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TDMS Study 88036-03 Pathology Tables

NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99
Route: DOSED FEED                                                                                                 Time: 11:29:14

                                                       14 WEEK SSAC RATS




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  84-65-1

       Lock Date:  07/23/97

       Cage Range:  All

       Reasons For Removal:    25017 Scheduled Sacrifice

       Removal Date Range:     02/13/95 - 02/14/95

       Treatment Groups:       Include 002    0 PPM
                               Include 010    3750 PPM
                               Include 001    0 PPM
                               Include 009    3750 PPM

































                                                              Page   1



NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:29:14  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0|                                                           |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9|                                                           |            |
                                           | 2| 2| 2| 2| 2|                                                           |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 2| 2| 3| 3| 3|                                                           |      A     |
    0 PPM                                  | 8| 9| 1| 1| 2|                                                           |      L     |
                                           | 7| 8| 0| 9| 9|                                                           |            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  M  +  +  +                                                            |   4        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +                                                            |   5        |
      Inflammation                         | 1                                                                        |      1  1.0|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  M  +  +                                                            |   3        |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +                                                            |   5        |
      Cyst                                 |             1                                                            |      1  1.0|

                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +                                                            |   5        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:29:14  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0|                                                           |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9|                                                           |            |
                                           | 2| 2| 2| 2| 2|                                                           |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 2| 2| 3| 3| 3|                                                           |      A     |
    0 PPM                                  | 8| 9| 1| 1| 2|                                                           |      L     |
                                           | 7| 8| 0| 9| 9|                                                           |            |

 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +                                                            |   5        |
      Nephropathy                          |          1                                                               |      1  1.0|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +                                                            |   5        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:29:14  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0|                                                           |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9|                                                           |            |
                                           | 2| 2| 2| 2| 2|                                                           |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 4| 4| 4| 5| 5|                                                           |      A     |
    3750 PPM                               | 9| 9| 9| 1| 2|                                                           |      L     |
                                           | 0| 1| 6| 4| 7|                                                           |            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +                                                            |   5        |
      Centrilobular, Hypertrophy           | 1  2  2  2  2                                                            |      5  1.8|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +                                                            |   5        |
      Inflammation                         |          1                                                               |      1  1.0|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +                                                            |   5        |
      Erosion                              |       1                                                                  |      1  1.0|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +                                                            |   5        |
      Cardiomyopathy                       |          1                                                               |      1  1.0|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  M                                                            |   3        |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +                                                            |   5        |
      Follicular Cell, Hypertrophy         | 1  1  1  1                                                               |      4  1.0|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:29:14  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0|                                                           |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9|                                                           |            |
                                           | 2| 2| 2| 2| 2|                                                           |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 4| 4| 4| 5| 5|                                                           |      A     |
    3750 PPM                               | 9| 9| 9| 1| 2|                                                           |      L     |
                                           | 0| 1| 6| 4| 7|                                                           |            |

 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +                                                            |   5        |
      Congestion                           | 2  2  2  2  2                                                            |      5  2.0|
      Pigmentation                         | 1  1  2  1                                                               |      4  1.3|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +                                                            |   5        |
      Alveolar Epithelium, Hyperplasia     |    3                                                                     |      1  3.0|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +                                                            |   5        |
      Accumulation, Hyaline Droplet        | 3  3  2  2  3                                                            |      5  2.6|
      Nephropathy                          |    1  1                                                                  |      2  1.0|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +                                                            |   5        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:29:14  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0|                                                           |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9|                                                           |            |
                                           | 2| 2| 2| 2| 2|                                                           |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0|                                                           |      A     |
    0 PPM                                  | 0| 1| 1| 3| 4|                                                           |      L     |
                                           | 3| 0| 5| 1| 6|                                                           |            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +                                                            |   5        |
      Cardiomyopathy                       | 1  1        1                                                            |      3  1.0|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M                                                            |   4        |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +                                                            |   5        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:29:14  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0|                                                           |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9|                                                           |            |
                                           | 2| 2| 2| 2| 2|                                                           |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0|                                                           |      A     |
    0 PPM                                  | 0| 1| 1| 3| 4|                                                           |      L     |
                                           | 3| 0| 5| 1| 6|                                                           |            |

 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +                                                            |   5        |
      Accessory Spleen                     |    X                                                                     |      1     |

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  M  +                                                            |   4        |

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +                                                            |   5        |
      Nephropathy                          | 1  1  1  1  2                                                            |      5  1.2|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +                                                            |   5        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:29:14  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0|                                                           |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9|                                                           |            |
                                           | 2| 2| 2| 2| 2|                                                           |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2|                                                           |      A     |
    3750 PPM                               | 1| 2| 2| 5| 6|                                                           |      L     |
                                           | 7| 1| 4| 0| 3|                                                           |            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +                                                            |   5        |
      Centrilobular, Hypertrophy           | 2  2  2  2  2                                                            |      5  2.0|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +                                                            |   5        |
      Atrophy                              |             1                                                            |      1  1.0|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +                                                            |   5        |
      Cardiomyopathy                       | 1  1        1                                                            |      3  1.0|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  M                                                            |   3        |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +                                                            |   5        |
      Follicular Cell, Hypertrophy         | 1  1  1  1  1                                                            |      5  1.0|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:29:14  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0|                                                           |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9|                                                           |            |
                                           | 2| 2| 2| 2| 2|                                                           |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2|                                                           |      A     |
    3750 PPM                               | 1| 2| 2| 5| 6|                                                           |      L     |
                                           | 7| 1| 4| 0| 3|                                                           |            |

 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +                                                            |   5        |
      Congestion                           | 2  2  2  2  2                                                            |      5  2.0|
      Capsule, Hyperplasia                 |    1                                                                     |      1  1.0|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  M  +  +  +                                                            |   4        |

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +                                                            |   5        |
      Inflammation                         | 1  1     2                                                               |      3  1.3|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +                                                            |   5        |
      Inflammation                         |       1                                                                  |      1  1.0|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +                                                            |   5        |
      Accumulation, Hyaline Droplet        | 3  3  3  3  3                                                            |      5  3.0|
      Nephropathy                          | 2  2  1  1  2                                                            |      5  1.6|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +                                                            |   5        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------