TDMS Study 88031-06 Pathology Tables
NTP FEED, WATER, AND COMPOUND CONSUMPTION TABLE REPORT: EISRPT39
LAB: Battelle Columbus DIPROPYLENE GLYCOL DATE: 06/18/01
EXPERIMENT: 88031 TEST: 06 TIME: 14:01:07
CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: DOSED WATER NTP: C88031
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP FEED, WATER, AND COMPOUND CONSUMPTION TABLE REPORT: EISRPT39
LAB: BATTELLE COLUMBUS DIPROPYLENE GLYCOL DATE: 06/18/01
EXPERIMENT: 88031 TEST: 06 TIME: 14:16:38
TEST TYPE: CHRONIC ROUTE: DOSED WATER NTP: C88031
CONT: N01-ES-55388 CAS: 25265-71-8
WATER AND COMPOUND CONSUMPTION BY MALE MICE IN THE
CHRONIC DOSED WATER STUDY OF DIPROPYLENE GLYCOL
==================================================================================================================================
0.0% 1.0% 2.0% 4.0%
---------------- --------------------------------- --------------------------------- ---------------------------------
DOSE/ DOSE/ DOSE/
GRAMS BODY GRAMS BODY CONTROL GRAMS BODY CONTROL GRAMS BODY CONTROL
WATER/ WEIGHT WATER/ WEIGHT WATER (B) DOSE/ WATER/ WEIGHT WATER (B) DOSE/ WATER/ WEIGHT WATER (B) DOSE/
WEEK DAY(A) (GRAMS) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C)
==================================================================================================================================
2 3.4 23.7 3.4 24.1 1.00 1423 1.9 22.1 0.56 1743 1.1 18.2 0.32 2322
6 3.2 29.7 3.0 29.9 0.94 995 2.3 28.5 0.72 1638 2.0 25.6 0.63 3088
10 2.9 35.8 2.7 35.9 0.93 749 2.3 34.2 0.79 1344 1.9 30.5 0.66 2495
14 2.9 40.4 2.8 40.6 0.97 690 2.6 38.5 0.90 1342 2.2 34.3 0.76 2604
18 3.0 44.6 2.9 45.0 0.97 655 2.5 42.5 0.83 1175 2.3 37.9 0.77 2472
22 3.1 46.7 2.9 46.6 0.94 631 2.6 45.0 0.84 1162 2.5 41.0 0.81 2446
26 3.4 48.1 3.3 48.1 0.97 676 2.9 46.7 0.85 1230 2.5 42.0 0.74 2415
30 3.3 49.3 3.0 48.7 0.91 611 2.7 48.2 0.82 1110 2.4 43.5 0.73 2245
34 3.7 50.2 3.4 49.9 0.92 686 3.0 48.9 0.81 1227 2.5 43.5 0.68 2298
38 3.7 51.3 3.3 50.9 0.89 643 2.9 50.2 0.78 1139 2.4 44.3 0.65 2137
42 3.8 51.6 3.3 51.2 0.87 652 2.9 50.6 0.76 1127 2.3 43.9 0.61 2071
46 4.0 52.5 3.5 52.1 0.88 665 3.0 51.4 0.75 1160 2.5 44.0 0.63 2244
50 4.0 52.8 3.5 52.4 0.88 666 2.8 51.9 0.70 1089 2.3 44.6 0.58 2033
54 4.3 53.1 3.6 52.5 0.84 686 3.1 52.1 0.72 1188 2.6 45.7 0.60 2307
58 4.3 53.1 3.7 52.8 0.86 701 3.0 51.8 0.70 1155 2.6 45.6 0.60 2318
62 4.4 53.9 3.7 53.8 0.84 680 2.9 52.4 0.66 1122 2.7 47.3 0.61 2306
66 4.4 53.9 4.1 53.8 0.93 753 3.2 52.5 0.73 1208 3.0 48.1 0.68 2529
70 4.2 53.5 3.8 53.6 0.90 702 3.0 52.0 0.71 1150 3.0 47.8 0.71 2501
74 4.3 52.4 3.7 53.6 0.86 693 2.8 51.6 0.65 1099 3.0 46.6 0.70 2595
78 4.4 52.5 3.9 53.0 0.89 739 3.0 51.6 0.68 1149 2.9 47.2 0.66 2424
82 4.5 53.1 3.7 53.4 0.82 699 3.0 52.4 0.67 1142 3.0 46.2 0.67 2578
86 4.5 53.2 3.8 52.5 0.84 730 3.0 50.4 0.67 1180 2.4 43.4 0.53 2256
90 4.5 52.6 3.7 52.0 0.82 706 2.8 49.3 0.62 1156 2.0 41.4 0.44 1947
94 4.2 51.5 3.9 51.1 0.93 757 3.1 48.7 0.74 1254 2.6 40.0 0.62 2602
98 4.1 50.3 3.6 50.4 0.88 705 2.9 49.8 0.71 1161 2.5 39.6 0.61 2479
102 4.3 48.6 3.6 49.1 0.84 729 3.1 48.4 0.72 1293 2.3 37.3 0.53 2464
1 TO 13 WEEKS
----------------
MEAN 3.2 29.7 3.0 30.0 0.96 1056 2.2 28.2 0.69 1575 1.6 24.8 0.53 2635
SD(D) 0.3 0.4 0.04 341 0.2 0.12 207 0.5 0.18 402
CV(E) 8.8 12.2 4.0 32.3 10.4 17.3 13.1 31.1 34.3 15.2
14 TO 52 WEEKS
----------------
MEAN 3.5 48.7 3.2 48.6 0.92 657 2.8 47.4 0.80 1176 2.4 41.9 0.69 2296
SD(D) 0.4 0.3 0.04 25 0.2 0.06 74 0.1 0.08 186
CV(E) 11.4 7.9 4.4 3.8 6.2 7.1 6.3 4.7 11.2 8.1
> 52 WEEKS
----------------
MEAN 4.3 52.4 3.7 52.4 0.87 714 3.0 51.0 0.69 1174 2.7 44.3 0.61 2408
SD(D) 0.1 0.1 0.04 25 0.1 0.04 53 0.3 0.08 182
CV(E) 3.1 3.9 4.3 3.5 3.4 5.1 4.5 11.7 12.3 7.6
==================================================================================================================================
(A) GRAMS OF WATER CONSUMED PER ANIMAL PER DAY.
(B) GRAMS OF WATER PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.
(D) STANDARD DEVIATION OF WEEKLY MEAN.
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.
WATER AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE
CHRONIC DOSED WATER STUDY OF DIPROPYLENE GLYCOL
==================================================================================================================================
0.0% 1.0% 2.0% 4.0%
---------------- --------------------------------- --------------------------------- ---------------------------------
DOSE/ DOSE/ DOSE/
GRAMS BODY GRAMS BODY CONTROL GRAMS BODY CONTROL GRAMS BODY CONTROL
WATER/ WEIGHT WATER/ WEIGHT WATER (B) DOSE/ WATER/ WEIGHT WATER (B) DOSE/ WATER/ WEIGHT WATER (B) DOSE/
WEEK DAY(A) (GRAMS) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C)
==================================================================================================================================
1 3.0 18.2 2.8 18.3 0.93 1549 2.0 18.3 0.67 2139 1.1 18.3 0.37 2316
2 2.8 19.2 2.7 19.1 0.96 1432 2.0 18.6 0.71 2140 1.3 17.0 0.46 2968
6 2.6 22.7 2.7 23.5 1.04 1152 2.3 22.2 0.88 2039 1.9 22.0 0.73 3479
10 2.6 27.4 2.5 27.8 0.96 904 2.2 26.4 0.85 1669 2.0 26.4 0.77 3058
14 3.0 32.7 2.5 33.3 0.83 756 2.4 32.3 0.80 1467 2.2 32.4 0.73 2766
18 2.5 38.0 2.5 38.4 1.00 651 2.3 36.8 0.92 1231 2.3 36.6 0.92 2468
22 2.5 43.0 2.9 43.2 1.16 683 2.8 41.1 1.12 1377 2.3 41.1 0.92 2191
26 2.5 45.7 2.4 46.3 0.96 518 2.2 43.7 0.88 1015 2.4 44.3 0.96 2143
30 2.5 48.1 2.5 47.7 1.00 520 2.4 46.1 0.96 1025 2.5 46.5 1.00 2118
34 2.5 51.5 2.4 51.1 0.96 476 2.3 49.2 0.92 935 2.6 49.9 1.04 2086
38 2.4 54.3 2.4 53.8 1.00 446 2.3 52.6 0.96 886 2.4 52.2 1.00 1811
42 2.4 56.3 2.4 55.9 1.00 430 2.7 54.7 1.13 972 2.5 54.5 1.04 1822
46 2.2 57.7 2.7 57.2 1.23 472 2.1 55.8 0.95 747 2.0 55.4 0.91 1479
50 2.3 59.6 2.2 58.5 0.96 369 2.1 58.2 0.91 710 2.1 57.2 0.91 1490
54 2.5 60.6 2.2 59.6 0.88 378 2.2 59.2 0.88 748 2.2 57.8 0.88 1531
58 2.7 60.5 2.5 60.4 0.93 410 2.3 58.8 0.85 774 2.3 57.0 0.85 1629
62 2.5 61.3 2.6 59.4 1.04 431 2.2 59.5 0.88 731 2.2 57.7 0.88 1496
66 2.5 61.4 2.4 60.0 0.96 397 2.3 59.0 0.92 776 2.3 57.7 0.92 1586
70 2.5 60.4 2.3 59.7 0.92 389 2.1 57.8 0.84 735 2.0 56.7 0.80 1445
74 4.2 60.7 2.8 59.2 0.67 472 2.5 58.5 0.60 867 3.1 56.4 0.74 2163
78 2.5 61.3 2.1 58.0 0.84 369 1.9 58.8 0.76 653 1.9 55.5 0.76 1370
82 2.5 61.1 2.3 60.2 0.92 390 2.6 59.6 1.04 859 2.7 56.6 1.08 1930
86 2.8 59.7 2.6 56.6 0.93 464 2.2 56.9 0.79 779 2.3 54.4 0.82 1684
90 2.9 57.7 2.4 53.9 0.83 449 2.5 55.9 0.86 884 2.0 50.5 0.69 1596
94 3.4 55.4 2.5 51.4 0.74 487 2.5 53.7 0.74 916 1.8 47.2 0.53 1506
98 3.5 53.4 2.4 51.0 0.69 467 2.4 54.4 0.69 882 1.7 45.7 0.49 1517
102 3.7 52.4 2.6 51.0 0.70 518 2.5 53.2 0.68 957 2.0 45.2 0.54 1746
1 TO 13 WEEKS
----------------
MEAN 2.8 21.9 2.7 22.2 0.97 1259 2.1 21.4 0.78 1997 1.6 20.9 0.58 2955
SD(D) 0.2 0.1 0.04 290 0.2 0.10 224 0.5 0.20 481
CV(E) 6.9 5.1 4.6 23.0 7.1 13.4 11.2 30.4 33.9 16.3
14 TO 52 WEEKS
----------------
MEAN 2.5 48.7 2.5 48.5 1.01 532 2.3 47.1 0.96 1037 2.3 47.0 0.94 2037
SD(D) 0.2 0.2 0.11 124 0.2 0.10 251 0.2 0.09 404
CV(E) 8.4 8.4 10.9 23.3 10.1 10.5 24.2 7.3 9.5 19.8
> 52 WEEKS
----------------
MEAN 2.9 58.9 2.5 57.0 0.85 432 2.3 57.3 0.81 812 2.2 53.7 0.77 1631
SD(D) 0.6 0.2 0.12 47 0.2 0.12 88 0.4 0.17 214
CV(E) 19.0 7.2 13.9 10.9 8.3 14.7 10.8 16.8 22.3 13.2
==================================================================================================================================
(A) GRAMS OF WATER CONSUMED PER ANIMAL PER DAY.
(B) GRAMS OF WATER PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.
(D) STANDARD DEVIATION OF WEEKLY MEAN.
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.
DIAGNOSTIC TRAILER REPORT
WATER AND COMPOUND CONSUMPTION BY MALE MICE IN THE
CHRONIC DOSED WATER STUDY OF DIPROPYLENE GLYCOL
=========================================================================================================
0.0% 1.0% 2.0% 4.0%
---------------------- ---------------------- ---------------------- ----------------------
DAILY WATER BODY NUM DAILY WATER BODY NUM DAILY WATER BODY NUM DAILY WATER BODY NUM
WEEK WATER HOURS WGT WGTS WATER HOURS WGT WGTS WATER HOURS WGT WGTS WATER HOURS WGT WGTS
==========================================================================================================
B 22.5 50 22.6 50 22.5 50 22.6 50
1 22.5 50 22.6 50 22.5 50 22.6 50
2 3.4 8302 23.7 50 3.4 8295 24.1 50 1.9 8090 22.1 50 1.1 8256 18.2 50
6 3.2 8346 29.7 50 3.0 8315 29.9 50 2.3 8273 28.5 50 2.0 8106 25.6 50
10 2.9 8379 35.8 50 2.7 8408 35.9 50 2.3 8196 34.2 50 1.9 8374 30.5 50
14 2.9 8247 40.4 50 2.8 8458 40.6 50 2.6 8201 38.5 50 2.2 8445 34.3 50
18 3.0 8467 44.6 50 2.9 8301 45.0 50 2.5 8487 42.5 50 2.3 7956 37.9 50
22 3.1 8218 46.7 50 2.9 7951 46.6 50 2.6 8119 45.0 50 2.5 7718 41.0 50
26 3.4 8421 48.1 50 3.3 8367 48.1 50 2.9 7761 46.7 50 2.5 7240 42.0 50
30 3.3 8411 49.3 50 3.0 8360 48.7 50 2.7 8425 48.2 50 2.4 8057 43.5 50
34 3.7 8169 50.2 50 3.4 8132 49.9 49 3.0 8408 48.9 50 2.5 8174 43.5 50
38 3.7 7700 51.3 50 3.3 8123 50.9 49 2.9 8277 50.2 50 2.4 8222 44.3 50
42 3.8 8589 51.6 50 3.3 8389 51.2 49 2.9 8258 50.6 50 2.3 8397 43.9 50
46 4.0 8271 52.5 50 3.5 8292 52.1 49 3.0 8245 51.4 50 2.5 7941 44.0 50
50 4.0 7966 52.8 50 3.5 8305 52.4 49 2.8 8393 51.9 50 2.3 7381 44.6 50
54 4.3 8256 53.1 50 3.6 8250 52.5 49 3.1 8424 52.1 50 2.6 8256 45.7 49
58 4.3 8169 53.1 50 3.7 8130 52.8 49 3.0 8359 51.8 50 2.6 8173 45.6 49
62 4.4 8192 53.9 49 3.7 7669 53.8 47 2.9 8240 52.4 50 2.7 7681 47.3 47
66 4.4 7569 53.9 49 4.1 7735 53.8 47 3.2 8252 52.5 50 3.0 7400 48.1 46
70 4.2 7773 53.5 49 3.8 7854 53.6 47 3.0 8295 52.0 50 3.0 7330 47.8 45
74 4.3 7837 52.4 49 3.7 7575 53.6 45 2.8 8093 51.6 49 3.0 7258 46.6 45
78 4.4 7951 52.5 49 3.9 7615 53.0 45 3.0 8107 51.6 48 2.9 7107 47.2 42
82 4.5 7713 53.1 47 3.7 7031 53.4 44 3.0 7865 52.4 47 3.0 7003 46.2 42
86 4.5 7370 53.2 45 3.8 6987 52.5 43 3.0 7183 50.4 46 2.4 6143 43.4 41
90 4.5 7368 52.6 44 3.7 7026 52.0 42 2.8 7534 49.3 45 2.0 6711 41.4 40
94 4.2 6477 51.5 43 3.9 6667 51.1 42 3.1 6417 48.7 42 2.6 5557 40.0 40
98 4.1 6509 50.3 42 3.6 6868 50.4 41 2.9 6352 49.8 38 2.5 6181 39.6 37
102 4.3 6692 48.6 42 3.6 6713 49.1 40 3.1 6064 48.4 37 2.3 6038 37.3 36
=========================================================================================================
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
DIAGNOSTIC TRAILER REPORT
WATER AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE
CHRONIC DOSED WATER STUDY OF DIPROPYLENE GLYCOL
=========================================================================================================
0.0% 1.0% 2.0% 4.0%
---------------------- ---------------------- ---------------------- ----------------------
DAILY WATER BODY NUM DAILY WATER BODY NUM DAILY WATER BODY NUM DAILY WATER BODY NUM
WEEK WATER HOURS WGT WGTS WATER HOURS WGT WGTS WATER HOURS WGT WGTS WATER HOURS WGT WGTS
==========================================================================================================
B 18.2 50 18.3 50 18.3 50 18.3 50
1 3.0 3434 18.2 50 2.8 3440 18.3 50 2.0 3334 18.3 50 1.1 3429 18.3 50
2 2.8 4792 19.2 50 2.7 4735 19.1 50 2.0 4305 18.6 50 1.3 4845 17.0 50
5 2.7 3448 2.6 3585 2.3 3234 1.9 3526
6 2.6 4887 22.7 50 2.7 4135 23.5 50 2.3 4914 22.2 50 1.9 4829 22.0 49
9 2.8 3483 2.8 3493 2.4 3510 2.2 3464
10 2.6 4906 27.4 50 2.5 4931 27.8 50 2.2 4452 26.4 50 2.0 4632 26.4 49
13 2.9 3634 2.8 3648 2.7 2907 2.5 2770
14 3.0 4802 32.7 50 2.5 4832 33.3 50 2.4 4761 32.3 50 2.2 3504 32.4 49
17 2.7 3354 2.8 3146 2.5 3006 3.1 3285
18 2.5 4562 38.0 50 2.5 4388 38.4 50 2.3 4357 36.8 50 2.3 4833 36.6 49
21 2.5 3648 2.3 3280 2.7 3305 2.4 3626
22 2.5 4727 43.0 50 2.9 4810 43.2 50 2.8 4760 41.1 50 2.3 4143 41.1 49
25 2.4 3520 2.3 3550 2.2 3554 2.3 3473
26 2.5 4825 45.7 50 2.4 4810 46.3 50 2.2 4751 43.7 50 2.4 4289 44.3 49
29 2.7 3453 2.6 3282 2.5 3519 2.6 3106
30 2.5 4756 48.1 49 2.5 4862 47.7 50 2.4 4841 46.1 50 2.5 4484 46.5 49
33 2.7 3431 2.7 3495 2.7 3495 2.6 3410
34 2.5 4777 51.5 49 2.4 4850 51.1 50 2.3 4805 49.2 50 2.6 4601 49.9 48
37 2.6 3493 2.6 3574 2.4 3589 2.5 3411
38 2.4 4655 54.3 49 2.4 4731 53.8 50 2.3 4700 52.6 50 2.4 4539 52.2 48
41 2.3 3564 2.3 3632 2.4 3595 2.3 3443
42 2.4 4168 56.3 49 2.4 4676 55.9 50 2.7 4247 54.7 50 2.5 4574 54.5 48
45 2.6 3394 2.4 3546 2.5 3540 2.6 3358
46 2.2 4854 57.7 49 2.7 4840 57.2 50 2.1 4537 55.8 50 2.0 4085 55.4 48
49 2.4 3471 2.4 3512 2.2 3514 2.4 3385
50 2.3 4831 59.6 49 2.2 4998 58.5 50 2.1 4767 58.2 49 2.1 4716 57.2 48
53 2.6 3433 2.5 3535 2.6 3474 2.5 3388
54 2.5 4891 60.6 49 2.2 4182 59.6 50 2.2 4876 59.2 49 2.2 4767 57.8 48
57 2.9 3381 2.4 3455 2.4 3373 2.5 3282
58 2.7 4353 60.5 49 2.5 4744 60.4 50 2.3 4072 58.8 49 2.3 4685 57.0 47
61 2.6 3641 2.4 3732 2.1 3575 2.3 3117
62 2.5 4485 61.3 49 2.6 4501 59.4 50 2.2 4432 59.5 48 2.2 3439 57.7 47
65 2.7 3454 2.5 3557 2.4 2693 2.3 2620
66 2.5 4260 61.4 49 2.4 4836 60.0 50 2.3 4175 59.0 48 2.3 4495 57.7 46
69 2.5 3281 2.4 3371 2.5 2765 2.2 2761
70 2.5 4789 60.4 49 2.3 4395 59.7 50 2.1 3975 57.8 47 2.0 3165 56.7 46
73 2.6 3380 2.5 3472 2.2 3308 2.3 2843
74 4.2 4126 60.7 48 2.8 2688 59.2 49 2.5 2448 58.5 47 3.1 2362 56.4 43
77 2.5 3451 2.4 3494 2.5 3302 2.6 2457
78 2.5 4641 61.3 48 2.1 4300 58.0 49 1.9 4446 58.8 46 1.9 3162 55.5 43
81 2.8 3465 2.4 3371 2.4 3249 2.3 2749
82 2.5 4628 61.1 48 2.3 4088 60.2 47 2.6 4336 59.6 45 2.7 3094 56.6 37
85 2.9 3431 2.5 3377 2.1 3138 2.4 2322
86 2.8 4507 59.7 47 2.6 4095 56.6 46 2.2 3757 56.9 43 2.3 2676 54.4 37
89 2.9 3095 2.9 2925 2.3 2099 2.6 2493
90 2.9 4334 57.7 45 2.4 4076 53.9 46 2.5 3559 55.9 42 2.0 2664 50.5 37
93 3.4 3051 3.0 3037 2.7 2631 2.0 2552
94 3.4 4232 55.4 43 2.5 3652 51.4 44 2.5 3320 53.7 42 1.8 2333 47.2 36
97 3.1 2880 2.5 3078 2.5 2876 2.2 1666
=========================================================================================================
DIAGNOSTIC TRAILER REPORT
WATER AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE
CHRONIC DOSED WATER STUDY OF DIPROPYLENE GLYCOL
=========================================================================================================
0.0% 1.0% 2.0% 4.0%
---------------------- ---------------------- ---------------------- ----------------------
DAILY WATER BODY NUM DAILY WATER BODY NUM DAILY WATER BODY NUM DAILY WATER BODY NUM
WEEK WATER HOURS WGT WGTS WATER HOURS WGT WGTS WATER HOURS WGT WGTS WATER HOURS WGT WGTS
==========================================================================================================
98 3.5 3747 53.4 43 2.4 3664 51.0 43 2.4 3827 54.4 40 1.7 3326 45.7 35
101 3.9 2437 3.0 2653 3.1 2595 2.6 2202
102 3.7 3742 52.4 39 2.6 3360 51.0 40 2.5 3752 53.2 38 2.0 3181 45.2 33
MEAN BODY WGT FOR WEEKS
1 TO 13 21.9 22.2 21.4 20.9
14 TO 52 48.7 48.5 47.1 47.0
> 52 58.9 57.0 57.3 53.7
=========================================================================================================
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.