TDMS Study 61427-08 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest VANADIUM PENTOXIDE DATE: 11/19/01
EXPERIMENT: 61427 TEST: 08 TIME: 10:35:44
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1-ES-55392 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 61427B
PATHOLOGIST: MILLER, RODNEY CAS: 1314-62-1
------------------------------------------------------------------------------------------------------------------------------------
FINAL#2/MICE
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest VANADIUM PENTOXIDE DATE: 11/19/01
EXPERIMENT: 61427 TEST: 08 TIME: 10:35:44
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-55392 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 61427B
PATHOLOGIST: MILLER, RODNEY CAS: 1314-62-1
VANADIUM PENTOXIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 11 CENSORED DEATHS 0 TERMINAL 39 |
| |
| UNCENSORED DEATHS |
| 499 523 603 620 620 667 692 698 701 710 |
| 724 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1.0 MG/M3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 17 CENSORED DEATHS 0 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 405 514 530 534 558 590 614 626 639 639 |
| 666 667 695 714 715 722 728 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 2.0 MG/M3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 14 CENSORED DEATHS 0 TERMINAL 36 |
| |
| UNCENSORED DEATHS |
| 422 534 606 611 617 639 639 653 695 695 |
| 695 709 718 718 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
VANADIUM PENTOXIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 4.0 MG/M3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 23 CENSORED DEATHS 0 TERMINAL 27 |
| |
| UNCENSORED DEATHS |
| 387 394 494 535 541 545 546 562 573 586 |
| 586 590 639 653 654 667 667 667 670 676 |
| 682 695 705 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
VANADIUM PENTOXIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 100.0 100.0 100.0 96.0 94.0 90.0 78.0 |
| | |
| | |
|1.0 | 100.0 100.0 100.0 100.0 98.0 98.0 92.0 88.0 80.0 66.0 |
|MG/M3 | |
| | |
|2.0 | 100.0 100.0 100.0 100.0 98.0 98.0 96.0 96.0 84.0 72.0 |
|MG/M3 | |
| | |
|4.0 | 100.0 100.0 100.0 100.0 96.0 96.0 88.0 76.0 70.0 54.0 |
|MG/M3 | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 1.0 2.0 4.0 |
| MG/M3 MG/M3 MG/M3 |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 78.0% 66.0% 72.0% 54.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.012 P=0.242 P=0.628 P=0.011 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 641.5 620.9 639.4 596.3 |
|NATURAL DEATHS (C) | (23.0) (21.7) (21.9) (18.5) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 709.8 692.3 703.9 667.9 |
|(STANDARD ERROR) | ( 7.1) (10.3) ( 8.3) (12.6) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
VANADIUM PENTOXIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 731 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 12 CENSORED DEATHS 0 TERMINAL 38 |
| |
| UNCENSORED DEATHS |
| 16 181 505 626 642 662 681 683 686 695 |
| 709 715 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1.0 MG/M3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 15 CENSORED DEATHS 3 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 446 522 530 564 584 603 610 635 654 660 |
| 660 668 705 718 726 |
| CENSORED DEATHS |
| 23 23 23 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 2.0 MG/M3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 18 CENSORED DEATHS 2 TERMINAL 30 |
| |
| UNCENSORED DEATHS |
| 270 281 353 416 490 501 534 577 584 639 |
| 646 662 666 695 705 709 709 725 |
| CENSORED DEATHS |
| 251 318 |
| |
==================================================================================
VANADIUM PENTOXIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 731 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 4.0 MG/M3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 18 CENSORED DEATHS 0 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 255 478 542 550 550 565 565 611 612 639 |
| 653 687 695 705 705 725 726 728 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
VANADIUM PENTOXIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 731 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 731 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 98.0 98.0 96.0 96.0 96.0 96.0 94.0 94.0 88.0 76.0 |
| | |
| | |
|1.0 | 100.0 100.0 100.0 100.0 100.0 97.9 93.6 87.2 76.6 68.1 |
|MG/M3 | |
| | |
|2.0 | 100.0 100.0 98.0 93.8 91.7 91.7 85.5 81.3 75.1 62.6 |
|MG/M3 | |
| | |
|4.0 | 100.0 100.0 98.0 98.0 98.0 96.0 94.0 86.0 78.0 64.0 |
|MG/M3 | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 1.0 2.0 4.0 |
| MG/M3 MG/M3 MG/M3 |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 76.0% 68.1% 62.6% 64.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.257 P=0.475 P=0.192 P=0.270 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 566.8 619.0 564.6 610.6 |
|NATURAL DEATHS (C) | (65.9) (20.4) (35.3) (27.6) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 691.6 654.9 653.2 687.7 |
|(STANDARD ERROR) | (18.3) (24.7) (20.0) (12.8) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
VANADIUM PENTOXIDE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
1.0 MG/M3 = 2
2.0 MG/M3 = 3
4.0 MG/M3 = 4
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
104 +
|
| 1 4 2 3 1
| 442 3 1 2 1 3
96 + 4 4 2 123 1
| 4 22 131
P | 24 2 33
E | 2 2 1 3 1
R 88 + 2 2 1 1
C | 4 4 2 2 3 3 11
E | 44 2 2 3 11
N | 4 4 11
T 80 + 2 2 1 1
| 4 4 3 3 1 1
S | 4 4 2 2 33
U | 4 4 2 2
R 72 + 22 3
V | 4 4 22
I |
V | 2 2
A 64 +
L | 44
| 44
| 4 4
56 + 44
| 4 4
|
|
48 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 10 obs hidden.
VANADIUM PENTOXIDE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
1.0 MG/M3 = 2
2.0 MG/M3 = 3
4.0 MG/M3 = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 4 3 2
|
| 1 1 4 3 3 2 4 2
| 1 3 3 4 1 22 4
95 +
| 3 3 1 2 44 2 1
| 1 1
| 3 3 2 2
P 90 + 3 3 4 4 1 1
E | 2 2
R | 3 3 22 1 1
C | 4 4
E 85 + 3 3 2 2
N | 33
T | 4 24 2 1 1
| 3 3 2 2
S 80 + 4 4 1 1
U | 33
R | 34 3 4 11
V | 22 44 1 1
I 75 + 32 2
V | 44
A | 3 32 2
L | 33
70 + 4 22
| 33
| 2 2
|
65 + 3 3
| 4 4
| 3 3
|
60 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 5 obs hidden.