TDMS Study 88034-06 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
OZONE
NTP Experiment-Test: 88034-06 Report: PEIRPT03
Study Type: CHRONIC 30-MONTH Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:21:59
Facility: Battelle Northwest
Chemical CAS #: 10028-15-6
Lock Date: 03/09/93
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 88034-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 30-MONTH OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:21:59
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Moribund Sacrifice 34 25 33
Natural Death 7 13 7
Survivors
Terminal Sacrifice 9 12 10
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (43) (38) (44)
Inflammation, Suppurative 1 (2%)
Epithelium, Hyperplasia 2 (5%)
Intestine Small, Duodenum (45) (41) (46)
Necrosis 1 (2%) 1 (2%)
Epithelium, Hyperplasia 1 (2%)
Peyer's Patch, Hyperplasia 1 (2%)
Liver (49) (50) (50)
Angiectasis 1 (2%) 1 (2%)
Basophilic Focus 1 (2%) 3 (6%)
Clear Cell Focus 1 (2%)
Degeneration, Fatty 1 (2%)
Eosinophilic Focus 3 (6%) 6 (12%) 3 (6%)
Hematopoietic Cell Proliferation 4 (8%) 4 (8%)
Inflammation, Chronic 2 (4%) 4 (8%) 1 (2%)
Necrosis 7 (14%) 3 (6%) 3 (6%)
Pigmentation 2 (4%) 2 (4%) 1 (2%)
Vacuolization Cytoplasmic, Focal 1 (2%)
Bile Duct, Cyst 1 (2%) 2 (4%)
Bile Duct, Hyperplasia 1 (2%) 1 (2%)
Centrilobular, Degeneration 1 (2%)
Centrilobular, Necrosis 1 (2%) 1 (2%)
Hepatocyte, Atrophy 1 (2%)
Mesentery (13) (5) (10)
Artery, Inflammation 1 (8%)
Fat, Inflammation, Chronic 1 (8%)
Fat, Necrosis 9 (69%) 2 (40%) 4 (40%)
Lymphatic, Angiectasis 1 (10%)
Pancreas (48) (48) (49)
Atrophy 5 (10%) 1 (2%) 3 (6%)
Basophilic Focus 5 (10%)
Inflammation 2 (4%) 1 (2%)
Duct, Cyst 2 (4%) 1 (2%) 2 (4%)
Stomach, Forestomach (48) (50) (49)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 88034-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 30-MONTH OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:21:59
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Inflammation, Suppurative 2 (4%) 3 (6%) 3 (6%)
Necrosis 1 (2%) 1 (2%) 1 (2%)
Epithelium, Hyperplasia 3 (6%) 2 (4%) 6 (12%)
Stomach, Glandular (48) (49) (48)
Inflammation, Acute 1 (2%)
Mineralization 1 (2%)
Necrosis 1 (2%) 1 (2%)
Epithelium, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50)
Cardiomyopathy 37 (74%) 38 (76%) 36 (72%)
Inflammation, Suppurative 1 (2%)
Necrosis 1 (2%)
Pigmentation, Hemosiderin 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (48) (49) (50)
Angiectasis 1 (2%)
Hyperplasia 3 (6%) 2 (4%) 3 (6%)
Hypertrophy 6 (13%) 5 (10%) 6 (12%)
Capsule, Hyperplasia 1 (2%) 2 (4%)
Adrenal Medulla (48) (49) (50)
Hyperplasia 4 (8%) 3 (6%) 4 (8%)
Islets, Pancreatic (47) (47) (48)
Hyperplasia 1 (2%)
Parathyroid Gland (36) (28) (29)
Hyperplasia 1 (3%)
Pituitary Gland (48) (48) (49)
Pars Distalis, Hyperplasia 11 (23%) 14 (29%) 16 (33%)
Pars Intermedia, Hyperplasia 1 (2%) 2 (4%) 1 (2%)
Pars Intermedia, Hypertrophy 1 (2%)
Thyroid Gland (49) (49) (50)
Follicular Cell, Hyperplasia 22 (45%) 24 (49%) 30 (60%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 88034-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 30-MONTH OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:21:59
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (45) (44) (42)
Inflammation, Chronic Active 1 (2%) 2 (5%)
Ovary (49) (48) (50)
Angiectasis 3 (6%) 2 (4%) 1 (2%)
Atrophy 28 (57%) 33 (69%) 30 (60%)
Cyst 23 (47%) 18 (38%) 16 (32%)
Inflammation, Chronic 1 (2%) 1 (2%)
Necrosis 1 (2%)
Germinal Epithelium, Hyperplasia 2 (4%) 4 (8%)
Interstitial Cell, Hyperplasia 2 (4%)
Uterus (49) (50) (50)
Angiectasis 4 (8%) 3 (6%) 2 (4%)
Cyst 6 (12%) 2 (4%) 9 (18%)
Decidual Reaction 1 (2%)
Hemorrhage 1 (2%)
Hydrometra 3 (6%) 5 (10%) 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Suppurative 1 (2%)
Thrombosis 2 (4%)
Endometrium, Hyperplasia 1 (2%) 2 (4%)
Myometrium, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (49) (50)
Angiectasis 2 (4%)
Hyperplasia 3 (6%) 1 (2%) 4 (8%)
Lymph Node (15) (6) (9)
Hyperplasia 1 (7%)
Iliac, Angiectasis 2 (13%)
Iliac, Hyperplasia 1 (7%)
Lumbar, Congestion 1 (7%)
Lumbar, Hyperplasia 1 (11%)
Renal, Congestion 1 (7%)
Renal, Hyperplasia 1 (11%)
Lymph Node, Bronchial (36) (32) (33)
Hyperplasia 1 (3%) 1 (3%) 1 (3%)
Infiltration Cellular, Plasma Cell 1 (3%)
Infiltration Cellular, Histiocyte 1 (3%)
Lymph Node, Mandibular (38) (40) (41)
Hematopoietic Cell Proliferation 1 (3%)
Hyperplasia 2 (5%) 4 (10%) 3 (7%)
Necrosis 1 (3%)
Lymph Node, Mesenteric (45) (48) (44)
Angiectasis 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 88034-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 30-MONTH OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:21:59
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Congestion 2 (4%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%)
Hyperplasia 1 (2%) 1 (2%)
Infiltration Cellular, Histiocyte 1 (2%)
Lymph Node, Mediastinal (43) (36) (38)
Hyperplasia 5 (12%) 9 (25%) 1 (3%)
Infiltration Cellular, Histiocyte 2 (5%)
Spleen (49) (50) (50)
Hematopoietic Cell Proliferation 15 (31%) 19 (38%) 21 (42%)
Hyperplasia, Histiocytic 1 (2%)
Hyperplasia, Lymphoid 6 (12%) 9 (18%) 4 (8%)
Infiltration Cellular, Histiocyte 1 (2%)
Thymus (35) (35) (33)
Atrophy 2 (6%) 3 (9%) 1 (3%)
Hyperplasia, Lymphoid 1 (3%) 2 (6%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50)
Hyperplasia 1 (2%) 1 (2%) 3 (6%)
Skin (50) (50) (50)
Inflammation, Chronic Active 1 (2%)
Inflammation, Suppurative 1 (2%)
Vulva, Inflammation, Suppurative 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50)
Chondradysplasia 1 (2%)
Fibrous Osteodystrophy 15 (30%) 18 (36%) 14 (28%)
Fracture 1 (2%)
Cranium, Fracture 1 (2%)
Cranium, Myelofibrosis 1 (2%)
Femur, Myelofibrosis 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (49) (49) (50)
Angiectasis 1 (2%)
Hydrocephalus 1 (2%)
Meninges, Infiltration Cellular 2 (4%) 2 (4%) 2 (4%)
Peripheral Nerve (1)
Degeneration 1 (100%)
Spinal Cord (1)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 88034-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 30-MONTH OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:21:59
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - CONT
Degeneration 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (49) (50)
Hyperplasia 13 (26%) 11 (22%) 24 (48%)
Inflammation, Chronic Active 4 (8%)
Inflammation, Suppurative 5 (10%) 4 (8%) 10 (20%)
Necrosis 2 (4%)
Epiglottis, Hyperplasia 4 (8%)
Epiglottis, Metaplasia, Squamous 2 (4%) 2 (4%) 19 (38%)
Lung (50) (49) (50)
Congestion, Chronic 2 (4%)
Hemorrhage 1 (2%) 2 (4%) 1 (2%)
Inflammation, Chronic, Focal 1 (2%)
Alveolar Epithelium, Hyperplasia 3 (6%) 1 (2%) 3 (6%)
Alveolar Epithelium, Metaplasia 43 (88%) 50 (100%)
Alveolus, Infiltration Cellular, Histiocyte 5 (10%) 39 (80%) 45 (90%)
Mediastinum, Angiectasis 1 (2%)
Mediastinum, Necrosis 1 (2%)
Perivascular, Infiltration Cellular 6 (12%) 1 (2%)
Nose (50) (49) (50)
Artery, Inflammation 1 (2%)
Lateral Wall, Degeneration, Hyaline 49 (100%) 50 (100%)
Lateral Wall, Fibrosis 1 (2%) 23 (47%) 48 (96%)
Lateral Wall, Hyperplasia 1 (2%) 42 (86%) 47 (94%)
Lateral Wall, Inflammation, Suppurative 3 (6%) 44 (90%) 50 (100%)
Lateral Wall, Metaplasia, Squamous 2 (4%) 3 (6%) 28 (56%)
Lateral Wall, Necrosis 1 (2%)
Nasolacrimal Duct, Inflammation, Suppurative 2 (4%) 1 (2%)
Olfactory Epithelium, Atrophy 9 (18%) 23 (47%) 40 (80%)
Turbinate, Hyperplasia 1 (2%)
Turbinate, Inflammation, Suppurative 1 (2%)
Trachea (48) (48) (50)
Metaplasia, Squamous 1 (2%)
Mineralization 1 (2%)
Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1)
Inflammation, Granulomatous 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 88034-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 30-MONTH OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:21:59
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (49) (50)
Fibrosis, Focal 1 (2%)
Glomerulosclerosis 2 (4%)
Hydronephrosis 1 (2%) 2 (4%)
Infarct 1 (2%)
Karyomegaly 2 (4%)
Metaplasia, Osseous 4 (8%) 1 (2%) 5 (10%)
Mineralization 1 (2%)
Nephropathy 24 (49%) 27 (55%) 30 (60%)
Cortex, Inflammation, Suppurative 1 (2%)
Pelvis, Dilatation 1 (2%)
Renal Tubule, Hyperplasia 2 (4%)
Urinary Bladder (47) (48) (46)
Inflammation, Suppurative 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 88034-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 30-MONTH OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:21:59
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Natural Death 10 9 15
Moribund Sacrifice 26 30 23
Survivors
Terminal Sacrifice 14 11 12
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (43) (44) (40)
Inflammation, Suppurative 1 (2%) 2 (5%)
Mineralization 1 (3%)
Epithelium, Hyperplasia 1 (2%)
Intestine Small, Duodenum (44) (45) (38)
Necrosis 1 (2%)
Intestine Small, Jejunum (43) (44) (41)
Peyer's Patch, Hyperplasia 2 (5%)
Liver (49) (50) (50)
Angiectasis 1 (2%)
Basophilic Focus 2 (4%) 1 (2%) 2 (4%)
Clear Cell Focus 1 (2%)
Degeneration, Fatty 2 (4%) 1 (2%) 2 (4%)
Eosinophilic Focus 10 (20%) 9 (18%) 3 (6%)
Hematopoietic Cell Proliferation 2 (4%) 1 (2%) 1 (2%)
Hepatodiaphragmatic Nodule 1 (2%) 1 (2%)
Infiltration Cellular, Mast Cell 1 (2%)
Inflammation, Chronic 2 (4%) 1 (2%) 1 (2%)
Necrosis 3 (6%) 8 (16%) 3 (6%)
Bile Duct, Cyst 1 (2%) 1 (2%) 2 (4%)
Centrilobular, Necrosis 1 (2%) 1 (2%)
Mesentery (3) (3) (4)
Artery, Inflammation, Chronic Active 1 (25%)
Fat, Necrosis 1 (33%) 1 (33%) 2 (50%)
Pancreas (49) (49) (49)
Atrophy 3 (6%) 3 (6%) 1 (2%)
Basophilic Focus 1 (2%)
Cytoplasmic Alteration 1 (2%)
Vacuolization Cytoplasmic 1 (2%)
Duct, Cyst 1 (2%)
Stomach, Forestomach (49) (49) (50)
Angiectasis 1 (2%)
Infiltration Cellular, Mast Cell 1 (2%)
Inflammation, Suppurative 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 88034-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 30-MONTH OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:21:59
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Necrosis 3 (6%)
Epithelium, Hyperplasia 1 (2%) 4 (8%) 3 (6%)
Stomach, Glandular (49) (47) (48)
Inflammation, Acute 1 (2%) 1 (2%)
Mineralization 1 (2%)
Necrosis 2 (4%) 3 (6%) 1 (2%)
Epithelium, Hyperplasia 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1)
Mineralization 1 (100%)
Heart (50) (50) (50)
Cardiomyopathy 40 (80%) 40 (80%) 40 (80%)
Inflammation, Suppurative 2 (4%)
Mineralization 1 (2%)
Necrosis 1 (2%) 1 (2%)
Artery, Inflammation, Chronic Active 1 (2%)
Atrium, Thrombosis 2 (4%) 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (47) (49) (49)
Hyperplasia 9 (19%) 13 (27%) 8 (16%)
Hypertrophy 20 (43%) 16 (33%) 13 (27%)
Capsule, Hyperplasia 9 (19%) 12 (24%) 7 (14%)
Adrenal Medulla (48) (48) (49)
Hyperplasia 2 (4%) 2 (4%)
Thrombosis 1 (2%)
Islets, Pancreatic (49) (49) (49)
Hyperplasia 4 (8%) 1 (2%) 2 (4%)
Pituitary Gland (47) (49) (48)
Pars Distalis, Hyperplasia 1 (2%) 4 (8%) 3 (6%)
Pars Intermedia, Hyperplasia 1 (2%) 2 (4%)
Thyroid Gland (49) (48) (50)
Follicular Cell, Hyperplasia 18 (37%) 20 (42%) 32 (64%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 88034-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 30-MONTH OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:21:59
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (49) (49) (50)
Atrophy 1 (2%)
Granuloma Sperm 1 (2%) 1 (2%)
Inflammation 2 (4%) 1 (2%)
Inflammation, Chronic 1 (2%)
Penis (4) (2) (7)
Inflammation, Suppurative 3 (75%) 2 (100%) 5 (71%)
Preputial Gland (49) (49) (49)
Cyst 11 (22%) 11 (22%) 8 (16%)
Hyperplasia 1 (2%)
Inflammation, Chronic Active 15 (31%) 13 (27%) 9 (18%)
Prostate (48) (47) (47)
Hyperplasia 1 (2%)
Inflammation, Suppurative 3 (6%) 5 (11%) 3 (6%)
Artery, Inflammation, Chronic Active 1 (2%)
Seminal Vesicle (48) (49) (49)
Hyperplasia 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (2%)
Testes (50) (49) (50)
Atrophy 11 (22%) 10 (20%) 5 (10%)
Mineralization 1 (2%) 1 (2%)
Interstitial Cell, Hyperplasia 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (49) (50)
Hyperplasia 3 (6%) 5 (10%) 4 (8%)
Hyperplasia, Megakaryocyte 1 (2%)
Infiltration Cellular, Mast Cell 1 (2%)
Necrosis 1 (2%)
Lymph Node (2) (3) (7)
Congestion 1 (14%)
Iliac, Hyperplasia 2 (29%)
Iliac, Infiltration Cellular, Plasma Cell 1 (50%)
Iliac, Pigmentation 1 (33%)
Renal, Hyperplasia 2 (29%)
Lymph Node, Bronchial (26) (27) (32)
Hyperplasia 1 (4%) 2 (6%)
Lymph Node, Mandibular (34) (31) (32)
Hyperplasia 1 (3%) 1 (3%)
Infiltration Cellular, Mast Cell 1 (3%)
Lymph Node, Mesenteric (48) (46) (44)
Angiectasis 3 (6%) 4 (9%)
Congestion 1 (2%) 2 (4%)
Hematopoietic Cell Proliferation 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 88034-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 30-MONTH OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:21:59
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hemorrhage 1 (2%)
Hyperplasia 2 (4%) 2 (4%) 3 (7%)
Lymph Node, Mediastinal (37) (39) (43)
Hyperplasia 1 (3%) 5 (13%) 5 (12%)
Spleen (49) (49) (50)
Angiectasis 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation 14 (29%) 14 (29%) 15 (30%)
Hyperplasia, Lymphoid 2 (4%) 2 (4%) 1 (2%)
Infiltration Cellular, Mast Cell 1 (2%)
Pigmentation, Melanin 1 (2%)
Thymus (29) (26) (25)
Atrophy 4 (14%) 1 (4%) 5 (20%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (49) (50) (50)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Epidermis, Hyperplasia 2 (4%)
Prepuce, Inflammation, Chronic Active 11 (22%) 13 (26%) 16 (32%)
Subcutaneous Tissue, Edema 1 (2%)
Subcutaneous Tissue, Hemorrhage 1 (2%)
Subcutaneous Tissue, Infiltration Cellular,
Mast Cell 1 (2%)
Subcutaneous Tissue, Inflammation, Chronic 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50)
Fibrous Osteodystrophy 1 (2%) 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (49) (49) (50)
Developmental Malformation 1 (2%)
Hemorrhage 1 (2%)
Hydrocephalus 1 (2%)
Artery, Inflammation, Chronic Active 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 88034-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 30-MONTH OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:21:59
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (49) (49) (50)
Hyperplasia 4 (8%) 7 (14%) 15 (30%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Chronic Active 6 (12%) 7 (14%) 7 (14%)
Inflammation, Suppurative 1 (2%) 5 (10%) 4 (8%)
Epiglottis, Hyperplasia 1 (2%) 2 (4%) 2 (4%)
Epiglottis, Metaplasia, Squamous 2 (4%) 1 (2%) 10 (20%)
Lung (49) (49) (50)
Angiectasis 1 (2%)
Hemorrhage 1 (2%)
Inflammation, Chronic, Focal 1 (2%)
Alveolar Epithelium, Hyperplasia 10 (20%) 8 (16%) 1 (2%)
Alveolar Epithelium, Metaplasia 48 (98%) 47 (94%)
Alveolus, Infiltration Cellular, Histiocyte 3 (6%) 40 (82%) 41 (82%)
Bronchiole, Metaplasia 1 (2%)
Bronchiole, Necrosis 1 (2%)
Perivascular, Infiltration Cellular 1 (2%) 3 (6%)
Nose (49) (48) (49)
Lateral Wall, Degeneration, Hyaline 2 (4%) 48 (100%) 49 (100%)
Lateral Wall, Fibrosis 8 (17%) 43 (88%)
Lateral Wall, Hyperplasia 2 (4%) 33 (69%) 45 (92%)
Lateral Wall, Inflammation, Suppurative 1 (2%) 38 (79%) 46 (94%)
Lateral Wall, Metaplasia, Squamous 1 (2%) 2 (4%) 20 (41%)
Nasolacrimal Duct, Inflammation, Suppurative 2 (4%) 2 (4%) 2 (4%)
Olfactory Epithelium, Atrophy 4 (8%) 4 (8%) 18 (37%)
Trachea (49) (49) (49)
Hyperplasia 1 (2%)
Metaplasia, Squamous 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (3) (1) (1)
Inflammation 2 (67%) 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (49) (50)
Cyst 4 (8%) 1 (2%) 3 (6%)
Hydronephrosis 1 (2%)
Infarct 1 (2%) 1 (2%)
Mineralization 2 (4%)
Nephropathy 40 (82%) 43 (88%) 37 (74%)
Cortex, Inflammation, Suppurative 2 (4%) 3 (6%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 88034-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 30-MONTH OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:21:59
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Papilla, Inflammation, Suppurative 3 (6%) 6 (12%) 6 (12%)
Papilla, Necrosis 1 (2%)
Pelvis, Dilatation 2 (4%) 1 (2%)
Renal Tubule, Hyperplasia 1 (2%)
Urinary Bladder (47) (49) (48)
Calculus Gross Observation 3 (6%)
Inflammation, Chronic Active 2 (4%) 1 (2%) 2 (4%)
Inflammation, Suppurative 1 (2%) 5 (10%) 5 (10%)
Transitional Epithelium, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------