 7| 0| 0| 7| 0| 6| 7| 4| 7| 5| 6| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 3| 6| 3| 2| 2| 3| 2| 0| 3| 4| 3| 3| 6| 6| 3| 3| 3| 0| 3| 3| 6| 3| 3| 3| 1|
| 2| 8| 3| 3| 3| 3| 3| 3| 3| 6| 1| 0| 0| 4| 2| 2| 2| 5| 3| 2| 0| 2| 5| 3| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accumulation, Hyaline Droplet | 2 |
Cyst | 1 |
Infiltration Cellular, Mononuclear | |
Cell | 2 |
Metaplasia, Osseous | 1 1 |
Nephropathy | 1 1 1 1 2 1 1 1 1 1 1 1 1 1|
|__________________________________________________________________________|
Urinary Bladder | + + + A A + A + + + + + + + + + + + + + A + + + +|
__________________________________________|__________________________________________________________________________
Page 18
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 8| 3| 3| 3| 3| 3| 2| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 2| 3| 3| 3| 3| |
| 1| 4| 2| 2| 2| 1| 2| 2| 2| 4| 2| 3| 1| 1| 2| 1| 1| 3| 0| 1| 6| 2| 2| 3| 3| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
1.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + A + + + + + +| 41 |
Inflammation, Suppurative | | 1 1.0|
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + A + + + + + +| 45 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + A + + + + + +| 44 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + A + + + + + +| 43 |
Inflammation, Suppurative | | 1 2.0|
Ulcer | | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + A + + + + + +| 43 |
Inflammation | | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + A + + + + + +| 43 |
Inflammation, Suppurative | | 1 2.0|
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 | 1 1.0|
Eosinophilic Focus | X X X X X X | 12 |
Eosinophilic Focus, Multiple | X | 2 |
Fatty Change | | 1 4.0|
Infiltration Cellular, Mixed Cell | | 1 3.0|
Inflammation, Focal, Granulomatous | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 26 1.0|
Necrosis, Focal | 1 1 | 6 1.2|
Tension Lipidosis | X X | 4 |
Bile Duct, Cyst | 1 | 1 1.0|
Centrilobular, Degeneration | | 1 3.0|
Centrilobular, Inflammation, Chronic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 8| 3| 3| 3| 3| 3| 2| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 2| 3| 3| 3| 3| |
| 1| 4| 2| 2| 2| 1| 2| 2| 2| 4| 2| 3| 1| 1| 2| 1| 1| 3| 0| 1| 6| 2| 2| 3| 3| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
1.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Mesentery | + + + +| 9 |
Fat, Inflammation | 3 | 1 3.0|
Fat, Necrosis | 2 2 2 2| 9 2.6|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 4 2 1 | 4 2.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Amyloid Deposition | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | | 1 1.0|
Epithelium, Hyperplasia | | 1 1.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Inflammation, Suppurative | 2 | 1 2.0|
Mineralization | 1 | 1 1.0|
Ulcer | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 2 2 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 2 1 1 1 1| 45 1.1|
Mineralization | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hypertrophy | 2 1 1 | 5 1.2|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 8| 3| 3| 3| 3| 3| 2| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 2| 3| 3| 3| 3| |
| 1| 4| 2| 2| 2| 1| 2| 2| 2| 4| 2| 3| 1| 1| 2| 1| 1| 3| 0| 1| 6| 2| 2| 3| 3| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
1.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Hyperplasia | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + M + + + + + + + + + + M + + + + + +| 41 |
Cyst | | 1 2.0|
Hyperplasia | 2 | 2 2.5|
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Hyperplasia | 4 1 1 3 1 1 2 1 1 1 1 2 1 1 1 | 26 1.5|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Hyperplasia | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | I + + + + M + + + M + + M + + + + + + + + M + + +| 42 |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 1 2.0|
Cyst | 1 2 2 2 1 2 2 2 3 | 16 2.4|
Hemorrhage | | 1 4.0|
Thrombosis | | 1 4.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 2 3 2| 4 2.5|
Hyperplasia, Cystic | 4 1 3 1 2 2 2 1 2 2 4 1 1 1 3 2 3 4 1 2 3 2 1 1| 43 2.2|
Thrombosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 8| 3| 3| 3| 3| 3| 2| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 2| 3| 3| 3| 3| |
| 1| 4| 2| 2| 2| 1| 2| 2| 2| 4| 2| 3| 1| 1| 2| 1| 1| 3| 0| 1| 6| 2| 2| 3| 3| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
1.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Lymph Node | + | 1 |
Angiectasis | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + + + + + + + + M + + M + + + + + + + + + + +| 40 |
Hyperplasia | 2 2 2 1 2 1 | 13 1.8|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + M M + + M + + + + M + + + + M + + + + + +| 40 |
Hyperplasia | 2 | 2 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + M + + + M + + + + + I + M + + + + M + + + + +| 37 |
Hyperplasia | 2 2 2 | 4 2.3|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 2 2| 12 2.1|
Hyperplasia, Lymphoid | 2 2 2 2 2 4 2 2 | 18 2.1|
|__________________________________________________________________________|____________|
Thymus | + + + M + + + + + + + M + + + + + + + + + + + + +| 45 |
Amyloid Deposition | 3 | 1 3.0|
Angiectasis | | 1 2.0|
Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 4 | 2 4.0|
Epidermis, Hyperplasia | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 8| 3| 3| 3| 3| 3| 2| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 2| 3| 3| 3| 3| |
| 1| 4| 2| 2| 2| 1| 2| 2| 2| 4| 2| 3| 1| 1| 2| 1| 1| 3| 0| 1| 6| 2| 2| 3| 3| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
1.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 2 1 1 1 1 1 2 1 1 1 | 21 1.2|
|__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrocephalus | | 1 2.0|
Meninges, Infiltration Cellular, | | |
Mononuclear Cell | 2 | 2 2.0|
Meninges, Inflammation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 2 1.0|
Respiratory Epithelium, Epiglottis, | | |
Metaplasia, Squamous | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 39 1.0|
Squamous Epithelium, Hyperplasia | 1 1 1| 10 1.1|
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Amyloid Deposition | 2 | 1 2.0|
Hemorrhage | 1 1 1 | 3 1.0|
Infiltration Cellular, Mast Cell | 3 | 1 3.0|
Inflammation, Chronic, Focal | | 1 2.0|
Inflammation, Chronic | 1 1 2 1 1 1 1 1 1 1 1 1 1 2 1 1 1 2 | 37 1.3|
Alveolar Epithelium, Hyperplasia | 2 1 2 2 1 2 1 1 2 2 2 1 2 1 2 | 31 1.6|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 3 1 2 3 1 3 1 2 1 2 2 2 4 4 2 3 2 | 34 2.4|
Bronchiole, Epithelium, Hyperplasia | 1 1 1 1 | 12 1.0|
Interstitium, Fibrosis | 2 | 1 2.0|
Perivascular, Infiltration Cellular | 3 2 | 2 2.5|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 8| 3| 3| 3| 3| 3| 2| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 2| 3| 3| 3| 3| |
| 1| 4| 2| 2| 2| 1| 2| 2| 2| 4| 2| 3| 1| 1| 2| 1| 1| 3| 0| 1| 6| 2| 2| 3| 3| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
1.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 1 1 1 1 1 1 | 14 1.2|
Lateral Wall, Metaplasia, Squamous | 2 | 1 2.0|
Olfactory Epithelium, Atrophy | 1 1 1 | 8 1.3|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 1 1 1 1 1 1 1 1 1 1 1| 23 1.0|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 1 1 1 1 2 1 1 1 2 2 2 2 1 1 2 1 1 2 2 1 2 1| 39 1.5|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 2 | 3 1.3|
|__________________________________________________________________________|____________|
Pleura | | 1 |
Mesothelium, Hyperplasia | | 1 4.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accumulation, Hyaline Droplet | | 1 2.0|
Cyst | | 1 1.0|
Infiltration Cellular, Mononuclear | | |
Cell | | 1 2.0|
Metaplasia, Osseous | 1 | 3 1.0|
Nephropathy | 1 1 1 1 1 4 1 1 1 1 1 1 1 1 1 1 1 1 1 | 33 1.1|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + A + + + + + +| 45 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 3| 5| 7| 4| 3| 6| 7| 7| 7| 2| 6| 7| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 3| 3| 0| 2| 1| 3| 3| 1| 5| 6| 3| 3| 0| 5| 9| 3| 3| 3| 0| 3| 3| 3| 8|
| 1| 1| 3| 9| 9| 5| 8| 4| 1| 6| 3| 6| 3| 2| 9| 1| 5| 1| 2| 2| 5| 2| 1| 3| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
2.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + M + + + + + + + + + + + A + + + + + + + + I|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + A + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + A + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + A + + + + + + + + +|
Epithelium, Hyperplasia | 2 |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + A + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 |
Eosinophilic Focus | X X |
Eosinophilic Focus, Multiple | |
Hematopoietic Cell Proliferation | 1 3 |
Inflammation, Focal, Granulomatous | 2 1 1 1 1 1 1 1 1 1|
Necrosis, Focal | 1 1 2 2 |
Pigmentation, Hemosiderin | 2 |
Tension Lipidosis | X |
Centrilobular, Necrosis | 3 |
|__________________________________________________________________________|
Mesentery | + + + +|
Fat, Inflammation | |
Fat, Necrosis | 2 2 1 2|
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 25
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 3| 5| 7| 4| 3| 6| 7| 7| 7| 2| 6| 7| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 3| 3| 0| 2| 1| 3| 3| 1| 5| 6| 3| 3| 0| 5| 9| 3| 3| 3| 0| 3| 3| 3| 8|
| 1| 1| 3| 9| 9| 5| 8| 4| 1| 6| 3| 6| 3| 2| 9| 1| 5| 1| 2| 2| 5| 2| 1| 3| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
2.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 |
Ulcer | 2 1 |
Epithelium, Hyperplasia | 1 1 2 4 4 2 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 2 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 2|
Inflammation | |
Mineralization | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 1 |
Hypertrophy | 1 1 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + M|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + M + + + + + + + M + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 1 |
Pars Distalis, Hyperplasia | 1 2 2 2 2 1 1 4 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Cyst | 2 |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
__________________________________________|__________________________________________________________________________|
Page 26
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 3| 5| 7| 4| 3| 6| 7| 7| 7| 2| 6| 7| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 3| 3| 0| 2| 1| 3| 3| 1| 5| 6| 3| 3| 0| 5| 9| 3| 3| 3| 0| 3| 3| 3| 8|
| 1| 1| 3| 9| 9| 5| 8| 4| 1| 6| 3| 6| 3| 2| 9| 1| 5| 1| 2| 2| 5| 2| 1| 3| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
2.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | M + M + M + + + + + + M + + + + + + + + M M + + +|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | 2 3 1 2 4 1 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Hyperplasia, Cystic | 2 3 3 1 1 1 3 1 2 2 1 2 3 1 2 3 4 4 3 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2|
|__________________________________________________________________________|
Lymph Node | + + + |
|__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + M + + + + + + + + + M + + + + + + + + I|
Hyperplasia | 2 2 2 2 2 2 3 2 3 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + M + M + M + + + + + + M +|
Hyperplasia | |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Lymph Node, Mediastinal | M + + M + + M M + + + + M + M + M + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 3 2 2 3 2 3 2 2 2 |
Hyperplasia, Lymphoid | 2 2 4 2 2 2 2 2 2|
|__________________________________________________________________________|
Thymus | + + + + + M + + + + + + + + + M + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 27
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 3| 5| 7| 4| 3| 6| 7| 7| 7| 2| 6| 7| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 3| 3| 0| 2| 1| 3| 3| 1| 5| 6| 3| 3| 0| 5| 9| 3| 3| 3| 0| 3| 3| 3| 8|
| 1| 1| 3| 9| 9| 5| 8| 4| 1| 6| 3| 6| 3| 2| 9| 1| 5| 1| 2| 2| 5| 2| 1| 3| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
2.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Inflammation, | |
Chronic | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 3 1 3 1 1 1 1 2 2 2 1 1|
Fracture | X X X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Necrosis | 1 1 |
Meninges, Inflammation | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 1 |
Respiratory Epithelium, Epiglottis, | |
Metaplasia, Squamous | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Squamous Epithelium, Hyperplasia | 2 1 2 1 2 1 2 2 1|
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 2 |
Inflammation, Chronic | 2 2 2 4 2 1 2 2 2 2 2 1 1 1 2 2 2 2 2 1 2|
Alveolar Epithelium, Hyperplasia | 2 2 1 3 2 1 2 1 1 2 1 2 2 2 1 3 2 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 4 2 2 4 2 2 1 2 3 2 1 3 2 4 1 2 1 2|
Bronchiole, Epithelium, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2|
Interstitium, Fibrosis | 4 2 |
Perivascular, Infiltration Cellular | 2 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 28
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 3| 5| 7| 4| 3| 6| 7| 7| 7| 2| 6| 7| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 3| 3| 0| 2| 1| 3| 3| 1| 5| 6| 3| 3| 0| 5| 9| 3| 3| 3| 0| 3| 3| 3| 8|
| 1| 1| 3| 9| 9| 5| 8| 4| 1| 6| 3| 6| 3| 2| 9| 1| 5| 1| 2| 2| 5| 2| 1| 3| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
2.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 4 2 |
Inflammation, Suppurative | 1 1 1 1 2 1 1 1 1 1 2 1 1 1 1 1 1|
Lateral Wall, Hyperplasia | 2|
Lateral Wall, Metaplasia, Squamous | 2 2 2 |
Olfactory Epithelium, Atrophy | 1 1 1 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 1 2 1 1 2 1 1 1 1 2 1 1 1 2 1|
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 2 2 1 2 1 2 2 2 1 1 1 2 2 2 2 2 2 2 2 1 1 2 2|
Respiratory Epithelium, Hyperplasia | 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 1 2 1 |
Respiratory Epithelium, Necrosis | 2 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + |
Anterior Chamber, Cornea, | |
Inflammation | 4 |
|__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Osseous | |
Nephropathy | 1 1 1 2 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1|
Artery, Inflammation | 2|
Renal Tubule, Degeneration, Hyaline | 2 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 29
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 4| 7| 7| 7| 7| 5| 6| 7| 7| 7| 2| 7| 7| 7| 7| 2| 5| 7| 7| 7| 7| |
DAY ON TEST | 4| 3| 3| 3| 9| 3| 3| 3| 3| 0| 6| 3| 3| 3| 8| 3| 3| 3| 3| 7| 7| 3| 3| 3| 3| |
| 6| 3| 2| 3| 0| 2| 2| 3| 2| 1| 2| 2| 1| 3| 1| 3| 2| 3| 3| 0| 7| 3| 3| 3| 3| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
2.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + A + + + + A + + + + A + + + + A + + + + +| 43 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + A + + + + A + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + A + + + + A + + + + A + + + + +| 46 |
Epithelium, Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A + + + + A + + + + A + + + + A + + + + +| 45 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + A + + + + A + + + + A + + + + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 4.0|
Eosinophilic Focus | X | 3 |
Eosinophilic Focus, Multiple | X | 1 |
Hematopoietic Cell Proliferation | 2 2 1 3 | 6 2.0|
Inflammation, Focal, Granulomatous | 1 1 1 1 1 1 1 1 1 | 19 1.1|
Necrosis, Focal | 1 2 1 2 2 | 9 1.6|
Pigmentation, Hemosiderin | 2 | 2 2.0|
Tension Lipidosis | | 1 |
Centrilobular, Necrosis | | 1 3.0|
|__________________________________________________________________________|____________|
Mesentery | + | 5 |
Fat, Inflammation | 2 | 1 2.0|
Fat, Necrosis | 2 | 5 1.8|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 4| 7| 7| 7| 7| 5| 6| 7| 7| 7| 2| 7| 7| 7| 7| 2| 5| 7| 7| 7| 7| |
DAY ON TEST | 4| 3| 3| 3| 9| 3| 3| 3| 3| 0| 6| 3| 3| 3| 8| 3| 3| 3| 3| 7| 7| 3| 3| 3| 3| |
| 6| 3| 2| 3| 0| 2| 2| 3| 2| 1| 2| 2| 1| 3| 1| 3| 2| 3| 3| 0| 7| 3| 3| 3| 3| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
2.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Atrophy | 1 | 2 1.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 1 1.0|
Ulcer | | 2 1.5|
Epithelium, Hyperplasia | 2 | 7 2.3|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + A + + + + A + + + + +| 48 |
Ulcer | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 2 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 46 1.1|
Inflammation | 2 | 1 2.0|
Mineralization | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
Degeneration, Cystic | | 2 1.5|
Hypertrophy | 1 | 3 1.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Parathyroid Gland | M + + + M + + + + + M + + + M + + + + M + + + + +| 43 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Cyst | | 1 1.0|
Pars Distalis, Hyperplasia | 1 2 2 4 2 1 2 | 15 1.9|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 4| 7| 7| 7| 7| 5| 6| 7| 7| 7| 2| 7| 7| 7| 7| 2| 5| 7| 7| 7| 7| |
DAY ON TEST | 4| 3| 3| 3| 9| 3| 3| 3| 3| 0| 6| 3| 3| 3| 8| 3| 3| 3| 3| 7| 7| 3| 3| 3| 3| |
| 6| 3| 2| 3| 0| 2| 2| 3| 2| 1| 2| 2| 1| 3| 1| 3| 2| 3| 3| 0| 7| 3| 3| 3| 3| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
2.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + M + + + + M + + + + +| 48 |
Follicular Cell, Cyst | | 1 2.0|
Follicular Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | M M + + + M + + + + + M + + + M + + + + + + + + +| 39 |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
Angiectasis | 2 | 1 2.0|
Cyst | 2 2 4 1 3 2 2 1 2 | 15 2.1|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
Angiectasis | | 1 3.0|
Hyperplasia, Cystic | 3 1 3 1 2 3 2 2 2 3 3 3 2 4 2 1 2 1 1 4 2 1| 42 2.2|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 3 2 | 6 2.2|
|__________________________________________________________________________|____________|
Lymph Node | + + | 5 |
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + M + + + + + + + + + + M + + + + + + + +| 45 |
Hyperplasia | 2 2 3 2 3 | 14 2.3|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + M M + + M + + + + + M + M M + + + + + + +| 40 |
Hyperplasia | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + M + + + + A + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 4| 7| 7| 7| 7| 5| 6| 7| 7| 7| 2| 7| 7| 7| 7| 2| 5| 7| 7| 7| 7| |
DAY ON TEST | 4| 3| 3| 3| 9| 3| 3| 3| 3| 0| 6| 3| 3| 3| 8| 3| 3| 3| 3| 7| 7| 3| 3| 3| 3| |
| 6| 3| 2| 3| 0| 2| 2| 3| 2| 1| 2| 2| 1| 3| 1| 3| 2| 3| 3| 0| 7| 3| 3| 3| 3| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
2.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + A + + + + + + + + + +| 42 |
Hyperplasia | 4 2 2 2 3 | 5 2.6|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 2 2 1 4 4 2 2 3 | 18 2.4|
Hyperplasia, Lymphoid | 2 2 2 2 2 2| 15 2.1|
|__________________________________________________________________________|____________|
Thymus | + + + + + M + + + + + + + + M M + + + M + + + + +| 44 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 4 1.8|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcutaneous Tissue, Inflammation, | | |
Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 1 1 1 1 1 1 1 1 1 1 | 22 1.3|
Fracture | | 3 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 1 2.0|
Necrosis | | 2 1.0|
Meninges, Inflammation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 4| 7| 7| 7| 7| 5| 6| 7| 7| 7| 2| 7| 7| 7| 7| 2| 5| 7| 7| 7| 7| |
DAY ON TEST | 4| 3| 3| 3| 9| 3| 3| 3| 3| 0| 6| 3| 3| 3| 8| 3| 3| 3| 3| 7| 7| 3| 3| 3| 3| |
| 6| 3| 2| 3| 0| 2| 2| 3| 2| 1| 2| 2| 1| 3| 1| 3| 2| 3| 3| 0| 7| 3| 3| 3| 3| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
2.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 1 | 3 1.0|
Respiratory Epithelium, Epiglottis, | | |
Metaplasia, Squamous | 2 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1| 45 1.0|
Squamous Epithelium, Hyperplasia | 1 2 1 1 1 1 1 1 | 17 1.4|
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 2 | 4 1.8|
Inflammation, Chronic | 1 1 2 1 3 2 1 1 2 2 1 2 2 2 2 2 2 2| 39 1.8|
Alveolar Epithelium, Hyperplasia | 2 1 2 3 4 4 1 3 2 2 3 3 1 1 2 2 2 2 4 1| 38 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 3 1 4 4 4 2 4 1 3 3 3 2 2 2 3 1| 35 2.4|
Bronchiole, Epithelium, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 34 1.0|
Interstitium, Fibrosis | 2 2 | 4 2.5|
Perivascular, Infiltration Cellular | 4 2| 3 2.7|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | | 2 3.0|
Inflammation, Suppurative | 1 1 1 1 2 1 2 1 1 1 2 1 1 1 1| 32 1.2|
Lateral Wall, Hyperplasia | | 1 2.0|
Lateral Wall, Metaplasia, Squamous | 1 | 4 1.8|
Olfactory Epithelium, Atrophy | 1 1 | 5 1.0|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 2 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 | 34 1.2|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 3 2 1 1 2 1 2 2 2 2 2 2 2 1 1 2 2 2 1 2 2 2| 46 1.7|
Respiratory Epithelium, Hyperplasia | | 1 1.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 1 1 1 | 7 1.1|
Respiratory Epithelium, Necrosis | | 1 2.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + A + + + + A + + + + M + + + + +| 47 |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 4| 7| 7| 7| 7| 5| 6| 7| 7| 7| 2| 7| 7| 7| 7| 2| 5| 7| 7| 7| 7| |
DAY ON TEST | 4| 3| 3| 3| 9| 3| 3| 3| 3| 0| 6| 3| 3| 3| 8| 3| 3| 3| 3| 7| 7| 3| 3| 3| 3| |
| 6| 3| 2| 3| 0| 2| 2| 3| 2| 1| 2| 2| 1| 3| 1| 3| 2| 3| 3| 0| 7| 3| 3| 3| 3| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
2.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | | 1 |
Anterior Chamber, Cornea, | | |
Inflammation | | 1 4.0|
|__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
Metaplasia, Osseous | 1 | 1 1.0|
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 43 1.0|
Artery, Inflammation | | 1 2.0|
Renal Tubule, Degeneration, Hyaline | | 1 2.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 1| 3| 3| 3| 3| 3| 3| 3| 2| 9| 3| 3| 3| 3| 8| 3| 2| 0| 5| 3| 3| 3| 3| 3| 3|
| 1| 3| 3| 3| 3| 1| 2| 1| 8| 5| 2| 2| 3| 1| 7| 3| 6| 5| 0| 2| 9| 3| 2| 3| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
4.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + + + + A + + + + M + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + A + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + A + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Eosinophilic Focus | X X X X X |
Hematopoietic Cell Proliferation | 1 2|
Inflammation, Focal, Granulomatous | 1 1 1 1 1 1 1 1 1 1 |
Necrosis, Focal | 1 2 1 |
Tension Lipidosis | X X |
Bile Duct, Cyst | 3 |
|__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 3 2 |
|__________________________________________________________________________|
Oral Mucosa | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 |
Duct, Cyst | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 36
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 1| 3| 3| 3| 3| 3| 3| 3| 2| 9| 3| 3| 3| 3| 8| 3| 2| 0| 5| 3| 3| 3| 3| 3| 3|
| 1| 3| 3| 3| 3| 1| 2| 1| 8| 5| 2| 2| 3| 1| 7| 3| 6| 5| 0| 2| 9| 3| 2| 3| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
4.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Cyst | 2 |
Inflammation, Suppurative | |
Mineralization | 1 |
Ulcer | |
Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 |
Epithelium, Hyperplasia | 1 |
|__________________________________________________________________________|
Tooth | + |
Malformation | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 2 1 1 1 1 1 2 1 2 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 2 |
Hypertrophy | 1 1 1 1 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + M M M + + M + + + M + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + I + + I + + + + + +|
Pars Distalis, Cyst | 2 |
Pars Distalis, Hyperplasia | 1 2 2 1 1 1 1 2 2 1 2 1 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 1 |
Follicular Cell, Cyst | |
__________________________________________|__________________________________________________________________________|
Page 37
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 1| 3| 3| 3| 3| 3| 3| 3| 2| 9| 3| 3| 3| 3| 8| 3| 2| 0| 5| 3| 3| 3| 3| 3| 3|
| 1| 3| 3| 3| 3| 1| 2| 1| 8| 5| 2| 2| 3| 1| 7| 3| 6| 5| 0| 2| 9| 3| 2| 3| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
4.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Peritoneum | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | M + + + + M + + M + + M + + + + + M + + + + + + M|
|__________________________________________________________________________|
Ovary | + + + M + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | 2 1 2 3 1 2 2 3 1 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 4 2 2 4 3 2 4 3 4 2 2 2 4 2 3 2 4 2 4 1|
Serosa, Fibrosis | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2|
|__________________________________________________________________________|
Lymph Node | |
|__________________________________________________________________________|
Lymph Node, Bronchial | + + + M + + + + + M M + + M + + + + + + + + + + +|
Hyperplasia | 2 2 4 4 3 2 2 2 2 2|
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + + + + M + + + + + + + + + + M + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia | 2|
|__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + M + + + + + + + + + M + + M|
Hyperplasia | 2 3 4 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 38
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 1| 3| 3| 3| 3| 3| 3| 3| 2| 9| 3| 3| 3| 3| 8| 3| 2| 0| 5| 3| 3| 3| 3| 3| 3|
| 1| 3| 3| 3| 3| 1| 2| 1| 8| 5| 2| 2| 3| 1| 7| 3| 6| 5| 0| 2| 9| 3| 2| 3| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
4.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 4 2 4 2|
Hyperplasia, Lymphoid | 2 2 4 2 2 1 2 2|
|__________________________________________________________________________|
Thymus | + + + + + + + + + M + + + M + + + + + M M + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 1 2 1 1 2 2 1 1 3 1 1 2 1 1 1 3 1 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 |
Respiratory Epithelium, Epiglottis, | |
Metaplasia, Squamous | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1|
Squamous Epithelium, Hyperplasia | 1 1 1 1 2 1 1 |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 1 1 1|
Inflammation, Chronic | 2 2 3 2 2 3 3 1 2 1 3 2 2 2 2 1 2 2 2 3 4 1 2 2 2|
Alveolar Epithelium, Hyperplasia | 3 3 4 2 4 4 4 4 4 3 4 3 4 4 2 2 2 2 4 4 4 2 4 4 4|
Alveolus, Infiltration Cellular, | |
Histiocyte | 3 2 3 3 3 3 2 2 2 3 2 2 2 4 4 4 3 4 4 2 3 2 2|
Bronchiole, Epithelium, Hyperplasia | 2 1 2 2 1 1 2 2 1 1 2 1 2 1 1 1 2 1 1 1 1 2 1 1|
Interstitium, Fibrosis | 1 2 1 2 2 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 39
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 1| 3| 3| 3| 3| 3| 3| 3| 2| 9| 3| 3| 3| 3| 8| 3| 2| 0| 5| 3| 3| 3| 3| 3| 3|
| 1| 3| 3| 3| 3| 1| 2| 1| 8| 5| 2| 2| 3| 1| 7| 3| 6| 5| 0| 2| 9| 3| 2| 3| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
4.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Inflammation, Suppurative | 1 1 1 2 1 2 1 1 1 1 3 1 1 1 1|
Lateral Wall, Hyperplasia | |
Lateral Wall, Metaplasia, Squamous | |
Olfactory Epithelium, Atrophy | 1 1 1 1 2 1 1 1 2 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 1 1 1 1 1 1 1 2 1 2 1 1 2 1 2 2 1 1 1 1 1 1 1 2|
Respiratory Epithelium, Degeneration,| |
Hyaline | 2 2 1 2 2 2 2 2 2 2 2 1 2 2 1 2 2 1 2 2 2 1 2 2 2|
Respiratory Epithelium, Hyperplasia | |
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 1 1 1 |
Respiratory Epithelium, Necrosis | 1 1 2 1 |
|__________________________________________________________________________|
Pleura | |
Mesothelium, Hyperplasia | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Squamous | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accumulation, Hyaline Droplet | |
Cyst | 1 |
Metaplasia, Osseous | 1 1 |
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + I + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 40
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 6| 7| 7| 2| 5| 6| 7| 7| 7| 5| 7| 7| 7| 4| 7| |
DAY ON TEST | 3| 0| 3| 3| 2| 4| 5| 3| 3| 3| 1| 3| 3| 5| 6| 5| 3| 3| 3| 6| 3| 3| 3| 7| 3| |
| 3| 5| 2| 2| 5| 2| 0| 1| 2| 3| 2| 2| 2| 5| 5| 3| 2| 2| 3| 5| 2| 1| 1| 8| 3| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
4.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + M + + + + + + + + + + + M + + M + + + + +| 45 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + M + + + + + + + + M + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X | 1 |
Eosinophilic Focus | X X X | 8 |
Hematopoietic Cell Proliferation | 1 | 3 1.3|
Inflammation, Focal, Granulomatous | 1 1 1 1 1 1 2 1 1 1 1| 21 1.0|
Necrosis, Focal | 1 1 | 5 1.2|
Tension Lipidosis | | 2 |
Bile Duct, Cyst | | 1 3.0|
|__________________________________________________________________________|____________|
Mesentery | + + | 4 |
Fat, Necrosis | 3 | 3 2.7|
|__________________________________________________________________________|____________|
Oral Mucosa | + | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 3 | 4 1.5|
Duct, Cyst | 4 | 1 4.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 6| 7| 7| 2| 5| 6| 7| 7| 7| 5| 7| 7| 7| 4| 7| |
DAY ON TEST | 3| 0| 3| 3| 2| 4| 5| 3| 3| 3| 1| 3| 3| 5| 6| 5| 3| 3| 3| 6| 3| 3| 3| 7| 3| |
| 3| 5| 2| 2| 5| 2| 0| 1| 2| 3| 2| 2| 2| 5| 5| 3| 2| 2| 3| 5| 2| 1| 1| 8| 3| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
4.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 | 2 2.5|
Inflammation, Suppurative | 4 | 1 4.0|
Mineralization | | 1 1.0|
Ulcer | 1 | 1 1.0|
Epithelium, Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 1 1.0|
Epithelium, Hyperplasia | | 1 1.0|
|__________________________________________________________________________|____________|
Tooth | | 1 |
Malformation | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 2 1 2 1 1 1 1 1 1 2 1 1 1 1 1 1 1 2 1 1 1 1| 49 1.1|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 |
Degeneration, Cystic | | 2 2.0|
Hypertrophy | 1 1 1| 7 1.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + + + + + + I M M + + + + + + + M +| 39 |
Hyperplasia | 1 | 1 1.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 6| 7| 7| 2| 5| 6| 7| 7| 7| 5| 7| 7| 7| 4| 7| |
DAY ON TEST | 3| 0| 3| 3| 2| 4| 5| 3| 3| 3| 1| 3| 3| 5| 6| 5| 3| 3| 3| 6| 3| 3| 3| 7| 3| |
| 3| 5| 2| 2| 5| 2| 0| 1| 2| 3| 2| 2| 2| 5| 5| 3| 2| 2| 3| 5| 2| 1| 1| 8| 3| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
4.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + M + + + + + + + + + + + +| 47 |
Pars Distalis, Cyst | 1 | 2 1.5|
Pars Distalis, Hyperplasia | 4 2 1 2 1 1 2 1| 20 1.6|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 2 1.0|
Follicular Cell, Cyst | 3| 1 3.0|
Follicular Cell, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Peritoneum | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + M + + + + + + + M + + + M + + M + + + + + + + +| 40 |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + M + + + M + +| 47 |
Angiectasis | 1 | 1 1.0|
Cyst | 2 4 1 1 3 1 4 2| 17 2.1|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Cystic | 3 2 3 2 3 2 4 2 2 3 4 1 2 2 2 3 2 2 4 2 4| 41 2.7|
Serosa, Fibrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 1| 6 1.8|
|__________________________________________________________________________|____________|
Lymph Node | + | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + M M + + + + + + + + + + + + + + M + + M + M +| 41 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 6| 7| 7| 2| 5| 6| 7| 7| 7| 5| 7| 7| 7| 4| 7| |
DAY ON TEST | 3| 0| 3| 3| 2| 4| 5| 3| 3| 3| 1| 3| 3| 5| 6| 5| 3| 3| 3| 6| 3| 3| 3| 7| 3| |
| 3| 5| 2| 2| 5| 2| 0| 1| 2| 3| 2| 2| 2| 5| 5| 3| 2| 2| 3| 5| 2| 1| 1| 8| 3| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
4.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Hyperplasia | 2 2 2 2 1 3 4 2 1 2| 20 2.3|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + M + + +| 46 |
Hyperplasia | 2 2 3| 3 2.3|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 1 2.0|
Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + M + + + + + M + + + + M + + + + M + + + M +| 42 |
Hyperplasia | 3 1 3 | 6 2.7|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 2 2 2 3 2 2 | 11 2.5|
Hyperplasia, Lymphoid | 2 2 2 2 2 2 2| 15 2.1|
|__________________________________________________________________________|____________|
Thymus | + + M + M + + + + + + + + + + M + + + + + + M M +| 41 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 1 1 3 1 1 1 2 1 1 1 1 1 2 2| 32 1.5|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 6| 7| 7| 2| 5| 6| 7| 7| 7| 5| 7| 7| 7| 4| 7| |
DAY ON TEST | 3| 0| 3| 3| 2| 4| 5| 3| 3| 3| 1| 3| 3| 5| 6| 5| 3| 3| 3| 6| 3| 3| 3| 7| 3| |
| 3| 5| 2| 2| 5| 2| 0| 1| 2| 3| 2| 2| 2| 5| 5| 3| 2| 2| 3| 5| 2| 1| 1| 8| 3| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
4.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 1 1.0|
Respiratory Epithelium, Epiglottis, | | |
Metaplasia, Squamous | 1 1 1 1 1 1 1 1 1 2 1 1 2 1 1 1 1 1 1 1 1| 44 1.1|
Squamous Epithelium, Hyperplasia | 2 1 1 1 1 1 1 | 14 1.1|
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 4 1.3|
Inflammation, Chronic | 2 2 2 2 3 2 2 2 2 2 2 2 2 1 2 2 3 2 2 1 2 2 2 1 | 49 2.0|
Alveolar Epithelium, Hyperplasia | 4 2 3 4 2 2 4 4 4 2 3 4 2 1 4 4 4 2 4 4 4 4 4 2 4| 50 3.3|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 3 2 4 4 2 2 3 2 1 2 2 2 3 4 2 4 3 4 2 4 2| 45 2.7|
Bronchiole, Epithelium, Hyperplasia | 1 1 1 1 1 2 2 2 2 1 1 1 2 2 1 1 2 2 2 1 2 2 2 2| 48 1.5|
Interstitium, Fibrosis | 1 2 1 | 8 1.5|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphocyte | 4 | 1 4.0|
Inflammation, Suppurative | 1 1 1 1 1 1 2 1 1 1 1 2 2 2 2 | 30 1.3|
Lateral Wall, Hyperplasia | 2 1 | 2 1.5|
Lateral Wall, Metaplasia, Squamous | 1 | 1 1.0|
Olfactory Epithelium, Atrophy | 2 2 1 1 1 | 14 1.3|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 2 2 2 1 1 1 1 1 1 1 1 2 1 1 2 1 1 1 1 1 2 1 1| 48 1.3|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 2 2 2 2 2 2 2 2 2 2 2 2 1 1 1 1 2 2 2 1 1 2 2 1 2| 50 1.8|
Respiratory Epithelium, Hyperplasia | 1 | 1 1.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 2 1 1 1 | 8 1.1|
Respiratory Epithelium, Necrosis | 2 1 2 | 7 1.4|
|__________________________________________________________________________|____________|
Pleura | + | 1 |
Mesothelium, Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 6| 7| 7| 2| 5| 6| 7| 7| 7| 5| 7| 7| 7| 4| 7| |
DAY ON TEST | 3| 0| 3| 3| 2| 4| 5| 3| 3| 3| 1| 3| 3| 5| 6| 5| 3| 3| 3| 6| 3| 3| 3| 7| 3| |
| 3| 5| 2| 2| 5| 2| 0| 1| 2| 3| 2| 2| 2| 5| 5| 3| 2| 2| 3| 5| 2| 1| 1| 8| 3| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
4.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Metaplasia, Squamous | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accumulation, Hyaline Droplet | 3 | 1 3.0|
Cyst | | 1 1.0|
Metaplasia, Osseous | | 2 1.0|
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2| 39 1.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
_____________________________________________________________________________________________________________________
| 7| 6| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 3| 2| 2| 3| 3| 2| 2| 2| 2| 3| 3| 3| 3| 3| 0| 3| 2| 3| 2| 3| 2| 2| 3|
| 0| 0| 0| 3| 9| 0| 0| 9| 4| 0| 9| 1| 0| 1| 0| 1| 1| 1| 9| 0| 9| 1| 9| 9| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 |
|__________________________________________________________________________|
Gallbladder | + + M M + + + I M M I + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + A + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + A + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + A + A + + + + A + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + A + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + A + A + + + + A + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + A + A + + + + A + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Clear Cell Focus | |
Eosinophilic Focus | X X X X X X X X X|
Eosinophilic Focus, Multiple | |
Inflammation, Focal, Granulomatous | 1 |
Mixed Cell Focus | |
Necrosis, Focal | 1 1 1 1 |
Tension Lipidosis | X |
Vacuolization Cytoplasmic | |
Centrilobular, Degeneration | 2 |
|__________________________________________________________________________|
Mesentery | + + + |
Artery, Inflammation | |
Fat, Inflammation | 3 |
Fat, Necrosis | 3 2 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
__________________________________________|__________________________________________________________________________|
Page 47
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
_____________________________________________________________________________________________________________________
| 7| 6| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 3| 2| 2| 3| 3| 2| 2| 2| 2| 3| 3| 3| 3| 3| 0| 3| 2| 3| 2| 3| 2| 2| 3|
| 0| 0| 0| 3| 9| 0| 0| 9| 4| 0| 9| 1| 0| 1| 0| 1| 1| 1| 9| 0| 9| 1| 9| 9| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
Epithelium, Hyperplasia | 1 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tongue | |
|__________________________________________________________________________|
Tooth | + |
Malformation | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Cardiomyopathy | 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2|
Thrombosis | |
Artery, Inflammation | 2|
Capillary, Hyperplasia | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 2 4 2 1 1 |
Hypertrophy | 1 1 1 3 3 1 1 2 1 2 1 2 1 1 1 3 1 1 1 1 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 2 2 2|
|__________________________________________________________________________|
Parathyroid Gland | + + + M + M M + + + + + + M M M + M + I + M + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | |
__________________________________________|__________________________________________________________________________|
Page 48
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
_____________________________________________________________________________________________________________________
| 7| 6| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 3| 2| 2| 3| 3| 2| 2| 2| 2| 3| 3| 3| 3| 3| 0| 3| 2| 3| 2| 3| 2| 2| 3|
| 0| 0| 0| 3| 9| 0| 0| 9| 4| 0| 9| 1| 0| 1| 0| 1| 1| 1| 9| 0| 9| 1| 9| 9| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Pars Distalis, Hyperplasia | 2 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + M + + + M + + + + + +|
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | |
Inflammation | |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
Ectasia | 4 2 3 3 3 4 4 3 3 |
Inflammation | 1 1 |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 1 2|
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Degeneration | 2 |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 1 |
Interstitial Cell, Hyperplasia | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2|
Thrombosis | |
|__________________________________________________________________________|
Lymph Node, Bronchial | M M + M M + + + + + + + + + + + + + + + + + M + +|
Hyperplasia | 2 3 2 2 2|
|__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + M M + + + + + + M + M M + + + + M +|
__________________________________________|__________________________________________________________________________|
Page 49
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
_____________________________________________________________________________________________________________________
| 7| 6| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 3| 2| 2| 3| 3| 2| 2| 2| 2| 3| 3| 3| 3| 3| 0| 3| 2| 3| 2| 3| 2| 2| 3|
| 0| 0| 0| 3| 9| 0| 0| 9| 4| 0| 9| 1| 0| 1| 0| 1| 1| 1| 9| 0| 9| 1| 9| 9| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Hyperplasia | 3 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + + + + + + + + + + + + + + + + + + + M|
Hyperplasia | 2 |
|__________________________________________________________________________|
Lymph Node, Mediastinal | + + + M M + M + M M + + + + + + + + + + M + M M +|
Hyperplasia | 2 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 1 2 1|
Hyperplasia, Lymphoid | 2 2 2 |
|__________________________________________________________________________|
Thymus | + M M + + I + M M + M M + M + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Inflammation, Focal, Granulomatous | 4 |
Inflammation, Suppurative | |
Epidermis, Hyperplasia | |
Prepuce, Inflammation, Chronic Active| 2 4 2|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + A + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________|__________________________________________________________________________|
Page 50
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
_____________________________________________________________________________________________________________________
| 7| 6| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 3| 2| 2| 3| 3| 2| 2| 2| 2| 3| 3| 3| 3| 3| 0| 3| 2| 3| 2| 3| 2| 2| 3|
| 0| 0| 0| 3| 9| 0| 0| 9| 4| 0| 9| 1| 0| 1| 0| 1| 1| 1| 9| 0| 9| 1| 9| 9| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Respiratory Epithelium, Epiglottis, | |
Metaplasia, Squamous | 1 |
Squamous Epithelium, Hyperplasia | 1 1 |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Chronic | 1 2 |
Inflammation, Suppurative | |
Alveolar Epithelium, Hyperplasia | 4 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 2 3 3 |
Interstitium, Fibrosis | 1 |
Mediastinum, Inflammation | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 1 1 1 1|
Olfactory Epithelium, Atrophy | 1 |
Olfactory Epithelium, Degeneration, | |
Hyaline | |
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 1 |
|__________________________________________________________________________|
Trachea | + A + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Harderian Gland | + + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 2 1 2 |
Metaplasia, Osseous | |
Nephropathy | 2 2 1 1 1 2 1 1 2 3 1 2 1 1 1 1 1 1 1 1 1 2 3|
Papilla, Necrosis | 2 |
Renal Tubule, Hyperplasia | 1 1 |
Renal Tubule, Necrosis | 1 |
__________________________________________|__________________________________________________________________________|
Page 51
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
_____________________________________________________________________________________________________________________
| 7| 6| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 3| 2| 2| 3| 3| 2| 2| 2| 2| 3| 3| 3| 3| 3| 0| 3| 2| 3| 2| 3| 2| 2| 3|
| 0| 0| 0| 3| 9| 0| 0| 9| 4| 0| 9| 1| 0| 1| 0| 1| 1| 1| 9| 0| 9| 1| 9| 9| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 52
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| |
DAY ON TEST | 2| 3| 2| 2| 9| 2| 3| 3| 3| 2| 3| 2| 6| 9| 3| 2| 1| 2| 3| 3| 3| 9| 0| 3| 3| |
| 9| 0| 9| 9| 2| 9| 0| 0| 1| 9| 1| 9| 7| 9| 0| 9| 0| 9| 0| 0| 1| 8| 3| 0| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 2 | 2 1.5|
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + M A + +| 42 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + A + +| 48 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + A + +| 46 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + A + +| 46 |
Inflammation, Chronic | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X | 2 |
Clear Cell Focus | X X X X | 4 |
Eosinophilic Focus | X X X X X X X X X X | 19 |
Eosinophilic Focus, Multiple | X | 1 |
Inflammation, Focal, Granulomatous | 1 | 2 1.0|
Mixed Cell Focus | X | 1 |
Necrosis, Focal | 1 1 1 1 | 8 1.0|
Tension Lipidosis | X | 2 |
Vacuolization Cytoplasmic | 2| 1 2.0|
Centrilobular, Degeneration | | 1 2.0|
|__________________________________________________________________________|____________|
Mesentery | + + + + + + | 9 |
Artery, Inflammation | 2 | 1 2.0|
Fat, Inflammation | 2 2 | 3 2.3|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| |
DAY ON TEST | 2| 3| 2| 2| 9| 2| 3| 3| 3| 2| 3| 2| 6| 9| 3| 2| 1| 2| 3| 3| 3| 9| 0| 3| 3| |
| 9| 0| 9| 9| 2| 9| 0| 0| 1| 9| 1| 9| 7| 9| 0| 9| 0| 9| 0| 0| 1| 8| 3| 0| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Fat, Necrosis | 2 3 4 | 5 2.8|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 1 | 3 1.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | 1 | 1 1.0|
Epithelium, Hyperplasia | 2 4 | 3 2.3|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Tongue | + | 1 |
|__________________________________________________________________________|____________|
Tooth | + | 2 |
Malformation | X | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 1.0|
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 2 1 1 1 1| 48 1.1|
Thrombosis | 3 | 1 3.0|
Artery, Inflammation | | 1 2.0|
Capillary, Hyperplasia | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 4 2 4 | 9 2.7|
Hypertrophy | 1 2 1 1 3 1 2 1 3 1 1 1 1 1 1 1 2 1 2 2| 40 1.5|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| |
DAY ON TEST | 2| 3| 2| 2| 9| 2| 3| 3| 3| 2| 3| 2| 6| 9| 3| 2| 1| 2| 3| 3| 3| 9| 0| 3| 3| |
| 9| 0| 9| 9| 2| 9| 0| 0| 1| 9| 1| 9| 7| 9| 0| 9| 0| 9| 0| 0| 1| 8| 3| 0| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 1 2 1 1 | 11 1.4|
|__________________________________________________________________________|____________|
Parathyroid Gland | + M M + M + I M + + M + M + + + + + + + + + M + +| 33 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Cyst | 2 1 | 2 1.5|
Pars Distalis, Hyperplasia | 1 2 1| 4 1.5|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Follicular Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma Sperm | 3 | 1 3.0|
Inflammation | 1 1 2 | 3 1.3|
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Ectasia | 4 4 3 2 2 4| 15 3.2|
Inflammation | | 2 1.0|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 3 | 4 2.0|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Degeneration | | 1 2.0|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 1 | 4 1.8|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| |
DAY ON TEST | 2| 3| 2| 2| 9| 2| 3| 3| 3| 2| 3| 2| 6| 9| 3| 2| 1| 2| 3| 3| 3| 9| 0| 3| 3| |
| 9| 0| 9| 9| 2| 9| 0| 0| 1| 9| 1| 9| 7| 9| 0| 9| 0| 9| 0| 0| 1| 8| 3| 0| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Interstitial Cell, Hyperplasia | | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 2 2 2 | 8 2.0|
Thrombosis | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M + + M + + + + + M + + M + + + + + M + + + + +| 40 |
Hyperplasia | 2 2 | 7 2.1|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M + M + + + + + M M + M + + + M + + + M + M M| 34 |
Hyperplasia | | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + M + + + + + M + + + + + + + + + + + + + +| 46 |
Hyperplasia | 2 2 | 3 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + + M + + + + + + + + + + M + + + + + + + + + M| 38 |
Hyperplasia | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 2 1 2 2 2 2 1 3 2 2 | 15 1.8|
Hyperplasia, Lymphoid | 2 2 2 2 2 2 | 9 2.0|
|__________________________________________________________________________|____________|
Thymus | + + M M + + + + + + + + M M + + M + + + + + M M +| 35 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | | 1 |
Inflammation, Focal, Granulomatous | | 1 4.0|
Inflammation, Suppurative | 1 | 1 1.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| |
DAY ON TEST | 2| 3| 2| 2| 9| 2| 3| 3| 3| 2| 3| 2| 6| 9| 3| 2| 1| 2| 3| 3| 3| 9| 0| 3| 3| |
| 9| 0| 9| 9| 2| 9| 0| 0| 1| 9| 1| 9| 7| 9| 0| 9| 0| 9| 0| 0| 1| 8| 3| 0| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
Epidermis, Hyperplasia | 2 2 | 2 2.0|
Prepuce, Inflammation, Chronic Active| 3 2 2 4 | 7 2.7|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 2 1 | 2 1.5|
Respiratory Epithelium, Epiglottis, | | |
Metaplasia, Squamous | 1| 2 1.0|
Squamous Epithelium, Hyperplasia | 1 1 1 | 5 1.0|
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 2 | 2 2.0|
Inflammation, Chronic | 2 1 1 2 | 6 1.5|
Inflammation, Suppurative | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | 4 1 | 3 3.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 2 2 4 2 3 | 10 2.4|
Interstitium, Fibrosis | | 1 1.0|
Mediastinum, Inflammation | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 4 1 1 1 1 1 1 2 1 1 | 16 1.3|
Olfactory Epithelium, Atrophy | 1 1 1 1 1 | 6 1.0|
Olfactory Epithelium, Degeneration, | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| |
DAY ON TEST | 2| 3| 2| 2| 9| 2| 3| 3| 3| 2| 3| 2| 6| 9| 3| 2| 1| 2| 3| 3| 3| 9| 0| 3| 3| |
| 9| 0| 9| 9| 2| 9| 0| 0| 1| 9| 1| 9| 7| 9| 0| 9| 0| 9| 0| 0| 1| 8| 3| 0| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Hyaline | 1 | 1 1.0|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 2 1 1 1 1 1 | 8 1.1|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Harderian Gland | + + + +| 8 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 1 | 5 1.4|
Metaplasia, Osseous | 1 1 | 2 1.0|
Nephropathy | 1 1 1 1 3 2 1 1 1 1 2 1 1 1 1 1 2 1 1 1 1 2 1 1 1| 48 1.3|
Papilla, Necrosis | 1 | 2 1.5|
Renal Tubule, Hyperplasia | 1 1 1 | 5 1.0|
Renal Tubule, Necrosis | | 1 1.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
_____________________________________________________________________________________________________________________
| 6| 7| 5| 5| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 5| 3| 2| 2| 2| 3| 3| 2| 3| 3| 1| 3| 3| 6| 3| 2| 1| 3| 3| 3| 2| 1| 1|
| 9| 0| 8| 0| 9| 9| 6| 0| 0| 9| 0| 1| 4| 0| 1| 7| 1| 9| 4| 0| 1| 0| 2| 4| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + M + + + + + + + + + + A + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + A + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | |
Clear Cell Focus, Multiple | X |
Eosinophilic Focus | X X X X X X |
Eosinophilic Focus, Multiple | X X X |
Hematopoietic Cell Proliferation | |
Infarct | 4 |
Inflammation, Focal, Granulomatous | 2 2 1 |
Necrosis, Focal | 1 1 |
Tension Lipidosis | X |
Vacuolization Cytoplasmic | 2 |
Centrilobular, Degeneration | |
Centrilobular, Necrosis | |
|__________________________________________________________________________|
Mesentery | + + + + + + |
Fat, Necrosis | 2 4 |
|__________________________________________________________________________|
Oral Mucosa | |
Pharyngeal, Cyst | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 59
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
_____________________________________________________________________________________________________________________
| 6| 7| 5| 5| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 5| 3| 2| 2| 2| 3| 3| 2| 3| 3| 1| 3| 3| 6| 3| 2| 1| 3| 3| 3| 2| 1| 1|
| 9| 0| 8| 0| 9| 9| 6| 0| 0| 9| 0| 1| 4| 0| 1| 7| 1| 9| 4| 0| 1| 0| 2| 4| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Atrophy | 1 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 2 |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1|
Mineralization | |
Ulcer | 1 |
Epithelium, Hyperplasia | 2 2 2 2 1|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular | |
Inflammation, Suppurative | 1|
Epithelium, Hyperplasia | 1|
|__________________________________________________________________________|
Tooth | |
Inflammation | |
Malformation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 2 1 1 1 1|
Mineralization | 1 |
Artery, Inflammation | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | M + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 |
Hypertrophy | 1 2 1 1 1 2 2 2 2 2 1 1 2 2 1 1 |
|__________________________________________________________________________|
Adrenal Medulla | M + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 4 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 1 1 |
__________________________________________|__________________________________________________________________________|
Page 60
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
_____________________________________________________________________________________________________________________
| 6| 7| 5| 5| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 5| 3| 2| 2| 2| 3| 3| 2| 3| 3| 1| 3| 3| 6| 3| 2| 1| 3| 3| 3| 2| 1| 1|
| 9| 0| 8| 0| 9| 9| 6| 0| 0| 9| 0| 1| 4| 0| 1| 7| 1| 9| 4| 0| 1| 0| 2| 4| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
|__________________________________________________________________________|
Parathyroid Gland | + + M + + + M + + + + + + + + + + + + + + + M + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 2 1 2|
Pars Distalis, Hyperplasia | 2 1 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 2 2 2 4 3 2 3 2 4 3 3|
Inflammation | 2 4 |
|__________________________________________________________________________|
Prostate | M + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 |
Inflammation, Suppurative | |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Inflammation, Chronic | 1 |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 |
|__________________________________________________________________________|
Lymph Node | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 61
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
_____________________________________________________________________________________________________________________
| 6| 7| 5| 5| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 5| 3| 2| 2| 2| 3| 3| 2| 3| 3| 1| 3| 3| 6| 3| 2| 1| 3| 3| 3| 2| 1| 1|
| 9| 0| 8| 0| 9| 9| 6| 0| 0| 9| 0| 1| 4| 0| 1| 7| 1| 9| 4| 0| 1| 0| 2| 4| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Lymph Node, Bronchial | + + + + + + + + + + + + M M I + M + + M + + + + +|
Hyperplasia | 3 2 2 4 |
|__________________________________________________________________________|
Lymph Node, Mandibular | M M + + + + M + + + + M + + + + + + M M + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 |
Hyperplasia | 2 2 3|
|__________________________________________________________________________|
Lymph Node, Mediastinal | + + M + + + M M M + + + M + + + M + + M + + M + M|
Hyperplasia | 2 1 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hematopoietic Cell Proliferation | 2 3 2 2 3 |
Hyperplasia, Lymphoid | 2 2 2 2 2 4 2|
Infiltration Cellular, Histiocyte | 2 |
|__________________________________________________________________________|
Thymus | + M + + + + + + M + + + + + + + M M + + + + M + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Prepuce, Inflammation, Chronic Active| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 1 1 |
|__________________________________________________________________________|
Skeletal Muscle | + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Meninges, Infiltration Cellular, | |
__________________________________________|__________________________________________________________________________|
Page 62
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
_____________________________________________________________________________________________________________________
| 6| 7| 5| 5| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 5| 3| 2| 2| 2| 3| 3| 2| 3| 3| 1| 3| 3| 6| 3| 2| 1| 3| 3| 3| 2| 1| 1|
| 9| 0| 8| 0| 9| 9| 6| 0| 0| 9| 0| 1| 4| 0| 1| 7| 1| 9| 4| 0| 1| 0| 2| 4| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM - cont | |
Mononuclear Cell | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Respiratory Epithelium, Epiglottis, | |
Metaplasia, Squamous | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1|
Squamous Epithelium, Hyperplasia | 2 1 |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Inflammation, Chronic | 2 1 2 3 2 2 1 1 1 1 2 1 2 1 1 2 1 2 1 3 1 1|
Necrosis | 4 |
Thrombosis | |
Alveolar Epithelium, Hyperplasia | 1 3 2 2 2 2 4 2 2 2 2 4 1 4 1 2 4 2 2|
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 3 3 3 1 2 1 2 2 1 3 4 3 2 1 2 4 2 |
Bronchiole, Epithelium, Hyperplasia | 1 1 1 1 1 1 1 |
Interstitium, Fibrosis | 2 2 1 |
Mediastinum, Inflammation | 2 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 4 |
Inflammation, Suppurative | 1 1 1 1 1 4 2 |
Lateral Wall, Metaplasia, Squamous | 2 |
Olfactory Epithelium, Atrophy | 4 2 1|
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 1 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 1 1 1 1 1 1 1 1 1 1 1|
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 2 |
|__________________________________________________________________________|
Pleura | + |
Mesothelium, Hyperplasia | 4 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 63
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
_____________________________________________________________________________________________________________________
| 6| 7| 5| 5| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 5| 3| 2| 2| 2| 3| 3| 2| 3| 3| 1| 3| 3| 6| 3| 2| 1| 3| 3| 3| 2| 1| 1|
| 9| 0| 8| 0| 9| 9| 6| 0| 0| 9| 0| 1| 4| 0| 1| 7| 1| 9| 4| 0| 1| 0| 2| 4| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Ear | + |
|__________________________________________________________________________|
Harderian Gland | + + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Cyst | 1 1 |
Hydronephrosis | |
Infiltration Cellular, Lipocyte | 2 |
Metaplasia, Osseous | 1 1 1 1 |
Mineralization | |
Nephropathy | 1 1 1 1 1 2 1 1 1 1 2 1 1 2 1 1 1 1 1 1 2 1 2 1 1|
Renal Tubule, Hyperplasia | 1 1 1 |
Renal Tubule, Necrosis | 2 1 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 64
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
__________________________________________________________________________________________________________________________________
| 6| 5| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| |
DAY ON TEST | 6| 9| 3| 2| 2| 2| 2| 0| 2| 3| 3| 3| 3| 3| 2| 3| 2| 2| 3| 3| 3| 9| 2| 3| 3| |
| 6| 0| 4| 9| 9| 9| 9| 5| 8| 0| 0| 0| 1| 1| 9| 0| 9| 9| 1| 9| 0| 5| 9| 0| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
1.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + A A + + + + M + + + M + + + + + + M| 43 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + A + + + + + + + + + + M + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + A A + + + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + A A + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + A + + +| 49 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Clear Cell Focus | X X | 2 |
Clear Cell Focus, Multiple | | 1 |
Eosinophilic Focus | X X X X X | 11 |
Eosinophilic Focus, Multiple | X X| 5 |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Infarct | | 1 4.0|
Inflammation, Focal, Granulomatous | 1 1 1 | 6 1.3|
Necrosis, Focal | 2 | 3 1.3|
Tension Lipidosis | X X X | 4 |
Vacuolization Cytoplasmic | | 1 2.0|
Centrilobular, Degeneration | 1 | 1 1.0|
Centrilobular, Necrosis | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Mesentery | + | 7 |
Fat, Necrosis | 2 | 3 2.7|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 65
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
__________________________________________________________________________________________________________________________________
| 6| 5| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| |
DAY ON TEST | 6| 9| 3| 2| 2| 2| 2| 0| 2| 3| 3| 3| 3| 3| 2| 3| 2| 2| 3| 3| 3| 9| 2| 3| 3| |
| 6| 0| 4| 9| 9| 9| 9| 5| 8| 0| 0| 0| 1| 1| 9| 0| 9| 9| 1| 9| 0| 5| 9| 0| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
1.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Oral Mucosa | + | 1 |
Pharyngeal, Cyst | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 1 | 3 1.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 3 1 | 4 1.8|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 | 2 1.0|
Mineralization | 1 | 1 1.0|
Ulcer | 1 | 2 1.0|
Epithelium, Hyperplasia | 2 2 1 2 4| 10 2.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 |
Infiltration Cellular | 2 | 1 2.0|
Inflammation, Suppurative | | 1 1.0|
Epithelium, Hyperplasia | | 1 1.0|
|__________________________________________________________________________|____________|
Tooth | + | 1 |
Inflammation | 2 | 1 2.0|
Malformation | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 2 1 1 1 1 1 2 1 1| 48 1.1|
Mineralization | | 1 1.0|
Artery, Inflammation | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 66
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
__________________________________________________________________________________________________________________________________
| 6| 5| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| |
DAY ON TEST | 6| 9| 3| 2| 2| 2| 2| 0| 2| 3| 3| 3| 3| 3| 2| 3| 2| 2| 3| 3| 3| 9| 2| 3| 3| |
| 6| 0| 4| 9| 9| 9| 9| 5| 8| 0| 0| 0| 1| 1| 9| 0| 9| 9| 1| 9| 0| 5| 9| 0| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
1.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Degeneration, Cystic | | 1 2.0|
Hypertrophy | 1 1 1 1 1 1 1 1 1 2 2 2 1 2 1 2 1 2 1 2| 36 1.4|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 2 2.5|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 6 1.0|
|__________________________________________________________________________|____________|
Parathyroid Gland | + M M M + + + + + + M + + + + + + + + + + + + + +| 43 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + I + + + + I + + + + + + + + + + + + + + + +| 48 |
Pars Distalis, Cyst | | 3 1.7|
Pars Distalis, Hyperplasia | 2 | 3 1.7|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 2 3 3 2 2 3 2 | 19 2.6|
Inflammation | 2 2 2 | 5 2.4|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation | | 1 1.0|
Inflammation, Suppurative | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 67
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
__________________________________________________________________________________________________________________________________
| 6| 5| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| |
DAY ON TEST | 6| 9| 3| 2| 2| 2| 2| 0| 2| 3| 3| 3| 3| 3| 2| 3| 2| 2| 3| 3| 3| 9| 2| 3| 3| |
| 6| 0| 4| 9| 9| 9| 9| 5| 8| 0| 0| 0| 1| 1| 9| 0| 9| 9| 1| 9| 0| 5| 9| 0| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
1.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Inflammation, Chronic | 3 | 2 2.0|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 1 1 2| 7 1.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 | 5 2.0|
|__________________________________________________________________________|____________|
Lymph Node | + | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M + + + + M + + M + + M M + + + + + + M + + M +| 38 |
Hyperplasia | 2 2 2 | 7 2.4|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + + + + + + +| 43 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M M + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Hematopoietic Cell Proliferation | | 1 2.0|
Hyperplasia | 2 1 2 2 | 7 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + + + + + + + M M + + + M + + + + + + + + + + M| 36 |
Hyperplasia | 2 | 3 1.7|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 3| 13 2.2|
Hyperplasia, Lymphoid | 2 2 2 2 4 | 12 2.3|
Infiltration Cellular, Histiocyte | | 1 2.0|
|__________________________________________________________________________|____________|
Thymus | + M + + + + + + M + + + + + + + M + M + + + + + +| 40 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 68
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
__________________________________________________________________________________________________________________________________
| 6| 5| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| |
DAY ON TEST | 6| 9| 3| 2| 2| 2| 2| 0| 2| 3| 3| 3| 3| 3| 2| 3| 2| 2| 3| 3| 3| 9| 2| 3| 3| |
| 6| 0| 4| 9| 9| 9| 9| 5| 8| 0| 0| 0| 1| 1| 9| 0| 9| 9| 1| 9| 0| 5| 9| 0| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
1.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Prepuce, Inflammation, Chronic Active| 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 1 | 3 1.0|
|__________________________________________________________________________|____________|
Skeletal Muscle | | 3 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Meninges, Infiltration Cellular, | | |
Mononuclear Cell | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Respiratory Epithelium, Epiglottis, | | |
Metaplasia, Squamous | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 45 1.0|
Squamous Epithelium, Hyperplasia | 1 1| 4 1.3|
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 1| 3 1.3|
Inflammation, Chronic | 1 3 2 1 1 1 1 1 1 3 1 2 1 2 2 2 2 1 1 1| 42 1.5|
Necrosis | | 1 4.0|
Thrombosis | 1 | 1 1.0|
Alveolar Epithelium, Hyperplasia | 2 1 4 2 4 2 2 4 2 1 1 1 2 4 2 1 1 3 2 3 2 2| 41 2.2|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 4 4 3 2 1 1 2 2 4 3 2 2 4 4 1 2 2 3| 36 2.4|
Bronchiole, Epithelium, Hyperplasia | 1 1 1 1 1 1 1 1 | 15 1.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 69
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
__________________________________________________________________________________________________________________________________
| 6| 5| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| |
DAY ON TEST | 6| 9| 3| 2| 2| 2| 2| 0| 2| 3| 3| 3| 3| 3| 2| 3| 2| 2| 3| 3| 3| 9| 2| 3| 3| |
| 6| 0| 4| 9| 9| 9| 9| 5| 8| 0| 0| 0| 1| 1| 9| 0| 9| 9| 1| 9| 0| 5| 9| 0| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
1.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Interstitium, Fibrosis | 2 2 1 | 6 1.7|
Mediastinum, Inflammation | | 1 2.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | | 1 4.0|
Inflammation, Suppurative | 1 1 1 1 | 11 1.4|
Lateral Wall, Metaplasia, Squamous | | 1 2.0|
Olfactory Epithelium, Atrophy | 1 1 1 1 | 7 1.6|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 1 1 1 1 | 7 1.0|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 1 1 1 1 1 1 1 2 1 1| 22 1.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 1 1 1 1 | 6 1.2|
|__________________________________________________________________________|____________|
Pleura | + + + | 4 |
Mesothelium, Hyperplasia | 1 2 2 | 4 2.3|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Ear | | 1 |
|__________________________________________________________________________|____________|
Harderian Gland | + | 5 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 4 | 1 4.0|
Cyst | 2 | 3 1.3|
Hydronephrosis | 2 2 | 2 2.0|
Infiltration Cellular, Lipocyte | | 1 2.0|
Metaplasia, Osseous | 1 1 1 | 7 1.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 70
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
__________________________________________________________________________________________________________________________________
| 6| 5| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| |
DAY ON TEST | 6| 9| 3| 2| 2| 2| 2| 0| 2| 3| 3| 3| 3| 3| 2| 3| 2| 2| 3| 3| 3| 9| 2| 3| 3| |
| 6| 0| 4| 9| 9| 9| 9| 5| 8| 0| 0| 0| 1| 1| 9| 0| 9| 9| 1| 9| 0| 5| 9| 0| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
1.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
Mineralization | 3 | 1 3.0|
Nephropathy | 1 3 2 2 2 1 1 1 1 1 2 1 1 1 1 1 1 1 1 3 1 1 2 1 3| 50 1.3|
Renal Tubule, Hyperplasia | 1 1 1 1 | 7 1.0|
Renal Tubule, Necrosis | | 2 1.5|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 71
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 5| 4| 7| 7| 7| 6| 7| 7| 6| 7| 7|
DAY ON TEST | 1| 0| 3| 1| 2| 9| 2| 3| 2| 5| 2| 3| 2| 9| 3| 2| 3| 2| 3| 3| 3| 3| 9| 3| 3|
| 8| 9| 0| 8| 9| 5| 9| 1| 9| 3| 9| 1| 9| 5| 4| 2| 1| 9| 0| 9| 0| 0| 5| 0| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + + + + + + M + + + + + + + + M + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Eosinophilic Focus | X X X X X X X X|
Eosinophilic Focus, Multiple | X X |
Inflammation, Focal, Granulomatous | 1 1 1 2 |
Necrosis, Focal | 2 1 1 |
Pigmentation, Hemosiderin | 2 2 |
Tension Lipidosis | X X |
Centrilobular, Degeneration | 2 |
|__________________________________________________________________________|
Mesentery | + + |
Fat, Inflammation | |
Fat, Necrosis | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 2 |
Necrosis | 2 |
__________________________________________|__________________________________________________________________________|
Page 72
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 5| 4| 7| 7| 7| 6| 7| 7| 6| 7| 7|
DAY ON TEST | 1| 0| 3| 1| 2| 9| 2| 3| 2| 5| 2| 3| 2| 9| 3| 2| 3| 2| 3| 3| 3| 3| 9| 3| 3|
| 8| 9| 0| 8| 9| 5| 9| 1| 9| 3| 9| 1| 9| 5| 4| 2| 1| 9| 0| 9| 0| 0| 5| 0| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Ulcer | 1 2 |
Epithelium, Hyperplasia | 2 4 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Mineralization | 1 |
Ulcer | |
|__________________________________________________________________________|
Tooth | + |
Malformation | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 3 1 1 2 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 2 2 1 1 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Hypertrophy | 1 1 3 1 1 2 1 1 1 1 2 1 1 2 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + M + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Parathyroid Gland | M M + + + + + + + + + + + M + + + + M + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 1 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
__________________________________________|__________________________________________________________________________|
Page 73
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 5| 4| 7| 7| 7| 6| 7| 7| 6| 7| 7|
DAY ON TEST | 1| 0| 3| 1| 2| 9| 2| 3| 2| 5| 2| 3| 2| 9| 3| 2| 3| 2| 3| 3| 3| 3| 9| 3| 3|
| 8| 9| 0| 8| 9| 5| 9| 1| 9| 3| 9| 1| 9| 5| 4| 2| 1| 9| 0| 9| 0| 0| 5| 0| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 2 3 2 2 2 2 |
Inflammation | 4 1 |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 |
|__________________________________________________________________________|
Lymph Node, Bronchial | M + + + + + + + M + + + + + + M + M + M + + + M +|
Hyperplasia | 2 2 2 2 3 2|
|__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + M + + M M + M M + M M + + + + M + M +|
Hyperplasia | 2 |
Infiltration Cellular, Plasma Cell | |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + M + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 1 |
Hyperplasia | 2 |
|__________________________________________________________________________|
Lymph Node, Mediastinal | + M + + + + + + + + + + + + + M + + + M + + + + M|
Hyperplasia | 2 3 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 2 2 3 2 2 2 1 2|
Hyperplasia, Lymphoid | 2 2 2 2 2 |
__________________________________________|__________________________________________________________________________|
Page 74
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 5| 4| 7| 7| 7| 6| 7| 7| 6| 7| 7|
DAY ON TEST | 1| 0| 3| 1| 2| 9| 2| 3| 2| 5| 2| 3| 2| 9| 3| 2| 3| 2| 3| 3| 3| 3| 9| 3| 3|
| 8| 9| 0| 8| 9| 5| 9| 1| 9| 3| 9| 1| 9| 5| 4| 2| 1| 9| 0| 9| 0| 0| 5| 0| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
|__________________________________________________________________________|
Thymus | I M M M + + + + + M M + + + + M + + + M + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Prepuce, Inflammation, Chronic Active| 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | |
Fracture | X |
|__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spinal Cord | |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 |
Respiratory Epithelium, Epiglottis, | |
Metaplasia, Squamous | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Squamous Epithelium, Hyperplasia | 1 1 1 1|
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Inflammation, Chronic | 1 2 1 2 2 2 1 2 1 2 2 3 2 2 2 1 1 1 1 2 1 1|
Alveolar Epithelium, Hyperplasia | 2 3 4 4 2 2 4 4 4 4 4 4 4 3 2 4 3 4 2 4 4 2 4 4|
__________________________________________|__________________________________________________________________________|
Page 75
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 5| 4| 7| 7| 7| 6| 7| 7| 6| 7| 7|
DAY ON TEST | 1| 0| 3| 1| 2| 9| 2| 3| 2| 5| 2| 3| 2| 9| 3| 2| 3| 2| 3| 3| 3| 3| 9| 3| 3|
| 8| 9| 0| 8| 9| 5| 9| 1| 9| 3| 9| 1| 9| 5| 4| 2| 1| 9| 0| 9| 0| 0| 5| 0| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 4 2 3 3 4 4 2 2 2 3 2 3 4 4 2 1 2 1 3 4 2 2|
Bronchiole, Epithelium, Hyperplasia | 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1|
Interstitium, Fibrosis | 1 1 1 1 1 2 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Inflammation, Chronic | 2 |
Inflammation, Suppurative | 2 2 1 1 1 1 1 2 1 2 1 1 1 1 1 |
Lateral Wall, Hyperplasia | 1 |
Lateral Wall, Metaplasia, Squamous | 1 |
Olfactory Epithelium, Atrophy | 1 2 2 1 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 1 1 1 1 1 2 1 2 1 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 1 1 1 1 1 2 1 2 1 1 1 1 1 1 1 2 2 1 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 1 2 |
Respiratory Epithelium, Necrosis | 1 |
|__________________________________________________________________________|
Pleura | + |
Mesothelium, Hyperplasia | 2 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + I + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + |
|__________________________________________________________________________|
Harderian Gland | + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 1 1 2 |
Infarct, Chronic | |
Metaplasia, Osseous | 1 1 |
Nephropathy | 1 2 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 2 1 2 2 1 1|
__________________________________________|__________________________________________________________________________|
Page 76
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 5| 4| 7| 7| 7| 6| 7| 7| 6| 7| 7|
DAY ON TEST | 1| 0| 3| 1| 2| 9| 2| 3| 2| 5| 2| 3| 2| 9| 3| 2| 3| 2| 3| 3| 3| 3| 9| 3| 3|
| 8| 9| 0| 8| 9| 5| 9| 1| 9| 3| 9| 1| 9| 5| 4| 2| 1| 9| 0| 9| 0| 0| 5| 0| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
Renal Tubule, Hyperplasia | 1 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | |
__________________________________________|__________________________________________________________________________
Page 77
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 1| 3| 2| 3| 2| 1| 2| 2| 3| 2| 3| 3| 0| 3| 3| 2| 2| 3| 2| 2| 2| |
| 1| 0| 9| 0| 1| 1| 9| 0| 9| 7| 9| 9| 0| 9| 0| 1| 6| 0| 0| 9| 9| 1| 9| 9| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
2.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + A + + + + + + + + + + M + + + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation | | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 | 1 1.0|
Eosinophilic Focus | X X X X X X| 14 |
Eosinophilic Focus, Multiple | X X X | 5 |
Inflammation, Focal, Granulomatous | 1 1 1 | 7 1.1|
Necrosis, Focal | 2 1 | 5 1.4|
Pigmentation, Hemosiderin | 1 | 3 1.7|
Tension Lipidosis | | 2 |
Centrilobular, Degeneration | | 1 2.0|
|__________________________________________________________________________|____________|
Mesentery | + + + + + + | 8 |
Fat, Inflammation | 3 2 3 | 3 2.7|
Fat, Necrosis | 2 2 4 2 | 4 2.5|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 1 1 | 5 1.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 78
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 1| 3| 2| 3| 2| 1| 2| 2| 3| 2| 3| 3| 0| 3| 3| 2| 2| 3| 2| 2| 2| |
| 1| 0| 9| 0| 1| 1| 9| 0| 9| 7| 9| 9| 0| 9| 0| 1| 6| 0| 0| 9| 9| 1| 9| 9| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
2.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | | 2 1.5|
Necrosis | | 1 2.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 2 | 1 2.0|
Ulcer | | 2 1.5|
Epithelium, Hyperplasia | 2 2 1 4 | 6 2.5|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 | 1 1.0|
Mineralization | | 1 1.0|
Ulcer | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Tooth | + | 2 |
Malformation | X | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 2 1| 48 1.2|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 4 | 2 3.0|
Hypertrophy | 1 1 1 2 2 2 1 2 1 2 2 1 1 1 1 1 1| 31 1.4|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 79
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 1| 3| 2| 3| 2| 1| 2| 2| 3| 2| 3| 3| 0| 3| 3| 2| 2| 3| 2| 2| 2| |
| 1| 0| 9| 0| 1| 1| 9| 0| 9| 7| 9| 9| 0| 9| 0| 1| 6| 0| 0| 9| 9| 1| 9| 9| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
2.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + M + + + + + + + + + + + + + + + + + +| 44 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Cyst | 1 2 | 3 1.3|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 3 3 3 2 2 3| 13 2.4|
Inflammation | 4 3 2 | 5 2.8|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 1 3.0|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 4 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M + + M + + + + + + + M M + + M + + + + M + M M| 36 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 80
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 1| 3| 2| 3| 2| 1| 2| 2| 3| 2| 3| 3| 0| 3| 3| 2| 2| 3| 2| 2| 2| |
| 1| 0| 9| 0| 1| 1| 9| 0| 9| 7| 9| 9| 0| 9| 0| 1| 6| 0| 0| 9| 9| 1| 9| 9| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
2.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Hyperplasia | 2 2 2 2 2 2 | 12 2.1|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + M M + M + M + M M M + M M + + M M + + M + +| 27 |
Hyperplasia | | 1 2.0|
Infiltration Cellular, Plasma Cell | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + M + + + + + + +| 48 |
Hematopoietic Cell Proliferation | | 2 1.5|
Hyperplasia | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + M + + + + + + + + M + + + + + M| 43 |
Hyperplasia | 2 2 | 4 2.3|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 2 3 3 2 2 3 2 2 | 18 2.2|
Hyperplasia, Lymphoid | 2 2 2 2 2 2 2 2 2 2| 15 2.0|
|__________________________________________________________________________|____________|
Thymus | M + + + + + + + + M + + M + + + + + + M + + M M +| 36 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 4 | 1 4.0|
Prepuce, Inflammation, Chronic Active| | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 1 1 | 2 1.0|
Fracture | | 1 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 81
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 1| 3| 2| 3| 2| 1| 2| 2| 3| 2| 3| 3| 0| 3| 3| 2| 2| 3| 2| 2| 2| |
| 1| 0| 9| 0| 1| 1| 9| 0| 9| 7| 9| 9| 0| 9| 0| 1| 6| 0| 0| 9| 9| 1| 9| 9| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
2.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Spinal Cord | +| 1 |
Hyperplasia, Lymphoid | 2| 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 1 1 | 3 1.0|
Respiratory Epithelium, Epiglottis, | | |
Metaplasia, Squamous | 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 41 1.0|
Squamous Epithelium, Hyperplasia | 1 1 1 1 1 1 1| 11 1.0|
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 1 | 3 1.0|
Inflammation, Chronic | 2 2 2 2 1 2 1 1 3 2 1 2 2 1 1 1 1 1 1 1 1 2 2| 45 1.6|
Alveolar Epithelium, Hyperplasia | 4 3 4 4 4 2 4 4 2 4 2 3 2 3 4 4 4 4 1 2 4 4 4 2 2| 49 3.3|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 3 3 4 3 3 3 4 3 1 4 3 3 2 3 2 1 1 1 2 1 3 4| 45 2.6|
Bronchiole, Epithelium, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 2| 37 1.1|
Interstitium, Fibrosis | 2 1 1 | 9 1.2|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 2.0|
Inflammation, Chronic | | 1 2.0|
Inflammation, Suppurative | 1 1 1 1 1 1 1 2 1 1 2 1 1 1 1 1 1 | 32 1.2|
Lateral Wall, Hyperplasia | 1 | 2 1.0|
Lateral Wall, Metaplasia, Squamous | | 1 1.0|
Olfactory Epithelium, Atrophy | 2 1 1 1 1 | 9 1.3|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 1 1 1 1 2 1 1 1 1 1 1 1 | 23 1.1|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 1 1 1 1 1 1 2 1 1 2 1 1 2 2 2 1 1 1| 38 1.2|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 82
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 1| 3| 2| 3| 2| 1| 2| 2| 3| 2| 3| 3| 0| 3| 3| 2| 2| 3| 2| 2| 2| |
| 1| 0| 9| 0| 1| 1| 9| 0| 9| 7| 9| 9| 0| 9| 0| 1| 6| 0| 0| 9| 9| 1| 9| 9| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
2.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Respiratory Epithelium, Metaplasia, | | |
Squamous | 1 1 1 | 6 1.3|
Respiratory Epithelium, Necrosis | | 1 1.0|
|__________________________________________________________________________|____________|
Pleura | + | 2 |
Mesothelium, Hyperplasia | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | | 1 |
|__________________________________________________________________________|____________|
Harderian Gland | + + | 5 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 1 1 2 | 7 1.4|
Infarct, Chronic | 3 2 | 2 2.5|
Metaplasia, Osseous | 1 1 1 1 1 | 7 1.0|
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 3 1 1 1 1 1 2 2 1 1 1| 48 1.2|
Renal Tubule, Hyperplasia | 1 | 2 1.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Transitional Epithelium, Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 83
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 6| 3| 7| 7| 4| 7| 7| 6| 6| 5| 5| 7| 5| 5| 6| 5| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 2| 6| 0| 3| 9| 2| 2| 9| 2| 2| 6| 9| 8| 8| 3| 4| 3| 6| 6| 2| 2|
| 1| 1| 0| 0| 9| 7| 5| 9| 4| 9| 9| 4| 9| 9| 7| 5| 6| 6| 0| 6| 5| 7| 2| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
4.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + M + + I + + M + + + M + + + + + + + A + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + M + + + A + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + A + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Eosinophilic Focus | X X X X X X X |
Eosinophilic Focus, Multiple | X X |
Inflammation, Focal, Granulomatous | 1 1 |
Necrosis, Focal | 1 2 |
Pigmentation, Hemosiderin | |
Tension Lipidosis | X X X |
|__________________________________________________________________________|
Mesentery | +|
Fat, Necrosis | 2|
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Ulcer | |
Epithelium, Hyperplasia | 2 2 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 84
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 6| 3| 7| 7| 4| 7| 7| 6| 6| 5| 5| 7| 5| 5| 6| 5| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 2| 6| 0| 3| 9| 2| 2| 9| 2| 2| 6| 9| 8| 8| 3| 4| 3| 6| 6| 2| 2|
| 1| 1| 0| 0| 9| 7| 5| 9| 4| 9| 9| 4| 9| 9| 7| 5| 6| 6| 0| 6| 5| 7| 2| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
4.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 1 |
Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 2 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 2|
Artery, Inflammation | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypertrophy | 2 2 1 2 1 1 1 1 1 1 1 1 1 1 1 1 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + M + M M + + + M + M + + + + + + + + M +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 2 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 85
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 6| 3| 7| 7| 4| 7| 7| 6| 6| 5| 5| 7| 5| 5| 6| 5| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 2| 6| 0| 3| 9| 2| 2| 9| 2| 2| 6| 9| 8| 8| 3| 4| 3| 6| 6| 2| 2|
| 1| 1| 0| 0| 9| 7| 5| 9| 4| 9| 9| 4| 9| 9| 7| 5| 6| 6| 0| 6| 5| 7| 2| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
4.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 2 2 4 3 2 4 1 4 3 3 |
Inflammation | 1 |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 1 4 |
Interstitial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
|__________________________________________________________________________|
Lymph Node | + |
|__________________________________________________________________________|
Lymph Node, Bronchial | + + + + M + M M + + M + + + + + + + + + M + + + +|
Hyperplasia | 2 2 2 2 2 2 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + + M + + + + + + + + M + + + + + + + +|
Hyperplasia | 2 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + M + + + + + + + M M + + + M + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Lymph Node, Mediastinal | + + M + + M M + M + + + + M + + + + + + + + M + M|
Hyperplasia | 2 2 2 2 3 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hematopoietic Cell Proliferation | 2 2 2 2 |
Hyperplasia, Lymphoid | 2 2 2 2 2 2 2 |
Inflammation, Focal, Granulomatous | 1 |
__________________________________________|__________________________________________________________________________|
Page 86
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 6| 3| 7| 7| 4| 7| 7| 6| 6| 5| 5| 7| 5| 5| 6| 5| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 2| 6| 0| 3| 9| 2| 2| 9| 2| 2| 6| 9| 8| 8| 3| 4| 3| 6| 6| 2| 2|
| 1| 1| 0| 0| 9| 7| 5| 9| 4| 9| 9| 4| 9| 9| 7| 5| 6| 6| 0| 6| 5| 7| 2| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
4.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
|__________________________________________________________________________|
Thymus | + + + M + + + + + + + + + + M M M + M M + + + + +|
Epithelial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Prepuce, Inflammation, Chronic Active| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | |
|__________________________________________________________________________|
Skeletal Muscle | + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Respiratory Epithelium, Epiglottis, | |
Metaplasia, Squamous | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Squamous Epithelium, Hyperplasia | 1 1|
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Inflammation, Chronic | 2 2 2 1 1 1 2 2 1 2 2 3 2 2 2 2 2 3 2 2 2 2 3 2|
Alveolar Epithelium, Hyperplasia | 4 4 4 2 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4|
Alveolus, Infiltration Cellular, | |
Histiocyte | 3 2 2 2 4 4 4 3 4 3 2 4 3 3 4 4 1 2 4 2 4 2 4 3 3|
Bronchiole, Epithelium, Hyperplasia | 2 2 2 1 1 2 2 2 2 1 2 1 1 1 2 1 1 2 2 1 2|
Interstitium, Fibrosis | 2 1 1 2 |
__________________________________________|__________________________________________________________________________|
Page 87
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 6| 3| 7| 7| 4| 7| 7| 6| 6| 5| 5| 7| 5| 5| 6| 5| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 2| 6| 0| 3| 9| 2| 2| 9| 2| 2| 6| 9| 8| 8| 3| 4| 3| 6| 6| 2| 2|
| 1| 1| 0| 0| 9| 7| 5| 9| 4| 9| 9| 4| 9| 9| 7| 5| 6| 6| 0| 6| 5| 7| 2| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
4.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 1 2 2 1 3 1 1 2 1|
Lateral Wall, Hyperplasia | |
Lateral Wall, Metaplasia, Squamous | 1 |
Olfactory Epithelium, Atrophy | 1 1 1 1 1 1 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 2 1 1 1 1 1 2 1 1 1 1 1 2 1 1|
Respiratory Epithelium, Degeneration,| |
Hyaline | 2 1 2 2 1 1 1 2 2 1 2 1 3 3 1 1 1 2 1|
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 |
Respiratory Epithelium, Necrosis | 1 |
|__________________________________________________________________________|
Pleura | + |
Mesothelium, Hyperplasia | 2 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Ear | |
Inflammation | |
Internal Ear, Necrosis | |
|__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accumulation, Hyaline Droplet | 2 |
Cyst | 1 1 1 |
Metaplasia, Osseous | |
Nephropathy | 1 1 1 1 1 1 1 1 2 2 1 1 1 1 1 2 1 1 1 1 2 1 2 1 1|
Renal Tubule, Hyperplasia | 1 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 |
__________________________________________|__________________________________________________________________________
Page 88
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 5| 3| 7| 7| 7| 5| 7| 5| 7| 6| 7| 7| |
DAY ON TEST | 5| 8| 3| 4| 5| 7| 3| 3| 3| 2| 3| 3| 2| 7| 8| 2| 3| 2| 4| 2| 9| 3| 7| 2| 3| |
| 4| 2| 0| 5| 3| 0| 0| 0| 0| 9| 0| 0| 9| 3| 7| 9| 0| 9| 1| 9| 0| 0| 6| 9| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
4.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + M M + + + + + + + + + A + + + + + M| 41 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + A + + + + + + + M + + + + + + A + + + + + +| 45 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + A + + + + + + + + + + + + + + A + + + + + +| 47 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + I + A + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Eosinophilic Focus | X X X X X X X X X X| 17 |
Eosinophilic Focus, Multiple | | 2 |
Inflammation, Focal, Granulomatous | 2 | 3 1.3|
Necrosis, Focal | 1 1 | 4 1.3|
Pigmentation, Hemosiderin | 3 | 1 3.0|
Tension Lipidosis | | 3 |
|__________________________________________________________________________|____________|
Mesentery | | 1 |
Fat, Necrosis | | 1 2.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 2 1.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 89
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 5| 3| 7| 7| 7| 5| 7| 5| 7| 6| 7| 7| |
DAY ON TEST | 5| 8| 3| 4| 5| 7| 3| 3| 3| 2| 3| 3| 2| 7| 8| 2| 3| 2| 4| 2| 9| 3| 7| 2| 3| |
| 4| 2| 0| 5| 3| 0| 0| 0| 0| 9| 0| 0| 9| 3| 7| 9| 0| 9| 1| 9| 0| 0| 6| 9| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
4.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Angiectasis | 2 | 1 2.0|
Ulcer | 1 | 1 1.0|
Epithelium, Hyperplasia | 4 1 | 4 2.3|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | | 1 1.0|
Epithelium, Hyperplasia | 2| 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + | 1 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 1 1 1 1 1 2 1 1 1 1 1 3 2 1 2 1 2 1 2 1 1 1| 47 1.2|
Artery, Inflammation | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hypertrophy | 1 2 2 1 1 2 1 2 1 1 1 1 1 1 1| 31 1.2|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 1.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 2 1.0|
|__________________________________________________________________________|____________|
Parathyroid Gland | M M + + M + + M + + M + M + M + + + + + M + + +| 35 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + M + + + + + + + + + + + +| 49 |
Pars Distalis, Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 90
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 5| 3| 7| 7| 7| 5| 7| 5| 7| 6| 7| 7| |
DAY ON TEST | 5| 8| 3| 4| 5| 7| 3| 3| 3| 2| 3| 3| 2| 7| 8| 2| 3| 2| 4| 2| 9| 3| 7| 2| 3| |
| 4| 2| 0| 5| 3| 0| 0| 0| 0| 9| 0| 0| 9| 3| 7| 9| 0| 9| 1| 9| 0| 0| 6| 9| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
4.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma Sperm | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
Ectasia | 3 4 2 2 2 4 3 3 2 | 20 2.8|
Inflammation | 3 2| 3 2.0|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + M + + + + + +| 49 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 4 | 1 4.0|
Epithelium, Hyperplasia | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 2 | 5 2.0|
Interstitial Cell, Hyperplasia | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 2| 4 2.0|
|__________________________________________________________________________|____________|
Lymph Node | | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + M + + + M + + M + M M + + + + + + +| 40 |
Hyperplasia | 3 2 2 2 2 4 2 | 13 2.2|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M + M + + M M M + + M M M M M + M + M + + +| 35 |
Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + M + + + + + + + + + + M + + + + + + + + + + + +| 44 |
Hyperplasia | 2 2 | 2 2.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 91
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 5| 3| 7| 7| 7| 5| 7| 5| 7| 6| 7| 7| |
DAY ON TEST | 5| 8| 3| 4| 5| 7| 3| 3| 3| 2| 3| 3| 2| 7| 8| 2| 3| 2| 4| 2| 9| 3| 7| 2| 3| |
| 4| 2| 0| 5| 3| 0| 0| 0| 0| 9| 0| 0| 9| 3| 7| 9| 0| 9| 1| 9| 0| 0| 6| 9| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
4.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Lymph Node, Mediastinal | + + + + + M M + M + + M M + + + + + + + + + M + +| 37 |
Hyperplasia | 2 | 6 2.2|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 | 1 1.0|
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 | 10 2.0|
Hyperplasia, Lymphoid | 2 2 2| 10 2.0|
Inflammation, Focal, Granulomatous | | 1 1.0|
|__________________________________________________________________________|____________|
Thymus | + M + + M + + M + M + M M + M + M + + + + + + + M| 35 |
Epithelial Cell, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M + M| 1 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 4 | 1 4.0|
Prepuce, Inflammation, Chronic Active| 4 4 | 2 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 1 1 | 2 1.0|
|__________________________________________________________________________|____________|
Skeletal Muscle | + | 3 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 92
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 5| 3| 7| 7| 7| 5| 7| 5| 7| 6| 7| 7| |
DAY ON TEST | 5| 8| 3| 4| 5| 7| 3| 3| 3| 2| 3| 3| 2| 7| 8| 2| 3| 2| 4| 2| 9| 3| 7| 2| 3| |
| 4| 2| 0| 5| 3| 0| 0| 0| 0| 9| 0| 0| 9| 3| 7| 9| 0| 9| 1| 9| 0| 0| 6| 9| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
4.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Respiratory Epithelium, Epiglottis, | | |
Metaplasia, Squamous | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 41 1.0|
Squamous Epithelium, Hyperplasia | 2 1 1 | 5 1.2|
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 2.0|
Inflammation, Chronic | 2 2 2 2 3 2 1 2 3 2 2 2 2 3 1 1 3 2 3 3 2 1 2| 47 2.0|
Alveolar Epithelium, Hyperplasia | 4 2 4 2 4 4 4 4 4 4 4 4 4 4 4 4 4 4 3 4 4 4 4 4 4| 50 3.9|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 4 3 3 4 4 3 2 4 4 2 2 2 4 3 2 3 4 4 4 4 2 3 1 2| 49 3.0|
Bronchiole, Epithelium, Hyperplasia | 2 2 2 2 2 1 2 1 2 1 1 2 2 2 2 2 2 3 1 2 1 2 1 2 2| 46 1.7|
Interstitium, Fibrosis | 2 2 2 1 2 2 2 1 | 12 1.7|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 1 1 1 1 1 1 1 1 2 1 1 1| 23 1.3|
Lateral Wall, Hyperplasia | 1| 1 1.0|
Lateral Wall, Metaplasia, Squamous | | 1 1.0|
Olfactory Epithelium, Atrophy | 1 1 1 2 2 1| 12 1.2|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 1 1 1 1 1 1 2 1 1 1 1 1 2 1| 30 1.2|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 1 1 1 1 1 1 2 2 1 1 2 1 1 1 1 1 1 2 1 1 1 1| 41 1.4|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 1 | 2 1.5|
Respiratory Epithelium, Necrosis | 1 | 2 1.0|
|__________________________________________________________________________|____________|
Pleura | + | 2 |
Mesothelium, Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Ear | + | 1 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 93
NTP Experiment-Test: 61427-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:33:14
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 5| 3| 7| 7| 7| 5| 7| 5| 7| 6| 7| 7| |
DAY ON TEST | 5| 8| 3| 4| 5| 7| 3| 3| 3| 2| 3| 3| 2| 7| 8| 2| 3| 2| 4| 2| 9| 3| 7| 2| 3| |
| 4| 2| 0| 5| 3| 0| 0| 0| 0| 9| 0| 0| 9| 3| 7| 9| 0| 9| 1| 9| 0| 0| 6| 9| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
4.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
Inflammation | 2 | 1 2.0|
Internal Ear, Necrosis | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accumulation, Hyaline Droplet | | 1 2.0|
Cyst | 2 2 2| 6 1.5|
Metaplasia, Osseous | 1 | 1 1.0|
Nephropathy | 2 1 1 1 2 2 2 1 1 1 1 2 2 1 2 1 1 2 1 1 1 1 1| 48 1.3|
Renal Tubule, Hyperplasia | 1 1 1 | 4 1.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 94
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---------- END OF REPORT ----------
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