NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Columbus ANTHRAQUINONE DATE: 02/25/99
EXPERIMENT: 88036 TEST: 03 TIME: 11:47:29
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-25337 ROUTE: DOSED FEED NTP C#: C88036
PATHOLOGIST: SINGER, A. CAS: 84-65-1
------------------------------------------------------------------------------------------------------------------------------------
2 YEAR CHRONIC RATS
REASONS FOR REMOVAL: 25019 Moribund Sacrifice
25020 Natural Death
25021 Terminal Sacrifice
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Columbus ANTHRAQUINONE DATE: 02/25/99
EXPERIMENT: 88036 TEST: 03 TIME: 11:47:29
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-25337 ROUTE: DOSED FEED NTP C#: C88036
PATHOLOGIST: SINGER, A. CAS: 84-65-1
Rats(FISCHER 344)
-----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE
BASED ON NUMBER OF TISSUES EXAMINED. IN OTHER TISSUES/ORGANS RATES
ARE BASED ON THE NUMBER OF ANIMALS NECROPSIED.
---------------
Adrenal Cortex
Adrenal Medulla
Brain
Clitoral/Preputial Gland
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Salivary Glands
Spleen
Testes
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Columbus ANTHRAQUINONE DATE: 02/25/99
EXPERIMENT: 88036 TEST: 03 TIME: 11:47:29
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-25337 ROUTE: DOSED FEED NTP C#: C88036
PATHOLOGIST: SINGER, A. CAS: 84-65-1
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF ANTHRAQUINONE
===============================================================
Male Rats
------------
Organ Morphology
----- ----------
Kidney: Renal Tubule Adenoma
Carcinoma or Adenoma
Mammary Gland Fibroadenoma
Fibroma, Fibroadenoma or Adenoma
Fibroma, Fibroadenoma, Carcinoma, or Adenoma
Skin Keratoacanthoma
Squamous Cell Papilloma, Papilloma, Squamous Cell Carcinoma or Keratoacanthoma
Squamous Cell Papilloma, Papilloma, or Keratoacanthoma
Urinary Bladder Carcinoma or Papilloma
Papilloma
All Organs Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated
Mesothelioma: Benign, Malignant, NOS
Mesothelioma: Malignant
Malignant Tumors
===============================================================
Female Rats
------------
Organ Morphology
----- ----------
Clitoral/Preputial Gland Carcinoma or Adenoma
Kidney: Renal Tubule Adenoma
Carcinoma or Adenoma
Liver Hepatocellular Adenoma
Mammary Gland Fibroadenoma
Fibroma, Fibroadenoma or Adenoma
Fibroma, Fibroadenoma, Carcinoma, or Adenoma
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
Thyroid Gland: C-Cell Adenoma
Carcinoma or Adenoma
Urinary Bladder Carcinoma or Papilloma
All Organs Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated
Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
===============================================================
Date: 02/25/99 EXPERIMENT: 88036 TEST: 03 Page 1
Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - ANTHRAQUINONE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 8/50 (16%) 8/50 (16%) 10/50 (20%) 6/50 (12%) 11/50 (22%) |
|POLY-3 ADJUSTED (b)| 19.5% 18.0% 23.1% 13.7% 26.5% |
|TERMINAL (d) | 6/22 (27%) 4/23 (17%) 5/22 (23%) 5/26 (19%) 6/22 (27%) |
|FIRST INCIDENCE | 681 642 643 727 641 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.297 P=0.536N P=0.454 P=0.252N P=0.328 |
|POLY 3 | P=0.276 P=0.539N P=0.446 P=0.336N P=0.310 |
|POLY 1.5 | P=0.276 P=0.570N P=0.421 P=0.361N P=0.299 |
|POLY 6 | P=0.278 P=0.497N P=0.485 P=0.302N P=0.331 |
|LOGISTIC REGRESSION| P=0.263 P=0.505N P=0.496 P=0.238N P=0.312 |
|COCH-ARM / FISHERS | P=0.294 P=0.607N P=0.398 P=0.387N P=0.306 |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 1/50 (2%) 1/50 (2%) 2/49 (4%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 2.2% 2.1% 4.2% |
|TERMINAL (d) | 0/23 (0%) 0/40 (0%) 1/35 (3%) 1/37 (3%) 0/40 (0%) |
|FIRST INCIDENCE | --- --- 730 (T) 730 (T) 536 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.106 (e) P=0.584 P=0.595 P=0.281 |
|POLY 3 | P=0.088 (e) P=0.509 P=0.518 P=0.263 |
|POLY 1.5 | P=0.081 (e) P=0.503 P=0.509 P=0.248 |
|POLY 6 | P=0.099 (e) P=0.520 P=0.531 P=0.287 |
|LOGISTIC REGRESSION| P=0.056 (e) P=0.584 P=0.595 P=0.165 |
|COCH-ARM / FISHERS | P=0.073 (e) P=0.500 P=0.500 P=0.242 |
|=================================================================================================================================|
Date: 02/25/99 EXPERIMENT: 88036 TEST: 03 Page 2
Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - ANTHRAQUINONE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma: Benign, Complex, Malignant, NOS |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 8/50 (16%) 9/50 (18%) 10/50 (20%) 7/50 (14%) 11/50 (22%) |
|POLY-3 ADJUSTED (b)| 19.5% 20.2% 23.1% 16.0% 26.5% |
|TERMINAL (d) | 6/22 (27%) 4/23 (17%) 5/22 (23%) 6/26 (23%) 6/22 (27%) |
|FIRST INCIDENCE | 681 642 643 727 641 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.321 P=0.574 P=0.454 P=0.348N P=0.328 |
|POLY 3 | P=0.301 P=0.574 P=0.446 P=0.446N P=0.310 |
|POLY 1.5 | P=0.300 P=0.541 P=0.421 P=0.473N P=0.299 |
|POLY 6 | P=0.304 P=0.598N P=0.485 P=0.409N P=0.331 |
|LOGISTIC REGRESSION| P=0.286 P=0.603N P=0.496 P=0.331N P=0.312 |
|COCH-ARM / FISHERS | P=0.318 P=0.500 P=0.398 P=0.500N P=0.306 |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma: Benign, Complex, Malignant, NOS |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 2/50 (4%) 1/50 (2%) 2/49 (4%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 4.4% 2.1% 4.2% |
|TERMINAL (d) | 0/23 (0%) 0/40 (0%) 2/35 (6%) 1/37 (3%) 0/40 (0%) |
|FIRST INCIDENCE | --- --- 730 (T) 730 (T) 536 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.177 (e) P=0.335 P=0.595 P=0.281 |
|POLY 3 | P=0.148 (e) P=0.247 P=0.518 P=0.263 |
|POLY 1.5 | P=0.136 (e) P=0.240 P=0.509 P=0.248 |
|POLY 6 | P=0.168 (e) P=0.260 P=0.531 P=0.287 |
|LOGISTIC REGRESSION| P=0.104 (e) P=0.335 P=0.595 P=0.165 |
|COCH-ARM / FISHERS | P=0.124 (e) P=0.247 P=0.500 P=0.242 |
|=================================================================================================================================|
Date: 02/25/99 EXPERIMENT: 88036 TEST: 03 Page 3
Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - ANTHRAQUINONE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Brain |
| Astrocytoma Malignant |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 2/50 (4%) 0/50 (0%) 0/50 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 4.6% 0.0% 0.0% |
|TERMINAL (d) | 0/22 (0%) 0/23 (0%) 1/22 (5%) 0/26 (0%) 0/22 (0%) |
|FIRST INCIDENCE | --- --- 312 --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.516N (e) P=0.240 (e) (e) |
|POLY 3 | P=0.510N (e) P=0.252 (e) (e) |
|POLY 1.5 | P=0.515N (e) P=0.246 (e) (e) |
|POLY 6 | P=0.503N (e) P=0.261 (e) (e) |
|LOGISTIC REGRESSION| P=0.344N (e) P=0.284 (e) (e) |
|COCH-ARM / FISHERS | P=0.516N (e) P=0.247 (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Brain |
| Astrocytoma Malignant |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 1/50 (2%) 1/50 (2%) 0/49 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 2.2% 2.1% 0.0% |
|TERMINAL (d) | 0/23 (0%) 0/40 (0%) 0/35 (0%) 0/37 (0%) 0/40 (0%) |
|FIRST INCIDENCE | --- --- 85 647 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.684N (e) P=0.500 P=0.523 (e) |
|POLY 3 | P=0.676N (e) P=0.513 P=0.519 (e) |
|POLY 1.5 | P=0.688N (e) P=0.507 P=0.510 (e) |
|POLY 6 | P=0.658N (e) P=0.525 P=0.533 (e) |
|LOGISTIC REGRESSION| P=0.563 (e) (e) P=0.403 (e) |
|COCH-ARM / FISHERS | P=0.685 (e) P=0.500 P=0.500 (e) |
|=================================================================================================================================|
Date: 02/25/99 EXPERIMENT: 88036 TEST: 03 Page 4
Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - ANTHRAQUINONE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Brain |
| Oligodendroglioma, Glioma, or Astrocytoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 2/50 (4%) 0/50 (0%) 1/50 (2%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 4.6% 0.0% 2.5% |
|TERMINAL (d) | 0/22 (0%) 0/23 (0%) 1/22 (5%) 0/26 (0%) 0/22 (0%) |
|FIRST INCIDENCE | --- --- 312 --- 671 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.410 (e) P=0.240 (e) P=0.518 |
|POLY 3 | P=0.404 (e) P=0.252 (e) P=0.501 |
|POLY 1.5 | P=0.402 (e) P=0.246 (e) P=0.498 |
|POLY 6 | P=0.407 (e) P=0.261 (e) P=0.504 |
|LOGISTIC REGRESSION| P=0.535 (e) P=0.284 (e) P=0.500 |
|COCH-ARM / FISHERS | P=0.408 (e) P=0.247 (e) P=0.500 |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Brain |
| Oligodendroglioma, Glioma, or Astrocytoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 2/50 (4%) 1/50 (2%) 0/49 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 4.3% 2.1% 0.0% |
|TERMINAL (d) | 0/23 (0%) 0/40 (0%) 0/35 (0%) 0/37 (0%) 0/40 (0%) |
|FIRST INCIDENCE | --- --- 85 647 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.582N (e) P=0.238 P=0.523 (e) |
|POLY 3 | P=0.560N (e) P=0.256 P=0.519 (e) |
|POLY 1.5 | P=0.577N (e) P=0.247 P=0.510 (e) |
|POLY 6 | P=0.534N (e) P=0.271 P=0.533 (e) |
|LOGISTIC REGRESSION| P=0.526 (e) (e) P=0.403 (e) |
|COCH-ARM / FISHERS | P=0.598N (e) P=0.247 P=0.500 (e) |
|=================================================================================================================================|
Date: 02/25/99 EXPERIMENT: 88036 TEST: 03 Page 5
Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - ANTHRAQUINONE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 3/50 (6%) 9/49 (18%) 7/50 (14%) 4/49 (8%) 2/50 (4%) |
|POLY-3 ADJUSTED (b)| 7.3% 20.5% 16.2% 9.2% 4.9% |
|TERMINAL (d) | 2/22 (9%) 5/23 (22%) 3/22 (14%) 2/25 (8%) 2/22 (9%) |
|FIRST INCIDENCE | 565 597 643 628 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.096N P=0.087 P=0.196 P=0.567 P=0.498N |
|POLY 3 | P=0.092N P=0.072 P=0.175 P=0.527 P=0.507N |
|POLY 1.5 | P=0.094N P=0.064 P=0.166 P=0.508 P=0.508N |
|POLY 6 | P=0.089N P=0.085 P=0.192 P=0.556 P=0.505N |
|LOGISTIC REGRESSION| P=0.095N P=0.068 P=0.176 P=0.490 P=0.500N |
|COCH-ARM / FISHERS | P=0.091N P=0.056 P=0.159 P=0.489 P=0.500N |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 3/49 (6%) 3/46 (7%) 4/48 (8%) 2/49 (4%) 1/48 (2%) |
|POLY-3 ADJUSTED (b)| 7.0% 6.9% 9.3% 4.3% 2.1% |
|TERMINAL (d) | 1/23 (4%) 3/39 (8%) 3/34 (9%) 2/37 (5%) 0/38 (0%) |
|FIRST INCIDENCE | 689 730 (T) 723 730 (T) 536 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.094N P=0.443N P=0.615N P=0.319N P=0.198N |
|POLY 3 | P=0.132N P=0.655N P=0.503 P=0.467N P=0.275N |
|POLY 1.5 | P=0.143N P=0.652 P=0.491 P=0.482N P=0.292N |
|POLY 6 | P=0.116N P=0.624N P=0.528 P=0.441N P=0.248N |
|LOGISTIC REGRESSION| P=0.149N P=0.608N P=0.564 P=0.429N P=0.394N |
|COCH-ARM / FISHERS | P=0.157N P=0.631 P=0.488 P=0.500N P=0.316N |
|=================================================================================================================================|
Date: 02/25/99 EXPERIMENT: 88036 TEST: 03 Page 6
Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - ANTHRAQUINONE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 1/50 (2%) 1/49 (2%) 2/50 (4%) 5/49 (10%) 3/50 (6%) |
|POLY-3 ADJUSTED (b)| 2.4% 2.3% 4.6% 11.7% 7.3% |
|TERMINAL (d) | 0/22 (0%) 1/23 (4%) 0/22 (0%) 3/25 (12%) 1/22 (5%) |
|FIRST INCIDENCE | 648 729 (T) 603 690 607 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.124 P=0.738N P=0.523 P=0.152 P=0.322 |
|POLY 3 | P=0.114 P=0.750N P=0.518 P=0.111 P=0.306 |
|POLY 1.5 | P=0.116 P=0.757N P=0.509 P=0.104 P=0.302 |
|POLY 6 | P=0.112 P=0.742N P=0.530 P=0.122 P=0.312 |
|LOGISTIC REGRESSION| P=0.119 P=0.764N P=0.493 P=0.123 P=0.305 |
|COCH-ARM / FISHERS | P=0.127 P=0.747 P=0.500 P=0.098 P=0.309 |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 2/49 (4%) 1/46 (2%) 2/48 (4%) 0/49 (0%) 0/48 (0%) |
|POLY-3 ADJUSTED (b)| 4.7% 2.3% 4.6% 0.0% 0.0% |
|TERMINAL (d) | 0/23 (0%) 0/39 (0%) 0/34 (0%) 0/37 (0%) 0/38 (0%) |
|FIRST INCIDENCE | 702 645 571 --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.083N P=0.408N P=0.624N P=0.166N P=0.146N |
|POLY 3 | P=0.097N P=0.491N P=0.685N P=0.221N P=0.220N |
|POLY 1.5 | P=0.099N P=0.506N P=0.691 P=0.228N P=0.231N |
|POLY 6 | P=0.095N P=0.465N P=0.664N P=0.208N P=0.204N |
|LOGISTIC REGRESSION| P=0.113N P=0.559N P=0.692N P=0.216N P=0.221N |
|COCH-ARM / FISHERS | P=0.102N P=0.524N P=0.684 P=0.247N P=0.253N |
|=================================================================================================================================|
Date: 02/25/99 EXPERIMENT: 88036 TEST: 03 Page 7
Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - ANTHRAQUINONE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma or Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 4/50 (8%) 10/49 (20%) 9/50 (18%) 9/49 (18%) 5/50 (10%) |
|POLY-3 ADJUSTED (b)| 9.6% 22.8% 20.6% 20.7% 12.1% |
|TERMINAL (d) | 2/22 (9%) 6/23 (26%) 3/22 (14%) 5/25 (20%) 3/22 (14%) |
|FIRST INCIDENCE | 565 597 603 628 607 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.391N P=0.108 P=0.158 P=0.190 P=0.512 |
|POLY 3 | P=0.399N P=0.086 P=0.133 P=0.131 P=0.495 |
|POLY 1.5 | P=0.399N P=0.077 P=0.124 P=0.119 P=0.491 |
|POLY 6 | P=0.398N P=0.099 P=0.149 P=0.151 P=0.501 |
|LOGISTIC REGRESSION| P=0.397N P=0.081 P=0.124 P=0.123 P=0.496 |
|COCH-ARM / FISHERS | P=0.376N P=0.068 P=0.117 P=0.109 P=0.500 |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma or Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 5/49 (10%) 4/46 (9%) 6/48 (13%) 2/49 (4%) 1/48 (2%) |
|POLY-3 ADJUSTED (b)| 11.6% 9.1% 13.7% 4.3% 2.1% |
|TERMINAL (d) | 1/23 (4%) 3/39 (8%) 3/34 (9%) 2/37 (5%) 0/38 (0%) |
|FIRST INCIDENCE | 689 645 571 730 (T) 536 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.021N* P=0.275N P=0.547N P=0.095N P=0.043N* |
|POLY 3 | P=0.032N* P=0.488N P=0.513 P=0.188N P=0.083N |
|POLY 1.5 | P=0.036N* P=0.513N P=0.493 P=0.201N P=0.094N |
|POLY 6 | P=0.027N* P=0.445N P=0.551 P=0.169N P=0.069N |
|LOGISTIC REGRESSION| P=0.046N* P=0.506N P=0.489 P=0.162N P=0.149N |
|COCH-ARM / FISHERS | P=0.042N* P=0.541N P=0.485 P=0.218N P=0.107N |
|=================================================================================================================================|
Date: 02/25/99 EXPERIMENT: 88036 TEST: 03 Page 8
Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - ANTHRAQUINONE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 1/49 (2%) 0/50 (0%) 2/50 (4%) 0/50 (0%) 0/50 (0%) |
|POLY-3 ADJUSTED (b)| 2.5% 0.0% 4.7% 0.0% 0.0% |
|TERMINAL (d) | 0/21 (0%) 0/23 (0%) 2/22 (9%) 0/26 (0%) 0/22 (0%) |
|FIRST INCIDENCE | 642 --- 729 (T) --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.274N P=0.471N P=0.520 P=0.485N P=0.505N |
|POLY 3 | P=0.278N P=0.483N P=0.522 P=0.482N P=0.497N |
|POLY 1.5 | P=0.278N P=0.488N P=0.515 P=0.489N P=0.498N |
|POLY 6 | P=0.277N P=0.475N P=0.534 P=0.473N P=0.495N |
|LOGISTIC REGRESSION| P=0.277N P=0.530N P=0.530 P=0.503N P=0.488N |
|COCH-ARM / FISHERS | P=0.275N P=0.495N P=0.508 P=0.495N P=0.495N |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/49 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/49 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/23 (0%) 0/40 (0%) 0/35 (0%) 0/37 (0%) 0/40 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 02/25/99 EXPERIMENT: 88036 TEST: 03 Page 9
Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - ANTHRAQUINONE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Carcinoma or Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 2/49 (4%) 0/50 (0%) 3/50 (6%) 0/50 (0%) 0/50 (0%) |
|POLY-3 ADJUSTED (b)| 4.9% 0.0% 7.0% 0.0% 0.0% |
|TERMINAL (d) | 0/21 (0%) 0/23 (0%) 3/22 (14%) 0/26 (0%) 0/22 (0%) |
|FIRST INCIDENCE | 562 --- 729 (T) --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.134N P=0.217N P=0.523 P=0.224N P=0.243N |
|POLY 3 | P=0.139N P=0.221N P=0.523 P=0.220N P=0.236N |
|POLY 1.5 | P=0.138N P=0.226N P=0.516 P=0.227N P=0.237N |
|POLY 6 | P=0.139N P=0.214N P=0.534 P=0.212N P=0.236N |
|LOGISTIC REGRESSION| P=0.135N P=0.295N P=0.509 P=0.224N P=0.196N |
|COCH-ARM / FISHERS | P=0.136N P=0.242N P=0.510 P=0.242N P=0.242N |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Carcinoma or Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/49 (0%) 1/50 (2%) 1/50 (2%) 0/50 (0%) 0/49 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 2.2% 2.2% 0.0% 0.0% |
|TERMINAL (d) | 0/23 (0%) 1/40 (3%) 0/35 (0%) 0/37 (0%) 0/40 (0%) |
|FIRST INCIDENCE | --- 730 (T) 718 --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.348N P=0.610 P=0.576 (e) (e) |
|POLY 3 | P=0.386N P=0.518 P=0.512 (e) (e) |
|POLY 1.5 | P=0.397N P=0.511 P=0.506 (e) (e) |
|POLY 6 | P=0.370N P=0.531 P=0.523 (e) (e) |
|LOGISTIC REGRESSION| P=0.368N P=0.610 P=0.530 (e) (e) |
|COCH-ARM / FISHERS | P=0.408N P=0.505 P=0.505 (e) (e) |
|=================================================================================================================================|
Date: 02/25/99 EXPERIMENT: 88036 TEST: 03 Page 10
Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - ANTHRAQUINONE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Kidney: Pelvis and Transitional Epithelium |
| Papilloma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 2/50 (4%) 0/50 (0%) 1/50 (2%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 4.7% 0.0% 2.5% |
|TERMINAL (d) | 0/22 (0%) 0/23 (0%) 0/22 (0%) 0/26 (0%) 1/22 (5%) |
|FIRST INCIDENCE | --- --- 638 --- 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.399 (e) P=0.260 (e) P=0.500 |
|POLY 3 | P=0.401 (e) P=0.249 (e) P=0.500 |
|POLY 1.5 | P=0.400 (e) P=0.243 (e) P=0.498 |
|POLY 6 | P=0.403 (e) P=0.259 (e) P=0.502 |
|LOGISTIC REGRESSION| P=0.401 (e) P=0.238 (e) P=0.500 |
|COCH-ARM / FISHERS | P=0.408 (e) P=0.247 (e) P=0.500 |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Kidney: Pelvis and Transitional Epithelium |
| Papilloma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/49 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/23 (0%) 0/40 (0%) 0/35 (0%) 0/37 (0%) 0/40 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 02/25/99 EXPERIMENT: 88036 TEST: 03 Page 11
Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - ANTHRAQUINONE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 1/50 (2%) 3/50 (6%) 9/50 (18%) 5/50 (10%) 3/50 (6%) |
|POLY-3 ADJUSTED (b)| 2.5% 6.8% 20.7% 11.4% 7.3% |
|TERMINAL (d) | 1/22 (5%) 1/23 (4%) 3/22 (14%) 3/26 (12%) 1/22 (5%) |
|FIRST INCIDENCE | 729 (T) 669 648 690 641 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.474 P=0.339 P=0.018 * P=0.159 P=0.319 |
|POLY 3 | P=0.474 P=0.333 P=0.010 * P=0.119 P=0.308 |
|POLY 1.5 | P=0.469 P=0.320 P=0.009 ** P=0.110 P=0.303 |
|POLY 6 | P=0.485 P=0.349 P=0.013 * P=0.133 P=0.316 |
|LOGISTIC REGRESSION| P=0.467 P=0.351 P=0.013 * P=0.147 P=0.305 |
|COCH-ARM / FISHERS | P=0.485 P=0.309 P=0.008 ** P=0.102 P=0.309 |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/50 (0%) 4/50 (8%) 9/50 (18%) 7/50 (14%) 12/49 (24%) |
|POLY-3 ADJUSTED (b)| 0.0% 8.6% 19.8% 14.8% 25.2% |
|TERMINAL (d) | 0/23 (0%) 4/40 (10%) 8/35 (23%) 5/37 (14%) 9/40 (23%) |
|FIRST INCIDENCE | --- 730 (T) 570 635 689 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.005 ** P=0.153 P=0.011 * P=0.036 * P=0.007 ** |
|POLY 3 | P<0.001 ** P=0.071 P=0.002 ** P=0.011 * P<0.001 ** |
|POLY 1.5 | P<0.001 ** P=0.066 P=0.002 ** P=0.009 ** P<0.001 ** |
|POLY 6 | P=0.002 ** P=0.081 P=0.003 ** P=0.015 * P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** P=0.153 P=0.003 ** P=0.014 * P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** P=0.059 P<0.001 ** P=0.006 ** P<0.001 ** |
|=================================================================================================================================|
Date: 02/25/99 EXPERIMENT: 88036 TEST: 03 Page 12
Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - ANTHRAQUINONE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Carcinoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/22 (0%) 0/23 (0%) 0/22 (0%) 0/26 (0%) 0/22 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Carcinoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 0/50 (0%) 1/50 (2%) 2/49 (4%) |
|POLY-3 ADJUSTED (b)| 0.0% 4.3% 0.0% 2.1% 4.2% |
|TERMINAL (d) | 0/23 (0%) 2/40 (5%) 0/35 (0%) 0/37 (0%) 2/40 (5%) |
|FIRST INCIDENCE | --- 730 (T) --- 611 730 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.284 P=0.367 (e) P=0.517 P=0.367 |
|POLY 3 | P=0.242 P=0.255 (e) P=0.519 P=0.259 |
|POLY 1.5 | P=0.228 P=0.246 (e) P=0.510 P=0.246 |
|POLY 6 | P=0.266 P=0.271 (e) P=0.534 P=0.281 |
|LOGISTIC REGRESSION| P=0.210 P=0.367 (e) P=0.354 P=0.367 |
|COCH-ARM / FISHERS | P=0.211 P=0.247 (e) P=0.500 P=0.242 |
|=================================================================================================================================|
Date: 02/25/99 EXPERIMENT: 88036 TEST: 03 Page 13
Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - ANTHRAQUINONE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Carcinoma or Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 1/50 (2%) 3/50 (6%) 9/50 (18%) 5/50 (10%) 3/50 (6%) |
|POLY-3 ADJUSTED (b)| 2.5% 6.8% 20.7% 11.4% 7.3% |
|TERMINAL (d) | 1/22 (5%) 1/23 (4%) 3/22 (14%) 3/26 (12%) 1/22 (5%) |
|FIRST INCIDENCE | 729 (T) 669 648 690 641 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.474 P=0.339 P=0.018 * P=0.159 P=0.319 |
|POLY 3 | P=0.474 P=0.333 P=0.010 * P=0.119 P=0.308 |
|POLY 1.5 | P=0.469 P=0.320 P=0.009 ** P=0.110 P=0.303 |
|POLY 6 | P=0.485 P=0.349 P=0.013 * P=0.133 P=0.316 |
|LOGISTIC REGRESSION| P=0.467 P=0.351 P=0.013 * P=0.147 P=0.305 |
|COCH-ARM / FISHERS | P=0.485 P=0.309 P=0.008 ** P=0.102 P=0.309 |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Carcinoma or Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/50 (0%) 6/50 (12%) 9/50 (18%) 8/50 (16%) 14/49 (29%) |
|POLY-3 ADJUSTED (b)| 0.0% 12.9% 19.8% 16.7% 29.5% |
|TERMINAL (d) | 0/23 (0%) 6/40 (15%) 8/35 (23%) 5/37 (14%) 11/40 (28%) |
|FIRST INCIDENCE | --- 730 (T) 570 611 689 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.003 ** P=0.067 P=0.011 * P=0.022 * P=0.003 ** |
|POLY 3 | P<0.001 ** P=0.020 * P=0.002 ** P=0.006 ** P<0.001 ** |
|POLY 1.5 | P<0.001 ** P=0.018 * P=0.002 ** P=0.005 ** P<0.001 ** |
|POLY 6 | P<0.001 ** P=0.024 * P=0.003 ** P=0.008 ** P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** P=0.067 P=0.003 ** P=0.004 ** P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** P=0.013 * P<0.001 ** P=0.003 ** P<0.001 ** |
|=================================================================================================================================|
Date: 02/25/99 EXPERIMENT: 88036 TEST: 03 Page 14
Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - ANTHRAQUINONE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 1/50 (2%) 3/50 (6%) 4/50 (8%) 4/50 (8%) 2/50 (4%) |
|POLY-3 ADJUSTED (b)| 2.5% 6.9% 9.4% 9.1% 4.9% |
|TERMINAL (d) | 1/22 (5%) 3/23 (13%) 4/22 (18%) 4/26 (15%) 2/22 (9%) |
|FIRST INCIDENCE | 729 (T) 729 (T) 729 (T) 729 (T) 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.545 P=0.318 P=0.174 P=0.229 P=0.500 |
|POLY 3 | P=0.518 P=0.330 P=0.192 P=0.200 P=0.499 |
|POLY 1.5 | P=0.518 P=0.319 P=0.185 P=0.190 P=0.496 |
|POLY 6 | P=0.519 P=0.345 P=0.203 P=0.217 P=0.504 |
|LOGISTIC REGRESSION| P=0.545 P=0.318 P=0.174 P=0.229 P=0.500 |
|COCH-ARM / FISHERS | P=0.534 P=0.309 P=0.181 P=0.181 P=0.500 |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 6/50 (12%) 4/50 (8%) 3/49 (6%) |
|POLY-3 ADJUSTED (b)| 0.0% 4.3% 13.3% 8.5% 6.4% |
|TERMINAL (d) | 0/23 (0%) 2/40 (5%) 5/35 (14%) 3/37 (8%) 3/40 (8%) |
|FIRST INCIDENCE | --- 730 (T) 676 723 730 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.397 P=0.367 P=0.048 * P=0.143 P=0.234 |
|POLY 3 | P=0.298 P=0.255 P=0.018 * P=0.072 P=0.136 |
|POLY 1.5 | P=0.267 P=0.246 P=0.016 * P=0.067 P=0.126 |
|POLY 6 | P=0.351 P=0.271 P=0.022 * P=0.083 P=0.156 |
|LOGISTIC REGRESSION| P=0.362 P=0.367 P=0.027 * P=0.121 P=0.234 |
|COCH-ARM / FISHERS | P=0.236 P=0.247 P=0.013 * P=0.059 P=0.117 |
|=================================================================================================================================|
Date: 02/25/99 EXPERIMENT: 88036 TEST: 03 Page 15
Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - ANTHRAQUINONE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 1/50 (2%) 3/50 (6%) 4/50 (8%) 5/50 (10%) 3/50 (6%) |
|POLY-3 ADJUSTED (b)| 2.5% 6.9% 9.4% 11.4% 7.3% |
|TERMINAL (d) | 1/22 (5%) 3/23 (13%) 4/22 (18%) 5/26 (19%) 2/22 (9%) |
|FIRST INCIDENCE | 729 (T) 729 (T) 729 (T) 729 (T) 607 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.322 P=0.318 P=0.174 P=0.139 P=0.310 |
|POLY 3 | P=0.310 P=0.330 P=0.192 P=0.118 P=0.307 |
|POLY 1.5 | P=0.308 P=0.319 P=0.185 P=0.110 P=0.303 |
|POLY 6 | P=0.314 P=0.345 P=0.203 P=0.130 P=0.314 |
|LOGISTIC REGRESSION| P=0.292 P=0.318 P=0.174 P=0.139 P=0.306 |
|COCH-ARM / FISHERS | P=0.321 P=0.309 P=0.181 P=0.102 P=0.309 |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 1/50 (2%) 2/50 (4%) 6/50 (12%) 4/50 (8%) 3/49 (6%) |
|POLY-3 ADJUSTED (b)| 2.3% 4.3% 13.3% 8.5% 6.4% |
|TERMINAL (d) | 0/23 (0%) 2/40 (5%) 5/35 (14%) 3/37 (8%) 3/40 (8%) |
|FIRST INCIDENCE | 571 730 (T) 676 723 730 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.508 P=0.626 P=0.126 P=0.315 P=0.458 |
|POLY 3 | P=0.398 P=0.523 P=0.062 P=0.203 P=0.335 |
|POLY 1.5 | P=0.368 P=0.511 P=0.057 P=0.192 P=0.317 |
|POLY 6 | P=0.448 P=0.543 P=0.071 P=0.223 P=0.367 |
|LOGISTIC REGRESSION| P=0.392 P=0.457 P=0.060 P=0.156 P=0.247 |
|COCH-ARM / FISHERS | P=0.336 P=0.500 P=0.056 P=0.181 P=0.301 |
|=================================================================================================================================|
Date: 02/25/99 EXPERIMENT: 88036 TEST: 03 Page 16
Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - ANTHRAQUINONE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, |
| or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 1/50 (2%) 3/50 (6%) 4/50 (8%) 5/50 (10%) 3/50 (6%) |
|POLY-3 ADJUSTED (b)| 2.5% 6.9% 9.4% 11.4% 7.3% |
|TERMINAL (d) | 1/22 (5%) 3/23 (13%) 4/22 (18%) 5/26 (19%) 2/22 (9%) |
|FIRST INCIDENCE | 729 (T) 729 (T) 729 (T) 729 (T) 607 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.322 P=0.318 P=0.174 P=0.139 P=0.310 |
|POLY 3 | P=0.310 P=0.330 P=0.192 P=0.118 P=0.307 |
|POLY 1.5 | P=0.308 P=0.319 P=0.185 P=0.110 P=0.303 |
|POLY 6 | P=0.314 P=0.345 P=0.203 P=0.130 P=0.314 |
|LOGISTIC REGRESSION| P=0.292 P=0.318 P=0.174 P=0.139 P=0.306 |
|COCH-ARM / FISHERS | P=0.321 P=0.309 P=0.181 P=0.102 P=0.309 |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, |
| or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 1/50 (2%) 2/50 (4%) 6/50 (12%) 4/50 (8%) 3/49 (6%) |
|POLY-3 ADJUSTED (b)| 2.3% 4.3% 13.3% 8.5% 6.4% |
|TERMINAL (d) | 0/23 (0%) 2/40 (5%) 5/35 (14%) 3/37 (8%) 3/40 (8%) |
|FIRST INCIDENCE | 571 730 (T) 676 723 730 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.508 P=0.626 P=0.126 P=0.315 P=0.458 |
|POLY 3 | P=0.398 P=0.523 P=0.062 P=0.203 P=0.335 |
|POLY 1.5 | P=0.368 P=0.511 P=0.057 P=0.192 P=0.317 |
|POLY 6 | P=0.448 P=0.543 P=0.071 P=0.223 P=0.367 |
|LOGISTIC REGRESSION| P=0.392 P=0.457 P=0.060 P=0.156 P=0.247 |
|COCH-ARM / FISHERS | P=0.336 P=0.500 P=0.056 P=0.181 P=0.301 |
|=================================================================================================================================|
Date: 02/25/99 EXPERIMENT: 88036 TEST: 03 Page 17
Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - ANTHRAQUINONE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 2/50 (4%) 2/50 (4%) 0/50 (0%) 2/50 (4%) 0/50 (0%) |
|POLY-3 ADJUSTED (b)| 4.9% 4.6% 0.0% 4.6% 0.0% |
|TERMINAL (d) | 1/22 (5%) 2/23 (9%) 0/22 (0%) 1/26 (4%) 0/22 (0%) |
|FIRST INCIDENCE | 665 729 (T) --- 719 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.180N P=0.670N P=0.230N P=0.629N P=0.233N |
|POLY 3 | P=0.192N P=0.671N P=0.228N P=0.670N P=0.238N |
|POLY 1.5 | P=0.191N P=0.681N P=0.233N P=0.682N P=0.240N |
|POLY 6 | P=0.194N P=0.659N P=0.221N P=0.653N P=0.236N |
|LOGISTIC REGRESSION| P=0.185N P=0.649N P=0.226N P=0.648N P=0.237N |
|COCH-ARM / FISHERS | P=0.185N P=0.691N P=0.247N P=0.691N P=0.247N |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 2/50 (4%) 0/50 (0%) 0/48 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 2.1% 4.4% 0.0% 0.0% |
|TERMINAL (d) | 0/23 (0%) 0/40 (0%) 2/35 (6%) 0/37 (0%) 0/40 (0%) |
|FIRST INCIDENCE | --- 592 730 (T) --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.304N P=0.504 P=0.335 (e) (e) |
|POLY 3 | P=0.328N P=0.517 P=0.247 (e) (e) |
|POLY 1.5 | P=0.342N P=0.509 P=0.240 (e) (e) |
|POLY 6 | P=0.306N P=0.532 P=0.260 (e) (e) |
|LOGISTIC REGRESSION| P=0.381N P=0.484 P=0.335 (e) (e) |
|COCH-ARM / FISHERS | P=0.359N P=0.500 P=0.247 (e) (e) |
|=================================================================================================================================|
Date: 02/25/99 EXPERIMENT: 88036 TEST: 03 Page 18
Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - ANTHRAQUINONE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 2/50 (4%) 2/50 (4%) 0/50 (0%) 2/50 (4%) 0/50 (0%) |
|POLY-3 ADJUSTED (b)| 4.9% 4.6% 0.0% 4.6% 0.0% |
|TERMINAL (d) | 1/22 (5%) 2/23 (9%) 0/22 (0%) 1/26 (4%) 0/22 (0%) |
|FIRST INCIDENCE | 665 729 (T) --- 719 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.180N P=0.670N P=0.230N P=0.629N P=0.233N |
|POLY 3 | P=0.192N P=0.671N P=0.228N P=0.670N P=0.238N |
|POLY 1.5 | P=0.191N P=0.681N P=0.233N P=0.682N P=0.240N |
|POLY 6 | P=0.194N P=0.659N P=0.221N P=0.653N P=0.236N |
|LOGISTIC REGRESSION| P=0.185N P=0.649N P=0.226N P=0.648N P=0.237N |
|COCH-ARM / FISHERS | P=0.185N P=0.691N P=0.247N P=0.691N P=0.247N |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 1/50 (2%) 2/50 (4%) 2/50 (4%) 0/50 (0%) 1/48 (2%) |
|POLY-3 ADJUSTED (b)| 2.3% 4.2% 4.4% 0.0% 2.1% |
|TERMINAL (d) | 0/23 (0%) 0/40 (0%) 2/35 (6%) 0/37 (0%) 0/40 (0%) |
|FIRST INCIDENCE | 605 592 730 (T) --- 718 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.321N P=0.533 P=0.594 P=0.487N P=0.698N |
|POLY 3 | P=0.375N P=0.528 P=0.512 P=0.484N P=0.743N |
|POLY 1.5 | P=0.387N P=0.515 P=0.503 P=0.492N P=0.755N |
|POLY 6 | P=0.356N P=0.552 P=0.530 P=0.472N P=0.721N |
|LOGISTIC REGRESSION| P=0.450N P=0.423 P=0.500 P=0.653N P=0.633 |
|COCH-ARM / FISHERS | P=0.402N P=0.500 P=0.500 P=0.500N P=0.742 |
|=================================================================================================================================|
Date: 02/25/99 EXPERIMENT: 88036 TEST: 03 Page 19
Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - ANTHRAQUINONE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Mammary Gland |
| Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/22 (0%) 0/23 (0%) 0/22 (0%) 0/26 (0%) 0/22 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Mammary Gland |
| Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 2/50 (4%) 0/50 (0%) 0/50 (0%) 1/50 (2%) 0/50 (0%) |
|POLY-3 ADJUSTED (b)| 4.7% 0.0% 0.0% 2.1% 0.0% |
|TERMINAL (d) | 2/23 (9%) 0/40 (0%) 0/35 (0%) 1/37 (3%) 0/40 (0%) |
|FIRST INCIDENCE | 730 (T) --- --- 730 (T) --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.209N P=0.127N P=0.151N P=0.336N P=0.127N |
|POLY 3 | P=0.267N P=0.220N P=0.227N P=0.469N P=0.213N |
|POLY 1.5 | P=0.264N P=0.229N P=0.234N P=0.483N P=0.225N |
|POLY 6 | P=0.273N P=0.206N P=0.215N P=0.445N P=0.195N |
|LOGISTIC REGRESSION| P=0.209N (e) (e) P=0.336N (e) |
|COCH-ARM / FISHERS | P=0.264N P=0.247N P=0.247N P=0.500N P=0.247N |
|=================================================================================================================================|
Date: 02/25/99 EXPERIMENT: 88036 TEST: 03 Page 20
Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - ANTHRAQUINONE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/22 (0%) 0/23 (0%) 0/22 (0%) 0/26 (0%) 0/22 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) 1/50 (2%) 2/50 (4%) 3/50 (6%) |
|POLY-3 ADJUSTED (b)| 2.3% 0.0% 2.2% 4.2% 6.2% |
|TERMINAL (d) | 0/23 (0%) 0/40 (0%) 1/35 (3%) 1/37 (3%) 1/40 (3%) |
|FIRST INCIDENCE | 571 --- 730 (T) 638 712 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.108 P=0.500N P=0.720N P=0.565 P=0.449 |
|POLY 3 | P=0.079 P=0.487N P=0.753N P=0.529 P=0.343 |
|POLY 1.5 | P=0.074 P=0.493N P=0.759N P=0.516 P=0.325 |
|POLY 6 | P=0.087 P=0.475N P=0.742N P=0.552 P=0.375 |
|LOGISTIC REGRESSION| P=0.057 P=0.483N P=0.753N P=0.327 P=0.238 |
|COCH-ARM / FISHERS | P=0.068 P=0.500N P=0.753N P=0.500 P=0.309 |
|=================================================================================================================================|
Date: 02/25/99 EXPERIMENT: 88036 TEST: 03 Page 21
Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - ANTHRAQUINONE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma or Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/22 (0%) 0/23 (0%) 0/22 (0%) 0/26 (0%) 0/22 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma or Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 3/50 (6%) 0/50 (0%) 1/50 (2%) 3/50 (6%) 3/50 (6%) |
|POLY-3 ADJUSTED (b)| 6.9% 0.0% 2.2% 6.3% 6.2% |
|TERMINAL (d) | 2/23 (9%) 0/40 (0%) 1/35 (3%) 2/37 (5%) 1/40 (3%) |
|FIRST INCIDENCE | 571 --- 730 (T) 638 712 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.354 P=0.065N P=0.205N P=0.504N P=0.451N |
|POLY 3 | P=0.272 P=0.107N P=0.293N P=0.623N P=0.614N |
|POLY 1.5 | P=0.263 P=0.113N P=0.303N P=0.641N P=0.637N |
|POLY 6 | P=0.287 P=0.098N P=0.275N P=0.592N P=0.573N |
|LOGISTIC REGRESSION| P=0.241 P=0.140N P=0.305N P=0.603 P=0.639 |
|COCH-ARM / FISHERS | P=0.250 P=0.121N P=0.309N P=0.661N P=0.661N |
|=================================================================================================================================|
Date: 02/25/99 EXPERIMENT: 88036 TEST: 03 Page 22
Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - ANTHRAQUINONE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroadenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 1/50 (2%) 5/50 (10%) 1/50 (2%) 8/50 (16%) 4/50 (8%) |
|POLY-3 ADJUSTED (b)| 2.5% 11.3% 2.3% 17.9% 9.8% |
|TERMINAL (d) | 1/22 (5%) 3/23 (13%) 1/22 (5%) 2/26 (8%) 3/22 (14%) |
|FIRST INCIDENCE | 729 (T) 477 729 (T) 653 677 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.160 P=0.117 P=0.763 P=0.044 * P=0.184 |
|POLY 3 | P=0.143 P=0.122 P=0.750N P=0.022 * P=0.178 |
|POLY 1.5 | P=0.144 P=0.113 P=0.756N P=0.019 * P=0.176 |
|POLY 6 | P=0.142 P=0.133 P=0.743N P=0.029 * P=0.182 |
|LOGISTIC REGRESSION| P=0.148 P=0.104 P=0.763 P=0.023 * P=0.179 |
|COCH-ARM / FISHERS | P=0.161 P=0.102 P=0.753N P=0.015 * P=0.181 |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroadenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 25/50 (50%) 26/50 (52%) 26/50 (52%) 24/50 (48%) 19/50 (38%) |
|POLY-3 ADJUSTED (b)| 54.1% 53.9% 55.6% 49.7% 38.8% |
|TERMINAL (d) | 11/23 (48%) 21/40 (53%) 18/35 (51%) 16/37 (43%) 14/40 (35%) |
|FIRST INCIDENCE | 571 575 571 611 536 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.007N** P=0.073N P=0.162N P=0.063N P=0.005N** |
|POLY 3 | P=0.040N* P=0.575N P=0.528 P=0.411N P=0.095N |
|POLY 1.5 | P=0.054N P=0.548 P=0.495 P=0.452N P=0.121N |
|POLY 6 | P=0.026N* P=0.510N P=0.582N P=0.349N P=0.063N |
|LOGISTIC REGRESSION| P=0.056N P=0.541 P=0.528 P=0.437N P=0.155N |
|COCH-ARM / FISHERS | P=0.077N P=0.500 P=0.500 P=0.500N P=0.157N |
|=================================================================================================================================|
Date: 02/25/99 EXPERIMENT: 88036 TEST: 03 Page 23
Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - ANTHRAQUINONE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma or Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 1/50 (2%) 5/50 (10%) 1/50 (2%) 8/50 (16%) 4/50 (8%) |
|POLY-3 ADJUSTED (b)| 2.5% 11.3% 2.3% 17.9% 9.8% |
|TERMINAL (d) | 1/22 (5%) 3/23 (13%) 1/22 (5%) 2/26 (8%) 3/22 (14%) |
|FIRST INCIDENCE | 729 (T) 477 729 (T) 653 677 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.160 P=0.117 P=0.763 P=0.044 * P=0.184 |
|POLY 3 | P=0.143 P=0.122 P=0.750N P=0.022 * P=0.178 |
|POLY 1.5 | P=0.144 P=0.113 P=0.756N P=0.019 * P=0.176 |
|POLY 6 | P=0.142 P=0.133 P=0.743N P=0.029 * P=0.182 |
|LOGISTIC REGRESSION| P=0.148 P=0.104 P=0.763 P=0.023 * P=0.179 |
|COCH-ARM / FISHERS | P=0.161 P=0.102 P=0.753N P=0.015 * P=0.181 |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma or Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 25/50 (50%) 26/50 (52%) 26/50 (52%) 25/50 (50%) 19/50 (38%) |
|POLY-3 ADJUSTED (b)| 54.1% 53.9% 55.6% 51.8% 38.8% |
|TERMINAL (d) | 11/23 (48%) 21/40 (53%) 18/35 (51%) 17/37 (46%) 14/40 (35%) |
|FIRST INCIDENCE | 571 575 571 611 536 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.007N** P=0.073N P=0.162N P=0.081N P=0.005N** |
|POLY 3 | P=0.044N* P=0.575N P=0.528 P=0.491N P=0.095N |
|POLY 1.5 | P=0.059N P=0.548 P=0.495 P=0.532N P=0.121N |
|POLY 6 | P=0.028N* P=0.510N P=0.582N P=0.427N P=0.063N |
|LOGISTIC REGRESSION| P=0.060N P=0.541 P=0.528 P=0.507N P=0.155N |
|COCH-ARM / FISHERS | P=0.083N P=0.500 P=0.500 P=0.579N P=0.157N |
|=================================================================================================================================|
Date: 02/25/99 EXPERIMENT: 88036 TEST: 03 Page 24
Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - ANTHRAQUINONE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma, Carcinoma, or Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 1/50 (2%) 5/50 (10%) 1/50 (2%) 8/50 (16%) 4/50 (8%) |
|POLY-3 ADJUSTED (b)| 2.5% 11.3% 2.3% 17.9% 9.8% |
|TERMINAL (d) | 1/22 (5%) 3/23 (13%) 1/22 (5%) 2/26 (8%) 3/22 (14%) |
|FIRST INCIDENCE | 729 (T) 477 729 (T) 653 677 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.160 P=0.117 P=0.763 P=0.044 * P=0.184 |
|POLY 3 | P=0.143 P=0.122 P=0.750N P=0.022 * P=0.178 |
|POLY 1.5 | P=0.144 P=0.113 P=0.756N P=0.019 * P=0.176 |
|POLY 6 | P=0.142 P=0.133 P=0.743N P=0.029 * P=0.182 |
|LOGISTIC REGRESSION| P=0.148 P=0.104 P=0.763 P=0.023 * P=0.179 |
|COCH-ARM / FISHERS | P=0.161 P=0.102 P=0.753N P=0.015 * P=0.181 |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma, Carcinoma, or Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 26/50 (52%) 26/50 (52%) 26/50 (52%) 27/50 (54%) 21/50 (42%) |
|POLY-3 ADJUSTED (b)| 55.6% 53.9% 55.6% 55.5% 42.8% |
|TERMINAL (d) | 11/23 (48%) 21/40 (53%) 18/35 (51%) 18/37 (49%) 15/40 (38%) |
|FIRST INCIDENCE | 571 575 571 611 536 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.017N* P=0.055N P=0.128N P=0.107N P=0.008N** |
|POLY 3 | P=0.102N P=0.515N P=0.580N P=0.578N P=0.144N |
|POLY 1.5 | P=0.126N P=0.546N P=0.563 P=0.546 P=0.174N |
|POLY 6 | P=0.072N P=0.460N P=0.534N P=0.515N P=0.103N |
|LOGISTIC REGRESSION| P=0.136N P=0.577N P=0.565N P=0.504 P=0.247N |
|COCH-ARM / FISHERS | P=0.163N P=0.579N P=0.579N P=0.500 P=0.212N |
|=================================================================================================================================|
Date: 02/25/99 EXPERIMENT: 88036 TEST: 03 Page 25
Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - ANTHRAQUINONE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 15/50 (30%) 15/50 (30%) 11/49 (22%) 11/50 (22%) 9/50 (18%) |
|POLY-3 ADJUSTED (b)| 34.0% 32.0% 25.6% 24.3% 21.8% |
|TERMINAL (d) | 5/22 (23%) 3/23 (13%) 6/22 (27%) 4/26 (15%) 6/22 (27%) |
|FIRST INCIDENCE | 537 481 620 537 603 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.091N P=0.453N P=0.224N P=0.149N P=0.135N |
|POLY 3 | P=0.100N P=0.509N P=0.266N P=0.216N P=0.151N |
|POLY 1.5 | P=0.090N P=0.542N P=0.269N P=0.232N P=0.142N |
|POLY 6 | P=0.117N P=0.465N P=0.262N P=0.198N P=0.168N |
|LOGISTIC REGRESSION| P=0.071N P=0.484 P=0.262N P=0.267N P=0.124N |
|COCH-ARM / FISHERS | P=0.070N P=0.586N P=0.266N P=0.247N P=0.121N |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 20/50 (40%) 22/50 (44%) 23/50 (46%) 17/49 (35%) 19/49 (39%) |
|POLY-3 ADJUSTED (b)| 44.4% 45.0% 50.1% 35.9% 39.5% |
|TERMINAL (d) | 10/23 (44%) 16/40 (40%) 16/35 (46%) 10/36 (28%) 16/40 (40%) |
|FIRST INCIDENCE | 550 513 625 550 689 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.050N P=0.156N P=0.272N P=0.055N P=0.034N* |
|POLY 3 | P=0.220N P=0.559 P=0.369 P=0.264N P=0.395N |
|POLY 1.5 | P=0.260N P=0.495 P=0.340 P=0.310N P=0.458N |
|POLY 6 | P=0.170N P=0.509N P=0.432 P=0.201N P=0.302N |
|LOGISTIC REGRESSION| P=0.256N P=0.412 P=0.442 P=0.327N P=0.323N |
|COCH-ARM / FISHERS | P=0.318N P=0.420 P=0.343 P=0.368N P=0.532N |
|=================================================================================================================================|
Date: 02/25/99 EXPERIMENT: 88036 TEST: 03 Page 26
Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - ANTHRAQUINONE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Skin |
| Basal Cell Adenoma, Basosquamous Tumor Benign, or |
| Trichoepithelioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|POLY-3 ADJUSTED (b)| 4.9% 2.3% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/22 (5%) 1/23 (4%) 0/22 (0%) 0/26 (0%) 0/22 (0%) |
|FIRST INCIDENCE | 724 729 (T) --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.103N P=0.476N P=0.240N P=0.209N P=0.244N |
|POLY 3 | P=0.106N P=0.476N P=0.227N P=0.221N P=0.237N |
|POLY 1.5 | P=0.106N P=0.486N P=0.232N P=0.229N P=0.239N |
|POLY 6 | P=0.106N P=0.462N P=0.219N P=0.210N P=0.234N |
|LOGISTIC REGRESSION| P=0.102N P=0.455N P=0.210N P=0.192N P=0.239N |
|COCH-ARM / FISHERS | P=0.106N P=0.500N P=0.247N P=0.247N P=0.247N |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Skin |
| Basal Cell Adenoma, Basosquamous Tumor Benign, or |
| Trichoepithelioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) 1/50 (2%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% 2.1% |
|TERMINAL (d) | 0/23 (0%) 0/40 (0%) 0/35 (0%) 0/37 (0%) 1/40 (3%) |
|FIRST INCIDENCE | --- --- --- --- 730 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.173 (e) (e) (e) P=0.610 |
|POLY 3 | P=0.154 (e) (e) (e) P=0.522 |
|POLY 1.5 | P=0.150 (e) (e) (e) P=0.512 |
|POLY 6 | P=0.160 (e) (e) (e) P=0.540 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) P=0.610 |
|COCH-ARM / FISHERS | P=0.145 (e) (e) (e) P=0.500 |
|=================================================================================================================================|
Date: 02/25/99 EXPERIMENT: 88036 TEST: 03 Page 27
Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - ANTHRAQUINONE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Skin |
| Basal Cell Carcinoma, Basal Cell Adenoma, Basosquamous |
| Tumor (benign, malignant or NOS), or Trichoepithelioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|POLY-3 ADJUSTED (b)| 4.9% 2.3% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/22 (5%) 1/23 (4%) 0/22 (0%) 0/26 (0%) 0/22 (0%) |
|FIRST INCIDENCE | 724 729 (T) --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.103N P=0.476N P=0.240N P=0.209N P=0.244N |
|POLY 3 | P=0.106N P=0.476N P=0.227N P=0.221N P=0.237N |
|POLY 1.5 | P=0.106N P=0.486N P=0.232N P=0.229N P=0.239N |
|POLY 6 | P=0.106N P=0.462N P=0.219N P=0.210N P=0.234N |
|LOGISTIC REGRESSION| P=0.102N P=0.455N P=0.210N P=0.192N P=0.239N |
|COCH-ARM / FISHERS | P=0.106N P=0.500N P=0.247N P=0.247N P=0.247N |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Skin |
| Basal Cell Carcinoma, Basal Cell Adenoma, Basosquamous |
| Tumor (benign, malignant or NOS), or Trichoepithelioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) 1/50 (2%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% 2.1% |
|TERMINAL (d) | 0/23 (0%) 0/40 (0%) 0/35 (0%) 0/37 (0%) 1/40 (3%) |
|FIRST INCIDENCE | --- --- --- --- 730 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.173 (e) (e) (e) P=0.610 |
|POLY 3 | P=0.154 (e) (e) (e) P=0.522 |
|POLY 1.5 | P=0.150 (e) (e) (e) P=0.512 |
|POLY 6 | P=0.160 (e) (e) (e) P=0.540 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) P=0.610 |
|COCH-ARM / FISHERS | P=0.145 (e) (e) (e) P=0.500 |
|=================================================================================================================================|
Date: 02/25/99 EXPERIMENT: 88036 TEST: 03 Page 28
Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - ANTHRAQUINONE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Skin |
| Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor |
| (M or B), Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepitheliom |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 3/50 (6%) 3/50 (6%) 3/50 (6%) 2/50 (4%) 7/50 (14%) |
|POLY-3 ADJUSTED (b)| 7.3% 6.8% 7.0% 4.6% 17.2% |
|TERMINAL (d) | 1/22 (5%) 2/23 (9%) 2/22 (9%) 1/26 (4%) 5/22 (23%) |
|FIRST INCIDENCE | 562 663 723 719 690 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.067 P=0.620N P=0.651N P=0.434N P=0.163 |
|POLY 3 | P=0.064 P=0.634N P=0.647N P=0.473N P=0.149 |
|POLY 1.5 | P=0.066 P=0.646N P=0.655N P=0.487N P=0.149 |
|POLY 6 | P=0.063 P=0.617N P=0.635N P=0.453N P=0.149 |
|LOGISTIC REGRESSION| P=0.059 P=0.651N P=0.638N P=0.482N P=0.160 |
|COCH-ARM / FISHERS | P=0.071 P=0.661N P=0.661N P=0.500N P=0.159 |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Skin |
| Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor |
| (M or B), Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepitheliom |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 0/50 (0%) 0/50 (0%) 1/50 (2%) |
|POLY-3 ADJUSTED (b)| 0.0% 2.2% 0.0% 0.0% 2.1% |
|TERMINAL (d) | 0/23 (0%) 1/40 (3%) 0/35 (0%) 0/37 (0%) 1/40 (3%) |
|FIRST INCIDENCE | --- 730 (T) --- --- 730 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.465 P=0.610 (e) (e) P=0.610 |
|POLY 3 | P=0.431 P=0.515 (e) (e) P=0.522 |
|POLY 1.5 | P=0.419 P=0.508 (e) (e) P=0.512 |
|POLY 6 | P=0.451 P=0.529 (e) (e) P=0.540 |
|LOGISTIC REGRESSION| (e) P=0.610 (e) (e) P=0.610 |
|COCH-ARM / FISHERS | P=0.404 P=0.500 (e) (e) P=0.500 |
|=================================================================================================================================|
Date: 02/25/99 EXPERIMENT: 88036 TEST: 03 Page 29
Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - ANTHRAQUINONE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Skin |
| Fibroma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 5/50 (10%) 4/50 (8%) 1/50 (2%) 5/50 (10%) 2/50 (4%) |
|POLY-3 ADJUSTED (b)| 12.2% 9.1% 2.3% 11.1% 4.9% |
|TERMINAL (d) | 3/22 (14%) 2/23 (9%) 1/22 (5%) 2/26 (8%) 0/22 (0%) |
|FIRST INCIDENCE | 677 668 729 (T) 249 680 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.257N P=0.451N P=0.099N P=0.519N P=0.211N |
|POLY 3 | P=0.272N P=0.455N P=0.091N P=0.571N P=0.214N |
|POLY 1.5 | P=0.271N P=0.475N P=0.096N P=0.596N P=0.219N |
|POLY 6 | P=0.272N P=0.429N P=0.083N P=0.535N P=0.205N |
|LOGISTIC REGRESSION| P=0.262N P=0.415N P=0.075N P=0.614 P=0.210N |
|COCH-ARM / FISHERS | P=0.260N P=0.500N P=0.102N P=0.630N P=0.218N |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Skin |
| Fibroma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 1/50 (2%) 0/50 (0%) 0/50 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 2.2% 0.0% 0.0% |
|TERMINAL (d) | 0/23 (0%) 0/40 (0%) 0/35 (0%) 0/37 (0%) 0/40 (0%) |
|FIRST INCIDENCE | --- --- 703 --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.607N (e) P=0.557 (e) (e) |
|POLY 3 | P=0.640N (e) P=0.509 (e) (e) |
|POLY 1.5 | P=0.645N (e) P=0.503 (e) (e) |
|POLY 6 | P=0.632N (e) P=0.521 (e) (e) |
|LOGISTIC REGRESSION| P=0.652N (e) P=0.505 (e) (e) |
|COCH-ARM / FISHERS | P=0.649N (e) P=0.500 (e) (e) |
|=================================================================================================================================|
Date: 02/25/99 EXPERIMENT: 88036 TEST: 03 Page 30
Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - ANTHRAQUINONE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Skin |
| Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, |
| or Fibrous Histiocytoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 5/50 (10%) 4/50 (8%) 2/50 (4%) 5/50 (10%) 3/50 (6%) |
|POLY-3 ADJUSTED (b)| 12.2% 9.1% 4.7% 11.1% 7.3% |
|TERMINAL (d) | 3/22 (14%) 2/23 (9%) 1/22 (5%) 2/26 (8%) 0/22 (0%) |
|FIRST INCIDENCE | 677 668 705 249 680 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.399N P=0.451N P=0.202N P=0.519N P=0.349N |
|POLY 3 | P=0.407N P=0.455N P=0.197N P=0.571N P=0.353N |
|POLY 1.5 | P=0.407N P=0.475N P=0.207N P=0.596N P=0.360N |
|POLY 6 | P=0.406N P=0.429N P=0.183N P=0.535N P=0.341N |
|LOGISTIC REGRESSION| P=0.400N P=0.415N P=0.169N P=0.614 P=0.349N |
|COCH-ARM / FISHERS | P=0.394N P=0.500N P=0.218N P=0.630N P=0.357N |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Skin |
| Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, |
| or Fibrous Histiocytoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 1/50 (2%) 0/50 (0%) 0/50 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 2.2% 0.0% 0.0% |
|TERMINAL (d) | 0/23 (0%) 0/40 (0%) 0/35 (0%) 0/37 (0%) 0/40 (0%) |
|FIRST INCIDENCE | --- --- 703 --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.607N (e) P=0.557 (e) (e) |
|POLY 3 | P=0.640N (e) P=0.509 (e) (e) |
|POLY 1.5 | P=0.645N (e) P=0.503 (e) (e) |
|POLY 6 | P=0.632N (e) P=0.521 (e) (e) |
|LOGISTIC REGRESSION| P=0.652N (e) P=0.505 (e) (e) |
|COCH-ARM / FISHERS | P=0.649N (e) P=0.500 (e) (e) |
|=================================================================================================================================|
Date: 02/25/99 EXPERIMENT: 88036 TEST: 03 Page 31
Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - ANTHRAQUINONE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Skin |
| Keratoacanthoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 3/50 (6%) 2/50 (4%) 5/50 (10%) |
|POLY-3 ADJUSTED (b)| 0.0% 4.6% 7.0% 4.6% 12.3% |
|TERMINAL (d) | 0/22 (0%) 1/23 (4%) 2/22 (9%) 1/26 (4%) 4/22 (18%) |
|FIRST INCIDENCE | --- 663 723 719 724 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.026 * P=0.268 P=0.127 P=0.284 P=0.032 * |
|POLY 3 | P=0.027 * P=0.254 P=0.127 P=0.253 P=0.029 * |
|POLY 1.5 | P=0.027 * P=0.247 P=0.123 P=0.245 P=0.029 * |
|POLY 6 | P=0.027 * P=0.265 P=0.133 P=0.266 P=0.030 * |
|LOGISTIC REGRESSION| P=0.021 * P=0.249 P=0.137 P=0.282 P=0.028 * |
|COCH-ARM / FISHERS | P=0.029 * P=0.247 P=0.121 P=0.247 P=0.028 * |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Skin |
| Keratoacanthoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 2.2% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/23 (0%) 1/40 (3%) 0/35 (0%) 0/37 (0%) 0/40 (0%) |
|FIRST INCIDENCE | --- 730 (T) --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.455N P=0.610 (e) (e) (e) |
|POLY 3 | P=0.483N P=0.515 (e) (e) (e) |
|POLY 1.5 | P=0.490N P=0.508 (e) (e) (e) |
|POLY 6 | P=0.473N P=0.529 (e) (e) (e) |
|LOGISTIC REGRESSION| (e) P=0.610 (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.497N P=0.500 (e) (e) (e) |
|=================================================================================================================================|
Date: 02/25/99 EXPERIMENT: 88036 TEST: 03 Page 32
Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - ANTHRAQUINONE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Skin |
| Melanoma Malignant |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 3/50 (6%) 0/50 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 6.8% 0.0% |
|TERMINAL (d) | 0/22 (0%) 0/23 (0%) 0/22 (0%) 2/26 (8%) 0/22 (0%) |
|FIRST INCIDENCE | --- --- --- 593 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.426 (e) (e) P=0.150 (e) |
|POLY 3 | P=0.387 (e) (e) P=0.134 (e) |
|POLY 1.5 | P=0.396 (e) (e) P=0.126 (e) |
|POLY 6 | P=0.373 (e) (e) P=0.145 (e) |
|LOGISTIC REGRESSION| P=0.421 (e) (e) P=0.120 (e) |
|COCH-ARM / FISHERS | P=0.423 (e) (e) P=0.121 (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Skin |
| Melanoma Malignant |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/23 (0%) 0/40 (0%) 0/35 (0%) 0/37 (0%) 0/40 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 02/25/99 EXPERIMENT: 88036 TEST: 03 Page 33
Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - ANTHRAQUINONE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Papilloma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) 0/50 (0%) 0/50 (0%) 2/50 (4%) |
|POLY-3 ADJUSTED (b)| 2.4% 0.0% 0.0% 0.0% 4.9% |
|TERMINAL (d) | 0/22 (0%) 0/23 (0%) 0/22 (0%) 0/26 (0%) 1/22 (5%) |
|FIRST INCIDENCE | 562 --- --- --- 690 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.153 P=0.487N P=0.491N P=0.487N P=0.512 |
|POLY 3 | P=0.149 P=0.489N P=0.493N P=0.488N P=0.496 |
|POLY 1.5 | P=0.150 P=0.494N P=0.497N P=0.494N P=0.494 |
|POLY 6 | P=0.146 P=0.482N P=0.488N P=0.480N P=0.499 |
|LOGISTIC REGRESSION| P=0.165 P=0.566N P=0.461N P=0.467N P=0.504 |
|COCH-ARM / FISHERS | P=0.155 P=0.500N P=0.500N P=0.500N P=0.500 |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Papilloma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/23 (0%) 0/40 (0%) 0/35 (0%) 0/37 (0%) 0/40 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 02/25/99 EXPERIMENT: 88036 TEST: 03 Page 34
Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - ANTHRAQUINONE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Papilloma, Papilloma, Squamous Cell |
| Carcinoma or Keratoacanthoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 1/50 (2%) 2/50 (4%) 3/50 (6%) 2/50 (4%) 7/50 (14%) |
|POLY-3 ADJUSTED (b)| 2.4% 4.6% 7.0% 4.6% 17.2% |
|TERMINAL (d) | 0/22 (0%) 1/23 (4%) 2/22 (9%) 1/26 (4%) 5/22 (23%) |
|FIRST INCIDENCE | 562 663 723 719 690 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.008 ** P=0.537 P=0.318 P=0.552 P=0.035 * |
|POLY 3 | P=0.008 ** P=0.522 P=0.317 P=0.521 P=0.027 * |
|POLY 1.5 | P=0.008 ** P=0.512 P=0.311 P=0.510 P=0.028 * |
|POLY 6 | P=0.007 ** P=0.535 P=0.327 P=0.536 P=0.027 * |
|LOGISTIC REGRESSION| P=0.007 ** P=0.453 P=0.310 P=0.491 P=0.032 * |
|COCH-ARM / FISHERS | P=0.009 ** P=0.500 P=0.309 P=0.500 P=0.030 * |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Papilloma, Papilloma, Squamous Cell |
| Carcinoma or Keratoacanthoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 2.2% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/23 (0%) 1/40 (3%) 0/35 (0%) 0/37 (0%) 0/40 (0%) |
|FIRST INCIDENCE | --- 730 (T) --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.455N P=0.610 (e) (e) (e) |
|POLY 3 | P=0.483N P=0.515 (e) (e) (e) |
|POLY 1.5 | P=0.490N P=0.508 (e) (e) (e) |
|POLY 6 | P=0.473N P=0.529 (e) (e) (e) |
|LOGISTIC REGRESSION| (e) P=0.610 (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.497N P=0.500 (e) (e) (e) |
|=================================================================================================================================|
Date: 02/25/99 EXPERIMENT: 88036 TEST: 03 Page 35
Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - ANTHRAQUINONE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Papilloma, Papilloma, or Keratoacanthoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 1/50 (2%) 2/50 (4%) 3/50 (6%) 2/50 (4%) 7/50 (14%) |
|POLY-3 ADJUSTED (b)| 2.4% 4.6% 7.0% 4.6% 17.2% |
|TERMINAL (d) | 0/22 (0%) 1/23 (4%) 2/22 (9%) 1/26 (4%) 5/22 (23%) |
|FIRST INCIDENCE | 562 663 723 719 690 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.008 ** P=0.537 P=0.318 P=0.552 P=0.035 * |
|POLY 3 | P=0.008 ** P=0.522 P=0.317 P=0.521 P=0.027 * |
|POLY 1.5 | P=0.008 ** P=0.512 P=0.311 P=0.510 P=0.028 * |
|POLY 6 | P=0.007 ** P=0.535 P=0.327 P=0.536 P=0.027 * |
|LOGISTIC REGRESSION| P=0.007 ** P=0.453 P=0.310 P=0.491 P=0.032 * |
|COCH-ARM / FISHERS | P=0.009 ** P=0.500 P=0.309 P=0.500 P=0.030 * |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Papilloma, Papilloma, or Keratoacanthoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 2.2% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/23 (0%) 1/40 (3%) 0/35 (0%) 0/37 (0%) 0/40 (0%) |
|FIRST INCIDENCE | --- 730 (T) --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.455N P=0.610 (e) (e) (e) |
|POLY 3 | P=0.483N P=0.515 (e) (e) (e) |
|POLY 1.5 | P=0.490N P=0.508 (e) (e) (e) |
|POLY 6 | P=0.473N P=0.529 (e) (e) (e) |
|LOGISTIC REGRESSION| (e) P=0.610 (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.497N P=0.500 (e) (e) (e) |
|=================================================================================================================================|
Date: 02/25/99 EXPERIMENT: 88036 TEST: 03 Page 36
Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - ANTHRAQUINONE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Testes |
| Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 46/50 (92%) 46/50 (92%) 47/50 (94%) 47/50 (94%) 48/50 (96%) |
|POLY-3 ADJUSTED (b)| 95.8% 94.8% 98.0% 97.0% 98.2% |
|TERMINAL (d) | 22/22 (100%) 23/23 (100%) 22/22 (100%) 25/26 (96%) 22/22 (100%) |
|FIRST INCIDENCE | 485 477 561 583 421 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.381 P=0.323N P=0.469N P=0.195N P=0.480 |
|POLY 3 | P=0.248 P=0.627N P=0.483 P=0.605 P=0.450 |
|POLY 1.5 | P=0.162 P=0.637N P=0.448 P=0.500 P=0.303 |
|POLY 6 | P=0.471 P=0.618N P=0.699 P=0.788N P=0.749 |
|LOGISTIC REGRESSION| P=0.068 P=0.431N P=0.623 P=0.672N P=0.174 |
|COCH-ARM / FISHERS | P=0.231 P=0.643N P=0.500 P=0.500 P=0.339 |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Testes |
| Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | |
|POLY-3 ADJUSTED (b)| |
|TERMINAL (d) | |
|FIRST INCIDENCE | |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | |
|POLY 3 | |
|POLY 1.5 | |
|POLY 6 | |
|LOGISTIC REGRESSION| |
|COCH-ARM / FISHERS | |
|=================================================================================================================================|
Date: 02/25/99 EXPERIMENT: 88036 TEST: 03 Page 37
Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - ANTHRAQUINONE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 2/50 (4%) 6/50 (12%) 6/48 (13%) 7/50 (14%) 4/47 (9%) |
|POLY-3 ADJUSTED (b)| 4.9% 13.6% 14.2% 16.0% 10.4% |
|TERMINAL (d) | 1/22 (5%) 3/23 (13%) 1/22 (5%) 5/26 (19%) 4/22 (18%) |
|FIRST INCIDENCE | 687 674 561 690 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.475 P=0.170 P=0.175 P=0.139 P=0.338 |
|POLY 3 | P=0.403 P=0.159 P=0.143 P=0.095 P=0.307 |
|POLY 1.5 | P=0.404 P=0.147 P=0.131 P=0.087 P=0.303 |
|POLY 6 | P=0.403 P=0.176 P=0.162 P=0.108 P=0.313 |
|LOGISTIC REGRESSION| P=0.414 P=0.164 P=0.120 P=0.127 P=0.325 |
|COCH-ARM / FISHERS | P=0.427 P=0.134 P=0.121 P=0.080 P=0.310 |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 5/50 (10%) 4/50 (8%) 5/50 (10%) 10/50 (20%) 9/49 (18%) |
|POLY-3 ADJUSTED (b)| 11.5% 8.6% 11.0% 21.2% 18.8% |
|TERMINAL (d) | 4/23 (17%) 4/40 (10%) 3/35 (9%) 8/37 (22%) 9/40 (23%) |
|FIRST INCIDENCE | 550 730 (T) 638 689 730 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.157 P=0.218N P=0.409N P=0.400 P=0.559 |
|POLY 3 | P=0.068 P=0.460N P=0.606N P=0.168 P=0.248 |
|POLY 1.5 | P=0.057 P=0.480N P=0.624N P=0.150 P=0.216 |
|POLY 6 | P=0.088 P=0.423N P=0.569N P=0.204 P=0.305 |
|LOGISTIC REGRESSION| P=0.087 P=0.447N P=0.620N P=0.191 P=0.290 |
|COCH-ARM / FISHERS | P=0.045 * P=0.500N P=0.630N P=0.131 P=0.183 |
|=================================================================================================================================|
Date: 02/25/99 EXPERIMENT: 88036 TEST: 03 Page 38
Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - ANTHRAQUINONE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 0/48 (0%) 0/50 (0%) 0/47 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 4.6% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/22 (0%) 2/23 (9%) 0/22 (0%) 0/26 (0%) 0/22 (0%) |
|FIRST INCIDENCE | --- 729 (T) --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.298N P=0.247 (e) (e) (e) |
|POLY 3 | P=0.292N P=0.253 (e) (e) (e) |
|POLY 1.5 | P=0.300N P=0.246 (e) (e) (e) |
|POLY 6 | P=0.280N P=0.262 (e) (e) (e) |
|LOGISTIC REGRESSION| (e) P=0.247 (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.312N P=0.247 (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) 1/49 (2%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% 2.1% |
|TERMINAL (d) | 0/23 (0%) 0/40 (0%) 0/35 (0%) 0/37 (0%) 1/40 (3%) |
|FIRST INCIDENCE | --- --- --- --- 730 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.173 (e) (e) (e) P=0.610 |
|POLY 3 | P=0.152 (e) (e) (e) P=0.521 |
|POLY 1.5 | P=0.148 (e) (e) (e) P=0.509 |
|POLY 6 | P=0.159 (e) (e) (e) P=0.539 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) P=0.610 |
|COCH-ARM / FISHERS | P=0.142 (e) (e) (e) P=0.495 |
|=================================================================================================================================|
Date: 02/25/99 EXPERIMENT: 88036 TEST: 03 Page 39
Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - ANTHRAQUINONE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma or Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 2/50 (4%) 7/50 (14%) 6/48 (13%) 7/50 (14%) 4/47 (9%) |
|POLY-3 ADJUSTED (b)| 4.9% 15.8% 14.2% 16.0% 10.4% |
|TERMINAL (d) | 1/22 (5%) 4/23 (17%) 1/22 (5%) 5/26 (19%) 4/22 (18%) |
|FIRST INCIDENCE | 687 674 561 690 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.536 P=0.107 P=0.175 P=0.139 P=0.338 |
|POLY 3 | P=0.465 P=0.098 P=0.143 P=0.095 P=0.307 |
|POLY 1.5 | P=0.464 P=0.089 P=0.131 P=0.087 P=0.303 |
|POLY 6 | P=0.466 P=0.111 P=0.162 P=0.108 P=0.313 |
|LOGISTIC REGRESSION| P=0.474 P=0.106 P=0.120 P=0.127 P=0.325 |
|COCH-ARM / FISHERS | P=0.486 P=0.080 P=0.121 P=0.080 P=0.310 |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma or Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 5/50 (10%) 4/50 (8%) 5/50 (10%) 10/50 (20%) 10/49 (20%) |
|POLY-3 ADJUSTED (b)| 11.5% 8.6% 11.0% 21.2% 20.9% |
|TERMINAL (d) | 4/23 (17%) 4/40 (10%) 3/35 (9%) 8/37 (22%) 10/40 (25%) |
|FIRST INCIDENCE | 550 730 (T) 638 689 730 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.097 P=0.218N P=0.409N P=0.400 P=0.471 |
|POLY 3 | P=0.036 * P=0.460N P=0.606N P=0.168 P=0.175 |
|POLY 1.5 | P=0.029 * P=0.480N P=0.624N P=0.150 P=0.148 |
|POLY 6 | P=0.047 * P=0.423N P=0.569N P=0.204 P=0.225 |
|LOGISTIC REGRESSION| P=0.049 * P=0.447N P=0.620N P=0.191 P=0.220 |
|COCH-ARM / FISHERS | P=0.023 * P=0.500N P=0.630N P=0.131 P=0.122 |
|=================================================================================================================================|
Date: 02/25/99 EXPERIMENT: 88036 TEST: 03 Page 40
Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - ANTHRAQUINONE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) 4/48 (8%) 1/50 (2%) 1/47 (2%) |
|POLY-3 ADJUSTED (b)| 2.4% 0.0% 9.7% 2.3% 2.6% |
|TERMINAL (d) | 0/22 (0%) 0/23 (0%) 2/22 (9%) 1/26 (4%) 1/22 (5%) |
|FIRST INCIDENCE | 674 --- 704 729 (T) 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.576N P=0.471N P=0.214 P=0.719N P=0.754N |
|POLY 3 | P=0.597N P=0.487N P=0.179 P=0.746N P=0.747 |
|POLY 1.5 | P=0.598N P=0.493N P=0.172 P=0.753N P=0.744 |
|POLY 6 | P=0.594N P=0.480N P=0.190 P=0.735N P=0.751 |
|LOGISTIC REGRESSION| P=0.593N P=0.508N P=0.195 P=0.746N P=0.753 |
|COCH-ARM / FISHERS | P=0.588N P=0.500N P=0.168 P=0.753N P=0.737 |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) 0/50 (0%) 0/50 (0%) 1/49 (2%) |
|POLY-3 ADJUSTED (b)| 2.3% 0.0% 0.0% 0.0% 2.1% |
|TERMINAL (d) | 1/23 (4%) 0/40 (0%) 0/35 (0%) 0/37 (0%) 1/40 (3%) |
|FIRST INCIDENCE | 730 (T) --- --- --- 730 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.564 P=0.390N P=0.416N P=0.405N P=0.633N |
|POLY 3 | P=0.505 P=0.485N P=0.491N P=0.482N P=0.736N |
|POLY 1.5 | P=0.504 P=0.492N P=0.497N P=0.491N P=0.750N |
|POLY 6 | P=0.504 P=0.471N P=0.479N P=0.469N P=0.714N |
|LOGISTIC REGRESSION| P=0.564 (e) (e) (e) P=0.633N |
|COCH-ARM / FISHERS | P=0.500 P=0.500N P=0.500N P=0.500N P=0.747 |
|=================================================================================================================================|
Date: 02/25/99 EXPERIMENT: 88036 TEST: 03 Page 41
Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - ANTHRAQUINONE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 1/50 (2%) 3/50 (6%) 0/48 (0%) 1/50 (2%) 0/47 (0%) |
|POLY-3 ADJUSTED (b)| 2.4% 6.8% 0.0% 2.3% 0.0% |
|TERMINAL (d) | 0/22 (0%) 0/23 (0%) 0/22 (0%) 0/26 (0%) 0/22 (0%) |
|FIRST INCIDENCE | 562 477 --- 690 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.167N P=0.339 P=0.491N P=0.718N P=0.500N |
|POLY 3 | P=0.168N P=0.332 P=0.501N P=0.747N P=0.515N |
|POLY 1.5 | P=0.172N P=0.321 P=0.505N P=0.754N P=0.516N |
|POLY 6 | P=0.164N P=0.347 P=0.495N P=0.737N P=0.512N |
|LOGISTIC REGRESSION| P=0.140N P=0.216 P=0.468N P=0.762 P=0.456N |
|COCH-ARM / FISHERS | P=0.173N P=0.309 P=0.510N P=0.753N P=0.515N |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 1/50 (2%) 0/50 (0%) 0/49 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 2.2% 0.0% 0.0% |
|TERMINAL (d) | 0/23 (0%) 0/40 (0%) 1/35 (3%) 0/37 (0%) 0/40 (0%) |
|FIRST INCIDENCE | --- --- 730 (T) --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.607N (e) P=0.584 (e) (e) |
|POLY 3 | P=0.643N (e) P=0.509 (e) (e) |
|POLY 1.5 | P=0.648N (e) P=0.503 (e) (e) |
|POLY 6 | P=0.635N (e) P=0.520 (e) (e) |
|LOGISTIC REGRESSION| (e) (e) P=0.584 (e) (e) |
|COCH-ARM / FISHERS | P=0.652N (e) P=0.500 (e) (e) |
|=================================================================================================================================|
Date: 02/25/99 EXPERIMENT: 88036 TEST: 03 Page 42
Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - ANTHRAQUINONE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma or Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 2/50 (4%) 3/50 (6%) 4/48 (8%) 2/50 (4%) 1/47 (2%) |
|POLY-3 ADJUSTED (b)| 4.8% 6.8% 9.7% 4.6% 2.6% |
|TERMINAL (d) | 0/22 (0%) 0/23 (0%) 2/22 (9%) 1/26 (4%) 1/22 (5%) |
|FIRST INCIDENCE | 562 477 704 690 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.244N P=0.543 P=0.381 P=0.624N P=0.493N |
|POLY 3 | P=0.267N P=0.532 P=0.333 P=0.674N P=0.527N |
|POLY 1.5 | P=0.267N P=0.518 P=0.325 P=0.684N P=0.528N |
|POLY 6 | P=0.264N P=0.548 P=0.345 P=0.659N P=0.525N |
|LOGISTIC REGRESSION| P=0.256N P=0.403 P=0.325 P=0.684 P=0.515N |
|COCH-ARM / FISHERS | P=0.256N P=0.500 P=0.319 P=0.691N P=0.523N |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma or Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) 1/50 (2%) 0/50 (0%) 1/49 (2%) |
|POLY-3 ADJUSTED (b)| 2.3% 0.0% 2.2% 0.0% 2.1% |
|TERMINAL (d) | 1/23 (4%) 0/40 (0%) 1/35 (3%) 0/37 (0%) 1/40 (3%) |
|FIRST INCIDENCE | 730 (T) --- 730 (T) --- 730 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.649 P=0.390N P=0.665N P=0.405N P=0.633N |
|POLY 3 | P=0.590 P=0.485N P=0.751N P=0.482N P=0.736N |
|POLY 1.5 | P=0.583 P=0.492N P=0.758N P=0.491N P=0.750N |
|POLY 6 | P=0.599 P=0.471N P=0.738N P=0.469N P=0.714N |
|LOGISTIC REGRESSION| P=0.649 (e) P=0.665N (e) P=0.633N |
|COCH-ARM / FISHERS | P=0.574 P=0.500N P=0.753N P=0.500N P=0.747 |
|=================================================================================================================================|
Date: 02/25/99 EXPERIMENT: 88036 TEST: 03 Page 43
Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - ANTHRAQUINONE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Urinary Bladder |
| Carcinoma or Papilloma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 3/50 (6%) 7/50 (14%) 3/49 (6%) |
|POLY-3 ADJUSTED (b)| 0.0% 2.3% 7.0% 15.5% 7.6% |
|TERMINAL (d) | 0/22 (0%) 1/23 (4%) 3/22 (14%) 3/26 (12%) 3/22 (14%) |
|FIRST INCIDENCE | --- 729 (T) 729 (T) 537 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.069 P=0.509 P=0.118 P=0.017 * P=0.118 |
|POLY 3 | P=0.053 P=0.514 P=0.127 P=0.011 * P=0.113 |
|POLY 1.5 | P=0.055 P=0.508 P=0.123 P=0.009 ** P=0.113 |
|POLY 6 | P=0.050 P=0.522 P=0.133 P=0.014 * P=0.115 |
|LOGISTIC REGRESSION| P=0.060 P=0.509 P=0.118 P=0.008 ** P=0.118 |
|COCH-ARM / FISHERS | P=0.067 P=0.500 P=0.121 P=0.006 ** P=0.117 |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Urinary Bladder |
| Carcinoma or Papilloma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/49 (0%) 0/49 (0%) 0/49 (0%) 1/50 (2%) 2/49 (4%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 2.1% 4.2% |
|TERMINAL (d) | 0/23 (0%) 0/40 (0%) 0/35 (0%) 1/37 (3%) 2/40 (5%) |
|FIRST INCIDENCE | --- --- --- 730 (T) 730 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.050 (e) (e) P=0.595 P=0.367 |
|POLY 3 | P=0.037 * (e) (e) P=0.522 P=0.264 |
|POLY 1.5 | P=0.035 * (e) (e) P=0.514 P=0.251 |
|POLY 6 | P=0.041 * (e) (e) P=0.536 P=0.287 |
|LOGISTIC REGRESSION| (e) (e) (e) P=0.595 P=0.367 |
|COCH-ARM / FISHERS | P=0.033 * (e) (e) P=0.505 P=0.247 |
|=================================================================================================================================|
Date: 02/25/99 EXPERIMENT: 88036 TEST: 03 Page 44
Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - ANTHRAQUINONE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Urinary Bladder |
| Papilloma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 3/50 (6%) 7/50 (14%) 3/49 (6%) |
|POLY-3 ADJUSTED (b)| 0.0% 2.3% 7.0% 15.5% 7.6% |
|TERMINAL (d) | 0/22 (0%) 1/23 (4%) 3/22 (14%) 3/26 (12%) 3/22 (14%) |
|FIRST INCIDENCE | --- 729 (T) 729 (T) 537 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.069 P=0.509 P=0.118 P=0.017 * P=0.118 |
|POLY 3 | P=0.053 P=0.514 P=0.127 P=0.011 * P=0.113 |
|POLY 1.5 | P=0.055 P=0.508 P=0.123 P=0.009 ** P=0.113 |
|POLY 6 | P=0.050 P=0.522 P=0.133 P=0.014 * P=0.115 |
|LOGISTIC REGRESSION| P=0.060 P=0.509 P=0.118 P=0.008 ** P=0.118 |
|COCH-ARM / FISHERS | P=0.067 P=0.500 P=0.121 P=0.006 ** P=0.117 |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Urinary Bladder |
| Papilloma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/49 (0%) 0/49 (0%) 0/49 (0%) 1/50 (2%) 1/49 (2%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 2.1% 2.1% |
|TERMINAL (d) | 0/23 (0%) 0/40 (0%) 0/35 (0%) 1/37 (3%) 1/40 (3%) |
|FIRST INCIDENCE | --- --- --- 730 (T) 730 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.201 (e) (e) P=0.595 P=0.610 |
|POLY 3 | P=0.178 (e) (e) P=0.522 P=0.523 |
|POLY 1.5 | P=0.170 (e) (e) P=0.514 P=0.512 |
|POLY 6 | P=0.191 (e) (e) P=0.536 P=0.541 |
|LOGISTIC REGRESSION| (e) (e) (e) P=0.595 P=0.610 |
|COCH-ARM / FISHERS | P=0.160 (e) (e) P=0.505 P=0.500 |
|=================================================================================================================================|
Date: 02/25/99 EXPERIMENT: 88036 TEST: 03 Page 45
Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - ANTHRAQUINONE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Uterus |
| Leiomyosarcoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | |
|POLY-3 ADJUSTED (b)| |
|TERMINAL (d) | |
|FIRST INCIDENCE | |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | |
|POLY 3 | |
|POLY 1.5 | |
|POLY 6 | |
|LOGISTIC REGRESSION| |
|COCH-ARM / FISHERS | |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Uterus |
| Leiomyosarcoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 2/50 (4%) 0/50 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 4.2% 0.0% |
|TERMINAL (d) | 0/23 (0%) 0/40 (0%) 0/35 (0%) 1/37 (3%) 0/40 (0%) |
|FIRST INCIDENCE | --- --- --- 635 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.544 (e) (e) P=0.302 (e) |
|POLY 3 | P=0.545 (e) (e) P=0.259 (e) |
|POLY 1.5 | P=0.526 (e) (e) P=0.249 (e) |
|POLY 6 | P=0.575 (e) (e) P=0.277 (e) |
|LOGISTIC REGRESSION| P=0.485 (e) (e) P=0.189 (e) |
|COCH-ARM / FISHERS | P=0.504 (e) (e) P=0.247 (e) |
|=================================================================================================================================|
Date: 02/25/99 EXPERIMENT: 88036 TEST: 03 Page 46
Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - ANTHRAQUINONE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | |
|POLY-3 ADJUSTED (b)| |
|TERMINAL (d) | |
|FIRST INCIDENCE | |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | |
|POLY 3 | |
|POLY 1.5 | |
|POLY 6 | |
|LOGISTIC REGRESSION| |
|COCH-ARM / FISHERS | |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 7/50 (14%) 9/50 (18%) 9/50 (18%) 4/50 (8%) 5/50 (10%) |
|POLY-3 ADJUSTED (b)| 15.7% 19.2% 19.9% 8.4% 10.4% |
|TERMINAL (d) | 2/23 (9%) 8/40 (20%) 8/35 (23%) 3/37 (8%) 3/40 (8%) |
|FIRST INCIDENCE | 605 592 655 638 689 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.051N P=0.506N P=0.574N P=0.137N P=0.164N |
|POLY 3 | P=0.104N P=0.437 P=0.405 P=0.226N P=0.323N |
|POLY 1.5 | P=0.118N P=0.416 P=0.391 P=0.243N P=0.350N |
|POLY 6 | P=0.085N P=0.475 P=0.434 P=0.202N P=0.281N |
|LOGISTIC REGRESSION| P=0.127N P=0.365 P=0.400 P=0.365N P=0.472N |
|COCH-ARM / FISHERS | P=0.136N P=0.393 P=0.393 P=0.262N P=0.380N |
|=================================================================================================================================|
Date: 02/25/99 EXPERIMENT: 88036 TEST: 03 Page 47
Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - ANTHRAQUINONE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal or Polyp Stromal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | |
|POLY-3 ADJUSTED (b)| |
|TERMINAL (d) | |
|FIRST INCIDENCE | |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | |
|POLY 3 | |
|POLY 1.5 | |
|POLY 6 | |
|LOGISTIC REGRESSION| |
|COCH-ARM / FISHERS | |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal or Polyp Stromal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 7/50 (14%) 9/50 (18%) 9/50 (18%) 4/50 (8%) 5/50 (10%) |
|POLY-3 ADJUSTED (b)| 15.7% 19.2% 19.9% 8.4% 10.4% |
|TERMINAL (d) | 2/23 (9%) 8/40 (20%) 8/35 (23%) 3/37 (8%) 3/40 (8%) |
|FIRST INCIDENCE | 605 592 655 638 689 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.051N P=0.506N P=0.574N P=0.137N P=0.164N |
|POLY 3 | P=0.104N P=0.437 P=0.405 P=0.226N P=0.323N |
|POLY 1.5 | P=0.118N P=0.416 P=0.391 P=0.243N P=0.350N |
|POLY 6 | P=0.085N P=0.475 P=0.434 P=0.202N P=0.281N |
|LOGISTIC REGRESSION| P=0.127N P=0.365 P=0.400 P=0.365N P=0.472N |
|COCH-ARM / FISHERS | P=0.136N P=0.393 P=0.393 P=0.262N P=0.380N |
|=================================================================================================================================|
Date: 02/25/99 EXPERIMENT: 88036 TEST: 03 Page 48
Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - ANTHRAQUINONE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Zymbal's Gland |
| Carcinoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 2/50 (4%) 0/50 (0%) 0/50 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 4.6% 0.0% 0.0% |
|TERMINAL (d) | 0/22 (0%) 0/23 (0%) 0/22 (0%) 0/26 (0%) 0/22 (0%) |
|FIRST INCIDENCE | --- --- 477 --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.528N (e) P=0.249 (e) (e) |
|POLY 3 | P=0.510N (e) P=0.253 (e) (e) |
|POLY 1.5 | P=0.515N (e) P=0.245 (e) (e) |
|POLY 6 | P=0.502N (e) P=0.264 (e) (e) |
|LOGISTIC REGRESSION| P=0.395N (e) P=0.260 (e) (e) |
|COCH-ARM / FISHERS | P=0.516N (e) P=0.247 (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|Zymbal's Gland |
| Carcinoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 1/50 (2%) 1/50 (2%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|POLY-3 ADJUSTED (b)| 2.3% 2.1% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/23 (0%) 0/40 (0%) 0/35 (0%) 0/37 (0%) 0/40 (0%) |
|FIRST INCIDENCE | 676 589 --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.206N P=0.733N P=0.468N P=0.459N P=0.437N |
|POLY 3 | P=0.221N P=0.742N P=0.492N P=0.483N P=0.479N |
|POLY 1.5 | P=0.221N P=0.751N P=0.498N P=0.491N P=0.489N |
|POLY 6 | P=0.221N P=0.726N P=0.481N P=0.471N P=0.462N |
|LOGISTIC REGRESSION| P=0.241N P=0.722 P=0.498N P=0.550N P=0.542N |
|COCH-ARM / FISHERS | P=0.222N P=0.753N P=0.500N P=0.500N P=0.500N |
|=================================================================================================================================|
Date: 02/25/99 EXPERIMENT: 88036 TEST: 03 Page 49
Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - ANTHRAQUINONE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|All Organs |
| Leukemia: Lymphocytic, Monocytic, Mononuclear, or |
| Undifferentiated |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 25/50 (50%) 2/50 (4%) 1/50 (2%) 5/50 (10%) 7/50 (14%) |
|POLY-3 ADJUSTED (b)| 56.4% 4.5% 2.3% 11.4% 16.7% |
|TERMINAL (d) | 12/22 (55%) 0/23 (0%) 0/22 (0%) 3/26 (12%) 3/22 (14%) |
|FIRST INCIDENCE | 499 668 705 674 607 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.011N* P<0.001N** P<0.001N** P<0.001N** P<0.001N** |
|POLY 3 | P=0.003N** P<0.001N** P<0.001N** P<0.001N** P<0.001N** |
|POLY 1.5 | P=0.004N** P<0.001N** P<0.001N** P<0.001N** P<0.001N** |
|POLY 6 | P=0.003N** P<0.001N** P<0.001N** P<0.001N** P<0.001N** |
|LOGISTIC REGRESSION| P=0.010N* P<0.001N** P<0.001N** P<0.001N** P<0.001N** |
|COCH-ARM / FISHERS | P=0.009N** P<0.001N** P<0.001N** P<0.001N** P<0.001N** |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|All Organs |
| Leukemia: Lymphocytic, Monocytic, Mononuclear, or |
| Undifferentiated |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 18/50 (36%) 1/50 (2%) 1/50 (2%) 2/50 (4%) 0/50 (0%) |
|POLY-3 ADJUSTED (b)| 38.0% 2.2% 2.2% 4.2% 0.0% |
|TERMINAL (d) | 2/23 (9%) 1/40 (3%) 1/35 (3%) 1/37 (3%) 0/40 (0%) |
|FIRST INCIDENCE | 571 730 (T) 730 (T) 634 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001N** P<0.001N** P<0.001N** P<0.001N** P<0.001N** |
|POLY 3 | P<0.001N** P<0.001N** P<0.001N** P<0.001N** P<0.001N** |
|POLY 1.5 | P<0.001N** P<0.001N** P<0.001N** P<0.001N** P<0.001N** |
|POLY 6 | P<0.001N** P<0.001N** P<0.001N** P<0.001N** P<0.001N** |
|LOGISTIC REGRESSION| P<0.001N** P<0.001N** P<0.001N** P<0.001N** P<0.001N** |
|COCH-ARM / FISHERS | P<0.001N** P<0.001N** P<0.001N** P<0.001N** P<0.001N** |
|=================================================================================================================================|
Date: 02/25/99 EXPERIMENT: 88036 TEST: 03 Page 50
Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - ANTHRAQUINONE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|All Organs |
| Mesothelioma: Benign, Malignant, NOS |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 4/50 (8%) 4/50 (8%) 5/50 (10%) 4/50 (8%) 0/50 (0%) |
|POLY-3 ADJUSTED (b)| 9.7% 9.0% 11.5% 9.0% 0.0% |
|TERMINAL (d) | 2/22 (9%) 0/23 (0%) 0/22 (0%) 1/26 (4%) 0/22 (0%) |
|FIRST INCIDENCE | 617 645 603 593 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.051N P=0.570N P=0.556 P=0.558N P=0.066N |
|POLY 3 | P=0.053N P=0.601N P=0.533 P=0.602N P=0.062N |
|POLY 1.5 | P=0.052N P=0.620N P=0.516 P=0.622N P=0.062N |
|POLY 6 | P=0.055N P=0.576N P=0.559 P=0.573N P=0.061N |
|LOGISTIC REGRESSION| P=0.043N* P=0.618 P=0.499 P=0.634 P=0.064N |
|COCH-ARM / FISHERS | P=0.047N* P=0.643N P=0.500 P=0.643N P=0.059N |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|All Organs |
| Mesothelioma: Benign, Malignant, NOS |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/23 (0%) 0/40 (0%) 0/35 (0%) 0/37 (0%) 0/40 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 02/25/99 EXPERIMENT: 88036 TEST: 03 Page 51
Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - ANTHRAQUINONE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|All Organs |
| Mesothelioma: Malignant |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 4/50 (8%) 4/50 (8%) 5/50 (10%) 4/50 (8%) 0/50 (0%) |
|POLY-3 ADJUSTED (b)| 9.7% 9.0% 11.5% 9.0% 0.0% |
|TERMINAL (d) | 2/22 (9%) 0/23 (0%) 0/22 (0%) 1/26 (4%) 0/22 (0%) |
|FIRST INCIDENCE | 617 645 603 593 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.051N P=0.570N P=0.556 P=0.558N P=0.066N |
|POLY 3 | P=0.053N P=0.601N P=0.533 P=0.602N P=0.062N |
|POLY 1.5 | P=0.052N P=0.620N P=0.516 P=0.622N P=0.062N |
|POLY 6 | P=0.055N P=0.576N P=0.559 P=0.573N P=0.061N |
|LOGISTIC REGRESSION| P=0.043N* P=0.618 P=0.499 P=0.634 P=0.064N |
|COCH-ARM / FISHERS | P=0.047N* P=0.643N P=0.500 P=0.643N P=0.059N |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|All Organs |
| Mesothelioma: Malignant |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/23 (0%) 0/40 (0%) 0/35 (0%) 0/37 (0%) 0/40 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 02/25/99 EXPERIMENT: 88036 TEST: 03 Page 52
Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - ANTHRAQUINONE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 50/50 (100%) 50/50 (100%) 48/50 (96%) 50/50 (100%) 48/50 (96%) |
|POLY-3 ADJUSTED (b)| 100.0% 100.0% 99.3% 100.0% 98.2% |
|TERMINAL (d) | 22/22 (100%) 23/23 (100%) 22/22 (100%) 26/26 (100%) 22/22 (100%) |
|FIRST INCIDENCE | 485 477 561 249 421 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.438N (e) P=0.307N (e) P=0.412N |
|POLY 3 | P=0.212N (e) P=0.985N (e) P=0.549N |
|POLY 1.5 | P=0.251N (e) P=0.619N (e) P=0.511N |
|POLY 6 | P=0.205N (e) P=1.000N (e) P=0.608N |
|LOGISTIC REGRESSION| P=0.440N (e) (e) (e) P=0.437N |
|COCH-ARM / FISHERS | P=0.137N (e) P=0.247N (e) P=0.247N |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 39/50 (78%) 45/50 (90%) 44/50 (88%) 40/50 (80%) 41/50 (82%) |
|POLY-3 ADJUSTED (b)| 81.1% 90.6% 92.0% 80.6% 83.2% |
|TERMINAL (d) | 18/23 (78%) 36/40 (90%) 32/35 (91%) 28/37 (76%) 33/40 (83%) |
|FIRST INCIDENCE | 550 513 570 550 536 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.010N* P=0.046N* P=0.130N P=0.029N* P=0.006N** |
|POLY 3 | P=0.303N P=0.137 P=0.090 P=0.575N P=0.499 |
|POLY 1.5 | P=0.346N P=0.110 P=0.088 P=0.574 P=0.449 |
|POLY 6 | P=0.241N P=0.186 P=0.109 P=0.498N P=0.581 |
|LOGISTIC REGRESSION| P=0.286N P=0.107 P=0.137 P=0.535 P=0.551 |
|COCH-ARM / FISHERS | P=0.409N P=0.086 P=0.143 P=0.500 P=0.402 |
|=================================================================================================================================|
Date: 02/25/99 EXPERIMENT: 88036 TEST: 03 Page 53
Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - ANTHRAQUINONE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 30/50 (60%) 14/50 (28%) 15/50 (30%) 18/50 (36%) 14/50 (28%) |
|POLY-3 ADJUSTED (b)| 64.8% 30.4% 32.1% 39.8% 31.9% |
|TERMINAL (d) | 13/22 (59%) 3/23 (13%) 3/22 (14%) 9/26 (35%) 4/22 (18%) |
|FIRST INCIDENCE | 485 477 312 593 466 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.045N* P=0.003N** P=0.007N** P=0.007N** P=0.006N** |
|POLY 3 | P=0.026N* P<0.001N** P<0.001N** P=0.011N* P<0.001N** |
|POLY 1.5 | P=0.025N* P<0.001N** P<0.001N** P=0.012N* P<0.001N** |
|POLY 6 | P=0.027N* P<0.001N** P<0.001N** P=0.010N* P<0.001N** |
|LOGISTIC REGRESSION| P=0.018N* P=0.002N** P=0.003N** P=0.012N* P<0.001N** |
|COCH-ARM / FISHERS | P=0.022N* P<0.001N** P=0.002N** P=0.014N* P<0.001N** |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 24/50 (48%) 9/50 (18%) 11/50 (22%) 9/50 (18%) 10/50 (20%) |
|POLY-3 ADJUSTED (b)| 50.3% 19.0% 23.0% 18.5% 20.7% |
|TERMINAL (d) | 4/23 (17%) 6/40 (15%) 5/35 (14%) 4/37 (11%) 7/40 (18%) |
|FIRST INCIDENCE | 571 589 85 611 709 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.006N** P<0.001N** P=0.003N** P<0.001N** P<0.001N** |
|POLY 3 | P=0.013N* P<0.001N** P=0.004N** P<0.001N** P=0.002N** |
|POLY 1.5 | P=0.015N* P<0.001N** P=0.004N** P<0.001N** P=0.002N** |
|POLY 6 | P=0.012N* P<0.001N** P=0.004N** P<0.001N** P<0.001N** |
|LOGISTIC REGRESSION| P=0.062N P=0.004N** P=0.009N** P=0.012N* P=0.010N* |
|COCH-ARM / FISHERS | P=0.019N* P<0.001N** P=0.006N** P<0.001N** P=0.003N** |
|=================================================================================================================================|
Date: 02/25/99 EXPERIMENT: 88036 TEST: 03 Page 54
Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - ANTHRAQUINONE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 50/50 (100%) 50/50 (100%) 50/50 (100%) 50/50 (100%) 49/50 (98%) |
|POLY-3 ADJUSTED (b)| 100.0% 100.0% 100.0% 100.0% 100.0% |
|TERMINAL (d) | 22/22 (100%) 23/23 (100%) 22/22 (100%) 26/26 (100%) 22/22 (100%) |
|FIRST INCIDENCE | 485 477 312 249 421 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.480N (e) (e) (e) P=0.467N |
|POLY 3 | P=1.000N (e) (e) (e) P=1.000N |
|POLY 1.5 | P=1.000N (e) (e) (e) P=1.000N |
|POLY 6 | P=1.000N (e) (e) (e) P=1.000N |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.145N (e) (e) (e) P=0.500N |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 PPM 469 PPM 938 PPM 1875 PPM 3750 PPM |
| | |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 46/50 (92%) 46/50 (92%) 47/50 (94%) 42/50 (84%) 45/50 (90%) |
|POLY-3 ADJUSTED (b)| 92.0% 92.0% 94.0% 84.0% 91.3% |
|TERMINAL (d) | 19/23 (83%) 36/40 (90%) 32/35 (91%) 29/37 (78%) 37/40 (93%) |
|FIRST INCIDENCE | 550 513 85 550 536 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.006N** P=0.005N** P=0.047N* P=0.004N** P<0.001N** |
|POLY 3 | P=0.360N P=0.642 P=0.500 P=0.179N P=0.596N |
|POLY 1.5 | P=0.329N P=0.642 P=0.500 P=0.179N P=0.561N |
|POLY 6 | P=0.390N P=0.642 P=0.500 P=0.179N P=0.627N |
|LOGISTIC REGRESSION| P=0.369N (e) (e) (e) P=0.484N |
|COCH-ARM / FISHERS | P=0.276N P=0.643N P=0.500 P=0.178N P=0.500N |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Poly-3 adjusted lifetime tumor incidence.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death.
Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).