TDMS Study 88034-06 Pathology Tables
NTP Experiment-Test: 88034-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:41:57 Facility: Battelle Northwest Chemical CAS #: 10028-15-6 Lock Date: 03/09/93 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Note: Animals arranged according to CID number Page 1 NTP Experiment-Test: 88034-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:41:57 _____________________________________________________________________________________________________________________ | 7| 8| 8| 8| 6| 9| 4| 5| 8| 9| 7| 7| 9| 9| 5| 8| 7| 7| 8| 8| 5| 7| 8| 8| 8| DAY ON TEST | 7| 0| 6| 4| 2| 1| 0| 5| 4| 1| 9| 9| 1| 1| 3| 4| 4| 4| 6| 4| 2| 2| 0| 7| 2| | 8| 5| 0| 0| 1| 1| 3| 6| 0| 2| 1| 0| 2| 2| 7| 7| 9| 9| 9| 1| 1| 4| 1| 5| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + I + + + + + + + A + + + + +| Lymphoma Malignant | X | Sarcoma, Metastatic, Skin | X | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + A + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + A + + + + + + + M + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + A + + + + + + + A + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + A + + + + + + + A + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + A + + + + + + + A + + + + +| Lymphoma Malignant | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + A + + + + + + + A + + + + +| Lymphoma Malignant | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | X X X X X X X| Hepatocellular Carcinoma, Multiple | X X X | Hepatocellular Adenoma | X X X X | Hepatocellular Adenoma, Multiple | X | Histiocytic Sarcoma | X X| Lymphoma Malignant | X X X | __________________________________________________________________________| Mesentery | + + + + | Lymphoma Malignant | | Sarcoma, Metastatic, Skin | X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X| Lymphoma Malignant | X X X | Sarcoma, Metastatic, Skin | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | Sarcoma | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Sarcoma, Metastatic, Skin | X | Squamous Cell Papilloma | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | Sarcoma, Metastatic, Skin | X | __________________________________________________________________________| Tooth | | Adamantinoma Malignant | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | _____________________________________________________________________________________________________________________| Page 2 NTP Experiment-Test: 88034-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:41:57 _____________________________________________________________________________________________________________________ | 7| 8| 8| 8| 6| 9| 4| 5| 8| 9| 7| 7| 9| 9| 5| 8| 7| 7| 8| 8| 5| 7| 8| 8| 8| DAY ON TEST | 7| 0| 6| 4| 2| 1| 0| 5| 4| 1| 9| 9| 1| 1| 3| 4| 4| 4| 6| 4| 2| 2| 0| 7| 2| | 8| 5| 0| 0| 1| 1| 3| 6| 0| 2| 1| 0| 2| 2| 7| 7| 9| 9| 9| 1| 1| 4| 1| 5| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Capsule, Adenoma | X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | Pheochromocytoma Benign | X X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | __________________________________________________________________________| Parathyroid Gland | + + M + + + + + M + + + + + + M + + + + + + + + M| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + I + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X X X X X X X | Pars Intermedia, Adenoma | X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Adenoma, Multiple | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + M + + + + + M + + + + + + +| __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cystadenoma | X X | Hemangioma | | Histiocytic Sarcoma | X| Luteoma | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Fibroma | | Hemangioma | X | Histiocytic Sarcoma | X X| Lymphoma Malignant | X X | Polyp Stromal | X X X| Polyp Stromal, Multiple | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Histiocytic Sarcoma | X| Lymphoma Malignant | | __________________________________________________________________________| Lymph Node | + + + + + + + +| Lymphoma Malignant | X X | Iliac, Histiocytic Sarcoma | X X| Iliac, Lymphoma Malignant | X X | Pancreatic, Histiocytic Sarcoma | X| Pancreatic, Lymphoma Malignant | | Renal, Histiocytic Sarcoma | X| _____________________________________________________________________________________________________________________| Page 3 NTP Experiment-Test: 88034-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:41:57 _____________________________________________________________________________________________________________________ | 7| 8| 8| 8| 6| 9| 4| 5| 8| 9| 7| 7| 9| 9| 5| 8| 7| 7| 8| 8| 5| 7| 8| 8| 8| DAY ON TEST | 7| 0| 6| 4| 2| 1| 0| 5| 4| 1| 9| 9| 1| 1| 3| 4| 4| 4| 6| 4| 2| 2| 0| 7| 2| | 8| 5| 0| 0| 1| 1| 3| 6| 0| 2| 1| 0| 2| 2| 7| 7| 9| 9| 9| 1| 1| 4| 1| 5| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Renal, Lymphoma Malignant | X X | __________________________________________________________________________| Lymph Node, Bronchial | + + + + M + + + M + + + + + + + M M + + + + M M M| Histiocytic Sarcoma | X | Lymphoma Malignant | X X X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + M + + + M + + M + + + M + + + M +| Histiocytic Sarcoma | X| Lymphoma Malignant | X X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + M + + + + M + + + + + + + + M + + + + +| Histiocytic Sarcoma | X X| Lymphoma Malignant | X X | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + M + M + + + + + + + + + + + + + + M + + +| Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | X | Histiocytic Sarcoma | X X| Lymphoma Malignant | X X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X X | Histiocytic Sarcoma | X| Lymphoma Malignant | X X | Sarcoma, Metastatic, Skin | X | __________________________________________________________________________| Thymus | M + M + M + + + M + M + + + + + M + + + + + + + M| Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | X | Lymphoma Malignant | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Carcinoma | X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | Subcutaneous Tissue, Hemangiosarcoma | X | Subcutaneous Tissue, Histiocytic | | Sarcoma | X | Subcutaneous Tissue, Sarcoma | | Subcutaneous Tissue, Sarcoma, | | Multiple | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteosarcoma | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 4 NTP Experiment-Test: 88034-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:41:57 _____________________________________________________________________________________________________________________ | 7| 8| 8| 8| 6| 9| 4| 5| 8| 9| 7| 7| 9| 9| 5| 8| 7| 7| 8| 8| 5| 7| 8| 8| 8| DAY ON TEST | 7| 0| 6| 4| 2| 1| 0| 5| 4| 1| 9| 9| 1| 1| 3| 4| 4| 4| 6| 4| 2| 2| 0| 7| 2| | 8| 5| 0| 0| 1| 1| 3| 6| 0| 2| 1| 0| 2| 2| 7| 7| 9| 9| 9| 1| 1| 4| 1| 5| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM - cont | | | | Carcinoma, Metastatic, Harderian | | Gland | X | Histiocytic Sarcoma | X| __________________________________________________________________________| Peripheral Nerve | + | __________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Adamantinoma Malignant, Metastatic, | | Tooth | | Alveolar/Bronchiolar Adenoma | X X | Alveolar/Bronchiolar Carcinoma | X | Alveolar/Bronchiolar Carcinoma, | | Multiple | X X | Carcinoma, Metastatic, Harderian | | Gland | X | Hepatocellular Carcinoma, Metastatic,| | Liver | | Histiocytic Sarcoma | X| Lymphoma Malignant | X | Osteosarcoma, Metastatic, Bone | X | Mediastinum, Alveolar/Bronchiolar | | Carcinoma, Metastatic, Lung | X X | Mediastinum, Lymphoma Malignant | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Harderian | | Gland | X | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | + + | Adenoma | X | Carcinoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X| Lymphoma Malignant | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + A + + + + +| Hemangioma | X| Lymphoma Malignant | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 5 NTP Experiment-Test: 88034-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:41:57 _____________________________________________________________________________________________________________________ | 7| 8| 8| 8| 6| 9| 4| 5| 8| 9| 7| 7| 9| 9| 5| 8| 7| 7| 8| 8| 5| 7| 8| 8| 8| DAY ON TEST | 7| 0| 6| 4| 2| 1| 0| 5| 4| 1| 9| 9| 1| 1| 3| 4| 4| 4| 6| 4| 2| 2| 0| 7| 2| | 8| 5| 0| 0| 1| 1| 3| 6| 0| 2| 1| 0| 2| 2| 7| 7| 9| 9| 9| 1| 1| 4| 1| 5| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS - cont | | | | Histiocytic Sarcoma | X X X| Lymphoma Malignant | X X X X | _____________________________________________________________________________________________________________________| Page 6 NTP Experiment-Test: 88034-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:41:57 __________________________________________________________________________________________________________________________________ | 9| 7| 9| 7| 7| 8| 6| 7| 8| 9| 5| 8| 8| 9| 7| 7| 7| 7| 7| 9| 8| 8| 8| 4| 5| | DAY ON TEST | 1| 2| 1| 2| 7| 8| 7| 9| 8| 1| 2| 4| 6| 1| 5| 9| 9| 1| 2| 1| 5| 2| 2| 0| 4| | | 1| 1| 2| 1| 5| 4| 8| 1| 3| 1| 7| 9| 5| 2| 4| 1| 6| 7| 2| 2| 7| 6| 4| 8| 7| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + A + + + + + + +| 49 | __________________________________________________________________________|____________| Gallbladder | + + + + A + + + + + + A A + + + + A + + + + + A +| 43 | Lymphoma Malignant | | 1 | Sarcoma, Metastatic, Skin | | 1 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + A + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + A + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + A + + + + + + + + + + + + A + + + + + A +| 45 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + A + + + + + + + A + + + + + + + + + + A +| 45 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + A + + + + + + + A + + + + A + + + + + A +| 44 | Lymphoma Malignant | X | 1 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + A + + + + A + + + + + A +| 45 | Lymphoma Malignant | X X | 2 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + A + + + + + + +| 49 | Hepatocellular Carcinoma | X X X X X X X X| 15 | Hepatocellular Carcinoma, Multiple | X | 4 | Hepatocellular Adenoma | X X X X X X X | 11 | Hepatocellular Adenoma, Multiple | X | 2 | Histiocytic Sarcoma | X | 3 | Lymphoma Malignant | X X X X X | 8 | __________________________________________________________________________|____________| Mesentery | + + + + + + + + + | 13 | Lymphoma Malignant | X | 1 | Sarcoma, Metastatic, Skin | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + A + + + + + + + + + + + + A + + + + + + +| 48 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant | X | 4 | Sarcoma, Metastatic, Skin | | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X | 1 | Sarcoma | X | 1 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + A + + + + + A +| 48 | Sarcoma, Metastatic, Skin | | 1 | Squamous Cell Papilloma | X | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + A + + + + + A +| 48 | Lymphoma Malignant | X | 1 | Sarcoma, Metastatic, Skin | | 1 | __________________________________________________________________________|____________| Tooth | + | 1 | Adamantinoma Malignant | X | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 7 NTP Experiment-Test: 88034-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:41:57 __________________________________________________________________________________________________________________________________ | 9| 7| 9| 7| 7| 8| 6| 7| 8| 9| 5| 8| 8| 9| 7| 7| 7| 7| 7| 9| 8| 8| 8| 4| 5| | DAY ON TEST | 1| 2| 1| 2| 7| 8| 7| 9| 8| 1| 2| 4| 6| 1| 5| 9| 9| 1| 2| 1| 5| 2| 2| 0| 4| | | 1| 1| 2| 1| 5| 4| 8| 1| 3| 1| 7| 9| 5| 2| 4| 1| 6| 7| 2| 2| 7| 6| 4| 8| 7| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + M A + + + + + + +| 48 | Lymphoma Malignant | | 1 | Capsule, Adenoma | | 1 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + M A + + + + + + +| 48 | Lymphoma Malignant | | 1 | Pheochromocytoma Benign | | 2 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + A M + + + + + + + + + + + A + + + + + + +| 47 | Adenoma | | 1 | __________________________________________________________________________|____________| Parathyroid Gland | M + + M M + + M + + + + M + + + M M + M + + + M M| 36 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + A + + + + + + +| 48 | Pars Distalis, Adenoma | X X X X X X X X X| 19 | Pars Intermedia, Adenoma | | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + A + + + + + + +| 49 | Follicular Cell, Adenoma, Multiple | X | 2 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + M M + + + + + + + + + + M +| 45 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + A + + + + + + +| 49 | Cystadenoma | X X | 4 | Hemangioma | X | 1 | Histiocytic Sarcoma | X | 2 | Luteoma | X | 1 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + A + + + + + + +| 49 | Adenoma | | 1 | Fibroma | X | 1 | Hemangioma | | 1 | Histiocytic Sarcoma | X | 3 | Lymphoma Malignant | X | 3 | Polyp Stromal | | 3 | Polyp Stromal, Multiple | X | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + A + + + + + + +| 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 8 NTP Experiment-Test: 88034-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:41:57 __________________________________________________________________________________________________________________________________ | 9| 7| 9| 7| 7| 8| 6| 7| 8| 9| 5| 8| 8| 9| 7| 7| 7| 7| 7| 9| 8| 8| 8| 4| 5| | DAY ON TEST | 1| 2| 1| 2| 7| 8| 7| 9| 8| 1| 2| 4| 6| 1| 5| 9| 9| 1| 2| 1| 5| 2| 2| 0| 4| | | 1| 1| 2| 1| 5| 4| 8| 1| 3| 1| 7| 9| 5| 2| 4| 1| 6| 7| 2| 2| 7| 6| 4| 8| 7| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Hemangiosarcoma | | 1 | Histiocytic Sarcoma | X | 2 | Lymphoma Malignant | X X X X | 4 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + | 15 | Lymphoma Malignant | X X | 4 | Iliac, Histiocytic Sarcoma | | 2 | Iliac, Lymphoma Malignant | X X X X | 6 | Pancreatic, Histiocytic Sarcoma | | 1 | Pancreatic, Lymphoma Malignant | X | 1 | Renal, Histiocytic Sarcoma | | 1 | Renal, Lymphoma Malignant | X X X X X | 7 | __________________________________________________________________________|____________| Lymph Node, Bronchial | M + + + + + + + + + + M M + M + + + M M M + + + +| 36 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant | X X X X X X | 9 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + M + + M + + + + + + + M + + M M A + + + + + M +| 38 | Histiocytic Sarcoma | X | 2 | Lymphoma Malignant | X X X | 5 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + A + + + + + A +| 45 | Histiocytic Sarcoma | X | 3 | Lymphoma Malignant | X X X X X X | 8 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + M + + + M + + + + + + M + + + + + + + + + M +| 43 | Alveolar/Bronchiolar Carcinoma, | | | Metastatic, Lung | | 1 | Histiocytic Sarcoma | | 2 | Lymphoma Malignant | X X X X X X X | 10 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + A + + + + + + +| 49 | Hemangiosarcoma | | 2 | Histiocytic Sarcoma | X | 2 | Lymphoma Malignant | X X X X X | 7 | Sarcoma, Metastatic, Skin | | 1 | __________________________________________________________________________|____________| Thymus | + + + M + + M M + M + + + + + M + + M M + M + + +| 35 | Alveolar/Bronchiolar Carcinoma, | | | Metastatic, Lung | | 1 | Lymphoma Malignant | X X X X | 5 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X | 1 | Carcinoma | X X | 3 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 9 NTP Experiment-Test: 88034-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:41:57 __________________________________________________________________________________________________________________________________ | 9| 7| 9| 7| 7| 8| 6| 7| 8| 9| 5| 8| 8| 9| 7| 7| 7| 7| 7| 9| 8| 8| 8| 4| 5| | DAY ON TEST | 1| 2| 1| 2| 7| 8| 7| 9| 8| 1| 2| 4| 6| 1| 5| 9| 9| 1| 2| 1| 5| 2| 2| 0| 4| | | 1| 1| 2| 1| 5| 4| 8| 1| 3| 1| 7| 9| 5| 2| 4| 1| 6| 7| 2| 2| 7| 6| 4| 8| 7| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X | 1 | Subcutaneous Tissue, Hemangiosarcoma | | 1 | Subcutaneous Tissue, Histiocytic | | | Sarcoma | | 1 | Subcutaneous Tissue, Sarcoma | X | 1 | Subcutaneous Tissue, Sarcoma, | | | Multiple | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Osteosarcoma | X | 2 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + A + + + + + + +| 49 | Carcinoma, Metastatic, Harderian | | | Gland | | 1 | Histiocytic Sarcoma | | 1 | __________________________________________________________________________|____________| Peripheral Nerve | | 1 | __________________________________________________________________________|____________| Spinal Cord | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adamantinoma Malignant, Metastatic, | | | Tooth | X | 1 | Alveolar/Bronchiolar Adenoma | X | 3 | Alveolar/Bronchiolar Carcinoma | | 1 | Alveolar/Bronchiolar Carcinoma, | | | Multiple | | 2 | Carcinoma, Metastatic, Harderian | | | Gland | | 1 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X X | 2 | Histiocytic Sarcoma | X | 2 | Lymphoma Malignant | X X X | 4 | Osteosarcoma, Metastatic, Bone | | 1 | Mediastinum, Alveolar/Bronchiolar | | | Carcinoma, Metastatic, Lung | | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 10 NTP Experiment-Test: 88034-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:41:57 __________________________________________________________________________________________________________________________________ | 9| 7| 9| 7| 7| 8| 6| 7| 8| 9| 5| 8| 8| 9| 7| 7| 7| 7| 7| 9| 8| 8| 8| 4| 5| | DAY ON TEST | 1| 2| 1| 2| 7| 8| 7| 9| 8| 1| 2| 4| 6| 1| 5| 9| 9| 1| 2| 1| 5| 2| 2| 0| 4| | | 1| 1| 2| 1| 5| 4| 8| 1| 3| 1| 7| 9| 5| 2| 4| 1| 6| 7| 2| 2| 7| 6| 4| 8| 7| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Mediastinum, Lymphoma Malignant | X | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Harderian | | | Gland | | 1 | __________________________________________________________________________|____________| Trachea | + + + + A + + + + + + + + + + + + A + + + + + + +| 48 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Harderian Gland | + + + | 5 | Adenoma | X X X | 4 | Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + A + + + + + + +| 49 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant | X | 2 | __________________________________________________________________________|____________| Urinary Bladder | + + + + A + + + + + + + + + + + + A + + + + + + +| 47 | Hemangioma | | 1 | Lymphoma Malignant | X X | 2 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | X | 4 | Lymphoma Malignant | X X X X X X X X X | 13 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 11 NTP Experiment-Test: 88034-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:41:57 _____________________________________________________________________________________________________________________ | 5| 8| 8| 8| 7| 8| 8| 8| 9| 9| 8| 9| 9| 7| 8| 9| 5| 9| 7| 7| 6| 8| 8| 6| 7| DAY ON TEST | 7| 0| 6| 2| 8| 7| 5| 2| 1| 1| 0| 1| 1| 9| 6| 1| 4| 1| 8| 7| 7| 8| 7| 9| 5| | 1| 5| 3| 1| 5| 7| 5| 6| 2| 2| 7| 2| 2| 2| 1| 2| 4| 1| 4| 5| 8| 0| 5| 1| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + A + M A + + + + + + + + + + M + + + + A A| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + A + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + A + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + A + + A + + + + + + + + + + A + + + + A +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + + A + + + + A A| Lymphoma Malignant | | __________________________________________________________________________| Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + A + + + + A A| __________________________________________________________________________| Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + A + + + + A +| Carcinoma | X | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Hepatocellular Carcinoma | X X X X X X X| Hepatocellular Carcinoma, Multiple | X | Hepatocellular Adenoma | X X X X X X X X | Hepatocellular Adenoma, Multiple | X X X | Hepatocholangiocarcinoma | X | Lymphoma Malignant | X X | Osteosarcoma, Metastatic, Bone | | __________________________________________________________________________| Mesentery | + + + | Hemangiosarcoma | X | Lymphoma Malignant | X X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + A + + + + + +| Lymphoma Malignant | X X X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + M + + + + + +| Lymphoma Malignant | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocholangiocarcinoma, Metastatic,| | Liver | X | Lymphoma Malignant | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Benign | X X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + A M + + + + +| __________________________________________________________________________| Parathyroid Gland | + M + M M M M M + M + M M + + + + + + M I + + M +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 12 NTP Experiment-Test: 88034-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:41:57 _____________________________________________________________________________________________________________________ | 5| 8| 8| 8| 7| 8| 8| 8| 9| 9| 8| 9| 9| 7| 8| 9| 5| 9| 7| 7| 6| 8| 8| 6| 7| DAY ON TEST | 7| 0| 6| 2| 8| 7| 5| 2| 1| 1| 0| 1| 1| 9| 6| 1| 4| 1| 8| 7| 7| 8| 7| 9| 5| | 1| 5| 3| 1| 5| 7| 5| 6| 2| 2| 7| 2| 2| 2| 1| 2| 4| 1| 4| 5| 8| 0| 5| 1| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Pars Distalis, Adenoma | X X X X X X X | Pars Distalis, Carcinoma | X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + M + + + + + + + + + + + + + + M + + + + + +| __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cystadenoma | X| Granulosa Cell Tumor Benign | | Luteoma | | Lymphoma Malignant | X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Lymphoma Malignant | X X | Polyp Stromal | X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X X X | __________________________________________________________________________| Lymph Node | + + + | Lymphoma Malignant | X X | Iliac, Lymphoma Malignant | X X | Pancreatic, Lymphoma Malignant | X | Renal, Lymphoma Malignant | X X | __________________________________________________________________________| Lymph Node, Bronchial | + M + M + + + M M + + + M + M M + + + + + M M M M| Hepatocholangiocarcinoma, Metastatic,| | Liver | X | Lymphoma Malignant | X X X X | __________________________________________________________________________| Lymph Node, Mandibular | + + + I + + + + + + + + + + + M + M + + + + + + M| Lymphoma Malignant | X X X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X X X X X | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + + + + M M M M + + + + + + + M + M| Hepatocholangiocarcinoma, Metastatic,| | Liver | X | Lymphoma Malignant | X X X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X X X | Lymphoma Malignant | X X X | __________________________________________________________________________| Thymus | M + + + + M M + + + + + M + + M + + + + M + M + +| _____________________________________________________________________________________________________________________| Page 13 NTP Experiment-Test: 88034-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:41:57 _____________________________________________________________________________________________________________________ | 5| 8| 8| 8| 7| 8| 8| 8| 9| 9| 8| 9| 9| 7| 8| 9| 5| 9| 7| 7| 6| 8| 8| 6| 7| DAY ON TEST | 7| 0| 6| 2| 8| 7| 5| 2| 1| 1| 0| 1| 1| 9| 6| 1| 4| 1| 8| 7| 7| 8| 7| 9| 5| | 1| 5| 3| 1| 5| 7| 5| 6| 2| 2| 7| 2| 2| 2| 1| 2| 4| 1| 4| 5| 8| 0| 5| 1| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Lymphoma Malignant | X X X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Schwannoma Malignant | | Subcutaneous Tissue, Hemangiosarcoma | X | Subcutaneous Tissue, Sarcoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteosarcoma | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Pituitary | | Gland | X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X | Alveolar/Bronchiolar Carcinoma | X X | Carcinoma, Metastatic, Harderian | | Gland | | Hepatocellular Carcinoma, Metastatic,| | Liver | X | Hepatocholangiocarcinoma, Metastatic,| | Liver | X | Lymphoma Malignant | X X | Osteosarcoma, Metastatic, Bone | | Mediastinum, Hemangiosarcoma | | Mediastinum, | | Hepatocholangiocarcinoma, | | Metastatic, Liver | X | Mediastinum, Osteosarcoma, | | Metastatic, Bone | | Mediastinum, Sarcoma, Metastatic, | | Skin | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + A + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 14 NTP Experiment-Test: 88034-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:41:57 _____________________________________________________________________________________________________________________ | 5| 8| 8| 8| 7| 8| 8| 8| 9| 9| 8| 9| 9| 7| 8| 9| 5| 9| 7| 7| 6| 8| 8| 6| 7| DAY ON TEST | 7| 0| 6| 2| 8| 7| 5| 2| 1| 1| 0| 1| 1| 9| 6| 1| 4| 1| 8| 7| 7| 8| 7| 9| 5| | 1| 5| 3| 1| 5| 7| 5| 6| 2| 2| 7| 2| 2| 2| 1| 2| 4| 1| 4| 5| 8| 0| 5| 1| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | __________________________________________________________________________| Ear | | __________________________________________________________________________| Harderian Gland | + + | Adenoma | X X | Carcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocholangiocarcinoma, Metastatic,| | Liver | X | Lymphoma Malignant | X X X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + A + + + + + +| Lymphoma Malignant | X X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X X X X X | _____________________________________________________________________________________________________________________| Page 15 NTP Experiment-Test: 88034-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:41:57 __________________________________________________________________________________________________________________________________ | 7| 9| 9| 9| 8| 6| 5| 6| 7| 8| 9| 9| 7| 8| 8| 9| 8| 7| 6| 8| 7| 7| 7| 6| 8| | DAY ON TEST | 2| 1| 1| 1| 7| 2| 9| 1| 6| 5| 1| 1| 8| 8| 8| 1| 7| 5| 2| 1| 6| 9| 2| 1| 5| | | 6| 2| 2| 1| 5| 1| 5| 6| 3| 5| 2| 1| 6| 0| 3| 2| 4| 0| 3| 7| 6| 2| 1| 6| 5| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | + + + + A A + + + + + + A + + + + + + + A A + A +| 38 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + M + + A + + + +| 47 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + A + + + + + + + A + + A +| 43 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + A + + A + + + + M + + + + + M + A + + + +| 41 | Lymphoma Malignant | X | 1 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + A A + A + + + + + + + + + + + + A + + + +| 42 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + A A + + + + + + A + + + + + + + A + + + +| 43 | Carcinoma | | 1 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | | 1 | Hepatocellular Carcinoma | X X X X X X X X | 15 | Hepatocellular Carcinoma, Multiple | X X | 3 | Hepatocellular Adenoma | X X X X| 12 | Hepatocellular Adenoma, Multiple | X | 4 | Hepatocholangiocarcinoma | | 1 | Lymphoma Malignant | X X X X | 6 | Osteosarcoma, Metastatic, Bone | X | 1 | __________________________________________________________________________|____________| Mesentery | + + | 5 | Hemangiosarcoma | | 1 | Lymphoma Malignant | | 2 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 | Lymphoma Malignant | | 3 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 | Lymphoma Malignant | X | 1 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 | Lymphoma Malignant | | 2 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hepatocholangiocarcinoma, Metastatic,| | | Liver | | 1 | Lymphoma Malignant | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 | Lymphoma Malignant | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 16 NTP Experiment-Test: 88034-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:41:57 __________________________________________________________________________________________________________________________________ | 7| 9| 9| 9| 8| 6| 5| 6| 7| 8| 9| 9| 7| 8| 8| 9| 8| 7| 6| 8| 7| 7| 7| 6| 8| | DAY ON TEST | 2| 1| 1| 1| 7| 2| 9| 1| 6| 5| 1| 1| 8| 8| 8| 1| 7| 5| 2| 1| 6| 9| 2| 1| 5| | | 6| 2| 2| 1| 5| 1| 5| 6| 3| 5| 2| 1| 6| 0| 3| 2| 4| 0| 3| 7| 6| 2| 1| 6| 5| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 | Pheochromocytoma Benign | | 2 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + A + + + +| 47 | __________________________________________________________________________|____________| Parathyroid Gland | + M M + M + M + + + + + M + M M + + + + M + + M M| 28 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + M + + + + + + A + + + +| 48 | Pars Distalis, Adenoma | X X X X | 11 | Pars Distalis, Carcinoma | | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 | Follicular Cell, Adenoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + M + + + + M + + + + + + + + + + + + M M + + +| 44 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + A + I + +| 48 | Cystadenoma | X| 2 | Granulosa Cell Tumor Benign | X | 1 | Luteoma | X| 1 | Lymphoma Malignant | X| 2 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | | 1 | Lymphoma Malignant | X| 3 | Polyp Stromal | | 2 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 | Hemangiosarcoma | | 3 | __________________________________________________________________________|____________| Lymph Node | + + + | 6 | Lymphoma Malignant | | 2 | Iliac, Lymphoma Malignant | X X | 4 | Pancreatic, Lymphoma Malignant | | 1 | Renal, Lymphoma Malignant | X X X | 5 | __________________________________________________________________________|____________| Lymph Node, Bronchial | M + + I + M M M + + + + + + + + + + + + A + M + +| 32 | Hepatocholangiocarcinoma, Metastatic,| | | Liver | | 1 | Lymphoma Malignant | X X X X X| 9 | __________________________________________________________________________|____________| Lymph Node, Mandibular | M + I + + M + + M + + + + M + + + + + + A + + + +| 40 | Lymphoma Malignant | X X X | 6 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 17 NTP Experiment-Test: 88034-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:41:57 __________________________________________________________________________________________________________________________________ | 7| 9| 9| 9| 8| 6| 5| 6| 7| 8| 9| 9| 7| 8| 8| 9| 8| 7| 6| 8| 7| 7| 7| 6| 8| | DAY ON TEST | 2| 1| 1| 1| 7| 2| 9| 1| 6| 5| 1| 1| 8| 8| 8| 1| 7| 5| 2| 1| 6| 9| 2| 1| 5| | | 6| 2| 2| 1| 5| 1| 5| 6| 3| 5| 2| 1| 6| 0| 3| 2| 4| 0| 3| 7| 6| 2| 1| 6| 5| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + A M + + +| 48 | Lymphoma Malignant | X X X X | 9 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + M M + + + M M + + M M + M + + + + + + A + + + +| 36 | Hepatocholangiocarcinoma, Metastatic,| | | Liver | | 1 | Lymphoma Malignant | X X X X X| 9 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | | 3 | Lymphoma Malignant | X X X X | 7 | __________________________________________________________________________|____________| Thymus | + + I + + + + + M M + + + + + M M + M + A + + + M| 35 | Lymphoma Malignant | X X | 6 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma | X| 2 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Schwannoma Malignant | X | 1 | Subcutaneous Tissue, Hemangiosarcoma | X | 2 | Subcutaneous Tissue, Sarcoma | X | 2 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Osteosarcoma | X | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 | Carcinoma, Metastatic, Pituitary | | | Gland | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 | Alveolar/Bronchiolar Adenoma | X X | 3 | Alveolar/Bronchiolar Carcinoma | X X X| 5 | Carcinoma, Metastatic, Harderian | | | Gland | X | 1 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X X X X | 5 | Hepatocholangiocarcinoma, Metastatic,| | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 18 NTP Experiment-Test: 88034-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:41:57 __________________________________________________________________________________________________________________________________ | 7| 9| 9| 9| 8| 6| 5| 6| 7| 8| 9| 9| 7| 8| 8| 9| 8| 7| 6| 8| 7| 7| 7| 6| 8| | DAY ON TEST | 2| 1| 1| 1| 7| 2| 9| 1| 6| 5| 1| 1| 8| 8| 8| 1| 7| 5| 2| 1| 6| 9| 2| 1| 5| | | 6| 2| 2| 1| 5| 1| 5| 6| 3| 5| 2| 1| 6| 0| 3| 2| 4| 0| 3| 7| 6| 2| 1| 6| 5| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Liver | | 1 | Lymphoma Malignant | X X| 4 | Osteosarcoma, Metastatic, Bone | X | 1 | Mediastinum, Hemangiosarcoma | X | 1 | Mediastinum, | | | Hepatocholangiocarcinoma, | | | Metastatic, Liver | | 1 | Mediastinum, Osteosarcoma, | | | Metastatic, Bone | X | 1 | Mediastinum, Sarcoma, Metastatic, | | | Skin | | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | + | 1 | __________________________________________________________________________|____________| Harderian Gland | + + + | 5 | Adenoma | X X | 4 | Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 | Hepatocholangiocarcinoma, Metastatic,| | | Liver | | 1 | Lymphoma Malignant | X | 4 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 | Lymphoma Malignant | X| 3 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X X X X X X X| 12 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 19 NTP Experiment-Test: 88034-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:41:57 _____________________________________________________________________________________________________________________ | 7| 7| 6| 8| 8| 8| 5| 9| 6| 9| 6| 7| 9| 5| 9| 5| 6| 7| 8| 6| 6| 7| 7| 7| 8| DAY ON TEST | 4| 8| 9| 5| 7| 6| 8| 0| 6| 1| 9| 3| 1| 5| 1| 8| 5| 7| 4| 7| 6| 2| 6| 4| 3| | 1| 6| 6| 5| 4| 9| 8| 3| 0| 1| 7| 5| 1| 9| 2| 6| 1| 4| 7| 8| 5| 2| 7| 9| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | A + + + + + + + I + + + + + + + + A + + + + A + +| Histiocytic Sarcoma | | __________________________________________________________________________| Intestine Large, Colon | A + + + + + + M + + + + + + + + + A + + + + A + +| __________________________________________________________________________| Intestine Large, Rectum | A + + + + + + + + + + + + + + + + A + + + + A + +| __________________________________________________________________________| Intestine Large, Cecum | A + + + + + + + A + + + + + + + + A + + + + + + +| Leiomyosarcoma | X | __________________________________________________________________________| Intestine Small, Duodenum | A + + + + + + + A + + + + + + + + M + + + + A + +| Lymphoma Malignant | X | Peyer's Patch, Histiocytic Sarcoma | | __________________________________________________________________________| Intestine Small, Jejunum | A + + + + + + + + + + + + + + + + A + + + + A + +| Peyer's Patch, Lymphoma Malignant | X | __________________________________________________________________________| Intestine Small, Ileum | A + + + + + + + A + + + + + + + + A + + + + A + +| Lymphoma Malignant | X | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Hepatocellular Carcinoma | X X X X | Hepatocellular Carcinoma, Multiple | | Hepatocellular Adenoma | X X X X X| Hepatocellular Adenoma, Multiple | X X | Histiocytic Sarcoma | | Lymphoma Malignant | X X X| __________________________________________________________________________| Mesentery | + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant | X X X X| __________________________________________________________________________| Oral Mucosa | + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X X X| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | __________________________________________________________________________| Stomach, Forestomach | + + M + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X| __________________________________________________________________________| Stomach, Glandular | + + M + + + + + + + + + + + + + + A + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant | X X X| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Histiocytic Sarcoma | | _____________________________________________________________________________________________________________________| Page 20 NTP Experiment-Test: 88034-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:41:57 _____________________________________________________________________________________________________________________ | 7| 7| 6| 8| 8| 8| 5| 9| 6| 9| 6| 7| 9| 5| 9| 5| 6| 7| 8| 6| 6| 7| 7| 7| 8| DAY ON TEST | 4| 8| 9| 5| 7| 6| 8| 0| 6| 1| 9| 3| 1| 5| 1| 8| 5| 7| 4| 7| 6| 2| 6| 4| 3| | 1| 6| 6| 5| 4| 9| 8| 3| 0| 1| 7| 5| 1| 9| 2| 6| 1| 4| 7| 8| 5| 2| 7| 9| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Malignant | | Pheochromocytoma Benign | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + M + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | M + + M + + + + M + M + M + + M M + + + + M + M M| __________________________________________________________________________| Pituitary Gland | + + + + + I + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X X| Pars Intermedia, Adenoma | X X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | M M + + + + + + + + + + + + + + + + I + M + + M M| __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cystadenoma | | Hemangioma | X X | Histiocytic Sarcoma | X | Luteoma | | Lymphoma Malignant | X X X| __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangioma | X | Histiocytic Sarcoma | | Leiomyoma | | Lymphoma Malignant | X X| Polyp Stromal | X X X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Histiocytic Sarcoma | X | Lymphoma Malignant | | __________________________________________________________________________| Lymph Node | + + + + | Lymphoma Malignant | X | Iliac, Lymphoma Malignant | X X X | Pancreatic, Lymphoma Malignant | X | Renal, Histiocytic Sarcoma | | Renal, Lymphoma Malignant | X X X | __________________________________________________________________________| Lymph Node, Bronchial | M M + + M M + M + + + M M + + M M + + + M M M M +| Histiocytic Sarcoma | | Lymphoma Malignant | X X X X| __________________________________________________________________________| Lymph Node, Mandibular | M + + + + + + M + + + + M M + M + + + M + M + + +| _____________________________________________________________________________________________________________________| Page 21 NTP Experiment-Test: 88034-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:41:57 _____________________________________________________________________________________________________________________ | 7| 7| 6| 8| 8| 8| 5| 9| 6| 9| 6| 7| 9| 5| 9| 5| 6| 7| 8| 6| 6| 7| 7| 7| 8| DAY ON TEST | 4| 8| 9| 5| 7| 6| 8| 0| 6| 1| 9| 3| 1| 5| 1| 8| 5| 7| 4| 7| 6| 2| 6| 4| 3| | 1| 6| 6| 5| 4| 9| 8| 3| 0| 1| 7| 5| 1| 9| 2| 6| 1| 4| 7| 8| 5| 2| 7| 9| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Lymphoma Malignant | X X X X X| __________________________________________________________________________| Lymph Node, Mesenteric | + M + + + + + M + + + + + + M + + + + + + + A + +| Histiocytic Sarcoma | | Lymphoma Malignant | X X X X X| __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + M + M + + M + + + + + + M M + + M +| Histiocytic Sarcoma | | Lymphoma Malignant | X X X X| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Histiocytic Sarcoma | | Lymphoma Malignant | X X| __________________________________________________________________________| Thymus | M M + M M + + M + + + + M + M M + + M + M + + + +| Lymphoma Malignant | X X X X| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X X | Carcinoma, Multiple | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Histiocytic | | Sarcoma | | Subcutaneous Tissue, Sarcoma | X X | Subcutaneous Tissue, Sarcoma, | | Multiple | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | __________________________________________________________________________| Skeletal Muscle | | Histiocytic Sarcoma | | Rhabdomyosarcoma | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X X X X X | Alveolar/Bronchiolar Adenoma, | | Multiple | X | Alveolar/Bronchiolar Carcinoma | X | Hepatocellular Carcinoma, Metastatic,| | Liver | X | _____________________________________________________________________________________________________________________| Page 22 NTP Experiment-Test: 88034-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:41:57 _____________________________________________________________________________________________________________________ | 7| 7| 6| 8| 8| 8| 5| 9| 6| 9| 6| 7| 9| 5| 9| 5| 6| 7| 8| 6| 6| 7| 7| 7| 8| DAY ON TEST | 4| 8| 9| 5| 7| 6| 8| 0| 6| 1| 9| 3| 1| 5| 1| 8| 5| 7| 4| 7| 6| 2| 6| 4| 3| | 1| 6| 6| 5| 4| 9| 8| 3| 0| 1| 7| 5| 1| 9| 2| 6| 1| 4| 7| 8| 5| 2| 7| 9| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Histiocytic Sarcoma | X | Lymphoma Malignant | X X X X X| Sarcoma, Metastatic, Skin | X | Mediastinum, Lymphoma Malignant | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | + | Adenoma | | Carcinoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant | X X | __________________________________________________________________________| Urinary Bladder | A + + + + + + + + + + + + + + + + A + + + + A + +| Lymphoma Malignant | X| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Lymphoma Malignant | X X X X X X X| _____________________________________________________________________________________________________________________| Page 23 NTP Experiment-Test: 88034-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:41:57 __________________________________________________________________________________________________________________________________ | 9| 7| 7| 8| 9| 4| 9| 7| 8| 6| 8| 8| 4| 8| 9| 7| 6| 9| 9| 9| 8| 5| 6| 6| 9| | DAY ON TEST | 1| 7| 4| 5| 0| 5| 1| 0| 7| 8| 3| 8| 1| 4| 1| 5| 4| 1| 1| 1| 6| 3| 4| 9| 1| | | 1| 8| 9| 2| 3| 5| 2| 3| 4| 0| 3| 0| 6| 7| 2| 5| 7| 1| 2| 1| 9| 0| 6| 3| 2| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + + + M + + + + + + A + + +| 44 | Histiocytic Sarcoma | X | 1 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Leiomyosarcoma | | 1 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 | Lymphoma Malignant | | 1 | Peyer's Patch, Histiocytic Sarcoma | X | 1 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Peyer's Patch, Lymphoma Malignant | | 1 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 | Lymphoma Malignant | | 1 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | X | 2 | Hepatocellular Carcinoma | X X | 6 | Hepatocellular Carcinoma, Multiple | X X | 2 | Hepatocellular Adenoma | X X X X | 9 | Hepatocellular Adenoma, Multiple | X X| 4 | Histiocytic Sarcoma | X X | 2 | Lymphoma Malignant | X X X X X | 8 | __________________________________________________________________________|____________| Mesentery | + + + | 10 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant | X | 5 | __________________________________________________________________________|____________| Oral Mucosa | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 | Lymphoma Malignant | X X X | 6 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 | Lymphoma Malignant | X X | 3 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Lymphoma Malignant | X | 2 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant | X | 4 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 24 NTP Experiment-Test: 88034-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:41:57 __________________________________________________________________________________________________________________________________ | 9| 7| 7| 8| 9| 4| 9| 7| 8| 6| 8| 8| 4| 8| 9| 7| 6| 9| 9| 9| 8| 5| 6| 6| 9| | DAY ON TEST | 1| 7| 4| 5| 0| 5| 1| 0| 7| 8| 3| 8| 1| 4| 1| 5| 4| 1| 1| 1| 6| 3| 4| 9| 1| | | 1| 8| 9| 2| 3| 5| 2| 3| 4| 0| 3| 0| 6| 7| 2| 5| 7| 1| 2| 1| 9| 0| 6| 3| 2| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | | 1 | Histiocytic Sarcoma | X | 1 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pheochromocytoma Malignant | X | 1 | Pheochromocytoma Benign | X | 1 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + M + + + + + + + +| 48 | __________________________________________________________________________|____________| Parathyroid Gland | M M + M + + + M M M + M + + + + + M + I + + M M +| 29 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Pars Distalis, Adenoma | X X X X X X X| 12 | Pars Intermedia, Adenoma | | 3 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Follicular Cell, Adenoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + M + + + + + + + + + M + + + + + + +| 42 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cystadenoma | X X| 2 | Hemangioma | | 2 | Histiocytic Sarcoma | X | 2 | Luteoma | X | 1 | Lymphoma Malignant | X X X | 6 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangioma | X | 2 | Histiocytic Sarcoma | X | 1 | Leiomyoma | X | 1 | Lymphoma Malignant | X X | 4 | Polyp Stromal | X X | 6 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | X | 1 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant | X X | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 25 NTP Experiment-Test: 88034-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:41:57 __________________________________________________________________________________________________________________________________ | 9| 7| 7| 8| 9| 4| 9| 7| 8| 6| 8| 8| 4| 8| 9| 7| 6| 9| 9| 9| 8| 5| 6| 6| 9| | DAY ON TEST | 1| 7| 4| 5| 0| 5| 1| 0| 7| 8| 3| 8| 1| 4| 1| 5| 4| 1| 1| 1| 6| 3| 4| 9| 1| | | 1| 8| 9| 2| 3| 5| 2| 3| 4| 0| 3| 0| 6| 7| 2| 5| 7| 1| 2| 1| 9| 0| 6| 3| 2| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lymph Node | + + + + + | 9 | Lymphoma Malignant | X X | 3 | Iliac, Lymphoma Malignant | X X X | 6 | Pancreatic, Lymphoma Malignant | | 1 | Renal, Histiocytic Sarcoma | X | 1 | Renal, Lymphoma Malignant | X X | 5 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + + + + + + M + M + + + M + + + + + + + M +| 33 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant | X X X X | 8 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + I + + + + + + + + + + + + + + + + + + M +| 41 | Lymphoma Malignant | X X X X | 9 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + M M + + + + + + + + + + + + + + + + + + +| 44 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant | X X X | 8 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | M + + + M M + + M + + + M + + M + + + + + + + + +| 38 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant | X X X X X | 9 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | X X | 3 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant | X X X X | 6 | __________________________________________________________________________|____________| Thymus | M + + + M + M + M M + M + + + M + + + + + + + + +| 33 | Lymphoma Malignant | X X X X | 8 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma | | 2 | Carcinoma, Multiple | X | 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Subcutaneous Tissue, Histiocytic | | | Sarcoma | X | 1 | Subcutaneous Tissue, Sarcoma | X X X | 5 | Subcutaneous Tissue, Sarcoma, | | | Multiple | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | X | 1 | __________________________________________________________________________|____________| Skeletal Muscle | + + | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 26 NTP Experiment-Test: 88034-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:41:57 __________________________________________________________________________________________________________________________________ | 9| 7| 7| 8| 9| 4| 9| 7| 8| 6| 8| 8| 4| 8| 9| 7| 6| 9| 9| 9| 8| 5| 6| 6| 9| | DAY ON TEST | 1| 7| 4| 5| 0| 5| 1| 0| 7| 8| 3| 8| 1| 4| 1| 5| 4| 1| 1| 1| 6| 3| 4| 9| 1| | | 1| 8| 9| 2| 3| 5| 2| 3| 4| 0| 3| 0| 6| 7| 2| 5| 7| 1| 2| 1| 9| 0| 6| 3| 2| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM - cont | | | | | | Histiocytic Sarcoma | X | 1 | Rhabdomyosarcoma | X | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X X X X | 10 | Alveolar/Bronchiolar Adenoma, | | | Multiple | | 1 | Alveolar/Bronchiolar Carcinoma | X | 2 | Hepatocellular Carcinoma, Metastatic,| | | Liver | | 1 | Histiocytic Sarcoma | X | 2 | Lymphoma Malignant | X X X X X X | 11 | Sarcoma, Metastatic, Skin | | 1 | Mediastinum, Lymphoma Malignant | X | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X | 1 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Harderian Gland | + + | 3 | Adenoma | X X | 2 | Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant | X X X X | 6 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + I + + + + + + + + + + + +| 46 | Lymphoma Malignant | X X X | 4 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | X X | 3 | Lymphoma Malignant | X X X X X X | 13 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 27 NTP Experiment-Test: 88034-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:41:57 _____________________________________________________________________________________________________________________ | 9| 7| 8| 7| 7| 4| 8| 5| 8| 8| 3| 8| 7| 4| 9| 9| 9| 0| 9| 8| 9| 7| 6| 6| 8| DAY ON TEST | 1| 8| 8| 7| 0| 5| 0| 7| 0| 0| 9| 0| 6| 8| 1| 0| 1| 9| 1| 4| 1| 4| 9| 9| 4| | 2| 1| 3| 8| 1| 4| 7| 8| 7| 5| 1| 7| 7| 2| 1| 1| 2| 5| 2| 5| 1| 9| 3| 4| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + A + + + + + + +| __________________________________________________________________________| Gallbladder | + A + + + + + A + + A + + + + + + A M + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + A + + + + + A + + + + + + + + + A + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + A + + + + + A + + + + + + + + + A + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + A + + + + + A + + + + + + + + + A + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + A + + + + + A + + + + + + + + + A + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + A + + + + + A + + + + + + + + + A + + + + + A +| Carcinoma | | __________________________________________________________________________| Intestine Small, Ileum | + A + + + + + M + + + + + + + + + A + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + A + + + + + + +| Cholangiocarcinoma | X | Hepatocellular Carcinoma | X X | Hepatocellular Carcinoma, Multiple | X X X X X X| Hepatocellular Adenoma | X | Hepatocellular Adenoma, Multiple | X X X | Histiocytic Sarcoma | X | Lymphoma Malignant | X | Sarcoma, Metastatic, Seminal Vesicle | X | Squamous Cell Carcinoma, Metastatic, | | Uncertain Primary Site | | Squamous Cell Carcinoma, Metastatic, | | Stomach, Forestomach | X | __________________________________________________________________________| Mesentery | + + | Sarcoma, Metastatic, Seminal Vesicle | X | Squamous Cell Carcinoma, Metastatic, | | Stomach, Forestomach | X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + M + + + + + + +| Squamous Cell Carcinoma, Metastatic, | | Stomach, Forestomach | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + A + + + + + + +| Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | X | Carcinoma | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + A + + + + + + +| Sarcoma, Metastatic, Seminal Vesicle | X | Squamous Cell Carcinoma | X | Squamous Cell Papilloma | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + A + + + + + + +| Sarcoma, Metastatic, Seminal Vesicle | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | X | _____________________________________________________________________________________________________________________| Page 28 NTP Experiment-Test: 88034-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:41:57 _____________________________________________________________________________________________________________________ | 9| 7| 8| 7| 7| 4| 8| 5| 8| 8| 3| 8| 7| 4| 9| 9| 9| 0| 9| 8| 9| 7| 6| 6| 8| DAY ON TEST | 1| 8| 8| 7| 0| 5| 0| 7| 0| 0| 9| 0| 6| 8| 1| 0| 1| 9| 1| 4| 1| 4| 9| 9| 4| | 2| 1| 3| 8| 1| 4| 7| 8| 7| 5| 1| 7| 7| 2| 1| 1| 2| 5| 2| 5| 1| 9| 3| 4| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + A + + + + + + + + + A I + + + + + +| Adenoma | X | Sarcoma, Metastatic, Seminal Vesicle | X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + A + + + + + + + + + A + + + + + + +| Pheochromocytoma Benign | X | Sarcoma, Metastatic, Seminal Vesicle | X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + M + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + M + + A + M + + + + +| __________________________________________________________________________| Pituitary Gland | + M + + + + + + + + + + + + + + + A + I + + + + +| Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | X | Pars Intermedia, Adenoma | X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + A + + + + + + +| Follicular Cell, Adenoma | | Follicular Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + A + + + + + + +| Histiocytic Sarcoma | X | __________________________________________________________________________| Penis | + + | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + A + + + + + + +| Histiocytic Sarcoma | X | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + A + + + + + M +| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + A + + + + + + +| Sarcoma | X | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Interstitial Cell, Adenoma | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + A + + + + + + +| Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | X | Hemangiosarcoma | | Histiocytic Sarcoma | X | __________________________________________________________________________| Lymph Node | + + | Iliac, Lymphoma Malignant | X | Renal, Lymphoma Malignant | X | __________________________________________________________________________| Lymph Node, Bronchial | + M + M M + + + M M + + + + M M + A + M M M M + +| _____________________________________________________________________________________________________________________| Page 29 NTP Experiment-Test: 88034-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:41:57 _____________________________________________________________________________________________________________________ | 9| 7| 8| 7| 7| 4| 8| 5| 8| 8| 3| 8| 7| 4| 9| 9| 9| 0| 9| 8| 9| 7| 6| 6| 8| DAY ON TEST | 1| 8| 8| 7| 0| 5| 0| 7| 0| 0| 9| 0| 6| 8| 1| 0| 1| 9| 1| 4| 1| 4| 9| 9| 4| | 2| 1| 3| 8| 1| 4| 7| 8| 7| 5| 1| 7| 7| 2| 1| 1| 2| 5| 2| 5| 1| 9| 3| 4| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Lymphoma Malignant | X | __________________________________________________________________________| Lymph Node, Mandibular | M M M M + + + + + I + + + M + + + M + + + + M + M| Lymphoma Malignant | X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + A + + + + + + +| Lymphoma Malignant | X | __________________________________________________________________________| Lymph Node, Mediastinal | + + M + + + + + + + M M + + + + + A + + + M + + +| Lymphoma Malignant | X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + M + + + + + + +| Hemangiosarcoma | | Lymphoma Malignant | X | __________________________________________________________________________| Thymus | + + M + + M M + M + + M + + M M + A + M + + + M M| Lymphoma Malignant | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + A + + + + + + +| Subcutaneous Tissue, Hemangiosarcoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + + | Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | X | Sarcoma, Metastatic, Seminal Vesicle | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + A + + + + + + +| Choristoma | X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + A + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + A + + + + + + +| Alveolar/Bronchiolar Adenoma | X X X | Alveolar/Bronchiolar Adenoma, | | Multiple | | Alveolar/Bronchiolar Carcinoma | X X| Alveolar/Bronchiolar Carcinoma, | | Multiple | X | Carcinoma, Metastatic, Salivary | | Glands | | Hepatocellular Carcinoma, Metastatic,| | Liver | X | Mediastinum, Alveolar/Bronchiolar | | Carcinoma, Metastatic, Lung | X | _____________________________________________________________________________________________________________________| Page 30 NTP Experiment-Test: 88034-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:41:57 _____________________________________________________________________________________________________________________ | 9| 7| 8| 7| 7| 4| 8| 5| 8| 8| 3| 8| 7| 4| 9| 9| 9| 0| 9| 8| 9| 7| 6| 6| 8| DAY ON TEST | 1| 8| 8| 7| 0| 5| 0| 7| 0| 0| 9| 0| 6| 8| 1| 0| 1| 9| 1| 4| 1| 4| 9| 9| 4| | 2| 1| 3| 8| 1| 4| 7| 8| 7| 5| 1| 7| 7| 2| 1| 1| 2| 5| 2| 5| 1| 9| 3| 4| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + A + + + + + + +| Histiocytic Sarcoma | X | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + A + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | __________________________________________________________________________| Harderian Gland | + + + + + | Adenoma | X X X X | __________________________________________________________________________| Lacrimal Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + A + + + + + + +| Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | X | Histiocytic Sarcoma | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + A + + + + M + + + + A + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Lymphoma Malignant | X | _____________________________________________________________________________________________________________________| Page 31 NTP Experiment-Test: 88034-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:41:57 __________________________________________________________________________________________________________________________________ | 5| 3| 9| 3| 9| 8| 9| 8| 8| 9| 9| 6| 7| 8| 7| 9| 7| 7| 9| 9| 6| 8| 3| 9| 9| | DAY ON TEST | 2| 8| 1| 2| 1| 8| 1| 4| 1| 1| 1| 0| 2| 1| 9| 1| 0| 2| 1| 1| 6| 6| 9| 1| 0| | | 7| 7| 2| 8| 1| 2| 1| 0| 7| 1| 2| 5| 1| 0| 1| 1| 7| 2| 2| 1| 5| 9| 2| 1| 3| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + M A + + + + + + + + + + + + + + + +| 43 | __________________________________________________________________________|____________| Intestine Large, Colon | + A + A + + + + + + + + + + + + + + + + + + + + +| 45 | __________________________________________________________________________|____________| Intestine Large, Rectum | + A + + + + + + + + + + + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Intestine Large, Cecum | + A + A + + + + A + + + + + + + + + + + + + + + +| 44 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + A + A + + + + A + + + + + + + + + + + + + + + +| 44 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + A + A + + + + A + + + + + + + + + + + + + + + +| 43 | Carcinoma | X | 1 | __________________________________________________________________________|____________| Intestine Small, Ileum | + A + A + + + + A + + + + + + + + + + + + + + + +| 44 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Cholangiocarcinoma | | 1 | Hepatocellular Carcinoma | X X X X X| 7 | Hepatocellular Carcinoma, Multiple | X X X X X X X | 13 | Hepatocellular Adenoma | X X X X X | 6 | Hepatocellular Adenoma, Multiple | X X X X| 7 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant | | 1 | Sarcoma, Metastatic, Seminal Vesicle | | 1 | Squamous Cell Carcinoma, Metastatic, | | | Uncertain Primary Site | X | 1 | Squamous Cell Carcinoma, Metastatic, | | | Stomach, Forestomach | | 1 | __________________________________________________________________________|____________| Mesentery | + | 3 | Sarcoma, Metastatic, Seminal Vesicle | | 1 | Squamous Cell Carcinoma, Metastatic, | | | Stomach, Forestomach | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Squamous Cell Carcinoma, Metastatic, | | | Stomach, Forestomach | | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Alveolar/Bronchiolar Carcinoma, | | | Metastatic, Lung | | 1 | Carcinoma | X | 1 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Sarcoma, Metastatic, Seminal Vesicle | | 1 | Squamous Cell Carcinoma | | 1 | Squamous Cell Papilloma | X X | 2 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Sarcoma, Metastatic, Seminal Vesicle | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 32 NTP Experiment-Test: 88034-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:41:57 __________________________________________________________________________________________________________________________________ | 5| 3| 9| 3| 9| 8| 9| 8| 8| 9| 9| 6| 7| 8| 7| 9| 7| 7| 9| 9| 6| 8| 3| 9| 9| | DAY ON TEST | 2| 8| 1| 2| 1| 8| 1| 4| 1| 1| 1| 0| 2| 1| 9| 1| 0| 2| 1| 1| 6| 6| 9| 1| 0| | | 7| 7| 2| 8| 1| 2| 1| 0| 7| 1| 2| 5| 1| 0| 1| 1| 7| 2| 2| 1| 5| 9| 2| 1| 3| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Carcinoma, | | | Metastatic, Lung | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Adenoma | X| 2 | Sarcoma, Metastatic, Seminal Vesicle | | 1 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Pheochromocytoma Benign | | 1 | Sarcoma, Metastatic, Seminal Vesicle | | 1 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + M + M + + + + + + + M + + + + M +| 43 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Alveolar/Bronchiolar Carcinoma, | | | Metastatic, Lung | | 1 | Pars Intermedia, Adenoma | X | 2 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Follicular Cell, Adenoma | X| 1 | Follicular Cell, Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Histiocytic Sarcoma | | 1 | __________________________________________________________________________|____________| Penis | + + | 4 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Histiocytic Sarcoma | | 1 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + M + + + + + + + + + +| 48 | Sarcoma | | 1 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 1 | Interstitial Cell, Adenoma | X X | 2 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 33 NTP Experiment-Test: 88034-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:41:57 __________________________________________________________________________________________________________________________________ | 5| 3| 9| 3| 9| 8| 9| 8| 8| 9| 9| 6| 7| 8| 7| 9| 7| 7| 9| 9| 6| 8| 3| 9| 9| | DAY ON TEST | 2| 8| 1| 2| 1| 8| 1| 4| 1| 1| 1| 0| 2| 1| 9| 1| 0| 2| 1| 1| 6| 6| 9| 1| 0| | | 7| 7| 2| 8| 1| 2| 1| 0| 7| 1| 2| 5| 1| 0| 1| 1| 7| 2| 2| 1| 5| 9| 2| 1| 3| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Alveolar/Bronchiolar Carcinoma, | | | Metastatic, Lung | | 1 | Hemangiosarcoma | X | 1 | Histiocytic Sarcoma | | 1 | __________________________________________________________________________|____________| Lymph Node | | 2 | Iliac, Lymphoma Malignant | | 1 | Renal, Lymphoma Malignant | | 1 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + M + + M M + + + + M M + M M + + M M M + + M M| 26 | Lymphoma Malignant | | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + M + M M + M + + + + + + + M + M + M + +| 34 | Lymphoma Malignant | | 1 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + M + + + + + + + + + + + + + + + + + + + + +| 48 | Lymphoma Malignant | X | 2 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + M + M M + + + + + M + M + + + + + + + M + M + M| 37 | Lymphoma Malignant | | 1 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hemangiosarcoma | X | 1 | Lymphoma Malignant | | 1 | __________________________________________________________________________|____________| Thymus | + + + + + M M M + M + M + + + I + M M + + M + + M| 29 | Lymphoma Malignant | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Subcutaneous Tissue, Hemangiosarcoma | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Skeletal Muscle | | 2 | Alveolar/Bronchiolar Carcinoma, | | | Metastatic, Lung | | 1 | Sarcoma, Metastatic, Seminal Vesicle | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Choristoma | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 34 NTP Experiment-Test: 88034-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:41:57 __________________________________________________________________________________________________________________________________ | 5| 3| 9| 3| 9| 8| 9| 8| 8| 9| 9| 6| 7| 8| 7| 9| 7| 7| 9| 9| 6| 8| 3| 9| 9| | DAY ON TEST | 2| 8| 1| 2| 1| 8| 1| 4| 1| 1| 1| 0| 2| 1| 9| 1| 0| 2| 1| 1| 6| 6| 9| 1| 0| | | 7| 7| 2| 8| 1| 2| 1| 0| 7| 1| 2| 5| 1| 0| 1| 1| 7| 2| 2| 1| 5| 9| 2| 1| 3| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Alveolar/Bronchiolar Adenoma | X X X X | 7 | Alveolar/Bronchiolar Adenoma, | | | Multiple | X | 1 | Alveolar/Bronchiolar Carcinoma | X X X X| 6 | Alveolar/Bronchiolar Carcinoma, | | | Multiple | X | 2 | Carcinoma, Metastatic, Salivary | | | Glands | X | 1 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X X X X X | 6 | Mediastinum, Alveolar/Bronchiolar | | | Carcinoma, Metastatic, Lung | | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Histiocytic Sarcoma | | 1 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + + | 3 | __________________________________________________________________________|____________| Harderian Gland | + + | 7 | Adenoma | X X | 6 | __________________________________________________________________________|____________| Lacrimal Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Alveolar/Bronchiolar Carcinoma, | | | Metastatic, Lung | | 1 | Histiocytic Sarcoma | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant | X | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 35 NTP Experiment-Test: 88034-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:41:57 _____________________________________________________________________________________________________________________ | 9| 7| 8| 6| 9| 6| 6| 6| 4| 9| 8| 9| 9| 8| 5| 7| 7| 6| 7| 7| 9| 7| 9| 6| 9| DAY ON TEST | 1| 9| 6| 9| 1| 1| 9| 5| 7| 1| 2| 1| 1| 0| 6| 9| 0| 3| 7| 2| 1| 2| 0| 7| 1| | 2| 8| 9| 3| 1| 0| 3| 1| 1| 1| 3| 1| 2| 4| 8| 9| 9| 2| 3| 1| 2| 2| 1| 8| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + A + + + + M + + + + + + + + A + + + A +| __________________________________________________________________________| Intestine Large, Colon | + + + + + A + + + + + + + + + + + + + A + + + A +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + A +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + A + + + + + + + + + + + + + A + + + A +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + A + + + + + + + + + + + + + A + + + A +| Lymphoma Malignant | X| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + A + + + + + + + + + + + A + A + + + A +| Carcinoma | | Lymphoma Malignant | X X| __________________________________________________________________________| Intestine Small, Ileum | + + + + + A + + + + + + + + + + + + + A + + + A +| Lymphoma Malignant | X| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Hepatocellular Carcinoma | X X X X X X | Hepatocellular Carcinoma, Multiple | X | Hepatocellular Adenoma | X X X X X X X | Hepatocellular Adenoma, Multiple | X X | Histiocytic Sarcoma | X | Lymphoma Malignant | | __________________________________________________________________________| Mesentery | + + +| Hemangioma | X| Hemangiosarcoma | X | __________________________________________________________________________| Oral Mucosa | + | Pharyngeal, Squamous Cell Carcinoma | X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + A +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + A +| Lymphoma Malignant | X| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + A +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + A + + + A +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + A +| Adenoma | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + M + + + + + + + + A +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + A +| Adenoma | X | __________________________________________________________________________| Parathyroid Gland | M M M M M + + + M + + + M + + + + + + M + + M M +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + M + + + + +| Pars Distalis, Adenoma | X | _____________________________________________________________________________________________________________________| Page 36 NTP Experiment-Test: 88034-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:41:57 _____________________________________________________________________________________________________________________ | 9| 7| 8| 6| 9| 6| 6| 6| 4| 9| 8| 9| 9| 8| 5| 7| 7| 6| 7| 7| 9| 7| 9| 6| 9| DAY ON TEST | 1| 9| 6| 9| 1| 1| 9| 5| 7| 1| 2| 1| 1| 0| 6| 9| 0| 3| 7| 2| 1| 2| 0| 7| 1| | 2| 8| 9| 3| 1| 0| 3| 1| 1| 1| 3| 1| 2| 4| 8| 9| 9| 2| 3| 1| 2| 2| 1| 8| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Thyroid Gland | + + + + + + I + + + + + + + + + + + + + + + + A +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + A +| Histiocytic Sarcoma | X | Sarcoma | | __________________________________________________________________________| Penis | + + | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + A +| Sarcoma | X | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + M + + + + + + + + + A +| Lymphoma Malignant | | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + A +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + A +| Interstitial Cell, Adenoma | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + A +| Hemangiosarcoma | | Lymphoma Malignant | | __________________________________________________________________________| Lymph Node | +| Iliac, Lymphoma Malignant | X| Pancreatic, Lymphoma Malignant | | Renal, Lymphoma Malignant | X| __________________________________________________________________________| Lymph Node, Bronchial | M + + + M M M M + + M + M + + M + + + + M M M M +| Lymphoma Malignant | X| __________________________________________________________________________| Lymph Node, Mandibular | M + + M + + M I + M + M + + M + M + M + + + + M +| Lymphoma Malignant | X| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + M + + + + + + + + + M + + + + + M +| Histiocytic Sarcoma | X | Lymphoma Malignant | X X| __________________________________________________________________________| Lymph Node, Mediastinal | + + + + M + + M + + I + + M + M + + M + + + + A +| Lymphoma Malignant | X| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + A +| Hemangiosarcoma | X | Lymphoma Malignant | X| __________________________________________________________________________| Thymus | + M M + M + + + + + + + M M M + + M M + + M M A +| Lymphoma Malignant | X| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 37 NTP Experiment-Test: 88034-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:41:57 _____________________________________________________________________________________________________________________ | 9| 7| 8| 6| 9| 6| 6| 6| 4| 9| 8| 9| 9| 8| 5| 7| 7| 6| 7| 7| 9| 7| 9| 6| 9| DAY ON TEST | 1| 9| 6| 9| 1| 1| 9| 5| 7| 1| 2| 1| 1| 0| 6| 9| 0| 3| 7| 2| 1| 2| 0| 7| 1| | 2| 8| 9| 3| 1| 0| 3| 1| 1| 1| 3| 1| 2| 4| 8| 9| 9| 2| 3| 1| 2| 2| 1| 8| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Subcutaneous Tissue, Hemangiosarcoma | X | Subcutaneous Tissue, Sarcoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + A +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + A +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + A +| Alveolar/Bronchiolar Adenoma | X X X X | Alveolar/Bronchiolar Carcinoma | X X X X | Alveolar/Bronchiolar Carcinoma, | | Multiple | X | Carcinoma, Metastatic, Harderian | | Gland | X | Hepatocellular Carcinoma, Metastatic,| | Liver | X X | Histiocytic Sarcoma | X | Lymphoma Malignant | | Mediastinum, Alveolar/Bronchiolar | | Carcinoma, Metastatic, Lung | X | Mediastinum, Hemangioma | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + A +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + A +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | __________________________________________________________________________| Harderian Gland | + + + | Adenoma | X | Carcinoma | X | __________________________________________________________________________| Zymbal's Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + A +| Histiocytic Sarcoma | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + A +| Lymphoma Malignant | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Lymphoma Malignant | X X| _____________________________________________________________________________________________________________________| Page 38 NTP Experiment-Test: 88034-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:41:57 __________________________________________________________________________________________________________________________________ | 7| 3| 6| 7| 6| 8| 7| 9| 8| 8| 9| 4| 7| 8| 8| 7| 8| 8| 8| 9| 9| 8| 7| 7| 6| | DAY ON TEST | 1| 8| 7| 9| 4| 4| 3| 1| 4| 4| 1| 4| 0| 2| 1| 3| 0| 8| 7| 1| 1| 3| 8| 2| 1| | | 6| 6| 8| 1| 9| 7| 5| 1| 5| 7| 2| 6| 7| 6| 2| 5| 5| 0| 5| 1| 2| 8| 7| 1| 6| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | + + A + + + + + + + + + + + + + + + + + + A + + +| 44 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + A + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + A + + + + + + + + + + + + + + + + + + A + + +| 45 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + A + + + + + + + + + + + + + + + + + + A + + +| 45 | Lymphoma Malignant | X | 2 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + A + + + + + + + + + + + + + + + + + + A + + +| 44 | Carcinoma | X | 1 | Lymphoma Malignant | | 2 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + A + + + + + + + + + + + + + + + + + + A + + +| 45 | Lymphoma Malignant | X | 2 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | | 1 | Hepatocellular Carcinoma | X X X X X X X X | 14 | Hepatocellular Carcinoma, Multiple | X X | 3 | Hepatocellular Adenoma | X X X X X| 12 | Hepatocellular Adenoma, Multiple | X X X X | 6 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant | X | 1 | __________________________________________________________________________|____________| Mesentery | | 3 | Hemangioma | | 1 | Hemangiosarcoma | | 1 | __________________________________________________________________________|____________| Oral Mucosa | | 1 | Pharyngeal, Squamous Cell Carcinoma | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Lymphoma Malignant | | 1 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Stomach, Glandular | + + A + + + + + + + + + + + + + + + + + + + + + +| 47 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Adenoma | X | 1 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 39 NTP Experiment-Test: 88034-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:41:57 __________________________________________________________________________________________________________________________________ | 7| 3| 6| 7| 6| 8| 7| 9| 8| 8| 9| 4| 7| 8| 8| 7| 8| 8| 8| 9| 9| 8| 7| 7| 6| | DAY ON TEST | 1| 8| 7| 9| 4| 4| 3| 1| 4| 4| 1| 4| 0| 2| 1| 3| 0| 8| 7| 1| 1| 3| 8| 2| 1| | | 6| 6| 8| 1| 9| 7| 5| 1| 5| 7| 2| 6| 7| 6| 2| 5| 5| 0| 5| 1| 2| 8| 7| 1| 6| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Adenoma | | 1 | __________________________________________________________________________|____________| Parathyroid Gland | + + M + + M + M M + + + + + + + + + M M + M + M +| 32 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Pars Distalis, Adenoma | | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Histiocytic Sarcoma | | 1 | Sarcoma | X | 1 | __________________________________________________________________________|____________| Penis | | 2 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Sarcoma | | 1 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + M + + + + + + +| 47 | Lymphoma Malignant | X | 1 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Interstitial Cell, Adenoma | X | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hemangiosarcoma | X X | 2 | Lymphoma Malignant | X | 1 | __________________________________________________________________________|____________| Lymph Node | + + | 3 | Iliac, Lymphoma Malignant | X | 2 | Pancreatic, Lymphoma Malignant | X | 1 | Renal, Lymphoma Malignant | X | 2 | __________________________________________________________________________|____________| Lymph Node, Bronchial | M + + + M + M M M + M + M + M + + M + + + M + M +| 27 | Lymphoma Malignant | X | 2 | __________________________________________________________________________|____________| Lymph Node, Mandibular | M + + M + + + + + M + + + M + M M M + M M + + + +| 31 | Lymphoma Malignant | X | 2 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + M + + + + + + + + + + + + + + + +| 46 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant | X | 3 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + M + + + + + + + + M M + + + + M + + + +| 39 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 40 NTP Experiment-Test: 88034-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:41:57 __________________________________________________________________________________________________________________________________ | 7| 3| 6| 7| 6| 8| 7| 9| 8| 8| 9| 4| 7| 8| 8| 7| 8| 8| 8| 9| 9| 8| 7| 7| 6| | DAY ON TEST | 1| 8| 7| 9| 4| 4| 3| 1| 4| 4| 1| 4| 0| 2| 1| 3| 0| 8| 7| 1| 1| 3| 8| 2| 1| | | 6| 6| 8| 1| 9| 7| 5| 1| 5| 7| 2| 6| 7| 6| 2| 5| 5| 0| 5| 1| 2| 8| 7| 1| 6| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Lymphoma Malignant | X | 2 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hemangiosarcoma | X X | 3 | Lymphoma Malignant | X | 2 | __________________________________________________________________________|____________| Thymus | M + + + M M M M + M M + M + M + M M + + + + M M +| 26 | Lymphoma Malignant | X | 2 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Subcutaneous Tissue, Hemangiosarcoma | X | 2 | Subcutaneous Tissue, Sarcoma | X | 2 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Alveolar/Bronchiolar Adenoma | X X X X | 8 | Alveolar/Bronchiolar Carcinoma | X X X X X X | 10 | Alveolar/Bronchiolar Carcinoma, | | | Multiple | X X X X | 5 | Carcinoma, Metastatic, Harderian | | | Gland | X | 2 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X X | 4 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant | X | 1 | Mediastinum, Alveolar/Bronchiolar | | | Carcinoma, Metastatic, Lung | | 1 | Mediastinum, Hemangioma | X | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + A + + +| 48 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 41 NTP Experiment-Test: 88034-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:41:57 __________________________________________________________________________________________________________________________________ | 7| 3| 6| 7| 6| 8| 7| 9| 8| 8| 9| 4| 7| 8| 8| 7| 8| 8| 8| 9| 9| 8| 7| 7| 6| | DAY ON TEST | 1| 8| 7| 9| 4| 4| 3| 1| 4| 4| 1| 4| 0| 2| 1| 3| 0| 8| 7| 1| 1| 3| 8| 2| 1| | | 6| 6| 8| 1| 9| 7| 5| 1| 5| 7| 2| 6| 7| 6| 2| 5| 5| 0| 5| 1| 2| 8| 7| 1| 6| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Eye | +| 1 | __________________________________________________________________________|____________| Harderian Gland | + + + + +| 8 | Adenoma | X X X X| 5 | Carcinoma | X | 2 | __________________________________________________________________________|____________| Zymbal's Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Histiocytic Sarcoma | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Lymphoma Malignant | X | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant | X | 3 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 42 NTP Experiment-Test: 88034-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:41:57 _____________________________________________________________________________________________________________________ | 9| 9| 6| 7| 9| 8| 6| 4| 7| 6| 8| 9| 8| 6| 7| 9| 7| 9| 8| 5| 6| 8| 5| 5| 7| DAY ON TEST | 1| 1| 7| 4| 1| 1| 6| 6| 3| 2| 3| 1| 0| 2| 7| 1| 8| 1| 0| 8| 7| 7| 6| 7| 9| | 1| 2| 7| 9| 2| 9| 5| 9| 2| 8| 8| 2| 7| 0| 8| 2| 6| 1| 7| 1| 0| 4| 1| 2| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + A + + + + + A + + + + + + + A + + + + + + A +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + A + + + + M + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + M + + + + + + + + + + + + + + + + M + +| __________________________________________________________________________| Intestine Large, Cecum | + + A + + + + + A + A + + + + + A + + + + + + + +| Carcinoma | X | __________________________________________________________________________| Intestine Small, Duodenum | + + A + + + + + M A A + + + + + A + + + + + + A +| __________________________________________________________________________| Intestine Small, Jejunum | + + A + + + + + A + A + + + + + A + + + + + + + +| Lymphoma Malignant | X| Sarcoma, Metastatic, Uncertain | | Primary Site | | __________________________________________________________________________| Intestine Small, Ileum | + + A + + + + + A A A + + + + + A + + + + + + + +| Lymphoma Malignant | X| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | X X X X X X | Hepatocellular Carcinoma, Multiple | X X | Hepatocellular Adenoma | X X X X X X| Hepatocellular Adenoma, Multiple | X | Hepatocholangiocarcinoma | X | Sarcoma, Metastatic, Uncertain | | Primary Site | | __________________________________________________________________________| Mesentery | + + + + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Papilloma | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tooth | | Odontoma | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Hepatocellular Carcinoma, Metastatic,| | Liver | X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + M + + + + + + M + M + M M + M M + + + + M + I M| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + I + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 43 NTP Experiment-Test: 88034-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:41:57 _____________________________________________________________________________________________________________________ | 9| 9| 6| 7| 9| 8| 6| 4| 7| 6| 8| 9| 8| 6| 7| 9| 7| 9| 8| 5| 6| 8| 5| 5| 7| DAY ON TEST | 1| 1| 7| 4| 1| 1| 6| 6| 3| 2| 3| 1| 0| 2| 7| 1| 8| 1| 0| 8| 7| 7| 6| 7| 9| | 1| 2| 7| 9| 2| 9| 5| 9| 2| 8| 8| 2| 7| 0| 8| 2| 6| 1| 7| 1| 0| 4| 1| 2| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | __________________________________________________________________________| Penis | + + + + + + | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + M + + + + + + + + + + + +| Adenoma | | __________________________________________________________________________| Prostate | + + + + + + + M + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Interstitial Cell, Adenoma | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Femoral, Mast Cell Tumor NOS | X | __________________________________________________________________________| Lymph Node | + + +| Iliac, Lymphoma Malignant | | Renal, Lymphoma Malignant | X| __________________________________________________________________________| Lymph Node, Bronchial | M M M M + + M + + M + + + + M + M + M + M M + M M| Lymphoma Malignant | | Sarcoma, Metastatic, Uncertain | | Primary Site | | __________________________________________________________________________| Lymph Node, Mandibular | M + + M + + M + M + M + + M + + + + M + + + + + M| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + M + + + + M I + +| Lymphoma Malignant | X| Sarcoma, Metastatic, Uncertain | | Primary Site | | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + + + + M + + + M + + + + + + + M +| Carcinoma, Metastatic, Harderian | | Gland | X | Lymphoma Malignant | X| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Lymphoma Malignant | X| Mast Cell Tumor NOS | X | __________________________________________________________________________| Thymus | M M M + + M M + M + M + M + M M M + M M M + M I +| Lymphoma Malignant | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 44 NTP Experiment-Test: 88034-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:41:57 _____________________________________________________________________________________________________________________ | 9| 9| 6| 7| 9| 8| 6| 4| 7| 6| 8| 9| 8| 6| 7| 9| 7| 9| 8| 5| 6| 8| 5| 5| 7| DAY ON TEST | 1| 1| 7| 4| 1| 1| 6| 6| 3| 2| 3| 1| 0| 2| 7| 1| 8| 1| 0| 8| 7| 7| 6| 7| 9| | 1| 2| 7| 9| 2| 9| 5| 9| 2| 8| 8| 2| 7| 0| 8| 2| 6| 1| 7| 1| 0| 4| 1| 2| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M I| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteosarcoma | | __________________________________________________________________________| Skeletal Muscle | | Sarcoma, Metastatic, Uncertain | | Primary Site | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X | Alveolar/Bronchiolar Adenoma, | | Multiple | X | Alveolar/Bronchiolar Carcinoma | X X X X X | Alveolar/Bronchiolar Carcinoma, | | Multiple | X X | Carcinoma, Metastatic, Harderian | | Gland | X | Hepatocellular Carcinoma, Metastatic,| | Liver | X | Hepatocholangiocarcinoma, Metastatic,| | Liver | X | Lymphoma Malignant | X| Osteosarcoma, Metastatic, Bone | | Sarcoma, Metastatic, Uncertain | | Primary Site | | Mediastinum, | | Hepatocholangiocarcinoma, | | Metastatic, Liver | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | __________________________________________________________________________| Harderian Gland | + + | Adenoma | X | Carcinoma | X | _____________________________________________________________________________________________________________________| Page 45 NTP Experiment-Test: 88034-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:41:57 _____________________________________________________________________________________________________________________ | 9| 9| 6| 7| 9| 8| 6| 4| 7| 6| 8| 9| 8| 6| 7| 9| 7| 9| 8| 5| 6| 8| 5| 5| 7| DAY ON TEST | 1| 1| 7| 4| 1| 1| 6| 6| 3| 2| 3| 1| 0| 2| 7| 1| 8| 1| 0| 8| 7| 7| 6| 7| 9| | 1| 2| 7| 9| 2| 9| 5| 9| 2| 8| 8| 2| 7| 0| 8| 2| 6| 1| 7| 1| 0| 4| 1| 2| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + A + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant | X| _____________________________________________________________________________________________________________________| Page 46 NTP Experiment-Test: 88034-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:41:57 __________________________________________________________________________________________________________________________________ | 8| 2| 6| 6| 9| 9| 5| 8| 6| 8| 4| 9| 7| 6| 9| 8| 9| 7| 8| 6| 6| 8| 4| 9| 7| | DAY ON TEST | 3| 9| 1| 2| 1| 1| 5| 0| 8| 1| 3| 1| 4| 7| 1| 7| 1| 3| 2| 0| 7| 7| 0| 1| 1| | | 2| 7| 6| 3| 2| 2| 0| 8| 5| 2| 5| 1| 1| 7| 2| 7| 1| 0| 8| 9| 8| 5| 8| 2| 9| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | A + + + + + A + + + + + + A + + + + + + A + A + A| 40 | __________________________________________________________________________|____________| Intestine Large, Colon | A + + + + + A + + + + + + + + + + + + + A + A + A| 43 | __________________________________________________________________________|____________| Intestine Large, Rectum | A + + + + + + + + + + + + + + + + + + + A + A + A| 44 | __________________________________________________________________________|____________| Intestine Large, Cecum | A + + + + + A A + + + + + + + + + + + + A + A + A| 40 | Carcinoma | | 1 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + A A + + A + + + + + + + + + A + A + A| 38 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + A + + + A + + + + + + + + + A + A + A| 41 | Lymphoma Malignant | | 1 | Sarcoma, Metastatic, Uncertain | | | Primary Site | X | 1 | __________________________________________________________________________|____________| Intestine Small, Ileum | A + + + + + A + + + + + + + + + + + + + A + A + A| 40 | Lymphoma Malignant | | 1 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hepatocellular Carcinoma | X X X X X X X X| 14 | Hepatocellular Carcinoma, Multiple | X X X X X | 7 | Hepatocellular Adenoma | X X X X X | 11 | Hepatocellular Adenoma, Multiple | | 1 | Hepatocholangiocarcinoma | X | 2 | Sarcoma, Metastatic, Uncertain | | | Primary Site | X | 1 | __________________________________________________________________________|____________| Mesentery | | 4 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 | Lymphoma Malignant | X | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Squamous Cell Papilloma | X | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + A + + + + + + + + + + + + + A + + + +| 48 | __________________________________________________________________________|____________| Tooth | + | 1 | Odontoma | X | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + | 1 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + M + +| 49 | Adenoma | | 1 | Hepatocellular Carcinoma, Metastatic,| | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 47 NTP Experiment-Test: 88034-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:41:57 __________________________________________________________________________________________________________________________________ | 8| 2| 6| 6| 9| 9| 5| 8| 6| 8| 4| 9| 7| 6| 9| 8| 9| 7| 8| 6| 6| 8| 4| 9| 7| | DAY ON TEST | 3| 9| 1| 2| 1| 1| 5| 0| 8| 1| 3| 1| 4| 7| 1| 7| 1| 3| 2| 0| 7| 7| 0| 1| 1| | | 2| 7| 6| 3| 2| 2| 0| 8| 5| 2| 5| 1| 1| 7| 2| 7| 1| 0| 8| 9| 8| 5| 8| 2| 9| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Liver | | 1 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + M + +| 49 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + M M + M M M + + M M M M M M + + M + M M M| 25 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| 48 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | X | 1 | __________________________________________________________________________|____________| Penis | + | 7 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Adenoma | X | 1 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + M + + + + + + + + + + A| 47 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Interstitial Cell, Adenoma | X | 2 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | X | 2 | Femoral, Mast Cell Tumor NOS | | 1 | __________________________________________________________________________|____________| Lymph Node | + + + + | 7 | Iliac, Lymphoma Malignant | X | 1 | Renal, Lymphoma Malignant | X X | 3 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + + + + + M + + + + + M M + + + + + M + + M| 32 | Lymphoma Malignant | X | 1 | Sarcoma, Metastatic, Uncertain | | | Primary Site | X | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + M + + + + M M + + I M M + M M M + + + + M +| 32 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + M + + + + + + M + A + +| 44 | Lymphoma Malignant | X | 2 | Sarcoma, Metastatic, Uncertain | | | Primary Site | X | 1 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + M + + + + + + M + M + + + + + + + + + + + + + M| 43 | Carcinoma, Metastatic, Harderian | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 48 NTP Experiment-Test: 88034-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:41:57 __________________________________________________________________________________________________________________________________ | 8| 2| 6| 6| 9| 9| 5| 8| 6| 8| 4| 9| 7| 6| 9| 8| 9| 7| 8| 6| 6| 8| 4| 9| 7| | DAY ON TEST | 3| 9| 1| 2| 1| 1| 5| 0| 8| 1| 3| 1| 4| 7| 1| 7| 1| 3| 2| 0| 7| 7| 0| 1| 1| | | 2| 7| 6| 3| 2| 2| 0| 8| 5| 2| 5| 1| 1| 7| 2| 7| 1| 0| 8| 9| 8| 5| 8| 2| 9| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Gland | | 1 | Lymphoma Malignant | X | 2 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | X X X | 4 | Lymphoma Malignant | X | 2 | Mast Cell Tumor NOS | | 1 | __________________________________________________________________________|____________| Thymus | + + + M + + M + + I + + + + M M + M + M M + I + +| 25 | Lymphoma Malignant | X | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M + M M M M M + M M M M M M M M M M M M M M M M| 2 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Osteosarcoma | X | 1 | __________________________________________________________________________|____________| Skeletal Muscle | + | 1 | Sarcoma, Metastatic, Uncertain | | | Primary Site | X | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X X X X X X | 8 | Alveolar/Bronchiolar Adenoma, | | | Multiple | | 1 | Alveolar/Bronchiolar Carcinoma | X X X X X X X X X | 14 | Alveolar/Bronchiolar Carcinoma, | | | Multiple | X X | 4 | Carcinoma, Metastatic, Harderian | | | Gland | | 1 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X X X X X X | 7 | Hepatocholangiocarcinoma, Metastatic,| | | Liver | X | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 49 NTP Experiment-Test: 88034-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:41:57 __________________________________________________________________________________________________________________________________ | 8| 2| 6| 6| 9| 9| 5| 8| 6| 8| 4| 9| 7| 6| 9| 8| 9| 7| 8| 6| 6| 8| 4| 9| 7| | DAY ON TEST | 3| 9| 1| 2| 1| 1| 5| 0| 8| 1| 3| 1| 4| 7| 1| 7| 1| 3| 2| 0| 7| 7| 0| 1| 1| | | 2| 7| 6| 3| 2| 2| 0| 8| 5| 2| 5| 1| 1| 7| 2| 7| 1| 0| 8| 9| 8| 5| 8| 2| 9| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Lymphoma Malignant | | 1 | Osteosarcoma, Metastatic, Bone | X | 1 | Sarcoma, Metastatic, Uncertain | | | Primary Site | X | 1 | Mediastinum, | | | Hepatocholangiocarcinoma, | | | Metastatic, Liver | X | 1 | __________________________________________________________________________|____________| Nose | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 1 | __________________________________________________________________________|____________| Harderian Gland | + + + | 5 | Adenoma | X X X | 4 | Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant | X X | 3 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 50 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------