TDMS Study 88031-05 Pathology Tables
NTP Experiment-Test: 88031-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:20:44
FINAL#3
Facility: Battelle Columbus Laboratory
Chemical CAS #: 25265-71-8
Lock Date: 11/09/99
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 88031-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:20:44
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.0% 0.25% 1.0% 4.0%
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Natural Death 9 10 6 6
Moribund Sacrifice 11 9 6 12
Accidently Killed 1
Survivors
Terminal Sacrifice 30 31 37 31
Natural Death 1
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (48) (47) (48) (46)
Parasite Metazoan 4 (8%) 4 (9%) 1 (2%) 2 (4%)
Intestine Large, Rectum (48) (47) (49) (46)
Parasite Metazoan 7 (15%) 5 (11%) 13 (27%) 3 (7%)
Intestine Small, Ileum (44) (41) (47) (45)
Necrosis 1 (2%)
Liver (50) (50) (50) (49)
Angiectasis 2 (4%)
Basophilic Focus 46 (92%) 46 (92%) 49 (98%) 46 (94%)
Clear Cell Focus 10 (20%) 16 (32%) 20 (40%) 17 (35%)
Eosinophilic Focus 1 (2%) 4 (8%)
Fatty Change 6 (12%) 9 (18%) 6 (12%) 4 (8%)
Hepatodiaphragmatic Nodule 4 (8%) 7 (14%) 6 (12%) 6 (12%)
Inflammation, Focal, Granulomatous 30 (60%) 33 (66%) 37 (74%) 26 (53%)
Inflammation, Focal, Histiocytic 39 (78%) 37 (74%) 36 (72%) 28 (57%)
Mixed Cell Focus 1 (2%) 7 (14%) 7 (14%) 4 (8%)
Necrosis 1 (2%)
Tension Lipidosis 1 (2%)
Bile Duct, Hyperplasia 2 (4%) 3 (6%) 7 (14%) 18 (37%)
Centrilobular, Necrosis 6 (12%) 8 (16%) 2 (4%) 6 (12%)
Mesentery (15) (13) (13) (11)
Fat, Hemorrhage 1 (8%)
Fat, Necrosis 14 (93%) 13 (100%) 11 (85%) 8 (73%)
Pancreas (47) (48) (48) (48)
Atrophy 7 (15%) 10 (21%) 6 (13%) 10 (21%)
Basophilic Focus 3 (6%) 2 (4%) 3 (6%) 3 (6%)
Hyperplasia 2 (4%) 1 (2%) 4 (8%) 3 (6%)
Salivary Glands (49) (50) (50) (50)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 88031-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:20:44
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.0% 0.25% 1.0% 4.0%
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Atrophy 3 (6%) 4 (8%) 3 (6%) 1 (2%)
Basophilic Focus 1 (2%) 3 (6%) 5 (10%)
Inflammation, Suppurative 1 (2%) 1 (2%) 1 (2%)
Stomach, Forestomach (50) (49) (50) (48)
Foreign Body 1 (2%)
Hyperplasia, Squamous 4 (8%) 3 (6%) 3 (6%) 2 (4%)
Inflammation, Granulomatous 1 (2%)
Ulcer 2 (4%) 6 (12%) 2 (4%) 1 (2%)
Stomach, Glandular (49) (47) (49) (47)
Hypertrophy, Focal 1 (2%)
Inflammation, Chronic 1 (2%)
Mineralization 1 (2%) 1 (2%) 1 (2%)
Necrosis 3 (6%) 2 (4%) 2 (4%) 4 (9%)
Neuroendocrine Cell, Hyperplasia 1 (2%)
Tooth (6) (2) (1) (1)
Inflammation, Chronic Active 6 (100%) 2 (100%) 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Cardiomyopathy 33 (66%) 42 (84%) 32 (64%) 26 (52%)
Atrium, Thrombosis 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (49) (47) (47) (47)
Angiectasis 1 (2%) 1 (2%)
Atrophy 1 (2%)
Degeneration, Cystic 5 (10%) 2 (4%)
Hyperplasia 18 (37%) 24 (51%) 25 (53%) 13 (28%)
Hypertrophy 11 (22%) 14 (30%) 12 (26%) 9 (19%)
Necrosis 1 (2%) 2 (4%) 2 (4%)
Thrombosis 1 (2%)
Adrenal Medulla (49) (47) (46) (47)
Hyperplasia 12 (24%) 8 (17%) 10 (22%) 7 (15%)
Necrosis 2 (4%)
Parathyroid Gland (49) (47) (47) (49)
Hyperplasia 2 (4%)
Pituitary Gland (48) (45) (50) (47)
Angiectasis 3 (6%) 2 (4%)
Cyst 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 88031-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:20:44
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.0% 0.25% 1.0% 4.0%
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Pars Distalis, Hyperplasia 19 (40%) 15 (33%) 22 (44%) 19 (40%)
Thyroid Gland (45) (45) (46) (46)
C-Cell, Hyperplasia 36 (80%) 36 (80%) 38 (83%) 28 (61%)
Follicular Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (48) (44) (48) (48)
Hyperplasia 5 (10%) 2 (5%) 3 (6%) 3 (6%)
Inflammation, Chronic Active 2 (4%) 1 (2%)
Ovary (50) (50) (49) (48)
Cyst 4 (8%) 6 (12%) 7 (14%) 8 (17%)
Inflammation, Granulomatous 1 (2%)
Interstitial Cell, Hyperplasia 1 (2%)
Uterus (50) (48) (50) (49)
Hydrometra 1 (2%)
Hyperplasia, Cystic 1 (2%) 1 (2%) 1 (2%)
Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (15) (11) (8) (14)
Deep Cervical, Ectasia 2 (25%)
Deep Cervical, Hyperplasia 1 (7%)
Iliac, Inflammation, Suppurative 1 (7%)
Mediastinal, Ectasia 1 (9%) 1 (7%)
Mediastinal, Hemorrhage 1 (7%)
Mediastinal, Hyperplasia 1 (7%)
Mediastinal, Infiltration Cellular, Plasma
Cell 1 (9%) 1 (7%)
Pancreatic, Inflammation, Granulomatous 1 (7%)
Lymph Node, Mesenteric (49) (47) (49) (48)
Ectasia 1 (2%)
Spleen (48) (48) (49) (48)
Accessory Spleen 1 (2%)
Hematopoietic Cell Proliferation 7 (15%) 7 (15%) 4 (8%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 88031-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:20:44
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.0% 0.25% 1.0% 4.0%
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hemorrhage 1 (2%) 1 (2%)
Inflammation, Granulomatous 1 (2%) 1 (2%) 3 (6%)
Necrosis 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (49) (50) (49)
Galactocele 3 (6%) 3 (6%) 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%)
Skin (50) (50) (50) (50)
Inflammation, Chronic Active 2 (4%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Inflammation, Chronic Active 1 (2%)
Osteopetrosis 1 (2%) 3 (6%) 1 (2%) 1 (2%)
Skeletal Muscle (1) (1)
Inflammation, Suppurative 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Gliosis 1 (2%)
Inflammation, Suppurative 1 (2%)
Necrosis 1 (2%)
Meninges, Fibrosis 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (49)
Cyst, Squamous 1 (2%)
Infiltration Cellular, Histiocyte 46 (92%) 47 (94%) 46 (92%) 45 (92%)
Inflammation, Chronic Active 8 (16%) 4 (8%) 8 (16%) 11 (22%)
Metaplasia, Osseous 1 (2%)
Metaplasia, Squamous 1 (2%)
Thrombosis 1 (2%)
Alveolar Epithelium, Hyperplasia 11 (22%) 15 (30%) 17 (34%) 8 (16%)
Bronchiole, Hyperplasia 1 (2%) 2 (4%) 3 (6%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 88031-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:20:44
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.0% 0.25% 1.0% 4.0%
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Nose (48) (48) (46) (49)
Inflammation, Suppurative 10 (21%) 5 (10%) 7 (15%) 4 (8%)
Thrombosis 1 (2%) 4 (8%) 3 (6%)
Olfactory Epithelium, Atrophy 1 (2%)
Olfactory Epithelium, Degeneration 9 (18%)
Olfactory Epithelium, Metaplasia 1 (2%) 1 (2%)
Olfactory Epithelium, Metaplasia, Squamous 1 (2%)
Respiratory Epithelium, Accumulation,
Hyaline Droplet 40 (83%) 36 (75%) 37 (80%) 46 (94%)
Respiratory Epithelium, Hyperplasia 1 (2%)
Respiratory Epithelium, Metaplasia, Squamous 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2) (1) (2) (3)
Cataract 2 (100%) 2 (100%) 1 (33%)
Degeneration 2 (67%)
Inflammation, Chronic Active 1 (100%)
Cornea, Inflammation, Suppurative 1 (50%)
Retina, Atrophy 2 (100%) 1 (50%) 2 (67%)
Harderian Gland (1)
Inflammation, Suppurative 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (49) (49) (47)
Cyst 1 (2%)
Hydronephrosis 1 (2%)
Infarct 3 (6%) 2 (4%) 1 (2%) 4 (9%)
Inflammation, Suppurative 1 (2%) 1 (2%)
Mineralization 1 (2%)
Nephropathy 43 (88%) 45 (92%) 47 (96%) 46 (98%)
Pelvis, Inflammation, Acute 1 (2%) 1 (2%)
Renal Tubule, Hypertrophy 1 (2%)
Transitional Epithelium, Hyperplasia 1 (2%) 1 (2%) 1 (2%)
Ureter (1)
Inflammation, Suppurative 1 (100%)
Urinary Bladder (50) (48) (48) (46)
Transitional Epithelium, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 88031-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:20:44
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.0% 0.25% 1.0% 4.0%
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 12 14 18 31
Natural Death 15 9 5 19
Survivors
Terminal Sacrifice 23 27 27
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (41) (49) (48) (43)
Parasite Metazoan 4 (10%) 1 (2%) 3 (6%)
Ulcer 1 (2%) 1 (2%)
Intestine Large, Rectum (40) (50) (48) (44)
Parasite Metazoan 6 (15%) 3 (6%) 6 (13%)
Intestine Large, Cecum (38) (46) (47) (35)
Inflammation, Acute 1 (2%)
Ulcer 1 (2%) 1 (2%)
Intestine Small, Duodenum (39) (49) (49) (42)
Necrosis 1 (2%)
Intestine Small, Ileum (37) (42) (47) (36)
Necrosis 1 (3%)
Liver (50) (50) (49) (48)
Angiectasis 2 (4%)
Basophilic Focus 24 (48%) 35 (70%) 26 (53%) 45 (94%)
Clear Cell Focus 22 (44%) 22 (44%) 23 (47%) 2 (4%)
Degeneration, Cystic 4 (8%) 3 (6%) 6 (12%) 2 (4%)
Eosinophilic Focus 1 (2%) 2 (4%)
Fatty Change 6 (12%) 5 (10%) 3 (6%) 5 (10%)
Hepatodiaphragmatic Nodule 3 (6%) 5 (10%) 4 (8%) 5 (10%)
Inflammation, Focal, Granulomatous 22 (44%) 26 (52%) 42 (86%) 27 (56%)
Inflammation, Focal, Histiocytic 18 (36%) 27 (54%) 46 (94%) 48 (100%)
Mixed Cell Focus 2 (4%) 2 (4%) 2 (4%)
Regeneration 3 (6%)
Thrombosis 1 (2%) 1 (2%)
Vacuolization Cytoplasmic, Focal 1 (2%)
Bile Duct, Hyperplasia 34 (68%) 38 (76%) 43 (88%) 44 (92%)
Centrilobular, Necrosis 15 (30%) 11 (22%) 12 (24%) 3 (6%)
Mesentery (14) (11) (6) (4)
Fat, Inflammation 1 (7%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 88031-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:20:44
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.0% 0.25% 1.0% 4.0%
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Fat, Necrosis 12 (86%) 9 (82%) 5 (83%) 4 (100%)
Oral Mucosa (1) (2)
Pharyngeal, Hyperplasia 1 (50%)
Pharyngeal, Necrosis 1 (100%)
Pancreas (44) (49) (50) (47)
Atrophy 17 (39%) 20 (41%) 12 (24%) 9 (19%)
Basophilic Focus 1 (2%) 2 (4%) 2 (4%)
Hyperplasia 7 (16%) 6 (12%) 4 (8%) 5 (11%)
Thrombosis 1 (2%)
Artery, Inflammation 1 (2%)
Salivary Glands (49) (49) (50) (50)
Atrophy 1 (2%) 5 (10%)
Basophilic Focus 1 (2%) 1 (2%) 1 (2%)
Inflammation, Suppurative 1 (2%) 22 (44%)
Stomach, Forestomach (50) (50) (50) (49)
Cyst 1 (2%)
Hyperkeratosis 1 (2%)
Hyperplasia, Basal Cell 1 (2%) 2 (4%)
Hyperplasia, Diffuse, Squamous 2 (4%) 1 (2%) 1 (2%)
Hyperplasia, Squamous 1 (2%) 3 (6%) 5 (10%)
Inflammation, Chronic 1 (2%)
Inflammation, Suppurative 1 (2%)
Ulcer 3 (6%) 5 (10%) 8 (16%) 10 (20%)
Stomach, Glandular (46) (49) (50) (48)
Cyst, Squamous 1 (2%)
Metaplasia 1 (2%)
Mineralization 1 (2%) 2 (4%)
Necrosis 5 (11%) 7 (14%) 2 (4%) 5 (10%)
Tooth (1) (3)
Inflammation, Chronic Active 1 (100%) 3 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1) (1) (2)
Inflammation, Granulomatous 1 (100%)
Aorta, Mineralization 1 (50%)
Heart (50) (50) (50) (49)
Cardiomyopathy 41 (82%) 42 (84%) 43 (86%) 22 (45%)
Hemorrhage 1 (2%)
Mineralization 7 (14%)
Necrosis 1 (2%)
Atrium, Thrombosis 5 (10%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 88031-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:20:44
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.0% 0.25% 1.0% 4.0%
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - CONT
Valve, Inflammation, Acute 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (47) (49) (50) (48)
Degeneration, Cystic 1 (2%)
Hyperplasia 15 (32%) 22 (45%) 26 (52%) 8 (17%)
Hypertrophy 5 (11%) 4 (8%) 6 (12%) 5 (10%)
Inflammation, Granulomatous 1 (2%)
Necrosis 1 (2%) 4 (8%) 1 (2%)
Vacuolization Cytoplasmic 1 (2%)
Adrenal Medulla (47) (49) (50) (47)
Hyperplasia 23 (49%) 23 (47%) 24 (48%) 4 (9%)
Necrosis 1 (2%) 1 (2%)
Islets, Pancreatic (44) (48) (50) (47)
Hyperplasia 2 (4%)
Parathyroid Gland (45) (48) (49) (50)
Hyperplasia 4 (8%) 1 (2%) 5 (10%)
Pituitary Gland (47) (49) (50) (49)
Angiectasis 1 (2%) 1 (2%)
Cyst 4 (8%) 1 (2%)
Pars Distalis, Hyperplasia 9 (19%) 16 (33%) 16 (32%) 6 (12%)
Thyroid Gland (42) (47) (48) (47)
C-Cell, Hyperplasia 24 (57%) 26 (55%) 31 (65%) 3 (6%)
Follicular Cell, Hyperplasia 1 (2%) 1 (2%) 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (49)
Granuloma Sperm 1 (2%)
Preputial Gland (50) (47) (50) (50)
Cyst 2 (4%)
Hyperplasia 1 (2%) 3 (6%) 3 (6%) 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Prostate (48) (50) (50) (50)
Hyperplasia 11 (23%) 11 (22%) 10 (20%) 5 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 88031-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:20:44
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.0% 0.25% 1.0% 4.0%
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Inflammation, Chronic Active 8 (17%) 8 (16%) 12 (24%)
Seminal Vesicle (43) (48) (49) (46)
Inflammation, Chronic Active 2 (4%)
Testes (50) (50) (50) (50)
Atrophy 2 (4%) 4 (8%) 1 (2%) 3 (6%)
Interstitial Cell, Hyperplasia 3 (6%) 2 (4%) 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (46) (48) (50) (48)
Inflammation, Granulomatous 1 (2%)
Lymph Node (18) (14) (21) (9)
Bronchial, Ectasia 1 (5%)
Mediastinal, Ectasia 2 (11%) 1 (5%) 2 (22%)
Mediastinal, Hemorrhage 1 (11%)
Mediastinal, Hyperplasia 1 (5%)
Mediastinal, Infiltration Cellular, Plasma
Cell 1 (5%)
Mediastinal, Inflammation, Granulomatous 1 (11%)
Lymph Node, Mesenteric (44) (48) (49) (47)
Inflammation, Granulomatous 1 (2%)
Spleen (43) (50) (49) (47)
Atrophy 1 (2%)
Congestion 1 (2%)
Fibrosis 6 (14%) 5 (10%) 4 (8%) 2 (4%)
Hematopoietic Cell Proliferation 2 (5%) 5 (10%) 2 (4%)
Hemorrhage 2 (5%)
Hyperplasia, Focal, Lymphoid 4 (9%) 4 (8%) 9 (18%) 2 (4%)
Necrosis 3 (6%) 2 (4%)
Thymus (39) (48) (43) (41)
Atrophy 1 (2%) 1 (2%)
Hemorrhage 1 (3%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (48) (41) (47) (44)
Galactocele 1 (2%) 1 (2%)
Skin (48) (48) (49) (49)
Cyst 1 (2%)
Foreign Body 1 (2%)
Hyperkeratosis 1 (2%) 4 (8%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 88031-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:20:44
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.0% 0.25% 1.0% 4.0%
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Hyperplasia, Basal Cell 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Prepuce, Inflammation, Suppurative 1 (2%)
Subcutaneous Tissue, Hemorrhage 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1) (2)
Cyst, Squamous 1 (100%)
Mineralization 1 (50%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Gliosis 1 (2%)
Necrosis 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (49) (50) (49)
Foreign Body 1 (2%)
Hemorrhage 1 (2%)
Infiltration Cellular, Histiocyte 32 (64%) 35 (71%) 39 (78%) 34 (69%)
Inflammation, Chronic Active 3 (6%) 2 (4%) 4 (8%) 1 (2%)
Inflammation, Suppurative 1 (2%)
Metaplasia, Squamous 1 (2%) 1 (2%) 3 (6%)
Mineralization 1 (2%) 1 (2%)
Thrombosis 2 (4%) 1 (2%) 3 (6%)
Alveolar Epithelium, Hyperplasia 11 (22%) 18 (37%) 10 (20%) 5 (10%)
Mediastinum, Necrosis, Fatty 1 (2%)
Nose (46) (50) (50) (49)
Foreign Body 2 (4%)
Inflammation, Suppurative 11 (24%) 17 (34%) 15 (30%) 6 (12%)
Thrombosis 2 (4%) 5 (10%) 4 (8%) 9 (18%)
Goblet Cell, Respiratory Epithelium,
Hyperplasia 1 (2%)
Olfactory Epithelium, Atrophy 4 (9%) 3 (6%) 3 (6%) 34 (69%)
Olfactory Epithelium, Degeneration 7 (14%)
Olfactory Epithelium, Metaplasia 4 (9%) 1 (2%) 2 (4%)
Respiratory Epithelium, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 88031-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:20:44
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.0% 0.25% 1.0% 4.0%
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Pleura (2)
Inflammation, Chronic 1 (50%)
Inflammation, Suppurative 1 (50%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2) (2) (3) (1)
Cataract 2 (100%) 1 (50%) 2 (67%) 1 (100%)
Degeneration 1 (33%)
Cornea, Inflammation, Suppurative 1 (50%)
Cornea, Mineralization 1 (50%)
Retina, Atrophy 1 (50%) 1 (50%) 2 (67%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (47) (50) (50) (48)
Cyst 3 (6%)
Hydronephrosis 1 (2%) 1 (2%)
Infarct 3 (6%) 6 (12%) 3 (6%) 2 (4%)
Metaplasia, Osseous 1 (2%)
Mineralization 2 (4%) 1 (2%) 2 (4%)
Nephropathy 41 (87%) 47 (94%) 50 (100%) 48 (100%)
Pigmentation 1 (2%) 2 (4%) 1 (2%)
Papilla, Necrosis 1 (2%)
Renal Tubule, Accumulation, Hyaline Droplet 2 (4%)
Transitional Epithelium, Hyperplasia 1 (2%) 3 (6%) 7 (14%) 9 (19%)
Urinary Bladder (46) (50) (49) (49)
Hemorrhage 1 (2%)
Inflammation, Chronic Active 1 (2%)
Inflammation, Suppurative 1 (2%)
Mineralization 1 (2%)
Necrosis 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------