TDMS Study 88031-05 Pathology Tables
NTP FEED, WATER, AND COMPOUND CONSUMPTION TABLE REPORT: EISRPT39
LAB: Battelle Columbus DIPROPYLENE GLYCOL DATE: 12/07/00
EXPERIMENT: 88031 TEST: 05 TIME: 10:26:17
CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: DOSED WATER NTP: C88031
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP FEED, WATER, AND COMPOUND CONSUMPTION TABLE REPORT: EISRPT39
LAB: BATTELLE COLUMBUS DIPROPYLENE GLYCOL DATE: 12/07/00
EXPERIMENT: 88031 TEST: 05 TIME: 10:41:50
TEST TYPE: CHRONIC ROUTE: DOSED WATER NTP: C88031
CONT: N01-ES-55388 CAS: 25265-71-8
WATER AND COMPOUND CONSUMPTION BY MALE RATS IN THE
CHRONIC DOSED WATER STUDY OF DIPROPYLENE GLYCOL
==================================================================================================================================
0.0% 0.25% 1.0% 4.0%
---------------- --------------------------------- --------------------------------- ---------------------------------
DOSE/ DOSE/ DOSE/
GRAMS BODY GRAMS BODY CONTROL GRAMS BODY CONTROL GRAMS BODY CONTROL
WATER/ WEIGHT WATER/ WEIGHT WATER (B) DOSE/ WATER/ WEIGHT WATER (B) DOSE/ WATER/ WEIGHT WATER (B) DOSE/
WEEK DAY(A) (GRAMS) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C)
==================================================================================================================================
1 16.2 99.8 16.3 100.4 1.01 406 15.9 100.2 0.98 1588 9.4 101.7 0.58 3680
2 16.4 132.7 16.5 132.6 1.01 311 16.8 132.5 1.02 1269 15.7 122.1 0.96 5155
6 19.8 251.7 19.1 248.1 0.96 192 20.4 247.1 1.03 824 21.2 230.5 1.07 3684
10 17.9 316.3 17.5 311.0 0.98 141 18.7 307.9 1.04 608 19.0 282.0 1.06 2696
14 17.5 360.1 17.4 350.2 0.99 124 17.4 344.4 0.99 506 17.5 309.1 1.00 2263
18 18.3 394.6 17.7 386.1 0.97 114 17.2 375.4 0.94 457 18.9 339.7 1.03 2227
22 19.1 420.1 18.6 412.2 0.97 113 18.6 400.2 0.97 466 21.2 362.9 1.11 2339
26 19.3 432.3 19.2 426.4 0.99 112 17.9 412.0 0.93 436 21.9 375.2 1.13 2338
30 18.6 449.9 18.6 442.6 1.00 105 18.7 426.2 1.01 439 21.8 388.0 1.17 2249
34 18.1 464.1 19.3 455.4 1.07 106 19.0 440.9 1.05 432 22.6 398.6 1.25 2267
38 17.0 471.4 17.1 468.1 1.01 91 16.4 451.3 0.96 363 20.9 406.4 1.23 2057
42 17.7 484.3 17.7 482.9 1.00 92 18.1 466.8 1.02 387 22.6 416.2 1.28 2177
46 16.5 489.1 17.2 488.5 1.04 88 17.4 470.8 1.05 370 21.9 418.0 1.33 2100
50 17.4 497.5 17.6 494.5 1.01 89 18.3 477.8 1.05 384 27.0 419.2 1.55 2576
54 17.9 503.6 17.7 502.2 0.99 88 18.2 485.2 1.02 376 28.7 426.5 1.60 2690
58 16.4 511.8 17.0 510.6 1.04 83 16.9 495.3 1.03 342 26.9 424.0 1.64 2537
62 17.6 518.3 17.8 517.4 1.01 86 18.0 501.4 1.02 359 30.1 424.6 1.71 2836
66 16.9 509.7 17.4 511.3 1.03 85 17.8 494.9 1.05 359 31.0 415.6 1.83 2980
70 17.2 513.5 16.8 514.7 0.98 82 17.1 499.9 0.99 342 29.3 408.0 1.70 2877
74 16.4 513.3 16.1 520.7 0.98 77 16.9 501.0 1.03 338 35.0 404.3 2.13 3465
78 16.5 510.9 16.1 514.1 0.98 79 16.1 493.4 0.98 327 36.3 395.4 2.20 3671
82 16.9 511.3 16.5 512.6 0.98 80 16.3 495.1 0.96 329 34.6 386.7 2.05 3583
86 16.7 514.4 16.9 512.9 1.01 83 17.2 489.9 1.03 352 37.7 370.9 2.26 4061
90 17.2 511.8 17.4 513.5 1.01 85 16.9 493.6 0.98 343 29.9 350.5 1.74 3409
94 16.0 509.2 16.7 516.6 1.04 81 16.8 495.9 1.05 339 43.0 367.1 2.69 4685
98 18.5 519.6 18.0 514.4 0.97 88 17.9 486.0 0.97 369 35.9 330.9 1.94 4340
102 18.1 513.3 16.2 506.4 0.90 80 18.7 489.0 1.03 382
1 TO 13 WEEKS
----------------
MEAN 17.6 200.1 17.3 198.0 0.99 263 18.0 196.9 1.02 1072 16.3 184.1 0.92 3804
SD(D) 1.7 1.3 0.02 119 2.0 0.03 440 5.2 0.23 1014
CV(E) 9.5 7.3 2.1 45.5 11.1 2.7 41.1 31.6 25.1 26.7
14 TO 52 WEEKS
----------------
MEAN 17.9 446.4 18.0 440.7 1.01 103 17.9 426.6 1.00 424 21.6 383.3 1.21 2259
SD(D) 0.9 0.8 0.03 13 0.8 0.05 47 2.5 0.16 144
CV(E) 5.1 4.5 2.9 12.4 4.6 4.7 11.0 11.6 13.2 6.4
> 52 WEEKS
----------------
MEAN 17.1 512.4 17.0 512.9 0.99 83 17.3 493.9 1.01 350 33.2 392.0 1.96 3428
SD(D) 0.8 0.6 0.04 3 0.8 0.03 17 4.7 0.32 680
CV(E) 4.4 3.8 3.9 4.1 4.4 3.1 5.0 14.0 16.4 19.8
==================================================================================================================================
(A) GRAMS OF WATER CONSUMED PER ANIMAL PER DAY.
(B) GRAMS OF WATER PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.
(D) STANDARD DEVIATION OF WEEKLY MEAN.
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.
WATER AND COMPOUND CONSUMPTION BY FEMALE RATS IN THE
CHRONIC DOSED WATER STUDY OF DIPROPYLENE GLYCOL
==================================================================================================================================
0.0% 0.25% 1.0% 4.0%
---------------- --------------------------------- --------------------------------- ---------------------------------
DOSE/ DOSE/ DOSE/
GRAMS BODY GRAMS BODY CONTROL GRAMS BODY CONTROL GRAMS BODY CONTROL
WATER/ WEIGHT WATER/ WEIGHT WATER (B) DOSE/ WATER/ WEIGHT WATER (B) DOSE/ WATER/ WEIGHT WATER (B) DOSE/
WEEK DAY(A) (GRAMS) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C)
==================================================================================================================================
1 14.2 93.8 14.3 93.9 1.01 380 13.8 92.8 0.97 1490 8.3 92.5 0.58 3570
2 13.2 111.6 13.5 112.3 1.02 300 13.2 111.9 1.00 1182 12.2 105.0 0.92 4635
6 14.4 161.8 14.3 160.8 0.99 222 13.9 160.2 0.97 866 12.9 152.0 0.90 3392
10 13.2 184.0 14.0 180.5 1.06 194 12.9 180.3 0.98 718 11.6 165.2 0.88 2817
14 12.6 195.4 12.6 194.4 1.00 163 11.2 193.4 0.89 580 10.9 178.8 0.87 2431
18 12.9 208.9 12.6 206.0 0.98 153 11.7 204.0 0.91 575 11.1 187.2 0.86 2382
22 13.1 218.2 12.9 215.7 0.98 150 12.6 214.8 0.96 586 11.5 195.7 0.88 2343
26 13.1 222.1 12.7 219.4 0.97 145 11.9 219.3 0.91 542 11.2 198.5 0.85 2263
30 12.7 232.0 12.5 227.9 0.98 137 11.9 227.2 0.94 522 12.1 203.4 0.95 2383
34 13.1 240.7 13.6 235.2 1.04 145 13.3 236.2 1.02 564 13.3 208.4 1.02 2557
38 11.9 244.6 12.2 243.6 1.03 126 12.0 244.8 1.01 489 12.5 213.8 1.05 2339
42 12.2 253.6 12.3 252.0 1.01 122 12.0 254.5 0.98 472 12.5 218.4 1.02 2299
46 12.5 267.0 12.5 263.8 1.00 119 12.4 262.7 0.99 473 12.6 224.3 1.01 2238
50 13.6 279.4 13.7 274.9 1.01 125 12.9 274.9 0.95 469 13.1 230.5 0.96 2277
54 12.2 288.3 12.9 283.4 1.06 114 12.4 284.9 1.02 437 13.6 243.5 1.11 2231
58 12.0 298.5 12.4 292.8 1.03 106 12.0 294.6 1.00 406 13.2 251.0 1.10 2105
62 11.8 306.5 11.8 297.9 1.00 99 11.8 304.5 1.00 389 12.6 259.5 1.07 1938
66 12.4 312.7 12.7 303.0 1.02 105 12.6 310.0 1.02 405 13.1 262.7 1.06 1996
70 12.9 319.7 13.6 310.9 1.05 109 12.6 316.5 0.98 398 13.9 271.4 1.08 2043
74 11.8 327.6 12.8 319.7 1.08 100 12.2 324.3 1.03 375 13.3 277.6 1.13 1917
78 11.7 328.2 12.7 315.2 1.09 101 12.4 325.3 1.06 381 13.7 274.3 1.17 2002
82 12.5 337.4 12.5 321.1 1.00 98 13.1 328.3 1.05 398 13.1 285.0 1.05 1840
86 12.7 337.2 13.8 325.1 1.09 106 13.1 331.5 1.03 396 13.8 289.2 1.09 1916
90 13.2 342.0 12.9 328.3 0.98 99 13.4 335.6 1.02 400 14.5 288.2 1.10 2011
94 13.7 348.0 13.8 335.0 1.01 103 13.3 342.0 0.97 389 14.6 296.6 1.07 1963
98 13.8 350.8 14.5 338.7 1.05 107 14.1 347.8 1.02 406 15.1 295.2 1.09 2049
102 14.4 350.5 14.8 346.6 1.03 107 13.7 352.1 0.95 390 14.3 301.3 0.99 1896
1 TO 13 WEEKS
----------------
MEAN 13.8 137.8 14.0 136.9 1.02 274 13.5 136.3 0.98 1064 11.2 128.7 0.82 3603
SD(D) 0.6 0.4 0.03 83 0.5 0.02 343 2.1 0.16 759
CV(E) 4.6 2.7 2.9 30.5 3.4 1.5 32.3 18.3 19.3 21.1
14 TO 52 WEEKS
----------------
MEAN 12.8 236.2 12.8 233.3 1.00 138 12.2 233.2 0.96 527 12.1 205.9 0.95 2351
SD(D) 0.5 0.5 0.02 15 0.6 0.04 48 0.9 0.08 94
CV(E) 4.0 4.0 2.2 10.8 5.1 4.7 9.2 7.1 8.1 4.0
> 52 WEEKS
----------------
MEAN 12.7 326.7 13.2 316.7 1.04 104 12.8 322.9 1.01 398 13.8 276.6 1.08 1993
SD(D) 0.9 0.9 0.04 5 0.7 0.03 15 0.7 0.04 102
CV(E) 6.9 6.5 3.5 4.6 5.5 3.1 3.8 5.2 3.9 5.1
==================================================================================================================================
(A) GRAMS OF WATER CONSUMED PER ANIMAL PER DAY.
(B) GRAMS OF WATER PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.
(D) STANDARD DEVIATION OF WEEKLY MEAN.
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.
DIAGNOSTIC TRAILER REPORT
WATER AND COMPOUND CONSUMPTION BY MALE RATS IN THE
CHRONIC DOSED WATER STUDY OF DIPROPYLENE GLYCOL
=========================================================================================================
0.0% 0.25% 1.0% 4.0%
---------------------- ---------------------- ---------------------- ----------------------
DAILY WATER BODY NUM DAILY WATER BODY NUM DAILY WATER BODY NUM DAILY WATER BODY NUM
WEEK WATER HOURS WGT WGTS WATER HOURS WGT WGTS WATER HOURS WGT WGTS WATER HOURS WGT WGTS
==========================================================================================================
B 99.8 50 100.4 50 100.2 50 101.7 50
1 16.2 3367 99.8 50 16.3 3367 100.4 50 15.9 3305 100.2 50 9.4 3366 101.7 50
2 16.4 4880 132.7 50 16.5 4884 132.6 50 16.8 4929 132.5 50 15.7 4859 122.1 50
5 19.1 3493 18.9 3558 20.4 3522 22.5 845
6 19.8 4739 251.7 50 19.1 4802 248.1 50 20.4 4787 247.1 50 21.2 2792 230.5 50
9 18.9 3365 18.6 3390 19.0 3206 18.9 3494
10 17.9 4882 316.3 50 17.5 4606 311.0 50 18.7 4799 307.9 50 19.0 4739 282.0 50
13 17.6 3513 17.4 3451 17.3 3535 17.4 3497
14 17.5 4869 360.1 50 17.4 4913 350.2 50 17.4 4931 344.4 50 17.5 5001 309.1 50
17 16.6 3622 16.9 3588 16.8 3539 18.0 3135
18 18.3 4434 394.6 50 17.7 4836 386.1 50 17.2 4904 375.4 50 18.9 4894 339.7 50
21 18.5 3371 17.7 3612 17.9 3596 20.3 3608
22 19.1 4823 420.1 50 18.6 4834 412.2 50 18.6 4842 400.2 50 21.2 3891 362.9 50
25 20.3 3400 19.8 3609 18.0 3591 21.7 2979
26 19.3 4855 432.3 50 19.2 4859 426.4 50 17.9 4882 412.0 50 21.9 4826 375.2 50
29 17.9 3518 17.5 3524 18.0 3524 21.3 3391
30 18.6 4710 449.9 50 18.6 4690 442.6 50 18.7 4701 426.2 50 21.8 4105 388.0 50
33 17.5 3633 18.6 3639 18.3 3641 22.6 2551
34 18.1 4762 464.1 50 19.3 4795 455.4 50 19.0 4809 440.9 50 22.6 2204 398.6 50
37 17.4 3616 17.4 3617 17.2 3612 21.6 2752
38 17.0 4901 471.4 50 17.1 4891 468.1 50 16.4 4921 451.3 50 20.9 3763 406.4 50
41 17.2 3538 16.9 3631 17.2 3662 22.0 2939
42 17.7 4381 484.3 49 17.7 4753 482.9 50 18.1 4733 466.8 50 22.6 3077 416.2 50
45 15.5 3527 15.3 3836 15.7 3845 21.8 3599
46 16.5 4550 489.1 49 17.2 4655 488.5 50 17.4 4477 470.8 50 21.9 3043 418.0 50
49 16.7 3566 16.7 3734 17.1 3694 23.3 1472
50 17.4 4528 497.5 48 17.6 4708 494.5 50 18.3 4667 477.8 49 27.0 3785 419.2 50
53 17.1 3274 17.4 3432 18.2 3368 27.9 2261
54 17.9 4649 503.6 48 17.7 4871 502.2 50 18.2 4771 485.2 49 28.7 4846 426.5 50
57 16.9 3369 16.9 3593 17.6 3524 27.9 3589
58 16.4 4557 511.8 47 17.0 4811 510.6 50 16.9 4697 495.3 49 26.9 4787 424.0 49
61 16.6 3391 17.4 3735 17.5 3541 30.5 5728
62 17.6 4247 518.3 47 17.8 4027 517.4 49 18.0 4205 501.4 49 30.1 2019 424.6 48
65 16.9 3193 17.2 3223 17.1 3360 31.8 3115
66 16.9 4547 509.7 47 17.4 4770 511.3 48 17.8 4550 494.9 49 31.0 4331 415.6 45
69 18.5 3169 19.0 3247 18.8 3332 34.6 3043
70 17.2 4213 513.5 47 16.8 4652 514.7 48 17.1 4750 499.9 49 29.3 4323 408.0 42
73 17.3 3238 17.0 3256 17.0 3446 37.2 2706
74 16.4 4514 513.3 46 16.1 4561 520.7 47 16.9 4731 501.0 49 35.0 2859 404.3 39
77 16.4 3456 15.3 3262 16.7 3703 38.1 3634
78 16.5 4525 510.9 46 16.1 4478 514.1 46 16.1 4788 493.4 49 36.3 2617 395.4 36
81 16.1 3335 16.8 3106 16.3 3367 34.0 2411
82 16.9 2865 511.3 42 16.5 4013 512.6 42 16.3 4390 495.1 46 34.6 2749 386.7 29
85 17.2 2862 16.9 2974 17.4 3128 40.6 1740
86 16.7 3687 514.4 39 16.9 3862 512.9 41 17.2 4041 489.9 43 37.7 2266 370.9 23
89 16.5 2612 17.7 2741 16.4 2938 33.8 980
90 17.2 3730 511.8 39 17.4 3796 513.5 40 16.9 3838 493.6 39 29.9 1232 350.5 12
93 16.5 2608 17.1 2756 16.8 2610 43.6 288
94 16.0 3487 509.2 37 16.7 3675 516.6 38 16.8 3280 495.9 34 43.0 380 367.1 4
97 17.6 2235 18.1 2605 18.8 2193 42.7 141
=========================================================================================================
DIAGNOSTIC TRAILER REPORT
WATER AND COMPOUND CONSUMPTION BY MALE RATS IN THE
CHRONIC DOSED WATER STUDY OF DIPROPYLENE GLYCOL
=========================================================================================================
0.0% 0.25% 1.0% 4.0%
---------------------- ---------------------- ---------------------- ----------------------
DAILY WATER BODY NUM DAILY WATER BODY NUM DAILY WATER BODY NUM DAILY WATER BODY NUM
WEEK WATER HOURS WGT WGTS WATER HOURS WGT WGTS WATER HOURS WGT WGTS WATER HOURS WGT WGTS
==========================================================================================================
98 18.5 2909 519.6 30 18.0 3594 514.4 36 17.9 3217 486.0 33 35.9 196 330.9 2
101 18.6 1728 17.7 2365 20.0 2159
102 18.1 2421 513.3 25 16.2 3013 506.4 34 18.7 3027 489.0 31
MEAN BODY WGT FOR WEEKS
1 TO 13 200.1 198.0 196.9 184.1
14 TO 52 446.4 440.7 426.6 383.3
> 52 512.4 512.9 493.9 392.0
=========================================================================================================
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
DIAGNOSTIC TRAILER REPORT
WATER AND COMPOUND CONSUMPTION BY FEMALE RATS IN THE
CHRONIC DOSED WATER STUDY OF DIPROPYLENE GLYCOL
=========================================================================================================
0.0% 0.25% 1.0% 4.0%
---------------------- ---------------------- ---------------------- ----------------------
DAILY WATER BODY NUM DAILY WATER BODY NUM DAILY WATER BODY NUM DAILY WATER BODY NUM
WEEK WATER HOURS WGT WGTS WATER HOURS WGT WGTS WATER HOURS WGT WGTS WATER HOURS WGT WGTS
==========================================================================================================
B 93.8 50 93.9 50 92.8 50 92.5 50
1 14.2 3380 93.8 50 14.3 3390 93.9 50 13.8 3390 92.8 50 8.3 3380 92.5 50
2 13.2 4799 111.6 50 13.5 4824 112.3 50 13.2 4839 111.9 50 12.2 4827 105.0 50
5 14.0 2910 14.0 3273 13.6 3156 12.4 3580
6 14.4 2867 161.8 50 14.3 4346 160.8 50 13.9 4858 160.2 50 12.9 4814 152.0 50
9 14.2 3246 13.1 3240 13.0 3605 12.9 3610
10 13.2 4865 184.0 50 14.0 4359 180.5 50 12.9 4541 180.3 50 11.6 4380 165.2 50
13 12.9 3520 12.7 3168 11.8 3541 10.6 3480
14 12.6 4864 195.4 50 12.6 4881 194.4 50 11.2 4868 193.4 50 10.9 4946 178.8 50
17 12.9 3591 13.4 2852 11.5 3522 11.0 3540
18 12.9 4894 208.9 50 12.6 4931 206.0 50 11.7 4985 204.0 50 11.1 4980 187.2 50
21 12.9 3591 12.5 3590 12.1 3590 11.3 3600
22 13.1 4804 218.2 50 12.9 4826 215.7 50 12.6 4844 214.8 50 11.5 4806 195.7 50
25 13.1 3576 12.7 3571 11.7 3570 11.4 3571
26 13.1 4817 222.1 50 12.7 4826 219.4 50 11.9 4850 219.3 50 11.2 4831 198.5 50
29 12.6 3518 11.5 3561 10.6 3600 11.7 3561
30 12.7 4778 232.0 50 12.5 4310 227.9 50 11.9 4793 227.2 50 12.1 4794 203.4 50
33 13.0 3640 12.9 3276 12.8 3640 12.8 3640
34 13.1 4755 240.7 50 13.6 4770 235.2 50 13.3 4783 236.2 50 13.3 4769 208.4 50
37 11.2 3138 13.0 3569 12.6 3574 13.7 3197
38 11.9 4706 244.6 49 12.2 4845 243.6 50 12.0 4858 244.8 50 12.5 4900 213.8 50
41 12.9 3288 12.8 3363 12.8 3370 13.1 3348
42 12.2 4316 253.6 49 12.3 4911 252.0 50 12.0 4925 254.5 50 12.5 4905 218.4 50
45 12.2 3689 11.8 3756 12.3 3675 12.6 3771
46 12.5 4251 267.0 49 12.5 4607 263.8 50 12.4 4668 262.7 49 12.6 4733 224.3 50
49 12.2 3688 12.4 3749 11.8 3670 12.6 3740
50 13.6 4463 279.4 49 13.7 4575 274.9 50 12.9 4608 274.9 49 13.1 4796 230.5 50
53 13.6 3406 13.7 3474 13.2 3410 14.1 3501
54 12.2 4694 288.3 49 12.9 4811 283.4 50 12.4 4721 284.9 49 13.6 4781 243.5 50
57 11.8 3705 12.0 3774 11.7 3696 12.9 3780
58 12.0 4108 298.5 49 12.4 4702 292.8 50 12.0 4630 294.6 49 13.2 4699 251.0 50
61 12.2 3537 12.3 3606 12.0 3602 13.2 3695
62 11.8 4664 306.5 48 11.8 4697 297.9 48 11.8 4786 304.5 49 12.6 4897 259.5 50
65 12.8 3301 13.1 3209 12.8 3327 13.3 3064
66 12.4 4716 312.7 48 12.7 4680 303.0 47 12.6 4920 310.0 49 13.1 4966 262.7 50
69 12.6 3221 14.3 3168 13.2 3292 14.8 3360
70 12.9 4677 319.7 48 13.6 4589 310.9 47 12.6 4803 316.5 49 13.9 4960 271.4 50
73 13.3 3253 14.3 3170 13.6 3305 14.4 3370
74 11.8 4738 327.6 48 12.8 4634 319.7 47 12.2 4864 324.3 49 13.3 4895 277.6 50
77 11.9 3433 13.0 3421 13.0 3254 13.9 3179
78 11.7 4493 328.2 46 12.7 4532 315.2 47 12.4 4232 325.3 49 13.7 4615 274.3 48
81 13.7 3022 13.6 3132 14.0 3322 14.1 3209
82 12.5 4359 337.4 44 12.5 4598 321.1 46 13.1 4925 328.3 49 13.1 4591 285.0 46
85 13.2 3153 13.8 3086 12.3 3522 13.5 3155
86 12.7 3774 337.2 44 13.8 4078 325.1 43 13.1 4687 331.5 49 13.8 4131 289.2 44
89 13.7 3139 13.5 3126 13.0 3255 13.8 3055
90 13.2 4050 342.0 42 12.9 4073 328.3 41 13.4 4313 335.6 45 14.5 4043 288.2 42
93 13.5 2851 14.3 2709 13.4 3067 14.6 2497
94 13.7 3817 348.0 40 13.8 3647 335.0 38 13.3 4151 342.0 43 14.6 3823 296.6 39
97 13.9 2225 14.9 2672 13.8 2971 15.3 2670
=========================================================================================================
DIAGNOSTIC TRAILER REPORT
WATER AND COMPOUND CONSUMPTION BY FEMALE RATS IN THE
CHRONIC DOSED WATER STUDY OF DIPROPYLENE GLYCOL
=========================================================================================================
0.0% 0.25% 1.0% 4.0%
---------------------- ---------------------- ---------------------- ----------------------
DAILY WATER BODY NUM DAILY WATER BODY NUM DAILY WATER BODY NUM DAILY WATER BODY NUM
WEEK WATER HOURS WGT WGTS WATER HOURS WGT WGTS WATER HOURS WGT WGTS WATER HOURS WGT WGTS
==========================================================================================================
98 13.8 2934 350.8 39 14.5 3233 338.7 36 14.1 3938 347.8 41 15.1 3594 295.2 37
101 14.6 2127 15.1 2471 14.3 2833 14.0 1834
102 14.4 2873 350.5 33 14.8 3365 346.6 35 13.7 3854 352.1 40 14.3 2882 301.3 34
MEAN BODY WGT FOR WEEKS
1 TO 13 137.8 136.9 136.3 128.7
14 TO 52 236.2 233.3 233.2 205.9
> 52 326.7 316.7 322.9 276.6
=========================================================================================================
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.