TDMS Study 88034-04 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
OZONE
NTP Experiment-Test: 88034-04 Report: PEIRPT03
Study Type: CHRONIC Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:38:29
Facility: Battelle Northwest
Chemical CAS #: 10028-15-6
Lock Date: 02/17/93
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 88034-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:38:29
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 15 10 9 9
Natural Death 6 3 6 1
Accidently Killed 2
Survivors
Terminal Sacrifice 29 37 33 40
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (50) (47) (46) (50)
Inflammation, Chronic Active 1 (2%)
Intestine Small, Duodenum (47) (48) (45) (49)
Inflammation, Acute 1 (2%)
Necrosis 1 (2%)
Intestine Small, Jejunum (50) (47) (46) (49)
Hyperplasia, Lymphoid 1 (2%)
Inflammation, Chronic Active 1 (2%)
Liver (50) (50) (50) (50)
Angiectasis 1 (2%) 1 (2%) 1 (2%)
Basophilic Focus 1 (2%) 2 (4%) 2 (4%)
Clear Cell Focus 1 (2%) 1 (2%) 2 (4%)
Cyst 1 (2%)
Degeneration, Fatty 1 (2%) 1 (2%)
Eosinophilic Focus 3 (6%) 3 (6%) 5 (10%) 4 (8%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%) 1 (2%)
Hepatodiaphragmatic Nodule 1 (2%)
Necrosis 1 (2%) 2 (4%) 1 (2%)
Centrilobular, Necrosis 1 (2%)
Mesentery (11) (4) (4) (1)
Artery, Inflammation, Chronic Active 1 (9%)
Fat, Inflammation, Chronic 1 (25%)
Fat, Necrosis 7 (64%) 3 (75%) 3 (75%)
Pancreas (49) (50) (48) (50)
Atrophy 1 (2%) 2 (4%) 1 (2%)
Basophilic Focus 1 (2%)
Cyst 1 (2%)
Hypertrophy 1 (2%) 1 (2%)
Lipomatosis 1 (2%)
Artery, Inflammation, Chronic Active 1 (2%)
Salivary Glands (50) (49) (49) (50)
Degeneration, Fatty 1 (2%)
Stomach, Forestomach (50) (50) (48) (50)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 88034-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:38:29
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Diverticulum 1 (2%)
Hyperplasia, Squamous 1 (2%) 3 (6%)
Inflammation, Acute 1 (2%) 5 (10%)
Mineralization 1 (2%)
Necrosis 1 (2%)
Stomach, Glandular (50) (50) (48) (50)
Mineralization 2 (4%) 8 (16%) 6 (13%) 3 (6%)
Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Cardiomyopathy 6 (12%) 8 (16%) 5 (10%) 5 (10%)
Mineralization 1 (2%)
Artery, Inflammation, Chronic Active 1 (2%)
Atrium, Thrombosis 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (49) (50)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia 1 (2%) 4 (8%) 7 (14%) 3 (6%)
Hypertrophy 1 (2%) 4 (8%)
Vacuolization Cytoplasmic 1 (2%) 1 (2%)
Adrenal Medulla (50) (50) (49) (50)
Hyperplasia 1 (2%) 1 (2%) 2 (4%) 2 (4%)
Islets, Pancreatic (49) (50) (48) (50)
Hyperplasia 1 (2%) 1 (2%)
Pituitary Gland (50) (50) (47) (49)
Cyst 1 (2%)
Pars Distalis, Hyperplasia 11 (22%) 14 (28%) 20 (43%) 17 (35%)
Pars Intermedia, Hyperplasia 1 (2%) 1 (2%) 2 (4%) 1 (2%)
Thyroid Gland (50) (50) (49) (50)
Follicular Cell, Hyperplasia 8 (16%) 19 (38%) 21 (43%) 25 (50%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 88034-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:38:29
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (50) (50) (48) (50)
Angiectasis 2 (4%) 2 (4%)
Cyst 11 (22%) 12 (24%) 13 (27%) 11 (22%)
Hyperplasia, Tubular 1 (2%)
Inflammation, Suppurative 1 (2%)
Thrombosis 1 (2%) 1 (2%)
Uterus (50) (50) (49) (50)
Angiectasis 1 (2%) 2 (4%) 1 (2%) 2 (4%)
Decidual Reaction 1 (2%)
Hydrometra 4 (8%) 8 (16%) 3 (6%) 3 (6%)
Inflammation, Suppurative 1 (2%) 1 (2%)
Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (49) (50)
Myelofibrosis 1 (2%)
Lymph Node (9) (6) (3) (4)
Iliac, Angiectasis 1 (11%)
Iliac, Hematopoietic Cell Proliferation 1 (11%)
Iliac, Hemorrhage 1 (11%)
Iliac, Infiltration Cellular, Plasma Cell 1 (33%)
Iliac, Infiltration Cellular, Histiocyte 1 (11%)
Lumbar, Infiltration Cellular, Histiocyte 1 (11%)
Renal, Hematopoietic Cell Proliferation 1 (11%)
Lymph Node, Bronchial (48) (39) (40) (42)
Infiltration Cellular, Plasma Cell 1 (3%)
Lymph Node, Mandibular (47) (39) (43) (46)
Hematopoietic Cell Proliferation 1 (2%)
Infiltration Cellular, Histiocyte 1 (2%)
Lymph Node, Mesenteric (49) (49) (46) (47)
Angiectasis 1 (2%) 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Hemorrhage 2 (4%) 1 (2%)
Inflammation, Chronic Active 2 (4%)
Lymph Node, Mediastinal (41) (42) (39) (35)
Infiltration Cellular, Plasma Cell 1 (2%)
Spleen (49) (50) (48) (50)
Hematopoietic Cell Proliferation 11 (22%) 6 (12%) 10 (21%) 3 (6%)
Hyperplasia, Lymphoid 2 (4%) 2 (4%) 2 (4%)
Hyperplasia, Mast Cell 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 88034-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:38:29
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (48) (49)
Hyperplasia 1 (2%)
Skin (50) (50) (49) (50)
Prepuce, Inflammation, Chronic Active 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (49) (50)
Necrosis 1 (2%)
Meninges, Inflammation, Chronic 1 (2%) 1 (2%) 1 (2%)
Spinal Cord (1)
Inflammation, Chronic 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (50) (49) (50)
Inflammation, Chronic Active 2 (4%) 1 (2%)
Epiglottis, Hyperplasia 7 (14%)
Epiglottis, Metaplasia, Squamous 4 (8%)
Lung (50) (50) (49) (50)
Congestion, Chronic 1 (2%) 1 (2%)
Thrombosis 1 (2%)
Alveolar Epithelium, Hyperplasia 2 (4%) 1 (2%) 1 (2%) 2 (4%)
Alveolar Epithelium, Metaplasia 43 (88%) 49 (98%)
Alveolus, Infiltration Cellular, Histiocyte 11 (22%) 42 (84%)
Bronchiole, Hyperplasia 2 (4%)
Bronchiole, Necrosis 1 (2%)
Nose (50) (50) (48) (50)
Glands, Hyperplasia 1 (2%)
Lateral Wall, Degeneration, Hyaline 5 (10%) 18 (36%) 48 (100%) 50 (100%)
Lateral Wall, Fibrosis 3 (6%) 46 (96%) 50 (100%)
Lateral Wall, Hyperplasia 42 (88%) 50 (100%)
Lateral Wall, Inflammation, Suppurative 5 (10%) 46 (96%) 50 (100%)
Lateral Wall, Metaplasia, Squamous 1 (2%) 1 (2%) 11 (23%) 36 (72%)
Olfactory Epithelium, Atrophy 4 (8%) 1 (2%) 14 (29%) 41 (82%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 88034-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:38:29
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2)
Inflammation, Chronic Active 1 (50%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (49) (50)
Amyloid Deposition 1 (2%)
Infarct 1 (2%) 1 (2%) 1 (2%)
Nephropathy 25 (50%) 33 (66%) 29 (59%) 26 (52%)
Renal Tubule, Necrosis 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 88034-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:38:29
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 16 10 19 20
Natural Death 4 6 6 3
Survivors
Terminal Sacrifice 29 34 25 27
Natural Death 1
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (46) (46) (48) (48)
Degeneration, Hyaline 1 (2%)
Intestine Small, Duodenum (49) (47) (48) (48)
Necrosis 1 (2%)
Intestine Small, Ileum (49) (48) (49) (50)
Inflammation, Chronic Active 1 (2%)
Peyer's Patch, Infiltration Cellular, Plasma
Cell 1 (2%)
Liver (50) (50) (50) (50)
Angiectasis 1 (2%)
Basophilic Focus 2 (4%)
Clear Cell Focus 4 (8%) 4 (8%) 2 (4%) 1 (2%)
Cyst 1 (2%)
Degeneration, Fatty 1 (2%)
Eosinophilic Focus 1 (2%) 2 (4%) 2 (4%)
Fibrosis 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Inflammation, Chronic Active 1 (2%)
Karyomegaly 1 (2%)
Mineralization 1 (2%)
Necrosis 3 (6%) 1 (2%) 1 (2%)
Centrilobular, Necrosis 1 (2%) 2 (4%)
Mesentery (4) (5) (1) (3)
Inflammation, Chronic Active 1 (20%)
Fat, Necrosis 3 (75%) 3 (60%) 3 (100%)
Pancreas (49) (50) (50) (50)
Atrophy 1 (2%) 1 (2%)
Basophilic Focus 1 (2%)
Stomach, Forestomach (50) (50) (50) (50)
Angiectasis 1 (2%)
Hyperplasia, Squamous 1 (2%) 1 (2%)
Inflammation, Acute 3 (6%) 1 (2%)
Necrosis 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 88034-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:38:29
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Stomach, Glandular (50) (49) (50) (50)
Inflammation, Acute 1 (2%)
Tooth (1) (1) (1) (1)
Developmental Malformation 1 (100%)
Inflammation, Chronic Active 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Cardiomyopathy 8 (16%) 18 (36%) 11 (22%) 17 (34%)
Inflammation, Chronic Active 1 (2%)
Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Atrophy 1 (2%)
Hyperplasia 14 (28%) 9 (18%) 12 (24%) 15 (30%)
Hypertrophy 26 (52%) 31 (62%) 22 (44%) 22 (44%)
Capsule, Hyperplasia 3 (6%) 1 (2%) 1 (2%)
Adrenal Medulla (50) (50) (50) (50)
Hyperplasia 2 (4%) 2 (4%) 2 (4%) 3 (6%)
Pituitary Gland (47) (49) (49) (48)
Cyst 1 (2%) 1 (2%) 1 (2%)
Pars Distalis, Hyperplasia 5 (11%) 2 (4%) 1 (2%)
Thyroid Gland (49) (50) (50) (50)
Inflammation, Chronic 2 (4%)
Follicular Cell, Hyperplasia 6 (12%) 8 (16%) 10 (20%) 17 (34%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (50)
Granuloma Sperm 1 (2%) 2 (4%) 1 (2%)
Penis (2) (1)
Inflammation, Acute 1 (50%) 1 (100%)
Preputial Gland (50) (50) (50) (50)
Cyst 1 (2%)
Hyperplasia 1 (2%)
Inflammation, Chronic Active 12 (24%) 4 (8%) 6 (12%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 88034-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:38:29
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Necrosis 1 (2%)
Prostate (49) (50) (47) (49)
Inflammation, Suppurative 1 (2%) 2 (4%) 2 (4%)
Artery, Inflammation, Chronic Active 1 (2%)
Seminal Vesicle (50) (50) (50) (50)
Inflammation, Chronic Active 1 (2%) 1 (2%) 1 (2%)
Testes (50) (50) (50) (50)
Atrophy 4 (8%) 2 (4%) 1 (2%) 4 (8%)
Mineralization 1 (2%) 3 (6%)
Interstitial Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (50) (50) (50)
Atrophy 1 (2%)
Necrosis 1 (2%)
Lymph Node (4) (6) (3) (10)
Iliac, Infiltration Cellular, Plasma Cell 1 (25%) 1 (17%) 1 (33%) 7 (70%)
Inguinal, Infiltration Cellular, Plasma Cell 1 (17%)
Renal, Infiltration Cellular, Plasma Cell 1 (25%) 1 (10%)
Lymph Node, Mesenteric (48) (49) (49) (49)
Angiectasis 1 (2%) 1 (2%)
Hemorrhage 2 (4%)
Spleen (49) (50) (49) (50)
Angiectasis 1 (2%)
Hematopoietic Cell Proliferation 2 (4%) 3 (6%) 3 (6%) 6 (12%)
Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (50) (50) (50)
Ulcer 1 (2%)
Prepuce, Inflammation, Chronic Active 8 (16%) 6 (12%) 12 (24%) 20 (40%)
Subcutaneous Tissue, Fibrosis 1 (2%)
Subcutaneous Tissue, Inflammation,
Granulomatous 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 88034-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:38:29
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Hemorrhage 1 (2%)
Necrosis 1 (2%)
Meninges, Inflammation, Chronic 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (50) (50) (50)
Inflammation, Chronic 1 (2%)
Inflammation, Chronic Active 4 (8%) 13 (26%) 4 (8%) 9 (18%)
Artery, Inflammation, Chronic Active 1 (2%)
Epiglottis, Hyperplasia 1 (2%) 6 (12%)
Epiglottis, Metaplasia, Squamous 2 (4%)
Lung (50) (50) (50) (50)
Fibrosis 1 (2%)
Hemorrhage 1 (2%) 1 (2%) 1 (2%)
Thrombosis 1 (2%)
Alveolar Epithelium, Hyperplasia 4 (8%) 6 (12%) 2 (4%) 3 (6%)
Alveolar Epithelium, Metaplasia 48 (96%) 50 (100%)
Alveolus, Infiltration Cellular, Histiocyte 18 (36%) 31 (62%)
Bronchiole, Erosion 1 (2%)
Bronchiole, Hyperplasia 1 (2%)
Bronchiole, Necrosis 3 (6%)
Bronchus, Erosion 1 (2%)
Bronchus, Necrosis 1 (2%)
Nose (50) (50) (50) (50)
Inflammation, Suppurative 2 (4%)
Lateral Wall, Degeneration, Hyaline 2 (4%) 1 (2%) 49 (98%) 50 (100%)
Lateral Wall, Fibrosis 47 (94%) 49 (98%)
Lateral Wall, Hyperplasia 42 (84%) 50 (100%)
Lateral Wall, Inflammation, Suppurative 8 (16%) 42 (84%) 50 (100%)
Lateral Wall, Metaplasia, Squamous 3 (6%) 3 (6%) 36 (72%)
Nasopharyngeal Duct, Inflammation, Chronic
Active 1 (2%)
Olfactory Epithelium, Atrophy 1 (2%) 3 (6%) 3 (6%) 11 (22%)
Olfactory Epithelium, Metaplasia 1 (2%)
Trachea (50) (50) (50) (50)
Infiltration Cellular, Polymorphonuclear 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 88034-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:38:29
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1)
Cataract 1 (100%)
Harderian Gland (1) (8) (6) (4)
Hyperplasia 1 (13%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Cyst 1 (2%) 1 (2%) 1 (2%)
Infarct 3 (6%) 1 (2%) 1 (2%) 6 (12%)
Metaplasia, Osseous 1 (2%) 4 (8%)
Nephropathy 43 (86%) 40 (80%) 46 (92%) 37 (74%)
Papilla, Inflammation, Suppurative 6 (12%) 3 (6%) 8 (16%) 14 (28%)
Pelvis, Dilatation 3 (6%) 4 (8%) 4 (8%) 4 (8%)
Urethra (3)
Inflammation, Suppurative 1 (33%)
Bulbourethral Gland, Inflammation,
Suppurative 2 (67%)
Urinary Bladder (50) (50) (50) (49)
Inflammation, Chronic Active 6 (12%) 3 (6%) 8 (16%) 13 (27%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
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