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TDMS Study 88031-06 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Columbus                                     DIPROPYLENE GLYCOL                                  DATE: 06/26/02       
EXPERIMENT: 88031 TEST: 06                                                                                     TIME: 14:00:57       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-55388                              ROUTE: DOSED WATER                                             NTP C#: C88031       
PATHOLOGIST: RYAN, MICHAEL                                                                                     CAS: 25265-71-8      
------------------------------------------------------------------------------------------------------------------------------------
                                                        FINAL#1, REVISION #3                                                        
               REASONS FOR REMOVAL:    25022 Accidently Killed                                                                      
                                       25018 Dosing Accident                                                                        
                                       25019 Moribund Sacrifice                                                                     
                                       25020 Natural Death                                                                          
                                       25026 Other                                                                                  
                                       25021 Terminal Sacrifice                                                                     
               REMOVAL DATE RANGE:     ALL                                                                                          
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Columbus                                     DIPROPYLENE GLYCOL                                  DATE: 06/26/02       
EXPERIMENT: 88031 TEST: 06                                                                                     TIME: 14:00:57       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-55388                              ROUTE: DOSED WATER                                             NTP C#: C88031       
PATHOLOGIST: RYAN, MICHAEL                                                                                     CAS: 25265-71-8      
Mice(B6C3F1)                                                                                                                        
-----------------------------                                                                                                       
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE                                                                   
BASED ON NUMBER OF TISSUES EXAMINED.  IN OTHER TISSUES/ORGANS RATES                                                                 
ARE BASED ON THE NUMBER OF ANIMALS NECROPSIED.                                                                                      
                                                 ---------------                                                                    
                                                 Adrenal Medulla                                                                    
                                                 Bone Marrow                                                                        
                                                 Clitoral/Preputial Gland                                                           
                                                 Islets, Pancreatic                                                                 
                                                 Kidney                                                                             
                                                 Liver                                                                              
                                                 Lung                                                                               
                                                 Nose                                                                               
                                                 Ovary                                                                              
                                                 Pituitary Gland                                                                    
                                                 Spleen                                                                             
                                                 Testes                                                                             
                                                 Thymus                                                                             
                                                 Thyroid Gland                                                                      
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Columbus                                     DIPROPYLENE GLYCOL                                  DATE: 06/26/02       
EXPERIMENT: 88031 TEST: 06                                                                                     TIME: 14:00:57       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-55388                              ROUTE: DOSED WATER                                             NTP C#: C88031       
PATHOLOGIST: RYAN, MICHAEL                                                                                     CAS: 25265-71-8      
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF                DIPROPYLENE GLYCOL                                                                                
===============================================================                                                                     
Male Mice                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Liver                                  Hepatocellular Adenoma                                                                       
Lung                                   Alveolar/Bronchiolar Adenoma                                                                 
                                       Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                               
All Organs                             Benign Tumors                                                                                
                                       Malignant Tumors                                                                             
===============================================================                                                                     
Female Mice                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
                                       Hemangiosarcoma                                                                              
===============================================================                                                                     
       Date:  06/26/02                           EXPERIMENT: 88031 TEST: 06                                            Page 1       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)        -                 DIPROPYLENE GLYCOL             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    0/50 (0%)    0/49 (0%)   |0/50 (0%)    0/49 (0%)    2/49 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/45.94      0/43.93      0/45.14      0/41.99     |0/45.83      0/45.33      2/44.15      1/40.93      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         4.5%         2.4%         | 
|TERMINAL (d)       |     0/40 (0%)    0/39 (0%)    0/35 (0%)    0/34 (0%)   |0/37 (0%)    0/37 (0%)    1/38 (3%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          693          395          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.220      (e)          P=0.237      P=0.496      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.203      (e)          P=0.229      P=0.477      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.216      (e)          P=0.231      P=0.485      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.192      (e)          P=0.228      P=0.471      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.337      (e)          P=0.230      P=0.652      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.247      (e)          P=0.242      P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    3/50 (6%)    4/50 (8%)    1/49 (2%)   |1/50 (2%)    2/50 (4%)    2/50 (4%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     2/45.94      3/44.17      4/45.14      1/41.99     |1/45.83      2/46.65      2/44.12      3/40.09      | 
|POLY-3 PERCENT (g) |     4.4%         6.8%         8.9%         2.4%        |2.2%         4.3%         4.5%         7.5%         | 
|TERMINAL (d)       |     2/40 (5%)    2/39 (5%)    4/35 (11%)   1/34 (3%)   |1/37 (3%)    1/38 (3%)    2/38 (5%)    3/33 (9%)    | 
|FIRST INCIDENCE    |     729 (T)      710          729 (T)      729 (T)     |728 (T)      641          728 (T)      728 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.451N     P=0.489      P=0.277      P=0.557N    |P=0.186      P=0.509      P=0.509      P=0.265      | 
|POLY 3             |     P=0.416N     P=0.482      P=0.329      P=0.531N    |P=0.184      P=0.506      P=0.487      P=0.259      | 
|POLY 1.5           |     P=0.402N     P=0.486      P=0.334      P=0.522N    |P=0.199      P=0.505      P=0.492      P=0.274      | 
|POLY 6             |     P=0.432N     P=0.482      P=0.320      P=0.540N    |P=0.172      P=0.507      P=0.483      P=0.246      | 
|LOGISTIC REGRESSION|     P=0.437N     P=0.481      P=0.277      P=0.557N    |P=0.175      P=0.498      P=0.509      P=0.265      | 
|COCH-ARM / FISHERS |     P=0.380N     P=0.500      P=0.339      P=0.508N    |P=0.232      P=0.500      P=0.500      P=0.309      | 
|=================================================================================================================================| 
       Date:  06/26/02                           EXPERIMENT: 88031 TEST: 06                                            Page 2       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 DIPROPYLENE GLYCOL              
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    3/50 (6%)    4/50 (8%)    1/49 (2%)   |1/50 (2%)    3/50 (6%)    2/50 (4%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     3/45.94      3/44.17      4/45.14      1/41.99     |1/45.83      3/46.65      2/44.12      3/40.09      | 
|POLY-3 PERCENT (g) |     6.5%         6.8%         8.9%         2.4%        |2.2%         6.4%         4.5%         7.5%         | 
|TERMINAL (d)       |     3/40 (8%)    2/39 (5%)    4/35 (11%)   1/34 (3%)   |1/37 (3%)    2/38 (5%)    2/38 (5%)    3/33 (9%)    | 
|FIRST INCIDENCE    |     729 (T)      710          729 (T)      729 (T)     |728 (T)      641          728 (T)      728 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.320N     P=0.650      P=0.427      P=0.365N    |P=0.248      P=0.316      P=0.509      P=0.265      | 
|POLY 3             |     P=0.285N     P=0.644      P=0.490      P=0.338N    |P=0.242      P=0.312      P=0.487      P=0.259      | 
|POLY 1.5           |     P=0.273N     P=0.648      P=0.496      P=0.329N    |P=0.261      P=0.311      P=0.492      P=0.274      | 
|POLY 6             |     P=0.297N     P=0.644      P=0.480      P=0.347N    |P=0.226      P=0.312      P=0.483      P=0.246      | 
|LOGISTIC REGRESSION|     P=0.307N     P=0.645      P=0.427      P=0.365N    |P=0.231      P=0.307      P=0.509      P=0.265      | 
|COCH-ARM / FISHERS |     P=0.255N     P=0.661N     P=0.500      P=0.316N    |P=0.302      P=0.309      P=0.500      P=0.309      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Small: Duodenum                                                                                                        | 
|     Polyp Adenomatous                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    0/50 (0%)    0/49 (0%)   |0/50 (0%)    1/50 (2%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/45.94      2/44.10      0/45.14      0/41.99     |0/45.83      1/46.33      1/44.12      0/40.09      | 
|POLY-3 PERCENT (g) |     2.2%         4.5%         0.0%         0.0%        |0.0%         2.2%         2.3%         0.0%         | 
|TERMINAL (d)       |     1/40 (3%)    2/39 (5%)    0/35 (0%)    0/34 (0%)   |0/37 (0%)    1/38 (3%)    1/38 (3%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          ---         |---          728 (T)      728 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.218N     P=0.491      P=0.527N     P=0.532N    |P=0.622N     P=0.505      P=0.505      (e)          | 
|POLY 3             |     P=0.200N     P=0.486      P=0.504N     P=0.518N    |P=0.629N     P=0.502      P=0.492      (e)          | 
|POLY 1.5           |     P=0.196N     P=0.489      P=0.502N     P=0.513N    |P=0.618N     P=0.502      P=0.496      (e)          | 
|POLY 6             |     P=0.203N     P=0.485      P=0.507N     P=0.523N    |P=0.639N     P=0.502      P=0.490      (e)          | 
|LOGISTIC REGRESSION|     P=0.218N     P=0.491      (e)          (e)         |(e)          P=0.505      P=0.505      (e)          | 
|COCH-ARM / FISHERS |     P=0.191N     P=0.500      P=0.500N     P=0.505N    |P=0.595N     P=0.500      P=0.500      (e)          | 
|=================================================================================================================================| 
       Date:  06/26/02                           EXPERIMENT: 88031 TEST: 06                                            Page 3       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 DIPROPYLENE GLYCOL              
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Small: Jejunum                                                                                                         | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    3/50 (6%)    0/49 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/45.94      2/44.10      3/45.14      0/41.99     |0/45.83      0/46.33      0/44.12      0/40.09      | 
|POLY-3 PERCENT (g) |     2.2%         4.5%         6.7%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/40 (3%)    2/39 (5%)    3/35 (9%)    0/34 (0%)   |0/37 (0%)    0/38 (0%)    0/38 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.396N     P=0.491      P=0.258      P=0.532N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.375N     P=0.486      P=0.299      P=0.518N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.363N     P=0.489      P=0.303      P=0.513N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.387N     P=0.485      P=0.292      P=0.523N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.396N     P=0.491      P=0.258      (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.344N     P=0.500      P=0.309      P=0.505N    |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Small: Site Unspecified                                                                                                | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    3/50 (6%)    0/49 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/45.94      2/44.10      3/45.14      0/41.99     |0/45.83      0/46.33      0/44.12      0/40.09      | 
|POLY-3 PERCENT (g) |     2.2%         4.5%         6.7%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/40 (3%)    2/39 (5%)    3/35 (9%)    0/34 (0%)   |0/37 (0%)    0/38 (0%)    0/38 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.396N     P=0.491      P=0.258      P=0.532N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.375N     P=0.486      P=0.299      P=0.518N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.363N     P=0.489      P=0.303      P=0.513N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.387N     P=0.485      P=0.292      P=0.523N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.396N     P=0.491      P=0.258      (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.344N     P=0.500      P=0.309      P=0.505N    |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  06/26/02                           EXPERIMENT: 88031 TEST: 06                                            Page 4       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 DIPROPYLENE GLYCOL              
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Small: Site Unspecified                                                                                                | 
|     Polyp Adenomatous                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    3/50 (6%)    0/50 (0%)    0/49 (0%)   |0/50 (0%)    1/50 (2%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/45.94      3/44.10      0/45.14      0/41.99     |0/45.83      1/46.33      1/44.12      0/40.09      | 
|POLY-3 PERCENT (g) |     4.4%         6.8%         0.0%         0.0%        |0.0%         2.2%         2.3%         0.0%         | 
|TERMINAL (d)       |     2/40 (5%)    3/39 (8%)    0/35 (0%)    0/34 (0%)   |0/37 (0%)    1/38 (3%)    1/38 (3%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          ---         |---          728 (T)      728 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.093N     P=0.488      P=0.268N     P=0.275N    |P=0.622N     P=0.505      P=0.505      (e)          | 
|POLY 3             |     P=0.079N     P=0.481      P=0.241N     P=0.258N    |P=0.629N     P=0.502      P=0.492      (e)          | 
|POLY 1.5           |     P=0.077N     P=0.485      P=0.239N     P=0.252N    |P=0.618N     P=0.502      P=0.496      (e)          | 
|POLY 6             |     P=0.082N     P=0.481      P=0.245N     P=0.263N    |P=0.639N     P=0.502      P=0.490      (e)          | 
|LOGISTIC REGRESSION|     P=0.093N     P=0.488      (e)          (e)         |(e)          P=0.505      P=0.505      (e)          | 
|COCH-ARM / FISHERS |     P=0.075N     P=0.500      P=0.247N     P=0.253N    |P=0.595N     P=0.500      P=0.500      (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/50 (2%)    0/49 (0%)   |2/50 (4%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/45.94      0/44.10      1/45.45      0/41.99     |2/45.83      0/46.33      0/44.12      1/40.93      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.2%         0.0%        |4.4%         0.0%         0.0%         2.4%         | 
|TERMINAL (d)       |     0/40 (0%)    0/39 (0%)    0/35 (0%)    0/34 (0%)   |2/37 (5%)    0/38 (0%)    0/38 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          645          ---         |728 (T)      ---          ---          395          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.688      (e)          P=0.505      (e)         |P=0.483N     P=0.232N     P=0.232N     P=0.529N     | 
|POLY 3             |     P=0.665      (e)          P=0.498      (e)         |P=0.461N     P=0.235N     P=0.246N     P=0.539N     | 
|POLY 1.5           |     P=0.676      (e)          P=0.499      (e)         |P=0.462N     P=0.235N     P=0.242N     P=0.527N     | 
|POLY 6             |     P=0.655      (e)          P=0.495      (e)         |P=0.459N     P=0.235N     P=0.248N     P=0.551N     | 
|LOGISTIC REGRESSION|     P=0.702      (e)          P=0.493      (e)         |P=0.375N     (e)          (e)          P=0.439N     | 
|COCH-ARM / FISHERS |     P=0.692      (e)          P=0.500      (e)         |P=0.461N     P=0.247N     P=0.247N     P=0.500N     | 
|=================================================================================================================================| 
       Date:  06/26/02                           EXPERIMENT: 88031 TEST: 06                                            Page 5       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 DIPROPYLENE GLYCOL              
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hemangioma                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    2/50 (4%)    0/49 (0%)   |1/50 (2%)    0/50 (0%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/45.94      1/44.10      2/45.14      0/41.99     |1/45.83      0/46.33      1/44.12      1/40.09      | 
|POLY-3 PERCENT (g) |     2.2%         2.3%         4.4%         0.0%        |2.2%         0.0%         2.3%         2.5%         | 
|TERMINAL (d)       |     1/40 (3%)    1/39 (3%)    2/35 (6%)    0/34 (0%)   |1/37 (3%)    0/38 (0%)    1/38 (3%)    1/33 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      ---         |728 (T)      ---          728 (T)      728 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.415N     P=0.756      P=0.453      P=0.532N    |P=0.509      P=0.495N     P=0.756N     P=0.736      | 
|POLY 3             |     P=0.393N     P=0.751      P=0.494      P=0.518N    |P=0.495      P=0.498N     P=0.752      P=0.730      | 
|POLY 1.5           |     P=0.385N     P=0.753      P=0.497      P=0.513N    |P=0.508      P=0.498N     P=0.756      P=0.740      | 
|POLY 6             |     P=0.402N     P=0.751      P=0.487      P=0.523N    |P=0.483      P=0.498N     P=0.750      P=0.721      | 
|LOGISTIC REGRESSION|     P=0.415N     P=0.756      P=0.453      (e)         |P=0.509      (e)          P=0.756N     P=0.736      | 
|COCH-ARM / FISHERS |     P=0.372N     P=0.753N     P=0.500      P=0.505N    |P=0.539      P=0.500N     P=0.753N     P=0.753N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    3/50 (6%)    1/50 (2%)    2/49 (4%)   |2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/45.94      3/44.10      1/45.15      2/41.99     |2/45.83      0/46.33      0/44.12      0/40.09      | 
|POLY-3 PERCENT (g) |     0.0%         6.8%         2.2%         4.8%        |4.4%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/40 (0%)    3/39 (8%)    0/35 (0%)    2/34 (6%)   |2/37 (5%)    0/38 (0%)    0/38 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      727          729 (T)     |728 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.280      P=0.117      P=0.479      P=0.203     |P=0.122N     P=0.232N     P=0.232N     P=0.264N     | 
|POLY 3             |     P=0.299      P=0.111      P=0.497      P=0.218     |P=0.111N     P=0.235N     P=0.246N     P=0.268N     | 
|POLY 1.5           |     P=0.310      P=0.113      P=0.498      P=0.223     |P=0.112N     P=0.235N     P=0.242N     P=0.258N     | 
|POLY 6             |     P=0.289      P=0.111      P=0.493      P=0.212     |P=0.109N     P=0.235N     P=0.248N     P=0.278N     | 
|LOGISTIC REGRESSION|     P=0.278      P=0.117      P=0.482      P=0.203     |P=0.122N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.330      P=0.121      P=0.500      P=0.242     |P=0.115N     P=0.247N     P=0.247N     P=0.247N     | 
|=================================================================================================================================| 
       Date:  06/26/02                           EXPERIMENT: 88031 TEST: 06                                            Page 6       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 DIPROPYLENE GLYCOL              
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatoblastoma                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    4/50 (8%)    1/49 (2%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/45.94      0/44.10      4/46.37      1/42.22     |0/45.83      0/46.33      1/44.26      0/40.09      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         8.6%         2.4%        |0.0%         0.0%         2.3%         0.0%         | 
|TERMINAL (d)       |     0/40 (0%)    0/39 (0%)    0/35 (0%)    0/34 (0%)   |0/37 (0%)    0/38 (0%)    0/38 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          616          668         |---          ---          693          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.223      (e)          P=0.068      P=0.480     |P=0.671      (e)          P=0.490      (e)          | 
|POLY 3             |     P=0.207      (e)          P=0.061      P=0.483     |P=0.634      (e)          P=0.493      (e)          | 
|POLY 1.5           |     P=0.218      (e)          P=0.061      P=0.488     |P=0.654      (e)          P=0.496      (e)          | 
|POLY 6             |     P=0.197      (e)          P=0.061      P=0.479     |P=0.616      (e)          P=0.492      (e)          | 
|LOGISTIC REGRESSION|     P=0.261      (e)          P=0.056      P=0.514     |P=0.693      (e)          P=0.500      (e)          | 
|COCH-ARM / FISHERS |     P=0.239      (e)          P=0.059      P=0.495     |P=0.694      (e)          P=0.500      (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Adenoma                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     17/50 (34%)  17/50 (34%)  20/50 (40%)  6/49 (12%)  |11/50 (22%)  14/50 (28%)  12/50 (24%)  11/50 (22%)  | 
|POLY-3 RATE (b)    |     17/46.41     17/44.10     20/46.26     6/42.99     |11/46.08     14/46.65     12/44.12     11/40.68     | 
|POLY-3 PERCENT (g) |     36.6%        38.6%        43.2%        14.0%       |23.9%        30.0%        27.2%        27.0%        | 
|TERMINAL (d)       |     16/40 (40%)  17/39 (44%)  17/35 (49%)  4/34 (12%)  |9/37 (24%)   12/38 (32%)  12/38 (32%)  10/33 (30%)  | 
|FIRST INCIDENCE    |     592          729 (T)      542          464         |693          687          728 (T)      542          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.029N*    P=0.548      P=0.187      P=0.025N*   |P=0.485      P=0.347      P=0.522      P=0.466      | 
|POLY 3             |     P=0.011N*    P=0.511      P=0.330      P=0.012N*   |P=0.468      P=0.333      P=0.452      P=0.464      | 
|POLY 1.5           |     P=0.010N*    P=0.530      P=0.337      P=0.010N*   |P=0.520      P=0.334      P=0.472      P=0.507      | 
|POLY 6             |     P=0.013N*    P=0.501      P=0.314      P=0.013N*   |P=0.421      P=0.330      P=0.434      P=0.424      | 
|LOGISTIC REGRESSION|     P=0.015N*    P=0.528      P=0.305      P=0.014N*   |P=0.412      P=0.327      P=0.452      P=0.421      | 
|COCH-ARM / FISHERS |     P=0.010N*    P=0.583N     P=0.339      P=0.009N**  |P=0.455N     P=0.322      P=0.500      P=0.595N     | 
|=================================================================================================================================| 
       Date:  06/26/02                           EXPERIMENT: 88031 TEST: 06                                            Page 7       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 DIPROPYLENE GLYCOL              
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     14/50 (28%)  10/50 (20%)  11/50 (22%)  16/49 (33%) |7/50 (14%)   2/50 (4%)    2/50 (4%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     14/49.44     10/46.13     11/46.50     16/45.31    |7/46.24      2/46.33      2/44.12      2/40.68      | 
|POLY-3 PERCENT (g) |     28.3%        21.7%        23.7%        35.3%       |15.1%        4.3%         4.5%         4.9%         | 
|TERMINAL (d)       |     5/40 (13%)   5/39 (13%)   6/35 (17%)   7/34 (21%)  |5/37 (14%)   2/38 (5%)    2/38 (5%)    1/33 (3%)    | 
|FIRST INCIDENCE    |     416          501          616          451         |621          728 (T)      728 (T)      542          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.175      P=0.299N     P=0.410N     P=0.286     |P=0.090N     P=0.079N     P=0.082N     P=0.121N     | 
|POLY 3             |     P=0.200      P=0.306N     P=0.388N     P=0.306     |P=0.081N     P=0.078N     P=0.090N     P=0.113N     | 
|POLY 1.5           |     P=0.217      P=0.287N     P=0.360N     P=0.334     |P=0.076N     P=0.077N     P=0.086N     P=0.101N     | 
|POLY 6             |     P=0.183      P=0.319N     P=0.425N     P=0.282     |P=0.085N     P=0.080N     P=0.094N     P=0.125N     | 
|LOGISTIC REGRESSION|     P=0.303      P=0.160N     P=0.288N     P=0.549     |P=0.081N     P=0.078N     P=0.090N     P=0.095N     | 
|COCH-ARM / FISHERS |     P=0.243      P=0.241N     P=0.322N     P=0.388     |P=0.066N     P=0.080N     P=0.080N     P=0.080N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma or Hepatoblastoma                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     14/50 (28%)  10/50 (20%)  13/50 (26%)  16/49 (33%) |7/50 (14%)   2/50 (4%)    3/50 (6%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     14/49.44     10/46.13     13/47.02     16/45.31    |7/46.24      2/46.33      3/44.26      2/40.68      | 
|POLY-3 PERCENT (g) |     28.3%        21.7%        27.7%        35.3%       |15.1%        4.3%         6.8%         4.9%         | 
|TERMINAL (d)       |     5/40 (13%)   5/39 (13%)   6/35 (17%)   7/34 (21%)  |5/37 (14%)   2/38 (5%)    2/38 (5%)    1/33 (3%)    | 
|FIRST INCIDENCE    |     416          501          616          451         |621          728 (T)      693          542          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.165      P=0.299N     P=0.572N     P=0.286     |P=0.111N     P=0.079N     P=0.163N     P=0.121N     | 
|POLY 3             |     P=0.186      P=0.306N     P=0.561N     P=0.306     |P=0.101N     P=0.078N     P=0.175N     P=0.113N     | 
|POLY 1.5           |     P=0.202      P=0.287N     P=0.536N     P=0.334     |P=0.095N     P=0.077N     P=0.168N     P=0.101N     | 
|POLY 6             |     P=0.169      P=0.319N     P=0.588      P=0.282     |P=0.107N     P=0.080N     P=0.181N     P=0.125N     | 
|LOGISTIC REGRESSION|     P=0.289      P=0.160N     P=0.463N     P=0.549     |P=0.097N     P=0.078N     P=0.172N     P=0.095N     | 
|COCH-ARM / FISHERS |     P=0.228      P=0.241N     P=0.500N     P=0.388     |P=0.080N     P=0.080N     P=0.159N     P=0.080N     | 
|=================================================================================================================================| 
       Date:  06/26/02                           EXPERIMENT: 88031 TEST: 06                                            Page 8       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 DIPROPYLENE GLYCOL              
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     29/50 (58%)  25/50 (50%)  28/50 (56%)  21/49 (43%) |17/50 (34%)  15/50 (30%)  13/50 (26%)  13/50 (26%)  | 
|POLY-3 RATE (b)    |     29/49.44     25/46.13     28/47.61     21/46.31    |17/46.49     15/46.65     13/44.12     13/41.27     | 
|POLY-3 PERCENT (g) |     58.7%        54.2%        58.8%        45.4%       |36.6%        32.2%        29.5%        31.5%        | 
|TERMINAL (d)       |     20/40 (50%)  20/39 (51%)  20/35 (57%)  10/34 (29%) |13/37 (35%)  13/38 (34%)  13/38 (34%)  11/33 (33%)  | 
|FIRST INCIDENCE    |     416          501          542          451         |621          687          728 (T)      542          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.316N     P=0.356N     P=0.443      P=0.286N    |P=0.355N     P=0.391N     P=0.241N     P=0.406N     | 
|POLY 3             |     P=0.126N     P=0.408N     P=0.576      P=0.135N    |P=0.345N     P=0.409N     P=0.310N     P=0.392N     | 
|POLY 1.5           |     P=0.116N     P=0.368N     P=0.552N     P=0.120N    |P=0.301N     P=0.404N     P=0.286N     P=0.346N     | 
|POLY 6             |     P=0.137N     P=0.437N     P=0.532      P=0.148N    |P=0.387N     P=0.419N     P=0.335N     P=0.438N     | 
|LOGISTIC REGRESSION|     P=0.102N     P=0.284N     P=0.489N     P=0.059N    |P=0.408N     P=0.402N     P=0.306N     P=0.410N     | 
|COCH-ARM / FISHERS |     P=0.104N     P=0.274N     P=0.500N     P=0.096N    |P=0.215N     P=0.415N     P=0.257N     P=0.257N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma, Hepatocellular Adenoma,                                                                           | 
|     or Hepatoblastoma                                                                                                           | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     29/50 (58%)  25/50 (50%)  28/50 (56%)  21/49 (43%) |17/50 (34%)  15/50 (30%)  14/50 (28%)  13/50 (26%)  | 
|POLY-3 RATE (b)    |     29/49.44     25/46.13     28/47.61     21/46.31    |17/46.49     15/46.65     14/44.26     13/41.27     | 
|POLY-3 PERCENT (g) |     58.7%        54.2%        58.8%        45.4%       |36.6%        32.2%        31.6%        31.5%        | 
|TERMINAL (d)       |     20/40 (50%)  20/39 (51%)  20/35 (57%)  10/34 (29%) |13/37 (35%)  13/38 (34%)  13/38 (34%)  11/33 (33%)  | 
|FIRST INCIDENCE    |     416          501          542          451         |621          687          693          542          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.316N     P=0.356N     P=0.443      P=0.286N    |P=0.371N     P=0.391N     P=0.319N     P=0.406N     | 
|POLY 3             |     P=0.126N     P=0.408N     P=0.576      P=0.135N    |P=0.360N     P=0.409N     P=0.392N     P=0.392N     | 
|POLY 1.5           |     P=0.116N     P=0.368N     P=0.552N     P=0.120N    |P=0.315N     P=0.404N     P=0.366N     P=0.346N     | 
|POLY 6             |     P=0.137N     P=0.437N     P=0.532      P=0.148N    |P=0.403N     P=0.419N     P=0.416N     P=0.438N     | 
|LOGISTIC REGRESSION|     P=0.102N     P=0.284N     P=0.489N     P=0.059N    |P=0.420N     P=0.402N     P=0.392N     P=0.410N     | 
|COCH-ARM / FISHERS |     P=0.104N     P=0.274N     P=0.500N     P=0.096N    |P=0.224N     P=0.415N     P=0.333N     P=0.257N     | 
|=================================================================================================================================| 
       Date:  06/26/02                           EXPERIMENT: 88031 TEST: 06                                            Page 9       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 DIPROPYLENE GLYCOL              
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Adenoma                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    9/50 (18%)   5/50 (10%)   4/49 (8%)   |2/50 (4%)    0/50 (0%)    4/49 (8%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     3/46.30      9/44.10      5/46.15      4/41.99     |2/45.83      0/46.33      4/44.07      1/40.09      | 
|POLY-3 PERCENT (g) |     6.5%         20.4%        10.8%        9.5%        |4.4%         0.0%         9.1%         2.5%         | 
|TERMINAL (d)       |     2/40 (5%)    9/39 (23%)   2/35 (6%)    4/34 (12%)  |2/37 (5%)    0/38 (0%)    3/38 (8%)    1/33 (3%)    | 
|FIRST INCIDENCE    |     629          729 (T)      542          729 (T)     |728 (T)      ---          576          728 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.557      P=0.056      P=0.322      P=0.417     |P=0.577      P=0.232N     P=0.345      P=0.540N     | 
|POLY 3             |     P=0.526N     P=0.048 *    P=0.355      P=0.447     |P=0.543      P=0.235N     P=0.319      P=0.546N     | 
|POLY 1.5           |     P=0.504N     P=0.051      P=0.357      P=0.463     |P=0.569      P=0.235N     P=0.323      P=0.531N     | 
|POLY 6             |     P=0.551N     P=0.047 *    P=0.348      P=0.431     |P=0.520      P=0.235N     P=0.319      P=0.560N     | 
|LOGISTIC REGRESSION|     P=0.503N     P=0.052      P=0.359      P=0.448     |P=0.588      (e)          P=0.322      P=0.540N     | 
|COCH-ARM / FISHERS |     P=0.468N     P=0.061      P=0.357      P=0.489     |P=0.578N     P=0.247N     P=0.329      P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Carcinoma                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    5/50 (10%)   8/50 (16%)   4/49 (8%)   |2/50 (4%)    2/50 (4%)    2/49 (4%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     3/45.94      5/44.35      8/46.56      4/41.99     |2/45.83      2/46.33      2/43.84      2/40.09      | 
|POLY-3 PERCENT (g) |     6.5%         11.3%        17.2%        9.5%        |4.4%         4.3%         4.6%         5.0%         | 
|TERMINAL (d)       |     3/40 (8%)    4/39 (10%)   5/35 (14%)   4/34 (12%)  |2/37 (5%)    2/38 (5%)    1/38 (3%)    2/33 (6%)    | 
|FIRST INCIDENCE    |     729 (T)      661          494          729 (T)     |728 (T)      728 (T)      654          728 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.332      P=0.344      P=0.076      P=0.411     |P=0.544      P=0.686N     P=0.688N     P=0.654      | 
|POLY 3             |     P=0.366      P=0.337      P=0.102      P=0.451     |P=0.529      P=0.690N     P=0.678      P=0.645      | 
|POLY 1.5           |     P=0.388      P=0.341      P=0.102      P=0.465     |P=0.550      P=0.689N     P=0.681      P=0.661      | 
|POLY 6             |     P=0.343      P=0.339      P=0.100      P=0.438     |P=0.512      P=0.691N     P=0.678      P=0.630      | 
|LOGISTIC REGRESSION|     P=0.404      P=0.333      P=0.102      P=0.411     |P=0.524      P=0.686N     P=0.681      P=0.654      | 
|COCH-ARM / FISHERS |     P=0.422      P=0.357      P=0.100      P=0.489     |P=0.595      P=0.691N     P=0.684      P=0.691N     | 
|=================================================================================================================================| 
       Date:  06/26/02                           EXPERIMENT: 88031 TEST: 06                                            Page 10      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 DIPROPYLENE GLYCOL              
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar                                                                      | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   14/50 (28%)  13/50 (26%)  8/49 (16%)  |3/50 (6%)    2/50 (4%)    6/49 (12%)   3/50 (6%)    | 
|POLY-3 RATE (b)    |     6/46.30      14/44.35     13/47.56     8/41.99     |3/45.83      2/46.33      6/44.34      3/40.09      | 
|POLY-3 PERCENT (g) |     13.0%        31.6%        27.3%        19.1%       |6.6%         4.3%         13.5%        7.5%         | 
|TERMINAL (d)       |     5/40 (13%)   13/39 (33%)  7/35 (20%)   8/34 (24%)  |3/37 (8%)    2/38 (5%)    4/38 (11%)   3/33 (9%)    | 
|FIRST INCIDENCE    |     629          661          494          729 (T)     |728 (T)      728 (T)      576          728 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.370      P=0.035 *    P=0.048 *    P=0.270     |P=0.386      P=0.488N     P=0.252      P=0.610      | 
|POLY 3             |     P=0.422      P=0.028 *    P=0.068      P=0.312     |P=0.359      P=0.495N     P=0.226      P=0.599      | 
|POLY 1.5           |     P=0.458      P=0.030 *    P=0.066      P=0.334     |P=0.390      P=0.495N     P=0.228      P=0.620      | 
|POLY 6             |     P=0.384      P=0.027 *    P=0.068      P=0.291     |P=0.333      P=0.496N     P=0.228      P=0.580      | 
|LOGISTIC REGRESSION|     P=0.474      P=0.030 *    P=0.064      P=0.297     |P=0.381      P=0.488N     P=0.227      P=0.610      | 
|COCH-ARM / FISHERS |     P=0.514      P=0.039 *    P=0.062      P=0.371     |P=0.461      P=0.500N     P=0.233      P=0.661N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)   |2/50 (4%)    1/50 (2%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/45.94      0/44.10      0/45.14      0/41.99     |2/45.84      1/46.33      0/44.12      1/40.09      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |4.4%         2.2%         0.0%         2.5%         | 
|TERMINAL (d)       |     0/40 (0%)    0/39 (0%)    0/35 (0%)    0/34 (0%)   |1/37 (3%)    1/38 (3%)    0/38 (0%)    1/33 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |725          728 (T)      ---          728 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.400N     P=0.491N     P=0.237N     P=0.543N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.378N     P=0.496N     P=0.246N     P=0.546N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.375N     P=0.496N     P=0.242N     P=0.531N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.380N     P=0.497N     P=0.248N     P=0.560N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.413N     P=0.496N     P=0.244N     P=0.560N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.366N     P=0.500N     P=0.247N     P=0.500N     | 
|=================================================================================================================================| 
       Date:  06/26/02                           EXPERIMENT: 88031 TEST: 06                                            Page 11      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 DIPROPYLENE GLYCOL              
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)   |2/50 (4%)    1/50 (2%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/45.94      0/44.10      0/45.14      0/41.99     |2/45.84      1/46.33      0/44.12      1/40.09      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |4.4%         2.2%         0.0%         2.5%         | 
|TERMINAL (d)       |     0/40 (0%)    0/39 (0%)    0/35 (0%)    0/34 (0%)   |1/37 (3%)    1/38 (3%)    0/38 (0%)    1/33 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |725          728 (T)      ---          728 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.400N     P=0.491N     P=0.237N     P=0.543N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.378N     P=0.496N     P=0.246N     P=0.546N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.375N     P=0.496N     P=0.242N     P=0.531N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.380N     P=0.497N     P=0.248N     P=0.560N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.413N     P=0.496N     P=0.244N     P=0.560N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.366N     P=0.500N     P=0.247N     P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery                                                                                                                        | 
|     Sarcoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)   |0/50 (0%)    2/50 (4%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/45.94      0/44.10      0/45.14      0/41.99     |0/45.83      2/46.78      1/44.56      0/40.09      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         4.3%         2.2%         0.0%         | 
|TERMINAL (d)       |     0/40 (0%)    0/39 (0%)    0/35 (0%)    0/34 (0%)   |0/37 (0%)    0/38 (0%)    0/38 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          643          599          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.515N     P=0.240      P=0.482      (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.505N     P=0.242      P=0.494      (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.490N     P=0.241      P=0.497      (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.517N     P=0.243      P=0.494      (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.408N     P=0.216      P=0.500      (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.461N     P=0.247      P=0.500      (e)          | 
|=================================================================================================================================| 
       Date:  06/26/02                           EXPERIMENT: 88031 TEST: 06                                            Page 12      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 DIPROPYLENE GLYCOL              
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cystadenoma                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |0/50 (0%)    2/50 (4%)    2/50 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |                                                        |0/45.83      2/46.33      2/44.12      1/40.09      | 
|POLY-3 PERCENT (g) |                                                        |0.0%         4.3%         4.5%         2.5%         | 
|TERMINAL (d)       |                                                        |0/37 (0%)    2/38 (5%)    2/38 (5%)    1/33 (3%)    | 
|FIRST INCIDENCE    |                                                        |---          728 (T)      728 (T)      728 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.428      P=0.244      P=0.244      P=0.477      | 
|POLY 3             |                                                        |P=0.395      P=0.240      P=0.229      P=0.473      | 
|POLY 1.5           |                                                        |P=0.419      P=0.240      P=0.232      P=0.482      | 
|POLY 6             |                                                        |P=0.374      P=0.239      P=0.226      P=0.466      | 
|LOGISTIC REGRESSION|                                                        |(e)          P=0.244      P=0.244      P=0.477      | 
|COCH-ARM / FISHERS |                                                        |P=0.469      P=0.247      P=0.247      P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/48 (0%)    0/49 (0%)    0/49 (0%)   |1/49 (2%)    3/49 (6%)    3/49 (6%)    3/49 (6%)    | 
|POLY-3 RATE (b)    |     0/45.41      0/42.52      0/44.14      0/41.99     |1/45.81      3/45.47      3/43.56      3/39.37      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |2.2%         6.6%         6.9%         7.6%         | 
|TERMINAL (d)       |     0/40 (0%)    0/39 (0%)    0/34 (0%)    0/34 (0%)   |1/37 (3%)    3/38 (8%)    3/38 (8%)    2/32 (6%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |728 (T)      728 (T)      728 (T)      654          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.226      P=0.314      P=0.314      P=0.254      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.218      P=0.303      P=0.287      P=0.253      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.238      P=0.304      P=0.293      P=0.268      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.203      P=0.302      P=0.285      P=0.242      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.206      P=0.314      P=0.314      P=0.249      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.292      P=0.309      P=0.309      P=0.309      | 
|=================================================================================================================================| 
       Date:  06/26/02                           EXPERIMENT: 88031 TEST: 06                                            Page 13      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 DIPROPYLENE GLYCOL              
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skeletal Muscle                                                                                                                  | 
|     Sarcoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/50 (2%)    0/49 (0%)   |2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/45.94      0/44.10      1/45.83      0/41.99     |2/46.15      0/46.33      0/44.12      0/40.09      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.2%         0.0%        |4.3%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/40 (0%)    0/39 (0%)    0/35 (0%)    0/34 (0%)   |1/37 (3%)    0/38 (0%)    0/38 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          494          ---         |641          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.688      (e)          P=0.504      (e)         |P=0.127N     P=0.234N     P=0.244N     P=0.274N     | 
|POLY 3             |     P=0.665      (e)          P=0.500      (e)         |P=0.110N     P=0.236N     P=0.247N     P=0.270N     | 
|POLY 1.5           |     P=0.675      (e)          P=0.500      (e)         |P=0.112N     P=0.235N     P=0.243N     P=0.259N     | 
|POLY 6             |     P=0.654      (e)          P=0.497      (e)         |P=0.108N     P=0.238N     P=0.251N     P=0.281N     | 
|LOGISTIC REGRESSION|     P=0.706      (e)          P=0.358      (e)         |P=0.110N     P=0.244N     P=0.235N     P=0.241N     | 
|COCH-ARM / FISHERS |     P=0.692      (e)          P=0.500      (e)         |P=0.115N     P=0.247N     P=0.247N     P=0.247N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Sarcoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)   |3/50 (6%)    7/50 (14%)   2/50 (4%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     0/45.94      0/44.10      0/45.14      0/41.99     |3/46.67      7/47.51      2/44.90      3/40.63      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |6.4%         14.7%        4.5%         7.4%         | 
|TERMINAL (d)       |     0/40 (0%)    0/39 (0%)    0/35 (0%)    0/34 (0%)   |1/37 (3%)    2/38 (5%)    0/38 (0%)    2/33 (6%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |570          561          576          565          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.444N     P=0.177      P=0.516N     P=0.579      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.417N     P=0.165      P=0.518N     P=0.597      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.392N     P=0.164      P=0.510N     P=0.619      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.440N     P=0.166      P=0.522N     P=0.576      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.277N     P=0.129      P=0.484N     P=0.644N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.341N     P=0.159      P=0.500N     P=0.661N     | 
|=================================================================================================================================| 
       Date:  06/26/02                           EXPERIMENT: 88031 TEST: 06                                            Page 14      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 DIPROPYLENE GLYCOL              
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Squamous Cell Carcinoma or Papilloma Squamous                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    0/49 (0%)   |2/50 (4%)    1/50 (2%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/45.94      0/44.10      0/45.14      0/41.99     |2/45.83      1/46.40      0/44.12      1/40.09      | 
|POLY-3 PERCENT (g) |     2.2%         0.0%         0.0%         0.0%        |4.4%         2.2%         0.0%         2.5%         | 
|TERMINAL (d)       |     1/40 (3%)    0/39 (0%)    0/35 (0%)    0/34 (0%)   |2/37 (5%)    0/38 (0%)    0/38 (0%)    1/33 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          ---         |728 (T)      711          ---          728 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.327N     P=0.505N     P=0.527N     P=0.532N    |P=0.402N     P=0.491N     P=0.232N     P=0.540N     | 
|POLY 3             |     P=0.298N     P=0.508N     P=0.504N     P=0.518N    |P=0.378N     P=0.496N     P=0.246N     P=0.546N     | 
|POLY 1.5           |     P=0.301N     P=0.506N     P=0.502N     P=0.513N    |P=0.375N     P=0.496N     P=0.242N     P=0.531N     | 
|POLY 6             |     P=0.296N     P=0.508N     P=0.507N     P=0.523N    |P=0.380N     P=0.496N     P=0.248N     P=0.560N     | 
|LOGISTIC REGRESSION|     P=0.327N     (e)          (e)          (e)         |P=0.418N     P=0.497N     (e)          P=0.540N     | 
|COCH-ARM / FISHERS |     P=0.308N     P=0.500N     P=0.500N     P=0.505N    |P=0.366N     P=0.500N     P=0.247N     P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Squamous Cell Papilloma                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)   |2/50 (4%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/45.94      0/44.10      0/45.14      0/41.99     |2/45.83      0/46.33      0/44.12      1/40.09      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |4.4%         0.0%         0.0%         2.5%         | 
|TERMINAL (d)       |     0/40 (0%)    0/39 (0%)    0/35 (0%)    0/34 (0%)   |2/37 (5%)    0/38 (0%)    0/38 (0%)    1/33 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |728 (T)      ---          ---          728 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.491N     P=0.232N     P=0.232N     P=0.540N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.460N     P=0.235N     P=0.246N     P=0.546N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.461N     P=0.235N     P=0.242N     P=0.531N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.457N     P=0.235N     P=0.248N     P=0.560N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.491N     (e)          (e)          P=0.540N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.461N     P=0.247N     P=0.247N     P=0.500N     | 
|=================================================================================================================================| 
       Date:  06/26/02                           EXPERIMENT: 88031 TEST: 06                                            Page 15      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 DIPROPYLENE GLYCOL              
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes                                                                                                                           | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    0/50 (0%)    0/50 (0%)    1/49 (2%)   |                                                    | 
|POLY-3 RATE (b)    |     3/46.03      0/44.10      0/45.14      1/41.99     |                                                    | 
|POLY-3 PERCENT (g) |     6.5%         0.0%         0.0%         2.4%        |                                                    | 
|TERMINAL (d)       |     2/40 (5%)    0/39 (0%)    0/35 (0%)    1/34 (3%)   |                                                    | 
|FIRST INCIDENCE    |     708          ---          ---          729 (T)     |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.288N     P=0.129N     P=0.147N     P=0.365N    |                                                    | 
|POLY 3             |     P=0.243N     P=0.127N     P=0.122N     P=0.339N    |                                                    | 
|POLY 1.5           |     P=0.245N     P=0.125N     P=0.120N     P=0.329N    |                                                    | 
|POLY 6             |     P=0.244N     P=0.127N     P=0.126N     P=0.348N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.274N     P=0.127N     P=0.128N     P=0.350N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.251N     P=0.121N     P=0.121N     P=0.316N    |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Hemangioma                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    2/50 (4%)    0/49 (0%)   |2/50 (4%)    0/50 (0%)    2/50 (4%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     2/45.94      1/44.10      2/45.14      0/41.99     |2/45.83      0/46.33      2/44.12      2/40.76      | 
|POLY-3 PERCENT (g) |     4.4%         2.3%         4.4%         0.0%        |4.4%         0.0%         4.5%         4.9%         | 
|TERMINAL (d)       |     2/40 (5%)    1/39 (3%)    2/35 (6%)    0/34 (0%)   |2/37 (5%)    0/38 (0%)    2/38 (5%)    1/33 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      ---         |728 (T)      ---          728 (T)      504          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.240N     P=0.509N     P=0.646      P=0.275N    |P=0.401      P=0.232N     P=0.686N     P=0.654      | 
|POLY 3             |     P=0.218N     P=0.514N     P=0.688      P=0.258N    |P=0.396      P=0.235N     P=0.680      P=0.651      | 
|POLY 1.5           |     P=0.212N     P=0.511N     P=0.691      P=0.252N    |P=0.410      P=0.235N     P=0.686      P=0.665      | 
|POLY 6             |     P=0.225N     P=0.515N     P=0.681      P=0.263N    |P=0.385      P=0.235N     P=0.677      P=0.639      | 
|LOGISTIC REGRESSION|     P=0.240N     P=0.509N     P=0.646      (e)         |P=0.434      (e)          P=0.686N     P=0.695N     | 
|COCH-ARM / FISHERS |     P=0.204N     P=0.500N     P=0.691N     P=0.253N    |P=0.444      P=0.247N     P=0.691N     P=0.691N     | 
|=================================================================================================================================| 
       Date:  06/26/02                           EXPERIMENT: 88031 TEST: 06                                            Page 16      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 DIPROPYLENE GLYCOL              
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    4/50 (8%)    2/50 (4%)    3/49 (6%)   |3/50 (6%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/45.94      4/44.10      2/45.15      3/42.41     |3/46.21      1/46.33      0/44.12      0/40.09      | 
|POLY-3 PERCENT (g) |     0.0%         9.1%         4.4%         7.1%        |6.5%         2.2%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/40 (0%)    4/39 (10%)   1/35 (3%)    2/34 (6%)   |2/37 (5%)    1/38 (3%)    0/38 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      727          610         |621          728 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.175      P=0.060      P=0.214      P=0.101     |P=0.051N     P=0.300N     P=0.125N     P=0.151N     | 
|POLY 3             |     P=0.193      P=0.055      P=0.233      P=0.105     |P=0.046N*    P=0.304N     P=0.127N     P=0.146N     | 
|POLY 1.5           |     P=0.202      P=0.056      P=0.236      P=0.108     |P=0.045N*    P=0.303N     P=0.124N     P=0.137N     | 
|POLY 6             |     P=0.185      P=0.055      P=0.229      P=0.102     |P=0.046N*    P=0.307N     P=0.130N     P=0.156N     | 
|LOGISTIC REGRESSION|     P=0.195      P=0.060      P=0.214      P=0.116     |P=0.046N*    P=0.305N     P=0.120N     P=0.128N     | 
|COCH-ARM / FISHERS |     P=0.219      P=0.059      P=0.247      P=0.117     |P=0.044N*    P=0.309N     P=0.121N     P=0.121N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Hemangiosarcoma or Hemangioma                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    5/50 (10%)   4/50 (8%)    3/49 (6%)   |5/50 (10%)   1/50 (2%)    2/50 (4%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     2/45.94      5/44.10      4/45.15      3/42.41     |5/46.21      1/46.33      2/44.12      2/40.76      | 
|POLY-3 PERCENT (g) |     4.4%         11.3%        8.9%         7.1%        |10.8%        2.2%         4.5%         4.9%         | 
|TERMINAL (d)       |     2/40 (5%)    5/39 (13%)   3/35 (9%)    2/34 (6%)   |4/37 (11%)   1/38 (3%)    2/38 (5%)    1/33 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      727          610         |621          728 (T)      728 (T)      504          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.443      P=0.206      P=0.281      P=0.435     |P=0.266N     P=0.100N     P=0.214N     P=0.273N     | 
|POLY 3             |     P=0.486      P=0.200      P=0.329      P=0.464     |P=0.253N     P=0.101N     P=0.235N     P=0.270N     | 
|POLY 1.5           |     P=0.500      P=0.203      P=0.334      P=0.473     |P=0.243N     P=0.100N     P=0.227N     P=0.252N     | 
|POLY 6             |     P=0.472      P=0.199      P=0.320      P=0.456     |P=0.260N     P=0.102N     P=0.242N     P=0.287N     | 
|LOGISTIC REGRESSION|     P=0.476      P=0.206      P=0.282      P=0.471     |P=0.233N     P=0.101N     P=0.230N     P=0.220N     | 
|COCH-ARM / FISHERS |     P=0.526      P=0.218      P=0.339      P=0.490     |P=0.221N     P=0.102N     P=0.218N     P=0.218N     | 
|=================================================================================================================================| 
       Date:  06/26/02                           EXPERIMENT: 88031 TEST: 06                                            Page 17      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 DIPROPYLENE GLYCOL              
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,                                                                        | 
|     NOS, or Undifferentiated Cell Type                                                                                          | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    0/49 (0%)   |5/50 (10%)   2/50 (4%)    2/50 (4%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |     1/45.94      0/44.10      0/45.14      0/41.99     |5/46.82      2/46.55      2/44.20      4/40.21      | 
|POLY-3 PERCENT (g) |     2.2%         0.0%         0.0%         0.0%        |10.7%        4.3%         4.5%         10.0%        | 
|TERMINAL (d)       |     1/40 (3%)    0/39 (0%)    0/35 (0%)    0/34 (0%)   |3/37 (8%)    1/38 (3%)    1/38 (3%)    3/33 (9%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          ---         |193          671          708          698          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.327N     P=0.505N     P=0.527N     P=0.532N    |P=0.564      P=0.213N     P=0.216N     P=0.570N     | 
|POLY 3             |     P=0.298N     P=0.508N     P=0.504N     P=0.518N    |P=0.568      P=0.219N     P=0.240N     P=0.594N     | 
|POLY 1.5           |     P=0.301N     P=0.506N     P=0.502N     P=0.513N    |P=0.558N     P=0.218N     P=0.233N     P=0.566N     | 
|POLY 6             |     P=0.296N     P=0.508N     P=0.507N     P=0.523N    |P=0.553      P=0.218N     P=0.244N     P=0.617N     | 
|LOGISTIC REGRESSION|     P=0.327N     (e)          (e)          (e)         |P=0.497N     P=0.267N     P=0.200N     P=0.479N     | 
|COCH-ARM / FISHERS |     P=0.308N     P=0.500N     P=0.500N     P=0.505N    |P=0.519N     P=0.218N     P=0.218N     P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Benign Tumors                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     27/50 (54%)  23/50 (46%)  26/50 (52%)  11/49 (22%) |22/50 (44%)  24/50 (48%)  22/50 (44%)  21/50 (42%)  | 
|POLY-3 RATE (b)    |     27/46.85     23/44.17     26/46.67     11/42.99    |22/46.09     24/46.96     22/44.76     21/43.05     | 
|POLY-3 PERCENT (g) |     57.6%        52.1%        55.7%        25.6%       |47.7%        51.1%        49.2%        48.8%        | 
|TERMINAL (d)       |     24/40 (60%)  22/39 (56%)  21/35 (60%)  9/34 (27%)  |19/37 (51%)  21/38 (55%)  20/38 (53%)  16/33 (49%)  | 
|FIRST INCIDENCE    |     592          710          542          464         |693          641          576          395          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.008N**   P=0.316N     P=0.415      P=0.006N**  |P=0.446      P=0.464      P=0.547N     P=0.458      | 
|POLY 3             |     P<0.001N**   P=0.372N     P=0.509N     P<0.001N**  |P=0.534      P=0.453      P=0.530      P=0.545      | 
|POLY 1.5           |     P<0.001N**   P=0.342N     P=0.501N     P<0.001N**  |P=0.504N     P=0.448      P=0.551      P=0.576      | 
|POLY 6             |     P=0.002N**   P=0.396N     P=0.531N     P=0.002N**  |P=0.504      P=0.458      P=0.518      P=0.522      | 
|LOGISTIC REGRESSION|     P=0.002N**   P=0.337N     P=0.541N     P=0.002N**  |P=0.410      P=0.431      P=0.488      P=0.484      | 
|COCH-ARM / FISHERS |     P<0.001N**   P=0.274N     P=0.500N     P<0.001N**  |P=0.396N     P=0.421      P=0.580N     P=0.500N     | 
|=================================================================================================================================| 
       Date:  06/26/02                           EXPERIMENT: 88031 TEST: 06                                            Page 18      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 DIPROPYLENE GLYCOL              
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant Tumors                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     19/50 (38%)  19/50 (38%)  26/50 (52%)  25/49 (51%) |18/50 (36%)  18/50 (36%)  14/50 (28%)  14/50 (28%)  | 
|POLY-3 RATE (b)    |     19/49.44     19/46.96     26/48.45     25/46.47    |18/48.75     18/48.25     14/46.34     14/42.33     | 
|POLY-3 PERCENT (g) |     38.4%        40.5%        53.7%        53.8%       |36.9%        37.3%        30.2%        33.1%        | 
|TERMINAL (d)       |     10/40 (25%)  13/39 (33%)  15/35 (43%)  14/34 (41%) |11/37 (30%)  9/38 (24%)   7/38 (18%)   9/33 (27%)   | 
|FIRST INCIDENCE    |     416          405          494          451         |193          561          576          395          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.043 *    P=0.525      P=0.095      P=0.091     |P=0.359N     P=0.546N     P=0.287N     P=0.426N     | 
|POLY 3             |     P=0.050      P=0.502      P=0.094      P=0.095     |P=0.331N     P=0.567      P=0.318N     P=0.435N     | 
|POLY 1.5           |     P=0.056      P=0.523      P=0.102      P=0.107     |P=0.282N     P=0.571      P=0.302N     P=0.380N     | 
|POLY 6             |     P=0.044 *    P=0.486      P=0.083      P=0.086     |P=0.375N     P=0.574      P=0.319N     P=0.485N     | 
|LOGISTIC REGRESSION|     P=0.092      P=0.513N     P=0.128      P=0.210     |P=0.147N     P=0.554      P=0.224N     P=0.234N     | 
|COCH-ARM / FISHERS |     P=0.070      P=0.582N     P=0.114      P=0.135     |P=0.178N     P=0.582N     P=0.260N     P=0.260N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         1.0%         2.0%         4.0%        |0.0%         1.0%         2.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant and Benign Tumors                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     39/50 (78%)  37/50 (74%)  39/50 (78%)  33/49 (67%) |32/50 (64%)  35/50 (70%)  30/50 (60%)  29/50 (58%)  | 
|POLY-3 RATE (b)    |     39/49.44     37/47.03     39/49.03     33/46.72    |32/49.00     35/48.25     30/46.34     29/44.45     | 
|POLY-3 PERCENT (g) |     78.9%        78.7%        79.5%        70.6%       |65.3%        72.5%        64.7%        65.2%        | 
|TERMINAL (d)       |     30/40 (75%)  30/39 (77%)  27/35 (77%)  21/34 (62%) |23/37 (62%)  26/38 (68%)  23/38 (61%)  20/33 (61%)  | 
|FIRST INCIDENCE    |     416          405          494          451         |193          561          576          395          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.521      P=0.509N     P=0.300      P=0.517N    |P=0.527N     P=0.414      P=0.413N     P=0.513      | 
|POLY 3             |     P=0.187N     P=0.589N     P=0.567      P=0.242N    |P=0.435N     P=0.289      P=0.563N     P=0.584N     | 
|POLY 1.5           |     P=0.173N     P=0.540N     P=0.581      P=0.216N    |P=0.368N     P=0.304      P=0.520N     P=0.521N     | 
|POLY 6             |     P=0.197N     P=0.578      P=0.539      P=0.258N    |P=0.485N     P=0.284      P=0.579N     P=0.546      | 
|LOGISTIC REGRESSION|     P=0.174N     P=0.471N     P=0.587N     P=0.168N    |P=0.333N     P=0.335      P=0.435N     P=0.416N     | 
|COCH-ARM / FISHERS |     P=0.152N     P=0.408N     P=0.595N     P=0.168N    |P=0.200N     P=0.335      P=0.418N     P=0.341N     | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).