TDMS Study 88031-05 Pathology Tables
NTP Experiment-Test: 88031-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:26:57
FINAL#3
Facility: Battelle Columbus Laboratory
Chemical CAS #: 25265-71-8
Lock Date: 11/09/99
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 88031-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:26:57
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.0% 0.25% 1.0% 4.0%
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Natural Death 9 10 6 6
Moribund Sacrifice 11 9 6 12
Accidently Killed 1
Survivors
Terminal Sacrifice 30 31 37 31
Natural Death 1
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (48) (47) (48) (46)
Intestine Large, Rectum (48) (47) (49) (46)
Sarcoma, Metastatic, Mesentery 1 (2%)
Sarcoma, Metastatic, Skin 1 (2%)
Intestine Large, Cecum (46) (43) (47) (45)
Intestine Small, Duodenum (47) (46) (47) (47)
Intestine Small, Jejunum (45) (44) (47) (44)
Leiomyoma 1 (2%)
Intestine Small, Ileum (44) (41) (47) (45)
Liver (50) (50) (50) (49)
Histiocytic Sarcoma 2 (4%)
Sarcoma, Metastatic, Mesentery 1 (2%)
Sarcoma, Metastatic, Skin 1 (2%) 1 (2%)
Sarcoma, Metastatic, Skeletal Muscle 1 (2%)
Schwannoma Malignant, Metastatic, Heart 1 (2%)
Mesentery (15) (13) (13) (11)
Histiocytic Sarcoma 1 (8%)
Sarcoma 1 (8%) 2 (18%)
Sarcoma, Metastatic, Ovary 1 (7%)
Sarcoma, Metastatic, Skeletal Muscle 1 (8%)
Pancreas (47) (48) (48) (48)
Adenoma 1 (2%)
Histiocytic Sarcoma 1 (2%)
Sarcoma, Metastatic, Mesentery 1 (2%)
Sarcoma, Metastatic, Ovary 1 (2%)
Salivary Glands (49) (50) (50) (50)
Sarcoma 1 (2%)
Page 2
NTP Experiment-Test: 88031-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:26:57
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.0% 0.25% 1.0% 4.0%
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont
Stomach, Forestomach (50) (49) (50) (48)
Histiocytic Sarcoma 1 (2%)
Sarcoma, Metastatic, Mesentery 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 2 (4%) 1 (2%)
Stomach, Glandular (49) (47) (49) (47)
Tongue (1) (1) (1)
Squamous Cell Carcinoma 1 (100%) 1 (100%)
Squamous Cell Papilloma 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Hemangiosarcoma 1 (2%)
Schwannoma Benign 2 (4%) 4 (8%) 1 (2%)
Schwannoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (49) (47) (47) (47)
Adenoma 1 (2%) 1 (2%)
Adrenal Medulla (49) (47) (46) (47)
Pheochromocytoma Malignant 2 (4%)
Pheochromocytoma Benign 3 (6%) 1 (2%)
Islets, Pancreatic (47) (48) (48) (48)
Adenoma 1 (2%)
Pituitary Gland (48) (45) (50) (47)
Pars Distalis, Adenoma 20 (42%) 18 (40%) 20 (40%) 13 (28%)
Pars Distalis, Carcinoma 1 (2%) 1 (2%)
Thyroid Gland (45) (45) (46) (46)
Bilateral, C-Cell, Adenoma 1 (2%)
C-Cell, Adenoma 5 (11%) 8 (18%) 3 (7%) 3 (7%)
C-Cell, Carcinoma 1 (2%) 1 (2%) 2 (4%) 1 (2%)
Follicular Cell, Carcinoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 88031-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:26:57
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.0% 0.25% 1.0% 4.0%
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Peritoneum (1)
Sarcoma, Metastatic, Mesentery 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (48) (44) (48) (48)
Adenoma 6 (13%) 8 (18%) 4 (8%) 4 (8%)
Carcinoma 4 (8%) 5 (11%) 2 (4%) 1 (2%)
Sarcoma 1 (2%)
Bilateral, Adenoma 1 (2%)
Bilateral, Carcinoma 1 (2%)
Ovary (50) (50) (49) (48)
Histiocytic Sarcoma 1 (2%)
Sarcoma 1 (2%)
Sarcoma, Metastatic, Mesentery 1 (2%)
Sarcoma, Metastatic, Skeletal Muscle 1 (2%)
Uterus (50) (48) (50) (49)
Adenoma 1 (2%) 1 (2%)
Carcinoma 1 (2%)
Polyp Stromal 8 (16%) 10 (21%) 6 (12%) 11 (22%)
Polyp Stromal, Multiple 2 (4%) 1 (2%)
Sarcoma, Metastatic, Ovary 1 (2%)
Sarcoma Stromal 1 (2%) 2 (4%)
Vagina (1)
Sarcoma, Metastatic, Skeletal Muscle 1 (100%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (48) (47) (48) (47)
Lymph Node (15) (11) (8) (14)
Mediastinal, Histiocytic Sarcoma 1 (13%)
Lymph Node, Mandibular (18) (12) (14) (14)
Lymph Node, Mesenteric (49) (47) (49) (48)
Histiocytic Sarcoma 1 (2%)
Sarcoma, Metastatic, Ovary 1 (2%)
Spleen (48) (48) (49) (48)
Histiocytic Sarcoma 1 (2%)
Sarcoma, Metastatic, Ovary 1 (2%)
Sarcoma, Metastatic, Skin 1 (2%)
Sarcoma, Metastatic, Skeletal Muscle 1 (2%)
Page 4
NTP Experiment-Test: 88031-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:26:57
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.0% 0.25% 1.0% 4.0%
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Thymus (48) (49) (48) (39)
Thymoma Benign 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (49) (50) (49)
Carcinoma 4 (8%) 4 (8%) 2 (4%) 2 (4%)
Fibroadenoma 20 (40%) 24 (49%) 14 (28%) 19 (39%)
Fibroadenoma, Multiple 16 (32%) 11 (22%) 16 (32%) 3 (6%)
Sarcoma 1 (2%)
Skin (50) (50) (50) (50)
Trichoepithelioma 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%)
Subcutaneous Tissue, Histiocytic Sarcoma 1 (2%)
Subcutaneous Tissue, Sarcoma 2 (4%) 2 (4%)
Subcutaneous Tissue, Schwannoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Osteosarcoma 1 (2%)
Skeletal Muscle (1) (1)
Sarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Osteosarcoma, Metastatic, Bone 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (49)
Alveolar/Bronchiolar Adenoma 2 (4%)
Alveolar/Bronchiolar Carcinoma 1 (2%) 1 (2%) 1 (2%)
Carcinoma, Metastatic, Mammary Gland 1 (2%)
Histiocytic Sarcoma 1 (2%)
Sarcoma, Metastatic, Skin 1 (2%) 1 (2%)
Sarcoma, Metastatic, Skeletal Muscle 1 (2%)
Mediastinum, Sarcoma, Metastatic, Skeletal
Page 5
NTP Experiment-Test: 88031-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:26:57
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.0% 0.25% 1.0% 4.0%
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont
Muscle 1 (2%)
Mediastinum, Schwannoma Malignant,
Metastatic, Heart 1 (2%)
Nose (48) (48) (46) (49)
Pleura (1)
Sarcoma, Metastatic, Mesentery 1 (100%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (49) (49) (47)
Hemangiosarcoma 1 (2%)
Histiocytic Sarcoma 1 (2%)
Mesenchymal Tumor Malignant 1 (2%)
Sarcoma, Metastatic, Skeletal Muscle 1 (2%)
Urinary Bladder (50) (48) (48) (46)
Sarcoma, Metastatic, Skin 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Histiocytic Sarcoma 2 (4%)
Leukemia Mononuclear 10 (20%) 10 (20%) 4 (8%) 13 (26%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 6
NTP Experiment-Test: 88031-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:26:57
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.0% 0.25% 1.0% 4.0%
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 50 49 46 46
Total Primary Neoplasms 111 121 93 80
Total Animals with Benign Neoplasms 44 45 40 36
Total Benign Neoplasms 83 93 70 56
Total Animals with Malignant Neoplasms 25 24 20 21
Total Malignant Neoplasms 28 28 23 24
Total Animals with Metastatic Neoplasms 1 3 4 2
Total Metastatic Neoplasm 5 15 5 6
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 7
NTP Experiment-Test: 88031-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:26:57
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.0% 0.25% 1.0% 4.0%
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Moribund Sacrifice 12 14 18 31
Natural Death 15 9 5 19
Survivors
Terminal Sacrifice 23 27 27
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (41) (49) (48) (43)
Polyp Adenomatous 1 (2%)
Intestine Large, Cecum (38) (46) (47) (35)
Intestine Small, Duodenum (39) (49) (49) (42)
Intestine Small, Jejunum (37) (45) (48) (39)
Carcinoma 1 (2%)
Leiomyoma 1 (2%)
Intestine Small, Ileum (37) (42) (47) (36)
Polyp Adenomatous 1 (2%)
Liver (50) (50) (49) (48)
Hepatocellular Adenoma 1 (2%)
Sarcoma, Metastatic, Skin 1 (2%)
Mesentery (14) (11) (6) (4)
Oral Mucosa (1) (2)
Pharyngeal, Squamous Cell Papilloma 1 (50%)
Pancreas (44) (49) (50) (47)
Adenoma 1 (2%) 1 (2%)
Carcinoma 1 (2%)
Fibrosarcoma, Metastatic, Tissue NOS 1 (2%)
Mixed Tumor Benign 2 (5%)
Salivary Glands (49) (49) (50) (50)
Carcinoma 1 (2%)
Sarcoma 1 (2%) 3 (6%)
Schwannoma Malignant 2 (4%)
Stomach, Forestomach (50) (50) (50) (49)
Stomach, Glandular (46) (49) (50) (48)
Tongue (1) (1)
Squamous Cell Papilloma 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 88031-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:26:57
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.0% 0.25% 1.0% 4.0%
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (49)
Sarcoma, Metastatic, Skin 1 (2%) 1 (2%)
Schwannoma Benign 2 (4%) 3 (6%) 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (47) (49) (50) (48)
Adenoma 2 (4%)
Carcinoma 1 (2%)
Pheochromocytoma Malignant, Metastatic,
Adrenal Medulla 1 (2%)
Sarcoma, Metastatic, Skin 1 (2%)
Adrenal Medulla (47) (49) (50) (47)
Ganglioneuroma 1 (2%)
Pheochromocytoma Malignant 5 (11%) 2 (4%)
Pheochromocytoma Complex 1 (2%)
Pheochromocytoma Benign 4 (9%) 7 (14%) 11 (22%) 1 (2%)
Bilateral, Pheochromocytoma Benign 1 (2%)
Islets, Pancreatic (44) (48) (50) (47)
Adenoma 2 (5%) 3 (6%)
Carcinoma 4 (8%) 2 (4%)
Parathyroid Gland (45) (48) (49) (50)
Adenoma 1 (2%) 2 (4%)
Pituitary Gland (47) (49) (50) (49)
Pars Distalis, Adenoma 15 (32%) 21 (43%) 18 (36%) 7 (14%)
Pars Distalis, Carcinoma 1 (2%)
Pars Intermedia, Adenoma 1 (2%)
Thyroid Gland (42) (47) (48) (47)
C-Cell, Adenoma 4 (10%) 4 (9%) 6 (13%)
C-Cell, Carcinoma 2 (5%) 3 (6%) 2 (4%)
Follicular Cell, Adenoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Peritoneum (3) (2) (2)
Tissue NOS (1) (1)
Fibrosarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
Page 9
NTP Experiment-Test: 88031-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:26:57
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.0% 0.25% 1.0% 4.0%
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (49)
Preputial Gland (50) (47) (50) (50)
Adenoma 3 (6%) 1 (2%) 3 (6%) 1 (2%)
Carcinoma 3 (6%) 1 (2%) 1 (2%)
Sarcoma 1 (2%)
Bilateral, Carcinoma 1 (2%)
Prostate (48) (50) (50) (50)
Adenoma 1 (2%) 1 (2%) 2 (4%)
Hemangiosarcoma 1 (2%)
Seminal Vesicle (43) (48) (49) (46)
Testes (50) (50) (50) (50)
Bilateral, Interstitial Cell, Adenoma 39 (78%) 41 (82%) 41 (82%) 44 (88%)
Interstitial Cell, Adenoma 6 (12%) 4 (8%) 2 (4%) 4 (8%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (46) (48) (50) (48)
Pheochromocytoma Malignant, Metastatic,
Adrenal Medulla 1 (2%)
Lymph Node (18) (14) (21) (9)
Deep Cervical, Carcinoma, Metastatic,
Thyroid Gland 1 (7%)
Mediastinal, Carcinoma, Metastatic, Thyroid
Gland 1 (7%)
Lymph Node, Mandibular (13) (16) (14) (11)
Carcinoma, Metastatic, Zymbal's Gland 1 (6%)
Lymph Node, Mesenteric (44) (48) (49) (47)
Spleen (43) (50) (49) (47)
Thymus (39) (48) (43) (41)
Thymoma Benign 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (48) (41) (47) (44)
Fibroadenoma 1 (2%) 6 (15%) 1 (2%)
Fibroadenoma, Multiple 1 (2%)
Skin (48) (48) (49) (49)
Keratoacanthoma 1 (2%) 2 (4%) 4 (8%)
Keratoacanthoma, Multiple 1 (2%)
Squamous Cell Carcinoma 2 (4%)
Page 10
NTP Experiment-Test: 88031-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:26:57
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.0% 0.25% 1.0% 4.0%
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont
Sebaceous Gland, Adenoma 1 (2%) 1 (2%)
Subcutaneous Tissue, Fibroma 6 (13%) 5 (10%) 3 (6%) 1 (2%)
Subcutaneous Tissue, Lipoma 1 (2%) 1 (2%)
Subcutaneous Tissue, Sarcoma 3 (6%) 5 (10%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Osteosarcoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Granular Cell Tumor Benign 1 (2%)
Sarcoma 1 (2%)
Peripheral Nerve (1) (1)
Sarcoma 1 (100%)
Spinal Cord (1) (1)
Osteosarcoma, Metastatic, Bone 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (49) (50) (49)
Alveolar/Bronchiolar Adenoma 2 (4%) 3 (6%) 1 (2%)
Alveolar/Bronchiolar Carcinoma 1 (2%) 2 (4%) 2 (4%) 1 (2%)
Carcinoma, Metastatic, Pituitary Gland 1 (2%)
Carcinoma, Metastatic, Preputial Gland 1 (2%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%) 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%) 1 (2%)
Pheochromocytoma Malignant, Metastatic,
Adrenal Medulla 1 (2%)
Sarcoma, Metastatic, Salivary Glands 1 (2%) 1 (2%)
Sarcoma, Metastatic, Skin 1 (2%) 1 (2%)
Squamous Cell Carcinoma, Metastatic, Oral
Mucosa 1 (2%)
Nose (46) (50) (50) (49)
Trachea (43) (49) (49) (47)
____________________________________________________________________________________________________________________________________
Page 11
NTP Experiment-Test: 88031-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:26:57
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.0% 0.25% 1.0% 4.0%
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (3) (2) (1) (1)
Carcinoma 3 (100%) 2 (100%) 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (47) (50) (50) (48)
Lipoma 2 (4%)
Sarcoma, Metastatic, Skin 1 (2%)
Stromal Nephroma 1 (2%)
Renal Tubule, Adenoma 1 (2%)
Renal Tubule, Carcinoma 1 (2%)
Urinary Bladder (46) (50) (49) (49)
Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Leukemia Mononuclear 16 (32%) 20 (40%) 22 (44%) 5 (10%)
Lymphoma Malignant 1 (2%) 1 (2%)
Mesothelioma Benign 1 (2%)
Mesothelioma Malignant 6 (12%) 2 (4%) 2 (4%) 2 (4%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 12
NTP Experiment-Test: 88031-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:26:57
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.0% 0.25% 1.0% 4.0%
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 49 50 50 50
Total Primary Neoplasms 141 161 142 75
Total Animals with Benign Neoplasms 47 49 50 49
Total Benign Neoplasms 95 117 97 62
Total Animals with Malignant Neoplasms 35 34 35 12
Total Malignant Neoplasms 46 44 45 13
Total Animals with Metastatic Neoplasms 3 4 4 2
Total Metastatic Neoplasm 9 7 7 2
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 13
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