TDMS Study 88007-06 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus SODIUM NITRITE DATE: 05/13/99
EXPERIMENT: 88007 TEST: 06 TIME: 09:45:58
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1-ES-55384 ROUTE: DOSED WATER NTP C#: C88007
PATHOLOGIST: TOFT, JOHN CAS: 7632-00-0
------------------------------------------------------------------------------------------------------------------------------------
2 YEAR CHRONIC MICE
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus SODIUM NITRITE DATE: 05/13/99
EXPERIMENT: 88007 TEST: 06 TIME: 09:45:58
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-55384 ROUTE: DOSED WATER NTP C#: C88007
PATHOLOGIST: TOFT, JOHN CAS: 7632-00-0
SODIUM NITRITE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 727 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0.0% |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 11 CENSORED DEATHS 0 TERMINAL 39 |
| |
| UNCENSORED DEATHS |
| 501 526 617 643 647 652 661 687 701 705 |
| 713 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.075% |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 5 CENSORED DEATHS 0 TERMINAL 45 |
| |
| UNCENSORED DEATHS |
| 444 601 612 637 644 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.15% |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 8 CENSORED DEATHS 0 TERMINAL 42 |
| |
| UNCENSORED DEATHS |
| 577 596 641 643 643 664 667 707 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
SODIUM NITRITE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 727 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0.30% |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 11 CENSORED DEATHS 0 TERMINAL 39 |
| |
| UNCENSORED DEATHS |
| 472 502 549 556 583 594 629 654 665 685 |
| 698 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
SODIUM NITRITE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 727 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 727 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0.0% | 100.0 100.0 100.0 100.0 100.0 100.0 96.0 96.0 86.0 78.0 |
| | |
| | |
|0.075% | 100.0 100.0 100.0 100.0 100.0 98.0 98.0 96.0 90.0 90.0 |
| | |
| | |
|0.15% | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 96.0 88.0 84.0 |
| | |
| | |
|0.30% | 100.0 100.0 100.0 100.0 100.0 98.0 96.0 88.0 82.0 78.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0.0% 0.075% 0.15% 0.30% |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 78.0% 90.0% 84.0% 78.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.659 P=0.199N P=0.616N P=1.000 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 641.2 587.6 642.3 598.8 |
|NATURAL DEATHS (C) | (21.1) (36.8) (14.4) (22.5) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 708.1 713.1 713.4 698.8 |
|(STANDARD ERROR) | ( 6.8) ( 6.8) ( 4.9) ( 9.0) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
SODIUM NITRITE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 728 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0.0% |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 10 CENSORED DEATHS 0 TERMINAL 40 |
| |
| UNCENSORED DEATHS |
| 456 547 565 580 586 615 622 631 663 716 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.075% |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 16 CENSORED DEATHS 0 TERMINAL 34 |
| |
| UNCENSORED DEATHS |
| 484 605 643 650 651 651 652 659 659 664 |
| 667 673 673 683 706 709 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.15% |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 13 CENSORED DEATHS 0 TERMINAL 37 |
| |
| UNCENSORED DEATHS |
| 477 524 610 617 621 677 687 691 706 716 |
| 716 723 726 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
SODIUM NITRITE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 728 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0.30% |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 9 CENSORED DEATHS 0 TERMINAL 41 |
| |
| UNCENSORED DEATHS |
| 401 484 520 567 659 673 687 705 708 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
SODIUM NITRITE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 728 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 728 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0.0% | 100.0 100.0 100.0 100.0 100.0 98.0 98.0 90.0 82.0 80.0 |
| | |
| | |
|0.075% | 100.0 100.0 100.0 100.0 100.0 98.0 98.0 96.0 80.0 68.0 |
| | |
| | |
|0.15% | 100.0 100.0 100.0 100.0 100.0 98.0 96.0 96.0 90.0 74.0 |
| | |
| | |
|0.30% | 100.0 100.0 100.0 100.0 98.0 96.0 94.0 92.0 90.0 82.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0.0% 0.075% 0.15% 0.30% |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 80.0% 68.0% 74.0% 82.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.537N P=0.340 P=0.721 P=0.963N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 598.1 651.8 653.2 600.4 |
|NATURAL DEATHS (C) | (22.2) (12.7) (22.1) (37.2) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 702.0 703.6 708.5 705.0 |
|(STANDARD ERROR) | ( 8.6) ( 6.5) ( 7.3) ( 9.5) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
SODIUM NITRITE
KAPLAN-MEIER SURVIVAL CURVES
0.0% = 1
0.075% = 2
0.15% = 3
0.30% = 4
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 4 1 3
|
| 2 4 1 1 3 2
|
P 96 + 4 1 4 2 21 3
E |
R | 44 21 21
C |
E 92 + 4 4 211
N |
T | 44 2113 2
|
S 88 + 4 4 113
U |
R | 4 413 1 3
V |
I 84 + 44 1 1 3
V |
A | 4 4
L |
80 + 4 411
|
| 4 1 1
|
76 +
|
---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+--
0 4 8 12 16 20 24 28 32 36 40 44 48 52 56 60 64 68 72 76 80 84 88 92 96 100 104
WEEK
NOTE: 11 obs hidden.
SODIUM NITRITE
KAPLAN-MEIER SURVIVAL CURVES
0.0% = 1
0.075% = 2
0.15% = 3
0.30% = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 4 1 32
|
| 4 1 32 3 1 2
| 4 3 1 1 23 2
95 +
| 4 1 1 33 22
P | 4 11 4
E |
R 90 + 1 13 4 3
C |
E | 11 22 3 3
N | 1 1 2 2 4 4
T 85 +
| 1 1 3 34
S | 1 3414
U |
R 80 + 22 11
V |
I | 22 33
V |
A 75 +
L | 22 3
| 2 2
|
70 + 22
|
| 2 2
|
65 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 11 obs hidden.