TDMS Study 88036-04 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus ANTHRAQUINONE DATE: 12/11/98
EXPERIMENT: 88036 TEST: 04 TIME: 09:07:54
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1-ES-25337 ROUTE: DOSED FEED NTP C#: C88036
PATHOLOGIST: RYAN, M. CAS: 84-65-1
------------------------------------------------------------------------------------------------------------------------------------
2 YEAR CHRONIC MICE
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus ANTHRAQUINONE DATE: 12/11/98
EXPERIMENT: 88036 TEST: 04 TIME: 09:07:54
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-25337 ROUTE: DOSED FEED NTP C#: C88036
PATHOLOGIST: RYAN, M. CAS: 84-65-1
ANTHRAQUINONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 5 CENSORED DEATHS 0 TERMINAL 45 |
| |
| UNCENSORED DEATHS |
| 15 550 662 702 710 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 833 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 9 CENSORED DEATHS 0 TERMINAL 41 |
| |
| UNCENSORED DEATHS |
| 456 464 601 657 658 662 666 677 710 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 2500 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 7 CENSORED DEATHS 0 TERMINAL 43 |
| |
| UNCENSORED DEATHS |
| 453 481 491 662 685 711 727 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
ANTHRAQUINONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 7500 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 27 CENSORED DEATHS 0 TERMINAL 23 |
| |
| UNCENSORED DEATHS |
| 456 490 497 540 554 559 569 570 586 590 |
| 617 621 621 623 638 638 642 647 647 658 |
| 664 687 690 690 702 707 708 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
ANTHRAQUINONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM | 98.0 98.0 98.0 98.0 98.0 98.0 98.0 96.0 94.0 90.0 |
| | |
| | |
|833 PPM | 100.0 100.0 100.0 100.0 100.0 96.0 96.0 94.0 88.0 82.0 |
| | |
| | |
|2500 PPM | 100.0 100.0 100.0 100.0 100.0 96.0 94.0 94.0 92.0 86.0 |
| | |
| | |
|7500 PPM | 100.0 100.0 100.0 100.0 100.0 98.0 92.0 80.0 58.0 46.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 833 PPM 2500 PPM 7500 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 90.0% 82.0% 86.0% 46.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P<0.001 P=0.374 P=0.751 P<0.001 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 527.8 616.8 601.4 615.2 |
|NATURAL DEATHS (C) | ( 131) (31.1) (45.6) (13.2) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 708.9 708.8 711.1 667.6 |
|(STANDARD ERROR) | (14.7) ( 8.1) ( 8.7) (10.7) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
ANTHRAQUINONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 730 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 15 CENSORED DEATHS 0 TERMINAL 35 |
| |
| UNCENSORED DEATHS |
| 242 519 554 554 569 613 617 627 652 690 |
| 701 715 717 717 717 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 833 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 8 CENSORED DEATHS 0 TERMINAL 42 |
| |
| UNCENSORED DEATHS |
| 499 519 549 575 611 648 694 703 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 2500 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 12 CENSORED DEATHS 3 TERMINAL 35 |
| |
| UNCENSORED DEATHS |
| 491 505 568 589 599 624 626 627 631 700 |
| 700 711 |
| CENSORED DEATHS |
| 675 675 676 |
| |
==================================================================================
ANTHRAQUINONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 730 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 7500 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 7 CENSORED DEATHS 1 TERMINAL 42 |
| |
| UNCENSORED DEATHS |
| 172 186 477 549 625 681 711 |
| CENSORED DEATHS |
| 680 |
| |
==================================================================================
ANTHRAQUINONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 730 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 730 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM | 100.0 100.0 98.0 98.0 98.0 98.0 96.0 90.0 82.0 70.0 |
| | |
| | |
|833 PPM | 100.0 100.0 100.0 100.0 100.0 100.0 96.0 92.0 88.0 84.0 |
| | |
| | |
|2500 PPM | 100.0 100.0 100.0 100.0 100.0 100.0 96.0 90.0 82.0 75.5 |
| | |
| | |
|7500 PPM | 100.0 98.0 96.0 96.0 96.0 94.0 94.0 92.0 90.0 85.9 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 833 PPM 2500 PPM 7500 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 70.0% 84.0% 75.5% 85.9% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.227N P=0.175N P=0.737N P=0.117N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 613.6 599.8 614.3 485.9 |
|NATURAL DEATHS (C) | (31.9) (27.3) (20.4) (84.6) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 695.1 709.2 698.9 694.8 |
|(STANDARD ERROR) | (12.1) ( 8.0) ( 8.5) (16.4) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
ANTHRAQUINONE
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
833 PPM = 2
2500 PPM = 3
7500 PPM = 4
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 32
| 1 322 34 1
| 2 343 41 2 2 1 1
| 4 4 3 3 11
P 90 + 2 2 3 1 1
E | 4 4 22 3 3
R | 4 4 22 2 3 3
C | 4 4 2 2
E 80 + 4 4
N |
T |
| 4 4
S 70 +
U |
R | 44
V | 44
I 60 + 4 4
V | 4 4
A |
L | 4 4
50 +
| 44
| 4 4
|
40 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 13 obs hidden.
ANTHRAQUINONE
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
833 PPM = 2
2500 PPM = 3
7500 PPM = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 4 1 32
|
| 4 4 1 323 1
| 4 4 3 1 21 3
P 95 +
E | 4 2 32 3
R | 41 12 33 2 4
C |
E 90 + 1 3 1 3 2 4
N |
T | 11 2 4 2 4
| 11 224 4
S 85 +
U | 13 1 2 2
R | 3 1 13
V |
I 80 + 1 1
V |
A | 3131
L |
75 + 3 3
|
|
|
70 + 1 1
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 9 obs hidden.