TDMS Study 88034-06 Pathology Tables
NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 Facility: Battelle Northwest Chemical CAS #: 10028-15-6 Lock Date: 03/09/93 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Page 1 NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 _____________________________________________________________________________________________________________________ | 7| 8| 8| 8| 6| 9| 4| 5| 8| 9| 7| 7| 9| 9| 5| 8| 7| 7| 8| 8| 5| 7| 8| 8| 8| DAY ON TEST | 7| 0| 6| 4| 2| 1| 0| 5| 4| 1| 9| 9| 1| 1| 3| 4| 4| 4| 6| 4| 2| 2| 0| 7| 2| | 8| 5| 0| 0| 1| 1| 3| 6| 0| 2| 1| 0| 2| 2| 7| 7| 9| 9| 9| 1| 1| 4| 1| 5| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + I + + + + + + + A + + + + +| Inflammation, Suppurative | | Epithelium, Hyperplasia | 2 4 | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + A + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + A + + + + + + + M + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + A + + + + + + + A + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + A + + + + + + + A + + + + +| Necrosis | | Epithelium, Hyperplasia | 2 | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + A + + + + + + + A + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + A + + + + + + + A + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 | Basophilic Focus | X | Clear Cell Focus | X | Eosinophilic Focus | X X | Hematopoietic Cell Proliferation | 2 2 2 | Inflammation, Chronic | | Necrosis | 2 1 2 | Pigmentation | 2 | Vacuolization Cytoplasmic, Focal | 2 | Bile Duct, Cyst | 3 | Bile Duct, Hyperplasia | 1 | Centrilobular, Degeneration | 2 | Centrilobular, Necrosis | 1 | Hepatocyte, Atrophy | | __________________________________________________________________________| Mesentery | + + + + | Artery, Inflammation | | Fat, Inflammation, Chronic | | Fat, Necrosis | 3 4 3 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 4 1 4 4 | Inflammation | 2 | Duct, Cyst | 3 3 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 1 2 | Necrosis | | Epithelium, Hyperplasia | 2 4 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Necrosis | | __________________________________________________________________________| Tooth | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | _____________________________________________________________________________________________________________________| Page 2 NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 _____________________________________________________________________________________________________________________ | 7| 8| 8| 8| 6| 9| 4| 5| 8| 9| 7| 7| 9| 9| 5| 8| 7| 7| 8| 8| 5| 7| 8| 8| 8| DAY ON TEST | 7| 0| 6| 4| 2| 1| 0| 5| 4| 1| 9| 9| 1| 1| 3| 4| 4| 4| 6| 4| 2| 2| 0| 7| 2| | 8| 5| 0| 0| 1| 1| 3| 6| 0| 2| 1| 0| 2| 2| 7| 7| 9| 9| 9| 1| 1| 4| 1| 5| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1| Necrosis | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 | Hyperplasia | 2 2 | Hypertrophy | 1 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 | __________________________________________________________________________| Parathyroid Gland | + + M + + + + + M + + + + + + M + + + + + + + + M| Hyperplasia | | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + I + + + + + + + + + + + + +| Pars Distalis, Hyperplasia | 1 4 1 | Pars Intermedia, Hyperplasia | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Hyperplasia | 1 4 4 2 2 4 1 1 4 1 1 4 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + M + + + + + M + + + + + + +| Inflammation, Chronic Active | 2 | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 | Atrophy | 2 2 3 4 2 3 2 4 3 3 4 2 3 4 4 3 | Cyst | 2 4 2 1 3 1 2 2 2 2 3 | Inflammation, Chronic | | Germinal Epithelium, Hyperplasia | 2 | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Cyst | 4 3| Hydrometra | 4 | Thrombosis | 4 3 | Endometrium, Hyperplasia | | Myometrium, Hyperplasia | 4 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 3 NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 _____________________________________________________________________________________________________________________ | 7| 8| 8| 8| 6| 9| 4| 5| 8| 9| 7| 7| 9| 9| 5| 8| 7| 7| 8| 8| 5| 7| 8| 8| 8| DAY ON TEST | 7| 0| 6| 4| 2| 1| 0| 5| 4| 1| 9| 9| 1| 1| 3| 4| 4| 4| 6| 4| 2| 2| 0| 7| 2| | 8| 5| 0| 0| 1| 1| 3| 6| 0| 2| 1| 0| 2| 2| 7| 7| 9| 9| 9| 1| 1| 4| 1| 5| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Angiectasis | 2 | Hyperplasia | 3 2 2 | __________________________________________________________________________| Lymph Node | + + + + + + + +| Hyperplasia | 2 | Iliac, Angiectasis | 4 3 | Iliac, Hyperplasia | | Lumbar, Congestion | 3 | Renal, Congestion | 3 | __________________________________________________________________________| Lymph Node, Bronchial | + + + + M + + + M + + + + + + + M M + + + + M M M| Hyperplasia | 2 | Infiltration Cellular, Plasma Cell | 2 | Infiltration Cellular, Histiocyte | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + M + + + M + + M + + + M + + + M +| Hyperplasia | | Necrosis | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + M + + + + M + + + + + + + + M + + + + +| Hyperplasia | 3 | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + M + M + + + + + + + + + + + + + + M + + +| Hyperplasia | 2 2 3 | Infiltration Cellular, Histiocyte | 2 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 2 2 3 3 2 2 2 2 2 2 3| Hyperplasia, Lymphoid | 2 4 2 2 | __________________________________________________________________________| Thymus | M + M + M + + + M + M + + + + + M + + + + + + + M| Atrophy | 3 2 | Hyperplasia, Lymphoid | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | 1 2 2 3 1 1 | Fracture | | Cranium, Fracture | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Meninges, Infiltration Cellular | 2 2 | __________________________________________________________________________| Peripheral Nerve | + | _____________________________________________________________________________________________________________________| Page 4 NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 _____________________________________________________________________________________________________________________ | 7| 8| 8| 8| 6| 9| 4| 5| 8| 9| 7| 7| 9| 9| 5| 8| 7| 7| 8| 8| 5| 7| 8| 8| 8| DAY ON TEST | 7| 0| 6| 4| 2| 1| 0| 5| 4| 1| 9| 9| 1| 1| 3| 4| 4| 4| 6| 4| 2| 2| 0| 7| 2| | 8| 5| 0| 0| 1| 1| 3| 6| 0| 2| 1| 0| 2| 2| 7| 7| 9| 9| 9| 1| 1| 4| 1| 5| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM - cont | | | | Degeneration | 2 | __________________________________________________________________________| Spinal Cord | + | Degeneration | 2 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 1 1 1 1 3 1| Inflammation, Chronic Active | 1 1 1 1 | Inflammation, Suppurative | 1 1 1 | Epiglottis, Metaplasia, Squamous | 2 | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 2 | Inflammation, Chronic, Focal | 1 | Alveolar Epithelium, Hyperplasia | 1 | Alveolus, Infiltration Cellular, | | Histiocyte | 2 3 2 2 2 | Perivascular, Infiltration Cellular | 2 3 2 2 2 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Lateral Wall, Fibrosis | 1 | Lateral Wall, Hyperplasia | 1 | Lateral Wall, Inflammation, | | Suppurative | 1 1 1 | Lateral Wall, Metaplasia, Squamous | 1 | Nasolacrimal Duct, Inflammation, | | Suppurative | 1 | Olfactory Epithelium, Atrophy | 1 2 1 1 2 1 | Turbinate, Hyperplasia | | Turbinate, Inflammation, Suppurative | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | + + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis, Focal | 2 | Hydronephrosis | 2| Metaplasia, Osseous | 1 1 1 | Nephropathy | 1 1 1 1 1 1 1 1 1 1| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + A + + + + +| Inflammation, Suppurative | 4 | _____________________________________________________________________________________________________________________| Page 5 NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 __________________________________________________________________________________________________________________________________ | 9| 7| 9| 7| 7| 8| 6| 7| 8| 9| 5| 8| 8| 9| 7| 7| 7| 7| 7| 9| 8| 8| 8| 4| 5| | DAY ON TEST | 1| 2| 1| 2| 7| 8| 7| 9| 8| 1| 2| 4| 6| 1| 5| 9| 9| 1| 2| 1| 5| 2| 2| 0| 4| | | 1| 1| 2| 1| 5| 4| 8| 1| 3| 1| 7| 9| 5| 2| 4| 1| 6| 7| 2| 2| 7| 6| 4| 8| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + A + + + + + + +| 49 | __________________________________________________________________________|____________| Gallbladder | + + + + A + + + + + + A A + + + + A + + + + + A +| 43 | Inflammation, Suppurative | 2 | 1 2.0| Epithelium, Hyperplasia | | 2 3.0| __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + A + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + A + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + A + + + + + + + + + + + + A + + + + + A +| 45 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + A + + + + + + + A + + + + + + + + + + A +| 45 | Necrosis | 1 | 1 1.0| Epithelium, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + A + + + + + + + A + + + + A + + + + + A +| 44 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + A + + + + A + + + + + A +| 45 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + A + + + + + + +| 49 | Angiectasis | | 1 2.0| Basophilic Focus | | 1 | Clear Cell Focus | | 1 | Eosinophilic Focus | X | 3 | Hematopoietic Cell Proliferation | 1 | 4 1.8| Inflammation, Chronic | 2 2 | 2 2.0| Necrosis | 1 2 1 2 | 7 1.6| Pigmentation | 2 | 2 2.0| Vacuolization Cytoplasmic, Focal | | 1 2.0| Bile Duct, Cyst | | 1 3.0| Bile Duct, Hyperplasia | | 1 1.0| Centrilobular, Degeneration | | 1 2.0| Centrilobular, Necrosis | | 1 1.0| Hepatocyte, Atrophy | 2 | 1 2.0| __________________________________________________________________________|____________| Mesentery | + + + + + + + + + | 13 | Artery, Inflammation | 2 | 1 2.0| Fat, Inflammation, Chronic | 2 | 1 2.0| Fat, Necrosis | 2 3 2 2 2 2 | 9 2.6| __________________________________________________________________________|____________| Pancreas | + + + + A + + + + + + + + + + + + A + + + + + + +| 48 | Atrophy | 2 | 5 3.0| Inflammation | 2 | 2 2.0| Duct, Cyst | | 2 3.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + A + + + + + A +| 48 | Inflammation, Suppurative | | 2 1.5| Necrosis | 1 | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 6 NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 __________________________________________________________________________________________________________________________________ | 9| 7| 9| 7| 7| 8| 6| 7| 8| 9| 5| 8| 8| 9| 7| 7| 7| 7| 7| 9| 8| 8| 8| 4| 5| | DAY ON TEST | 1| 2| 1| 2| 7| 8| 7| 9| 8| 1| 2| 4| 6| 1| 5| 9| 9| 1| 2| 1| 5| 2| 2| 0| 4| | | 1| 1| 2| 1| 5| 4| 8| 1| 3| 1| 7| 9| 5| 2| 4| 1| 6| 7| 2| 2| 7| 6| 4| 8| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Epithelium, Hyperplasia | 2 | 3 2.7| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + A + + + + + A +| 48 | Necrosis | 2 | 1 2.0| __________________________________________________________________________|____________| Tooth | + | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 2 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 37 1.1| Necrosis | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + M A + + + + + + +| 48 | Angiectasis | | 1 2.0| Hyperplasia | 1| 3 1.7| Hypertrophy | 1 1 2 1 1 | 6 1.2| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + M A + + + + + + +| 48 | Hyperplasia | 1 1 2 | 4 1.3| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + A M + + + + + + + + + + + A + + + + + + +| 47 | Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Parathyroid Gland | M + + M M + + M + + + + M + + + M M + M + + + M M| 36 | Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + A + + + + + + +| 48 | Pars Distalis, Hyperplasia | 1 2 1 4 1 2 3 1 | 11 1.9| Pars Intermedia, Hyperplasia | 1 | 1 1.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + A + + + + + + +| 49 | Follicular Cell, Hyperplasia | 2 2 2 1 1 1 1 1 3 2 | 22 2.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + M M + + + + + + + + + + M +| 45 | Inflammation, Chronic Active | | 1 2.0| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + A + + + + + + +| 49 | Angiectasis | 2 2 | 3 2.0| Atrophy | 3 2 2 3 4 2 3 3 4 3 3 3 | 28 3.0| Cyst | 2 3 1 3 3 1 3 4 3 3 2 2| 23 2.3| Inflammation, Chronic | 4 | 1 4.0| Germinal Epithelium, Hyperplasia | 2 | 2 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 7 NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 __________________________________________________________________________________________________________________________________ | 9| 7| 9| 7| 7| 8| 6| 7| 8| 9| 5| 8| 8| 9| 7| 7| 7| 7| 7| 9| 8| 8| 8| 4| 5| | DAY ON TEST | 1| 2| 1| 2| 7| 8| 7| 9| 8| 1| 2| 4| 6| 1| 5| 9| 9| 1| 2| 1| 5| 2| 2| 0| 4| | | 1| 1| 2| 1| 5| 4| 8| 1| 3| 1| 7| 9| 5| 2| 4| 1| 6| 7| 2| 2| 7| 6| 4| 8| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + A + + + + + + +| 49 | Angiectasis | 1 2 4 4 | 4 2.8| Cyst | 2 2 3 4 | 6 3.0| Hydrometra | 3 3 | 3 3.3| Thrombosis | | 2 3.5| Endometrium, Hyperplasia | 3 | 1 3.0| Myometrium, Hyperplasia | | 1 4.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + A + + + + + + +| 49 | Angiectasis | 2 | 2 2.0| Hyperplasia | | 3 2.3| __________________________________________________________________________|____________| Lymph Node | + + + + + + + | 15 | Hyperplasia | | 1 2.0| Iliac, Angiectasis | | 2 3.5| Iliac, Hyperplasia | 2 | 1 2.0| Lumbar, Congestion | | 1 3.0| Renal, Congestion | | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Bronchial | M + + + + + + + + + + M M + M + + + M M M + + + +| 36 | Hyperplasia | | 1 2.0| Infiltration Cellular, Plasma Cell | | 1 2.0| Infiltration Cellular, Histiocyte | 2 | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + M + + M + + + + + + + M + + M M A + + + + + M +| 38 | Hyperplasia | 2 2 | 2 2.0| Necrosis | 3 | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + A + + + + + A +| 45 | Hyperplasia | | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + M + + + M + + + + + + M + + + + + + + + + M +| 43 | Hyperplasia | 2 3 | 5 2.4| Infiltration Cellular, Histiocyte | 2 | 2 2.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + A + + + + + + +| 49 | Hematopoietic Cell Proliferation | 2 2 2 2 | 15 2.2| Hyperplasia, Lymphoid | 2 2 | 6 2.3| __________________________________________________________________________|____________| Thymus | + + + M + + M M + M + + + + + M + + M M + M + + +| 35 | Atrophy | | 2 2.5| Hyperplasia, Lymphoid | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 8 NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 __________________________________________________________________________________________________________________________________ | 9| 7| 9| 7| 7| 8| 6| 7| 8| 9| 5| 8| 8| 9| 7| 7| 7| 7| 7| 9| 8| 8| 8| 4| 5| | DAY ON TEST | 1| 2| 1| 2| 7| 8| 7| 9| 8| 1| 2| 4| 6| 1| 5| 9| 9| 1| 2| 1| 5| 2| 2| 0| 4| | | 1| 1| 2| 1| 5| 4| 8| 1| 3| 1| 7| 9| 5| 2| 4| 1| 6| 7| 2| 2| 7| 6| 4| 8| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrous Osteodystrophy | 1 2 1 3 2 2 2 1 1 | 15 1.7| Fracture | X | 1 | Cranium, Fracture | X | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + A + + + + + + +| 49 | Angiectasis | 2 | 1 2.0| Meninges, Infiltration Cellular | | 2 2.0| __________________________________________________________________________|____________| Peripheral Nerve | | 1 | Degeneration | | 1 2.0| __________________________________________________________________________|____________| Spinal Cord | | 1 | Degeneration | | 1 2.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 1 1 1 1 2 1 | 13 1.2| Inflammation, Chronic Active | | 4 1.0| Inflammation, Suppurative | 1 1 | 5 1.0| Epiglottis, Metaplasia, Squamous | 1| 2 1.5| __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | | 1 2.0| Inflammation, Chronic, Focal | | 1 1.0| Alveolar Epithelium, Hyperplasia | 2 2 | 3 1.7| Alveolus, Infiltration Cellular, | | | Histiocyte | | 5 2.2| Perivascular, Infiltration Cellular | 1 | 6 2.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lateral Wall, Fibrosis | | 1 1.0| Lateral Wall, Hyperplasia | | 1 1.0| Lateral Wall, Inflammation, | | | Suppurative | | 3 1.0| Lateral Wall, Metaplasia, Squamous | 1 | 2 1.0| Nasolacrimal Duct, Inflammation, | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 9 NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 __________________________________________________________________________________________________________________________________ | 9| 7| 9| 7| 7| 8| 6| 7| 8| 9| 5| 8| 8| 9| 7| 7| 7| 7| 7| 9| 8| 8| 8| 4| 5| | DAY ON TEST | 1| 2| 1| 2| 7| 8| 7| 9| 8| 1| 2| 4| 6| 1| 5| 9| 9| 1| 2| 1| 5| 2| 2| 0| 4| | | 1| 1| 2| 1| 5| 4| 8| 1| 3| 1| 7| 9| 5| 2| 4| 1| 6| 7| 2| 2| 7| 6| 4| 8| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Suppurative | 2 | 2 1.5| Olfactory Epithelium, Atrophy | 2 2 1 | 9 1.4| Turbinate, Hyperplasia | 2 | 1 2.0| Turbinate, Inflammation, Suppurative | 2 | 1 2.0| __________________________________________________________________________|____________| Trachea | + + + + A + + + + + + + + + + + + A + + + + + + +| 48 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Harderian Gland | + + + | 5 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + A + + + + + + +| 49 | Fibrosis, Focal | | 1 2.0| Hydronephrosis | | 1 2.0| Metaplasia, Osseous | 1 | 4 1.0| Nephropathy | 1 1 1 1 1 1 2 1 1 1 1 1 1 2| 24 1.1| __________________________________________________________________________|____________| Urinary Bladder | + + + + A + + + + + + + + + + + + A + + + + + + +| 47 | Inflammation, Suppurative | | 1 4.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 10 NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 _____________________________________________________________________________________________________________________ | 5| 8| 8| 8| 7| 8| 8| 8| 9| 9| 8| 9| 9| 7| 8| 9| 5| 9| 7| 7| 6| 8| 8| 6| 7| DAY ON TEST | 7| 0| 6| 2| 8| 7| 5| 2| 1| 1| 0| 1| 1| 9| 6| 1| 4| 1| 8| 7| 7| 8| 7| 9| 5| | 1| 5| 3| 1| 5| 7| 5| 6| 2| 2| 7| 2| 2| 2| 1| 2| 4| 1| 4| 5| 8| 0| 5| 1| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + A + M A + + + + + + + + + + M + + + + A A| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + A + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + A + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + A + + A + + + + + + + + + + A + + + + A +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + + A + + + + A A| __________________________________________________________________________| Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + A + + + + A A| __________________________________________________________________________| Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + A + + + + A +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Fatty | | Eosinophilic Focus | X X | Inflammation, Chronic | 2 2 | Necrosis | 4 3 | Pigmentation | | Bile Duct, Cyst | | Centrilobular, Necrosis | 1 | __________________________________________________________________________| Mesentery | + + + | Fat, Necrosis | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + A + + + + + +| Atrophy | | Duct, Cyst | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + M + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 1 2| Necrosis | | Epithelium, Hyperplasia | 1 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute | | Necrosis | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 2 1 1 1 2 1 2 1 1 2 1 1 1 2 1 1 1 1 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 1 | Hypertrophy | 1 1 | Capsule, Hyperplasia | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + A M + + + + +| __________________________________________________________________________| Parathyroid Gland | + M + M M M M M + M + M M + + + + + + M I + + M +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 11 NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 _____________________________________________________________________________________________________________________ | 5| 8| 8| 8| 7| 8| 8| 8| 9| 9| 8| 9| 9| 7| 8| 9| 5| 9| 7| 7| 6| 8| 8| 6| 7| DAY ON TEST | 7| 0| 6| 2| 8| 7| 5| 2| 1| 1| 0| 1| 1| 9| 6| 1| 4| 1| 8| 7| 7| 8| 7| 9| 5| | 1| 5| 3| 1| 5| 7| 5| 6| 2| 2| 7| 2| 2| 2| 1| 2| 4| 1| 4| 5| 8| 0| 5| 1| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Pars Distalis, Hyperplasia | 1 4 3 1 2 4 4 2 | Pars Intermedia, Hyperplasia | 2 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Hyperplasia | 1 4 2 3 2 3 3 2 2 1 3 1 2 3 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + M + + + + + + + + + + + + + + M + + + + + +| __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 | Atrophy | 2 2 2 4 3 2 3 2 2 3 2 2 3 3 2 3 2 2 | Cyst | 4 2 1 4 3 1 2 2 1 1 1 | Necrosis | | Germinal Epithelium, Hyperplasia | 2 2 2 | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 2 | Cyst | 3 | Hemorrhage | 4 | Hydrometra | 2 3 4 2 | Inflammation, Suppurative | | Endometrium, Hyperplasia | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Lymph Node | + + + | __________________________________________________________________________| Lymph Node, Bronchial | + M + M + + + M M + + + M + M M + + + + + M M M M| Hyperplasia | 2 | __________________________________________________________________________| Lymph Node, Mandibular | + + + I + + + + + + + + + + + M + M + + + + + + M| Hematopoietic Cell Proliferation | | Hyperplasia | 2 2 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 2 | Hematopoietic Cell Proliferation | | Hyperplasia | | Infiltration Cellular, Histiocyte | 2 | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + + + + M M M M + + + + + + + M + M| Hyperplasia | 2 2 2 2 2 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 2 2 2 2 4 2 2 3 2 | Hyperplasia, Histiocytic | 2 | Hyperplasia, Lymphoid | 2 2 2 4 2 2 3 | _____________________________________________________________________________________________________________________| Page 12 NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 _____________________________________________________________________________________________________________________ | 5| 8| 8| 8| 7| 8| 8| 8| 9| 9| 8| 9| 9| 7| 8| 9| 5| 9| 7| 7| 6| 8| 8| 6| 7| DAY ON TEST | 7| 0| 6| 2| 8| 7| 5| 2| 1| 1| 0| 1| 1| 9| 6| 1| 4| 1| 8| 7| 7| 8| 7| 9| 5| | 1| 5| 3| 1| 5| 7| 5| 6| 2| 2| 7| 2| 2| 2| 1| 2| 4| 1| 4| 5| 8| 0| 5| 1| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Infiltration Cellular, Histiocyte | 3 | __________________________________________________________________________| Thymus | M + + + + M M + + + + + M + + M + + + + M + M + +| Atrophy | 3| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 4 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | 1 2 2 3 3 2 1 3 2 1 1 1| Cranium, Myelofibrosis | X | Femur, Myelofibrosis | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Meninges, Infiltration Cellular | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 1 1 1 2 2 | Inflammation, Suppurative | 1 | Epiglottis, Metaplasia, Squamous | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 1 2 | Alveolar Epithelium, Hyperplasia | 2 | Alveolar Epithelium, Metaplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1| Alveolus, Infiltration Cellular, | | Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 2 1 1| Mediastinum, Angiectasis | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Artery, Inflammation | | Lateral Wall, Degeneration, Hyaline | 3 2 2 2 2 2 1 2 2 3 2 2 2 2 2 2 3 2 1 2 2 2 2 2 2| Lateral Wall, Fibrosis | 2 1 2 1 1 1 1 1 1 1 1 1 1 | Lateral Wall, Hyperplasia | 2 2 2 2 2 1 2 2 3 2 2 2 2 2 2 2 1 2 2 1 2 2 1| Lateral Wall, Inflammation, | | Suppurative | 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Lateral Wall, Metaplasia, Squamous | 1 | Nasolacrimal Duct, Inflammation, | | Suppurative | 1 | Olfactory Epithelium, Atrophy | 2 3 1 3 1 2 2 2 2 2 2 3 2 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + A + + + + + +| _____________________________________________________________________________________________________________________| Page 13 NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 _____________________________________________________________________________________________________________________ | 5| 8| 8| 8| 7| 8| 8| 8| 9| 9| 8| 9| 9| 7| 8| 9| 5| 9| 7| 7| 6| 8| 8| 6| 7| DAY ON TEST | 7| 0| 6| 2| 8| 7| 5| 2| 1| 1| 0| 1| 1| 9| 6| 1| 4| 1| 8| 7| 7| 8| 7| 9| 5| | 1| 5| 3| 1| 5| 7| 5| 6| 2| 2| 7| 2| 2| 2| 1| 2| 4| 1| 4| 5| 8| 0| 5| 1| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | | Inflammation, Granulomatous | | __________________________________________________________________________| Harderian Gland | + + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Infarct | 4 | Metaplasia, Osseous | | Nephropathy | 2 1 1 1 1 1 1 1 1 1 1 1 1 | Pelvis, Dilatation | 3 | Renal Tubule, Hyperplasia | 4 1 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + A + + + + + +| _____________________________________________________________________________________________________________________| Page 14 NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 __________________________________________________________________________________________________________________________________ | 7| 9| 9| 9| 8| 6| 5| 6| 7| 8| 9| 9| 7| 8| 8| 9| 8| 7| 6| 8| 7| 7| 7| 6| 8| | DAY ON TEST | 2| 1| 1| 1| 7| 2| 9| 1| 6| 5| 1| 1| 8| 8| 8| 1| 7| 5| 2| 1| 6| 9| 2| 1| 5| | | 6| 2| 2| 1| 5| 1| 5| 6| 3| 5| 2| 1| 6| 0| 3| 2| 4| 0| 3| 7| 6| 2| 1| 6| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | + + + + A A + + + + + + A + + + + + + + A A + A +| 38 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + M + + A + + + +| 47 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + A + + + + + + + A + + A +| 43 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + A + + A + + + + M + + + + + M + A + + + +| 41 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + A A + A + + + + + + + + + + + + A + + + +| 42 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + A A + + + + + + A + + + + + + + A + + + +| 43 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Degeneration, Fatty | 2 | 1 2.0| Eosinophilic Focus | X X X X | 6 | Inflammation, Chronic | 2 1 | 4 1.8| Necrosis | 2 | 3 3.0| Pigmentation | 2 2 | 2 2.0| Bile Duct, Cyst | 3 2 | 2 2.5| Centrilobular, Necrosis | | 1 1.0| __________________________________________________________________________|____________| Mesentery | + + | 5 | Fat, Necrosis | 3 2 | 2 2.5| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 | Atrophy | 4 | 1 4.0| Duct, Cyst | 4 | 1 4.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | 2 | 3 1.7| Necrosis | 2 | 1 2.0| Epithelium, Hyperplasia | 1 | 2 1.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 | Inflammation, Acute | 1 | 1 1.0| Necrosis | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 2| 38 1.2| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 | Hyperplasia | | 2 1.5| Hypertrophy | 1 1 1 | 5 1.0| Capsule, Hyperplasia | 3 | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 15 NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 __________________________________________________________________________________________________________________________________ | 7| 9| 9| 9| 8| 6| 5| 6| 7| 8| 9| 9| 7| 8| 8| 9| 8| 7| 6| 8| 7| 7| 7| 6| 8| | DAY ON TEST | 2| 1| 1| 1| 7| 2| 9| 1| 6| 5| 1| 1| 8| 8| 8| 1| 7| 5| 2| 1| 6| 9| 2| 1| 5| | | 6| 2| 2| 1| 5| 1| 5| 6| 3| 5| 2| 1| 6| 0| 3| 2| 4| 0| 3| 7| 6| 2| 1| 6| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 | Hyperplasia | 3 1 | 3 1.7| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + A + + + +| 47 | __________________________________________________________________________|____________| Parathyroid Gland | + M M + M + M + + + + + M + M M + + + + M + + M M| 28 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + M + + + + + + A + + + +| 48 | Pars Distalis, Hyperplasia | 4 3 2 2 1 2 | 14 2.5| Pars Intermedia, Hyperplasia | | 2 2.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 | Follicular Cell, Hyperplasia | 1 1 1 2 2 2 1 3 1| 24 2.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + M + + + + M + + + + + + + + + + + + M M + + +| 44 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + A + I + +| 48 | Angiectasis | 2 | 2 2.0| Atrophy | 2 2 3 2 3 2 2 1 2 3 2 2 4 3 1 | 33 2.4| Cyst | 1 2 2 3 1 2 2 | 18 1.9| Necrosis | 4| 1 4.0| Germinal Epithelium, Hyperplasia | 1 | 4 1.8| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 2 | 3 2.0| Cyst | 2 | 2 2.5| Hemorrhage | | 1 4.0| Hydrometra | 4 | 5 3.0| Inflammation, Suppurative | 2 | 1 2.0| Endometrium, Hyperplasia | 2 1 | 2 1.5| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 | Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Lymph Node | + + + | 6 | __________________________________________________________________________|____________| Lymph Node, Bronchial | M + + I + M M M + + + + + + + + + + + + A + M + +| 32 | Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | M + I + + M + + M + + + + M + + + + + + A + + + +| 40 | Hematopoietic Cell Proliferation | 2 | 1 2.0| Hyperplasia | 2 2 | 4 2.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + A M + + +| 48 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 16 NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 __________________________________________________________________________________________________________________________________ | 7| 9| 9| 9| 8| 6| 5| 6| 7| 8| 9| 9| 7| 8| 8| 9| 8| 7| 6| 8| 7| 7| 7| 6| 8| | DAY ON TEST | 2| 1| 1| 1| 7| 2| 9| 1| 6| 5| 1| 1| 8| 8| 8| 1| 7| 5| 2| 1| 6| 9| 2| 1| 5| | | 6| 2| 2| 1| 5| 1| 5| 6| 3| 5| 2| 1| 6| 0| 3| 2| 4| 0| 3| 7| 6| 2| 1| 6| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Congestion | 2 | 2 2.0| Hematopoietic Cell Proliferation | 2 | 1 2.0| Hyperplasia | 4 | 1 4.0| Infiltration Cellular, Histiocyte | | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mediastinal | + M M + + + M M + + M M + M + + + + + + A + + + +| 36 | Hyperplasia | 2 2 2 3 | 9 2.1| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 2 3 3 | 19 2.3| Hyperplasia, Histiocytic | | 1 2.0| Hyperplasia, Lymphoid | 2 2 | 9 2.3| Infiltration Cellular, Histiocyte | | 1 3.0| __________________________________________________________________________|____________| Thymus | + + I + + + + + M M + + + + + M M + M + A + + + M| 35 | Atrophy | 3 4 | 3 3.3| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | | 1 3.0| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | | 1 4.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrous Osteodystrophy | 1 2 3 2 1 1 | 18 1.8| Cranium, Myelofibrosis | | 1 | Femur, Myelofibrosis | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 | Meninges, Infiltration Cellular | 1 3 | 2 2.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 | Hyperplasia | 1 1 1 1 2| 11 1.3| Inflammation, Suppurative | 1 1 1| 4 1.0| Epiglottis, Metaplasia, Squamous | 1 1| 2 1.0| __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 | Hemorrhage | | 2 1.5| Alveolar Epithelium, Hyperplasia | | 1 2.0| Alveolar Epithelium, Metaplasia | 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 43 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 17 NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 __________________________________________________________________________________________________________________________________ | 7| 9| 9| 9| 8| 6| 5| 6| 7| 8| 9| 9| 7| 8| 8| 9| 8| 7| 6| 8| 7| 7| 7| 6| 8| | DAY ON TEST | 2| 1| 1| 1| 7| 2| 9| 1| 6| 5| 1| 1| 8| 8| 8| 1| 7| 5| 2| 1| 6| 9| 2| 1| 5| | | 6| 2| 2| 1| 5| 1| 5| 6| 3| 5| 2| 1| 6| 0| 3| 2| 4| 0| 3| 7| 6| 2| 1| 6| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Alveolus, Infiltration Cellular, | | | Histiocyte | 1 1 1 2 3 2 2 1 1 1 1 1 1 1 1 1 4| 39 1.3| Mediastinum, Angiectasis | 4 | 1 4.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 | Artery, Inflammation | 2 | 1 2.0| Lateral Wall, Degeneration, Hyaline | 1 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3| 49 2.0| Lateral Wall, Fibrosis | 1 1 1 1 1 1 1 1 1 1| 23 1.1| Lateral Wall, Hyperplasia | 1 2 2 2 2 1 2 2 2 2 1 2 2 2 2 2 1 2 3| 42 1.9| Lateral Wall, Inflammation, | | | Suppurative | 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1| 44 1.0| Lateral Wall, Metaplasia, Squamous | 1 1| 3 1.0| Nasolacrimal Duct, Inflammation, | | | Suppurative | | 1 1.0| Olfactory Epithelium, Atrophy | 2 2 1 2 2 2 2 2 1 1| 23 1.9| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | + | 1 | Inflammation, Granulomatous | 3 | 1 3.0| __________________________________________________________________________|____________| Harderian Gland | + + + | 5 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 | Infarct | | 1 4.0| Metaplasia, Osseous | 1 | 1 1.0| Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 27 1.0| Pelvis, Dilatation | | 1 3.0| Renal Tubule, Hyperplasia | | 2 2.5| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 18 NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 _____________________________________________________________________________________________________________________ | 7| 7| 6| 8| 8| 8| 5| 9| 6| 9| 6| 7| 9| 5| 9| 5| 6| 7| 8| 6| 6| 7| 7| 7| 8| DAY ON TEST | 4| 8| 9| 5| 7| 6| 8| 0| 6| 1| 9| 3| 1| 5| 1| 8| 5| 7| 4| 7| 6| 2| 6| 4| 3| | 1| 6| 6| 5| 4| 9| 8| 3| 0| 1| 7| 5| 1| 9| 2| 6| 1| 4| 7| 8| 5| 2| 7| 9| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | A + + + + + + + I + + + + + + + + A + + + + A + +| __________________________________________________________________________| Intestine Large, Colon | A + + + + + + M + + + + + + + + + A + + + + A + +| __________________________________________________________________________| Intestine Large, Rectum | A + + + + + + + + + + + + + + + + A + + + + A + +| __________________________________________________________________________| Intestine Large, Cecum | A + + + + + + + A + + + + + + + + A + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | A + + + + + + + A + + + + + + + + M + + + + A + +| Necrosis | | Peyer's Patch, Hyperplasia | | __________________________________________________________________________| Intestine Small, Jejunum | A + + + + + + + + + + + + + + + + A + + + + A + +| __________________________________________________________________________| Intestine Small, Ileum | A + + + + + + + A + + + + + + + + A + + + + A + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Basophilic Focus | X X | Eosinophilic Focus | X | Hematopoietic Cell Proliferation | 1 2 1 | Inflammation, Chronic | | Necrosis | 1 2 | Pigmentation | 1 | Bile Duct, Hyperplasia | | __________________________________________________________________________| Mesentery | + + + + + + +| Fat, Necrosis | 2 4 3 | Lymphatic, Angiectasis | | __________________________________________________________________________| Oral Mucosa | + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 4 | Basophilic Focus | X X X | Inflammation | 2 | Duct, Cyst | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + M + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 2 | Necrosis | 3 | Epithelium, Hyperplasia | 4 1 | __________________________________________________________________________| Stomach, Glandular | + + M + + + + + + + + + + + + + + A + + + + + + +| Mineralization | | Epithelium, Hyperplasia | 1 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 1 1 1 1 2 1 2 1 1 1 1 1 1 1 1 1 1 1| Inflammation, Suppurative | | Pigmentation, Hemosiderin | 2 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 19 NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 _____________________________________________________________________________________________________________________ | 7| 7| 6| 8| 8| 8| 5| 9| 6| 9| 6| 7| 9| 5| 9| 5| 6| 7| 8| 6| 6| 7| 7| 7| 8| DAY ON TEST | 4| 8| 9| 5| 7| 6| 8| 0| 6| 1| 9| 3| 1| 5| 1| 8| 5| 7| 4| 7| 6| 2| 6| 4| 3| | 1| 6| 6| 5| 4| 9| 8| 3| 0| 1| 7| 5| 1| 9| 2| 6| 1| 4| 7| 8| 5| 2| 7| 9| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 | Hypertrophy | 1 1 1 | Capsule, Hyperplasia | 3 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + M + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | M + + M + + + + M + M + M + + M M + + + + M + M M| __________________________________________________________________________| Pituitary Gland | + + + + + I + + + + + + + + + + + + + + + + + + +| Pars Distalis, Hyperplasia | 1 4 1 1 1 2 | Pars Intermedia, Hyperplasia | | Pars Intermedia, Hypertrophy | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Hyperplasia | 1 2 1 1 1 3 3 1 4 1 1 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | M M + + + + + + + + + + + + + + + + I + M + + M M| Inflammation, Chronic Active | 2 | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 | Atrophy | 2 3 2 3 3 2 2 3 2 3 2 3 2| Cyst | 2 2 4 1 1 2 2 2 2| Inflammation, Chronic | 2 | Interstitial Cell, Hyperplasia | 2 | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 | Cyst | 3 2 | Decidual Reaction | | Hydrometra | 3 | Inflammation, Chronic | 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 4 3 | __________________________________________________________________________| Lymph Node | + + + + | Lumbar, Hyperplasia | | Renal, Hyperplasia | 2 | __________________________________________________________________________| Lymph Node, Bronchial | M M + + M M + M + + + M M + + M M + + + M M M M +| Hyperplasia | 2 | __________________________________________________________________________| Lymph Node, Mandibular | M + + + + + + M + + + + M M + M + + + M + M + + +| Hyperplasia | 2 3 | _____________________________________________________________________________________________________________________| Page 20 NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 _____________________________________________________________________________________________________________________ | 7| 7| 6| 8| 8| 8| 5| 9| 6| 9| 6| 7| 9| 5| 9| 5| 6| 7| 8| 6| 6| 7| 7| 7| 8| DAY ON TEST | 4| 8| 9| 5| 7| 6| 8| 0| 6| 1| 9| 3| 1| 5| 1| 8| 5| 7| 4| 7| 6| 2| 6| 4| 3| | 1| 6| 6| 5| 4| 9| 8| 3| 0| 1| 7| 5| 1| 9| 2| 6| 1| 4| 7| 8| 5| 2| 7| 9| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Lymph Node, Mesenteric | + M + + + + + M + + + + + + M + + + + + + + A + +| Angiectasis | 3 | Hematopoietic Cell Proliferation | | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + M + M + + M + + + + + + M M + + M +| Hyperplasia | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 2 4 2 2 2 4 2 2 3 2 2 2 2 2 | Hyperplasia, Lymphoid | 2 | __________________________________________________________________________| Thymus | M M + M M + + M + + + + M + M M + + M + M + + + +| Atrophy | 2 | Hyperplasia, Lymphoid | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Vulva, Inflammation, Suppurative | 2 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Chondradysplasia | X | Fibrous Osteodystrophy | 2 1 1 2 2 1 | __________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hydrocephalus | | Meninges, Infiltration Cellular | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 1 1 3 1 2 1 2 1 1 1| Inflammation, Suppurative | 1 1 1 | Necrosis | | Epiglottis, Hyperplasia | | Epiglottis, Metaplasia, Squamous | 1 1 1 1 1 1 2 1 1 1 1 1 1| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion, Chronic | | Hemorrhage | | Alveolar Epithelium, Hyperplasia | 1 | Alveolar Epithelium, Metaplasia | 3 2 1 3 2 2 3 1 1 3 2 2 1 3 2 2 2 2 3 3 3 2 1 2 2| Alveolus, Infiltration Cellular, | | Histiocyte | 2 1 1 2 2 2 2 1 2 2 1 1 1 3 2 2 3 2 2 1 1 2 2| Mediastinum, Necrosis | 2 | _____________________________________________________________________________________________________________________| Page 21 NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 _____________________________________________________________________________________________________________________ | 7| 7| 6| 8| 8| 8| 5| 9| 6| 9| 6| 7| 9| 5| 9| 5| 6| 7| 8| 6| 6| 7| 7| 7| 8| DAY ON TEST | 4| 8| 9| 5| 7| 6| 8| 0| 6| 1| 9| 3| 1| 5| 1| 8| 5| 7| 4| 7| 6| 2| 6| 4| 3| | 1| 6| 6| 5| 4| 9| 8| 3| 0| 1| 7| 5| 1| 9| 2| 6| 1| 4| 7| 8| 5| 2| 7| 9| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Perivascular, Infiltration Cellular | 3 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Lateral Wall, Degeneration, Hyaline | 3 2 2 2 3 2 3 2 2 2 2 2 2 4 2 3 3 2 2 2 2 2 2 2 2| Lateral Wall, Fibrosis | 1 2 1 1 1 1 1 1 1 1 2 1 1 2 1 2 1 1 2 2 1 1 2 1| Lateral Wall, Hyperplasia | 2 2 2 2 3 2 2 2 2 2 2 2 2 2 1 3 2 2 2 2 2 2 2 2| Lateral Wall, Inflammation, | | Suppurative | 1 2 1 1 1 2 1 1 1 1 2 1 1 2 1 1 2 1 1 2 2 1 1 2 1| Lateral Wall, Metaplasia, Squamous | 1 1 2 1 1 1 1 2 3 1 1 2 3| Lateral Wall, Necrosis | 1 | Olfactory Epithelium, Atrophy | 3 3 1 3 2 1 2 1 4 3 1 2 2 2 2 2 2 2 2 2| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| Metaplasia, Squamous | 1 | Mineralization | | Necrosis | | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Glomerulosclerosis | 3 | Hydronephrosis | 2 | Karyomegaly | | Metaplasia, Osseous | 2 1 | Mineralization | | Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 2| Cortex, Inflammation, Suppurative | 2 | __________________________________________________________________________| Urinary Bladder | A + + + + + + + + + + + + + + + + A + + + + A + +| _____________________________________________________________________________________________________________________| Page 22 NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 __________________________________________________________________________________________________________________________________ | 9| 7| 7| 8| 9| 4| 9| 7| 8| 6| 8| 8| 4| 8| 9| 7| 6| 9| 9| 9| 8| 5| 6| 6| 9| | DAY ON TEST | 1| 7| 4| 5| 0| 5| 1| 0| 7| 8| 3| 8| 1| 4| 1| 5| 4| 1| 1| 1| 6| 3| 4| 9| 1| | | 1| 8| 9| 2| 3| 5| 2| 3| 4| 0| 3| 0| 6| 7| 2| 5| 7| 1| 2| 1| 9| 0| 6| 3| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + + + M + + + + + + A + + +| 44 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 | Necrosis | 2 | 1 2.0| Peyer's Patch, Hyperplasia | 4 | 1 4.0| __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 2 | 1 2.0| Basophilic Focus | X | 3 | Eosinophilic Focus | X X | 3 | Hematopoietic Cell Proliferation | 2 | 4 1.5| Inflammation, Chronic | 2 | 1 2.0| Necrosis | 2 | 3 1.7| Pigmentation | | 1 1.0| Bile Duct, Hyperplasia | 1 | 1 1.0| __________________________________________________________________________|____________| Mesentery | + + + | 10 | Fat, Necrosis | 2 | 4 2.8| Lymphatic, Angiectasis | 4 | 1 4.0| __________________________________________________________________________|____________| Oral Mucosa | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 | Atrophy | 2 3 | 3 3.0| Basophilic Focus | X X | 5 | Inflammation | | 1 2.0| Duct, Cyst | 3 2 | 2 2.5| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Suppurative | 2 1 | 3 1.7| Necrosis | | 1 3.0| Epithelium, Hyperplasia | 4 2 1 1 | 6 2.2| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Mineralization | 2 | 1 2.0| Epithelium, Hyperplasia | | 1 1.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 23 NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 __________________________________________________________________________________________________________________________________ | 9| 7| 7| 8| 9| 4| 9| 7| 8| 6| 8| 8| 4| 8| 9| 7| 6| 9| 9| 9| 8| 5| 6| 6| 9| | DAY ON TEST | 1| 7| 4| 5| 0| 5| 1| 0| 7| 8| 3| 8| 1| 4| 1| 5| 4| 1| 1| 1| 6| 3| 4| 9| 1| | | 1| 8| 9| 2| 3| 5| 2| 3| 4| 0| 3| 0| 6| 7| 2| 5| 7| 1| 2| 1| 9| 0| 6| 3| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | Cardiomyopathy | 1 1 1 1 1 2 2 1 1 1 1 1 1 3 1 2| 36 1.2| Inflammation, Suppurative | 2 | 1 2.0| Pigmentation, Hemosiderin | | 1 2.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 1 | 3 1.3| Hypertrophy | 1 1 1 | 6 1.0| Capsule, Hyperplasia | 2 | 2 2.5| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 2 1 1| 4 1.5| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + M + + + + + + + +| 48 | __________________________________________________________________________|____________| Parathyroid Gland | M M + M + + + M M M + M + + + + + M + I + + M M +| 29 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Pars Distalis, Hyperplasia | 2 2 1 4 2 1 2 3 2 1 | 16 1.9| Pars Intermedia, Hyperplasia | 2 | 1 2.0| Pars Intermedia, Hypertrophy | 2 | 1 2.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Follicular Cell, Hyperplasia | 2 1 1 2 1 4 3 4 1 2 2 1 1 1 3 3 2 2| 30 1.9| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + M + + + + + + + + + M + + + + + + +| 42 | Inflammation, Chronic Active | 2 | 2 2.0| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | | 1 2.0| Atrophy | 3 2 2 2 3 4 2 2 2 3 2 3 2 3 3 2 2| 30 2.5| Cyst | 3 2 3 2 3 2 3 | 16 2.3| Inflammation, Chronic | | 1 2.0| Interstitial Cell, Hyperplasia | 3 | 2 2.5| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 1 | 2 1.0| Cyst | 2 4 3 3 2 2 4| 9 2.8| Decidual Reaction | 2 | 1 2.0| Hydrometra | | 1 3.0| Inflammation, Chronic | | 1 2.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 24 NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 __________________________________________________________________________________________________________________________________ | 9| 7| 7| 8| 9| 4| 9| 7| 8| 6| 8| 8| 4| 8| 9| 7| 6| 9| 9| 9| 8| 5| 6| 6| 9| | DAY ON TEST | 1| 7| 4| 5| 0| 5| 1| 0| 7| 8| 3| 8| 1| 4| 1| 5| 4| 1| 1| 1| 6| 3| 4| 9| 1| | | 1| 8| 9| 2| 3| 5| 2| 3| 4| 0| 3| 0| 6| 7| 2| 5| 7| 1| 2| 1| 9| 0| 6| 3| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 3 | 4 3.0| __________________________________________________________________________|____________| Lymph Node | + + + + + | 9 | Lumbar, Hyperplasia | 2 | 1 2.0| Renal, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + + + + + + M + M + + + M + + + + + + + M +| 33 | Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + I + + + + + + + + + + + + + + + + + + M +| 41 | Hyperplasia | 2| 3 2.3| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + M M + + + + + + + + + + + + + + + + + + +| 44 | Angiectasis | | 1 3.0| Hematopoietic Cell Proliferation | 2| 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mediastinal | M + + + M M + + M + + + M + + M + + + + + + + + +| 38 | Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hematopoietic Cell Proliferation | 2 3 2 2 3 2 2| 21 2.3| Hyperplasia, Lymphoid | 2 2 2 | 4 2.0| __________________________________________________________________________|____________| Thymus | M + + + M + M + M M + M + + + M + + + + + + + + +| 33 | Atrophy | | 1 2.0| Hyperplasia, Lymphoid | 2 2 | 2 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 4 2 | 3 2.7| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Vulva, Inflammation, Suppurative | | 1 2.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Chondradysplasia | | 1 | Fibrous Osteodystrophy | 1 2 2 1 1 2 2 1| 14 1.5| __________________________________________________________________________|____________| Skeletal Muscle | + + | 2 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hydrocephalus | 1| 1 1.0| Meninges, Infiltration Cellular | 1 2 | 2 1.5| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 25 NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 __________________________________________________________________________________________________________________________________ | 9| 7| 7| 8| 9| 4| 9| 7| 8| 6| 8| 8| 4| 8| 9| 7| 6| 9| 9| 9| 8| 5| 6| 6| 9| | DAY ON TEST | 1| 7| 4| 5| 0| 5| 1| 0| 7| 8| 3| 8| 1| 4| 1| 5| 4| 1| 1| 1| 6| 3| 4| 9| 1| | | 1| 8| 9| 2| 3| 5| 2| 3| 4| 0| 3| 0| 6| 7| 2| 5| 7| 1| 2| 1| 9| 0| 6| 3| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 1 1 1 2 1 1 1 1 1 1 2 1 1| 24 1.3| Inflammation, Suppurative | 1 2 1 3 1 2 1 | 10 1.4| Necrosis | 1 1 | 2 1.0| Epiglottis, Hyperplasia | 1 1 1 1 | 4 1.0| Epiglottis, Metaplasia, Squamous | 1 1 1 1 1 1| 19 1.1| __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion, Chronic | 2 4 | 2 3.0| Hemorrhage | 2 | 1 2.0| Alveolar Epithelium, Hyperplasia | 4 4 | 3 3.0| Alveolar Epithelium, Metaplasia | 3 1 2 2 1 3 2 2 2 2 3 2 3 3 3 3 1 2 3 2 2 1 2 1 2| 50 2.1| Alveolus, Infiltration Cellular, | | | Histiocyte | 2 1 1 3 1 2 1 4 2 2 2 2 2 2 1 2 2 2 1 1 4 2| 45 1.8| Mediastinum, Necrosis | | 1 2.0| Perivascular, Infiltration Cellular | | 1 3.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lateral Wall, Degeneration, Hyaline | 2 3 2 2 2 4 2 2 2 2 3 3 4 2 2 3 3 3 3 2 2 4 2 2 2| 50 2.4| Lateral Wall, Fibrosis | 1 1 1 1 2 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 2 1 1 1| 48 1.2| Lateral Wall, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2| 47 2.0| Lateral Wall, Inflammation, | | | Suppurative | 1 1 1 1 1 2 1 1 1 1 1 1 2 1 1 2 1 1 2 1 1 2 1 1 1| 50 1.3| Lateral Wall, Metaplasia, Squamous | 1 1 1 2 1 1 1 1 1 1 1 1 2 3 1| 28 1.4| Lateral Wall, Necrosis | | 1 1.0| Olfactory Epithelium, Atrophy | 3 2 1 3 2 3 1 2 3 2 2 2 2 2 2 1 3 3 3 3| 40 2.2| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Metaplasia, Squamous | | 1 1.0| Mineralization | 2 | 1 2.0| Necrosis | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Harderian Gland | + + | 3 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Glomerulosclerosis | 3 | 2 3.0| Hydronephrosis | 2 | 2 2.0| Karyomegaly | 1 2 | 2 1.5| Metaplasia, Osseous | 1 1 1 | 5 1.2| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 26 NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 __________________________________________________________________________________________________________________________________ | 9| 7| 7| 8| 9| 4| 9| 7| 8| 6| 8| 8| 4| 8| 9| 7| 6| 9| 9| 9| 8| 5| 6| 6| 9| | DAY ON TEST | 1| 7| 4| 5| 0| 5| 1| 0| 7| 8| 3| 8| 1| 4| 1| 5| 4| 1| 1| 1| 6| 3| 4| 9| 1| | | 1| 8| 9| 2| 3| 5| 2| 3| 4| 0| 3| 0| 6| 7| 2| 5| 7| 1| 2| 1| 9| 0| 6| 3| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | Mineralization | 3 | 1 3.0| Nephropathy | 1 1 1 1 1 2 1 1 1 1 1 1 2| 30 1.1| Cortex, Inflammation, Suppurative | | 1 2.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + I + + + + + + + + + + + +| 46 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 27 NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 _____________________________________________________________________________________________________________________ | 9| 7| 8| 7| 7| 4| 8| 5| 8| 8| 3| 8| 7| 4| 9| 9| 9| 0| 9| 8| 9| 7| 6| 6| 8| DAY ON TEST | 1| 8| 8| 7| 0| 5| 0| 7| 0| 0| 9| 0| 6| 8| 1| 0| 1| 9| 1| 4| 1| 4| 9| 9| 4| | 2| 1| 3| 8| 1| 4| 7| 8| 7| 5| 1| 7| 7| 2| 1| 1| 2| 5| 2| 5| 1| 9| 3| 4| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + A + + + + + + +| __________________________________________________________________________| Gallbladder | + A + + + + + A + + A + + + + + + A M + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + A + + + + + A + + + + + + + + + A + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + A + + + + + A + + + + + + + + + A + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + A + + + + + A + + + + + + + + + A + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + A + + + + + A + + + + + + + + + A + + + + + + +| Necrosis | 2 | __________________________________________________________________________| Intestine Small, Jejunum | + A + + + + + A + + + + + + + + + A + + + + + A +| __________________________________________________________________________| Intestine Small, Ileum | + A + + + + + M + + + + + + + + + A + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + A + + + + + + +| Basophilic Focus | X X | Clear Cell Focus | | Degeneration, Fatty | 2 | Eosinophilic Focus | X X X X | Hematopoietic Cell Proliferation | 3 | Hepatodiaphragmatic Nodule | | Inflammation, Chronic | 1 3 | Necrosis | 1 1 3 | Bile Duct, Cyst | 4 | __________________________________________________________________________| Mesentery | + + | Fat, Necrosis | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + M + + + + + + +| Atrophy | 2 3 | Basophilic Focus | X | Vacuolization Cytoplasmic | 2 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + A + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + A + + + + + + +| Epithelium, Hyperplasia | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + A + + + + + + +| Inflammation, Acute | 2 | Necrosis | 1 | Epithelium, Hyperplasia | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 2 1 1 1 1 2 1 2 1 1 2 2 1 1 1 1 1 1 3| Inflammation, Suppurative | 2 | Necrosis | | Atrium, Thrombosis | 4| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + A + + + + + + + + + A I + + + + + +| Hyperplasia | 1 1 2 | Hypertrophy | 1 1 2 1 1 1 3 1 1 | _____________________________________________________________________________________________________________________| Page 28 NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 _____________________________________________________________________________________________________________________ | 9| 7| 8| 7| 7| 4| 8| 5| 8| 8| 3| 8| 7| 4| 9| 9| 9| 0| 9| 8| 9| 7| 6| 6| 8| DAY ON TEST | 1| 8| 8| 7| 0| 5| 0| 7| 0| 0| 9| 0| 6| 8| 1| 0| 1| 9| 1| 4| 1| 4| 9| 9| 4| | 2| 1| 3| 8| 1| 4| 7| 8| 7| 5| 1| 7| 7| 2| 1| 1| 2| 5| 2| 5| 1| 9| 3| 4| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Capsule, Hyperplasia | 2 2 2 2 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + A + + + + + + + + + A + + + + + + +| Hyperplasia | 2 4| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + M + + + + + + +| Hyperplasia | | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + M + + A + M + + + + +| __________________________________________________________________________| Pituitary Gland | + M + + + + + + + + + + + + + + + A + I + + + + +| Pars Distalis, Hyperplasia | | Pars Intermedia, Hyperplasia | 1 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + A + + + + + + +| Follicular Cell, Hyperplasia | 1 1 1 1 1 1 1 1| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + A + + + + + + +| Granuloma Sperm | | Inflammation | | __________________________________________________________________________| Penis | + + | Inflammation, Suppurative | 2 3 | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + A + + + + + + +| Cyst | 2 3 4 3| Inflammation, Chronic Active | 3 4 4 4 3 4| __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + A + + + + + M +| Hyperplasia | 1 | Inflammation, Suppurative | 3 2 | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + A + + + + + + +| Inflammation, Suppurative | 2 | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 1 1 3 3 1 3 1| Interstitial Cell, Hyperplasia | 2 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + A + + + + + + +| Hyperplasia | 2 2 | Necrosis | 4 | __________________________________________________________________________| Lymph Node | + + | Iliac, Infiltration Cellular, Plasma | | Cell | 4 | __________________________________________________________________________| Lymph Node, Bronchial | + M + M M + + + M M + + + + M M + A + M M M M + +| __________________________________________________________________________| Lymph Node, Mandibular | M M M M + + + + + I + + + M + + + M + + + + M + M| Hyperplasia | 2 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + A + + + + + + +| _____________________________________________________________________________________________________________________| Page 29 NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 _____________________________________________________________________________________________________________________ | 9| 7| 8| 7| 7| 4| 8| 5| 8| 8| 3| 8| 7| 4| 9| 9| 9| 0| 9| 8| 9| 7| 6| 6| 8| DAY ON TEST | 1| 8| 8| 7| 0| 5| 0| 7| 0| 0| 9| 0| 6| 8| 1| 0| 1| 9| 1| 4| 1| 4| 9| 9| 4| | 2| 1| 3| 8| 1| 4| 7| 8| 7| 5| 1| 7| 7| 2| 1| 1| 2| 5| 2| 5| 1| 9| 3| 4| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Angiectasis | 2 1 3| Congestion | 4 | Hematopoietic Cell Proliferation | 2 | Hyperplasia | | __________________________________________________________________________| Lymph Node, Mediastinal | + + M + + + + + + + M M + + + + + A + + + M + + +| Hyperplasia | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + M + + + + + + +| Angiectasis | 2 | Hematopoietic Cell Proliferation | 2 3 3 2 2 2 2 2 2| Hyperplasia, Lymphoid | 2 | Pigmentation, Melanin | 2 | __________________________________________________________________________| Thymus | + + M + + M M + M + + M + + M M + A + M + + + M M| Atrophy | 3 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + A + + + + + + +| Inflammation, Chronic Active | | Prepuce, Inflammation, Chronic Active| 4 4 4 4 | Subcutaneous Tissue, Hemorrhage | 3 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | | __________________________________________________________________________| Skeletal Muscle | + + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + A + + + + + + +| Developmental Malformation | X | Hemorrhage | 1 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + A + + + + + + +| Hyperplasia | 1 1 1 1 | Inflammation, Acute | 1 | Inflammation, Chronic | | Inflammation, Chronic Active | 1 | Inflammation, Suppurative | 2| Epiglottis, Hyperplasia | | Epiglottis, Metaplasia, Squamous | 1 | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + A + + + + + + +| Angiectasis | 1 | Hemorrhage | 1 | Alveolar Epithelium, Hyperplasia | 4 4 1 | _____________________________________________________________________________________________________________________| Page 30 NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 _____________________________________________________________________________________________________________________ | 9| 7| 8| 7| 7| 4| 8| 5| 8| 8| 3| 8| 7| 4| 9| 9| 9| 0| 9| 8| 9| 7| 6| 6| 8| DAY ON TEST | 1| 8| 8| 7| 0| 5| 0| 7| 0| 0| 9| 0| 6| 8| 1| 0| 1| 9| 1| 4| 1| 4| 9| 9| 4| | 2| 1| 3| 8| 1| 4| 7| 8| 7| 5| 1| 7| 7| 2| 1| 1| 2| 5| 2| 5| 1| 9| 3| 4| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Alveolus, Infiltration Cellular, | | Histiocyte | | Perivascular, Infiltration Cellular | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + A + + + + + + +| Lateral Wall, Degeneration, Hyaline | | Lateral Wall, Hyperplasia | | Lateral Wall, Inflammation, | | Suppurative | | Lateral Wall, Metaplasia, Squamous | | Nasolacrimal Duct, Inflammation, | | Suppurative | 2 2 | Olfactory Epithelium, Atrophy | 2 1 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + A + + + + + + +| Hyperplasia | | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | Inflammation | 4 | __________________________________________________________________________| Harderian Gland | + + + + + | __________________________________________________________________________| Lacrimal Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + A + + + + + + +| Cyst | 2 | Infarct | 4 | Nephropathy | 2 2 1 1 1 1 1 1 2 1 1 1 1 1 1 2 3| Papilla, Inflammation, Suppurative | 2 2 3 | Papilla, Necrosis | | Pelvis, Dilatation | 3 3 | Renal Tubule, Hyperplasia | | __________________________________________________________________________| Urinary Bladder | + + + + + + + A + + + + M + + + + A + + + + + + +| Inflammation, Chronic Active | 4 4 | Inflammation, Suppurative | | _____________________________________________________________________________________________________________________| Page 31 NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 __________________________________________________________________________________________________________________________________ | 5| 3| 9| 3| 9| 8| 9| 8| 8| 9| 9| 6| 7| 8| 7| 9| 7| 7| 9| 9| 6| 8| 3| 9| 9| | DAY ON TEST | 2| 8| 1| 2| 1| 8| 1| 4| 1| 1| 1| 0| 2| 1| 9| 1| 0| 2| 1| 1| 6| 6| 9| 1| 0| | | 7| 7| 2| 8| 1| 2| 1| 0| 7| 1| 2| 5| 1| 0| 1| 1| 7| 2| 2| 1| 5| 9| 2| 1| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + M A + + + + + + + + + + + + + + + +| 43 | __________________________________________________________________________|____________| Intestine Large, Colon | + A + A + + + + + + + + + + + + + + + + + + + + +| 45 | __________________________________________________________________________|____________| Intestine Large, Rectum | + A + + + + + + + + + + + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Intestine Large, Cecum | + A + A + + + + A + + + + + + + + + + + + + + + +| 44 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + A + A + + + + A + + + + + + + + + + + + + + + +| 44 | Necrosis | | 1 2.0| __________________________________________________________________________|____________| Intestine Small, Jejunum | + A + A + + + + A + + + + + + + + + + + + + + + +| 43 | __________________________________________________________________________|____________| Intestine Small, Ileum | + A + A + + + + A + + + + + + + + + + + + + + + +| 44 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Basophilic Focus | | 2 | Clear Cell Focus | X | 1 | Degeneration, Fatty | 2 | 2 2.0| Eosinophilic Focus | X X X X X X | 10 | Hematopoietic Cell Proliferation | 2 | 2 2.5| Hepatodiaphragmatic Nodule | X | 1 | Inflammation, Chronic | | 2 2.0| Necrosis | | 3 1.7| Bile Duct, Cyst | | 1 4.0| __________________________________________________________________________|____________| Mesentery | + | 3 | Fat, Necrosis | 2 | 1 2.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Atrophy | 2 | 3 2.3| Basophilic Focus | | 1 | Vacuolization Cytoplasmic | | 1 2.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Epithelium, Hyperplasia | 3 | 1 3.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Acute | | 1 2.0| Necrosis | 1 | 2 1.0| Epithelium, Hyperplasia | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 1 1 1 1 1 1 2 1 1 2 2 1 1 1 1 2 1 1 2 1| 40 1.3| Inflammation, Suppurative | 1 | 2 1.5| Necrosis | 3 | 1 3.0| Atrium, Thrombosis | 4 | 2 4.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 32 NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 __________________________________________________________________________________________________________________________________ | 5| 3| 9| 3| 9| 8| 9| 8| 8| 9| 9| 6| 7| 8| 7| 9| 7| 7| 9| 9| 6| 8| 3| 9| 9| | DAY ON TEST | 2| 8| 1| 2| 1| 8| 1| 4| 1| 1| 1| 0| 2| 1| 9| 1| 0| 2| 1| 1| 6| 6| 9| 1| 0| | | 7| 7| 2| 8| 1| 2| 1| 0| 7| 1| 2| 5| 1| 0| 1| 1| 7| 2| 2| 1| 5| 9| 2| 1| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Hyperplasia | 2 2 2 2 1 2 | 9 1.7| Hypertrophy | 1 1 1 2 1 1 1 1 1 3 1 | 20 1.3| Capsule, Hyperplasia | 2 2 2 2 3 | 9 2.1| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Hyperplasia | | 2 3.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | 4 1 2 3 | 4 2.5| __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + M + M + + + + + + + M + + + + M +| 43 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Pars Distalis, Hyperplasia | 1 | 1 1.0| Pars Intermedia, Hyperplasia | | 1 1.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Follicular Cell, Hyperplasia | 2 3 1 4 1 1 2 1 1 1 | 18 1.4| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Granuloma Sperm | 3 | 1 3.0| Inflammation | 2 2 | 2 2.0| __________________________________________________________________________|____________| Penis | + + | 4 | Inflammation, Suppurative | 2 | 3 2.3| __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Cyst | 3 4 2 3 2 4 3 | 11 3.0| Inflammation, Chronic Active | 3 2 3 1 3 3 2 3 2| 15 2.9| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Hyperplasia | | 1 1.0| Inflammation, Suppurative | 1 | 3 2.0| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + M + + + + + + + + + +| 48 | Inflammation, Suppurative | | 1 2.0| __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 4 3 4 2| 11 2.4| Interstitial Cell, Hyperplasia | | 2 2.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 33 NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 __________________________________________________________________________________________________________________________________ | 5| 3| 9| 3| 9| 8| 9| 8| 8| 9| 9| 6| 7| 8| 7| 9| 7| 7| 9| 9| 6| 8| 3| 9| 9| | DAY ON TEST | 2| 8| 1| 2| 1| 8| 1| 4| 1| 1| 1| 0| 2| 1| 9| 1| 0| 2| 1| 1| 6| 6| 9| 1| 0| | | 7| 7| 2| 8| 1| 2| 1| 0| 7| 1| 2| 5| 1| 0| 1| 1| 7| 2| 2| 1| 5| 9| 2| 1| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | 3 | 3 2.3| Necrosis | | 1 4.0| __________________________________________________________________________|____________| Lymph Node | | 2 | Iliac, Infiltration Cellular, Plasma | | | Cell | | 1 4.0| __________________________________________________________________________|____________| Lymph Node, Bronchial | + + M + + M M + + + + M M + M M + + M M M + + M M| 26 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + M + M M + M + + + + + + + M + M + M + +| 34 | Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + M + + + + + + + + + + + + + + + + + + + + +| 48 | Angiectasis | | 3 2.0| Congestion | | 1 4.0| Hematopoietic Cell Proliferation | 4 | 2 3.0| Hyperplasia | 2 2 | 2 2.0| __________________________________________________________________________|____________| Lymph Node, Mediastinal | + M + M M + + + + + M + M + + + + + + + M + M + M| 37 | Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Angiectasis | | 1 2.0| Hematopoietic Cell Proliferation | 2 2 2 2 2 | 14 2.1| Hyperplasia, Lymphoid | 4 | 2 3.0| Pigmentation, Melanin | | 1 2.0| __________________________________________________________________________|____________| Thymus | + + + + + M M M + M + M + + + I + M M + + M + + M| 29 | Atrophy | 3 2 3 | 4 2.8| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Chronic Active | 2| 1 2.0| Prepuce, Inflammation, Chronic Active| 3 4 4 3 2 4 4 | 11 3.6| Subcutaneous Tissue, Hemorrhage | | 1 3.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrous Osteodystrophy | 1 | 1 1.0| __________________________________________________________________________|____________| Skeletal Muscle | | 2 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Developmental Malformation | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 34 NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 __________________________________________________________________________________________________________________________________ | 5| 3| 9| 3| 9| 8| 9| 8| 8| 9| 9| 6| 7| 8| 7| 9| 7| 7| 9| 9| 6| 8| 3| 9| 9| | DAY ON TEST | 2| 8| 1| 2| 1| 8| 1| 4| 1| 1| 1| 0| 2| 1| 9| 1| 0| 2| 1| 1| 6| 6| 9| 1| 0| | | 7| 7| 2| 8| 1| 2| 1| 0| 7| 1| 2| 5| 1| 0| 1| 1| 7| 2| 2| 1| 5| 9| 2| 1| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM - cont | | | | | | Hemorrhage | | 1 1.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | | 4 1.0| Inflammation, Acute | | 1 1.0| Inflammation, Chronic | 1 | 1 1.0| Inflammation, Chronic Active | 1 1 1 1 1| 6 1.0| Inflammation, Suppurative | | 1 2.0| Epiglottis, Hyperplasia | 1 | 1 1.0| Epiglottis, Metaplasia, Squamous | 1 | 2 1.0| __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Angiectasis | | 1 1.0| Hemorrhage | | 1 1.0| Alveolar Epithelium, Hyperplasia | 3 3 3 1 4 3 2| 10 2.8| Alveolus, Infiltration Cellular, | | | Histiocyte | 2 4 3 | 3 3.0| Perivascular, Infiltration Cellular | 2 | 1 2.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Lateral Wall, Degeneration, Hyaline | 1 2 | 2 1.5| Lateral Wall, Hyperplasia | 1 1 | 2 1.0| Lateral Wall, Inflammation, | | | Suppurative | 1 | 1 1.0| Lateral Wall, Metaplasia, Squamous | 1 | 1 1.0| Nasolacrimal Duct, Inflammation, | | | Suppurative | | 2 2.0| Olfactory Epithelium, Atrophy | 2 2 | 4 1.8| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | 4 | 1 4.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + + | 3 | Inflammation | 3 | 2 3.5| __________________________________________________________________________|____________| Harderian Gland | + + | 7 | __________________________________________________________________________|____________| Lacrimal Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Cyst | 2 2 2 | 4 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 35 NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 __________________________________________________________________________________________________________________________________ | 5| 3| 9| 3| 9| 8| 9| 8| 8| 9| 9| 6| 7| 8| 7| 9| 7| 7| 9| 9| 6| 8| 3| 9| 9| | DAY ON TEST | 2| 8| 1| 2| 1| 8| 1| 4| 1| 1| 1| 0| 2| 1| 9| 1| 0| 2| 1| 1| 6| 6| 9| 1| 0| | | 7| 7| 2| 8| 1| 2| 1| 0| 7| 1| 2| 5| 1| 0| 1| 1| 7| 2| 2| 1| 5| 9| 2| 1| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | Infarct | | 1 4.0| Nephropathy | 1 2 1 1 2 1 2 1 1 1 3 1 2 1 1 1 1 2 1 1 2 1 2| 40 1.4| Papilla, Inflammation, Suppurative | | 3 2.3| Papilla, Necrosis | 2 | 1 2.0| Pelvis, Dilatation | | 2 3.0| Renal Tubule, Hyperplasia | 1 | 1 1.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Inflammation, Chronic Active | | 2 4.0| Inflammation, Suppurative | 2 | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 36 NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 _____________________________________________________________________________________________________________________ | 9| 7| 8| 6| 9| 6| 6| 6| 4| 9| 8| 9| 9| 8| 5| 7| 7| 6| 7| 7| 9| 7| 9| 6| 9| DAY ON TEST | 1| 9| 6| 9| 1| 1| 9| 5| 7| 1| 2| 1| 1| 0| 6| 9| 0| 3| 7| 2| 1| 2| 0| 7| 1| | 2| 8| 9| 3| 1| 0| 3| 1| 1| 1| 3| 1| 2| 4| 8| 9| 9| 2| 3| 1| 2| 2| 1| 8| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + A + + + + M + + + + + + + + A + + + A +| Inflammation, Suppurative | | Epithelium, Hyperplasia | 1 | __________________________________________________________________________| Intestine Large, Colon | + + + + + A + + + + + + + + + + + + + A + + + A +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + A +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + A + + + + + + + + + + + + + A + + + A +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + A + + + + + + + + + + + + + A + + + A +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + A + + + + + + + + + + + A + A + + + A +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + A + + + + + + + + + + + + + A + + + A +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | | Degeneration, Fatty | 3 | Eosinophilic Focus | X X X X X | Hematopoietic Cell Proliferation | 2 | Inflammation, Chronic | | Necrosis | 3 1 2 1| Bile Duct, Cyst | | Centrilobular, Necrosis | 2 | __________________________________________________________________________| Mesentery | + + +| Fat, Necrosis | 3 | __________________________________________________________________________| Oral Mucosa | + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + A +| Atrophy | 1 4 | Duct, Cyst | 3 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + A +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + A +| Inflammation, Suppurative | 1 | Epithelium, Hyperplasia | 1 1 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + A + + + A +| Inflammation, Acute | 3 | Mineralization | 2 | Necrosis | 2 3 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 1 1 1 1 1 1 1 2 1 1 1 2 1 1 1 2| Mineralization | 1 | Atrium, Thrombosis | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + A +| Hyperplasia | 2 1 2 2 2 2 2 1| Hypertrophy | 1 2 1 1 1 1 1 2 1 1 | _____________________________________________________________________________________________________________________| Page 37 NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 _____________________________________________________________________________________________________________________ | 9| 7| 8| 6| 9| 6| 6| 6| 4| 9| 8| 9| 9| 8| 5| 7| 7| 6| 7| 7| 9| 7| 9| 6| 9| DAY ON TEST | 1| 9| 6| 9| 1| 1| 9| 5| 7| 1| 2| 1| 1| 0| 6| 9| 0| 3| 7| 2| 1| 2| 0| 7| 1| | 2| 8| 9| 3| 1| 0| 3| 1| 1| 1| 3| 1| 2| 4| 8| 9| 9| 2| 3| 1| 2| 2| 1| 8| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Capsule, Hyperplasia | 2 2 2 2 3 2 2 2| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + M + + + + + + + + A +| Hyperplasia | 2 | Thrombosis | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + A +| Hyperplasia | | __________________________________________________________________________| Parathyroid Gland | M M M M M + + + M + + + M + + + + + + M + + M M +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + M + + + + +| Pars Distalis, Hyperplasia | 1 2 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + I + + + + + + + + + + + + + + + + A +| Follicular Cell, Hyperplasia | 1 1 1 3 1 1 2 4 1| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + A +| Atrophy | | Granuloma Sperm | 4 | Inflammation, Chronic | 4 | __________________________________________________________________________| Penis | + + | Inflammation, Suppurative | 3 2 | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + A +| Cyst | 2 3 3 3 3 2| Inflammation, Chronic Active | 4 1 4 1 3 3 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + M + + + + + + + + + A +| Inflammation, Suppurative | 1 2 3 1 | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + A +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + A +| Atrophy | 3 1 4 1 | Mineralization | | Interstitial Cell, Hyperplasia | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + A +| Hyperplasia | 3 3 | __________________________________________________________________________| Lymph Node | +| Iliac, Pigmentation | | __________________________________________________________________________| Lymph Node, Bronchial | M + + + M M M M + + M + M + + M + + + + M M M M +| Hyperplasia | | __________________________________________________________________________| Lymph Node, Mandibular | M + + M + + M I + M + M + + M + M + M + + + + M +| Hyperplasia | 2 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + M + + + + + + + + + M + + + + + M +| Congestion | | _____________________________________________________________________________________________________________________| Page 38 NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 _____________________________________________________________________________________________________________________ | 9| 7| 8| 6| 9| 6| 6| 6| 4| 9| 8| 9| 9| 8| 5| 7| 7| 6| 7| 7| 9| 7| 9| 6| 9| DAY ON TEST | 1| 9| 6| 9| 1| 1| 9| 5| 7| 1| 2| 1| 1| 0| 6| 9| 0| 3| 7| 2| 1| 2| 0| 7| 1| | 2| 8| 9| 3| 1| 0| 3| 1| 1| 1| 3| 1| 2| 4| 8| 9| 9| 2| 3| 1| 2| 2| 1| 8| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Hemorrhage | | Hyperplasia | | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + M + + M + + I + + M + M + + M + + + + A +| Hyperplasia | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + A +| Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 | Hyperplasia, Lymphoid | | __________________________________________________________________________| Thymus | + M M + M + + + + + + + M M M + + M M + + M M A +| Atrophy | 3 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 4 | Epidermis, Hyperplasia | 1 2 | Prepuce, Inflammation, Chronic Active| 4 4 4 4 3 4 4 | Subcutaneous Tissue, Edema | 3 | Subcutaneous Tissue, Infiltration | | Cellular, Mast Cell | 2 | Subcutaneous Tissue, Inflammation, | | Chronic | 2| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + A +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + A +| Hyperplasia | 1 2 | Inflammation, Chronic Active | 1 1 1 1 | Inflammation, Suppurative | 1 1 | Epiglottis, Hyperplasia | 1 | Epiglottis, Metaplasia, Squamous | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + A +| Inflammation, Chronic, Focal | | Alveolar Epithelium, Hyperplasia | 2 4 3 4 1| Alveolar Epithelium, Metaplasia | 1 1 2 1 1 2 2 2 2 2 1 2 1 3 1 2 2 1 1 1 1 2 2| Alveolus, Infiltration Cellular, | | Histiocyte | 1 1 4 2 1 1 1 1 2 1 1 2 1 1 1 1 1 1 1| __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + A +| Lateral Wall, Degeneration, Hyaline | 1 1 1 1 1 2 2 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 2| _____________________________________________________________________________________________________________________| Page 39 NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 _____________________________________________________________________________________________________________________ | 9| 7| 8| 6| 9| 6| 6| 6| 4| 9| 8| 9| 9| 8| 5| 7| 7| 6| 7| 7| 9| 7| 9| 6| 9| DAY ON TEST | 1| 9| 6| 9| 1| 1| 9| 5| 7| 1| 2| 1| 1| 0| 6| 9| 0| 3| 7| 2| 1| 2| 0| 7| 1| | 2| 8| 9| 3| 1| 0| 3| 1| 1| 1| 3| 1| 2| 4| 8| 9| 9| 2| 3| 1| 2| 2| 1| 8| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Lateral Wall, Fibrosis | 1 1 1 1 1 1 | Lateral Wall, Hyperplasia | 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1| Lateral Wall, Inflammation, | | Suppurative | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Lateral Wall, Metaplasia, Squamous | 1 | Nasolacrimal Duct, Inflammation, | | Suppurative | | Olfactory Epithelium, Atrophy | 1 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + A +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | Inflammation | | __________________________________________________________________________| Harderian Gland | + + + | __________________________________________________________________________| Zymbal's Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + A +| Cyst | 2 | Hydronephrosis | 2 | Mineralization | 2 2 | Nephropathy | 2 2 1 1 2 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1| Cortex, Inflammation, Suppurative | 2 3 | Papilla, Inflammation, Suppurative | 2 2 3 1 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + A +| Calculus Gross Observation | X X X | Inflammation, Chronic Active | | Inflammation, Suppurative | 4 3 4 4 | _____________________________________________________________________________________________________________________| Page 40 NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 __________________________________________________________________________________________________________________________________ | 7| 3| 6| 7| 6| 8| 7| 9| 8| 8| 9| 4| 7| 8| 8| 7| 8| 8| 8| 9| 9| 8| 7| 7| 6| | DAY ON TEST | 1| 8| 7| 9| 4| 4| 3| 1| 4| 4| 1| 4| 0| 2| 1| 3| 0| 8| 7| 1| 1| 3| 8| 2| 1| | | 6| 6| 8| 1| 9| 7| 5| 1| 5| 7| 2| 6| 7| 6| 2| 5| 5| 0| 5| 1| 2| 8| 7| 1| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | + + A + + + + + + + + + + + + + + + + + + A + + +| 44 | Inflammation, Suppurative | 1 | 1 1.0| Epithelium, Hyperplasia | | 1 1.0| __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + A + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + A + + + + + + + + + + + + + + + + + + A + + +| 45 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + A + + + + + + + + + + + + + + + + + + A + + +| 45 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + A + + + + + + + + + + + + + + + + + + A + + +| 44 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + A + + + + + + + + + + + + + + + + + + A + + +| 45 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X | 1 | Degeneration, Fatty | | 1 3.0| Eosinophilic Focus | X X X X | 9 | Hematopoietic Cell Proliferation | | 1 2.0| Inflammation, Chronic | 3 | 1 3.0| Necrosis | 2 1 1 1 | 8 1.5| Bile Duct, Cyst | 3 | 1 3.0| Centrilobular, Necrosis | | 1 2.0| __________________________________________________________________________|____________| Mesentery | | 3 | Fat, Necrosis | | 1 3.0| __________________________________________________________________________|____________| Oral Mucosa | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Atrophy | 4 | 3 3.0| Duct, Cyst | | 1 3.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Suppurative | 3 | 2 2.0| Epithelium, Hyperplasia | 3 4 | 4 2.3| __________________________________________________________________________|____________| Stomach, Glandular | + + A + + + + + + + + + + + + + + + + + + + + + +| 47 | Inflammation, Acute | | 1 3.0| Mineralization | | 1 2.0| Necrosis | 1 | 3 2.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 2 1 1| 40 1.2| Mineralization | | 1 1.0| Atrium, Thrombosis | 3 | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 41 NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 __________________________________________________________________________________________________________________________________ | 7| 3| 6| 7| 6| 8| 7| 9| 8| 8| 9| 4| 7| 8| 8| 7| 8| 8| 8| 9| 9| 8| 7| 7| 6| | DAY ON TEST | 1| 8| 7| 9| 4| 4| 3| 1| 4| 4| 1| 4| 0| 2| 1| 3| 0| 8| 7| 1| 1| 3| 8| 2| 1| | | 6| 6| 8| 1| 9| 7| 5| 1| 5| 7| 2| 6| 7| 6| 2| 5| 5| 0| 5| 1| 2| 8| 7| 1| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | 2 2 2 2 1| 13 1.8| Hypertrophy | 2 1 1 1 2 2 | 16 1.3| Capsule, Hyperplasia | 2 2 2 2 | 12 2.1| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Hyperplasia | 1 | 2 1.5| Thrombosis | 4 | 1 4.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Parathyroid Gland | + + M + + M + M M + + + + + + + + + M M + M + M +| 32 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Pars Distalis, Hyperplasia | 2 | 4 1.8| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Follicular Cell, Hyperplasia | 1 1 1 1 1 1 3 1 1 1 1 | 20 1.4| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Atrophy | 4 | 1 4.0| Granuloma Sperm | | 1 4.0| Inflammation, Chronic | | 1 4.0| __________________________________________________________________________|____________| Penis | | 2 | Inflammation, Suppurative | | 2 2.5| __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Cyst | 3 4 3 3 3 | 11 2.9| Inflammation, Chronic Active | 1 3 4 2 2 4 1 | 13 2.5| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + M + + + + + + +| 47 | Inflammation, Suppurative | 2 | 5 1.8| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Atrophy | 3 2 2 2 1 2 | 10 2.1| Mineralization | 2 | 1 2.0| Interstitial Cell, Hyperplasia | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 42 NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 __________________________________________________________________________________________________________________________________ | 7| 3| 6| 7| 6| 8| 7| 9| 8| 8| 9| 4| 7| 8| 8| 7| 8| 8| 8| 9| 9| 8| 7| 7| 6| | DAY ON TEST | 1| 8| 7| 9| 4| 4| 3| 1| 4| 4| 1| 4| 0| 2| 1| 3| 0| 8| 7| 1| 1| 3| 8| 2| 1| | | 6| 6| 8| 1| 9| 7| 5| 1| 5| 7| 2| 6| 7| 6| 2| 5| 5| 0| 5| 1| 2| 8| 7| 1| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | 3 2 2 | 5 2.6| __________________________________________________________________________|____________| Lymph Node | + + | 3 | Iliac, Pigmentation | 2 | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Bronchial | M + + + M + M M M + M + M + M + + M + + + M + M +| 27 | Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | M + + M + + + + + M + + + M + M M M + M M + + + +| 31 | Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + M + + + + + + + + + + + + + + + +| 46 | Congestion | 3 2 | 2 2.5| Hemorrhage | 2 | 1 2.0| Hyperplasia | 2 2 | 2 2.0| __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + M + + + + + + + + M M + + + + M + + + +| 39 | Hyperplasia | 3 2 3 2 2 | 5 2.4| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 | 14 2.0| Hyperplasia, Lymphoid | 2 3 | 2 2.5| __________________________________________________________________________|____________| Thymus | M + + + M M M M + M M + M + M + M M + + + + M M +| 26 | Atrophy | | 1 3.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | | 1 4.0| Epidermis, Hyperplasia | | 2 1.5| Prepuce, Inflammation, Chronic Active| 4 4 4 4 4 4| 13 3.9| Subcutaneous Tissue, Edema | | 1 3.0| Subcutaneous Tissue, Infiltration | | | Cellular, Mast Cell | | 1 2.0| Subcutaneous Tissue, Inflammation, | | | Chronic | | 1 2.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrous Osteodystrophy | 2 2 | 2 2.0| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 43 NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 __________________________________________________________________________________________________________________________________ | 7| 3| 6| 7| 6| 8| 7| 9| 8| 8| 9| 4| 7| 8| 8| 7| 8| 8| 8| 9| 9| 8| 7| 7| 6| | DAY ON TEST | 1| 8| 7| 9| 4| 4| 3| 1| 4| 4| 1| 4| 0| 2| 1| 3| 0| 8| 7| 1| 1| 3| 8| 2| 1| | | 6| 6| 8| 1| 9| 7| 5| 1| 5| 7| 2| 6| 7| 6| 2| 5| 5| 0| 5| 1| 2| 8| 7| 1| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | 2 1 1 1 1 | 7 1.3| Inflammation, Chronic Active | 1 2 1 | 7 1.1| Inflammation, Suppurative | 1 2 2 | 5 1.4| Epiglottis, Hyperplasia | 1 | 2 1.0| Epiglottis, Metaplasia, Squamous | 1 | 1 1.0| __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Chronic, Focal | 2 | 1 2.0| Alveolar Epithelium, Hyperplasia | 4 4 4 | 8 3.3| Alveolar Epithelium, Metaplasia | 1 1 1 2 1 2 1 1 2 2 1 1 1 1 2 3 1 1 1 2 2 1 1 1 2| 48 1.5| Alveolus, Infiltration Cellular, | | | Histiocyte | 3 1 1 3 4 4 3 1 1 1 3 1 4 3 2 3 1 1 1 4 1 | 40 1.8| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + A + + +| 48 | Lateral Wall, Degeneration, Hyaline | 1 1 1 1 1 1 1 1 1 1 2 2 1 1 1 1 1 1 1 1 1 1 1 1| 48 1.1| Lateral Wall, Fibrosis | 1 1| 8 1.0| Lateral Wall, Hyperplasia | 1 1 1 2 1 2 1 1 1 1 1 1 1 1 | 33 1.1| Lateral Wall, Inflammation, | | | Suppurative | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 38 1.0| Lateral Wall, Metaplasia, Squamous | 2 | 2 1.5| Nasolacrimal Duct, Inflammation, | | | Suppurative | 2 2 | 2 2.0| Olfactory Epithelium, Atrophy | 3 3 2 | 4 2.3| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | +| 1 | Inflammation | 4| 1 4.0| __________________________________________________________________________|____________| Harderian Gland | + + + + +| 8 | __________________________________________________________________________|____________| Zymbal's Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Cyst | | 1 2.0| Hydronephrosis | | 1 2.0| Mineralization | | 2 2.0| Nephropathy | 1 1 2 3 1 1 1 1 1 1 1 2 1 1 1 2 1 1 2 1 1 1 1| 43 1.2| Cortex, Inflammation, Suppurative | | 2 2.5| Papilla, Inflammation, Suppurative | 2 2 | 6 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 44 NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 __________________________________________________________________________________________________________________________________ | 7| 3| 6| 7| 6| 8| 7| 9| 8| 8| 9| 4| 7| 8| 8| 7| 8| 8| 8| 9| 9| 8| 7| 7| 6| | DAY ON TEST | 1| 8| 7| 9| 4| 4| 3| 1| 4| 4| 1| 4| 0| 2| 1| 3| 0| 8| 7| 1| 1| 3| 8| 2| 1| | | 6| 6| 8| 1| 9| 7| 5| 1| 5| 7| 2| 6| 7| 6| 2| 5| 5| 0| 5| 1| 2| 8| 7| 1| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Calculus Gross Observation | | 3 | Inflammation, Chronic Active | 4 | 1 4.0| Inflammation, Suppurative | 4 | 5 3.8| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 45 NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 _____________________________________________________________________________________________________________________ | 9| 9| 6| 7| 9| 8| 6| 4| 7| 6| 8| 9| 8| 6| 7| 9| 7| 9| 8| 5| 6| 8| 5| 5| 7| DAY ON TEST | 1| 1| 7| 4| 1| 1| 6| 6| 3| 2| 3| 1| 0| 2| 7| 1| 8| 1| 0| 8| 7| 7| 6| 7| 9| | 1| 2| 7| 9| 2| 9| 5| 9| 2| 8| 8| 2| 7| 0| 8| 2| 6| 1| 7| 1| 0| 4| 1| 2| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + A + + + + + A + + + + + + + A + + + + + + A +| Inflammation, Suppurative | 1 | Mineralization | | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + A + + + + M + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + M + + + + + + + + + + + + + + + + M + +| __________________________________________________________________________| Intestine Large, Cecum | + + A + + + + + A + A + + + + + A + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + A + + + + + M A A + + + + + A + + + + + + A +| __________________________________________________________________________| Intestine Small, Jejunum | + + A + + + + + A + A + + + + + A + + + + + + + +| Peyer's Patch, Hyperplasia | | __________________________________________________________________________| Intestine Small, Ileum | + + A + + + + + A A A + + + + + A + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 | Basophilic Focus | | Degeneration, Fatty | | Eosinophilic Focus | X | Hematopoietic Cell Proliferation | | Hepatodiaphragmatic Nodule | X | Infiltration Cellular, Mast Cell | 2 | Inflammation, Chronic | | Necrosis | 4 1 | Bile Duct, Cyst | 2 2 | Centrilobular, Necrosis | | __________________________________________________________________________| Mesentery | + + + + | Artery, Inflammation, Chronic Active | 4 | Fat, Necrosis | 3 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | Cytoplasmic Alteration | 1 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 | Infiltration Cellular, Mast Cell | 1 | Necrosis | 1 1 | Epithelium, Hyperplasia | 2 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Necrosis | 2 | Epithelium, Hyperplasia | 3 | __________________________________________________________________________| Tooth | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | | Mineralization | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 46 NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 _____________________________________________________________________________________________________________________ | 9| 9| 6| 7| 9| 8| 6| 4| 7| 6| 8| 9| 8| 6| 7| 9| 7| 9| 8| 5| 6| 8| 5| 5| 7| DAY ON TEST | 1| 1| 7| 4| 1| 1| 6| 6| 3| 2| 3| 1| 0| 2| 7| 1| 8| 1| 0| 8| 7| 7| 6| 7| 9| | 1| 2| 7| 9| 2| 9| 5| 9| 2| 8| 8| 2| 7| 0| 8| 2| 6| 1| 7| 1| 0| 4| 1| 2| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Necrosis | | Artery, Inflammation, Chronic Active | 2 | Atrium, Thrombosis | 3 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 3 2 2| Hypertrophy | 2 1 1 1 | Capsule, Hyperplasia | 3 4 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 | __________________________________________________________________________| Parathyroid Gland | + M + + + + + + M + M + M M + M M + + + + M + I M| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + I + + + + + + + + + + +| Pars Distalis, Hyperplasia | 3 | Pars Intermedia, Hyperplasia | 1 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Hyperplasia | 2 2 3 4 2 1 2 3 2 1 1 1 2 1 2 1 1 2| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 2 | __________________________________________________________________________| Penis | + + + + + + | Inflammation, Suppurative | 2 1 3 1 | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + M + + + + + + + + + + + +| Cyst | 3 3 2 | Hyperplasia | 4 | Inflammation, Chronic Active | 3 4 | __________________________________________________________________________| Prostate | + + + + + + + M + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 2 2 2 | Artery, Inflammation, Chronic Active | 2 | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | Inflammation, Suppurative | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 | Mineralization | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 47 NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 _____________________________________________________________________________________________________________________ | 9| 9| 6| 7| 9| 8| 6| 4| 7| 6| 8| 9| 8| 6| 7| 9| 7| 9| 8| 5| 6| 8| 5| 5| 7| DAY ON TEST | 1| 1| 7| 4| 1| 1| 6| 6| 3| 2| 3| 1| 0| 2| 7| 1| 8| 1| 0| 8| 7| 7| 6| 7| 9| | 1| 2| 7| 9| 2| 9| 5| 9| 2| 8| 8| 2| 7| 0| 8| 2| 6| 1| 7| 1| 0| 4| 1| 2| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Hyperplasia | 4 | Hyperplasia, Megakaryocyte | | Hyperplasia | 2 3 | Infiltration Cellular, Mast Cell | 4 | __________________________________________________________________________| Lymph Node | + + +| Congestion | | Iliac, Hyperplasia | 2 2 | Renal, Hyperplasia | 2 | __________________________________________________________________________| Lymph Node, Bronchial | M M M M + + M + + M + + + + M + M + M + M M + M M| Hyperplasia | 2 | __________________________________________________________________________| Lymph Node, Mandibular | M + + M + + M + M + M + + M + + + + M + + + + + M| Infiltration Cellular, Mast Cell | 4 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + M + + + + M I + +| Angiectasis | 2 | Hyperplasia | 2 | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + + + + M + + + M + + + + + + + M +| Hyperplasia | 2 2 2 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Hematopoietic Cell Proliferation | 2 2 1 2 2 2 | Hyperplasia, Lymphoid | | Infiltration Cellular, Mast Cell | 4 | __________________________________________________________________________| Thymus | M M M + + M M + M + M + M + M M M + M M M + M I +| Atrophy | 4 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M I| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Prepuce, Inflammation, Chronic Active| 4 4 4 3 4 4 4 4 4 3 4 4 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | | __________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hydrocephalus | | Artery, Inflammation, Chronic Active | 1 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 1 1 1 1 1 1 1 1 1 | Inflammation, Chronic Active | 1 1 1 1| _____________________________________________________________________________________________________________________| Page 48 NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 _____________________________________________________________________________________________________________________ | 9| 9| 6| 7| 9| 8| 6| 4| 7| 6| 8| 9| 8| 6| 7| 9| 7| 9| 8| 5| 6| 8| 5| 5| 7| DAY ON TEST | 1| 1| 7| 4| 1| 1| 6| 6| 3| 2| 3| 1| 0| 2| 7| 1| 8| 1| 0| 8| 7| 7| 6| 7| 9| | 1| 2| 7| 9| 2| 9| 5| 9| 2| 8| 8| 2| 7| 0| 8| 2| 6| 1| 7| 1| 0| 4| 1| 2| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Inflammation, Suppurative | 2 1 | Epiglottis, Hyperplasia | 1 1 | Epiglottis, Metaplasia, Squamous | 1 1 1 1 1 1 2 1| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar Epithelium, Hyperplasia | 4 | Alveolar Epithelium, Metaplasia | 2 3 4 2 2 3 3 2 2 3 2 2 2 3 1 3 2 2 2 2 3 2 3| Alveolus, Infiltration Cellular, | | Histiocyte | 2 1 3 1 1 2 2 4 1 2 1 1 1 4 2 2 1 2 1 1| Bronchiole, Metaplasia | 1 | Bronchiole, Necrosis | 1 | Perivascular, Infiltration Cellular | 2 3 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Lateral Wall, Degeneration, Hyaline | 3 3 2 1 2 2 2 3 2 2 3 3 2 2 3 2 2 3 2 3 2 2 3 3 3| Lateral Wall, Fibrosis | 1 1 1 2 1 1 2 1 2 1 1 1 1 1 1 1 2 2 1 2 2 1| Lateral Wall, Hyperplasia | 1 2 2 2 1 1 3 2 2 2 1 2 2 2 2 2 2 2 1 1 1 2 2| Lateral Wall, Inflammation, | | Suppurative | 1 1 2 2 1 1 1 1 1 1 1 1 1 1 2 1 1 2 1 1 2 1 2| Lateral Wall, Metaplasia, Squamous | 1 1 2 2 1 1 1 1 1 1 | Nasolacrimal Duct, Inflammation, | | Suppurative | | Olfactory Epithelium, Atrophy | 2 3 2 1 2 1 2 2 3 2 1 1 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| Metaplasia, Squamous | | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | Inflammation | | __________________________________________________________________________| Harderian Gland | + + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 1 | Infarct | | Nephropathy | 1 1 1 1 1 2 1 1 2 1 1 2 1 1 1 1| Cortex, Inflammation, Suppurative | 2 2 2 | Papilla, Inflammation, Suppurative | 1 2 2 1 1 | Pelvis, Dilatation | 2 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + A + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 4 | Inflammation, Suppurative | 2 4 4 1 | Transitional Epithelium, Hyperplasia | 3 | _____________________________________________________________________________________________________________________| Page 49 NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 __________________________________________________________________________________________________________________________________ | 8| 2| 6| 6| 9| 9| 5| 8| 6| 8| 4| 9| 7| 6| 9| 8| 9| 7| 8| 6| 6| 8| 4| 9| 7| | DAY ON TEST | 3| 9| 1| 2| 1| 1| 5| 0| 8| 1| 3| 1| 4| 7| 1| 7| 1| 3| 2| 0| 7| 7| 0| 1| 1| | | 2| 7| 6| 3| 2| 2| 0| 8| 5| 2| 5| 1| 1| 7| 2| 7| 1| 0| 8| 9| 8| 5| 8| 2| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | A + + + + + A + + + + + + A + + + + + + A + A + A| 40 | Inflammation, Suppurative | 1 | 2 1.0| Mineralization | 2 | 1 2.0| __________________________________________________________________________|____________| Intestine Large, Colon | A + + + + + A + + + + + + + + + + + + + A + A + A| 43 | __________________________________________________________________________|____________| Intestine Large, Rectum | A + + + + + + + + + + + + + + + + + + + A + A + A| 44 | __________________________________________________________________________|____________| Intestine Large, Cecum | A + + + + + A A + + + + + + + + + + + + A + A + A| 40 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + A A + + A + + + + + + + + + A + A + A| 38 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + A + + + A + + + + + + + + + A + A + A| 41 | Peyer's Patch, Hyperplasia | 2 2 | 2 2.0| __________________________________________________________________________|____________| Intestine Small, Ileum | A + + + + + A + + + + + + + + + + + + + A + A + A| 40 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | | 1 1.0| Basophilic Focus | X X | 2 | Degeneration, Fatty | 2 2 | 2 2.0| Eosinophilic Focus | X X | 3 | Hematopoietic Cell Proliferation | 1 | 1 1.0| Hepatodiaphragmatic Nodule | | 1 | Infiltration Cellular, Mast Cell | | 1 2.0| Inflammation, Chronic | 1 | 1 1.0| Necrosis | 1 | 3 2.0| Bile Duct, Cyst | | 2 2.0| Centrilobular, Necrosis | 4 | 1 4.0| __________________________________________________________________________|____________| Mesentery | | 4 | Artery, Inflammation, Chronic Active | | 1 4.0| Fat, Necrosis | | 2 2.5| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 | Atrophy | 1 | 1 1.0| Cytoplasmic Alteration | | 1 1.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | | 1 1.0| Infiltration Cellular, Mast Cell | | 1 1.0| Necrosis | 1 | 3 1.0| Epithelium, Hyperplasia | 2 1 | 3 1.7| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + A + + + + + + + + + + + + + A + + + +| 48 | Necrosis | | 1 2.0| Epithelium, Hyperplasia | | 1 3.0| __________________________________________________________________________|____________| Tooth | + | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 50 NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 __________________________________________________________________________________________________________________________________ | 8| 2| 6| 6| 9| 9| 5| 8| 6| 8| 4| 9| 7| 6| 9| 8| 9| 7| 8| 6| 6| 8| 4| 9| 7| | DAY ON TEST | 3| 9| 1| 2| 1| 1| 5| 0| 8| 1| 3| 1| 4| 7| 1| 7| 1| 3| 2| 0| 7| 7| 0| 1| 1| | | 2| 7| 6| 3| 2| 2| 0| 8| 5| 2| 5| 1| 1| 7| 2| 7| 1| 0| 8| 9| 8| 5| 8| 2| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + | 1 | Mineralization | 2 | 1 2.0| __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 2 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 40 1.1| Necrosis | 1 | 1 1.0| Artery, Inflammation, Chronic Active | | 1 2.0| Atrium, Thrombosis | 4 | 2 3.5| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + M + +| 49 | Hyperplasia | 2 1 2 2 | 8 2.1| Hypertrophy | 1 1 1 1 1 2 2 2 1 | 13 1.3| Capsule, Hyperplasia | 3 2 2 3 2 | 7 2.7| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + M + +| 49 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 | Hyperplasia | | 2 2.0| __________________________________________________________________________|____________| Parathyroid Gland | + + + + M M + M M M + + M M M M M M + + M + M M M| 25 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| 48 | Pars Distalis, Hyperplasia | 1 1 | 3 1.7| Pars Intermedia, Hyperplasia | 1 | 2 1.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Follicular Cell, Hyperplasia | 1 1 3 2 1 1 1 1 2 1 2 1 2 2 | 32 1.7| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation | | 1 2.0| __________________________________________________________________________|____________| Penis | + | 7 | Inflammation, Suppurative | 3 | 5 2.0| __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Cyst | 4 2 2 2 2 | 8 2.5| Hyperplasia | | 1 4.0| Inflammation, Chronic Active | 2 3 2 3 3 3 2 | 9 2.8| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + M + + + + + + + + + + A| 47 | Inflammation, Suppurative | | 3 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 51 NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 __________________________________________________________________________________________________________________________________ | 8| 2| 6| 6| 9| 9| 5| 8| 6| 8| 4| 9| 7| 6| 9| 8| 9| 7| 8| 6| 6| 8| 4| 9| 7| | DAY ON TEST | 3| 9| 1| 2| 1| 1| 5| 0| 8| 1| 3| 1| 4| 7| 1| 7| 1| 3| 2| 0| 7| 7| 0| 1| 1| | | 2| 7| 6| 3| 2| 2| 0| 8| 5| 2| 5| 1| 1| 7| 2| 7| 1| 0| 8| 9| 8| 5| 8| 2| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Artery, Inflammation, Chronic Active | | 1 2.0| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | Hyperplasia | 2 | 1 2.0| Inflammation, Suppurative | 4 | 1 4.0| __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 3 1 2 4 | 5 2.4| Mineralization | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | | 1 4.0| Hyperplasia, Megakaryocyte | 2 | 1 2.0| Hyperplasia | 2 | 3 2.3| Infiltration Cellular, Mast Cell | | 1 4.0| __________________________________________________________________________|____________| Lymph Node | + + + + | 7 | Congestion | 2 | 1 2.0| Iliac, Hyperplasia | | 2 2.0| Renal, Hyperplasia | 2 | 2 2.0| __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + + + + + M + + + + + M M + + + + + M + + M| 32 | Hyperplasia | 2 | 2 2.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + M + + + + M M + + I M M + M M M + + + + M +| 32 | Infiltration Cellular, Mast Cell | | 1 4.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + M + + + + + + M + A + +| 44 | Angiectasis | 2 2 2 | 4 2.0| Hyperplasia | 3 2 | 3 2.3| __________________________________________________________________________|____________| Lymph Node, Mediastinal | + M + + + + + + M + M + + + + + + + + + + + + + M| 43 | Hyperplasia | 2 2 | 5 2.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 1 | 1 1.0| Hematopoietic Cell Proliferation | 2 2 3 2 2 2 2 2 4 | 15 2.1| Hyperplasia, Lymphoid | 2 | 1 2.0| Infiltration Cellular, Mast Cell | | 1 4.0| __________________________________________________________________________|____________| Thymus | + + + M + + M + + I + + + + M M + M + M M + I + +| 25 | Atrophy | 4 3 3 2| 5 3.2| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M + M M M M M + M M M M M M M M M M M M M M M M| 2 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Prepuce, Inflammation, Chronic Active| 4 4 3 4| 16 3.8| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 52 NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 __________________________________________________________________________________________________________________________________ | 8| 2| 6| 6| 9| 9| 5| 8| 6| 8| 4| 9| 7| 6| 9| 8| 9| 7| 8| 6| 6| 8| 4| 9| 7| | DAY ON TEST | 3| 9| 1| 2| 1| 1| 5| 0| 8| 1| 3| 1| 4| 7| 1| 7| 1| 3| 2| 0| 7| 7| 0| 1| 1| | | 2| 7| 6| 3| 2| 2| 0| 8| 5| 2| 5| 1| 1| 7| 2| 7| 1| 0| 8| 9| 8| 5| 8| 2| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrous Osteodystrophy | 1 | 1 1.0| __________________________________________________________________________|____________| Skeletal Muscle | + | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hydrocephalus | 2 | 1 2.0| Artery, Inflammation, Chronic Active | | 1 1.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 1 2 2 1 1 | 15 1.1| Inflammation, Chronic Active | 2 1 1 | 7 1.1| Inflammation, Suppurative | 1 2 | 4 1.5| Epiglottis, Hyperplasia | | 2 1.0| Epiglottis, Metaplasia, Squamous | 1 1 | 10 1.1| __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar Epithelium, Hyperplasia | | 1 4.0| Alveolar Epithelium, Metaplasia | 2 2 2 2 2 2 2 2 2 3 2 3 1 2 2 2 2 1 3 2 1 2 2 2| 47 2.2| Alveolus, Infiltration Cellular, | | | Histiocyte | 3 1 2 2 1 1 1 2 1 4 1 1 2 2 3 1 1 1 3 2 1| 41 1.7| Bronchiole, Metaplasia | | 1 1.0| Bronchiole, Necrosis | | 1 1.0| Perivascular, Infiltration Cellular | 2 | 3 2.3| __________________________________________________________________________|____________| Nose | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 | Lateral Wall, Degeneration, Hyaline | 2 3 3 3 3 2 2 2 2 3 2 2 3 2 2 2 3 2 4 3 3 4 2 2| 49 2.5| Lateral Wall, Fibrosis | 1 2 1 2 1 1 1 1 2 1 1 1 1 2 1 1 2 1 1 1 1 | 43 1.3| Lateral Wall, Hyperplasia | 2 1 2 2 2 2 1 2 1 2 2 2 2 2 2 2 2 1 2 3 2 2| 45 1.8| Lateral Wall, Inflammation, | | | Suppurative | 1 2 1 2 2 1 1 1 2 1 1 1 1 2 1 1 1 1 1 1 2 2 1| 46 1.3| Lateral Wall, Metaplasia, Squamous | 1 1 1 1 1 1 2 2 1 1 | 20 1.2| Nasolacrimal Duct, Inflammation, | | | Suppurative | 2 2 | 2 2.0| Olfactory Epithelium, Atrophy | 1 1 1 1 2 2 | 18 1.7| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 | Metaplasia, Squamous | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 53 NTP Experiment-Test: 88034-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 __________________________________________________________________________________________________________________________________ | 8| 2| 6| 6| 9| 9| 5| 8| 6| 8| 4| 9| 7| 6| 9| 8| 9| 7| 8| 6| 6| 8| 4| 9| 7| | DAY ON TEST | 3| 9| 1| 2| 1| 1| 5| 0| 8| 1| 3| 1| 4| 7| 1| 7| 1| 3| 2| 0| 7| 7| 0| 1| 1| | | 2| 7| 6| 3| 2| 2| 0| 8| 5| 2| 5| 1| 1| 7| 2| 7| 1| 0| 8| 9| 8| 5| 8| 2| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Eye | + | 1 | Inflammation | 3 | 1 3.0| __________________________________________________________________________|____________| Harderian Gland | + + + | 5 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 2 | 3 1.7| Infarct | 4 | 1 4.0| Nephropathy | 2 1 1 2 2 1 1 1 1 1 1 1 1 1 1 2 1 3 1 3 1 | 37 1.3| Cortex, Inflammation, Suppurative | | 3 2.0| Papilla, Inflammation, Suppurative | 4 | 6 1.8| Pelvis, Dilatation | | 1 2.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 | Inflammation, Chronic Active | 3 | 2 3.5| Inflammation, Suppurative | 4| 5 3.0| Transitional Epithelium, Hyperplasia | | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 54 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