TDMS Study 88034-06 Pathology Tables
NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
Facility: Battelle Northwest
Chemical CAS #: 10028-15-6
Lock Date: 03/09/93
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
_____________________________________________________________________________________________________________________
| 7| 8| 8| 8| 6| 9| 4| 5| 8| 9| 7| 7| 9| 9| 5| 8| 7| 7| 8| 8| 5| 7| 8| 8| 8|
DAY ON TEST | 7| 0| 6| 4| 2| 1| 0| 5| 4| 1| 9| 9| 1| 1| 3| 4| 4| 4| 6| 4| 2| 2| 0| 7| 2|
| 8| 5| 0| 0| 1| 1| 3| 6| 0| 2| 1| 0| 2| 2| 7| 7| 9| 9| 9| 1| 1| 4| 1| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + I + + + + + + + A + + + + +|
Inflammation, Suppurative | |
Epithelium, Hyperplasia | 2 4 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + A + + + + + + + M + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + A + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + A + + + + + + + A + + + + +|
Necrosis | |
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + A + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + A + + + + + + + A + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | X |
Clear Cell Focus | X |
Eosinophilic Focus | X X |
Hematopoietic Cell Proliferation | 2 2 2 |
Inflammation, Chronic | |
Necrosis | 2 1 2 |
Pigmentation | 2 |
Vacuolization Cytoplasmic, Focal | 2 |
Bile Duct, Cyst | 3 |
Bile Duct, Hyperplasia | 1 |
Centrilobular, Degeneration | 2 |
Centrilobular, Necrosis | 1 |
Hepatocyte, Atrophy | |
__________________________________________________________________________|
Mesentery | + + + + |
Artery, Inflammation | |
Fat, Inflammation, Chronic | |
Fat, Necrosis | 3 4 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 1 4 4 |
Inflammation | 2 |
Duct, Cyst | 3 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 2 |
Necrosis | |
Epithelium, Hyperplasia | 2 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
_____________________________________________________________________________________________________________________
| 7| 8| 8| 8| 6| 9| 4| 5| 8| 9| 7| 7| 9| 9| 5| 8| 7| 7| 8| 8| 5| 7| 8| 8| 8|
DAY ON TEST | 7| 0| 6| 4| 2| 1| 0| 5| 4| 1| 9| 9| 1| 1| 3| 4| 4| 4| 6| 4| 2| 2| 0| 7| 2|
| 8| 5| 0| 0| 1| 1| 3| 6| 0| 2| 1| 0| 2| 2| 7| 7| 9| 9| 9| 1| 1| 4| 1| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1|
Necrosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hyperplasia | 2 2 |
Hypertrophy | 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + M + + + + + + M + + + + + + + + M|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + I + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 1 4 1 |
Pars Intermedia, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 1 4 4 2 2 4 1 1 4 1 1 4 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + M + + + + + M + + + + + + +|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Atrophy | 2 2 3 4 2 3 2 4 3 3 4 2 3 4 4 3 |
Cyst | 2 4 2 1 3 1 2 2 2 2 3 |
Inflammation, Chronic | |
Germinal Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | 4 3|
Hydrometra | 4 |
Thrombosis | 4 3 |
Endometrium, Hyperplasia | |
Myometrium, Hyperplasia | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
_____________________________________________________________________________________________________________________
| 7| 8| 8| 8| 6| 9| 4| 5| 8| 9| 7| 7| 9| 9| 5| 8| 7| 7| 8| 8| 5| 7| 8| 8| 8|
DAY ON TEST | 7| 0| 6| 4| 2| 1| 0| 5| 4| 1| 9| 9| 1| 1| 3| 4| 4| 4| 6| 4| 2| 2| 0| 7| 2|
| 8| 5| 0| 0| 1| 1| 3| 6| 0| 2| 1| 0| 2| 2| 7| 7| 9| 9| 9| 1| 1| 4| 1| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Angiectasis | 2 |
Hyperplasia | 3 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + +|
Hyperplasia | 2 |
Iliac, Angiectasis | 4 3 |
Iliac, Hyperplasia | |
Lumbar, Congestion | 3 |
Renal, Congestion | 3 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + M + + + M + + + + + + + M M + + + + M M M|
Hyperplasia | 2 |
Infiltration Cellular, Plasma Cell | 2 |
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + M + + + M + + M + + + M + + + M +|
Hyperplasia | |
Necrosis | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + M + + + + M + + + + + + + + M + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + M + M + + + + + + + + + + + + + + M + + +|
Hyperplasia | 2 2 3 |
Infiltration Cellular, Histiocyte | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 3 3 2 2 2 2 2 2 3|
Hyperplasia, Lymphoid | 2 4 2 2 |
__________________________________________________________________________|
Thymus | M + M + M + + + M + M + + + + + M + + + + + + + M|
Atrophy | 3 2 |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 1 2 2 3 1 1 |
Fracture | |
Cranium, Fracture | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Meninges, Infiltration Cellular | 2 2 |
__________________________________________________________________________|
Peripheral Nerve | + |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
_____________________________________________________________________________________________________________________
| 7| 8| 8| 8| 6| 9| 4| 5| 8| 9| 7| 7| 9| 9| 5| 8| 7| 7| 8| 8| 5| 7| 8| 8| 8|
DAY ON TEST | 7| 0| 6| 4| 2| 1| 0| 5| 4| 1| 9| 9| 1| 1| 3| 4| 4| 4| 6| 4| 2| 2| 0| 7| 2|
| 8| 5| 0| 0| 1| 1| 3| 6| 0| 2| 1| 0| 2| 2| 7| 7| 9| 9| 9| 1| 1| 4| 1| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Degeneration | 2 |
__________________________________________________________________________|
Spinal Cord | + |
Degeneration | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 1 1 3 1|
Inflammation, Chronic Active | 1 1 1 1 |
Inflammation, Suppurative | 1 1 1 |
Epiglottis, Metaplasia, Squamous | 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Inflammation, Chronic, Focal | 1 |
Alveolar Epithelium, Hyperplasia | 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 3 2 2 2 |
Perivascular, Infiltration Cellular | 2 3 2 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lateral Wall, Fibrosis | 1 |
Lateral Wall, Hyperplasia | 1 |
Lateral Wall, Inflammation, | |
Suppurative | 1 1 1 |
Lateral Wall, Metaplasia, Squamous | 1 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 1 |
Olfactory Epithelium, Atrophy | 1 2 1 1 2 1 |
Turbinate, Hyperplasia | |
Turbinate, Inflammation, Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | 2 |
Hydronephrosis | 2|
Metaplasia, Osseous | 1 1 1 |
Nephropathy | 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + A + + + + +|
Inflammation, Suppurative | 4 |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
__________________________________________________________________________________________________________________________________
| 9| 7| 9| 7| 7| 8| 6| 7| 8| 9| 5| 8| 8| 9| 7| 7| 7| 7| 7| 9| 8| 8| 8| 4| 5| |
DAY ON TEST | 1| 2| 1| 2| 7| 8| 7| 9| 8| 1| 2| 4| 6| 1| 5| 9| 9| 1| 2| 1| 5| 2| 2| 0| 4| |
| 1| 1| 2| 1| 5| 4| 8| 1| 3| 1| 7| 9| 5| 2| 4| 1| 6| 7| 2| 2| 7| 6| 4| 8| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + A + + + + + + +| 49 |
__________________________________________________________________________|____________|
Gallbladder | + + + + A + + + + + + A A + + + + A + + + + + A +| 43 |
Inflammation, Suppurative | 2 | 1 2.0|
Epithelium, Hyperplasia | | 2 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + A + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + A + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + A + + + + + + + + + + + + A + + + + + A +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + A + + + + + + + A + + + + + + + + + + A +| 45 |
Necrosis | 1 | 1 1.0|
Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A + + + + + + + A + + + + A + + + + + A +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + A + + + + A + + + + + A +| 45 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + A + + + + + + +| 49 |
Angiectasis | | 1 2.0|
Basophilic Focus | | 1 |
Clear Cell Focus | | 1 |
Eosinophilic Focus | X | 3 |
Hematopoietic Cell Proliferation | 1 | 4 1.8|
Inflammation, Chronic | 2 2 | 2 2.0|
Necrosis | 1 2 1 2 | 7 1.6|
Pigmentation | 2 | 2 2.0|
Vacuolization Cytoplasmic, Focal | | 1 2.0|
Bile Duct, Cyst | | 1 3.0|
Bile Duct, Hyperplasia | | 1 1.0|
Centrilobular, Degeneration | | 1 2.0|
Centrilobular, Necrosis | | 1 1.0|
Hepatocyte, Atrophy | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + | 13 |
Artery, Inflammation | 2 | 1 2.0|
Fat, Inflammation, Chronic | 2 | 1 2.0|
Fat, Necrosis | 2 3 2 2 2 2 | 9 2.6|
__________________________________________________________________________|____________|
Pancreas | + + + + A + + + + + + + + + + + + A + + + + + + +| 48 |
Atrophy | 2 | 5 3.0|
Inflammation | 2 | 2 2.0|
Duct, Cyst | | 2 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + A + + + + + A +| 48 |
Inflammation, Suppurative | | 2 1.5|
Necrosis | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
__________________________________________________________________________________________________________________________________
| 9| 7| 9| 7| 7| 8| 6| 7| 8| 9| 5| 8| 8| 9| 7| 7| 7| 7| 7| 9| 8| 8| 8| 4| 5| |
DAY ON TEST | 1| 2| 1| 2| 7| 8| 7| 9| 8| 1| 2| 4| 6| 1| 5| 9| 9| 1| 2| 1| 5| 2| 2| 0| 4| |
| 1| 1| 2| 1| 5| 4| 8| 1| 3| 1| 7| 9| 5| 2| 4| 1| 6| 7| 2| 2| 7| 6| 4| 8| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Epithelium, Hyperplasia | 2 | 3 2.7|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + A + + + + + A +| 48 |
Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Tooth | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 37 1.1|
Necrosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + M A + + + + + + +| 48 |
Angiectasis | | 1 2.0|
Hyperplasia | 1| 3 1.7|
Hypertrophy | 1 1 2 1 1 | 6 1.2|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + M A + + + + + + +| 48 |
Hyperplasia | 1 1 2 | 4 1.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + A M + + + + + + + + + + + A + + + + + + +| 47 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | M + + M M + + M + + + + M + + + M M + M + + + M M| 36 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + A + + + + + + +| 48 |
Pars Distalis, Hyperplasia | 1 2 1 4 1 2 3 1 | 11 1.9|
Pars Intermedia, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + A + + + + + + +| 49 |
Follicular Cell, Hyperplasia | 2 2 2 1 1 1 1 1 3 2 | 22 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + M M + + + + + + + + + + M +| 45 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + A + + + + + + +| 49 |
Angiectasis | 2 2 | 3 2.0|
Atrophy | 3 2 2 3 4 2 3 3 4 3 3 3 | 28 3.0|
Cyst | 2 3 1 3 3 1 3 4 3 3 2 2| 23 2.3|
Inflammation, Chronic | 4 | 1 4.0|
Germinal Epithelium, Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
__________________________________________________________________________________________________________________________________
| 9| 7| 9| 7| 7| 8| 6| 7| 8| 9| 5| 8| 8| 9| 7| 7| 7| 7| 7| 9| 8| 8| 8| 4| 5| |
DAY ON TEST | 1| 2| 1| 2| 7| 8| 7| 9| 8| 1| 2| 4| 6| 1| 5| 9| 9| 1| 2| 1| 5| 2| 2| 0| 4| |
| 1| 1| 2| 1| 5| 4| 8| 1| 3| 1| 7| 9| 5| 2| 4| 1| 6| 7| 2| 2| 7| 6| 4| 8| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + A + + + + + + +| 49 |
Angiectasis | 1 2 4 4 | 4 2.8|
Cyst | 2 2 3 4 | 6 3.0|
Hydrometra | 3 3 | 3 3.3|
Thrombosis | | 2 3.5|
Endometrium, Hyperplasia | 3 | 1 3.0|
Myometrium, Hyperplasia | | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + A + + + + + + +| 49 |
Angiectasis | 2 | 2 2.0|
Hyperplasia | | 3 2.3|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + | 15 |
Hyperplasia | | 1 2.0|
Iliac, Angiectasis | | 2 3.5|
Iliac, Hyperplasia | 2 | 1 2.0|
Lumbar, Congestion | | 1 3.0|
Renal, Congestion | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + + + + + + + + + M M + M + + + M M M + + + +| 36 |
Hyperplasia | | 1 2.0|
Infiltration Cellular, Plasma Cell | | 1 2.0|
Infiltration Cellular, Histiocyte | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + M + + + + + + + M + + M M A + + + + + M +| 38 |
Hyperplasia | 2 2 | 2 2.0|
Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + A + + + + + A +| 45 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + M + + + M + + + + + + M + + + + + + + + + M +| 43 |
Hyperplasia | 2 3 | 5 2.4|
Infiltration Cellular, Histiocyte | 2 | 2 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + A + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 2 2 2 2 | 15 2.2|
Hyperplasia, Lymphoid | 2 2 | 6 2.3|
__________________________________________________________________________|____________|
Thymus | + + + M + + M M + M + + + + + M + + M M + M + + +| 35 |
Atrophy | | 2 2.5|
Hyperplasia, Lymphoid | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
__________________________________________________________________________________________________________________________________
| 9| 7| 9| 7| 7| 8| 6| 7| 8| 9| 5| 8| 8| 9| 7| 7| 7| 7| 7| 9| 8| 8| 8| 4| 5| |
DAY ON TEST | 1| 2| 1| 2| 7| 8| 7| 9| 8| 1| 2| 4| 6| 1| 5| 9| 9| 1| 2| 1| 5| 2| 2| 0| 4| |
| 1| 1| 2| 1| 5| 4| 8| 1| 3| 1| 7| 9| 5| 2| 4| 1| 6| 7| 2| 2| 7| 6| 4| 8| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 1 2 1 3 2 2 2 1 1 | 15 1.7|
Fracture | X | 1 |
Cranium, Fracture | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + A + + + + + + +| 49 |
Angiectasis | 2 | 1 2.0|
Meninges, Infiltration Cellular | | 2 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
Degeneration | | 1 2.0|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
Degeneration | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 1 1 1 2 1 | 13 1.2|
Inflammation, Chronic Active | | 4 1.0|
Inflammation, Suppurative | 1 1 | 5 1.0|
Epiglottis, Metaplasia, Squamous | 1| 2 1.5|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 2.0|
Inflammation, Chronic, Focal | | 1 1.0|
Alveolar Epithelium, Hyperplasia | 2 2 | 3 1.7|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 5 2.2|
Perivascular, Infiltration Cellular | 1 | 6 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lateral Wall, Fibrosis | | 1 1.0|
Lateral Wall, Hyperplasia | | 1 1.0|
Lateral Wall, Inflammation, | | |
Suppurative | | 3 1.0|
Lateral Wall, Metaplasia, Squamous | 1 | 2 1.0|
Nasolacrimal Duct, Inflammation, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
__________________________________________________________________________________________________________________________________
| 9| 7| 9| 7| 7| 8| 6| 7| 8| 9| 5| 8| 8| 9| 7| 7| 7| 7| 7| 9| 8| 8| 8| 4| 5| |
DAY ON TEST | 1| 2| 1| 2| 7| 8| 7| 9| 8| 1| 2| 4| 6| 1| 5| 9| 9| 1| 2| 1| 5| 2| 2| 0| 4| |
| 1| 1| 2| 1| 5| 4| 8| 1| 3| 1| 7| 9| 5| 2| 4| 1| 6| 7| 2| 2| 7| 6| 4| 8| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Suppurative | 2 | 2 1.5|
Olfactory Epithelium, Atrophy | 2 2 1 | 9 1.4|
Turbinate, Hyperplasia | 2 | 1 2.0|
Turbinate, Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + A + + + + + + + + + + + + A + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + + | 5 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + A + + + + + + +| 49 |
Fibrosis, Focal | | 1 2.0|
Hydronephrosis | | 1 2.0|
Metaplasia, Osseous | 1 | 4 1.0|
Nephropathy | 1 1 1 1 1 1 2 1 1 1 1 1 1 2| 24 1.1|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + A + + + + + + + + + + + + A + + + + + + +| 47 |
Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
_____________________________________________________________________________________________________________________
| 5| 8| 8| 8| 7| 8| 8| 8| 9| 9| 8| 9| 9| 7| 8| 9| 5| 9| 7| 7| 6| 8| 8| 6| 7|
DAY ON TEST | 7| 0| 6| 2| 8| 7| 5| 2| 1| 1| 0| 1| 1| 9| 6| 1| 4| 1| 8| 7| 7| 8| 7| 9| 5|
| 1| 5| 3| 1| 5| 7| 5| 6| 2| 2| 7| 2| 2| 2| 1| 2| 4| 1| 4| 5| 8| 0| 5| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + A + M A + + + + + + + + + + M + + + + A A|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + A + + + + + + + + + + A + + + + A +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + + A + + + + A A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + A + + + + A A|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + A + + + + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | |
Eosinophilic Focus | X X |
Inflammation, Chronic | 2 2 |
Necrosis | 4 3 |
Pigmentation | |
Bile Duct, Cyst | |
Centrilobular, Necrosis | 1 |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + A + + + + + +|
Atrophy | |
Duct, Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 2|
Necrosis | |
Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Necrosis | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 2 1 1 1 2 1 2 1 1 2 1 1 1 2 1 1 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 |
Hypertrophy | 1 1 |
Capsule, Hyperplasia | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + A M + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + M M M M M + M + M M + + + + + + M I + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
_____________________________________________________________________________________________________________________
| 5| 8| 8| 8| 7| 8| 8| 8| 9| 9| 8| 9| 9| 7| 8| 9| 5| 9| 7| 7| 6| 8| 8| 6| 7|
DAY ON TEST | 7| 0| 6| 2| 8| 7| 5| 2| 1| 1| 0| 1| 1| 9| 6| 1| 4| 1| 8| 7| 7| 8| 7| 9| 5|
| 1| 5| 3| 1| 5| 7| 5| 6| 2| 2| 7| 2| 2| 2| 1| 2| 4| 1| 4| 5| 8| 0| 5| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Hyperplasia | 1 4 3 1 2 4 4 2 |
Pars Intermedia, Hyperplasia | 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 1 4 2 3 2 3 3 2 2 1 3 1 2 3 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + M + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Atrophy | 2 2 2 4 3 2 3 2 2 3 2 2 3 3 2 3 2 2 |
Cyst | 4 2 1 4 3 1 2 2 1 1 1 |
Necrosis | |
Germinal Epithelium, Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 |
Cyst | 3 |
Hemorrhage | 4 |
Hydrometra | 2 3 4 2 |
Inflammation, Suppurative | |
Endometrium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + |
__________________________________________________________________________|
Lymph Node, Bronchial | + M + M + + + M M + + + M + M M + + + + + M M M M|
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + I + + + + + + + + + + + M + M + + + + + + M|
Hematopoietic Cell Proliferation | |
Hyperplasia | 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hematopoietic Cell Proliferation | |
Hyperplasia | |
Infiltration Cellular, Histiocyte | 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + M M M M + + + + + + + M + M|
Hyperplasia | 2 2 2 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 2 2 4 2 2 3 2 |
Hyperplasia, Histiocytic | 2 |
Hyperplasia, Lymphoid | 2 2 2 4 2 2 3 |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
_____________________________________________________________________________________________________________________
| 5| 8| 8| 8| 7| 8| 8| 8| 9| 9| 8| 9| 9| 7| 8| 9| 5| 9| 7| 7| 6| 8| 8| 6| 7|
DAY ON TEST | 7| 0| 6| 2| 8| 7| 5| 2| 1| 1| 0| 1| 1| 9| 6| 1| 4| 1| 8| 7| 7| 8| 7| 9| 5|
| 1| 5| 3| 1| 5| 7| 5| 6| 2| 2| 7| 2| 2| 2| 1| 2| 4| 1| 4| 5| 8| 0| 5| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Infiltration Cellular, Histiocyte | 3 |
__________________________________________________________________________|
Thymus | M + + + + M M + + + + + M + + M + + + + M + M + +|
Atrophy | 3|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 1 2 2 3 3 2 1 3 2 1 1 1|
Cranium, Myelofibrosis | X |
Femur, Myelofibrosis | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Meninges, Infiltration Cellular | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 1 2 2 |
Inflammation, Suppurative | 1 |
Epiglottis, Metaplasia, Squamous | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 2 |
Alveolar Epithelium, Hyperplasia | 2 |
Alveolar Epithelium, Metaplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1|
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 2 1 1|
Mediastinum, Angiectasis | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation | |
Lateral Wall, Degeneration, Hyaline | 3 2 2 2 2 2 1 2 2 3 2 2 2 2 2 2 3 2 1 2 2 2 2 2 2|
Lateral Wall, Fibrosis | 2 1 2 1 1 1 1 1 1 1 1 1 1 |
Lateral Wall, Hyperplasia | 2 2 2 2 2 1 2 2 3 2 2 2 2 2 2 2 1 2 2 1 2 2 1|
Lateral Wall, Inflammation, | |
Suppurative | 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Lateral Wall, Metaplasia, Squamous | 1 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 1 |
Olfactory Epithelium, Atrophy | 2 3 1 3 1 2 2 2 2 2 2 3 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + A + + + + + +|
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
_____________________________________________________________________________________________________________________
| 5| 8| 8| 8| 7| 8| 8| 8| 9| 9| 8| 9| 9| 7| 8| 9| 5| 9| 7| 7| 6| 8| 8| 6| 7|
DAY ON TEST | 7| 0| 6| 2| 8| 7| 5| 2| 1| 1| 0| 1| 1| 9| 6| 1| 4| 1| 8| 7| 7| 8| 7| 9| 5|
| 1| 5| 3| 1| 5| 7| 5| 6| 2| 2| 7| 2| 2| 2| 1| 2| 4| 1| 4| 5| 8| 0| 5| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Inflammation, Granulomatous | |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 4 |
Metaplasia, Osseous | |
Nephropathy | 2 1 1 1 1 1 1 1 1 1 1 1 1 |
Pelvis, Dilatation | 3 |
Renal Tubule, Hyperplasia | 4 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + A + + + + + +|
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
__________________________________________________________________________________________________________________________________
| 7| 9| 9| 9| 8| 6| 5| 6| 7| 8| 9| 9| 7| 8| 8| 9| 8| 7| 6| 8| 7| 7| 7| 6| 8| |
DAY ON TEST | 2| 1| 1| 1| 7| 2| 9| 1| 6| 5| 1| 1| 8| 8| 8| 1| 7| 5| 2| 1| 6| 9| 2| 1| 5| |
| 6| 2| 2| 1| 5| 1| 5| 6| 3| 5| 2| 1| 6| 0| 3| 2| 4| 0| 3| 7| 6| 2| 1| 6| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + A A + + + + + + A + + + + + + + A A + A +| 38 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + M + + A + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + A + + + + + + + A + + A +| 43 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + A + + A + + + + M + + + + + M + A + + + +| 41 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A A + A + + + + + + + + + + + + A + + + +| 42 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + A A + + + + + + A + + + + + + + A + + + +| 43 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Fatty | 2 | 1 2.0|
Eosinophilic Focus | X X X X | 6 |
Inflammation, Chronic | 2 1 | 4 1.8|
Necrosis | 2 | 3 3.0|
Pigmentation | 2 2 | 2 2.0|
Bile Duct, Cyst | 3 2 | 2 2.5|
Centrilobular, Necrosis | | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | + + | 5 |
Fat, Necrosis | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
Atrophy | 4 | 1 4.0|
Duct, Cyst | 4 | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 2 | 3 1.7|
Necrosis | 2 | 1 2.0|
Epithelium, Hyperplasia | 1 | 2 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
Inflammation, Acute | 1 | 1 1.0|
Necrosis | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 2| 38 1.2|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
Hyperplasia | | 2 1.5|
Hypertrophy | 1 1 1 | 5 1.0|
Capsule, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
__________________________________________________________________________________________________________________________________
| 7| 9| 9| 9| 8| 6| 5| 6| 7| 8| 9| 9| 7| 8| 8| 9| 8| 7| 6| 8| 7| 7| 7| 6| 8| |
DAY ON TEST | 2| 1| 1| 1| 7| 2| 9| 1| 6| 5| 1| 1| 8| 8| 8| 1| 7| 5| 2| 1| 6| 9| 2| 1| 5| |
| 6| 2| 2| 1| 5| 1| 5| 6| 3| 5| 2| 1| 6| 0| 3| 2| 4| 0| 3| 7| 6| 2| 1| 6| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
Hyperplasia | 3 1 | 3 1.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + A + + + +| 47 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M M + M + M + + + + + M + M M + + + + M + + M M| 28 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + M + + + + + + A + + + +| 48 |
Pars Distalis, Hyperplasia | 4 3 2 2 1 2 | 14 2.5|
Pars Intermedia, Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
Follicular Cell, Hyperplasia | 1 1 1 2 2 2 1 3 1| 24 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + M + + + + M + + + + + + + + + + + + M M + + +| 44 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + A + I + +| 48 |
Angiectasis | 2 | 2 2.0|
Atrophy | 2 2 3 2 3 2 2 1 2 3 2 2 4 3 1 | 33 2.4|
Cyst | 1 2 2 3 1 2 2 | 18 1.9|
Necrosis | 4| 1 4.0|
Germinal Epithelium, Hyperplasia | 1 | 4 1.8|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 3 2.0|
Cyst | 2 | 2 2.5|
Hemorrhage | | 1 4.0|
Hydrometra | 4 | 5 3.0|
Inflammation, Suppurative | 2 | 1 2.0|
Endometrium, Hyperplasia | 2 1 | 2 1.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + | 6 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + I + M M M + + + + + + + + + + + + A + M + +| 32 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + I + + M + + M + + + + M + + + + + + A + + + +| 40 |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hyperplasia | 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + A M + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
__________________________________________________________________________________________________________________________________
| 7| 9| 9| 9| 8| 6| 5| 6| 7| 8| 9| 9| 7| 8| 8| 9| 8| 7| 6| 8| 7| 7| 7| 6| 8| |
DAY ON TEST | 2| 1| 1| 1| 7| 2| 9| 1| 6| 5| 1| 1| 8| 8| 8| 1| 7| 5| 2| 1| 6| 9| 2| 1| 5| |
| 6| 2| 2| 1| 5| 1| 5| 6| 3| 5| 2| 1| 6| 0| 3| 2| 4| 0| 3| 7| 6| 2| 1| 6| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Congestion | 2 | 2 2.0|
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hyperplasia | 4 | 1 4.0|
Infiltration Cellular, Histiocyte | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M M + + + M M + + M M + M + + + + + + A + + + +| 36 |
Hyperplasia | 2 2 2 3 | 9 2.1|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 2 3 3 | 19 2.3|
Hyperplasia, Histiocytic | | 1 2.0|
Hyperplasia, Lymphoid | 2 2 | 9 2.3|
Infiltration Cellular, Histiocyte | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + I + + + + + M M + + + + + M M + M + A + + + M| 35 |
Atrophy | 3 4 | 3 3.3|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 1 2 3 2 1 1 | 18 1.8|
Cranium, Myelofibrosis | | 1 |
Femur, Myelofibrosis | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
Meninges, Infiltration Cellular | 1 3 | 2 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
Hyperplasia | 1 1 1 1 2| 11 1.3|
Inflammation, Suppurative | 1 1 1| 4 1.0|
Epiglottis, Metaplasia, Squamous | 1 1| 2 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
Hemorrhage | | 2 1.5|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
Alveolar Epithelium, Metaplasia | 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 43 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
__________________________________________________________________________________________________________________________________
| 7| 9| 9| 9| 8| 6| 5| 6| 7| 8| 9| 9| 7| 8| 8| 9| 8| 7| 6| 8| 7| 7| 7| 6| 8| |
DAY ON TEST | 2| 1| 1| 1| 7| 2| 9| 1| 6| 5| 1| 1| 8| 8| 8| 1| 7| 5| 2| 1| 6| 9| 2| 1| 5| |
| 6| 2| 2| 1| 5| 1| 5| 6| 3| 5| 2| 1| 6| 0| 3| 2| 4| 0| 3| 7| 6| 2| 1| 6| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 1 1 2 3 2 2 1 1 1 1 1 1 1 1 1 4| 39 1.3|
Mediastinum, Angiectasis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
Artery, Inflammation | 2 | 1 2.0|
Lateral Wall, Degeneration, Hyaline | 1 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3| 49 2.0|
Lateral Wall, Fibrosis | 1 1 1 1 1 1 1 1 1 1| 23 1.1|
Lateral Wall, Hyperplasia | 1 2 2 2 2 1 2 2 2 2 1 2 2 2 2 2 1 2 3| 42 1.9|
Lateral Wall, Inflammation, | | |
Suppurative | 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1| 44 1.0|
Lateral Wall, Metaplasia, Squamous | 1 1| 3 1.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 1 1.0|
Olfactory Epithelium, Atrophy | 2 2 1 2 2 2 2 2 1 1| 23 1.9|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
Inflammation, Granulomatous | 3 | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + | 5 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
Infarct | | 1 4.0|
Metaplasia, Osseous | 1 | 1 1.0|
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 27 1.0|
Pelvis, Dilatation | | 1 3.0|
Renal Tubule, Hyperplasia | | 2 2.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
_____________________________________________________________________________________________________________________
| 7| 7| 6| 8| 8| 8| 5| 9| 6| 9| 6| 7| 9| 5| 9| 5| 6| 7| 8| 6| 6| 7| 7| 7| 8|
DAY ON TEST | 4| 8| 9| 5| 7| 6| 8| 0| 6| 1| 9| 3| 1| 5| 1| 8| 5| 7| 4| 7| 6| 2| 6| 4| 3|
| 1| 6| 6| 5| 4| 9| 8| 3| 0| 1| 7| 5| 1| 9| 2| 6| 1| 4| 7| 8| 5| 2| 7| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | A + + + + + + + I + + + + + + + + A + + + + A + +|
__________________________________________________________________________|
Intestine Large, Colon | A + + + + + + M + + + + + + + + + A + + + + A + +|
__________________________________________________________________________|
Intestine Large, Rectum | A + + + + + + + + + + + + + + + + A + + + + A + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + + + A + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + A + + + + + + + + M + + + + A + +|
Necrosis | |
Peyer's Patch, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + + + + + + + + + + A + + + + A + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + + A + + + + + + + + A + + + + A + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X |
Eosinophilic Focus | X |
Hematopoietic Cell Proliferation | 1 2 1 |
Inflammation, Chronic | |
Necrosis | 1 2 |
Pigmentation | 1 |
Bile Duct, Hyperplasia | |
__________________________________________________________________________|
Mesentery | + + + + + + +|
Fat, Necrosis | 2 4 3 |
Lymphatic, Angiectasis | |
__________________________________________________________________________|
Oral Mucosa | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Basophilic Focus | X X X |
Inflammation | 2 |
Duct, Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + M + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
Necrosis | 3 |
Epithelium, Hyperplasia | 4 1 |
__________________________________________________________________________|
Stomach, Glandular | + + M + + + + + + + + + + + + + + A + + + + + + +|
Mineralization | |
Epithelium, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 2 1 2 1 1 1 1 1 1 1 1 1 1 1|
Inflammation, Suppurative | |
Pigmentation, Hemosiderin | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
_____________________________________________________________________________________________________________________
| 7| 7| 6| 8| 8| 8| 5| 9| 6| 9| 6| 7| 9| 5| 9| 5| 6| 7| 8| 6| 6| 7| 7| 7| 8|
DAY ON TEST | 4| 8| 9| 5| 7| 6| 8| 0| 6| 1| 9| 3| 1| 5| 1| 8| 5| 7| 4| 7| 6| 2| 6| 4| 3|
| 1| 6| 6| 5| 4| 9| 8| 3| 0| 1| 7| 5| 1| 9| 2| 6| 1| 4| 7| 8| 5| 2| 7| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
Hypertrophy | 1 1 1 |
Capsule, Hyperplasia | 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + M + + + + M + M + M + + M M + + + + M + M M|
__________________________________________________________________________|
Pituitary Gland | + + + + + I + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 1 4 1 1 1 2 |
Pars Intermedia, Hyperplasia | |
Pars Intermedia, Hypertrophy | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 1 2 1 1 1 3 3 1 4 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M M + + + + + + + + + + + + + + + + I + M + + M M|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Atrophy | 2 3 2 3 3 2 2 3 2 3 2 3 2|
Cyst | 2 2 4 1 1 2 2 2 2|
Inflammation, Chronic | 2 |
Interstitial Cell, Hyperplasia | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Cyst | 3 2 |
Decidual Reaction | |
Hydrometra | 3 |
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 4 3 |
__________________________________________________________________________|
Lymph Node | + + + + |
Lumbar, Hyperplasia | |
Renal, Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | M M + + M M + M + + + M M + + M M + + + M M M M +|
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + M + + + + M M + M + + + M + M + + +|
Hyperplasia | 2 3 |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
_____________________________________________________________________________________________________________________
| 7| 7| 6| 8| 8| 8| 5| 9| 6| 9| 6| 7| 9| 5| 9| 5| 6| 7| 8| 6| 6| 7| 7| 7| 8|
DAY ON TEST | 4| 8| 9| 5| 7| 6| 8| 0| 6| 1| 9| 3| 1| 5| 1| 8| 5| 7| 4| 7| 6| 2| 6| 4| 3|
| 1| 6| 6| 5| 4| 9| 8| 3| 0| 1| 7| 5| 1| 9| 2| 6| 1| 4| 7| 8| 5| 2| 7| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mesenteric | + M + + + + + M + + + + + + M + + + + + + + A + +|
Angiectasis | 3 |
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + M + M + + M + + + + + + M M + + M +|
Hyperplasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 4 2 2 2 4 2 2 3 2 2 2 2 2 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Thymus | M M + M M + + M + + + + M + M M + + M + M + + + +|
Atrophy | 2 |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Vulva, Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Chondradysplasia | X |
Fibrous Osteodystrophy | 2 1 1 2 2 1 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | |
Meninges, Infiltration Cellular | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 3 1 2 1 2 1 1 1|
Inflammation, Suppurative | 1 1 1 |
Necrosis | |
Epiglottis, Hyperplasia | |
Epiglottis, Metaplasia, Squamous | 1 1 1 1 1 1 2 1 1 1 1 1 1|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion, Chronic | |
Hemorrhage | |
Alveolar Epithelium, Hyperplasia | 1 |
Alveolar Epithelium, Metaplasia | 3 2 1 3 2 2 3 1 1 3 2 2 1 3 2 2 2 2 3 3 3 2 1 2 2|
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 1 1 2 2 2 2 1 2 2 1 1 1 3 2 2 3 2 2 1 1 2 2|
Mediastinum, Necrosis | 2 |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
_____________________________________________________________________________________________________________________
| 7| 7| 6| 8| 8| 8| 5| 9| 6| 9| 6| 7| 9| 5| 9| 5| 6| 7| 8| 6| 6| 7| 7| 7| 8|
DAY ON TEST | 4| 8| 9| 5| 7| 6| 8| 0| 6| 1| 9| 3| 1| 5| 1| 8| 5| 7| 4| 7| 6| 2| 6| 4| 3|
| 1| 6| 6| 5| 4| 9| 8| 3| 0| 1| 7| 5| 1| 9| 2| 6| 1| 4| 7| 8| 5| 2| 7| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Perivascular, Infiltration Cellular | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lateral Wall, Degeneration, Hyaline | 3 2 2 2 3 2 3 2 2 2 2 2 2 4 2 3 3 2 2 2 2 2 2 2 2|
Lateral Wall, Fibrosis | 1 2 1 1 1 1 1 1 1 1 2 1 1 2 1 2 1 1 2 2 1 1 2 1|
Lateral Wall, Hyperplasia | 2 2 2 2 3 2 2 2 2 2 2 2 2 2 1 3 2 2 2 2 2 2 2 2|
Lateral Wall, Inflammation, | |
Suppurative | 1 2 1 1 1 2 1 1 1 1 2 1 1 2 1 1 2 1 1 2 2 1 1 2 1|
Lateral Wall, Metaplasia, Squamous | 1 1 2 1 1 1 1 2 3 1 1 2 3|
Lateral Wall, Necrosis | 1 |
Olfactory Epithelium, Atrophy | 3 3 1 3 2 1 2 1 4 3 1 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Squamous | 1 |
Mineralization | |
Necrosis | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glomerulosclerosis | 3 |
Hydronephrosis | 2 |
Karyomegaly | |
Metaplasia, Osseous | 2 1 |
Mineralization | |
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 2|
Cortex, Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Urinary Bladder | A + + + + + + + + + + + + + + + + A + + + + A + +|
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
__________________________________________________________________________________________________________________________________
| 9| 7| 7| 8| 9| 4| 9| 7| 8| 6| 8| 8| 4| 8| 9| 7| 6| 9| 9| 9| 8| 5| 6| 6| 9| |
DAY ON TEST | 1| 7| 4| 5| 0| 5| 1| 0| 7| 8| 3| 8| 1| 4| 1| 5| 4| 1| 1| 1| 6| 3| 4| 9| 1| |
| 1| 8| 9| 2| 3| 5| 2| 3| 4| 0| 3| 0| 6| 7| 2| 5| 7| 1| 2| 1| 9| 0| 6| 3| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + M + + + + + + A + + +| 44 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Necrosis | 2 | 1 2.0|
Peyer's Patch, Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 1 2.0|
Basophilic Focus | X | 3 |
Eosinophilic Focus | X X | 3 |
Hematopoietic Cell Proliferation | 2 | 4 1.5|
Inflammation, Chronic | 2 | 1 2.0|
Necrosis | 2 | 3 1.7|
Pigmentation | | 1 1.0|
Bile Duct, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 10 |
Fat, Necrosis | 2 | 4 2.8|
Lymphatic, Angiectasis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Oral Mucosa | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 |
Atrophy | 2 3 | 3 3.0|
Basophilic Focus | X X | 5 |
Inflammation | | 1 2.0|
Duct, Cyst | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 2 1 | 3 1.7|
Necrosis | | 1 3.0|
Epithelium, Hyperplasia | 4 2 1 1 | 6 2.2|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Mineralization | 2 | 1 2.0|
Epithelium, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
__________________________________________________________________________________________________________________________________
| 9| 7| 7| 8| 9| 4| 9| 7| 8| 6| 8| 8| 4| 8| 9| 7| 6| 9| 9| 9| 8| 5| 6| 6| 9| |
DAY ON TEST | 1| 7| 4| 5| 0| 5| 1| 0| 7| 8| 3| 8| 1| 4| 1| 5| 4| 1| 1| 1| 6| 3| 4| 9| 1| |
| 1| 8| 9| 2| 3| 5| 2| 3| 4| 0| 3| 0| 6| 7| 2| 5| 7| 1| 2| 1| 9| 0| 6| 3| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Cardiomyopathy | 1 1 1 1 1 2 2 1 1 1 1 1 1 3 1 2| 36 1.2|
Inflammation, Suppurative | 2 | 1 2.0|
Pigmentation, Hemosiderin | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 1 | 3 1.3|
Hypertrophy | 1 1 1 | 6 1.0|
Capsule, Hyperplasia | 2 | 2 2.5|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 1 1| 4 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + M + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M + M + + + M M M + M + + + + + M + I + + M M +| 29 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Hyperplasia | 2 2 1 4 2 1 2 3 2 1 | 16 1.9|
Pars Intermedia, Hyperplasia | 2 | 1 2.0|
Pars Intermedia, Hypertrophy | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Hyperplasia | 2 1 1 2 1 4 3 4 1 2 2 1 1 1 3 3 2 2| 30 1.9|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + M + + + + + + + + + M + + + + + + +| 42 |
Inflammation, Chronic Active | 2 | 2 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 2.0|
Atrophy | 3 2 2 2 3 4 2 2 2 3 2 3 2 3 3 2 2| 30 2.5|
Cyst | 3 2 3 2 3 2 3 | 16 2.3|
Inflammation, Chronic | | 1 2.0|
Interstitial Cell, Hyperplasia | 3 | 2 2.5|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 | 2 1.0|
Cyst | 2 4 3 3 2 2 4| 9 2.8|
Decidual Reaction | 2 | 1 2.0|
Hydrometra | | 1 3.0|
Inflammation, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
__________________________________________________________________________________________________________________________________
| 9| 7| 7| 8| 9| 4| 9| 7| 8| 6| 8| 8| 4| 8| 9| 7| 6| 9| 9| 9| 8| 5| 6| 6| 9| |
DAY ON TEST | 1| 7| 4| 5| 0| 5| 1| 0| 7| 8| 3| 8| 1| 4| 1| 5| 4| 1| 1| 1| 6| 3| 4| 9| 1| |
| 1| 8| 9| 2| 3| 5| 2| 3| 4| 0| 3| 0| 6| 7| 2| 5| 7| 1| 2| 1| 9| 0| 6| 3| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 | 4 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + | 9 |
Lumbar, Hyperplasia | 2 | 1 2.0|
Renal, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + M + M + + + M + + + + + + + M +| 33 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + I + + + + + + + + + + + + + + + + + + M +| 41 |
Hyperplasia | 2| 3 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + M M + + + + + + + + + + + + + + + + + + +| 44 |
Angiectasis | | 1 3.0|
Hematopoietic Cell Proliferation | 2| 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + + + M M + + M + + + M + + M + + + + + + + + +| 38 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 2 3 2 2 3 2 2| 21 2.3|
Hyperplasia, Lymphoid | 2 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Thymus | M + + + M + M + M M + M + + + M + + + + + + + + +| 33 |
Atrophy | | 1 2.0|
Hyperplasia, Lymphoid | 2 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 4 2 | 3 2.7|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Vulva, Inflammation, Suppurative | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Chondradysplasia | | 1 |
Fibrous Osteodystrophy | 1 2 2 1 1 2 2 1| 14 1.5|
__________________________________________________________________________|____________|
Skeletal Muscle | + + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrocephalus | 1| 1 1.0|
Meninges, Infiltration Cellular | 1 2 | 2 1.5|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
__________________________________________________________________________________________________________________________________
| 9| 7| 7| 8| 9| 4| 9| 7| 8| 6| 8| 8| 4| 8| 9| 7| 6| 9| 9| 9| 8| 5| 6| 6| 9| |
DAY ON TEST | 1| 7| 4| 5| 0| 5| 1| 0| 7| 8| 3| 8| 1| 4| 1| 5| 4| 1| 1| 1| 6| 3| 4| 9| 1| |
| 1| 8| 9| 2| 3| 5| 2| 3| 4| 0| 3| 0| 6| 7| 2| 5| 7| 1| 2| 1| 9| 0| 6| 3| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 1 1 2 1 1 1 1 1 1 2 1 1| 24 1.3|
Inflammation, Suppurative | 1 2 1 3 1 2 1 | 10 1.4|
Necrosis | 1 1 | 2 1.0|
Epiglottis, Hyperplasia | 1 1 1 1 | 4 1.0|
Epiglottis, Metaplasia, Squamous | 1 1 1 1 1 1| 19 1.1|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion, Chronic | 2 4 | 2 3.0|
Hemorrhage | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | 4 4 | 3 3.0|
Alveolar Epithelium, Metaplasia | 3 1 2 2 1 3 2 2 2 2 3 2 3 3 3 3 1 2 3 2 2 1 2 1 2| 50 2.1|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 1 1 3 1 2 1 4 2 2 2 2 2 2 1 2 2 2 1 1 4 2| 45 1.8|
Mediastinum, Necrosis | | 1 2.0|
Perivascular, Infiltration Cellular | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lateral Wall, Degeneration, Hyaline | 2 3 2 2 2 4 2 2 2 2 3 3 4 2 2 3 3 3 3 2 2 4 2 2 2| 50 2.4|
Lateral Wall, Fibrosis | 1 1 1 1 2 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 2 1 1 1| 48 1.2|
Lateral Wall, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2| 47 2.0|
Lateral Wall, Inflammation, | | |
Suppurative | 1 1 1 1 1 2 1 1 1 1 1 1 2 1 1 2 1 1 2 1 1 2 1 1 1| 50 1.3|
Lateral Wall, Metaplasia, Squamous | 1 1 1 2 1 1 1 1 1 1 1 1 2 3 1| 28 1.4|
Lateral Wall, Necrosis | | 1 1.0|
Olfactory Epithelium, Atrophy | 3 2 1 3 2 3 1 2 3 2 2 2 2 2 2 1 3 3 3 3| 40 2.2|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Metaplasia, Squamous | | 1 1.0|
Mineralization | 2 | 1 2.0|
Necrosis | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Glomerulosclerosis | 3 | 2 3.0|
Hydronephrosis | 2 | 2 2.0|
Karyomegaly | 1 2 | 2 1.5|
Metaplasia, Osseous | 1 1 1 | 5 1.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
__________________________________________________________________________________________________________________________________
| 9| 7| 7| 8| 9| 4| 9| 7| 8| 6| 8| 8| 4| 8| 9| 7| 6| 9| 9| 9| 8| 5| 6| 6| 9| |
DAY ON TEST | 1| 7| 4| 5| 0| 5| 1| 0| 7| 8| 3| 8| 1| 4| 1| 5| 4| 1| 1| 1| 6| 3| 4| 9| 1| |
| 1| 8| 9| 2| 3| 5| 2| 3| 4| 0| 3| 0| 6| 7| 2| 5| 7| 1| 2| 1| 9| 0| 6| 3| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Mineralization | 3 | 1 3.0|
Nephropathy | 1 1 1 1 1 2 1 1 1 1 1 1 2| 30 1.1|
Cortex, Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + I + + + + + + + + + + + +| 46 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
_____________________________________________________________________________________________________________________
| 9| 7| 8| 7| 7| 4| 8| 5| 8| 8| 3| 8| 7| 4| 9| 9| 9| 0| 9| 8| 9| 7| 6| 6| 8|
DAY ON TEST | 1| 8| 8| 7| 0| 5| 0| 7| 0| 0| 9| 0| 6| 8| 1| 0| 1| 9| 1| 4| 1| 4| 9| 9| 4|
| 2| 1| 3| 8| 1| 4| 7| 8| 7| 5| 1| 7| 7| 2| 1| 1| 2| 5| 2| 5| 1| 9| 3| 4| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Gallbladder | + A + + + + + A + + A + + + + + + A M + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + A + + + + + A + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + A + + + + + A + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + A + + + + + A + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + + + A + + + + + + + + + A + + + + + + +|
Necrosis | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + A + + + + + + + + + A + + + + + A +|
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + M + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + A + + + + + + +|
Basophilic Focus | X X |
Clear Cell Focus | |
Degeneration, Fatty | 2 |
Eosinophilic Focus | X X X X |
Hematopoietic Cell Proliferation | 3 |
Hepatodiaphragmatic Nodule | |
Inflammation, Chronic | 1 3 |
Necrosis | 1 1 3 |
Bile Duct, Cyst | 4 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + M + + + + + + +|
Atrophy | 2 3 |
Basophilic Focus | X |
Vacuolization Cytoplasmic | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + A + + + + + + +|
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + A + + + + + + +|
Inflammation, Acute | 2 |
Necrosis | 1 |
Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 1 1 1 1 2 1 2 1 1 2 2 1 1 1 1 1 1 3|
Inflammation, Suppurative | 2 |
Necrosis | |
Atrium, Thrombosis | 4|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + A + + + + + + + + + A I + + + + + +|
Hyperplasia | 1 1 2 |
Hypertrophy | 1 1 2 1 1 1 3 1 1 |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
_____________________________________________________________________________________________________________________
| 9| 7| 8| 7| 7| 4| 8| 5| 8| 8| 3| 8| 7| 4| 9| 9| 9| 0| 9| 8| 9| 7| 6| 6| 8|
DAY ON TEST | 1| 8| 8| 7| 0| 5| 0| 7| 0| 0| 9| 0| 6| 8| 1| 0| 1| 9| 1| 4| 1| 4| 9| 9| 4|
| 2| 1| 3| 8| 1| 4| 7| 8| 7| 5| 1| 7| 7| 2| 1| 1| 2| 5| 2| 5| 1| 9| 3| 4| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Capsule, Hyperplasia | 2 2 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + A + + + + + + + + + A + + + + + + +|
Hyperplasia | 2 4|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + M + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + M + + A + M + + + + +|
__________________________________________________________________________|
Pituitary Gland | + M + + + + + + + + + + + + + + + A + I + + + + +|
Pars Distalis, Hyperplasia | |
Pars Intermedia, Hyperplasia | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + A + + + + + + +|
Follicular Cell, Hyperplasia | 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + A + + + + + + +|
Granuloma Sperm | |
Inflammation | |
__________________________________________________________________________|
Penis | + + |
Inflammation, Suppurative | 2 3 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + A + + + + + + +|
Cyst | 2 3 4 3|
Inflammation, Chronic Active | 3 4 4 4 3 4|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + A + + + + + M +|
Hyperplasia | 1 |
Inflammation, Suppurative | 3 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + A + + + + + + +|
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 3 3 1 3 1|
Interstitial Cell, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + A + + + + + + +|
Hyperplasia | 2 2 |
Necrosis | 4 |
__________________________________________________________________________|
Lymph Node | + + |
Iliac, Infiltration Cellular, Plasma | |
Cell | 4 |
__________________________________________________________________________|
Lymph Node, Bronchial | + M + M M + + + M M + + + + M M + A + M M M M + +|
__________________________________________________________________________|
Lymph Node, Mandibular | M M M M + + + + + I + + + M + + + M + + + + M + M|
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + A + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
_____________________________________________________________________________________________________________________
| 9| 7| 8| 7| 7| 4| 8| 5| 8| 8| 3| 8| 7| 4| 9| 9| 9| 0| 9| 8| 9| 7| 6| 6| 8|
DAY ON TEST | 1| 8| 8| 7| 0| 5| 0| 7| 0| 0| 9| 0| 6| 8| 1| 0| 1| 9| 1| 4| 1| 4| 9| 9| 4|
| 2| 1| 3| 8| 1| 4| 7| 8| 7| 5| 1| 7| 7| 2| 1| 1| 2| 5| 2| 5| 1| 9| 3| 4| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Angiectasis | 2 1 3|
Congestion | 4 |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + M + + + + + + + M M + + + + + A + + + M + + +|
Hyperplasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + M + + + + + + +|
Angiectasis | 2 |
Hematopoietic Cell Proliferation | 2 3 3 2 2 2 2 2 2|
Hyperplasia, Lymphoid | 2 |
Pigmentation, Melanin | 2 |
__________________________________________________________________________|
Thymus | + + M + + M M + M + + M + + M M + A + M + + + M M|
Atrophy | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + A + + + + + + +|
Inflammation, Chronic Active | |
Prepuce, Inflammation, Chronic Active| 4 4 4 4 |
Subcutaneous Tissue, Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | |
__________________________________________________________________________|
Skeletal Muscle | + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + A + + + + + + +|
Developmental Malformation | X |
Hemorrhage | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + A + + + + + + +|
Hyperplasia | 1 1 1 1 |
Inflammation, Acute | 1 |
Inflammation, Chronic | |
Inflammation, Chronic Active | 1 |
Inflammation, Suppurative | 2|
Epiglottis, Hyperplasia | |
Epiglottis, Metaplasia, Squamous | 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + A + + + + + + +|
Angiectasis | 1 |
Hemorrhage | 1 |
Alveolar Epithelium, Hyperplasia | 4 4 1 |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
_____________________________________________________________________________________________________________________
| 9| 7| 8| 7| 7| 4| 8| 5| 8| 8| 3| 8| 7| 4| 9| 9| 9| 0| 9| 8| 9| 7| 6| 6| 8|
DAY ON TEST | 1| 8| 8| 7| 0| 5| 0| 7| 0| 0| 9| 0| 6| 8| 1| 0| 1| 9| 1| 4| 1| 4| 9| 9| 4|
| 2| 1| 3| 8| 1| 4| 7| 8| 7| 5| 1| 7| 7| 2| 1| 1| 2| 5| 2| 5| 1| 9| 3| 4| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolus, Infiltration Cellular, | |
Histiocyte | |
Perivascular, Infiltration Cellular | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + A + + + + + + +|
Lateral Wall, Degeneration, Hyaline | |
Lateral Wall, Hyperplasia | |
Lateral Wall, Inflammation, | |
Suppurative | |
Lateral Wall, Metaplasia, Squamous | |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 2 |
Olfactory Epithelium, Atrophy | 2 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + A + + + + + + +|
Hyperplasia | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Inflammation | 4 |
__________________________________________________________________________|
Harderian Gland | + + + + + |
__________________________________________________________________________|
Lacrimal Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + A + + + + + + +|
Cyst | 2 |
Infarct | 4 |
Nephropathy | 2 2 1 1 1 1 1 1 2 1 1 1 1 1 1 2 3|
Papilla, Inflammation, Suppurative | 2 2 3 |
Papilla, Necrosis | |
Pelvis, Dilatation | 3 3 |
Renal Tubule, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + A + + + + M + + + + A + + + + + + +|
Inflammation, Chronic Active | 4 4 |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
__________________________________________________________________________________________________________________________________
| 5| 3| 9| 3| 9| 8| 9| 8| 8| 9| 9| 6| 7| 8| 7| 9| 7| 7| 9| 9| 6| 8| 3| 9| 9| |
DAY ON TEST | 2| 8| 1| 2| 1| 8| 1| 4| 1| 1| 1| 0| 2| 1| 9| 1| 0| 2| 1| 1| 6| 6| 9| 1| 0| |
| 7| 7| 2| 8| 1| 2| 1| 0| 7| 1| 2| 5| 1| 0| 1| 1| 7| 2| 2| 1| 5| 9| 2| 1| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + M A + + + + + + + + + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + A + A + + + + + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A + + + + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + A + + + + A + + + + + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + A + + + + A + + + + + + + + + + + + + + + +| 44 |
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + A + + + + A + + + + + + + + + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + A + + + + A + + + + + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Basophilic Focus | | 2 |
Clear Cell Focus | X | 1 |
Degeneration, Fatty | 2 | 2 2.0|
Eosinophilic Focus | X X X X X X | 10 |
Hematopoietic Cell Proliferation | 2 | 2 2.5|
Hepatodiaphragmatic Nodule | X | 1 |
Inflammation, Chronic | | 2 2.0|
Necrosis | | 3 1.7|
Bile Duct, Cyst | | 1 4.0|
__________________________________________________________________________|____________|
Mesentery | + | 3 |
Fat, Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 2 | 3 2.3|
Basophilic Focus | | 1 |
Vacuolization Cytoplasmic | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Epithelium, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Acute | | 1 2.0|
Necrosis | 1 | 2 1.0|
Epithelium, Hyperplasia | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 1 1 1 2 1 1 2 2 1 1 1 1 2 1 1 2 1| 40 1.3|
Inflammation, Suppurative | 1 | 2 1.5|
Necrosis | 3 | 1 3.0|
Atrium, Thrombosis | 4 | 2 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
__________________________________________________________________________________________________________________________________
| 5| 3| 9| 3| 9| 8| 9| 8| 8| 9| 9| 6| 7| 8| 7| 9| 7| 7| 9| 9| 6| 8| 3| 9| 9| |
DAY ON TEST | 2| 8| 1| 2| 1| 8| 1| 4| 1| 1| 1| 0| 2| 1| 9| 1| 0| 2| 1| 1| 6| 6| 9| 1| 0| |
| 7| 7| 2| 8| 1| 2| 1| 0| 7| 1| 2| 5| 1| 0| 1| 1| 7| 2| 2| 1| 5| 9| 2| 1| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Hyperplasia | 2 2 2 2 1 2 | 9 1.7|
Hypertrophy | 1 1 1 2 1 1 1 1 1 3 1 | 20 1.3|
Capsule, Hyperplasia | 2 2 2 2 3 | 9 2.1|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | | 2 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 4 1 2 3 | 4 2.5|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + M + M + + + + + + + M + + + + M +| 43 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Pars Distalis, Hyperplasia | 1 | 1 1.0|
Pars Intermedia, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Follicular Cell, Hyperplasia | 2 3 1 4 1 1 2 1 1 1 | 18 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Granuloma Sperm | 3 | 1 3.0|
Inflammation | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Penis | + + | 4 |
Inflammation, Suppurative | 2 | 3 2.3|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 3 4 2 3 2 4 3 | 11 3.0|
Inflammation, Chronic Active | 3 2 3 1 3 3 2 3 2| 15 2.9|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | | 1 1.0|
Inflammation, Suppurative | 1 | 3 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + M + + + + + + + + + +| 48 |
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 4 3 4 2| 11 2.4|
Interstitial Cell, Hyperplasia | | 2 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
__________________________________________________________________________________________________________________________________
| 5| 3| 9| 3| 9| 8| 9| 8| 8| 9| 9| 6| 7| 8| 7| 9| 7| 7| 9| 9| 6| 8| 3| 9| 9| |
DAY ON TEST | 2| 8| 1| 2| 1| 8| 1| 4| 1| 1| 1| 0| 2| 1| 9| 1| 0| 2| 1| 1| 6| 6| 9| 1| 0| |
| 7| 7| 2| 8| 1| 2| 1| 0| 7| 1| 2| 5| 1| 0| 1| 1| 7| 2| 2| 1| 5| 9| 2| 1| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 3 | 3 2.3|
Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | | 2 |
Iliac, Infiltration Cellular, Plasma | | |
Cell | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + M + + M M + + + + M M + M M + + M M M + + M M| 26 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + M + M M + M + + + + + + + M + M + M + +| 34 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + M + + + + + + + + + + + + + + + + + + + + +| 48 |
Angiectasis | | 3 2.0|
Congestion | | 1 4.0|
Hematopoietic Cell Proliferation | 4 | 2 3.0|
Hyperplasia | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M + M M + + + + + M + M + + + + + + + M + M + M| 37 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | | 1 2.0|
Hematopoietic Cell Proliferation | 2 2 2 2 2 | 14 2.1|
Hyperplasia, Lymphoid | 4 | 2 3.0|
Pigmentation, Melanin | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + M M M + M + M + + + I + M M + + M + + M| 29 |
Atrophy | 3 2 3 | 4 2.8|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | 2| 1 2.0|
Prepuce, Inflammation, Chronic Active| 3 4 4 3 2 4 4 | 11 3.6|
Subcutaneous Tissue, Hemorrhage | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 1 | 1 1.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Developmental Malformation | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
__________________________________________________________________________________________________________________________________
| 5| 3| 9| 3| 9| 8| 9| 8| 8| 9| 9| 6| 7| 8| 7| 9| 7| 7| 9| 9| 6| 8| 3| 9| 9| |
DAY ON TEST | 2| 8| 1| 2| 1| 8| 1| 4| 1| 1| 1| 0| 2| 1| 9| 1| 0| 2| 1| 1| 6| 6| 9| 1| 0| |
| 7| 7| 2| 8| 1| 2| 1| 0| 7| 1| 2| 5| 1| 0| 1| 1| 7| 2| 2| 1| 5| 9| 2| 1| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Hemorrhage | | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 4 1.0|
Inflammation, Acute | | 1 1.0|
Inflammation, Chronic | 1 | 1 1.0|
Inflammation, Chronic Active | 1 1 1 1 1| 6 1.0|
Inflammation, Suppurative | | 1 2.0|
Epiglottis, Hyperplasia | 1 | 1 1.0|
Epiglottis, Metaplasia, Squamous | 1 | 2 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | | 1 1.0|
Hemorrhage | | 1 1.0|
Alveolar Epithelium, Hyperplasia | 3 3 3 1 4 3 2| 10 2.8|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 4 3 | 3 3.0|
Perivascular, Infiltration Cellular | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lateral Wall, Degeneration, Hyaline | 1 2 | 2 1.5|
Lateral Wall, Hyperplasia | 1 1 | 2 1.0|
Lateral Wall, Inflammation, | | |
Suppurative | 1 | 1 1.0|
Lateral Wall, Metaplasia, Squamous | 1 | 1 1.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 2 2.0|
Olfactory Epithelium, Atrophy | 2 2 | 4 1.8|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 3 |
Inflammation | 3 | 2 3.5|
__________________________________________________________________________|____________|
Harderian Gland | + + | 7 |
__________________________________________________________________________|____________|
Lacrimal Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 2 2 2 | 4 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
__________________________________________________________________________________________________________________________________
| 5| 3| 9| 3| 9| 8| 9| 8| 8| 9| 9| 6| 7| 8| 7| 9| 7| 7| 9| 9| 6| 8| 3| 9| 9| |
DAY ON TEST | 2| 8| 1| 2| 1| 8| 1| 4| 1| 1| 1| 0| 2| 1| 9| 1| 0| 2| 1| 1| 6| 6| 9| 1| 0| |
| 7| 7| 2| 8| 1| 2| 1| 0| 7| 1| 2| 5| 1| 0| 1| 1| 7| 2| 2| 1| 5| 9| 2| 1| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Infarct | | 1 4.0|
Nephropathy | 1 2 1 1 2 1 2 1 1 1 3 1 2 1 1 1 1 2 1 1 2 1 2| 40 1.4|
Papilla, Inflammation, Suppurative | | 3 2.3|
Papilla, Necrosis | 2 | 1 2.0|
Pelvis, Dilatation | | 2 3.0|
Renal Tubule, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Inflammation, Chronic Active | | 2 4.0|
Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
_____________________________________________________________________________________________________________________
| 9| 7| 8| 6| 9| 6| 6| 6| 4| 9| 8| 9| 9| 8| 5| 7| 7| 6| 7| 7| 9| 7| 9| 6| 9|
DAY ON TEST | 1| 9| 6| 9| 1| 1| 9| 5| 7| 1| 2| 1| 1| 0| 6| 9| 0| 3| 7| 2| 1| 2| 0| 7| 1|
| 2| 8| 9| 3| 1| 0| 3| 1| 1| 1| 3| 1| 2| 4| 8| 9| 9| 2| 3| 1| 2| 2| 1| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + A + + + + M + + + + + + + + A + + + A +|
Inflammation, Suppurative | |
Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + A + + + + + + + + + + + + + A + + + A +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A + + + + + + + + + + + + + A + + + A +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + + + + + + + + + + + + + A + + + A +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + + + + + + + + + + A + A + + + A +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + + + + + + + + + + + + + A + + + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Degeneration, Fatty | 3 |
Eosinophilic Focus | X X X X X |
Hematopoietic Cell Proliferation | 2 |
Inflammation, Chronic | |
Necrosis | 3 1 2 1|
Bile Duct, Cyst | |
Centrilobular, Necrosis | 2 |
__________________________________________________________________________|
Mesentery | + + +|
Fat, Necrosis | 3 |
__________________________________________________________________________|
Oral Mucosa | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + A +|
Atrophy | 1 4 |
Duct, Cyst | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + A +|
Inflammation, Suppurative | 1 |
Epithelium, Hyperplasia | 1 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + A + + + A +|
Inflammation, Acute | 3 |
Mineralization | 2 |
Necrosis | 2 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 2 1 1 1 2 1 1 1 2|
Mineralization | 1 |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + A +|
Hyperplasia | 2 1 2 2 2 2 2 1|
Hypertrophy | 1 2 1 1 1 1 1 2 1 1 |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
_____________________________________________________________________________________________________________________
| 9| 7| 8| 6| 9| 6| 6| 6| 4| 9| 8| 9| 9| 8| 5| 7| 7| 6| 7| 7| 9| 7| 9| 6| 9|
DAY ON TEST | 1| 9| 6| 9| 1| 1| 9| 5| 7| 1| 2| 1| 1| 0| 6| 9| 0| 3| 7| 2| 1| 2| 0| 7| 1|
| 2| 8| 9| 3| 1| 0| 3| 1| 1| 1| 3| 1| 2| 4| 8| 9| 9| 2| 3| 1| 2| 2| 1| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Capsule, Hyperplasia | 2 2 2 2 3 2 2 2|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + M + + + + + + + + A +|
Hyperplasia | 2 |
Thrombosis | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + A +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | M M M M M + + + M + + + M + + + + + + M + + M M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
Pars Distalis, Hyperplasia | 1 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + I + + + + + + + + + + + + + + + + A +|
Follicular Cell, Hyperplasia | 1 1 1 3 1 1 2 4 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + A +|
Atrophy | |
Granuloma Sperm | 4 |
Inflammation, Chronic | 4 |
__________________________________________________________________________|
Penis | + + |
Inflammation, Suppurative | 3 2 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + A +|
Cyst | 2 3 3 3 3 2|
Inflammation, Chronic Active | 4 1 4 1 3 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + M + + + + + + + + + A +|
Inflammation, Suppurative | 1 2 3 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + A +|
Atrophy | 3 1 4 1 |
Mineralization | |
Interstitial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + A +|
Hyperplasia | 3 3 |
__________________________________________________________________________|
Lymph Node | +|
Iliac, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Bronchial | M + + + M M M M + + M + M + + M + + + + M M M M +|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + M + + M I + M + M + + M + M + M + + + + M +|
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + M + + + + + + + + + M + + + + + M +|
Congestion | |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
_____________________________________________________________________________________________________________________
| 9| 7| 8| 6| 9| 6| 6| 6| 4| 9| 8| 9| 9| 8| 5| 7| 7| 6| 7| 7| 9| 7| 9| 6| 9|
DAY ON TEST | 1| 9| 6| 9| 1| 1| 9| 5| 7| 1| 2| 1| 1| 0| 6| 9| 0| 3| 7| 2| 1| 2| 0| 7| 1|
| 2| 8| 9| 3| 1| 0| 3| 1| 1| 1| 3| 1| 2| 4| 8| 9| 9| 2| 3| 1| 2| 2| 1| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hemorrhage | |
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + M + + M + + I + + M + M + + M + + + + A +|
Hyperplasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + A +|
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | + M M + M + + + + + + + M M M + + M M + + M M A +|
Atrophy | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 |
Epidermis, Hyperplasia | 1 2 |
Prepuce, Inflammation, Chronic Active| 4 4 4 4 3 4 4 |
Subcutaneous Tissue, Edema | 3 |
Subcutaneous Tissue, Infiltration | |
Cellular, Mast Cell | 2 |
Subcutaneous Tissue, Inflammation, | |
Chronic | 2|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + A +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + A +|
Hyperplasia | 1 2 |
Inflammation, Chronic Active | 1 1 1 1 |
Inflammation, Suppurative | 1 1 |
Epiglottis, Hyperplasia | 1 |
Epiglottis, Metaplasia, Squamous | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + A +|
Inflammation, Chronic, Focal | |
Alveolar Epithelium, Hyperplasia | 2 4 3 4 1|
Alveolar Epithelium, Metaplasia | 1 1 2 1 1 2 2 2 2 2 1 2 1 3 1 2 2 1 1 1 1 2 2|
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 4 2 1 1 1 1 2 1 1 2 1 1 1 1 1 1 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + A +|
Lateral Wall, Degeneration, Hyaline | 1 1 1 1 1 2 2 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 2|
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
_____________________________________________________________________________________________________________________
| 9| 7| 8| 6| 9| 6| 6| 6| 4| 9| 8| 9| 9| 8| 5| 7| 7| 6| 7| 7| 9| 7| 9| 6| 9|
DAY ON TEST | 1| 9| 6| 9| 1| 1| 9| 5| 7| 1| 2| 1| 1| 0| 6| 9| 0| 3| 7| 2| 1| 2| 0| 7| 1|
| 2| 8| 9| 3| 1| 0| 3| 1| 1| 1| 3| 1| 2| 4| 8| 9| 9| 2| 3| 1| 2| 2| 1| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Lateral Wall, Fibrosis | 1 1 1 1 1 1 |
Lateral Wall, Hyperplasia | 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1|
Lateral Wall, Inflammation, | |
Suppurative | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Lateral Wall, Metaplasia, Squamous | 1 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
Olfactory Epithelium, Atrophy | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + A +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Inflammation | |
__________________________________________________________________________|
Harderian Gland | + + + |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + A +|
Cyst | 2 |
Hydronephrosis | 2 |
Mineralization | 2 2 |
Nephropathy | 2 2 1 1 2 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1|
Cortex, Inflammation, Suppurative | 2 3 |
Papilla, Inflammation, Suppurative | 2 2 3 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + A +|
Calculus Gross Observation | X X X |
Inflammation, Chronic Active | |
Inflammation, Suppurative | 4 3 4 4 |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
__________________________________________________________________________________________________________________________________
| 7| 3| 6| 7| 6| 8| 7| 9| 8| 8| 9| 4| 7| 8| 8| 7| 8| 8| 8| 9| 9| 8| 7| 7| 6| |
DAY ON TEST | 1| 8| 7| 9| 4| 4| 3| 1| 4| 4| 1| 4| 0| 2| 1| 3| 0| 8| 7| 1| 1| 3| 8| 2| 1| |
| 6| 6| 8| 1| 9| 7| 5| 1| 5| 7| 2| 6| 7| 6| 2| 5| 5| 0| 5| 1| 2| 8| 7| 1| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + A + + + + + + + + + + + + + + + + + + A + + +| 44 |
Inflammation, Suppurative | 1 | 1 1.0|
Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + A + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A + + + + + + + + + + + + + + + + + + A + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A + + + + + + + + + + + + + + + + + + A + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A + + + + + + + + + + + + + + + + + + A + + +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + + + + + + + + + + + + + + + + + + A + + +| 45 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X | 1 |
Degeneration, Fatty | | 1 3.0|
Eosinophilic Focus | X X X X | 9 |
Hematopoietic Cell Proliferation | | 1 2.0|
Inflammation, Chronic | 3 | 1 3.0|
Necrosis | 2 1 1 1 | 8 1.5|
Bile Duct, Cyst | 3 | 1 3.0|
Centrilobular, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 3 |
Fat, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Oral Mucosa | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 4 | 3 3.0|
Duct, Cyst | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 3 | 2 2.0|
Epithelium, Hyperplasia | 3 4 | 4 2.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + + A + + + + + + + + + + + + + + + + + + + + + +| 47 |
Inflammation, Acute | | 1 3.0|
Mineralization | | 1 2.0|
Necrosis | 1 | 3 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 2 1 1| 40 1.2|
Mineralization | | 1 1.0|
Atrium, Thrombosis | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
__________________________________________________________________________________________________________________________________
| 7| 3| 6| 7| 6| 8| 7| 9| 8| 8| 9| 4| 7| 8| 8| 7| 8| 8| 8| 9| 9| 8| 7| 7| 6| |
DAY ON TEST | 1| 8| 7| 9| 4| 4| 3| 1| 4| 4| 1| 4| 0| 2| 1| 3| 0| 8| 7| 1| 1| 3| 8| 2| 1| |
| 6| 6| 8| 1| 9| 7| 5| 1| 5| 7| 2| 6| 7| 6| 2| 5| 5| 0| 5| 1| 2| 8| 7| 1| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 2 2 2 1| 13 1.8|
Hypertrophy | 2 1 1 1 2 2 | 16 1.3|
Capsule, Hyperplasia | 2 2 2 2 | 12 2.1|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 1 | 2 1.5|
Thrombosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + M + M M + + + + + + + + + M M + M + M +| 32 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Hyperplasia | 2 | 4 1.8|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Follicular Cell, Hyperplasia | 1 1 1 1 1 1 3 1 1 1 1 | 20 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 4 | 1 4.0|
Granuloma Sperm | | 1 4.0|
Inflammation, Chronic | | 1 4.0|
__________________________________________________________________________|____________|
Penis | | 2 |
Inflammation, Suppurative | | 2 2.5|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 3 4 3 3 3 | 11 2.9|
Inflammation, Chronic Active | 1 3 4 2 2 4 1 | 13 2.5|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + M + + + + + + +| 47 |
Inflammation, Suppurative | 2 | 5 1.8|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 3 2 2 2 1 2 | 10 2.1|
Mineralization | 2 | 1 2.0|
Interstitial Cell, Hyperplasia | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
__________________________________________________________________________________________________________________________________
| 7| 3| 6| 7| 6| 8| 7| 9| 8| 8| 9| 4| 7| 8| 8| 7| 8| 8| 8| 9| 9| 8| 7| 7| 6| |
DAY ON TEST | 1| 8| 7| 9| 4| 4| 3| 1| 4| 4| 1| 4| 0| 2| 1| 3| 0| 8| 7| 1| 1| 3| 8| 2| 1| |
| 6| 6| 8| 1| 9| 7| 5| 1| 5| 7| 2| 6| 7| 6| 2| 5| 5| 0| 5| 1| 2| 8| 7| 1| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 3 2 2 | 5 2.6|
__________________________________________________________________________|____________|
Lymph Node | + + | 3 |
Iliac, Pigmentation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + + M + M M M + M + M + M + + M + + + M + M +| 27 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + M + + + + + M + + + M + M M M + M M + + + +| 31 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + M + + + + + + + + + + + + + + + +| 46 |
Congestion | 3 2 | 2 2.5|
Hemorrhage | 2 | 1 2.0|
Hyperplasia | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + M + + + + + + + + M M + + + + M + + + +| 39 |
Hyperplasia | 3 2 3 2 2 | 5 2.4|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 | 14 2.0|
Hyperplasia, Lymphoid | 2 3 | 2 2.5|
__________________________________________________________________________|____________|
Thymus | M + + + M M M M + M M + M + M + M M + + + + M M +| 26 |
Atrophy | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 4.0|
Epidermis, Hyperplasia | | 2 1.5|
Prepuce, Inflammation, Chronic Active| 4 4 4 4 4 4| 13 3.9|
Subcutaneous Tissue, Edema | | 1 3.0|
Subcutaneous Tissue, Infiltration | | |
Cellular, Mast Cell | | 1 2.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 2 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
__________________________________________________________________________________________________________________________________
| 7| 3| 6| 7| 6| 8| 7| 9| 8| 8| 9| 4| 7| 8| 8| 7| 8| 8| 8| 9| 9| 8| 7| 7| 6| |
DAY ON TEST | 1| 8| 7| 9| 4| 4| 3| 1| 4| 4| 1| 4| 0| 2| 1| 3| 0| 8| 7| 1| 1| 3| 8| 2| 1| |
| 6| 6| 8| 1| 9| 7| 5| 1| 5| 7| 2| 6| 7| 6| 2| 5| 5| 0| 5| 1| 2| 8| 7| 1| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 1 1 1 1 | 7 1.3|
Inflammation, Chronic Active | 1 2 1 | 7 1.1|
Inflammation, Suppurative | 1 2 2 | 5 1.4|
Epiglottis, Hyperplasia | 1 | 2 1.0|
Epiglottis, Metaplasia, Squamous | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic, Focal | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | 4 4 4 | 8 3.3|
Alveolar Epithelium, Metaplasia | 1 1 1 2 1 2 1 1 2 2 1 1 1 1 2 3 1 1 1 2 2 1 1 1 2| 48 1.5|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 3 1 1 3 4 4 3 1 1 1 3 1 4 3 2 3 1 1 1 4 1 | 40 1.8|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + A + + +| 48 |
Lateral Wall, Degeneration, Hyaline | 1 1 1 1 1 1 1 1 1 1 2 2 1 1 1 1 1 1 1 1 1 1 1 1| 48 1.1|
Lateral Wall, Fibrosis | 1 1| 8 1.0|
Lateral Wall, Hyperplasia | 1 1 1 2 1 2 1 1 1 1 1 1 1 1 | 33 1.1|
Lateral Wall, Inflammation, | | |
Suppurative | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 38 1.0|
Lateral Wall, Metaplasia, Squamous | 2 | 2 1.5|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 2 | 2 2.0|
Olfactory Epithelium, Atrophy | 3 3 2 | 4 2.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | +| 1 |
Inflammation | 4| 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + + +| 8 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | | 1 2.0|
Hydronephrosis | | 1 2.0|
Mineralization | | 2 2.0|
Nephropathy | 1 1 2 3 1 1 1 1 1 1 1 2 1 1 1 2 1 1 2 1 1 1 1| 43 1.2|
Cortex, Inflammation, Suppurative | | 2 2.5|
Papilla, Inflammation, Suppurative | 2 2 | 6 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
__________________________________________________________________________________________________________________________________
| 7| 3| 6| 7| 6| 8| 7| 9| 8| 8| 9| 4| 7| 8| 8| 7| 8| 8| 8| 9| 9| 8| 7| 7| 6| |
DAY ON TEST | 1| 8| 7| 9| 4| 4| 3| 1| 4| 4| 1| 4| 0| 2| 1| 3| 0| 8| 7| 1| 1| 3| 8| 2| 1| |
| 6| 6| 8| 1| 9| 7| 5| 1| 5| 7| 2| 6| 7| 6| 2| 5| 5| 0| 5| 1| 2| 8| 7| 1| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Calculus Gross Observation | | 3 |
Inflammation, Chronic Active | 4 | 1 4.0|
Inflammation, Suppurative | 4 | 5 3.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
_____________________________________________________________________________________________________________________
| 9| 9| 6| 7| 9| 8| 6| 4| 7| 6| 8| 9| 8| 6| 7| 9| 7| 9| 8| 5| 6| 8| 5| 5| 7|
DAY ON TEST | 1| 1| 7| 4| 1| 1| 6| 6| 3| 2| 3| 1| 0| 2| 7| 1| 8| 1| 0| 8| 7| 7| 6| 7| 9|
| 1| 2| 7| 9| 2| 9| 5| 9| 2| 8| 8| 2| 7| 0| 8| 2| 6| 1| 7| 1| 0| 4| 1| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + A + + + + + A + + + + + + + A + + + + + + A +|
Inflammation, Suppurative | 1 |
Mineralization | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + A + + + + M + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + M + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + A + + + + + A + A + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + A + + + + + M A A + + + + + A + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + A + A + + + + + A + + + + + + + +|
Peyer's Patch, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + + + A A A + + + + + A + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Basophilic Focus | |
Degeneration, Fatty | |
Eosinophilic Focus | X |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X |
Infiltration Cellular, Mast Cell | 2 |
Inflammation, Chronic | |
Necrosis | 4 1 |
Bile Duct, Cyst | 2 2 |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + + + + |
Artery, Inflammation, Chronic Active | 4 |
Fat, Necrosis | 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Cytoplasmic Alteration | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Infiltration Cellular, Mast Cell | 1 |
Necrosis | 1 1 |
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 2 |
Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
_____________________________________________________________________________________________________________________
| 9| 9| 6| 7| 9| 8| 6| 4| 7| 6| 8| 9| 8| 6| 7| 9| 7| 9| 8| 5| 6| 8| 5| 5| 7|
DAY ON TEST | 1| 1| 7| 4| 1| 1| 6| 6| 3| 2| 3| 1| 0| 2| 7| 1| 8| 1| 0| 8| 7| 7| 6| 7| 9|
| 1| 2| 7| 9| 2| 9| 5| 9| 2| 8| 8| 2| 7| 0| 8| 2| 6| 1| 7| 1| 0| 4| 1| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Necrosis | |
Artery, Inflammation, Chronic Active | 2 |
Atrium, Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 2 2|
Hypertrophy | 2 1 1 1 |
Capsule, Hyperplasia | 3 4 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + M + M + M M + M M + + + + M + I M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + I + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 3 |
Pars Intermedia, Hyperplasia | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 2 2 3 4 2 1 2 3 2 1 1 1 2 1 2 1 1 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 |
__________________________________________________________________________|
Penis | + + + + + + |
Inflammation, Suppurative | 2 1 3 1 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
Cyst | 3 3 2 |
Hyperplasia | 4 |
Inflammation, Chronic Active | 3 4 |
__________________________________________________________________________|
Prostate | + + + + + + + M + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 2 2 |
Artery, Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Mineralization | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
_____________________________________________________________________________________________________________________
| 9| 9| 6| 7| 9| 8| 6| 4| 7| 6| 8| 9| 8| 6| 7| 9| 7| 9| 8| 5| 6| 8| 5| 5| 7|
DAY ON TEST | 1| 1| 7| 4| 1| 1| 6| 6| 3| 2| 3| 1| 0| 2| 7| 1| 8| 1| 0| 8| 7| 7| 6| 7| 9|
| 1| 2| 7| 9| 2| 9| 5| 9| 2| 8| 8| 2| 7| 0| 8| 2| 6| 1| 7| 1| 0| 4| 1| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia | 4 |
Hyperplasia, Megakaryocyte | |
Hyperplasia | 2 3 |
Infiltration Cellular, Mast Cell | 4 |
__________________________________________________________________________|
Lymph Node | + + +|
Congestion | |
Iliac, Hyperplasia | 2 2 |
Renal, Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | M M M M + + M + + M + + + + M + M + M + M M + M M|
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + M + + M + M + M + + M + + + + M + + + + + M|
Infiltration Cellular, Mast Cell | 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + M + + + + M I + +|
Angiectasis | 2 |
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + M + + + M + + + + + + + M +|
Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hematopoietic Cell Proliferation | 2 2 1 2 2 2 |
Hyperplasia, Lymphoid | |
Infiltration Cellular, Mast Cell | 4 |
__________________________________________________________________________|
Thymus | M M M + + M M + M + M + M + M M M + M M M + M I +|
Atrophy | 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M I|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Prepuce, Inflammation, Chronic Active| 4 4 4 3 4 4 4 4 4 3 4 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | |
Artery, Inflammation, Chronic Active | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 1 1 1 1 1 1 1 |
Inflammation, Chronic Active | 1 1 1 1|
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
_____________________________________________________________________________________________________________________
| 9| 9| 6| 7| 9| 8| 6| 4| 7| 6| 8| 9| 8| 6| 7| 9| 7| 9| 8| 5| 6| 8| 5| 5| 7|
DAY ON TEST | 1| 1| 7| 4| 1| 1| 6| 6| 3| 2| 3| 1| 0| 2| 7| 1| 8| 1| 0| 8| 7| 7| 6| 7| 9|
| 1| 2| 7| 9| 2| 9| 5| 9| 2| 8| 8| 2| 7| 0| 8| 2| 6| 1| 7| 1| 0| 4| 1| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Suppurative | 2 1 |
Epiglottis, Hyperplasia | 1 1 |
Epiglottis, Metaplasia, Squamous | 1 1 1 1 1 1 2 1|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | 4 |
Alveolar Epithelium, Metaplasia | 2 3 4 2 2 3 3 2 2 3 2 2 2 3 1 3 2 2 2 2 3 2 3|
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 1 3 1 1 2 2 4 1 2 1 1 1 4 2 2 1 2 1 1|
Bronchiole, Metaplasia | 1 |
Bronchiole, Necrosis | 1 |
Perivascular, Infiltration Cellular | 2 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lateral Wall, Degeneration, Hyaline | 3 3 2 1 2 2 2 3 2 2 3 3 2 2 3 2 2 3 2 3 2 2 3 3 3|
Lateral Wall, Fibrosis | 1 1 1 2 1 1 2 1 2 1 1 1 1 1 1 1 2 2 1 2 2 1|
Lateral Wall, Hyperplasia | 1 2 2 2 1 1 3 2 2 2 1 2 2 2 2 2 2 2 1 1 1 2 2|
Lateral Wall, Inflammation, | |
Suppurative | 1 1 2 2 1 1 1 1 1 1 1 1 1 1 2 1 1 2 1 1 2 1 2|
Lateral Wall, Metaplasia, Squamous | 1 1 2 2 1 1 1 1 1 1 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
Olfactory Epithelium, Atrophy | 2 3 2 1 2 1 2 2 3 2 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Squamous | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Inflammation | |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 1 |
Infarct | |
Nephropathy | 1 1 1 1 1 2 1 1 2 1 1 2 1 1 1 1|
Cortex, Inflammation, Suppurative | 2 2 2 |
Papilla, Inflammation, Suppurative | 1 2 2 1 1 |
Pelvis, Dilatation | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + A + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 |
Inflammation, Suppurative | 2 4 4 1 |
Transitional Epithelium, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
__________________________________________________________________________________________________________________________________
| 8| 2| 6| 6| 9| 9| 5| 8| 6| 8| 4| 9| 7| 6| 9| 8| 9| 7| 8| 6| 6| 8| 4| 9| 7| |
DAY ON TEST | 3| 9| 1| 2| 1| 1| 5| 0| 8| 1| 3| 1| 4| 7| 1| 7| 1| 3| 2| 0| 7| 7| 0| 1| 1| |
| 2| 7| 6| 3| 2| 2| 0| 8| 5| 2| 5| 1| 1| 7| 2| 7| 1| 0| 8| 9| 8| 5| 8| 2| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | A + + + + + A + + + + + + A + + + + + + A + A + A| 40 |
Inflammation, Suppurative | 1 | 2 1.0|
Mineralization | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | A + + + + + A + + + + + + + + + + + + + A + A + A| 43 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | A + + + + + + + + + + + + + + + + + + + A + A + A| 44 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + + + + A A + + + + + + + + + + + + A + A + A| 40 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + A A + + A + + + + + + + + + A + A + A| 38 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + A + + + A + + + + + + + + + A + A + A| 41 |
Peyer's Patch, Hyperplasia | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + + + A + + + + + + + + + + + + + A + A + A| 40 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 1.0|
Basophilic Focus | X X | 2 |
Degeneration, Fatty | 2 2 | 2 2.0|
Eosinophilic Focus | X X | 3 |
Hematopoietic Cell Proliferation | 1 | 1 1.0|
Hepatodiaphragmatic Nodule | | 1 |
Infiltration Cellular, Mast Cell | | 1 2.0|
Inflammation, Chronic | 1 | 1 1.0|
Necrosis | 1 | 3 2.0|
Bile Duct, Cyst | | 2 2.0|
Centrilobular, Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Mesentery | | 4 |
Artery, Inflammation, Chronic Active | | 1 4.0|
Fat, Necrosis | | 2 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 |
Atrophy | 1 | 1 1.0|
Cytoplasmic Alteration | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 1.0|
Infiltration Cellular, Mast Cell | | 1 1.0|
Necrosis | 1 | 3 1.0|
Epithelium, Hyperplasia | 2 1 | 3 1.7|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + A + + + + + + + + + + + + + A + + + +| 48 |
Necrosis | | 1 2.0|
Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Tooth | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
__________________________________________________________________________________________________________________________________
| 8| 2| 6| 6| 9| 9| 5| 8| 6| 8| 4| 9| 7| 6| 9| 8| 9| 7| 8| 6| 6| 8| 4| 9| 7| |
DAY ON TEST | 3| 9| 1| 2| 1| 1| 5| 0| 8| 1| 3| 1| 4| 7| 1| 7| 1| 3| 2| 0| 7| 7| 0| 1| 1| |
| 2| 7| 6| 3| 2| 2| 0| 8| 5| 2| 5| 1| 1| 7| 2| 7| 1| 0| 8| 9| 8| 5| 8| 2| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 1 |
Mineralization | 2 | 1 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 40 1.1|
Necrosis | 1 | 1 1.0|
Artery, Inflammation, Chronic Active | | 1 2.0|
Atrium, Thrombosis | 4 | 2 3.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + M + +| 49 |
Hyperplasia | 2 1 2 2 | 8 2.1|
Hypertrophy | 1 1 1 1 1 2 2 2 1 | 13 1.3|
Capsule, Hyperplasia | 3 2 2 3 2 | 7 2.7|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + M + +| 49 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 |
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M M + M M M + + M M M M M M + + M + M M M| 25 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| 48 |
Pars Distalis, Hyperplasia | 1 1 | 3 1.7|
Pars Intermedia, Hyperplasia | 1 | 2 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Hyperplasia | 1 1 3 2 1 1 1 1 2 1 2 1 2 2 | 32 1.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Penis | + | 7 |
Inflammation, Suppurative | 3 | 5 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 4 2 2 2 2 | 8 2.5|
Hyperplasia | | 1 4.0|
Inflammation, Chronic Active | 2 3 2 3 3 3 2 | 9 2.8|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + M + + + + + + + + + + A| 47 |
Inflammation, Suppurative | | 3 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
__________________________________________________________________________________________________________________________________
| 8| 2| 6| 6| 9| 9| 5| 8| 6| 8| 4| 9| 7| 6| 9| 8| 9| 7| 8| 6| 6| 8| 4| 9| 7| |
DAY ON TEST | 3| 9| 1| 2| 1| 1| 5| 0| 8| 1| 3| 1| 4| 7| 1| 7| 1| 3| 2| 0| 7| 7| 0| 1| 1| |
| 2| 7| 6| 3| 2| 2| 0| 8| 5| 2| 5| 1| 1| 7| 2| 7| 1| 0| 8| 9| 8| 5| 8| 2| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Artery, Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 |
Hyperplasia | 2 | 1 2.0|
Inflammation, Suppurative | 4 | 1 4.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 1 2 4 | 5 2.4|
Mineralization | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 4.0|
Hyperplasia, Megakaryocyte | 2 | 1 2.0|
Hyperplasia | 2 | 3 2.3|
Infiltration Cellular, Mast Cell | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + | 7 |
Congestion | 2 | 1 2.0|
Iliac, Hyperplasia | | 2 2.0|
Renal, Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + M + + + + + M M + + + + + M + + M| 32 |
Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M + + + + M M + + I M M + M M M + + + + M +| 32 |
Infiltration Cellular, Mast Cell | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + M + + + + + + M + A + +| 44 |
Angiectasis | 2 2 2 | 4 2.0|
Hyperplasia | 3 2 | 3 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M + + + + + + M + M + + + + + + + + + + + + + M| 43 |
Hyperplasia | 2 2 | 5 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 | 1 1.0|
Hematopoietic Cell Proliferation | 2 2 3 2 2 2 2 2 4 | 15 2.1|
Hyperplasia, Lymphoid | 2 | 1 2.0|
Infiltration Cellular, Mast Cell | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + + + M + + M + + I + + + + M M + M + M M + I + +| 25 |
Atrophy | 4 3 3 2| 5 3.2|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M + M M M M M + M M M M M M M M M M M M M M M M| 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Prepuce, Inflammation, Chronic Active| 4 4 3 4| 16 3.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
__________________________________________________________________________________________________________________________________
| 8| 2| 6| 6| 9| 9| 5| 8| 6| 8| 4| 9| 7| 6| 9| 8| 9| 7| 8| 6| 6| 8| 4| 9| 7| |
DAY ON TEST | 3| 9| 1| 2| 1| 1| 5| 0| 8| 1| 3| 1| 4| 7| 1| 7| 1| 3| 2| 0| 7| 7| 0| 1| 1| |
| 2| 7| 6| 3| 2| 2| 0| 8| 5| 2| 5| 1| 1| 7| 2| 7| 1| 0| 8| 9| 8| 5| 8| 2| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 1 | 1 1.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrocephalus | 2 | 1 2.0|
Artery, Inflammation, Chronic Active | | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 2 2 1 1 | 15 1.1|
Inflammation, Chronic Active | 2 1 1 | 7 1.1|
Inflammation, Suppurative | 1 2 | 4 1.5|
Epiglottis, Hyperplasia | | 2 1.0|
Epiglottis, Metaplasia, Squamous | 1 1 | 10 1.1|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar Epithelium, Hyperplasia | | 1 4.0|
Alveolar Epithelium, Metaplasia | 2 2 2 2 2 2 2 2 2 3 2 3 1 2 2 2 2 1 3 2 1 2 2 2| 47 2.2|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 3 1 2 2 1 1 1 2 1 4 1 1 2 2 3 1 1 1 3 2 1| 41 1.7|
Bronchiole, Metaplasia | | 1 1.0|
Bronchiole, Necrosis | | 1 1.0|
Perivascular, Infiltration Cellular | 2 | 3 2.3|
__________________________________________________________________________|____________|
Nose | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 |
Lateral Wall, Degeneration, Hyaline | 2 3 3 3 3 2 2 2 2 3 2 2 3 2 2 2 3 2 4 3 3 4 2 2| 49 2.5|
Lateral Wall, Fibrosis | 1 2 1 2 1 1 1 1 2 1 1 1 1 2 1 1 2 1 1 1 1 | 43 1.3|
Lateral Wall, Hyperplasia | 2 1 2 2 2 2 1 2 1 2 2 2 2 2 2 2 2 1 2 3 2 2| 45 1.8|
Lateral Wall, Inflammation, | | |
Suppurative | 1 2 1 2 2 1 1 1 2 1 1 1 1 2 1 1 1 1 1 1 2 2 1| 46 1.3|
Lateral Wall, Metaplasia, Squamous | 1 1 1 1 1 1 2 2 1 1 | 20 1.2|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 2 | 2 2.0|
Olfactory Epithelium, Atrophy | 1 1 1 1 2 2 | 18 1.7|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 |
Metaplasia, Squamous | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56
__________________________________________________________________________________________________________________________________
| 8| 2| 6| 6| 9| 9| 5| 8| 6| 8| 4| 9| 7| 6| 9| 8| 9| 7| 8| 6| 6| 8| 4| 9| 7| |
DAY ON TEST | 3| 9| 1| 2| 1| 1| 5| 0| 8| 1| 3| 1| 4| 7| 1| 7| 1| 3| 2| 0| 7| 7| 0| 1| 1| |
| 2| 7| 6| 3| 2| 2| 0| 8| 5| 2| 5| 1| 1| 7| 2| 7| 1| 0| 8| 9| 8| 5| 8| 2| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
Inflammation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + | 5 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 | 3 1.7|
Infarct | 4 | 1 4.0|
Nephropathy | 2 1 1 2 2 1 1 1 1 1 1 1 1 1 1 2 1 3 1 3 1 | 37 1.3|
Cortex, Inflammation, Suppurative | | 3 2.0|
Papilla, Inflammation, Suppurative | 4 | 6 1.8|
Pelvis, Dilatation | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
Inflammation, Chronic Active | 3 | 2 3.5|
Inflammation, Suppurative | 4| 5 3.0|
Transitional Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
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