TDMS Study 88031-05 Pathology Tables
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
FINAL#3
Facility: Battelle Columbus Laboratory
Chemical CAS #: 25265-71-8
Lock Date: 11/09/99
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 6| 7| 7| 7| 4| 7| 2| 7| 6| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 2| 3| 3| 2| 3| 2| 3| 4| 9| 2| 5| 3| 3| 3| 1| 3| 4| 3| 9| 3| 2| 3| 2| 9| 3|
| 9| 0| 1| 9| 1| 9| 1| 0| 7| 4| 9| 1| 1| 1| 3| 0| 7| 0| 7| 1| 9| 1| 9| 6| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.0% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + A + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + A + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + A A + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + A A + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + A + A A + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A + A A + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X|
Fatty Change | 2 3 2 |
Hepatodiaphragmatic Nodule | X |
Inflammation, Focal, Granulomatous | 1 1 1 1 1 1 1 2 1 1 1 1 1 2 2 1|
Inflammation, Focal, Histiocytic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Mixed Cell Focus | |
Bile Duct, Hyperplasia | 2 1|
Centrilobular, Necrosis | 1 1 3 1 |
|__________________________________________________________________________|
Mesentery | + + + + + + + + + |
Fat, Necrosis | 2 2 2 2 2 2 2 3 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + A A + + + + + + + + + + + + + +|
Atrophy | 1 2 2 1 |
Basophilic Focus | X X |
Hyperplasia | 1 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + M + + + + + + + + + + + + + +|
Atrophy | 1 2 |
__________________________________________|__________________________________________________________________________|
Page 2
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 6| 7| 7| 7| 4| 7| 2| 7| 6| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 2| 3| 3| 2| 3| 2| 3| 4| 9| 2| 5| 3| 3| 3| 1| 3| 4| 3| 9| 3| 2| 3| 2| 9| 3|
| 9| 0| 1| 9| 1| 9| 1| 0| 7| 4| 9| 1| 1| 1| 3| 0| 7| 0| 7| 1| 9| 1| 9| 6| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.0% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Basophilic Focus | X |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X |
Hyperplasia, Squamous | 2 1 2 |
Inflammation, Granulomatous | 1 |
Ulcer | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + A + + + + + + + + + + + + + +|
Mineralization | 1 |
Necrosis | 2 3 |
|__________________________________________________________________________|
Tongue | |
|__________________________________________________________________________|
Tooth | + + + + |
Inflammation, Chronic Active | 2 3 2 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 2 2 1 1 2 1 1 2 1 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 2 |
Hyperplasia | 2 1 1 2 2 2 2 1 2 |
Hypertrophy | 2 3 3 1 |
Necrosis | |
Thrombosis | 2 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 1 2 1 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + A A + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 3
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 6| 7| 7| 7| 4| 7| 2| 7| 6| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 2| 3| 3| 2| 3| 2| 3| 4| 9| 2| 5| 3| 3| 3| 1| 3| 4| 3| 9| 3| 2| 3| 2| 9| 3|
| 9| 0| 1| 9| 1| 9| 1| 0| 7| 4| 9| 1| 1| 1| 3| 0| 7| 0| 7| 1| 9| 1| 9| 6| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.0% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Pituitary Gland | + + + + + + + + + A + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 4 3 2 1 2 2 4 3 2 2|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + A M + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 2 2 1 1 2 3 2 2 1 1 1 2 3 1 3 2 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + M M + + + + + + + + + + + + +|
Hyperplasia | 1 |
Inflammation, Chronic Active | |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 2|
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | |
Hyperplasia, Cystic | |
Thrombosis | 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + A + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + + + + + + |
Iliac, Inflammation, Suppurative | 4 |
Mediastinal, Hemorrhage | 2 |
Mediastinal, Hyperplasia | |
Pancreatic, Inflammation, | |
Granulomatous | |
|__________________________________________________________________________|
Lymph Node, Mandibular | M M + M M + + M M M M + M M M M M + M M + M M M +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + A + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 4
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 6| 7| 7| 7| 4| 7| 2| 7| 6| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 2| 3| 3| 2| 3| 2| 3| 4| 9| 2| 5| 3| 3| 3| 1| 3| 4| 3| 9| 3| 2| 3| 2| 9| 3|
| 9| 0| 1| 9| 1| 9| 1| 0| 7| 4| 9| 1| 1| 1| 3| 0| 7| 0| 7| 1| 9| 1| 9| 6| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.0% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Spleen | + + + + + + + + + A A + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 3 4 |
Hemorrhage | 2 |
Necrosis | 2 |
|__________________________________________________________________________|
Thymus | + + M + + + + + + + + + + + + + + + + M + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 2 4 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Osteopetrosis | |
|__________________________________________________________________________|
Skeletal Muscle | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Inflammation, Chronic Active | 1 1 1|
Thrombosis | 2 |
Alveolar Epithelium, Hyperplasia | 1 1 1 2|
Bronchiole, Hyperplasia | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 5
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 6| 7| 7| 7| 4| 7| 2| 7| 6| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 2| 3| 3| 2| 3| 2| 3| 4| 9| 2| 5| 3| 3| 3| 1| 3| 4| 3| 9| 3| 2| 3| 2| 9| 3|
| 9| 0| 1| 9| 1| 9| 1| 0| 7| 4| 9| 1| 1| 1| 3| 0| 7| 0| 7| 1| 9| 1| 9| 6| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.0% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Inflammation, Suppurative | 1 1 1 2 |
Thrombosis | |
Respiratory Epithelium, Accumulation,| |
Hyaline Droplet | 2 2 3 2 1 2 3 2 3 2 1 1 2 2 2 2 2 1 2|
Respiratory Epithelium, Metaplasia, | |
Squamous | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + A + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | |
Cataract | |
Cornea, Inflammation, Suppurative | |
Retina, Atrophy | |
|__________________________________________________________________________|
Harderian Gland | |
Inflammation, Suppurative | |
|__________________________________________________________________________|
Lacrimal Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + A + + + + + + + + + + + + + +|
Infarct | 2 3 2 |
Inflammation, Suppurative | 4 |
Mineralization | |
Nephropathy | 2 2 1 2 1 1 2 1 2 1 1 1 1 3 1 1 1 1 1 1 1 1|
Renal Tubule, Hypertrophy | 2 |
|__________________________________________________________________________|
Ureter | + |
Inflammation, Suppurative | 4 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 6
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 7| 7| 7| 7| 5| 7| 6| 5| 7| 6| 7| 7| 6| 6| 7| 7| 5| 7| 7| 7| |
DAY ON TEST | 3| 2| 3| 2| 2| 0| 3| 2| 3| 4| 3| 9| 2| 3| 9| 3| 3| 2| 9| 2| 3| 4| 3| 3| 0| |
| 0| 4| 1| 6| 9| 2| 1| 9| 0| 3| 1| 7| 7| 1| 7| 1| 1| 6| 6| 8| 1| 2| 0| 0| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0.0% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + A| 48 |
Parasite Metazoan | X X | 4 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + A| 48 |
Parasite Metazoan | X X X X | 7 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + + + + + + + A| 46 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + A + + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + + + + + + + + A| 45 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + + + + + + A + + + + + + + + + + + + + + A| 44 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X X | 46 |
Clear Cell Focus | X X X X X | 10 |
Fatty Change | 2 2 2| 6 2.2|
Hepatodiaphragmatic Nodule | X X X | 4 |
Inflammation, Focal, Granulomatous | 1 2 1 1 1 1 2 1 2 1 1 1 1 1 | 30 1.2|
Inflammation, Focal, Histiocytic | 1 1 2 2 1 1 1 1 1 1 1 2 1 1 1 1 2 1 | 39 1.1|
Mixed Cell Focus | X | 1 |
Bile Duct, Hyperplasia | | 2 1.5|
Centrilobular, Necrosis | 1 3| 6 1.7|
|__________________________________________________________________________|____________|
Mesentery | + + + + + + | 15 |
Fat, Necrosis | 2 2 2 2 2 3 | 14 2.1|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + A + + + + + + + + + + + + + + +| 47 |
Atrophy | 2 1 2 | 7 1.6|
Basophilic Focus | X | 3 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 7| 7| 7| 7| 5| 7| 6| 5| 7| 6| 7| 7| 6| 6| 7| 7| 5| 7| 7| 7| |
DAY ON TEST | 3| 2| 3| 2| 2| 0| 3| 2| 3| 4| 3| 9| 2| 3| 9| 3| 3| 2| 9| 2| 3| 4| 3| 3| 0| |
| 0| 4| 1| 6| 9| 2| 1| 9| 0| 3| 1| 7| 7| 1| 7| 1| 1| 6| 6| 8| 1| 2| 0| 0| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0.0% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Hyperplasia | 2 | 2 1.5|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 2 | 3 1.7|
Basophilic Focus | | 1 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | | 1 |
Hyperplasia, Squamous | 1 | 4 1.5|
Inflammation, Granulomatous | | 1 1.0|
Ulcer | 3 3| 2 3.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Mineralization | | 1 1.0|
Necrosis | 3| 3 2.7|
|__________________________________________________________________________|____________|
Tongue | + | 1 |
|__________________________________________________________________________|____________|
Tooth | + + | 6 |
Inflammation, Chronic Active | 2 3 | 6 2.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 2 1 1 2 1 1 1 1 1 1 2 1 3 1 1 2| 33 1.3|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
Degeneration, Cystic | 2 2 4 | 5 2.4|
Hyperplasia | 2 1 2 2 1 2 1 2 1 | 18 1.6|
Hypertrophy | 1 1 2 1 1 1 2 | 11 1.6|
Necrosis | 3| 1 3.0|
Thrombosis | | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 7| 7| 7| 7| 5| 7| 6| 5| 7| 6| 7| 7| 6| 6| 7| 7| 5| 7| 7| 7| |
DAY ON TEST | 3| 2| 3| 2| 2| 0| 3| 2| 3| 4| 3| 9| 2| 3| 9| 3| 3| 2| 9| 2| 3| 4| 3| 3| 0| |
| 0| 4| 1| 6| 9| 2| 1| 9| 0| 3| 1| 7| 7| 1| 7| 1| 1| 6| 6| 8| 1| 2| 0| 0| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0.0% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 1 2 1 2 2 1 1 | 12 1.4|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + A + + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 |
Pars Distalis, Hyperplasia | 1 3 3 3 1 1 2 1 3 | 19 2.3|
|__________________________________________________________________________|____________|
Thyroid Gland | + A + + + + + + + A + + + + + + + + + + + + + + A| 45 |
C-Cell, Hyperplasia | 3 1 1 2 1 3 2 1 1 2 3 2 1 1 2 3 2 | 36 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 1 3 3 2 | 5 2.0|
Inflammation, Chronic Active | 3 3 | 2 3.0|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 3 | 4 2.8|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrometra | 4 | 1 4.0|
Hyperplasia, Cystic | 4 | 1 4.0|
Thrombosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 7| 7| 7| 7| 5| 7| 6| 5| 7| 6| 7| 7| 6| 6| 7| 7| 5| 7| 7| 7| |
DAY ON TEST | 3| 2| 3| 2| 2| 0| 3| 2| 3| 4| 3| 9| 2| 3| 9| 3| 3| 2| 9| 2| 3| 4| 3| 3| 0| |
| 0| 4| 1| 6| 9| 2| 1| 9| 0| 3| 1| 7| 7| 1| 7| 1| 1| 6| 6| 8| 1| 2| 0| 0| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0.0% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + +| 15 |
Iliac, Inflammation, Suppurative | | 1 4.0|
Mediastinal, Hemorrhage | | 1 2.0|
Mediastinal, Hyperplasia | 2 | 1 2.0|
Pancreatic, Inflammation, | | |
Granulomatous | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M + M M M M M + M M + M M M M M + + + + + + M| 18 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hematopoietic Cell Proliferation | 3 4 3 2 | 7 3.3|
Hemorrhage | | 1 2.0|
Necrosis | | 1 2.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | 3 | 3 3.0|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 4 | 1 4.0|
Osteopetrosis | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
Inflammation, Suppurative | 4 | 1 4.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 7| 7| 7| 7| 5| 7| 6| 5| 7| 6| 7| 7| 6| 6| 7| 7| 5| 7| 7| 7| |
DAY ON TEST | 3| 2| 3| 2| 2| 0| 3| 2| 3| 4| 3| 9| 2| 3| 9| 3| 3| 2| 9| 2| 3| 4| 3| 3| 0| |
| 0| 4| 1| 6| 9| 2| 1| 9| 0| 3| 1| 7| 7| 1| 7| 1| 1| 6| 6| 8| 1| 2| 0| 0| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0.0% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 | 46 1.0|
Inflammation, Chronic Active | 1 1 1 1 1 | 8 1.0|
Thrombosis | | 1 2.0|
Alveolar Epithelium, Hyperplasia | 1 4 1 1 1 2 1 | 11 1.5|
Bronchiole, Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 |
Inflammation, Suppurative | 2 1 2 2 2 2| 10 1.6|
Thrombosis | 1| 1 1.0|
Respiratory Epithelium, Accumulation,| | |
Hyaline Droplet | 2 2 3 2 2 3 1 1 2 3 1 1 3 1 1 1 1 3 2 4 2 | 40 2.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + | 2 |
Cataract | 3 4 | 2 3.5|
Cornea, Inflammation, Suppurative | 4 | 1 4.0|
Retina, Atrophy | 4 4 | 2 4.0|
|__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
Inflammation, Suppurative | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Lacrimal Gland | | 1 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 7| 7| 7| 7| 5| 7| 6| 5| 7| 6| 7| 7| 6| 6| 7| 7| 5| 7| 7| 7| |
DAY ON TEST | 3| 2| 3| 2| 2| 0| 3| 2| 3| 4| 3| 9| 2| 3| 9| 3| 3| 2| 9| 2| 3| 4| 3| 3| 0| |
| 0| 4| 1| 6| 9| 2| 1| 9| 0| 3| 1| 7| 7| 1| 7| 1| 1| 6| 6| 8| 1| 2| 0| 0| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0.0% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Infarct | | 3 2.3|
Inflammation, Suppurative | | 1 4.0|
Mineralization | 2 | 1 2.0|
Nephropathy | 2 1 1 2 2 1 1 1 1 1 1 1 1 3 2 1 1 1 1 2 1 | 43 1.3|
Renal Tubule, Hypertrophy | | 1 2.0|
|__________________________________________________________________________|____________|
Ureter | | 1 |
Inflammation, Suppurative | | 1 4.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 2| 3| 8| 3| 1| 3| 6| 8| 3| 3| 8| 2| 3| 2| 2| 1| 3| 3| 3| 3| 2| 3| 3|
| 0| 5| 9| 1| 5| 0| 7| 0| 8| 5| 1| 1| 0| 9| 4| 5| 9| 7| 1| 0| 1| 0| 2| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.25% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + A + + + + + + + + + +|
Parasite Metazoan | X X |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + A + A + + A + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + A + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + A + A + + A + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + + + + + + A + A + + A + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X X X|
Fatty Change | 3 2 4 3 3 |
Hepatodiaphragmatic Nodule | X X |
Inflammation, Focal, Granulomatous | 1 2 1 3 1 1 1 2 1 1 1 1 1 1 1 1 1|
Inflammation, Focal, Histiocytic | 1 2 1 1 2 1 1 1 2 1 1 1 1 1 2 1|
Mixed Cell Focus | X X X X X X|
Necrosis | 3 |
Tension Lipidosis | |
Bile Duct, Hyperplasia | 1 |
Centrilobular, Necrosis | 1 1 2 2 2 |
|__________________________________________________________________________|
Mesentery | + + + + + + + +|
Fat, Hemorrhage | |
Fat, Necrosis | 2 2 2 2 2 2 3 2|
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 1 1 1 1 |
Basophilic Focus | X |
__________________________________________|__________________________________________________________________________|
Page 13
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 2| 3| 8| 3| 1| 3| 6| 8| 3| 3| 8| 2| 3| 2| 2| 1| 3| 3| 3| 3| 2| 3| 3|
| 0| 5| 9| 1| 5| 0| 7| 0| 8| 5| 1| 1| 0| 9| 4| 5| 9| 7| 1| 0| 1| 0| 2| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.25% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Hyperplasia | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 3 |
Basophilic Focus | X X X |
Inflammation, Suppurative | |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 2 3 |
Ulcer | 4 3 3 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + A + + + + + + +|
Hypertrophy, Focal | |
Inflammation, Chronic | |
Mineralization | |
Necrosis | 1 |
Neuroendocrine Cell, Hyperplasia | |
|__________________________________________________________________________|
Tooth | + |
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 2 1 1 2 1 2 1 2 2 1 2 1 2 1 1 1 1 1 1|
Atrium, Thrombosis | 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Atrophy | 4 |
Degeneration, Cystic | 2 |
Hyperplasia | 2 2 2 2 1 2 2 1 2 2 2|
Hypertrophy | 2 2 1 2 3 2 2 2 2|
Necrosis | 3 2 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 14
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 2| 3| 8| 3| 1| 3| 6| 8| 3| 3| 8| 2| 3| 2| 2| 1| 3| 3| 3| 3| 2| 3| 3|
| 0| 5| 9| 1| 5| 0| 7| 0| 8| 5| 1| 1| 0| 9| 4| 5| 9| 7| 1| 0| 1| 0| 2| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.25% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Hyperplasia | 2 1 1 1 1 1 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + M + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + A + + + + A + + + + + + +|
Cyst | |
Pars Distalis, Hyperplasia | 3 2 3 2 3 1 1 2 3 1 3|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + A + A + + A + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 1 4 1 2 2 2 2 1 1 1 2 1 2 1|
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + M + + + + M + + + + + + + + + M M + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 3 2 3 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + + + + + |
Mediastinal, Ectasia | |
Mediastinal, Infiltration Cellular, | |
Plasma Cell | 3 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 15
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 2| 3| 8| 3| 1| 3| 6| 8| 3| 3| 8| 2| 3| 2| 2| 1| 3| 3| 3| 3| 2| 3| 3|
| 0| 5| 9| 1| 5| 0| 7| 0| 8| 5| 1| 1| 0| 9| 4| 5| 9| 7| 1| 0| 1| 0| 2| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.25% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Lymph Node, Mandibular | M M M M + M + M M M + + M M + M M M M M + + M M M|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + A + + + + + + +|
Hematopoietic Cell Proliferation | 4 2 4 2 |
Inflammation, Granulomatous | 3 |
Necrosis | 2 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 2 3 |
Inflammation, Chronic | |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | 2 |
|__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Gliosis | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Inflammation, Chronic Active | 1 |
Metaplasia, Osseous | 1 |
__________________________________________|__________________________________________________________________________|
Page 16
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 2| 3| 8| 3| 1| 3| 6| 8| 3| 3| 8| 2| 3| 2| 2| 1| 3| 3| 3| 3| 2| 3| 3|
| 0| 5| 9| 1| 5| 0| 7| 0| 8| 5| 1| 1| 0| 9| 4| 5| 9| 7| 1| 0| 1| 0| 2| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.25% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Alveolar Epithelium, Hyperplasia | 1 1 1 3 1 1 |
Bronchiole, Hyperplasia | 3 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 1 2 |
Thrombosis | 2 3 2 |
Respiratory Epithelium, Accumulation,| |
Hyaline Droplet | 1 3 2 1 2 1 1 3 3 1 2 1 2 2 2 2 1 2 1|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + A + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + |
Inflammation, Chronic Active | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | |
Infarct | 2 |
Inflammation, Suppurative | |
Nephropathy | 1 2 1 1 2 3 1 1 2 2 2 1 1 1 1 1 1 1 1 1 1 1 2|
Pelvis, Inflammation, Acute | |
Transitional Epithelium, Hyperplasia | 1 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 17
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 4| 7| 7| 7| 5| 4| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 8| 2| 2| 1| 3| 3| 3| 4| 2| 3| 3| 8| 4| 3| 3| 2| 2| 3| 3| 3| 2| 3| 2| 3| 2| |
| 3| 1| 9| 7| 0| 1| 0| 2| 5| 0| 1| 5| 1| 1| 0| 9| 4| 0| 1| 1| 9| 0| 9| 0| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
0.25% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + A + + + + + + + + + + + + + M A + + + + + + + +| 47 |
Parasite Metazoan | X | 4 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + A + + + + + + + + + + + + + + A + + + + + + + +| 47 |
Parasite Metazoan | X X X | 5 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + A + + + + A + + + + + + + A + + + + + + + +| 43 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + + + + + + + + + + + + + + A + + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + + + + + + A + + + + + + + A + + + + + + + +| 44 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + A + + + A A + + + + + + + A + + + + + + + +| 41 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 1 | 2 1.0|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X X| 46 |
Clear Cell Focus | X X X X X X X X| 16 |
Fatty Change | 3 2 1 2 | 9 2.6|
Hepatodiaphragmatic Nodule | X X X X X | 7 |
Inflammation, Focal, Granulomatous | 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 33 1.2|
Inflammation, Focal, Histiocytic | 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 37 1.1|
Mixed Cell Focus | X | 7 |
Necrosis | | 1 3.0|
Tension Lipidosis | X | 1 |
Bile Duct, Hyperplasia | 1 1 | 3 1.0|
Centrilobular, Necrosis | 2 2 2 | 8 1.8|
|__________________________________________________________________________|____________|
Mesentery | + + + + + | 13 |
Fat, Hemorrhage | 3 | 1 3.0|
Fat, Necrosis | 2 2 2 2 2 | 13 2.1|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 4| 7| 7| 7| 5| 4| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 8| 2| 2| 1| 3| 3| 3| 4| 2| 3| 3| 8| 4| 3| 3| 2| 2| 3| 3| 3| 2| 3| 2| 3| 2| |
| 3| 1| 9| 7| 0| 1| 0| 2| 5| 0| 1| 5| 1| 1| 0| 9| 4| 0| 1| 1| 9| 0| 9| 0| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
0.25% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Pancreas | + A + + + + + + + + + + + + + + A + + + + + + + +| 48 |
Atrophy | 1 4 1 1 | 10 1.3|
Basophilic Focus | X | 2 |
Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 | 4 1.5|
Basophilic Focus | | 3 |
Inflammation, Suppurative | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Squamous | 2 | 3 2.3|
Ulcer | 2 3 3 | 6 3.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + A + + + + + + + + + + + + + + A + + + + + + + +| 47 |
Hypertrophy, Focal | 2 | 1 2.0|
Inflammation, Chronic | 2 | 1 2.0|
Mineralization | 1 | 1 1.0|
Necrosis | 1 | 2 1.0|
Neuroendocrine Cell, Hyperplasia | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Tooth | + | 2 |
Inflammation, Chronic Active | 4 | 2 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 2 1 3 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1| 42 1.3|
Atrium, Thrombosis | | 2 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + A + A + + + + + + + + + + + + A + + + + + + + +| 47 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 4| 7| 7| 7| 5| 4| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 8| 2| 2| 1| 3| 3| 3| 4| 2| 3| 3| 8| 4| 3| 3| 2| 2| 3| 3| 3| 2| 3| 2| 3| 2| |
| 3| 1| 9| 7| 0| 1| 0| 2| 5| 0| 1| 5| 1| 1| 0| 9| 4| 0| 1| 1| 9| 0| 9| 0| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
0.25% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Angiectasis | 3 | 1 3.0|
Atrophy | | 1 4.0|
Degeneration, Cystic | 2 | 2 2.0|
Hyperplasia | 2 2 2 1 1 3 2 2 2 2 2 2 2 | 24 1.9|
Hypertrophy | 2 2 1 1 2 | 14 1.9|
Necrosis | | 2 2.5|
|__________________________________________________________________________|____________|
Adrenal Medulla | + A + A + + + + + + + + + + + + A + + + + + + + +| 47 |
Hyperplasia | 2 2 | 8 1.4|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + A + + + + + + + + + + + + + + A + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + A + M + + + + + +| 47 |
|__________________________________________________________________________|____________|
Pituitary Gland | + A + A + + + + + + + + I + + + + + + + + + + + +| 45 |
Cyst | 1 | 1 1.0|
Pars Distalis, Hyperplasia | 2 4 2 2 | 15 2.3|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + A + + + + + + + + + + + + A + + + + + + + +| 45 |
C-Cell, Hyperplasia | 2 2 3 2 2 1 2 1 1 1 1 2 2 3 1 1 3 3 1| 36 1.7|
Follicular Cell, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | M + + + + + + + + + + + + + + + A + + + + + + + +| 44 |
Hyperplasia | 3 1 | 2 2.0|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 3 | 6 2.8|
|__________________________________________________________________________|____________|
Uterus | + A + + + + + + + + + + + + + + A + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 4| 7| 7| 7| 5| 4| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 8| 2| 2| 1| 3| 3| 3| 4| 2| 3| 3| 8| 4| 3| 3| 2| 2| 3| 3| 3| 2| 3| 2| 3| 2| |
| 3| 1| 9| 7| 0| 1| 0| 2| 5| 0| 1| 5| 1| 1| 0| 9| 4| 0| 1| 1| 9| 0| 9| 0| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
0.25% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Vagina | + | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + A + A + + + + + + + + + + + + A + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Lymph Node | + + + + + | 11 |
Mediastinal, Ectasia | 2 | 1 2.0|
Mediastinal, Infiltration Cellular, | | |
Plasma Cell | | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M M M M M + + M M M M M + M M M + + M M M M M| 12 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + A + A + + + + + + + + + + + + A + + + + + + + +| 47 |
Ectasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Spleen | + A + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hematopoietic Cell Proliferation | 3 3 2| 7 2.9|
Inflammation, Granulomatous | | 1 3.0|
Necrosis | | 1 2.0|
|__________________________________________________________________________|____________|
Thymus | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
Galactocele | 2 | 3 2.3|
Inflammation, Chronic | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 4| 7| 7| 7| 5| 4| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 8| 2| 2| 1| 3| 3| 3| 4| 2| 3| 3| 8| 4| 3| 3| 2| 2| 3| 3| 3| 2| 3| 2| 3| 2| |
| 3| 1| 9| 7| 0| 1| 0| 2| 5| 0| 1| 5| 1| 1| 0| 9| 4| 0| 1| 1| 9| 0| 9| 0| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
0.25% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM - cont | | |
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Osteopetrosis | 3 3 | 3 2.7|
|__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Gliosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 47 1.0|
Inflammation, Chronic Active | 1 1 1 | 4 1.0|
Metaplasia, Osseous | | 1 1.0|
Alveolar Epithelium, Hyperplasia | 1 1 1 1 1 1 1 1 1| 15 1.1|
Bronchiole, Hyperplasia | 1 | 2 2.0|
|__________________________________________________________________________|____________|
Nose | + A + + + + + + + + + + + + + + A + + + + + + + +| 48 |
Inflammation, Suppurative | 4 2 | 5 2.0|
Thrombosis | 2 | 4 2.3|
Respiratory Epithelium, Accumulation,| | |
Hyaline Droplet | 4 1 2 4 4 2 2 4 3 2 1 2 3 3 3 2 1 | 36 2.1|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + A + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | | 1 |
Inflammation, Chronic Active | | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 4| 7| 7| 7| 5| 4| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 8| 2| 2| 1| 3| 3| 3| 4| 2| 3| 3| 8| 4| 3| 3| 2| 2| 3| 3| 3| 2| 3| 2| 3| 2| |
| 3| 1| 9| 7| 0| 1| 0| 2| 5| 0| 1| 5| 1| 1| 0| 9| 4| 0| 1| 1| 9| 0| 9| 0| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
0.25% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
Kidney | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hydronephrosis | 2 | 1 2.0|
Infarct | 2 | 2 2.0|
Inflammation, Suppurative | 2 | 1 2.0|
Nephropathy | 2 2 2 1 2 2 1 1 1 2 1 1 1 1 2 2 2 1 1 1 1 1| 45 1.4|
Pelvis, Inflammation, Acute | 2 | 1 2.0|
Transitional Epithelium, Hyperplasia | | 1 1.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + A + + + + + + + + + + + + + + A + + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 2| 3| 2| 3| 3| 3| 2| 3| 3| 9| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3|
| 0| 1| 0| 9| 1| 9| 0| 1| 1| 9| 1| 1| 8| 0| 1| 0| 0| 0| 0| 0| 1| 1| 1| 1| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X X X X X |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X X X X X X X X |
Eosinophilic Focus | X|
Fatty Change | 2 |
Hepatodiaphragmatic Nodule | X X |
Inflammation, Focal, Granulomatous | 2 1 1 1 1 2 1 2 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 |
Inflammation, Focal, Histiocytic | 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 2 1 1 1 |
Mixed Cell Focus | X X X X |
Bile Duct, Hyperplasia | 1 2|
Centrilobular, Necrosis | 1|
|__________________________________________________________________________|
Mesentery | + + + + + |
Fat, Necrosis | 3 2 2 3 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 2 1 |
Basophilic Focus | X X X |
Hyperplasia | 1 2 2 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 24
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 2| 3| 2| 3| 3| 3| 2| 3| 3| 9| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3|
| 0| 1| 0| 9| 1| 9| 0| 1| 1| 9| 1| 1| 8| 0| 1| 0| 0| 0| 0| 0| 1| 1| 1| 1| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Atrophy | 1 1 |
Basophilic Focus | X X X |
Inflammation, Suppurative | |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | |
Ulcer | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + A + + + + +|
Necrosis | |
|__________________________________________________________________________|
Tongue | |
|__________________________________________________________________________|
Tooth | + |
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 2 1 1 1 1 1 1 1 1 2 2 1 1 1 1 1 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + A + + + + +|
Angiectasis | |
Hyperplasia | 2 3 2 2 2 2 2 1 2 2 2 2 3 2 2|
Hypertrophy | 2 2 2 2 2|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + A + + + + +|
Hyperplasia | 2 3 1 2 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Pars Distalis, Hyperplasia | 4 1 2 2 2 1 2 2 1 2 4 4 |
__________________________________________|__________________________________________________________________________|
Page 25
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 2| 3| 2| 3| 3| 3| 2| 3| 3| 9| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3|
| 0| 1| 0| 9| 1| 9| 0| 1| 1| 9| 1| 1| 8| 0| 1| 0| 0| 0| 0| 0| 1| 1| 1| 1| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + A + + + + +|
C-Cell, Hyperplasia | 2 2 2 2 2 1 2 2 1 1 2 1 1 1 1 1 2 1 1 1 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 3 3 3 4|
Interstitial Cell, Hyperplasia | 3 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + + +|
Deep Cervical, Ectasia | 2 1 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + M M M + M + M M M M M M + M M M + M M M M M M M|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | |
Hematopoietic Cell Proliferation | 2 |
Inflammation, Granulomatous | 4 |
Necrosis | |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 26
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 2| 3| 2| 3| 3| 3| 2| 3| 3| 9| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3|
| 0| 1| 0| 9| 1| 9| 0| 1| 1| 9| 1| 1| 8| 0| 1| 0| 0| 0| 0| 0| 1| 1| 1| 1| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Meninges, Fibrosis | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst, Squamous | |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Inflammation, Chronic Active | 1 1 1 1|
Metaplasia, Squamous | 2 |
Alveolar Epithelium, Hyperplasia | 2 1 4 1 1 1 1 1 1 1 2|
Bronchiole, Hyperplasia | 1 1 1 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + A + + + + +|
Inflammation, Suppurative | 1 1 1 1|
Olfactory Epithelium, Atrophy | 1|
Olfactory Epithelium, Metaplasia | |
Olfactory Epithelium, Metaplasia, | |
Squamous | 4 |
Respiratory Epithelium, Accumulation,| |
Hyaline Droplet | 2 1 1 2 2 2 2 2 1 2 1 2 3 2 1 2 2 2 |
Respiratory Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________|__________________________________________________________________________|
Page 27
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 2| 3| 2| 3| 3| 3| 2| 3| 3| 9| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3|
| 0| 1| 0| 9| 1| 9| 0| 1| 1| 9| 1| 1| 8| 0| 1| 0| 0| 0| 0| 0| 1| 1| 1| 1| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + |
Cataract | 2 4 |
Retina, Atrophy | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Infarct | |
Nephropathy | 1 2 2 1 1 1 1 2 1 1 2 1 1 2 1 1 1 1 1 2 1 2 1 1|
Pelvis, Inflammation, Acute | 3 |
Transitional Epithelium, Hyperplasia | 1 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 28
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
__________________________________________________________________________________________________________________________________
| 6| 7| 5| 2| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 6| 3| 9| 9| 3| 0| 3| 3| 2| 3| 3| 3| 3| 3| 1| 6| 8| 3| 3| 3| 2| 3| 2| 2| 2| |
| 7| 0| 7| 5| 1| 4| 1| 0| 9| 0| 0| 0| 8| 0| 7| 5| 1| 0| 1| 1| 9| 0| 5| 9| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
1.0% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + A + + A + + + + + + + + +| 48 |
Parasite Metazoan | X | 1 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + A + + + + + + + + +| 49 |
Parasite Metazoan | X X X X X X | 13 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + A + + + + + + + + A + + A + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + A + + + + + + + + A + + A + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + A + + + + + + + + A + + A + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A + + + + + + + + A + + A + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X X X| 49 |
Clear Cell Focus | X X X X X X X | 20 |
Eosinophilic Focus | | 1 |
Fatty Change | 2 1 1 2 2| 6 1.7|
Hepatodiaphragmatic Nodule | X X X X | 6 |
Inflammation, Focal, Granulomatous | 1 1 1 1 1 1 1 1 1 2 1 1 1 1 | 37 1.1|
Inflammation, Focal, Histiocytic | 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 | 36 1.1|
Mixed Cell Focus | X X X | 7 |
Bile Duct, Hyperplasia | 1 1 1 1 1 | 7 1.1|
Centrilobular, Necrosis | 1 | 2 1.0|
|__________________________________________________________________________|____________|
Mesentery | + + + + + + + + | 13 |
Fat, Necrosis | 2 2 2 2 2 2 2 | 11 2.2|
|__________________________________________________________________________|____________|
Pancreas | + + + A + + + + + + + + + + + A + + + + + + + + +| 48 |
Atrophy | 4 1 | 6 1.7|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
__________________________________________________________________________________________________________________________________
| 6| 7| 5| 2| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 6| 3| 9| 9| 3| 0| 3| 3| 2| 3| 3| 3| 3| 3| 1| 6| 8| 3| 3| 3| 2| 3| 2| 2| 2| |
| 7| 0| 7| 5| 1| 4| 1| 0| 9| 0| 0| 0| 8| 0| 7| 5| 1| 0| 1| 1| 9| 0| 5| 9| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
1.0% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Basophilic Focus | | 3 |
Hyperplasia | 2 | 4 1.8|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 | 3 1.0|
Basophilic Focus | X X | 5 |
Inflammation, Suppurative | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Squamous | 1 1 1 | 3 1.0|
Ulcer | 3 3| 2 3.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Necrosis | 2 1 | 2 1.5|
|__________________________________________________________________________|____________|
Tongue | + | 1 |
|__________________________________________________________________________|____________|
Tooth | | 1 |
Inflammation, Chronic Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 2 1 1 1 1 2 1 2 1 1 1 1 | 32 1.3|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + A + + + + + + + + + + + A + + + + + + + + +| 47 |
Angiectasis | 3 | 1 3.0|
Hyperplasia | 1 2 2 2 2 3 2 1 2 2 | 25 2.0|
Hypertrophy | 1 2 1 3 2 3 1 | 12 1.9|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + A + + + + + + + + M + + A + + + + + + + + +| 46 |
Hyperplasia | 2 2 1 2 1 2 | 10 1.8|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
__________________________________________________________________________________________________________________________________
| 6| 7| 5| 2| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 6| 3| 9| 9| 3| 0| 3| 3| 2| 3| 3| 3| 3| 3| 1| 6| 8| 3| 3| 3| 2| 3| 2| 2| 2| |
| 7| 0| 7| 5| 1| 4| 1| 0| 9| 0| 0| 0| 8| 0| 7| 5| 1| 0| 1| 1| 9| 0| 5| 9| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
1.0% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + A + + + + + + + + + + + A + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + A + + + + + + + + + + + + + + M + + + + + +| 47 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 2 | 3 2.3|
Pars Distalis, Hyperplasia | 2 2 1 2 2 2 3 2 2 2| 22 2.1|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + A + + + + + + + + A + + A + + + + + + + + +| 46 |
C-Cell, Hyperplasia | 1 1 2 1 2 2 2 2 1 1 2 1 1 1 1 1 1| 38 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + M + + + + M + + + +| 48 |
Hyperplasia | 3 2 1 | 3 2.0|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + A + + + + + + + + +| 49 |
Cyst | 3 4 | 7 3.1|
Interstitial Cell, Hyperplasia | | 1 3.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Cystic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + A + + + + + + + + + + + A + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Lymph Node | + + + +| 8 |
Deep Cervical, Ectasia | | 2 1.5|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
__________________________________________________________________________________________________________________________________
| 6| 7| 5| 2| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 6| 3| 9| 9| 3| 0| 3| 3| 2| 3| 3| 3| 3| 3| 1| 6| 8| 3| 3| 3| 2| 3| 2| 2| 2| |
| 7| 0| 7| 5| 1| 4| 1| 0| 9| 0| 0| 0| 8| 0| 7| 5| 1| 0| 1| 1| 9| 0| 5| 9| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
1.0% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Lymph Node, Mandibular | M M + M + + + M M + + M M M M M + + M M M M M + M| 14 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + A + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + A + + + + + + + + +| 49 |
Accessory Spleen | X | 1 |
Hematopoietic Cell Proliferation | 3 3 2 | 4 2.5|
Inflammation, Granulomatous | | 1 4.0|
Necrosis | 2| 1 2.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + I + + + + + M + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Osteopetrosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Meninges, Fibrosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst, Squamous | 3 | 1 3.0|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 46 1.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
__________________________________________________________________________________________________________________________________
| 6| 7| 5| 2| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 6| 3| 9| 9| 3| 0| 3| 3| 2| 3| 3| 3| 3| 3| 1| 6| 8| 3| 3| 3| 2| 3| 2| 2| 2| |
| 7| 0| 7| 5| 1| 4| 1| 0| 9| 0| 0| 0| 8| 0| 7| 5| 1| 0| 1| 1| 9| 0| 5| 9| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
1.0% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Inflammation, Chronic Active | 1 1 1 1 | 8 1.0|
Metaplasia, Squamous | | 1 2.0|
Alveolar Epithelium, Hyperplasia | 1 1 1 1 4 1 | 17 1.5|
Bronchiole, Hyperplasia | | 3 1.0|
|__________________________________________________________________________|____________|
Nose | + + + A + + + + + + + + A + + A + + + + + + + + +| 46 |
Inflammation, Suppurative | 1 2 1 | 7 1.1|
Olfactory Epithelium, Atrophy | | 1 1.0|
Olfactory Epithelium, Metaplasia | 2 | 1 2.0|
Olfactory Epithelium, Metaplasia, | | |
Squamous | | 1 4.0|
Respiratory Epithelium, Accumulation,| | |
Hyaline Droplet | 2 1 1 2 2 2 1 2 3 2 3 2 2 3 2 2 2 3 2| 37 1.9|
Respiratory Epithelium, Hyperplasia | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Trachea | + + + A + + + + + + + + A + + A + + + + + + + + +| 46 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | | 2 |
Cataract | | 2 3.0|
Retina, Atrophy | | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + A + + + + + + + + +| 49 |
Cyst | 2 | 1 2.0|
Infarct | 2 | 1 2.0|
Nephropathy | 1 2 1 1 1 2 2 1 2 2 1 1 1 1 1 1 1 1 1 2 1 2 1| 47 1.3|
Pelvis, Inflammation, Acute | | 1 3.0|
Transitional Epithelium, Hyperplasia | | 1 1.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + A + + + + + + + + + + + A + + + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 6| 3| 3| 1| 3| 9| 3| 3| 3| 2| 3| 2| 5| 8| 3| 2| 3| 3| 4| 1| 2| 3|
| 9| 1| 1| 8| 0| 0| 8| 1| 4| 1| 0| 0| 6| 0| 9| 9| 1| 1| 9| 0| 1| 2| 1| 9| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
4.0% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + A + + + + + + A + +|
Parasite Metazoan | X X |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + A + + + + + + A + +|
Parasite Metazoan | X X |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + A + + + + + + A + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + A + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + + + + + + A + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + A + + + + + + + + +|
Necrosis | 1 |
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X X X X X X |
Eosinophilic Focus | X X |
Fatty Change | 2 3 |
Hepatodiaphragmatic Nodule | X X X|
Inflammation, Focal, Granulomatous | 1 1 1 1 2 1 1 2 1 1 1 1 1 1 3|
Inflammation, Focal, Histiocytic | 1 1 1 1 2 1 1 1 1 1 1 1 1 1|
Mixed Cell Focus | X X X |
Bile Duct, Hyperplasia | 1 1 1 1 1 2 1 1 1 |
Centrilobular, Necrosis | 2 1 2 1 |
|__________________________________________________________________________|
Mesentery | + + + + +|
Fat, Necrosis | 2 3 2 2|
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 1 2 2 2 1|
Basophilic Focus | X |
Hyperplasia | 2 2 3 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 34
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 6| 3| 3| 1| 3| 9| 3| 3| 3| 2| 3| 2| 5| 8| 3| 2| 3| 3| 4| 1| 2| 3|
| 9| 1| 1| 8| 0| 0| 8| 1| 4| 1| 0| 0| 6| 0| 9| 9| 1| 1| 9| 0| 1| 2| 1| 9| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
4.0% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Inflammation, Suppurative | 2 |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + A + + + + + + + + +|
Hyperplasia, Squamous | |
Ulcer | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + A + + + + + + + + +|
Mineralization | |
Necrosis | 3 2 |
|__________________________________________________________________________|
Tongue | |
|__________________________________________________________________________|
Tooth | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 2 1 1 2 1 1 1 1 2 1 1 1 2 1 2|
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + A + + + + + + + + +|
Hyperplasia | 1 2 2 2 3 2 1 1 |
Hypertrophy | 2 2 1 2|
Necrosis | 2 3 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + A + + + + + + + + +|
Hyperplasia | 3 2 |
Necrosis | 4 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
__________________________________________|__________________________________________________________________________|
Page 35
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 6| 3| 3| 1| 3| 9| 3| 3| 3| 2| 3| 2| 5| 8| 3| 2| 3| 3| 4| 1| 2| 3|
| 9| 1| 1| 8| 0| 0| 8| 1| 4| 1| 0| 0| 6| 0| 9| 9| 1| 1| 9| 0| 1| 2| 1| 9| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
4.0% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + A + + + + + + + + +|
Angiectasis | 1 |
Cyst | 3 |
Pars Distalis, Hyperplasia | 2 3 2 2 2 2 2 4 2 4 4 1|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + A + + + + + + A + +|
C-Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 2 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Peritoneum | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Inflammation, Chronic Active | 3 |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + A + + + + + + + + +|
Cyst | 2 2 3 3|
Inflammation, Granulomatous | |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + A + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + + + + + + +|
Deep Cervical, Hyperplasia | 2 |
Mediastinal, Ectasia | 2 |
Mediastinal, Infiltration Cellular, | |
Plasma Cell | 3 |
|__________________________________________________________________________|
Lymph Node, Mandibular | M + + M M M + M M M M M M M M M + + + M M M M M M|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 36
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 6| 3| 3| 1| 3| 9| 3| 3| 3| 2| 3| 2| 5| 8| 3| 2| 3| 3| 4| 1| 2| 3|
| 9| 1| 1| 8| 0| 0| 8| 1| 4| 1| 0| 0| 6| 0| 9| 9| 1| 1| 9| 0| 1| 2| 1| 9| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
4.0% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 |
Hemorrhage | 3 |
Inflammation, Granulomatous | 4 4|
|__________________________________________________________________________|
Thymus | + + + + + + + M + + M + + + + A + + + M + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 2 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Inflammation, Chronic Active | 1 1 1 1 1 1 |
Alveolar Epithelium, Hyperplasia | 2 1 3 |
Bronchiole, Hyperplasia | 1 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
Thrombosis | |
__________________________________________|__________________________________________________________________________|
Page 37
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 6| 3| 3| 1| 3| 9| 3| 3| 3| 2| 3| 2| 5| 8| 3| 2| 3| 3| 4| 1| 2| 3|
| 9| 1| 1| 8| 0| 0| 8| 1| 4| 1| 0| 0| 6| 0| 9| 9| 1| 1| 9| 0| 1| 2| 1| 9| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
4.0% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Olfactory Epithelium, Degeneration | 1 2 2 1 3 |
Olfactory Epithelium, Metaplasia | 1 |
Respiratory Epithelium, Accumulation,| |
Hyaline Droplet | 4 3 2 2 3 3 3 3 3 2 3 3 2 2 3 2 2 3 4 2 2 3 2 2|
|__________________________________________________________________________|
Pleura | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + A + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + |
Cataract | 4 |
Degeneration | 4 4 |
Retina, Atrophy | 4 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + A + + + + + + + + +|
Infarct | 2 3 3 2 |
Nephropathy | 3 2 1 1 2 1 4 1 2 2 1 2 2 2 1 2 2 2 1 2 2 2 2 1|
Transitional Epithelium, Hyperplasia | 1 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | 1 |
__________________________________________|__________________________________________________________________________
Page 38
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 5| 5| 7| 7| 5| 7| 5| 6| 5| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| |
DAY ON TEST | 3| 2| 3| 3| 9| 3| 3| 7| 3| 8| 2| 9| 3| 3| 3| 3| 3| 2| 3| 6| 9| 5| 2| 3| 2| |
| 0| 9| 3| 6| 7| 0| 0| 7| 1| 2| 6| 7| 0| 1| 0| 0| 0| 9| 1| 4| 4| 2| 5| 0| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
4.0% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + A + + + + + + A + + + + + + + + + + + + + + +| 46 |
Parasite Metazoan | | 2 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + A + + + + + + A + + + + + + + + + + + + + + +| 46 |
Parasite Metazoan | X | 3 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A + + + + + + A + + + + + + + + + + + A + + +| 45 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A + + + + + + A + + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A + + + + + + A + + + + + + + + + A + A + + +| 44 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + + + + + + A + + + + + + + + + A + A + + +| 45 |
Necrosis | | 1 1.0|
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X| 46 |
Clear Cell Focus | X X X X X X | 17 |
Eosinophilic Focus | X X | 4 |
Fatty Change | 3 3 | 4 2.8|
Hepatodiaphragmatic Nodule | X X X | 6 |
Inflammation, Focal, Granulomatous | 1 2 1 1 1 1 2 1 1 1 1| 26 1.2|
Inflammation, Focal, Histiocytic | 1 1 2 1 2 1 1 1 1 1 1 1 1 1| 28 1.1|
Mixed Cell Focus | X | 4 |
Bile Duct, Hyperplasia | 1 1 1 1 2 1 1 3 1| 18 1.2|
Centrilobular, Necrosis | 1 1 | 6 1.3|
|__________________________________________________________________________|____________|
Mesentery | + + + + + + | 11 |
Fat, Necrosis | 2 2 2 2 | 8 2.1|
|__________________________________________________________________________|____________|
Pancreas | + + A + + + + + + A + + + + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 5| 5| 7| 7| 5| 7| 5| 6| 5| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| |
DAY ON TEST | 3| 2| 3| 3| 9| 3| 3| 7| 3| 8| 2| 9| 3| 3| 3| 3| 3| 2| 3| 6| 9| 5| 2| 3| 2| |
| 0| 9| 3| 6| 7| 0| 0| 7| 1| 2| 6| 7| 0| 1| 0| 0| 0| 9| 1| 4| 4| 2| 5| 0| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
4.0% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Atrophy | 1 1 2 | 10 1.4|
Basophilic Focus | X X | 3 |
Hyperplasia | | 3 2.3|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 2.0|
Inflammation, Suppurative | | 1 2.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 |
Hyperplasia, Squamous | 3 2 | 2 2.5|
Ulcer | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + A + + + + + + A + + + + + + + + + + + + + + +| 47 |
Mineralization | 1 | 1 1.0|
Necrosis | 1 2 | 4 2.0|
|__________________________________________________________________________|____________|
Tongue | + | 1 |
|__________________________________________________________________________|____________|
Tooth | + | 1 |
Inflammation, Chronic Active | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 2 1 1 1 1 1 2 1 | 26 1.3|
Atrium, Thrombosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + A + + + + + + A + + + + + + + + + + + + + + +| 47 |
Hyperplasia | 1 2 1 2 1| 13 1.6|
Hypertrophy | 1 1 3 1 2 | 9 1.7|
Necrosis | | 2 2.5|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 5| 5| 7| 7| 5| 7| 5| 6| 5| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| |
DAY ON TEST | 3| 2| 3| 3| 9| 3| 3| 7| 3| 8| 2| 9| 3| 3| 3| 3| 3| 2| 3| 6| 9| 5| 2| 3| 2| |
| 0| 9| 3| 6| 7| 0| 0| 7| 1| 2| 6| 7| 0| 1| 0| 0| 0| 9| 1| 4| 4| 2| 5| 0| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
4.0% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Adrenal Medulla | + + A + + + + + + A + + + + + + + + + + + + + + +| 47 |
Hyperplasia | 2 2 1 2 1| 7 1.9|
Necrosis | 4 | 2 4.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + A + + + + + + A + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 2 2.0|
|__________________________________________________________________________|____________|
Pituitary Gland | + + A + + + + + + A + + + + + + + + + + + + + + +| 47 |
Angiectasis | 2 | 2 1.5|
Cyst | | 1 3.0|
Pars Distalis, Hyperplasia | 2 1 4 3 4 3 3| 19 2.6|
|__________________________________________________________________________|____________|
Thyroid Gland | + + A + + + + + + A + + + + + + + + + + + + + + +| 46 |
C-Cell, Hyperplasia | 1 1 1 1 2 1 2 1 1 2 1 1 1 1 1 | 28 1.1|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Peritoneum | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + A + + + + + + + + + + + + + M +| 48 |
Hyperplasia | 2 2 | 3 2.0|
Inflammation, Chronic Active | | 1 3.0|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 |
Cyst | 2 2 3 3| 8 2.5|
Inflammation, Granulomatous | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Cystic | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 5| 5| 7| 7| 5| 7| 5| 6| 5| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| |
DAY ON TEST | 3| 2| 3| 3| 9| 3| 3| 7| 3| 8| 2| 9| 3| 3| 3| 3| 3| 2| 3| 6| 9| 5| 2| 3| 2| |
| 0| 9| 3| 6| 7| 0| 0| 7| 1| 2| 6| 7| 0| 1| 0| 0| 0| 9| 1| 4| 4| 2| 5| 0| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
4.0% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + A + + + + + + A + + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + | 14 |
Deep Cervical, Hyperplasia | | 1 2.0|
Mediastinal, Ectasia | | 1 2.0|
Mediastinal, Infiltration Cellular, | | |
Plasma Cell | | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + M M + M M M M A + M M M M M M M M M + + + + +| 14 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + M + + + + + + A + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Spleen | + + A + + + + + + A + + + + + + + + + + + + + + +| 48 |
Hematopoietic Cell Proliferation | 3 | 2 3.5|
Hemorrhage | | 1 3.0|
Inflammation, Granulomatous | 2 | 3 3.3|
|__________________________________________________________________________|____________|
Thymus | + + M + + M + M + A + M + + + M + + + M + + + + +| 39 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + M + + + + + + + + + + + + + + + + + + + + + +| 49 |
Galactocele | | 1 2.0|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 2 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Osteopetrosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 5| 5| 7| 7| 5| 7| 5| 6| 5| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| |
DAY ON TEST | 3| 2| 3| 3| 9| 3| 3| 7| 3| 8| 2| 9| 3| 3| 3| 3| 3| 2| 3| 6| 9| 5| 2| 3| 2| |
| 0| 9| 3| 6| 7| 0| 0| 7| 1| 2| 6| 7| 0| 1| 0| 0| 0| 9| 1| 4| 4| 2| 5| 0| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
4.0% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 45 1.0|
Inflammation, Chronic Active | 1 1 1 1 1 | 11 1.0|
Alveolar Epithelium, Hyperplasia | 1 1 1 1 1 | 8 1.4|
Bronchiole, Hyperplasia | 1 | 2 1.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 2 2 2 | 4 2.0|
Thrombosis | 2 1 2 | 3 1.7|
Olfactory Epithelium, Degeneration | 3 3 3 4 | 9 2.4|
Olfactory Epithelium, Metaplasia | | 1 1.0|
Respiratory Epithelium, Accumulation,| | |
Hyaline Droplet | 2 3 2 2 2 1 2 2 3 2 4 3 2 2 3 2 2 2 2 3 4 4| 46 2.5|
|__________________________________________________________________________|____________|
Pleura | + | 1 |
|__________________________________________________________________________|____________|
Trachea | + + A + + + + + + A + + + + + + + + + + + + + + +| 47 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | | 3 |
Cataract | | 1 4.0|
Degeneration | | 2 4.0|
Retina, Atrophy | | 2 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + A + + + + + + A + + + + + + + + + + + + + + +| 47 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 5| 5| 7| 7| 5| 7| 5| 6| 5| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| |
DAY ON TEST | 3| 2| 3| 3| 9| 3| 3| 7| 3| 8| 2| 9| 3| 3| 3| 3| 3| 2| 3| 6| 9| 5| 2| 3| 2| |
| 0| 9| 3| 6| 7| 0| 0| 7| 1| 2| 6| 7| 0| 1| 0| 0| 0| 9| 1| 4| 4| 2| 5| 0| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
4.0% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
Infarct | | 4 2.5|
Nephropathy | 2 1 1 2 1 1 3 2 4 2 2 2 2 2 2 2 1 2 2 2 2 2| 46 1.8|
Transitional Epithelium, Hyperplasia | | 1 1.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + A I + + + + + A + + + + + + + + + A + + + + +| 46 |
Transitional Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 6| 7| 7| 5| 5| 5| 3| 7| 6| 5| 5| 5| 6| 6| 7| 7| 7| 6| 6| 7|
DAY ON TEST | 3| 3| 5| 2| 2| 9| 2| 2| 8| 6| 6| 7| 3| 9| 1| 6| 6| 7| 5| 2| 2| 2| 3| 7| 2|
| 0| 0| 3| 9| 9| 8| 9| 9| 2| 5| 8| 6| 0| 7| 1| 9| 4| 9| 3| 9| 9| 9| 6| 3| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + A + + + + + A + + A + + + + + A +|
Parasite Metazoan | X X |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + A + + + + + A + + + + + + + A A +|
Parasite Metazoan | X X |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + A + + + + + A A + A + + + + A A +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + A + + + + + A A + A + + + + + A +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A + + + + A A A + A + + + + A A +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A + + + + A A A + A + + + + A A +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X X X X X X X|
Degeneration, Cystic | 1 2 2 |
Eosinophilic Focus | |
Fatty Change | 1 |
Hepatodiaphragmatic Nodule | X |
Inflammation, Focal, Granulomatous | 1 1 1 1 1 1 1 1 1 1 1 1|
Inflammation, Focal, Histiocytic | 1 1 1 1 1 1 1 2 1 1 1 1|
Regeneration | 2 2 |
Thrombosis | |
Bile Duct, Hyperplasia | 1 1 2 1 1 1 1 2 2 1 3 1 3 1 1 2 3 |
Centrilobular, Necrosis | 2 2 1 1 3 3 2 |
|__________________________________________________________________________|
Mesentery | + + + + + + + |
Fat, Inflammation | 3 |
Fat, Necrosis | 2 2 2 3 2 2 2 |
|__________________________________________________________________________|
Oral Mucosa | |
Pharyngeal, Necrosis | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 45
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 6| 7| 7| 5| 5| 5| 3| 7| 6| 5| 5| 5| 6| 6| 7| 7| 7| 6| 6| 7|
DAY ON TEST | 3| 3| 5| 2| 2| 9| 2| 2| 8| 6| 6| 7| 3| 9| 1| 6| 6| 7| 5| 2| 2| 2| 3| 7| 2|
| 0| 0| 3| 9| 9| 8| 9| 9| 2| 5| 8| 6| 0| 7| 1| 9| 4| 9| 3| 9| 9| 9| 6| 3| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Pancreas | + + + + + + + + A + + + + + A + + + + + + + A A +|
Atrophy | 3 2 1 1 3 2 2 |
Basophilic Focus | |
Hyperplasia | 2 2 |
Artery, Inflammation | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Basophilic Focus | X |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Diffuse, Squamous | 2 |
Ulcer | 2 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + A + + + + + A + + + + + + + + A +|
Necrosis | 2 |
|__________________________________________________________________________|
Tooth | + |
Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + |
Inflammation, Granulomatous | 1 |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 3 2 3 2 1 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + A +|
Degeneration, Cystic | 2 |
Hyperplasia | 2 2 1 2 2 2 1 2 1 2|
Hypertrophy | 2 3 2 1 |
Necrosis | 2 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________|__________________________________________________________________________|
Page 46
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 6| 7| 7| 5| 5| 5| 3| 7| 6| 5| 5| 5| 6| 6| 7| 7| 7| 6| 6| 7|
DAY ON TEST | 3| 3| 5| 2| 2| 9| 2| 2| 8| 6| 6| 7| 3| 9| 1| 6| 6| 7| 5| 2| 2| 2| 3| 7| 2|
| 0| 0| 3| 9| 9| 8| 9| 9| 2| 5| 8| 6| 0| 7| 1| 9| 4| 9| 3| 9| 9| 9| 6| 3| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Hyperplasia | 2 3 3 1 1 3 4 3 3 1 |
Necrosis | 2 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + A + + + + + A + + + + + + + A A +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + A +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + A + + + + + + + A +|
Angiectasis | |
Pars Distalis, Hyperplasia | 3 2 1 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + A + + + + + A + + A + + + + + A +|
C-Cell, Hyperplasia | 1 2 1 1 2 1 1 2 1 1|
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Peritoneum | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Prostate | + + + + + + + + A + + + + + + + + + + + + + + A +|
Hyperplasia | 4 3 2 1 |
Inflammation, Chronic Active | 2 2 3 2 |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + A + + + + + + A + + + + + + A A +|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Interstitial Cell, Hyperplasia | 2 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 47
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 6| 7| 7| 5| 5| 5| 3| 7| 6| 5| 5| 5| 6| 6| 7| 7| 7| 6| 6| 7|
DAY ON TEST | 3| 3| 5| 2| 2| 9| 2| 2| 8| 6| 6| 7| 3| 9| 1| 6| 6| 7| 5| 2| 2| 2| 3| 7| 2|
| 0| 0| 3| 9| 9| 8| 9| 9| 2| 5| 8| 6| 0| 7| 1| 9| 4| 9| 3| 9| 9| 9| 6| 3| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Bone Marrow | + + + + + + + + + + + + + + A + + + + + + + + A +|
|__________________________________________________________________________|
Lymph Node | + + + + + + + + |
Mediastinal, Ectasia | 2 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + M M M M + M M M M + M M + M M + M M + + M M M M|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + A + + + + + A + + + + + + + + M +|
|__________________________________________________________________________|
Spleen | + + + + + + + + A + + + + + A A + + + + + + A A +|
Atrophy | |
Congestion | 3 |
Fibrosis | 1 1 |
Hematopoietic Cell Proliferation | 2 |
Hemorrhage | 2 |
Hyperplasia, Focal, Lymphoid | 2 2|
|__________________________________________________________________________|
Thymus | + + + + + + M + I + + + M M + + M + M + + + + A +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | M + + + + + + + + + + + + + + + + + + + + + + M +|
Galactocele | 2 |
|__________________________________________________________________________|
Skin | + + + + + + + + M + + + + + + + + + + + + + + + +|
Cyst | 3 |
Hyperkeratosis | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 48
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 6| 7| 7| 5| 5| 5| 3| 7| 6| 5| 5| 5| 6| 6| 7| 7| 7| 6| 6| 7|
DAY ON TEST | 3| 3| 5| 2| 2| 9| 2| 2| 8| 6| 6| 7| 3| 9| 1| 6| 6| 7| 5| 2| 2| 2| 3| 7| 2|
| 0| 0| 3| 9| 9| 8| 9| 9| 2| 5| 8| 6| 0| 7| 1| 9| 4| 9| 3| 9| 9| 9| 6| 3| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM - cont | |
Peripheral Nerve | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Inflammation, Chronic Active | 2 1 |
Metaplasia, Squamous | 1 |
Alveolar Epithelium, Hyperplasia | 1 2 1 4 1 2 1 |
Mediastinum, Necrosis, Fatty | |
|__________________________________________________________________________|
Nose | + + + + + + + + A + + + + + + + + + + + + + + A +|
Inflammation, Suppurative | 2 1 1 2 3 |
Thrombosis | |
Olfactory Epithelium, Atrophy | 1 1 2 |
Olfactory Epithelium, Metaplasia | 3 |
|__________________________________________________________________________|
Trachea | + + + + + + + + A + + + + + A A + + + + + + + A +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + |
Cataract | 3 |
Retina, Atrophy | |
|__________________________________________________________________________|
Zymbal's Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + A + + + + + + + + + + + + + + A +|
Infarct | 3 4 |
Nephropathy | 2 2 2 3 3 2 2 2 2 1 2 2 1 2 1 2 3 2 3 2 2|
Pigmentation | |
Transitional Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + A + + + + + + + + A + + + + + A +|
__________________________________________|__________________________________________________________________________
Page 49
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 3| 7| 6| 6| 7| 6| 7| 2| 7| 7| 5| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 1| 6| 9| 1| 2| 2| 8| 7| 3| 4| 3| 6| 2| 2| 8| 2| 5| 3| 6| 2| 2| 3| 9| 2| 2| |
| 8| 7| 7| 7| 3| 9| 7| 6| 0| 5| 0| 1| 9| 9| 4| 9| 4| 0| 4| 9| 9| 0| 8| 9| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0.0% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + A A + A A + A + + + + + + + + + + + + + + +| 41 |
Parasite Metazoan | X X | 4 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + A A + A A + A + + + I + + + + + + + + + + +| 40 |
Parasite Metazoan | X X X X | 6 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + A A + A A + A + A + + + + + + + + + + + + +| 38 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + A A + A A + A + A + + + + + + + + + + + + +| 39 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + A A + A A + A + A + + + + + + + + + + + + +| 37 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A A + A A + A + A + + + + + + + + + + + + +| 37 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X| 24 |
Clear Cell Focus | X X X X X X X X X X| 22 |
Degeneration, Cystic | 2 | 4 1.8|
Eosinophilic Focus | X | 1 |
Fatty Change | 2 2 3 1 2 | 6 1.8|
Hepatodiaphragmatic Nodule | X X | 3 |
Inflammation, Focal, Granulomatous | 2 1 1 1 1 1 1 1 1 1| 22 1.0|
Inflammation, Focal, Histiocytic | 1 1 1 1 1 1 | 18 1.1|
Regeneration | 2 | 3 2.0|
Thrombosis | 1 | 1 1.0|
Bile Duct, Hyperplasia | 1 2 1 1 2 2 2 1 1 1 1 2 1 1 3 2 1 | 34 1.5|
Centrilobular, Necrosis | 1 1 2 3 3 1 1 2 | 15 1.9|
|__________________________________________________________________________|____________|
Mesentery | + + + + + + + | 14 |
Fat, Inflammation | | 1 3.0|
Fat, Necrosis | 2 2 2 2 3 | 12 2.2|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 3| 7| 6| 6| 7| 6| 7| 2| 7| 7| 5| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 1| 6| 9| 1| 2| 2| 8| 7| 3| 4| 3| 6| 2| 2| 8| 2| 5| 3| 6| 2| 2| 3| 9| 2| 2| |
| 8| 7| 7| 7| 3| 9| 7| 6| 0| 5| 0| 1| 9| 9| 4| 9| 4| 0| 4| 9| 9| 0| 8| 9| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0.0% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Oral Mucosa | +| 1 |
Pharyngeal, Necrosis | 2| 1 2.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + A + A + + + + + + + + + + + + + + +| 44 |
Atrophy | 2 2 2 1 2 2 1 1 2 2| 17 1.8|
Basophilic Focus | X | 1 |
Hyperplasia | 2 2 2 2 2 | 7 2.0|
Artery, Inflammation | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Salivary Glands | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 2 | 1 2.0|
Basophilic Focus | | 1 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Diffuse, Squamous | 2 | 2 2.0|
Ulcer | 2 3 | 3 2.3|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + A + + + + + + + + + + + + +| 46 |
Necrosis | 1 1 4 2 | 5 2.0|
|__________________________________________________________________________|____________|
Tooth | | 1 |
Inflammation, Chronic Active | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Inflammation, Granulomatous | | 1 1.0|
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 1 2 1 2 1 2 2 2 1 1 2 2 2 3 2 2 1 2| 41 1.9|
Hemorrhage | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 3| 7| 6| 6| 7| 6| 7| 2| 7| 7| 5| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 1| 6| 9| 1| 2| 2| 8| 7| 3| 4| 3| 6| 2| 2| 8| 2| 5| 3| 6| 2| 2| 3| 9| 2| 2| |
| 8| 7| 7| 7| 3| 9| 7| 6| 0| 5| 0| 1| 9| 9| 4| 9| 4| 0| 4| 9| 9| 0| 8| 9| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0.0% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + A + + A + + + + + + + + + + + + + + +| 47 |
Degeneration, Cystic | | 1 2.0|
Hyperplasia | 1 2 2 2 2| 15 1.7|
Hypertrophy | 2| 5 2.0|
Necrosis | | 1 2.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + A + + A + + + + + + + + + + + + + + +| 47 |
Hyperplasia | 2 3 2 4 1 3 3 3 1 4 1 3 2 | 23 2.4|
Necrosis | | 1 2.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + A + A + + + + + + + + + + + + + + +| 44 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + A + M M + + + + + M + + + + + + + + + + +| 45 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + A + + + + + + + + + + + + + + + + + + + +| 47 |
Angiectasis | 2 | 1 2.0|
Pars Distalis, Hyperplasia | 2 1 3 1 2 3| 9 2.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + A A + + + + A + A + + + + + + + + + + + + +| 42 |
C-Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 24 1.1|
Follicular Cell, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Peritoneum | + + + | 3 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 1 1.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 3| 7| 6| 6| 7| 6| 7| 2| 7| 7| 5| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 1| 6| 9| 1| 2| 2| 8| 7| 3| 4| 3| 6| 2| 2| 8| 2| 5| 3| 6| 2| 2| 3| 9| 2| 2| |
| 8| 7| 7| 7| 3| 9| 7| 6| 0| 5| 0| 1| 9| 9| 4| 9| 4| 0| 4| 9| 9| 0| 8| 9| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0.0% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 1 2 4 1 4 2 1 | 11 2.3|
Inflammation, Chronic Active | 2 2 2 3 | 8 2.3|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + A + + A + + + + A + + + + + + + + + + + + +| 43 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 | 2 3.5|
Interstitial Cell, Hyperplasia | | 3 1.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + A + A + + + + + + + + + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 18 |
Mediastinal, Ectasia | 3 | 2 2.5|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M + M M M M + A M M M + M + M + + M M M M M M| 13 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + A + + M + A + + + + + + + + + + + + + + +| 44 |
|__________________________________________________________________________|____________|
Spleen | + + + + A + A + + + + + + + + + + + + + + + + + +| 43 |
Atrophy | 2 | 1 2.0|
Congestion | | 1 3.0|
Fibrosis | 2 2 2 2 | 6 1.7|
Hematopoietic Cell Proliferation | 2 | 2 2.0|
Hemorrhage | 3 | 2 2.5|
Hyperplasia, Focal, Lymphoid | 2 2 | 4 2.0|
|__________________________________________________________________________|____________|
Thymus | M + + + A + + + + M + + + + + + + + + M + + + + +| 39 |
Hemorrhage | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 3| 7| 6| 6| 7| 6| 7| 2| 7| 7| 5| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 1| 6| 9| 1| 2| 2| 8| 7| 3| 4| 3| 6| 2| 2| 8| 2| 5| 3| 6| 2| 2| 3| 9| 2| 2| |
| 8| 7| 7| 7| 3| 9| 7| 6| 0| 5| 0| 1| 9| 9| 4| 9| 4| 0| 4| 9| 9| 0| 8| 9| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0.0% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Galactocele | | 1 2.0|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + I + + + + + + + + + + + + +| 48 |
Cyst | | 1 3.0|
Hyperkeratosis | 4 | 1 4.0|
Inflammation, Chronic Active | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 1 2.0|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 32 1.0|
Inflammation, Chronic Active | 1 | 3 1.3|
Metaplasia, Squamous | | 1 1.0|
Alveolar Epithelium, Hyperplasia | 4 1 2 2| 11 1.9|
Mediastinum, Necrosis, Fatty | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + A + A + + + + + + + + + + + + +| 46 |
Inflammation, Suppurative | 3 2 2 1 3 2| 11 2.0|
Thrombosis | 2 4 | 2 3.0|
Olfactory Epithelium, Atrophy | 1 | 4 1.3|
Olfactory Epithelium, Metaplasia | 2 1 2 | 4 2.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 3| 7| 6| 6| 7| 6| 7| 2| 7| 7| 5| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 1| 6| 9| 1| 2| 2| 8| 7| 3| 4| 3| 6| 2| 2| 8| 2| 5| 3| 6| 2| 2| 3| 9| 2| 2| |
| 8| 7| 7| 7| 3| 9| 7| 6| 0| 5| 0| 1| 9| 9| 4| 9| 4| 0| 4| 9| 9| 0| 8| 9| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0.0% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Trachea | + + + + A + + + + A + A + + + + + + + + + + + + +| 43 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + | 2 |
Cataract | 4 | 2 3.5|
Retina, Atrophy | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Zymbal's Gland | + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + A + + + + + + + + + + + + + + +| 47 |
Infarct | 2 | 3 3.0|
Nephropathy | 2 3 2 2 2 3 1 2 2 1 3 3 3 2 2 3 2 2 2 2| 41 2.1|
Pigmentation | 2 | 1 2.0|
Transitional Epithelium, Hyperplasia | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + A + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7| 6| 7| 4| 7| 7| 7| 6| 6| 5| 7|
DAY ON TEST | 2| 2| 3| 0| 1| 3| 2| 8| 4| 3| 2| 2| 5| 2| 2| 9| 3| 5| 3| 2| 2| 4| 6| 6| 2|
| 9| 9| 0| 9| 7| 0| 9| 0| 9| 0| 9| 6| 0| 9| 9| 8| 0| 6| 0| 9| 9| 9| 1| 4| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.25% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
Ulcer | |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + + + + + A + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + A + + + + A + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X X X X X|
Degeneration, Cystic | 2 |
Fatty Change | 3 1 |
Hepatodiaphragmatic Nodule | X X X X X |
Inflammation, Focal, Granulomatous | 1 1 1 1 1 1 1 1 1 1 1 1|
Inflammation, Focal, Histiocytic | 1 1 1 1 1 1 2 1 1 1|
Mixed Cell Focus | X |
Vacuolization Cytoplasmic, Focal | 2 |
Bile Duct, Hyperplasia | 2 1 1 2 1 1 1 2 2 1 2 1 1 1 1 2 2 1 3 2 1|
Centrilobular, Necrosis | 1 1 2 1 3 2 2 |
|__________________________________________________________________________|
Mesentery | + + + + + + + |
Fat, Necrosis | 2 2 2 2 3 2 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + M + + + + + + + + + + + +|
Atrophy | 2 4 2 2 2 1 |
Basophilic Focus | X |
__________________________________________|__________________________________________________________________________|
Page 56
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7| 6| 7| 4| 7| 7| 7| 6| 6| 5| 7|
DAY ON TEST | 2| 2| 3| 0| 1| 3| 2| 8| 4| 3| 2| 2| 5| 2| 2| 9| 3| 5| 3| 2| 2| 4| 6| 6| 2|
| 9| 9| 0| 9| 7| 0| 9| 0| 9| 0| 9| 6| 0| 9| 9| 8| 0| 6| 0| 9| 9| 9| 1| 4| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.25% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Hyperplasia | 3 2 4 2 |
Thrombosis | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 |
Basophilic Focus | X |
Inflammation, Suppurative | |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Hyperplasia, Squamous | |
Ulcer | 2 3 2 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia | |
Mineralization | 2 |
Necrosis | 2 3 2 2 |
|__________________________________________________________________________|
Tongue | +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 3 1 2 2 3 1 2 2 2 2 1 2 1 2 2 2 1 1|
Atrium, Thrombosis | 3 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 1 2 2 2 1 2 2 2 1|
Hypertrophy | 2 2 2 |
Inflammation, Granulomatous | |
Necrosis | 2 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 4 1 3 3 2 1 3 1 4 2 1 3 2|
__________________________________________|__________________________________________________________________________|
Page 57
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7| 6| 7| 4| 7| 7| 7| 6| 6| 5| 7|
DAY ON TEST | 2| 2| 3| 0| 1| 3| 2| 8| 4| 3| 2| 2| 5| 2| 2| 9| 3| 5| 3| 2| 2| 4| 6| 6| 2|
| 9| 9| 0| 9| 7| 0| 9| 0| 9| 0| 9| 6| 0| 9| 9| 8| 0| 6| 0| 9| 9| 9| 1| 4| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.25% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + M + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 3 3 |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 |
Pars Distalis, Hyperplasia | 2 3 2 1 3 2 1 2 2 2 2 |
|__________________________________________________________________________|
Thyroid Gland | + + + A + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 3 2 1 1 2 1 2 1 1 1 2 2|
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Peritoneum | + |
|__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
Hyperplasia | 1 2 |
Inflammation, Chronic Active | |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 1 3 4 1 3|
Inflammation, Chronic Active | 2 3 2 2 |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Interstitial Cell, Hyperplasia | 2 |
__________________________________________|__________________________________________________________________________|
Page 58
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7| 6| 7| 4| 7| 7| 7| 6| 6| 5| 7|
DAY ON TEST | 2| 2| 3| 0| 1| 3| 2| 8| 4| 3| 2| 2| 5| 2| 2| 9| 3| 5| 3| 2| 2| 4| 6| 6| 2|
| 9| 9| 0| 9| 7| 0| 9| 0| 9| 0| 9| 6| 0| 9| 9| 8| 0| 6| 0| 9| 9| 9| 1| 4| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.25% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + |
|__________________________________________________________________________|
Lymph Node, Mandibular | M M M M M M M M + + + M M M M + M + + M + M + M M|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Granulomatous | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 2 2 3 2 |
Hematopoietic Cell Proliferation | 3 3 |
Hyperplasia, Focal, Lymphoid | 4 2 3 |
Necrosis | 2 |
|__________________________________________________________________________|
Thymus | + + + + + + + + M + + + + + + + + + + + + + + + +|
Atrophy | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + M + M + + + + + + +|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + I + + I + + + + + + + +|
Foreign Body | |
Hyperkeratosis | 3 3 |
Hyperplasia, Basal Cell | 1 |
Inflammation, Chronic Active | |
Prepuce, Inflammation, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 2 |
__________________________________________|__________________________________________________________________________|
Page 59
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7| 6| 7| 4| 7| 7| 7| 6| 6| 5| 7|
DAY ON TEST | 2| 2| 3| 0| 1| 3| 2| 8| 4| 3| 2| 2| 5| 2| 2| 9| 3| 5| 3| 2| 2| 4| 6| 6| 2|
| 9| 9| 0| 9| 7| 0| 9| 0| 9| 0| 9| 6| 0| 9| 9| 8| 0| 6| 0| 9| 9| 9| 1| 4| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.25% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Inflammation, Chronic Active | 2 |
Metaplasia, Squamous | 2|
Mineralization | 2 |
Thrombosis | 1 1 |
Alveolar Epithelium, Hyperplasia | 1 1 4 3 3 1 4 1 1 2|
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Inflammation, Suppurative | 2 1 2 2 2 2 |
Thrombosis | 3 1 2 |
Goblet Cell, Respiratory Epithelium, | |
Hyperplasia | 2 |
Olfactory Epithelium, Atrophy | 2 1 1 |
Olfactory Epithelium, Metaplasia | 2 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + |
Cataract | 3 |
Cornea, Inflammation, Suppurative | |
Cornea, Mineralization | |
Retina, Atrophy | 4 |
|__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 3 |
Infarct | 2 3 2 |
Metaplasia, Osseous | |
Mineralization | 2 |
__________________________________________|__________________________________________________________________________|
Page 60
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7| 6| 7| 4| 7| 7| 7| 6| 6| 5| 7|
DAY ON TEST | 2| 2| 3| 0| 1| 3| 2| 8| 4| 3| 2| 2| 5| 2| 2| 9| 3| 5| 3| 2| 2| 4| 6| 6| 2|
| 9| 9| 0| 9| 7| 0| 9| 0| 9| 0| 9| 6| 0| 9| 9| 8| 0| 6| 0| 9| 9| 9| 1| 4| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.25% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
Nephropathy | 2 3 2 3 1 2 4 1 2 2 3 4 3 1 2 1 3 2 2 2 2 2 2|
Pigmentation | 3 3 |
Papilla, Necrosis | 2 |
Transitional Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
Inflammation, Chronic Active | 3 |
__________________________________________|__________________________________________________________________________
Page 61
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 7| 5| 5| 7| 6| 5| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 3| 5| 2| 2| 3| 0| 2| 2| 5| 8| 1| 8| 2| 3| 1| 3| 1| 2| 2| 1| 2| |
| 9| 9| 1| 9| 0| 8| 9| 9| 0| 5| 9| 9| 4| 6| 6| 4| 8| 0| 4| 0| 7| 9| 8| 1| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
0.25% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + A + + + + + + + + + + + +| 49 |
Parasite Metazoan | X | 1 |
Ulcer | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X | 3 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A + + + + + + + + + A + + + + + + + A + + + +| 46 |
Ulcer | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + A + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A + + + + + + + + + A + + + + + + + A + + + +| 45 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + + + + + + + + + A + A + + + + + A + A + +| 42 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X X X X X| 35 |
Clear Cell Focus | X X X X X X X X X X X X| 22 |
Degeneration, Cystic | 1 2 | 3 1.7|
Fatty Change | 3 2 2 | 5 2.2|
Hepatodiaphragmatic Nodule | | 5 |
Inflammation, Focal, Granulomatous | 1 1 1 1 1 1 1 1 2 2 1 1 1 1| 26 1.1|
Inflammation, Focal, Histiocytic | 2 1 1 2 1 1 1 1 1 2 2 1 1 1 2 2 1 | 27 1.3|
Mixed Cell Focus | X | 2 |
Vacuolization Cytoplasmic, Focal | | 1 2.0|
Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 1 2 2 2 1 2 1 2 3 2| 38 1.5|
Centrilobular, Necrosis | 3 1 2 1 | 11 1.7|
|__________________________________________________________________________|____________|
Mesentery | + + + + | 11 |
Fat, Necrosis | 3 3 3 | 9 2.4|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 7| 5| 5| 7| 6| 5| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 3| 5| 2| 2| 3| 0| 2| 2| 5| 8| 1| 8| 2| 3| 1| 3| 1| 2| 2| 1| 2| |
| 9| 9| 1| 9| 0| 8| 9| 9| 0| 5| 9| 9| 4| 6| 6| 4| 8| 0| 4| 0| 7| 9| 8| 1| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
0.25% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 3 1 1 1 2 2 1 2 2 1 2 4 2 3 | 20 2.0|
Basophilic Focus | X | 2 |
Hyperplasia | 2 2 | 6 2.5|
Thrombosis | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + M + +| 49 |
Atrophy | 2 2 2 | 5 2.0|
Basophilic Focus | | 1 |
Inflammation, Suppurative | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis | 2 | 1 2.0|
Hyperplasia, Squamous | 3 | 1 3.0|
Ulcer | 3 2 | 5 2.4|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + A + + + + + + + + + + + +| 49 |
Metaplasia | 4 | 1 4.0|
Mineralization | | 1 2.0|
Necrosis | 2 2 2 | 7 2.1|
|__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + | 1 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 3 2 2 1 2 1 2 2 2 2 2 2 1 1 3 2 3 1 1| 42 1.8|
Atrium, Thrombosis | 2 4 | 5 2.6|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 7| 5| 5| 7| 6| 5| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 3| 5| 2| 2| 3| 0| 2| 2| 5| 8| 1| 8| 2| 3| 1| 3| 1| 2| 2| 1| 2| |
| 9| 9| 1| 9| 0| 8| 9| 9| 0| 5| 9| 9| 4| 6| 6| 4| 8| 0| 4| 0| 7| 9| 8| 1| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
0.25% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Adrenal Cortex | + + + + + + + + + + + + A + + + + + + + + + + + +| 49 |
Hyperplasia | 2 2 2 3 2 2 2 1 2 2 2| 22 1.9|
Hypertrophy | 2 | 4 2.0|
Inflammation, Granulomatous | 1 | 1 1.0|
Necrosis | 2 3 3 | 4 2.5|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + A + + + + + + + + + + + +| 49 |
Hyperplasia | 2 2 4 4 3 2 2 2 3 | 23 2.4|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + A + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + M +| 48 |
Hyperplasia | | 4 2.5|
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + A + + + + + + + + + + + +| 49 |
Cyst | 1 1 1 | 4 1.0|
Pars Distalis, Hyperplasia | 3 2 2 1 2 | 16 2.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + A + + + + + + + + + A + +| 47 |
C-Cell, Hyperplasia | 2 3 2 2 2 2 1 1 2 1 1 1| 26 1.6|
Follicular Cell, Hyperplasia | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Peritoneum | + | 2 |
|__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + M M + + + + + + + +| 47 |
Hyperplasia | 2 | 3 1.7|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 64
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 7| 5| 5| 7| 6| 5| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 3| 5| 2| 2| 3| 0| 2| 2| 5| 8| 1| 8| 2| 3| 1| 3| 1| 2| 2| 1| 2| |
| 9| 9| 1| 9| 0| 8| 9| 9| 0| 5| 9| 9| 4| 6| 6| 4| 8| 0| 4| 0| 7| 9| 8| 1| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
0.25% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Inflammation, Chronic Active | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 3 2 3 | 11 2.5|
Inflammation, Chronic Active | 2 2 3 2 | 8 2.3|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + A + + + + + + + A + + + +| 48 |
Inflammation, Chronic Active | 3 | 2 3.0|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 3 4 | 4 3.3|
Interstitial Cell, Hyperplasia | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + A + + + + + + + A + + + +| 48 |
|__________________________________________________________________________|____________|
Lymph Node | + + + + + | 14 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M + + M + M + + M M M M M + M M + M M M M M M +| 16 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + A + + + M + + + + + + + +| 48 |
Inflammation, Granulomatous | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | | 5 2.2|
Hematopoietic Cell Proliferation | 2 2 3 | 5 2.6|
Hyperplasia, Focal, Lymphoid | 2 | 4 2.8|
Necrosis | 3 2 | 3 2.3|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + M + + + + + + + + +| 48 |
Atrophy | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 65
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 7| 5| 5| 7| 6| 5| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 3| 5| 2| 2| 3| 0| 2| 2| 5| 8| 1| 8| 2| 3| 1| 3| 1| 2| 2| 1| 2| |
| 9| 9| 1| 9| 0| 8| 9| 9| 0| 5| 9| 9| 4| 6| 6| 4| 8| 0| 4| 0| 7| 9| 8| 1| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
0.25% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + M + + M + + + M + M + M + + + M + + + M| 41 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Foreign Body | X | 1 |
Hyperkeratosis | 4 4 | 4 3.5|
Hyperplasia, Basal Cell | | 1 1.0|
Inflammation, Chronic Active | 2 | 1 2.0|
Prepuce, Inflammation, Suppurative | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + A + + + + + + + + + + + +| 49 |
Foreign Body | | 1 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 35 1.0|
Inflammation, Chronic Active | 1 | 2 1.5|
Metaplasia, Squamous | | 1 2.0|
Mineralization | | 1 2.0|
Thrombosis | | 2 1.0|
Alveolar Epithelium, Hyperplasia | 2 2 1 2 2 1 1 2| 18 1.9|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X X | 2 |
Inflammation, Suppurative | 1 2 3 3 2 1 2 2 2 1 1| 17 1.8|
Thrombosis | 4 2 | 5 2.4|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 66
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 7| 5| 5| 7| 6| 5| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 3| 5| 2| 2| 3| 0| 2| 2| 5| 8| 1| 8| 2| 3| 1| 3| 1| 2| 2| 1| 2| |
| 9| 9| 1| 9| 0| 8| 9| 9| 0| 5| 9| 9| 4| 6| 6| 4| 8| 0| 4| 0| 7| 9| 8| 1| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
0.25% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Goblet Cell, Respiratory Epithelium, | | |
Hyperplasia | | 1 2.0|
Olfactory Epithelium, Atrophy | | 3 1.3|
Olfactory Epithelium, Metaplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + A + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + | 2 |
Cataract | | 1 3.0|
Cornea, Inflammation, Suppurative | 3 | 1 3.0|
Cornea, Mineralization | 2 | 1 2.0|
Retina, Atrophy | | 1 4.0|
|__________________________________________________________________________|____________|
Zymbal's Gland | + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydronephrosis | | 1 3.0|
Infarct | 3 1 2 | 6 2.2|
Metaplasia, Osseous | 2 | 1 2.0|
Mineralization | 2 | 2 2.0|
Nephropathy | 3 2 3 3 3 3 2 3 2 1 4 2 1 1 2 2 2 2 2 2 3 2 2 2| 47 2.2|
Pigmentation | | 2 3.0|
Papilla, Necrosis | | 1 2.0|
Transitional Epithelium, Hyperplasia | 1 2 1 | 3 1.3|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 4.0|
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 67
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 5| 7| 6| 7| 6| 7| 3| 5| 7| 7| 7|
DAY ON TEST | 2| 6| 2| 9| 3| 3| 2| 3| 2| 3| 8| 2| 1| 8| 9| 3| 4| 2| 2| 2| 4| 8| 2| 2| 2|
| 6| 4| 9| 8| 0| 0| 5| 0| 7| 0| 4| 9| 2| 2| 8| 0| 7| 9| 7| 9| 0| 3| 9| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1.0% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + A + + + A + + + +|
Parasite Metazoan | X |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + A + + + +|
Parasite Metazoan | X X |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + A + + + A + + + +|
Inflammation, Acute | 2 |
Ulcer | 3 |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + A + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + A + + + A + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + A + + + A + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + A + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X |
Clear Cell Focus | X X X X X X X X X X |
Degeneration, Cystic | 2 1 |
Eosinophilic Focus | |
Fatty Change | 3 1 |
Hepatodiaphragmatic Nodule | X X |
Inflammation, Focal, Granulomatous | 1 2 1 2 3 2 1 2 1 1 2 1 1 2 1 2 1 1 2 1 2 |
Inflammation, Focal, Histiocytic | 2 1 2 2 1 2 2 2 2 2 2 2 1 2 2 2 1 1 2 1 2 2|
Mixed Cell Focus | X |
Thrombosis | 2 |
Bile Duct, Hyperplasia | 3 1 2 2 2 1 1 1 1 2 1 1 2 1 2 1 1 1 1 1 2 3|
Centrilobular, Necrosis | 1 1 1 3 2 1|
|__________________________________________________________________________|
Mesentery | + + + + + |
Fat, Necrosis | 2 2 3 3 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 3 3 2 1 2|
__________________________________________|__________________________________________________________________________|
Page 68
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 5| 7| 6| 7| 6| 7| 3| 5| 7| 7| 7|
DAY ON TEST | 2| 6| 2| 9| 3| 3| 2| 3| 2| 3| 8| 2| 1| 8| 9| 3| 4| 2| 2| 2| 4| 8| 2| 2| 2|
| 6| 4| 9| 8| 0| 0| 5| 0| 7| 0| 4| 9| 2| 2| 8| 0| 7| 9| 7| 9| 0| 3| 9| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1.0% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Basophilic Focus | |
Hyperplasia | 3 2|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Basal Cell | 1 |
Hyperplasia, Diffuse, Squamous | |
Hyperplasia, Squamous | 3 |
Inflammation, Chronic | |
Ulcer | 3 3 2 3 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 2 2 |
|__________________________________________________________________________|
Tongue | + |
|__________________________________________________________________________|
Tooth | +|
Inflammation, Chronic Active | 2|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 2 2 2 2 1 1 2 2 2 1 2 2 2 2 1 2 3 2 3 |
Necrosis | |
Atrium, Thrombosis | 4 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 2 1 2 2 1 2 2 1 2 2 2 |
Hypertrophy | 2 2 2|
Necrosis | |
Vacuolization Cytoplasmic | |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 2 2 4 2 4 3 2 4 4 2 3 4 2 3|
__________________________________________|__________________________________________________________________________|
Page 69
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 5| 7| 6| 7| 6| 7| 3| 5| 7| 7| 7|
DAY ON TEST | 2| 6| 2| 9| 3| 3| 2| 3| 2| 3| 8| 2| 1| 8| 9| 3| 4| 2| 2| 2| 4| 8| 2| 2| 2|
| 6| 4| 9| 8| 0| 0| 5| 0| 7| 0| 4| 9| 2| 2| 8| 0| 7| 9| 7| 9| 0| 3| 9| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1.0% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Pars Distalis, Hyperplasia | 2 2 1 2 2 2 2 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + A + + + +|
C-Cell, Hyperplasia | 3 2 1 2 1 1 1 1 2 1 2 1 2 1 2 1 1 |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Peritoneum | + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 1 2|
Inflammation, Chronic Active | 3 1 2 1 3 2 2 |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + A + + + +|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Interstitial Cell, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 70
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 5| 7| 6| 7| 6| 7| 3| 5| 7| 7| 7|
DAY ON TEST | 2| 6| 2| 9| 3| 3| 2| 3| 2| 3| 8| 2| 1| 8| 9| 3| 4| 2| 2| 2| 4| 8| 2| 2| 2|
| 6| 4| 9| 8| 0| 0| 5| 0| 7| 0| 4| 9| 2| 2| 8| 0| 7| 9| 7| 9| 0| 3| 9| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1.0% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Granulomatous | 1 |
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + +|
Bronchial, Ectasia | 3 |
Mediastinal, Ectasia | 4 |
Mediastinal, Hyperplasia | 2 |
Mediastinal, Infiltration Cellular, | |
Plasma Cell | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + M M M M M + M M M M M M + M M M M M M M M M M +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + A + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + A + + + +|
Fibrosis | 2 2 3|
Hematopoietic Cell Proliferation | 2 2 |
Hyperplasia, Focal, Lymphoid | 2 3 4 3 |
Necrosis | 3 |
|__________________________________________________________________________|
Thymus | + + + + + + + M M + + + + M + M + + + + A + + + +|
Atrophy | 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + M + + + + + + + + + M + + + + + +|
Galactocele | 2 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | |
Cyst, Squamous | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 71
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 5| 7| 6| 7| 6| 7| 3| 5| 7| 7| 7|
DAY ON TEST | 2| 6| 2| 9| 3| 3| 2| 3| 2| 3| 8| 2| 1| 8| 9| 3| 4| 2| 2| 2| 4| 8| 2| 2| 2|
| 6| 4| 9| 8| 0| 0| 5| 0| 7| 0| 4| 9| 2| 2| 8| 0| 7| 9| 7| 9| 0| 3| 9| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1.0% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM - cont | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Gliosis | |
Necrosis | 2 |
|__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 1 1 4 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Inflammation, Chronic Active | 1 1 2 |
Inflammation, Suppurative | |
Metaplasia, Squamous | 1 2 2 |
Thrombosis | 1 |
Alveolar Epithelium, Hyperplasia | 3 4 1 1 3 2 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 1 2 2 2 1 1 1 |
Thrombosis | 3 1 |
Olfactory Epithelium, Atrophy | 1 1 |
|__________________________________________________________________________|
Pleura | |
Inflammation, Chronic | |
Inflammation, Suppurative | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + A + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + |
Cataract | 4 |
Degeneration | 3 |
Retina, Atrophy | 4 |
|__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 72
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 5| 7| 6| 7| 6| 7| 3| 5| 7| 7| 7|
DAY ON TEST | 2| 6| 2| 9| 3| 3| 2| 3| 2| 3| 8| 2| 1| 8| 9| 3| 4| 2| 2| 2| 4| 8| 2| 2| 2|
| 6| 4| 9| 8| 0| 0| 5| 0| 7| 0| 4| 9| 2| 2| 8| 0| 7| 9| 7| 9| 0| 3| 9| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1.0% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 3 |
Infarct | 2 |
Mineralization | 2 |
Nephropathy | 4 2 3 3 3 2 4 3 2 3 2 2 2 3 4 3 2 2 2 3 2 2 4 4 3|
Pigmentation | 3 |
Renal Tubule, Accumulation, Hyaline | |
Droplet | 4 |
Transitional Epithelium, Hyperplasia | 2 2 1 1 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + A + + + +|
Inflammation, Suppurative | 3 |
__________________________________________|__________________________________________________________________________
Page 73
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 6| 7| 6| 7| |
DAY ON TEST | 4| 2| 2| 1| 8| 1| 2| 3| 2| 2| 3| 2| 3| 1| 2| 7| 2| 6| 2| 2| 3| 4| 3| 4| 3| |
| 3| 3| 9| 7| 6| 9| 9| 0| 9| 9| 0| 9| 0| 8| 9| 4| 9| 2| 9| 9| 0| 9| 0| 9| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
1.0% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Parasite Metazoan | X X | 3 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + A + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Parasite Metazoan | X X X X| 6 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Inflammation, Acute | | 1 2.0|
Ulcer | | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + A + + + + + + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Basophilic Focus | X X X X X X X X X X X| 26 |
Clear Cell Focus | X X X X X X X X X X X X X| 23 |
Degeneration, Cystic | 2 1 2 2 | 6 1.7|
Eosinophilic Focus | X X | 2 |
Fatty Change | 4 | 3 2.7|
Hepatodiaphragmatic Nodule | X X | 4 |
Inflammation, Focal, Granulomatous | 2 1 2 2 2 1 2 2 1 1 2 1 2 1 1 2 1 1 2 1 1| 42 1.5|
Inflammation, Focal, Histiocytic | 2 2 1 1 1 1 2 2 2 2 2 2 2 2 2 1 2 2 1 1 2 2 2 1| 46 1.7|
Mixed Cell Focus | X | 2 |
Thrombosis | | 1 2.0|
Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 2 2 1 1 1 2 1 1 1 1 3 1 2 2| 43 1.4|
Centrilobular, Necrosis | 1 1 3 2 3 3 | 12 1.8|
|__________________________________________________________________________|____________|
Mesentery | + | 6 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 74
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 6| 7| 6| 7| |
DAY ON TEST | 4| 2| 2| 1| 8| 1| 2| 3| 2| 2| 3| 2| 3| 1| 2| 7| 2| 6| 2| 2| 3| 4| 3| 4| 3| |
| 3| 3| 9| 7| 6| 9| 9| 0| 9| 9| 0| 9| 0| 8| 9| 4| 9| 2| 9| 9| 0| 9| 0| 9| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
1.0% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Fat, Necrosis | 2 | 5 2.4|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 2 1 2 2 | 12 1.9|
Basophilic Focus | X X | 2 |
Hyperplasia | 3 2 | 4 2.5|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | | 1 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Basal Cell | | 1 1.0|
Hyperplasia, Diffuse, Squamous | 2 | 1 2.0|
Hyperplasia, Squamous | 1 2 | 3 2.0|
Inflammation, Chronic | 2 | 1 2.0|
Ulcer | 3 4 2 1 | 8 2.6|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | | 2 2.0|
|__________________________________________________________________________|____________|
Tongue | | 1 |
|__________________________________________________________________________|____________|
Tooth | + + | 3 |
Inflammation, Chronic Active | 2 1 | 3 1.7|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 2 2 1 2 2 2 2 2 2 2 2 2 1 2 2 1 3 2 2 2| 43 1.9|
Necrosis | 2 | 1 2.0|
Atrium, Thrombosis | | 2 3.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 75
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 6| 7| 6| 7| |
DAY ON TEST | 4| 2| 2| 1| 8| 1| 2| 3| 2| 2| 3| 2| 3| 1| 2| 7| 2| 6| 2| 2| 3| 4| 3| 4| 3| |
| 3| 3| 9| 7| 6| 9| 9| 0| 9| 9| 0| 9| 0| 8| 9| 4| 9| 2| 9| 9| 0| 9| 0| 9| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
1.0% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 1 2 1 2 2 2 1 2 2 2 2 1 | 26 1.7|
Hypertrophy | 2 2 2 | 6 2.0|
Necrosis | 2 | 1 2.0|
Vacuolization Cytoplasmic | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 4 2 3 2 3 2 3 1 | 24 2.8|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 4 | 2 2.5|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + + + + + +| 49 |
Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 1 | 1 1.0|
Pars Distalis, Hyperplasia | 1 3 1 2 2 2 1 2 1 | 16 1.8|
|__________________________________________________________________________|____________|
Thyroid Gland | + A + + + + + + + + + + + + + + + + + + + + + + +| 48 |
C-Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 2 1 | 31 1.3|
Follicular Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Peritoneum | | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 4 | 3 3.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 76
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 6| 7| 6| 7| |
DAY ON TEST | 4| 2| 2| 1| 8| 1| 2| 3| 2| 2| 3| 2| 3| 1| 2| 7| 2| 6| 2| 2| 3| 4| 3| 4| 3| |
| 3| 3| 9| 7| 6| 9| 9| 0| 9| 9| 0| 9| 0| 8| 9| 4| 9| 2| 9| 9| 0| 9| 0| 9| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
1.0% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 1 2 3 | 10 2.0|
Inflammation, Chronic Active | 2 2 2 3 2| 12 2.1|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 3.0|
Interstitial Cell, Hyperplasia | | 2 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Granulomatous | | 1 1.0|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + +| 21 |
Bronchial, Ectasia | | 1 3.0|
Mediastinal, Ectasia | | 1 4.0|
Mediastinal, Hyperplasia | | 1 2.0|
Mediastinal, Infiltration Cellular, | | |
Plasma Cell | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M M + + M + + M M M M M + M + + M + M + M M +| 14 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Fibrosis | 2 | 4 2.3|
Hematopoietic Cell Proliferation | | 2 2.0|
Hyperplasia, Focal, Lymphoid | 3 3 3 2 2 | 9 2.8|
Necrosis | 3 | 2 3.0|
|__________________________________________________________________________|____________|
Thymus | + + + + M + + + + + + + + + + M + + + + + + + + +| 43 |
Atrophy | | 1 4.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 77
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 6| 7| 6| 7| |
DAY ON TEST | 4| 2| 2| 1| 8| 1| 2| 3| 2| 2| 3| 2| 3| 1| 2| 7| 2| 6| 2| 2| 3| 4| 3| 4| 3| |
| 3| 3| 9| 7| 6| 9| 9| 0| 9| 9| 0| 9| 0| 8| 9| 4| 9| 2| 9| 9| 0| 9| 0| 9| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
1.0% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + M + + + + + + + + + + + + + + + + + + + + + +| 47 |
Galactocele | | 1 2.0|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + I + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
Cyst, Squamous | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Gliosis | 2 | 1 2.0|
Necrosis | | 1 2.0|
|__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 39 1.1|
Inflammation, Chronic Active | 1 | 4 1.3|
Inflammation, Suppurative | 2 | 1 2.0|
Metaplasia, Squamous | | 3 1.7|
Thrombosis | | 1 1.0|
Alveolar Epithelium, Hyperplasia | 1 3 1 1| 10 2.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 2 1 2 1 2 1 2 | 15 1.5|
Thrombosis | 3 1 | 4 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 78
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 6| 7| 6| 7| |
DAY ON TEST | 4| 2| 2| 1| 8| 1| 2| 3| 2| 2| 3| 2| 3| 1| 2| 7| 2| 6| 2| 2| 3| 4| 3| 4| 3| |
| 3| 3| 9| 7| 6| 9| 9| 0| 9| 9| 0| 9| 0| 8| 9| 4| 9| 2| 9| 9| 0| 9| 0| 9| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
1.0% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Olfactory Epithelium, Atrophy | 1 | 3 1.0|
|__________________________________________________________________________|____________|
Pleura | + + | 2 |
Inflammation, Chronic | 3 | 1 3.0|
Inflammation, Suppurative | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + | 3 |
Cataract | 4 | 2 4.0|
Degeneration | | 1 3.0|
Retina, Atrophy | 4 | 2 4.0|
|__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 | 3 2.7|
Infarct | 2 2 | 3 2.0|
Mineralization | | 1 2.0|
Nephropathy | 2 4 4 3 2 1 3 4 3 2 4 4 3 2 3 3 4 2 3 2 2 2 2 3 3| 50 2.8|
Pigmentation | | 1 3.0|
Renal Tubule, Accumulation, Hyaline | | |
Droplet | 1 | 2 2.5|
Transitional Epithelium, Hyperplasia | 1 1 1 | 7 1.3|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 79
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
_____________________________________________________________________________________________________________________
| 4| 5| 5| 6| 6| 6| 6| 6| 5| 5| 6| 5| 6| 6| 6| 5| 5| 4| 6| 5| 5| 6| 6| 4| 6|
DAY ON TEST | 8| 9| 8| 4| 1| 1| 1| 2| 9| 6| 1| 2| 1| 1| 9| 9| 0| 8| 1| 3| 6| 8| 4| 4| 5|
| 4| 8| 6| 5| 9| 4| 0| 9| 6| 4| 3| 5| 4| 0| 0| 8| 2| 4| 3| 2| 4| 2| 0| 9| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
4.0% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | A + + + + + + + A + + + + + + + + + + A + + A + +|
Ulcer | |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + A + + + + + + + + + + A + + A + +|
|__________________________________________________________________________|
Intestine Large, Cecum | A + + + A + A + A + + A + + + + + A + A A + A + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + M + A + + A + + + + + M + A + + A + +|
Necrosis | 2 |
|__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + A + A + + A + + + + + M + A + + A + +|
|__________________________________________________________________________|
Intestine Small, Ileum | A + + + A + A + A + + A + + + + + A + A A + A + +|
Necrosis | 2 |
|__________________________________________________________________________|
Liver | + + + + + + M + + + + + + + + + + + + A + + + + +|
Angiectasis | 1 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X |
Clear Cell Focus | |
Degeneration, Cystic | |
Fatty Change | 2 1 |
Hepatodiaphragmatic Nodule | X X X |
Inflammation, Focal, Granulomatous | 1 1 1 1 1 1 1 |
Inflammation, Focal, Histiocytic | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2|
Mixed Cell Focus | |
Bile Duct, Hyperplasia | 2 1 1 1 2 1 2 2 1 2 1 1 1 1 1 1 1 2 1 3 1 2|
Centrilobular, Necrosis | 2 2|
|__________________________________________________________________________|
Mesentery | + + +|
Fat, Necrosis | 2 2 2|
|__________________________________________________________________________|
Oral Mucosa | + + |
Pharyngeal, Hyperplasia | 4 |
|__________________________________________________________________________|
Pancreas | + + + + + + M + M + + + + + + + + + + A + + + + +|
__________________________________________|__________________________________________________________________________|
Page 80
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
_____________________________________________________________________________________________________________________
| 4| 5| 5| 6| 6| 6| 6| 6| 5| 5| 6| 5| 6| 6| 6| 5| 5| 4| 6| 5| 5| 6| 6| 4| 6|
DAY ON TEST | 8| 9| 8| 4| 1| 1| 1| 2| 9| 6| 1| 2| 1| 1| 9| 9| 0| 8| 1| 3| 6| 8| 4| 4| 5|
| 4| 8| 6| 5| 9| 4| 0| 9| 6| 4| 3| 5| 4| 0| 0| 8| 2| 4| 3| 2| 4| 2| 0| 9| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
4.0% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Atrophy | 1 2 1 1 |
Hyperplasia | 2 2|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 1 2 1 3 3 2 3 1 1 |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + A + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia, Basal Cell | 1 |
Hyperplasia, Diffuse, Squamous | |
Hyperplasia, Squamous | 2 2 |
Inflammation, Suppurative | 2 |
Ulcer | 2 2 3 3 3 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + A + + + + + + + + + + A + + + + +|
Cyst, Squamous | 3 |
Mineralization | |
Necrosis | 1 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | |
Aorta, Mineralization | |
|__________________________________________________________________________|
Heart | + + + + + + M + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 1 1 1 1 1 2 3|
Mineralization | 1 1 |
Valve, Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + M + + + + + + + + + + A + + + + + + +|
Hyperplasia | 1 1 2 3|
Hypertrophy | 1 2 1|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + M + + + + + + + + + + A + A + + + + +|
Hyperplasia | 2 2 2 |
Necrosis | |
__________________________________________|__________________________________________________________________________|
Page 81
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
_____________________________________________________________________________________________________________________
| 4| 5| 5| 6| 6| 6| 6| 6| 5| 5| 6| 5| 6| 6| 6| 5| 5| 4| 6| 5| 5| 6| 6| 4| 6|
DAY ON TEST | 8| 9| 8| 4| 1| 1| 1| 2| 9| 6| 1| 2| 1| 1| 9| 9| 0| 8| 1| 3| 6| 8| 4| 4| 5|
| 4| 8| 6| 5| 9| 4| 0| 9| 6| 4| 3| 5| 4| 0| 0| 8| 2| 4| 3| 2| 4| 2| 0| 9| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
4.0% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + M + M + + + + + + + + + + A + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 1|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + A + + + + +|
Angiectasis | 2 |
Pars Distalis, Hyperplasia | 1 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + A + A + + A + +|
C-Cell, Hyperplasia | 2 2 1 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + A + + + + +|
Granuloma Sperm | 2 |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3|
Hyperplasia | 2 |
Inflammation, Chronic Active | 2 |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 3 |
|__________________________________________________________________________|
Seminal Vesicle | A + + + + + M + + + + A + + + + + + + A + + + + +|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 3 |
Interstitial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 82
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
_____________________________________________________________________________________________________________________
| 4| 5| 5| 6| 6| 6| 6| 6| 5| 5| 6| 5| 6| 6| 6| 5| 5| 4| 6| 5| 5| 6| 6| 4| 6|
DAY ON TEST | 8| 9| 8| 4| 1| 1| 1| 2| 9| 6| 1| 2| 1| 1| 9| 9| 0| 8| 1| 3| 6| 8| 4| 4| 5|
| 4| 8| 6| 5| 9| 4| 0| 9| 6| 4| 3| 5| 4| 0| 0| 8| 2| 4| 3| 2| 4| 2| 0| 9| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
4.0% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + A + + + + + + + A + + + + +|
|__________________________________________________________________________|
Lymph Node | + + + + +|
Mediastinal, Ectasia | 2 |
Mediastinal, Hemorrhage | |
Mediastinal, Inflammation, | |
Granulomatous | |
|__________________________________________________________________________|
Lymph Node, Mandibular | M M M M M M + M M + M M M M M M + M + M M M + M M|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + A + + + + + + + + + + A + + A + +|
|__________________________________________________________________________|
Spleen | + + + + + + M + M + + + + + + + + + + A + + + + +|
Fibrosis | 2 3 |
Hyperplasia, Focal, Lymphoid | 2 2|
|__________________________________________________________________________|
Thymus | + M + + M + M + + + + + + + M + + + + + M + + + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + M + + + + + + M + M + + + + + + +|
|__________________________________________________________________________|
Skin | + + I + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Hemorrhage | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + |
Mineralization | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________|__________________________________________________________________________|
Page 83
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
_____________________________________________________________________________________________________________________
| 4| 5| 5| 6| 6| 6| 6| 6| 5| 5| 6| 5| 6| 6| 6| 5| 5| 4| 6| 5| 5| 6| 6| 4| 6|
DAY ON TEST | 8| 9| 8| 4| 1| 1| 1| 2| 9| 6| 1| 2| 1| 1| 9| 9| 0| 8| 1| 3| 6| 8| 4| 4| 5|
| 4| 8| 6| 5| 9| 4| 0| 9| 6| 4| 3| 5| 4| 0| 0| 8| 2| 4| 3| 2| 4| 2| 0| 9| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
4.0% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM - cont | |
|__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + A + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Inflammation, Chronic Active | 1 |
Mineralization | |
Thrombosis | 2 |
Alveolar Epithelium, Hyperplasia | 1 1 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + A + + + + +|
Inflammation, Suppurative | 1 2 3 1|
Thrombosis | 3 3 3 4 |
Olfactory Epithelium, Atrophy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Olfactory Epithelium, Degeneration | 3 3 3|
Olfactory Epithelium, Metaplasia | |
Respiratory Epithelium, Hyperplasia | 1 |
|__________________________________________________________________________|
Trachea | + + + + + + + + A + + A + + + + + + + A + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | |
Cataract | |
Retina, Atrophy | |
|__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + M + + + + + + + + + + + + A + + + + +|
Hydronephrosis | |
Infarct | 2 2|
Mineralization | |
Nephropathy | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 3 4 3|
Transitional Epithelium, Hyperplasia | 1 1 1 1 1 |
__________________________________________|__________________________________________________________________________|
Page 84
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
_____________________________________________________________________________________________________________________
| 4| 5| 5| 6| 6| 6| 6| 6| 5| 5| 6| 5| 6| 6| 6| 5| 5| 4| 6| 5| 5| 6| 6| 4| 6|
DAY ON TEST | 8| 9| 8| 4| 1| 1| 1| 2| 9| 6| 1| 2| 1| 1| 9| 9| 0| 8| 1| 3| 6| 8| 4| 4| 5|
| 4| 8| 6| 5| 9| 4| 0| 9| 6| 4| 3| 5| 4| 0| 0| 8| 2| 4| 3| 2| 4| 2| 0| 9| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
4.0% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + A + + + + +|
Mineralization | |
Necrosis | |
__________________________________________|__________________________________________________________________________
Page 85
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
__________________________________________________________________________________________________________________________________
| 5| 6| 5| 5| 4| 6| 4| 6| 5| 5| 6| 3| 5| 5| 5| 6| 6| 6| 6| 4| 5| 5| 4| 5| 4| |
DAY ON TEST | 2| 2| 6| 8| 3| 2| 3| 3| 6| 7| 4| 9| 5| 4| 0| 2| 1| 2| 7| 8| 7| 8| 0| 6| 8| |
| 9| 7| 5| 9| 1| 7| 8| 1| 4| 8| 7| 8| 4| 3| 7| 7| 7| 4| 3| 4| 4| 4| 8| 1| 3| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
4.0% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + A + A + + + + + + + + + A + + + + +| 43 |
Ulcer | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + A + A + + + + + + + + + + + + I + +| 44 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + A + A + A A + + + + + + A + + + + A| 35 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + A + + + + + + + + + + + + +| 42 |
Necrosis | | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + A + A + A + + + + + + + + + + + + A| 39 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + A + A + A A + + + + + + + + + + + A| 36 |
Necrosis | | 1 2.0|
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Angiectasis | 2 | 2 1.5|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X X X| 45 |
Clear Cell Focus | X X | 2 |
Degeneration, Cystic | 2 2 | 2 2.0|
Fatty Change | 2 2 1| 5 1.6|
Hepatodiaphragmatic Nodule | X X | 5 |
Inflammation, Focal, Granulomatous | 2 2 2 1 2 1 2 2 2 2 3 1 1 1 1 1 1 1 1 1| 27 1.4|
Inflammation, Focal, Histiocytic | 3 3 3 3 2 3 2 3 3 3 3 3 3 3 3 2 3 2 2 3 3 3 3 3 3| 48 2.9|
Mixed Cell Focus | X X | 2 |
Bile Duct, Hyperplasia | 2 1 1 1 2 1 1 1 1 1 1 1 1 1 2 1 1 2 1 3 2 1| 44 1.4|
Centrilobular, Necrosis | 4 | 3 2.7|
|__________________________________________________________________________|____________|
Mesentery | + | 4 |
Fat, Necrosis | 3 | 4 2.3|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 86
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
__________________________________________________________________________________________________________________________________
| 5| 6| 5| 5| 4| 6| 4| 6| 5| 5| 6| 3| 5| 5| 5| 6| 6| 6| 6| 4| 5| 5| 4| 5| 4| |
DAY ON TEST | 2| 2| 6| 8| 3| 2| 3| 3| 6| 7| 4| 9| 5| 4| 0| 2| 1| 2| 7| 8| 7| 8| 0| 6| 8| |
| 9| 7| 5| 9| 1| 7| 8| 1| 4| 8| 7| 8| 4| 3| 7| 7| 7| 4| 3| 4| 4| 4| 8| 1| 3| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
4.0% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Oral Mucosa | | 2 |
Pharyngeal, Hyperplasia | | 1 4.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Atrophy | 2 2 2 1 1 | 9 1.4|
Hyperplasia | 2 2 2 | 5 2.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 2 1 2 2 1 1 1 2 2 1 3 | 22 1.8|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 1 | 1 1.0|
Hyperplasia, Basal Cell | 2 | 2 1.5|
Hyperplasia, Diffuse, Squamous | 1 | 1 1.0|
Hyperplasia, Squamous | 1 1 1 | 5 1.4|
Inflammation, Suppurative | | 1 2.0|
Ulcer | 2 4 1 2 2 | 10 2.4|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Cyst, Squamous | | 1 3.0|
Mineralization | 2 3 | 2 2.5|
Necrosis | 2 1 3 | 5 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + | 2 |
Aorta, Mineralization | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cardiomyopathy | 1 1 2 1 2 2 2 2 1 2 1 1 1 | 22 1.5|
Mineralization | 1 2 2 1 1| 7 1.3|
Valve, Inflammation, Acute | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 87
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
__________________________________________________________________________________________________________________________________
| 5| 6| 5| 5| 4| 6| 4| 6| 5| 5| 6| 3| 5| 5| 5| 6| 6| 6| 6| 4| 5| 5| 4| 5| 4| |
DAY ON TEST | 2| 2| 6| 8| 3| 2| 3| 3| 6| 7| 4| 9| 5| 4| 0| 2| 1| 2| 7| 8| 7| 8| 0| 6| 8| |
| 9| 7| 5| 9| 1| 7| 8| 1| 4| 8| 7| 8| 4| 3| 7| 7| 7| 4| 3| 4| 4| 4| 8| 1| 3| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
4.0% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 2 1 1 3| 8 1.8|
Hypertrophy | 2 2 | 5 1.6|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Hyperplasia | 1 | 4 1.8|
Necrosis | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 1 | 5 1.2|
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | | 1 2.0|
Pars Distalis, Hyperplasia | 1 3 2 2 1 | 6 1.7|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
C-Cell, Hyperplasia | | 3 1.7|
Follicular Cell, Hyperplasia | 1 3 | 2 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Granuloma Sperm | | 1 2.0|
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 2 3.0|
Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 88
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
__________________________________________________________________________________________________________________________________
| 5| 6| 5| 5| 4| 6| 4| 6| 5| 5| 6| 3| 5| 5| 5| 6| 6| 6| 6| 4| 5| 5| 4| 5| 4| |
DAY ON TEST | 2| 2| 6| 8| 3| 2| 3| 3| 6| 7| 4| 9| 5| 4| 0| 2| 1| 2| 7| 8| 7| 8| 0| 6| 8| |
| 9| 7| 5| 9| 1| 7| 8| 1| 4| 8| 7| 8| 4| 3| 7| 7| 7| 4| 3| 4| 4| 4| 8| 1| 3| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
4.0% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Inflammation, Chronic Active | | 1 2.0|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 1 1 | 5 1.6|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 | 3 2.3|
Interstitial Cell, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Lymph Node | + + + + | 9 |
Mediastinal, Ectasia | 4 | 2 3.0|
Mediastinal, Hemorrhage | 1 | 1 1.0|
Mediastinal, Inflammation, | | |
Granulomatous | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + M M + M M M M + M M M M M M M + M M + + M M M| 11 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Fibrosis | | 2 2.5|
Hyperplasia, Focal, Lymphoid | | 2 2.0|
|__________________________________________________________________________|____________|
Thymus | + + M M + + + + + + + + + + + M + + + + + + + + +| 41 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + M + + + + + + + M + + + + + M + +| 44 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 89
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
__________________________________________________________________________________________________________________________________
| 5| 6| 5| 5| 4| 6| 4| 6| 5| 5| 6| 3| 5| 5| 5| 6| 6| 6| 6| 4| 5| 5| 4| 5| 4| |
DAY ON TEST | 2| 2| 6| 8| 3| 2| 3| 3| 6| 7| 4| 9| 5| 4| 0| 2| 1| 2| 7| 8| 7| 8| 0| 6| 8| |
| 9| 7| 5| 9| 1| 7| 8| 1| 4| 8| 7| 8| 4| 3| 7| 7| 7| 4| 3| 4| 4| 4| 8| 1| 3| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
4.0% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Subcutaneous Tissue, Hemorrhage | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
Mineralization | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
|__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 34 1.0|
Inflammation, Chronic Active | | 1 1.0|
Mineralization | 3 | 1 3.0|
Thrombosis | 1 2 | 3 1.7|
Alveolar Epithelium, Hyperplasia | 2 3 1 | 5 1.6|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 1 2 | 6 1.7|
Thrombosis | 2 2 2 3 4| 9 2.9|
Olfactory Epithelium, Atrophy | 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 | 34 1.0|
Olfactory Epithelium, Degeneration | 1 3 2 2 | 7 2.4|
Olfactory Epithelium, Metaplasia | 2 2 | 2 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 90
NTP Experiment-Test: 88031-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 02/04/02
Route: DOSED WATER Time: 10:30:16
__________________________________________________________________________________________________________________________________
| 5| 6| 5| 5| 4| 6| 4| 6| 5| 5| 6| 3| 5| 5| 5| 6| 6| 6| 6| 4| 5| 5| 4| 5| 4| |
DAY ON TEST | 2| 2| 6| 8| 3| 2| 3| 3| 6| 7| 4| 9| 5| 4| 0| 2| 1| 2| 7| 8| 7| 8| 0| 6| 8| |
| 9| 7| 5| 9| 1| 7| 8| 1| 4| 8| 7| 8| 4| 3| 7| 7| 7| 4| 3| 4| 4| 4| 8| 1| 3| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
4.0% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Respiratory Epithelium, Hyperplasia | | 1 1.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + | 1 |
Cataract | 2 | 1 2.0|
Retina, Atrophy | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hydronephrosis | 2 | 1 2.0|
Infarct | | 2 2.0|
Mineralization | 3 3 | 2 3.0|
Nephropathy | 4 4 4 4 4 4 2 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 3 4 4| 48 3.9|
Transitional Epithelium, Hyperplasia | 1 1 1 1 | 9 1.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Mineralization | 3 | 1 3.0|
Necrosis | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
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