TDMS Study 88050-06 Pathology Tables
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
FINAL#1, CORE STUDY MICE
Facility: Battelle Columbus Laboratory
Chemical CAS #: 126-98-7
Lock Date: 06/26/98
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 9| 3| 4| 3| 3| 3| 0| 0| 2| 0| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3|
| 3| 1| 5| 1| 2| 2| 7| 9| 3| 4| 2| 3| 2| 1| 1| 2| 2| 2| 1| 1| 2| 1| 1| 5| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Periesophageal Tissue, Inflammation, | |
Chronic Active | 2 |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Epithelium, Ulcer | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | X X |
Eosinophilic Focus | X X |
Hematopoietic Cell Proliferation | 1 |
Infiltration Cellular, Mononuclear | |
Cell | 1 2 1 1 2 2 1 1 1 1 1 1 1 1 1|
Inflammation, Chronic Active | 1 1 1 1 2 2 1 2 1 1 1 1 1 1 1 1|
Mixed Cell Focus | |
Necrosis | 2 4 |
Pigmentation | 1 1 1 1 1 1 1|
Tension Lipidosis | |
Hepatocyte, Vacuolization Cytoplasmic| 1 2 2 |
__________________________________________________________________________|
Mesentery | + + + + + + + + |
Fibrosis | 4 2 2 2 |
Inflammation, Chronic Active | 2 3 1 |
Mineralization | 1 2 |
Fat, Necrosis | 4 4 4 4 |
__________________________________________________________________________|
Oral Mucosa | + +|
Gingival, Foreign Body | X X|
Gingival, Inflammation, Chronic | |
Active | 2 2|
Pharyngeal, Foreign Body | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + M + + + M + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mononuclear | |
Cell | 1 1 1 1 1 2 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | |
Epithelium, Hyperplasia | 1 3 3 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 9| 3| 4| 3| 3| 3| 0| 0| 2| 0| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3|
| 3| 1| 5| 1| 2| 2| 7| 9| 3| 4| 2| 3| 2| 1| 1| 2| 2| 2| 1| 1| 2| 1| 1| 5| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Epithelium, Inflammation, Chronic | |
Active | 1 |
Epithelium, Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1|
Epithelium, Erosion | |
Glands, Ectasia | 1 1 1 2 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + M + + + + + + + + + + + + + + + + + +|
Aorta, Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 |
Artery, Mineralization | |
Valve, Inflammation, Suppurative | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypertrophy | 2 |
Capsule, Hyperplasia | 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + M + + + M + + M + + + + + M + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + I + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 1 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 2 2 1 |
__________________________________________________________________________|
Thyroid Gland | + + M + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mononuclear | |
Cell | |
Inflammation, Chronic Active | |
Follicle, Cyst | 2 2 2 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mononuclear | |
Cell | 1 1 1 |
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 9| 3| 4| 3| 3| 3| 0| 0| 2| 0| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3|
| 3| 1| 5| 1| 2| 2| 7| 9| 3| 4| 2| 3| 2| 1| 1| 2| 2| 2| 1| 1| 2| 1| 1| 5| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 2 2 2 2 4 2 |
Mineralization | |
Pigmentation | 1 1 1 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 4 2 2 4 2 4 4 4 4 4 4 |
Inflammation, Chronic Active | 3 |
Thrombosis | 4 |
Endometrium, Hyperplasia, Cystic | 3 2 2 1 2 1 2 2 1 2 1|
Endometrium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + |
Mediastinal, Hyperplasia, Lymphoid | |
Mediastinal, Infiltration Cellular, | |
Histiocyte | |
Pancreatic, Fibrosis | 2 |
Pancreatic, Hyperplasia, Lymphoid | 3 |
Pancreatic, Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + M + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 4 3 3 4|
Infiltration Cellular, Plasma Cell | |
Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 4 4 |
Hemorrhage | 2 2 |
Hyperplasia, Lymphoid | 3 4|
Pigmentation | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 3 2 3 2 2 2 3 2 3|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 1 2 2 2 2 2 1 1 1 |
Ectopic Parathyroid Gland | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 3 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 |
Epidermis, Ulcer | 4 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 9| 3| 4| 3| 3| 3| 0| 0| 2| 0| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3|
| 3| 1| 5| 1| 2| 2| 7| 9| 3| 4| 2| 3| 2| 1| 1| 2| 2| 2| 1| 1| 2| 1| 1| 5| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteosclerosis | 4|
__________________________________________________________________________|
Skeletal Muscle | + + |
Infiltration Cellular, Mononuclear | |
Cell | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mononuclear | |
Cell | 1 |
__________________________________________________________________________|
Peripheral Nerve | + |
Sciatic, Axon, Degeneration | 2 |
__________________________________________________________________________|
Spinal Cord | + |
Demyelination | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Mineralization | 1 1 |
Pigmentation | 1 |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 3 |
Artery, Mediastinum, Mineralization | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Atrophy | 4 |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accumulation, Hyaline Droplet | 3 3 |
Infarct, Multiple | 2 |
Infiltration Cellular, Mononuclear | |
Cell | 1 1 1 1 1 2 1 1 1 2 1 1 1 1 1 2|
Inflammation, Chronic Active | |
Mineralization | 1 |
Nephropathy | 1 2 1 2 2 1 1 1|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 9| 3| 4| 3| 3| 3| 0| 0| 2| 0| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3|
| 3| 1| 5| 1| 2| 2| 7| 9| 3| 4| 2| 3| 2| 1| 1| 2| 2| 2| 1| 1| 2| 1| 1| 5| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Capsule, Mineralization | |
Cortex, Cyst | |
Papilla, Inflammation, Acute | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mononuclear | |
Cell | 2 1 1 1 1 1 1 1 4 1 1 1 1|
Inflammation, Chronic Active | |
Pigmentation | 2 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 6| 7| 4| 7| 7| |
DAY ON TEST | 6| 3| 3| 8| 3| 3| 7| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 6| 6| 3| 9| 3| 3| |
| 2| 2| 1| 7| 2| 1| 1| 2| 2| 1| 7| 2| 1| 1| 2| 2| 2| 2| 2| 2| 8| 2| 2| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Periesophageal Tissue, Inflammation, | | |
Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + M + +| 49 |
Inflammation, Chronic Active | 4| 1 4.0|
Epithelium, Ulcer | 4| 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X | 1 |
Clear Cell Focus | X | 3 |
Eosinophilic Focus | X X X X X X X | 9 |
Hematopoietic Cell Proliferation | 2 | 2 1.5|
Infiltration Cellular, Mononuclear | | |
Cell | 2 1 1 1 1 1 1 1 1 2 1 2 2 1 1| 30 1.2|
Inflammation, Chronic Active | 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1| 32 1.1|
Mixed Cell Focus | X X X | 3 |
Necrosis | 1 | 3 2.3|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1| 18 1.0|
Tension Lipidosis | X X | 2 |
Hepatocyte, Vacuolization Cytoplasmic| 2 1 2 2 | 7 1.7|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + + | 16 |
Fibrosis | 2 3 3 2 | 8 2.5|
Inflammation, Chronic Active | 2 2 | 5 2.0|
Mineralization | 2 1 2 | 5 1.6|
Fat, Necrosis | 4 4 4 4 | 8 4.0|
__________________________________________________________________________|____________|
Oral Mucosa | + | 3 |
Gingival, Foreign Body | | 2 |
Gingival, Inflammation, Chronic | | |
Active | | 2 2.0|
Pharyngeal, Foreign Body | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 4 | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 6| 7| 4| 7| 7| |
DAY ON TEST | 6| 3| 3| 8| 3| 3| 7| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 6| 6| 3| 9| 3| 3| |
| 2| 2| 1| 7| 2| 1| 1| 2| 2| 1| 7| 2| 1| 1| 2| 2| 2| 2| 2| 2| 8| 2| 2| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Infiltration Cellular, Mononuclear | | |
Cell | 1 2 1 1 1 1 1 1 1 1 1 1 1| 27 1.1|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Diverticulum | X | 1 |
Epithelium, Hyperplasia | | 3 2.3|
Epithelium, Inflammation, Chronic | | |
Active | | 1 1.0|
Epithelium, Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | | 1 1.0|
Epithelium, Erosion | 2 | 1 2.0|
Glands, Ectasia | 1 1 1 1 1 1 1 | 16 1.1|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Aorta, Mineralization | 2 | 1 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | | 1 1.0|
Artery, Mineralization | 2 | 1 2.0|
Valve, Inflammation, Suppurative | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 |
Hypertrophy | | 1 2.0|
Capsule, Hyperplasia | 2 2 2 1 2 2 1 2 2 2 2 2 2 2 3 2 2 1 2 3 2 2 2| 48 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 41 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + M + + + + M + M + + + + + + + + + M +| 39 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Angiectasis | 1 | 2 1.0|
Pars Distalis, Cyst | 1 | 1 1.0|
Pars Distalis, Hyperplasia | 1 1 1 2 2 | 9 1.6|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Infiltration Cellular, Mononuclear | | |
Cell | 1 | 1 1.0|
Inflammation, Chronic Active | 2 | 1 2.0|
Follicle, Cyst | 2 2 | 5 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 6| 7| 4| 7| 7| |
DAY ON TEST | 6| 3| 3| 8| 3| 3| 7| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 6| 6| 3| 9| 3| 3| |
| 2| 2| 1| 7| 2| 1| 1| 2| 2| 1| 7| 2| 1| 1| 2| 2| 2| 2| 2| 2| 8| 2| 2| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Follicular Cell, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Mononuclear | | |
Cell | 1 | 4 1.0|
Inflammation, Chronic Active | 1 | 2 1.5|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 4 2 2 3 4 3 4 2| 17 2.6|
Mineralization | 2 2 | 2 2.0|
Pigmentation | 2 2 2 2 | 7 1.6|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrometra | 2 4 4 4 2 4 3 2 1 4 3 3| 23 3.2|
Inflammation, Chronic Active | | 1 3.0|
Thrombosis | | 1 4.0|
Endometrium, Hyperplasia, Cystic | 2 1 2 2 2 2 2 2 1 2 2 2 1 2 3 2| 27 1.8|
Endometrium, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 2 3.0|
Myelofibrosis | 2 3 | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + | 9 |
Mediastinal, Hyperplasia, Lymphoid | 4 | 1 4.0|
Mediastinal, Infiltration Cellular, | | |
Histiocyte | 4 | 1 4.0|
Pancreatic, Fibrosis | | 1 2.0|
Pancreatic, Hyperplasia, Lymphoid | | 1 3.0|
Pancreatic, Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia, Lymphoid | 2 | 5 3.2|
Infiltration Cellular, Plasma Cell | 3 | 1 3.0|
Pigmentation | 2 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + M + + + + + + + + + + M + + + + M + +| 47 |
Ectasia | | 2 4.0|
Hemorrhage | | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 6| 7| 4| 7| 7| |
DAY ON TEST | 6| 3| 3| 8| 3| 3| 7| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 6| 6| 3| 9| 3| 3| |
| 2| 2| 1| 7| 2| 1| 1| 2| 2| 1| 7| 2| 1| 1| 2| 2| 2| 2| 2| 2| 8| 2| 2| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia, Lymphoid | | 2 3.5|
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 2 2 3 3 3 3 2 3| 18 2.5|
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + M + + + M + M + +| 47 |
Cyst | 2 2 2 1 2 1 2 2 2 2| 20 1.7|
Ectopic Parathyroid Gland | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 |
Hyperplasia, Cystic | 4 | 3 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 4.0|
Epidermis, Ulcer | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Osteosclerosis | | 1 4.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + + | 4 |
Infiltration Cellular, Mononuclear | | |
Cell | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Mononuclear | | |
Cell | 1 | 2 1.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
Sciatic, Axon, Degeneration | | 1 2.0|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
Demyelination | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 1 | 2 1.5|
Mineralization | 1 1 1 | 5 1.0|
Pigmentation | | 1 1.0|
Alveolar Epithelium, Hyperplasia | 1 | 1 1.0|
Alveolus, Infiltration Cellular, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 6| 7| 4| 7| 7| |
DAY ON TEST | 6| 3| 3| 8| 3| 3| 7| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 6| 6| 3| 9| 3| 3| |
| 2| 2| 1| 7| 2| 1| 1| 2| 2| 1| 7| 2| 1| 1| 2| 2| 2| 2| 2| 2| 8| 2| 2| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Histiocyte | | 1 3.0|
Artery, Mediastinum, Mineralization | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Atrophy | | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + + | 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accumulation, Hyaline Droplet | | 2 3.0|
Infarct, Multiple | | 1 2.0|
Infiltration Cellular, Mononuclear | | |
Cell | 1 1 1 2 1 1 1 1 1 1 2 2 2 1 1 1 2 1 1| 35 1.2|
Inflammation, Chronic Active | 1 | 1 1.0|
Mineralization | 1 1 1 1 | 5 1.0|
Nephropathy | 2 1 1 1 1 2 1| 15 1.3|
Capsule, Mineralization | 2 | 1 2.0|
Cortex, Cyst | 2 2 | 2 2.0|
Papilla, Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Mononuclear | | |
Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 | 28 1.2|
Inflammation, Chronic Active | 4 | 1 4.0|
Pigmentation | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 4| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 6| 7| 3| 2| 3| 3| 3| 0| 3| 4| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3|
| 0| 1| 2| 0| 8| 7| 6| 1| 1| 1| 2| 2| 9| 1| 4| 2| 2| 1| 2| 2| 0| 1| 1| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.5 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 4 |
Epithelium, Inflammation, Suppurative| 4 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X X X |
Clear Cell Focus | X X X X X |
Eosinophilic Focus | X X |
Hematopoietic Cell Proliferation | 2 1 |
Hepatodiaphragmatic Nodule | X |
Infiltration Cellular, Mononuclear | |
Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Inflammation, Chronic Active | 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Mixed Cell Focus | |
Necrosis | 2 |
Pigmentation | 1 1 1 1 1 1 1 1 1 |
Tension Lipidosis | X |
Hepatocyte, Vacuolization Cytoplasmic| 2 1 1 2 |
__________________________________________________________________________|
Mesentery | + + + + + |
Fibrosis | 2 2 2 2 |
Hemorrhage | 4 |
Inflammation, Chronic Active | 2 2 3 |
Mineralization | 2 2 2 3 |
Fat, Necrosis | 4 4 4 4 |
__________________________________________________________________________|
Oral Mucosa | + + |
Gingival, Foreign Body | X X |
Gingival, Inflammation, Chronic | |
Active | 1 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mononuclear | |
Cell | 1 1 1 1 1 1 1 1 2 1 2 1 1 1 1 1 1|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 4 |
Epithelium, Hyperplasia | 2 2 |
Epithelium, Inflammation, Chronic | |
Active | 1 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 4| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 6| 7| 3| 2| 3| 3| 3| 0| 3| 4| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3|
| 0| 1| 2| 0| 8| 7| 6| 1| 1| 1| 2| 2| 9| 1| 4| 2| 2| 1| 2| 2| 0| 1| 1| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.5 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Epithelium, Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | |
Mineralization | |
Epithelium, Dysplasia | |
Glands, Ectasia | 1 2 1 1 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Valve, Inflammation, Chronic Active | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 |
Infiltration Cellular, Mononuclear | |
Cell | |
Capsule, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + + + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + I + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 |
Pars Distalis, Hemorrhage | |
Pars Distalis, Hyperplasia | 2 2 3 2 1|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | |
Follicle, Cyst | 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mononuclear | |
Cell | 1 |
Inflammation, Chronic Active | |
Pigmentation | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Cyst | 4 2 2 3 2 3 4 |
Hemorrhage | |
Mineralization | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 4| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 6| 7| 3| 2| 3| 3| 3| 0| 3| 4| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3|
| 0| 1| 2| 0| 8| 7| 6| 1| 1| 1| 2| 2| 9| 1| 4| 2| 2| 1| 2| 2| 0| 1| 1| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.5 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Pigmentation | 2 2 2 2 2 1 2 2 2|
Thrombosis | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 4 3 3 2 2 2 4 4 4 3 2 2 3 2 3 3|
Inflammation, Suppurative | |
Pigmentation | 2 |
Endometrium, Hyperplasia, Cystic | 2 3 2 3 2 2 2 2 2 3 1 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 |
Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + |
Lumbar, Ectasia | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 4 |
Pigmentation | 1 1 1 2 2 1 1 1 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + I + + + + + + + M + + + + + + + + + + + +|
Hemorrhage | 2 |
Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 3 2 4 4 2 2 2 3 2 2 2 3 |
Hyperplasia, Lymphoid | |
Necrosis | 2 |
__________________________________________________________________________|
Thymus | + + + + M + + + + + + + + + + + + + + + + M + M +|
Cyst | 2 3 2 2 2 2 2 2|
Ectopic Parathyroid Gland | 2 |
Thymocyte, Necrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Chronic Active | 1 |
Meninges, Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 4| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 6| 7| 3| 2| 3| 3| 3| 0| 3| 4| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3|
| 0| 1| 2| 0| 8| 7| 6| 1| 1| 1| 2| 2| 9| 1| 4| 2| 2| 1| 2| 2| 0| 1| 1| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.5 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Inflammation, Chronic Active | |
Mineralization | 1 |
Thrombosis | |
Alveolar Epithelium, Hyperplasia | 2 |
Mediastinum, Mineralization | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Atrophy | 4 |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accumulation, Hyaline Droplet | |
Infiltration Cellular, Mononuclear | |
Cell | 1 1 2 1 2 1 1 1 1 1 3 1 1 2 2 1 1 1 1 1 1 1|
Inflammation, Chronic Active | 2 |
Mineralization | 1 1 |
Nephropathy | 2 2 3 2 1 1 1 1 1 1 1|
Cortex, Cyst | 3 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mononuclear | |
Cell | 1 1 1 1 2 2 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 3| 5| 7| 7| 7| 7| 7| 7| 4| 2| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 5| 3| 3| 7| 6| 3| 3| 3| 1| 2| 3| 0| 8| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| |
| 1| 6| 2| 2| 4| 8| 1| 2| 1| 1| 2| 1| 5| 9| 1| 1| 2| 2| 1| 2| 1| 0| 1| 0| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
1.5 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | | 1 4.0|
Epithelium, Inflammation, Suppurative| | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 | 1 3.0|
Basophilic Focus | X | 7 |
Clear Cell Focus | X | 6 |
Eosinophilic Focus | X | 3 |
Hematopoietic Cell Proliferation | | 2 1.5|
Hepatodiaphragmatic Nodule | | 1 |
Infiltration Cellular, Mononuclear | | |
Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1| 36 1.0|
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 36 1.0|
Mixed Cell Focus | X | 1 |
Necrosis | 2 | 2 2.0|
Pigmentation | 1 1 1| 12 1.0|
Tension Lipidosis | X X| 3 |
Hepatocyte, Vacuolization Cytoplasmic| 2 1 1 4 2 | 9 1.8|
__________________________________________________________________________|____________|
Mesentery | + + + + + + | 11 |
Fibrosis | 2 2 3 | 7 2.1|
Hemorrhage | | 1 4.0|
Inflammation, Chronic Active | 3 2 3 | 6 2.5|
Mineralization | 2 2 2 | 7 2.1|
Fat, Necrosis | 4 4 4 | 7 4.0|
__________________________________________________________________________|____________|
Oral Mucosa | + + + | 5 |
Gingival, Foreign Body | X X X | 5 |
Gingival, Inflammation, Chronic | | |
Active | 2 2 2 | 5 1.8|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Mononuclear | | |
Cell | 2 2 1 1 1 2 1 2 1 1 1 1| 29 1.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 3| 5| 7| 7| 7| 7| 7| 7| 4| 2| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 5| 3| 3| 7| 6| 3| 3| 3| 1| 2| 3| 0| 8| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| |
| 1| 6| 2| 2| 4| 8| 1| 2| 1| 1| 2| 1| 5| 9| 1| 1| 2| 2| 1| 2| 1| 0| 1| 0| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
1.5 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis | | 1 4.0|
Epithelium, Hyperplasia | | 2 2.0|
Epithelium, Inflammation, Chronic | | |
Active | 2 | 2 1.5|
Epithelium, Ulcer | 4 | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectopic Tissue | 2 | 1 2.0|
Mineralization | 1 | 1 1.0|
Epithelium, Dysplasia | 3 | 1 3.0|
Glands, Ectasia | 1 1 1 1 | 9 1.1|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Valve, Inflammation, Chronic Active | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | | 1 1.0|
Infiltration Cellular, Mononuclear | | |
Cell | 1 | 1 1.0|
Capsule, Hyperplasia | 2 2 2 2 1 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 48 1.9|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 37 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | M + M + + + M + + + + + M M + + + M + M + + M M +| 39 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Angiectasis | 1 1 | 3 1.7|
Pars Distalis, Hemorrhage | 4 | 1 4.0|
Pars Distalis, Hyperplasia | 1 2 2 1 1 2 2| 12 1.8|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 3 | 1 3.0|
Follicle, Cyst | 2 | 3 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 3| 5| 7| 7| 7| 7| 7| 7| 4| 2| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 5| 3| 3| 7| 6| 3| 3| 3| 1| 2| 3| 0| 8| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| |
| 1| 6| 2| 2| 4| 8| 1| 2| 1| 1| 2| 1| 5| 9| 1| 1| 2| 2| 1| 2| 1| 0| 1| 0| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
1.5 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Mononuclear | | |
Cell | 1 | 2 1.0|
Inflammation, Chronic Active | 2 | 1 2.0|
Pigmentation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 3.0|
Cyst | 2 2 2 4 2 2 2 | 14 2.6|
Hemorrhage | 4 | 1 4.0|
Mineralization | 2 2 2 | 3 2.0|
Pigmentation | 2 2 1 1 2 2 1 | 16 1.8|
Thrombosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrometra | 3 4 4 3 4 3 4 3 4 4 4 3 | 28 3.2|
Inflammation, Suppurative | 3 | 1 3.0|
Pigmentation | | 1 2.0|
Endometrium, Hyperplasia, Cystic | 2 2 2 1 2 1 2 2 1 1 2 | 24 1.9|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 4 | 2 4.0|
Myelofibrosis | 2 3 | 3 2.3|
__________________________________________________________________________|____________|
Lymph Node | + + + | 6 |
Lumbar, Ectasia | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + M + + + + + + +| 49 |
Hyperplasia, Lymphoid | 4 4 | 4 3.8|
Pigmentation | 1 2 2 2 2 2 | 16 1.6|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hemorrhage | | 1 2.0|
Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 2 3 2 3 2 2 2 3 2| 22 2.5|
Hyperplasia, Lymphoid | 2 2 2 | 3 2.0|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + M + + + + M + + M + + + M| 43 |
Cyst | 2 2 2 1 1 2 2 1 2 | 17 1.9|
Ectopic Parathyroid Gland | | 1 2.0|
Thymocyte, Necrosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 3| 5| 7| 7| 7| 7| 7| 7| 4| 2| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 5| 3| 3| 7| 6| 3| 3| 3| 1| 2| 3| 0| 8| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| |
| 1| 6| 2| 2| 4| 8| 1| 2| 1| 1| 2| 1| 5| 9| 1| 1| 2| 2| 1| 2| 1| 0| 1| 0| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
1.5 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Cystic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 1 2.0|
Inflammation, Chronic Active | | 1 1.0|
Meninges, Hemorrhage | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 3.0|
Inflammation, Chronic Active | 1 | 1 1.0|
Mineralization | | 1 1.0|
Thrombosis | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
Mediastinum, Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Atrophy | | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accumulation, Hyaline Droplet | 3 | 1 3.0|
Infiltration Cellular, Mononuclear | | |
Cell | 1 1 1 2 1 1 1 1 2 1 1 1 2 1 1 1 1 1 1 1| 42 1.2|
Inflammation, Chronic Active | | 1 2.0|
Mineralization | 1 1 1| 5 1.0|
Nephropathy | 2 1 1 1 1 1 2 1| 19 1.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 3| 5| 7| 7| 7| 7| 7| 7| 4| 2| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 5| 3| 3| 7| 6| 3| 3| 3| 1| 2| 3| 0| 8| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| |
| 1| 6| 2| 2| 4| 8| 1| 2| 1| 1| 2| 1| 5| 9| 1| 1| 2| 2| 1| 2| 1| 0| 1| 0| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
1.5 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Cortex, Cyst | 3 | 3 2.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Mononuclear | | |
Cell | 1 1 2 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1| 31 1.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 8| 3| 3| 3| 3| 0| 3| 3| 3| 3| 1| 3| 3| 3|
| 1| 0| 2| 2| 1| 2| 2| 2| 1| 1| 3| 9| 3| 2| 1| 2| 2| 0| 2| 1| 1| 6| 2| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
3 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mononuclear | |
Cell | 1|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Squamous | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + A + + + + + + + +|
Angiectasis | |
Basophilic Focus | X |
Clear Cell Focus | X X X |
Eosinophilic Focus | X X X X X |
Hematopoietic Cell Proliferation | 1 1 1 1 2 |
Infiltration Cellular, Mononuclear | |
Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1|
Inflammation, Chronic Active | 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 |
Mineralization | 4 |
Mixed Cell Focus | X|
Necrosis | |
Pigmentation | 1 1 1 1 2 |
Hepatocyte, Vacuolization Cytoplasmic| 2 |
__________________________________________________________________________|
Mesentery | + + + + + + + + |
Fibrosis | 3 2 2 2 |
Inflammation, Chronic Active | 1 2 2 1 |
Mineralization | 1 1 2 2 2 1 1 |
Pigmentation | 2 |
Thrombosis | 4 |
Fat, Necrosis | 4 4 4 4 4 |
__________________________________________________________________________|
Oral Mucosa | + |
Gingival, Foreign Body | |
Gingival, Inflammation, Chronic | |
Active | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mononuclear | |
Cell | 2 2 1 1 1 2 1 1 1 1 2 1 2 1 1 1 2|
Inflammation, Chronic Active | |
Mineralization | 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 8| 3| 3| 3| 3| 0| 3| 3| 3| 3| 1| 3| 3| 3|
| 1| 0| 2| 2| 1| 2| 2| 2| 1| 1| 3| 9| 3| 2| 1| 2| 2| 0| 2| 1| 1| 6| 2| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
3 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Epithelium, Hyperplasia | |
Epithelium, Inflammation, Chronic | |
Active | |
Epithelium, Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Ectasia | 1 1 1 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypertrophy | |
Capsule, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 3 2 2 2 1 2 2 2|
Zona Reticularis, Hyperplasia | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Parathyroid Gland | M + M M + M + + M + M M + M M M + + + + + + M M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Cyst | 2 |
Pars Distalis, Hyperplasia | 2 2 2 |
Pars Distalis, Pigmentation | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Thymus | |
Follicle, Cyst | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mononuclear | |
Cell | 1 |
Duct, Cyst | 3 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 2 2 4 2 2 4 4 2|
Hemorrhage | 4 3 4 |
Mineralization | 1 1 |
Pigmentation | 2 1 2 2 2 2 1|
Thrombosis | 4 3 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 8| 3| 3| 3| 3| 0| 3| 3| 3| 3| 1| 3| 3| 3|
| 1| 0| 2| 2| 1| 2| 2| 2| 1| 1| 3| 9| 3| 2| 1| 2| 2| 0| 2| 1| 1| 6| 2| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
3 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Hydrometra | 3 2 4 3 2 2 4 3 2 2 2 2|
Endometrium, Hyperplasia, Cystic | 3 2 1 2 2 2 1 2 3 2 1 1 2 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 4 |
__________________________________________________________________________|
Lymph Node | + + + + |
Lumbar, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + M M + + M + + + + + + +|
Hyperplasia, Lymphoid | 2 4 4 |
Pigmentation | 2 2 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + M + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + A + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 2 2 4 3 3 2 2 |
Hyperplasia, Lymphoid | |
Mineralization | 4 |
Pigmentation | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + M M + +|
Cyst | 2 2 2 2 1 2 2 2 2 2|
Ectopic Parathyroid Gland | |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
Demyelination | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Mineralization | |
Thrombosis | 2 |
Alveolar Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 8| 3| 3| 3| 3| 0| 3| 3| 3| 3| 1| 3| 3| 3|
| 1| 0| 2| 2| 1| 2| 2| 2| 1| 1| 3| 9| 3| 2| 1| 2| 2| 0| 2| 1| 1| 6| 2| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
3 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + A + + + + + + + +|
Hydronephrosis | 3 |
Infiltration Cellular, Mononuclear | |
Cell | 1 1 1 1 1 1 2 1 1 1 1 1 1 2 1 1 1 1 1|
Mineralization | 1 1 |
Nephropathy | 1 1 1 1 1 1 1|
Pigmentation | 2 |
Cortex, Cyst | |
Renal Tubule, Casts Protein | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mononuclear | |
Cell | 1 1 1 1 1 1 1 1 2 1 1|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| |
| 9| 1| 0| 2| 1| 2| 2| 1| 2| 1| 1| 1| 0| 0| 2| 1| 0| 2| 1| 0| 0| 1| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
3 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Mononuclear | | |
Cell | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Metaplasia, Squamous | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 2 | 1 2.0|
Basophilic Focus | X | 2 |
Clear Cell Focus | X X X | 6 |
Eosinophilic Focus | X X X X X X | 11 |
Hematopoietic Cell Proliferation | 1 | 6 1.2|
Infiltration Cellular, Mononuclear | | |
Cell | 1 1 1 2 1 1 2 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1| 40 1.1|
Inflammation, Chronic Active | 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1| 41 1.1|
Mineralization | | 1 4.0|
Mixed Cell Focus | X X | 3 |
Necrosis | 2 2 | 2 2.0|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 | 17 1.1|
Hepatocyte, Vacuolization Cytoplasmic| 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + | 15 |
Fibrosis | 3 2 2 3 3 3 | 10 2.5|
Inflammation, Chronic Active | 3 3 2 2 | 8 2.0|
Mineralization | 2 3 1 2 3 | 12 1.8|
Pigmentation | | 1 2.0|
Thrombosis | | 1 4.0|
Fat, Necrosis | 4 4 4 4 4 4 | 11 4.0|
__________________________________________________________________________|____________|
Oral Mucosa | + | 2 |
Gingival, Foreign Body | X | 1 |
Gingival, Inflammation, Chronic | | |
Active | 2 | 2 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3| 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| |
| 9| 1| 0| 2| 1| 2| 2| 1| 2| 1| 1| 1| 0| 0| 2| 1| 0| 2| 1| 0| 0| 1| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
3 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Infiltration Cellular, Mononuclear | | |
Cell | 1 1 1 1 2 1 1 1 1 1 1 1 1 2 1 | 32 1.3|
Inflammation, Chronic Active | 1 1 | 2 1.0|
Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Hyperplasia | 2 | 1 2.0|
Epithelium, Inflammation, Chronic | | |
Active | 2 1 | 2 1.5|
Epithelium, Ulcer | 4 | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Glands, Ectasia | 1 1 1 1 1 2 | 10 1.1|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hypertrophy | 2 | 1 2.0|
Capsule, Hyperplasia | 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 50 2.0|
Zona Reticularis, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 40 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + M + M M + + M| 34 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Angiectasis | 2 2 2 1 1| 6 1.7|
Pars Distalis, Cyst | 1 | 2 1.5|
Pars Distalis, Hyperplasia | 2 2 2 2 1 2 2| 10 1.9|
Pars Distalis, Pigmentation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectopic Thymus | 2 | 1 2.0|
Follicle, Cyst | 2 3 | 3 2.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| |
| 9| 1| 0| 2| 1| 2| 2| 1| 2| 1| 1| 1| 0| 0| 2| 1| 0| 2| 1| 0| 0| 1| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
3 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Infiltration Cellular, Mononuclear | | |
Cell | 1 1 | 3 1.0|
Duct, Cyst | | 2 2.5|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 4 2 2 2 2 2 2 2 | 18 2.4|
Hemorrhage | 4 | 4 3.8|
Mineralization | | 2 1.0|
Pigmentation | 2 1 2 2 | 11 1.7|
Thrombosis | | 3 3.7|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrometra | 2 4 2 4 3 4 4 3 4 2 2 2 4 4 3 2 4 3 3 | 31 2.9|
Endometrium, Hyperplasia, Cystic | 2 2 2 2 2 2 1 2 2 2 | 24 1.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 4 4 | 4 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + | 8 |
Lumbar, Hyperplasia, Lymphoid | 4 | 1 4.0|
Mediastinal, Hyperplasia, Lymphoid | 2 3 | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + M + + + + + + + + + + + + + + + + + +| 46 |
Hyperplasia, Lymphoid | | 3 3.3|
Pigmentation | 1 2 2 2| 9 1.9|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + M M + + +| 47 |
Hyperplasia, Lymphoid | 4 | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 3 2 3 3 2 3 | 15 2.5|
Hyperplasia, Lymphoid | 3 | 1 3.0|
Mineralization | | 1 4.0|
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | M + + + + + + + + + + + + + + + + + + M + + + + +| 46 |
Cyst | 2 3 1 2 2 2 2 2 2 2 2 2 2| 23 2.0|
Ectopic Parathyroid Gland | 1 | 1 1.0|
Hyperplasia, Lymphoid | 4 4 | 2 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| |
| 9| 1| 0| 2| 1| 2| 2| 1| 2| 1| 1| 1| 0| 0| 2| 1| 0| 2| 1| 0| 0| 1| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
3 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
__________________________________________________________________________|____________|
Spinal Cord | + + | 2 |
Demyelination | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 1 1 2 | 3 1.3|
Mineralization | 1 1 | 2 1.0|
Thrombosis | | 1 2.0|
Alveolar Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hydronephrosis | | 1 3.0|
Infiltration Cellular, Mononuclear | | |
Cell | 1 1 1 3 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 44 1.1|
Mineralization | 1 1 1| 5 1.0|
Nephropathy | 2 1 3 1 1 1 1 1 1 1 1 1 1 2 1 | 22 1.2|
Pigmentation | | 1 2.0|
Cortex, Cyst | 2 | 1 2.0|
Renal Tubule, Casts Protein | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Mononuclear | | |
Cell | 1 1 1 1 1 1 2 1 2 1 1 1 1 1 1 1 2 1| 29 1.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 7| 6| 7| 7| 7| 7| 6| 5| 7| 4| 4| 4| 4| 4|
DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 0| 3| 4| 3| 3| 3| 3| 4| 8| 3| 8| 8| 8| 8| 8|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 8| 1| 1| 1| 2| 2| 2| 1| 1| 1| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
6 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | X |
Eosinophilic Focus | X |
Hematopoietic Cell Proliferation | 1 |
Infiltration Cellular, Mononuclear | |
Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Mineralization | |
Necrosis | |
Pigmentation | 1 1 |
Hepatocyte, Vacuolization Cytoplasmic| 1 1 1 1 2 1 1 1 1|
__________________________________________________________________________|
Mesentery | + |
Fibrosis | 2 |
Mineralization | |
Fat, Necrosis | 4 |
__________________________________________________________________________|
Oral Mucosa | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + M + + + + + + + A + + + + + +|
Infiltration Cellular, Mononuclear | |
Cell | 1 2 |
Acinus, Hyperplasia | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mononuclear | |
Cell | 1 1 1 1 2 1 1 1 1 1 1 1 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | |
Epithelium, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Glands, Ectasia | 1 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 7| 6| 7| 7| 7| 7| 6| 5| 7| 4| 4| 4| 4| 4|
DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 0| 3| 4| 3| 3| 3| 3| 4| 8| 3| 8| 8| 8| 8| 8|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 8| 1| 1| 1| 2| 2| 2| 1| 1| 1| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
6 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Hematopoietic Cell Proliferation | |
Capsule, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 1 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + A + + + + + +|
Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M + + + M + + M + + M + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + I + + + + + +|
Pars Distalis, Angiectasis | 2 2 |
Pars Distalis, Cyst | 2 1 |
Pars Distalis, Hyperplasia | 2 2 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mononuclear | |
Cell | 1 |
Follicle, Cyst | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mononuclear | |
Cell | 1 |
Inflammation, Chronic Active | |
Duct, Cyst | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + I + + + + + + + + + + + +|
Cyst | 2 3 2 |
Hemorrhage | |
Inflammation, Suppurative | |
Mineralization | 2 |
Pigmentation | 1 1 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 |
Hemorrhage | |
Hydrometra | 2 2 2 2 2 2 4 3 3 4 2 |
Endometrium, Hyperplasia, Cystic | 2 2 2 2 3 2 2 2 2 2 2 1 1 1|
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 7| 6| 7| 7| 7| 7| 6| 5| 7| 4| 4| 4| 4| 4|
DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 0| 3| 4| 3| 3| 3| 3| 4| 8| 3| 8| 8| 8| 8| 8|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 8| 1| 1| 1| 2| 2| 2| 1| 1| 1| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
6 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node | |
Lumbar, Ectasia | |
Mediastinal, Inflammation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + M + +|
Hyperplasia, Lymphoid | |
Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + M + + + + + + + A + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + A + + + + + +|
Hematopoietic Cell Proliferation | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 1 2 2 2 2 2|
Thymocyte, Necrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Mineralization | 1 |
Necrosis | |
Alveolus, Infiltration Cellular, | |
Histiocyte | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Atrophy | |
Anterior Chamber, Infiltration | |
Cellular, Polymorphonuclear | 3 |
Cornea, Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 7| 6| 7| 7| 7| 7| 6| 5| 7| 4| 4| 4| 4| 4|
DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 0| 3| 4| 3| 3| 3| 3| 4| 8| 3| 8| 8| 8| 8| 8|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 8| 1| 1| 1| 2| 2| 2| 1| 1| 1| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
6 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mononuclear | |
Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Mineralization | 1 1 |
Nephropathy | 1 1 1 1 |
Cortex, Cyst | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mononuclear | |
Cell | 1 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 2| 7| 3| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 1| 3| 3| 0| 3| 3| 3| 9| 1| 3| 4| |
| 2| 2| 1| 0| 2| 1| 2| 1| 1| 0| 2| 1| 3| 2| 4| 0| 1| 3| 1| 2| 1| 4| 2| 1| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
6 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + M + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Peyer's Patch, Hyperplasia, Lymphoid | 3 | 2 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X | 2 |
Clear Cell Focus | | 1 |
Eosinophilic Focus | X X | 3 |
Hematopoietic Cell Proliferation | 1 | 2 1.0|
Infiltration Cellular, Mononuclear | | |
Cell | 1 1 1 1 1 2 1 1 1 2 1 1 1 1 1 | 30 1.1|
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 2 1 1 1 1 2 1 2 1 1 1 1 | 38 1.1|
Mineralization | 1| 1 1.0|
Necrosis | 3| 1 3.0|
Pigmentation | 1 1 1 1 1 | 7 1.0|
Hepatocyte, Vacuolization Cytoplasmic| 2 2 2 2 1 2 1 2 1 | 18 1.4|
__________________________________________________________________________|____________|
Mesentery | + + + | 4 |
Fibrosis | 2 | 2 2.0|
Mineralization | 2 | 1 2.0|
Fat, Necrosis | 4 4 | 3 4.0|
__________________________________________________________________________|____________|
Oral Mucosa | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Infiltration Cellular, Mononuclear | | |
Cell | | 2 1.5|
Acinus, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + M + + +| 49 |
Infiltration Cellular, Mononuclear | | |
Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 27 1.0|
Inflammation, Chronic Active | 4 | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Hyperplasia | 3 | 1 3.0|
Epithelium, Inflammation, Chronic | | |
Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 2| 7| 3| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 1| 3| 3| 0| 3| 3| 3| 9| 1| 3| 4| |
| 2| 2| 1| 0| 2| 1| 2| 1| 1| 0| 2| 1| 3| 2| 4| 0| 1| 3| 1| 2| 1| 4| 2| 1| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
6 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Mineralization | 1| 1 1.0|
Glands, Ectasia | 1 | 3 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 2| 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 2 1 | 2 1.5|
Hematopoietic Cell Proliferation | 1 | 1 1.0|
Capsule, Hyperplasia | 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 1| 50 1.9|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2 | 33 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + M M + + + + M + M + + + + + + M + + + + + + + M| 40 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Angiectasis | | 2 2.0|
Pars Distalis, Cyst | | 2 1.5|
Pars Distalis, Hyperplasia | 3 2 2 3 2 2 2 2 | 11 2.1|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Mononuclear | | |
Cell | | 1 1.0|
Follicle, Cyst | 2 2 2 | 4 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Peritoneum | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + M + + + + + + +| 49 |
Infiltration Cellular, Mononuclear | | |
Cell | | 1 1.0|
Inflammation, Chronic Active | 2 | 1 2.0|
Duct, Cyst | 2 3 | 2 2.5|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 3 2 2 2 3 3 4| 10 2.6|
Hemorrhage | 2| 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 2| 7| 3| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 1| 3| 3| 0| 3| 3| 3| 9| 1| 3| 4| |
| 2| 2| 1| 0| 2| 1| 2| 1| 1| 0| 2| 1| 3| 2| 4| 0| 1| 3| 1| 2| 1| 4| 2| 1| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
6 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Suppurative | 2| 1 2.0|
Mineralization | | 1 2.0|
Pigmentation | 1 2 2 2 | 6 1.5|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 4.0|
Hemorrhage | 2 | 1 2.0|
Hydrometra | 3 3 4 2 4 2 4 4 4 | 20 2.9|
Endometrium, Hyperplasia, Cystic | 1 2 2 1 2 1 2 2 3 3 2 2 2 1 2 1 1 1| 32 1.8|
__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + | 5 |
Lumbar, Ectasia | 4 | 1 4.0|
Mediastinal, Inflammation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + M + + + + + + + + + M + + +| 47 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
Pigmentation | 2 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + M + + + + + M + + + + + +| 46 |
Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 2 2 2 3 2 3 3 2 4| 10 2.6|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + M + + + + + + M| 48 |
Cyst | 2 2 2 2 2 2 2 2 2 2 1 | 19 1.9|
Thymocyte, Necrosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 2| 7| 3| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 1| 3| 3| 0| 3| 3| 3| 9| 1| 3| 4| |
| 2| 2| 1| 0| 2| 1| 2| 1| 1| 0| 2| 1| 3| 2| 4| 0| 1| 3| 1| 2| 1| 4| 2| 1| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
6 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | 2 | 1 2.0|
Mineralization | 1 | 2 1.0|
Necrosis | 3 | 1 3.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 3 | 2 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 4 |
Atrophy | 4 | 1 4.0|
Anterior Chamber, Infiltration | | |
Cellular, Polymorphonuclear | | 1 3.0|
Cornea, Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Mononuclear | | |
Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 35 1.0|
Mineralization | 1 1 1 2| 6 1.2|
Nephropathy | 1 1 1 1 1 | 9 1.0|
Cortex, Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Mononuclear | | |
Cell | 1 1 1 1 1 1 1 2 1 1 1 1 | 22 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 6| 7| 6| 7| 0| 7| 7|
DAY ON TEST | 3| 3| 2| 7| 9| 3| 0| 0| 2| 3| 2| 3| 3| 3| 3| 0| 7| 2| 3| 3| 5| 1| 7| 2| 3|
| 0| 1| 9| 0| 4| 1| 9| 0| 9| 0| 9| 0| 1| 0| 0| 1| 7| 9| 8| 0| 0| 2| 3| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + M + + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Clear Cell Focus | X X X X|
Eosinophilic Focus | X X X X X X X X X |
Hepatodiaphragmatic Nodule | X |
Infiltration Cellular, Mast Cell | |
Infiltration Cellular, Mononuclear | |
Cell | 3 1 1 1 1 |
Inflammation, Chronic Active | 1 1 1 1 3 2 1 2 1 |
Malformation | |
Necrosis | 2 3 3 |
Pigmentation | 2 1 |
Tension Lipidosis | |
Hepatocyte, Vacuolization Cytoplasmic| 2 1 1 2|
__________________________________________________________________________|
Mesentery | + |
Fibrosis | |
Inflammation, Chronic Active | |
Thrombosis | 4 |
Fat, Necrosis | |
__________________________________________________________________________|
Oral Mucosa | + + + + + + + + + + + + + + |
Gingival, Foreign Body | X X X X X X X X X X X X X |
Gingival, Inflammation, Acute | 1 1 1 1 |
Gingival, Inflammation, Chronic | |
Active | 1 2 1 2 2 2 2 1 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mononuclear | |
Cell | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma | 2 |
Infiltration Cellular, Mononuclear | |
Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Inflammation, Chronic | 1 |
Mineralization | 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 6| 7| 6| 7| 0| 7| 7|
DAY ON TEST | 3| 3| 2| 7| 9| 3| 0| 0| 2| 3| 2| 3| 3| 3| 3| 0| 7| 2| 3| 3| 5| 1| 7| 2| 3|
| 0| 1| 9| 0| 4| 1| 9| 0| 9| 0| 9| 0| 1| 0| 0| 1| 7| 9| 8| 0| 0| 2| 3| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Epithelium, Inflammation, Chronic | |
Active | 2 |
Epithelium, Ulcer | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
Epithelium, Erosion | 2 |
Epithelium, Inflammation, Chronic | |
Active | |
Glands, Ectasia | 1 1 1 1 1 1|
__________________________________________________________________________|
Tooth | + |
Malformation | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + I + +|
Inflammation, Chronic Active | 3 |
Mineralization | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 1 |
Hyperplasia | 3 1 1 2 3 3 2|
Hypertrophy | 3 3 2 1 1 3 1 2 1 2 1 1 2|
Metaplasia, Osseous | 3 |
Capsule, Hyperplasia | 2 2 1 1 1 1 1 2 2 2 2 1 1 1 1 1 1 1|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 3 2 2 2 2 2 2 3 3 2 2 3 3 2 2 2 2 2 2 3|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + M + M + M + + + + M + + +|
Cyst | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + I + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | 3 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Granuloma Sperm | 3 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 6| 7| 6| 7| 0| 7| 7|
DAY ON TEST | 3| 3| 2| 7| 9| 3| 0| 0| 2| 3| 2| 3| 3| 3| 3| 0| 7| 2| 3| 3| 5| 1| 7| 2| 3|
| 0| 1| 9| 0| 4| 1| 9| 0| 9| 0| 9| 0| 1| 0| 0| 1| 7| 9| 8| 0| 0| 2| 3| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Infiltration Cellular, Mononuclear | |
Cell | 1 1 1 2 1 1 1 1 1 1 |
Inflammation, Chronic Active | |
Mineralization | 1 |
__________________________________________________________________________|
Penis | + |
Hemorrhage | 3 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Infiltration Cellular, Mononuclear | |
Cell | 1 1 2 2 1 2 2 1|
Inflammation, Chronic Active | 2 4 1 4 |
Duct, Cyst | 2 2 3 3 3 2 3 2|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Infiltration Cellular, Mononuclear | |
Cell | 1 1 1 1 1 1 1 1 2 1 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
Germinal Epithelium, Atrophy | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + M + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 |
Hemorrhage | 3 |
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Plasma Cell | |
Inflammation, Granulomatous | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 2 4 2|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Thymus | M + + M + + + + + + + + + M + + M + M + + + + +|
Cyst | 2 2 2 2 1 |
Ectopic Parathyroid Gland | 1 |
Ectopic Thyroid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 6| 7| 6| 7| 0| 7| 7|
DAY ON TEST | 3| 3| 2| 7| 9| 3| 0| 0| 2| 3| 2| 3| 3| 3| 3| 0| 7| 2| 3| 3| 5| 1| 7| 2| 3|
| 0| 1| 9| 0| 4| 1| 9| 0| 9| 0| 9| 0| 1| 0| 0| 1| 7| 9| 8| 0| 0| 2| 3| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mononuclear | |
Cell | 2 |
Inflammation, Chronic Active | 2 |
Mineralization | 1 1|
Thrombosis | 2 4 |
Alveolar Epithelium, Hyperplasia | 2 4 |
Alveolus, Infiltration Cellular, | |
Histiocyte | |
Bronchiole, Foreign Body | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X |
Inflammation, Chronic Active | 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cornea, Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Harderian Gland | + + |
Infiltration Cellular, Mononuclear | |
Cell | 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 3 2 |
Infiltration Cellular, Mononuclear | |
Cell | 1 1 1 1 1 1 1 1 1 |
Inflammation, Chronic Active | |
Metaplasia, Osseous | 3 |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Nephropathy | 1 1 2 1 1 2 1 1 2 2 2 2 1 3 1 2 1 1|
Cortex, Cyst | 2 2 2 2 2 1|
Renal Tubule, Hyperplasia | 2 2 2 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 6| 7| 6| 7| 0| 7| 7|
DAY ON TEST | 3| 3| 2| 7| 9| 3| 0| 0| 2| 3| 2| 3| 3| 3| 3| 0| 7| 2| 3| 3| 5| 1| 7| 2| 3|
| 0| 1| 9| 0| 4| 1| 9| 0| 9| 0| 9| 0| 1| 0| 0| 1| 7| 9| 8| 0| 0| 2| 3| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Necrosis | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mononuclear | |
Cell | 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
__________________________________________________________________________________________________________________________________
| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| |
DAY ON TEST | 3| 8| 6| 9| 3| 2| 3| 3| 3| 2| 9| 3| 3| 3| 3| 3| 2| 2| 3| 2| 1| 3| 3| 3| 2| |
| 1| 3| 3| 4| 1| 9| 0| 0| 1| 9| 4| 0| 1| 1| 0| 1| 9| 9| 0| 9| 3| 1| 0| 1| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + M + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | | 1 2.0|
Clear Cell Focus | X X X | 7 |
Eosinophilic Focus | X X X X X X X | 16 |
Hepatodiaphragmatic Nodule | | 1 |
Infiltration Cellular, Mast Cell | 2 | 1 2.0|
Infiltration Cellular, Mononuclear | | |
Cell | 1 1 1 1 | 9 1.2|
Inflammation, Chronic Active | 1 2 1 1 2 1 1 1 1 1 1 1 1 | 22 1.3|
Malformation | 2 | 1 2.0|
Necrosis | 2 2 2 | 6 2.3|
Pigmentation | 2 | 3 1.7|
Tension Lipidosis | X | 1 |
Hepatocyte, Vacuolization Cytoplasmic| 1 1 | 6 1.3|
__________________________________________________________________________|____________|
Mesentery | + + | 3 |
Fibrosis | 2 | 1 2.0|
Inflammation, Chronic Active | 2 | 1 2.0|
Thrombosis | | 1 4.0|
Fat, Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Oral Mucosa | + + + + + + + + + + + + + + + + + | 31 |
Gingival, Foreign Body | X X X X X X X X X X X X X X | 27 |
Gingival, Inflammation, Acute | 1 1 1 1 1 | 9 1.0|
Gingival, Inflammation, Chronic | | |
Active | 2 1 2 1 2 2 1 2 2 2 | 19 1.7|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Infiltration Cellular, Mononuclear | | |
Cell | 1 | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Granuloma | | 1 2.0|
Infiltration Cellular, Mononuclear | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
__________________________________________________________________________________________________________________________________
| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| |
DAY ON TEST | 3| 8| 6| 9| 3| 2| 3| 3| 3| 2| 9| 3| 3| 3| 3| 3| 2| 2| 3| 2| 1| 3| 3| 3| 2| |
| 1| 3| 3| 4| 1| 9| 0| 0| 1| 9| 4| 0| 1| 1| 0| 1| 9| 9| 0| 9| 3| 1| 0| 1| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Cell | 1 2 1 1 1 1 1 1 1 | 22 1.0|
Inflammation, Chronic | | 1 1.0|
Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Epithelium, Hyperplasia | 3 | 2 2.5|
Epithelium, Inflammation, Chronic | | |
Active | 3 | 2 2.5|
Epithelium, Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Ulcer | 4 | 1 4.0|
Epithelium, Erosion | | 1 2.0|
Epithelium, Inflammation, Chronic | | |
Active | 4 | 1 4.0|
Glands, Ectasia | 1 1 2 1 2 1 1 1 1 1 1 | 17 1.1|
__________________________________________________________________________|____________|
Tooth | + + + + + | 6 |
Malformation | X X X X X | 6 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Chronic Active | 1 | 2 2.0|
Mineralization | 1 | 2 1.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Degeneration, Fatty | | 1 1.0|
Hyperplasia | 1 3 3 2 2 2 1 | 14 2.1|
Hypertrophy | 3 1 2 1 3 2 2 1 1 1 1 2 2| 26 1.7|
Metaplasia, Osseous | | 1 3.0|
Capsule, Hyperplasia | 1 1 1 2 1 2 2 1 2 1 2 1 1 2 2 1 2 3 2 1 1 3 1| 41 1.5|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 2 2 2 2 2 2 2 2 3 2 3 3 2 2 2 2 2 2 2 3 2 2 2 3| 47 2.2|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + + + + + M + + + + + + + + + M + + + +| 42 |
Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Pars Distalis, Cyst | 2 | 1 2.0|
Pars Distalis, Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
__________________________________________________________________________________________________________________________________
| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| |
DAY ON TEST | 3| 8| 6| 9| 3| 2| 3| 3| 3| 2| 9| 3| 3| 3| 3| 3| 2| 2| 3| 2| 1| 3| 3| 3| 2| |
| 1| 3| 3| 4| 1| 9| 0| 0| 1| 9| 4| 0| 1| 1| 0| 1| 9| 9| 0| 9| 3| 1| 0| 1| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Follicle, Cyst | | 2 2.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | | 1 3.0|
Granuloma Sperm | 3 | 2 3.0|
Infiltration Cellular, Mononuclear | | |
Cell | 1 1 1 2 1 1 1 | 17 1.1|
Inflammation, Chronic Active | 3 | 1 3.0|
Mineralization | 1 | 2 1.0|
__________________________________________________________________________|____________|
Penis | | 1 |
Hemorrhage | | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | | 1 3.0|
Infiltration Cellular, Mononuclear | | |
Cell | 1 1 2 1 2 2 2 1 2 1 1 2 1 | 21 1.5|
Inflammation, Chronic Active | 2 1 1 3 2 2 4 2 3 | 13 2.4|
Duct, Cyst | 3 2 2 2 2 2 2 2 3 3 | 18 2.4|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | | 1 3.0|
Infiltration Cellular, Mononuclear | | |
Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 25 1.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Mineralization | 1 | 2 1.5|
Germinal Epithelium, Atrophy | | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lymph Node | + +| 3 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + M + + + + + + I + + + + + +| 46 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + M M + + + + + + + + + + + + + + + + + + + + +| 46 |
Hematopoietic Cell Proliferation | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
__________________________________________________________________________________________________________________________________
| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| |
DAY ON TEST | 3| 8| 6| 9| 3| 2| 3| 3| 3| 2| 9| 3| 3| 3| 3| 3| 2| 2| 3| 2| 1| 3| 3| 3| 2| |
| 1| 3| 3| 4| 1| 9| 0| 0| 1| 9| 4| 0| 1| 1| 0| 1| 9| 9| 0| 9| 3| 1| 0| 1| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hemorrhage | | 1 3.0|
Hyperplasia, Lymphoid | | 1 3.0|
Hyperplasia, Plasma Cell | 3 | 1 3.0|
Inflammation, Granulomatous | 4 | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 2 4 3 3 3 2 2| 12 2.8|
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + M M + + + + + + + + + + M M + + + + + + + + +| 40 |
Cyst | 1 1 2 2 1 1 2 1 2 2 2 | 16 1.6|
Ectopic Parathyroid Gland | 2 1 | 3 1.3|
Ectopic Thyroid | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Infiltration Cellular, Mononuclear | | |
Cell | | 1 2.0|
Inflammation, Chronic Active | 2 | 2 2.0|
Mineralization | 1 | 3 1.0|
Thrombosis | 1 | 3 2.3|
Alveolar Epithelium, Hyperplasia | 1 | 3 2.3|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 3 3 2 | 4 2.3|
Bronchiole, Foreign Body | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Foreign Body | X X | 3 |
Inflammation, Chronic Active | 4 | 2 3.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 | 4 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
__________________________________________________________________________________________________________________________________
| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| |
DAY ON TEST | 3| 8| 6| 9| 3| 2| 3| 3| 3| 2| 9| 3| 3| 3| 3| 3| 2| 2| 3| 2| 1| 3| 3| 3| 2| |
| 1| 3| 3| 4| 1| 9| 0| 0| 1| 9| 4| 0| 1| 1| 0| 1| 9| 9| 0| 9| 3| 1| 0| 1| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Cornea, Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 3 |
Infiltration Cellular, Mononuclear | | |
Cell | | 1 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Infarct | | 2 2.5|
Infiltration Cellular, Mononuclear | | |
Cell | 1 1 1 1 1 2 1 1 1 1 2 1 1 1 1 1 1 1 | 27 1.1|
Inflammation, Chronic Active | 1 | 1 1.0|
Metaplasia, Osseous | 2 | 2 2.5|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 43 1.0|
Nephropathy | 2 2 1 1 2 2 1 2 2 1 1 1 2 2 1 1 2 2 2 2 1 1 1 2 1| 43 1.5|
Cortex, Cyst | 2 2 2 1 3| 11 1.9|
Renal Tubule, Hyperplasia | 2 2 2 2 2 2 | 9 2.0|
Renal Tubule, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Infiltration Cellular, Mononuclear | | |
Cell | 1 1 1 1 1 1 | 12 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 2| 2| 2| 3| 3| 3| 3| 3| 3| 2| 2| 2| 6| 2| 3| 2| 2| 2| 3| 3| 1| 3| 3|
| 1| 1| 9| 9| 9| 1| 0| 1| 1| 1| 1| 5| 9| 9| 3| 9| 0| 9| 9| 9| 1| 0| 4| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
1.5 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Periesophageal Tissue, Inflammation, | |
Chronic Active | |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + M + + + + + + + + + + + +|
Hyperplasia | 3 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X |
Clear Cell Focus | X X X X X X |
Eosinophilic Focus | X X X X |
Infiltration Cellular, Mononuclear | |
Cell | 1 1 1 1 1 1 |
Inflammation, Chronic Active | 1 1 1 1 1 1|
Mixed Cell Focus | X X X X|
Necrosis | 2 3 2 2 |
Hepatocyte, Vacuolization Cytoplasmic| 2 1 1 2 1|
__________________________________________________________________________|
Mesentery | + + |
Fibrosis | 2 |
Inflammation, Chronic Active | |
Mineralization | |
Fat, Necrosis | 4 |
__________________________________________________________________________|
Oral Mucosa | + + + + + + + + + + + + + + +|
Gingival, Foreign Body | X X X X X X X X X X X X X X X|
Gingival, Inflammation, Acute | 1 2 1|
Gingival, Inflammation, Chronic | 1 |
Gingival, Inflammation, Chronic | |
Active | 1 1 1 1 2 2 1 2 2 1 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mononuclear | |
Cell | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mononuclear | |
Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Mineralization | 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | 2 2 |
Epithelium, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 2| 2| 2| 3| 3| 3| 3| 3| 3| 2| 2| 2| 6| 2| 3| 2| 2| 2| 3| 3| 1| 3| 3|
| 1| 1| 9| 9| 9| 1| 0| 1| 1| 1| 1| 5| 9| 9| 3| 9| 0| 9| 9| 9| 1| 0| 4| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
1.5 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Active | |
Epithelium, Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Mineralization | |
Epithelium, Hyperplasia | 2 |
Epithelium, Inflammation, Chronic | |
Active | |
Glands, Ectasia | 1 1 2 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 |
Artery, Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 1 1 2 2 2|
Hypertrophy | 1 2 2 2 2 2 3 1 3 2 1 3 2 1 2 2|
Inflammation, Suppurative | |
Capsule, Hyperplasia | 2 2 2 2 2 1 1 2 1 1 1 2 1 2 2 1 1 2 2 1 2|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2 3 3 2 2 2 3|
__________________________________________________________________________|
Parathyroid Gland | M M + + + + + + + + M + + + + + M + M + + + M + M|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mononuclear | |
Cell | 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mononuclear | |
Cell | 1 2 2 2 1 2 1 2 1 2 1 2 1 1 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 2| 2| 2| 3| 3| 3| 3| 3| 3| 2| 2| 2| 6| 2| 3| 2| 2| 2| 3| 3| 1| 3| 3|
| 1| 1| 9| 9| 9| 1| 0| 1| 1| 1| 1| 5| 9| 9| 3| 9| 0| 9| 9| 9| 1| 0| 4| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
1.5 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Chronic Active | 3 2 2 2 |
Duct, Cyst | 2 2 2 3 2 2 2 2 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mononuclear | |
Cell | 1 1 1 1 1 1 1 1 1 1 2 1 1 1|
Artery, Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Infiltration Cellular, Mononuclear | |
Cell | 1 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Mineralization | |
Germinal Epithelium, Atrophy | 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + |
Inguinal, Hyperplasia, Plasma Cell | |
Lumbar, Hyperplasia, Plasma Cell | |
Mediastinal, Hyperplasia, Plasma Cell| |
Pancreatic, Hyperplasia, Lymphoid | |
Renal, Hyperplasia, Plasma Cell | |
Renal, Inflammation, Suppurative | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + M + + + + M + + + + +|
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + M + M + M + + M + + + M + + + + + + + + +|
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 2 3 4 2 2 2 |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + M + + + + + + M + +|
Cyst | 2 2 2 2 1 2 2 |
Ectopic Parathyroid Gland | 2 |
Mineralization | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Epidermis, Hyperplasia | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 2| 2| 2| 3| 3| 3| 3| 3| 3| 2| 2| 2| 6| 2| 3| 2| 2| 2| 3| 3| 1| 3| 3|
| 1| 1| 9| 9| 9| 1| 0| 1| 1| 1| 1| 5| 9| 9| 3| 9| 0| 9| 9| 9| 1| 0| 4| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
1.5 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Epidermis, Ulcer | |
Subcutaneous Tissue, Fibrosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Infiltration Cellular, Mononuclear | |
Cell | |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | 2 |
Mineralization | 1 |
Thrombosis | 2 |
Alveolar Epithelium, Hyperplasia | 2 2 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 3 2 2 3|
Mediastinum, Inflammation, | |
Suppurative | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cornea, Inflammation, Chronic Active | 2 |
Cornea, Metaplasia, Squamous | 4 |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | |
Infiltration Cellular, Mononuclear | |
Cell | 1 1 1 1 1 2 1 1 1 3 1 1 1 1 1 1 1 1 |
Metaplasia, Osseous | |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Nephropathy | 2 1 1 1 2 2 2 2 1 2 2 2 1 2 1 2 2 2 2 1 1 2 2 2|
Artery, Inflammation, Chronic Active | 3 |
Cortex, Cyst | 2 3 2 2 |
Renal Tubule, Hyperplasia | 2 2 2 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 2| 2| 2| 3| 3| 3| 3| 3| 3| 2| 2| 2| 6| 2| 3| 2| 2| 2| 3| 3| 1| 3| 3|
| 1| 1| 9| 9| 9| 1| 0| 1| 1| 1| 1| 5| 9| 9| 3| 9| 0| 9| 9| 9| 1| 0| 4| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
1.5 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mononuclear | |
Cell | 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 2| 3| 2| 3| 3| 2| 2| 2| 2| 3| 2| 0| 2| 3| 3| |
| 0| 0| 0| 0| 0| 4| 1| 1| 0| 0| 9| 0| 9| 1| 0| 9| 9| 9| 5| 0| 9| 5| 9| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
1.5 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Periesophageal Tissue, Inflammation, | | |
Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 3 | 3 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X | 4 |
Clear Cell Focus | X X X X | 10 |
Eosinophilic Focus | X X X X X X | 10 |
Infiltration Cellular, Mononuclear | | |
Cell | 1 1 1 1 1 | 11 1.0|
Inflammation, Chronic Active | 1 2 1 1 1 1 1 2 1 1 1 1 1 1 1| 21 1.1|
Mixed Cell Focus | X X X X X X X | 11 |
Necrosis | 2 | 5 2.2|
Hepatocyte, Vacuolization Cytoplasmic| 2 2 2 2 1 | 10 1.6|
__________________________________________________________________________|____________|
Mesentery | + + + + | 6 |
Fibrosis | | 1 2.0|
Inflammation, Chronic Active | 2 | 1 2.0|
Mineralization | 2 | 1 2.0|
Fat, Necrosis | 3 | 2 3.5|
__________________________________________________________________________|____________|
Oral Mucosa | + + + + + + + + + + + + + + +| 30 |
Gingival, Foreign Body | X X X X X X X X X X X X X X| 29 |
Gingival, Inflammation, Acute | | 3 1.3|
Gingival, Inflammation, Chronic | | 1 1.0|
Gingival, Inflammation, Chronic | | |
Active | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3| 26 1.8|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Mononuclear | | |
Cell | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Mononuclear | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 2| 3| 2| 3| 3| 2| 2| 2| 2| 3| 2| 0| 2| 3| 3| |
| 0| 0| 0| 0| 0| 4| 1| 1| 0| 0| 9| 0| 9| 1| 0| 9| 9| 9| 5| 0| 9| 5| 9| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
1.5 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 35 1.0|
Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Hyperplasia | 2 | 3 2.0|
Epithelium, Inflammation, Chronic | | |
Active | 2 | 1 2.0|
Epithelium, Ulcer | 4 | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 2.0|
Mineralization | 1 | 1 1.0|
Epithelium, Hyperplasia | | 1 2.0|
Epithelium, Inflammation, Chronic | | |
Active | 2 | 1 2.0|
Glands, Ectasia | 1 1 1 1 1 1 | 10 1.1|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 1.0|
Artery, Inflammation, Chronic Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 1 1 2 1| 12 1.6|
Hypertrophy | 2 2 1 2 3 1 2 3 2 2 3 2 2 1 2 1 1 1| 34 1.9|
Inflammation, Suppurative | 1 | 1 1.0|
Capsule, Hyperplasia | 2 1 1 2 1 1 1 2 1 1 2 1 2 2 1 1 1 1 2 2 | 41 1.5|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 3 2 2| 43 2.1|
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + M + M M + + M + + M + + + + M + + M + +| 35 |
Cyst | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Cyst | 2 2 | 2 2.0|
Pars Distalis, Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicle, Cyst | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 2| 3| 2| 3| 3| 2| 2| 2| 2| 3| 2| 0| 2| 3| 3| |
| 0| 0| 0| 0| 0| 4| 1| 1| 0| 0| 9| 0| 9| 1| 0| 9| 9| 9| 5| 0| 9| 5| 9| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
1.5 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Mononuclear | | |
Cell | 1 1 2 1 1 1 1 1 1 2 1 | 26 1.1|
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Mononuclear | | |
Cell | 2 1 2 1 1 3 1 1 1 1 1| 25 1.4|
Inflammation, Chronic Active | 3 2 | 6 2.3|
Duct, Cyst | 2 2 2 3 2 3 2 3 2 2 3 | 20 2.3|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Mononuclear | | |
Cell | 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1| 31 1.1|
Artery, Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 4 | 1 4.0|
Infiltration Cellular, Mononuclear | | |
Cell | 1 | 2 1.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 2.0|
Mineralization | 1 1 | 2 1.0|
Germinal Epithelium, Atrophy | | 2 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + | 5 |
Inguinal, Hyperplasia, Plasma Cell | 2 | 1 2.0|
Lumbar, Hyperplasia, Plasma Cell | 3 | 1 3.0|
Mediastinal, Hyperplasia, Plasma Cell| 2 | 1 2.0|
Pancreatic, Hyperplasia, Lymphoid | 4 | 1 4.0|
Renal, Hyperplasia, Plasma Cell | 4 | 1 4.0|
Renal, Inflammation, Suppurative | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia, Lymphoid | 4 | 1 4.0|
Hyperplasia, Plasma Cell | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + M + + + + + + + + + + M + + +| 43 |
Hyperplasia, Lymphoid | 4 | 1 4.0|
Hyperplasia, Plasma Cell | 4 | 1 4.0|
Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 2| 3| 2| 3| 3| 2| 2| 2| 2| 3| 2| 0| 2| 3| 3| |
| 0| 0| 0| 0| 0| 4| 1| 1| 0| 0| 9| 0| 9| 1| 0| 9| 9| 9| 5| 0| 9| 5| 9| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
1.5 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hematopoietic Cell Proliferation | 2 2 3 3 2 3 | 13 2.5|
Hyperplasia, Lymphoid | 3 4 3 | 4 3.3|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Cyst | 2 2 2 1 2 2 2 2 1 1 2 2| 19 1.8|
Ectopic Parathyroid Gland | | 1 2.0|
Mineralization | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 1 4 | 2 2.5|
Epidermis, Hyperplasia | 3 4 | 2 3.5|
Epidermis, Ulcer | 1 4 | 2 2.5|
Subcutaneous Tissue, Fibrosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 2.0|
Infiltration Cellular, Mononuclear | | |
Cell | 2 | 1 2.0|
Inflammation, Chronic | | 1 1.0|
Inflammation, Chronic Active | 3 | 2 2.5|
Mineralization | | 1 1.0|
Thrombosis | 1 | 2 1.5|
Alveolar Epithelium, Hyperplasia | 2 2 2 | 6 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 2 3 2| 8 2.4|
Mediastinum, Inflammation, | | |
Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X | 3 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 2| 3| 2| 3| 3| 2| 2| 2| 2| 3| 2| 0| 2| 3| 3| |
| 0| 0| 0| 0| 0| 4| 1| 1| 0| 0| 9| 0| 9| 1| 0| 9| 9| 9| 5| 0| 9| 5| 9| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
1.5 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Cornea, Inflammation, Chronic Active | | 1 2.0|
Cornea, Metaplasia, Squamous | | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct | 4 3| 2 3.5|
Infiltration Cellular, Mononuclear | | |
Cell | 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 2 1 1| 37 1.1|
Metaplasia, Osseous | 2 | 1 2.0|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 49 1.0|
Nephropathy | 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 1 1 2 2 1 2 2| 48 1.8|
Artery, Inflammation, Chronic Active | | 1 3.0|
Cortex, Cyst | 2 2 2 2 2 2 2 1 | 12 2.0|
Renal Tubule, Hyperplasia | 2 2 2 2 2 | 8 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Mononuclear | | |
Cell | 1 1 1 1 1 1 1 1 1 1 1 1| 17 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 2| 3| 3| 3| 2| 2| 5| 3| 3| 2| 2| 3| 3| 3| 3| 3| 3| 2| 3| 3| 2| 3| 2|
| 0| 1| 9| 1| 1| 0| 9| 9| 5| 9| 0| 9| 9| 1| 0| 1| 0| 1| 1| 9| 1| 0| 9| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
3 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Hyperplasia | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | X X X |
Clear Cell Focus | X X X X X X |
Eosinophilic Focus | X X X X X X X |
Fibrosis | |
Hematopoietic Cell Proliferation | 2 1 |
Infiltration Cellular, Mononuclear | |
Cell | 1 1 1 |
Inflammation, Chronic Active | 1 3 1 1 2 1 1 1 1 1 1|
Inflammation, Granulomatous | 3 |
Mineralization | |
Mixed Cell Focus | X X X X X |
Necrosis | 2 |
Pigmentation | |
Tension Lipidosis | X |
Bile Duct, Cyst | 3 |
Hepatocyte, Vacuolization Cytoplasmic| 1 1 1 2 |
Hepatocyte, Portal, Hypertrophy | |
Hepatocyte, Centrilobular, | |
Degeneration | |
__________________________________________________________________________|
Mesentery | + + + + + |
Inflammation, Chronic Active | 3 |
Inflammation, Granulomatous | 3 3 |
Mineralization | 1 |
Fat, Necrosis | 4 |
__________________________________________________________________________|
Oral Mucosa | + + + + + + + + + +|
Gingival, Foreign Body | X X X X X X X X X|
Gingival, Inflammation, Acute | 1 1 1 2 1|
Gingival, Inflammation, Chronic | |
Active | 1 2 1 2 1 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 2| 3| 3| 3| 2| 2| 5| 3| 3| 2| 2| 3| 3| 3| 3| 3| 3| 2| 3| 3| 2| 3| 2|
| 0| 1| 9| 1| 1| 0| 9| 9| 5| 9| 0| 9| 9| 1| 0| 1| 0| 1| 1| 9| 1| 0| 9| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
3 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Infiltration Cellular, Mononuclear | |
Cell | 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 |
Inflammation, Chronic Active | 4 |
Mineralization | 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst, Squamous | |
Epithelium, Hyperplasia | 3 |
Epithelium, Inflammation, Chronic | |
Active | 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | 2 |
Epithelium, Inflammation, Chronic | |
Active | 2 |
Glands, Ectasia | 1 1 1 1 1 1 1 1 1 1 |
Serosa, Inflammation, Granulomatous | 3 |
__________________________________________________________________________|
Tooth | |
Malformation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 |
Hyperplasia | 1 2 2 1 2 2 2 2 2 |
Hypertrophy | 1 2 1 2 2 1 2 2 1 2 2 1 2 |
Capsule, Hyperplasia | 1 2 1 1 2 2 2 1 1 1 1 1 2 2 1 1 2 1 1 1 2 1 1|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2 |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + + M + + + + + + + + + + +|
Cyst | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 1 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | 3 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 2| 3| 3| 3| 2| 2| 5| 3| 3| 2| 2| 3| 3| 3| 3| 3| 3| 2| 3| 3| 2| 3| 2|
| 0| 1| 9| 1| 1| 0| 9| 9| 5| 9| 0| 9| 9| 1| 0| 1| 0| 1| 1| 9| 1| 0| 9| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
3 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Coagulating Gland | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 2 |
Infiltration Cellular, Mononuclear | |
Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Mineralization | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mononuclear | |
Cell | 1 1 1 2 1 2 1 1 2 2 1 2 1 2 1 |
Inflammation, Chronic Active | 3 3 2 2 2|
Duct, Cyst | 2 2 2 3 3 2 2 2 2|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mononuclear | |
Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Inflammation, Suppurative | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mononuclear | |
Cell | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Mineralization | |
Germinal Epithelium, Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 4 |
__________________________________________________________________________|
Lymph Node | + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Plasma Cell | |
Infiltration Cellular, | |
Polymorphonuclear | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 2 2 3 4 2 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | + + + M + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | |
Cyst | 2 2 2 2 2 |
Ectopic Parathyroid Gland | |
Thymocyte, Necrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 2| 3| 3| 3| 2| 2| 5| 3| 3| 2| 2| 3| 3| 3| 3| 3| 3| 2| 3| 3| 2| 3| 2|
| 0| 1| 9| 1| 1| 0| 9| 9| 5| 9| 0| 9| 9| 1| 0| 1| 0| 1| 1| 9| 1| 0| 9| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
3 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mononuclear | |
Cell | 1 |
Inflammation, Chronic Active | 4 4 1 |
Epidermis, Hyperkeratosis | 2 |
Epidermis, Hyperplasia | 3 3 |
Epidermis, Ulcer | 4 4 |
Epidermis, Pinna, Hyperplasia | 3 |
Epidermis, Pinna, Ulcer | 4 |
Pinna, Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Thrombosis | 2 |
Alveolar Epithelium, Hyperplasia | 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X X |
Inflammation, Chronic Active | 1 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | |
Infiltration Cellular, Mononuclear | |
Cell | 1 1 1 3 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Inflammation, Chronic Active | 2 |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 2| 3| 3| 3| 2| 2| 5| 3| 3| 2| 2| 3| 3| 3| 3| 3| 3| 2| 3| 3| 2| 3| 2|
| 0| 1| 9| 1| 1| 0| 9| 9| 5| 9| 0| 9| 9| 1| 0| 1| 0| 1| 1| 9| 1| 0| 9| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
3 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Nephropathy | 1 2 2 1 3 1 2 1 2 1 1 2 1 1 1 2 2 1 1 2 1 1 1 1|
Cortex, Cyst | |
Renal Tubule, Hyperplasia | 2 2 2 2 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Infiltration Cellular, Mononuclear | |
Cell | 1 1 1 |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 3| 2| 2| 3| 3| 2| 3| 2| 1| 3| 3| 9| 2| 3| 2| 3| 0| 2| 2| 3| 3| 0| |
| 9| 9| 9| 1| 9| 9| 0| 1| 9| 0| 9| 2| 0| 0| 4| 9| 1| 9| 1| 2| 9| 9| 1| 1| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
3 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 2 | 1 2.0|
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Peyer's Patch, Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 2.0|
Basophilic Focus | X X X | 6 |
Clear Cell Focus | X X X X | 10 |
Eosinophilic Focus | X X X X X | 12 |
Fibrosis | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 1 | 3 1.3|
Infiltration Cellular, Mononuclear | | |
Cell | 1 1 1 1 | 7 1.0|
Inflammation, Chronic Active | 1 1 1 1 1 1 2 1 | 19 1.2|
Inflammation, Granulomatous | | 1 3.0|
Mineralization | 2 | 1 2.0|
Mixed Cell Focus | X X X X X X | 11 |
Necrosis | | 1 2.0|
Pigmentation | 2 1 | 2 1.5|
Tension Lipidosis | | 1 |
Bile Duct, Cyst | | 1 3.0|
Hepatocyte, Vacuolization Cytoplasmic| 2 1 2 2 2 | 9 1.6|
Hepatocyte, Portal, Hypertrophy | 3 | 1 3.0|
Hepatocyte, Centrilobular, | | |
Degeneration | 3 | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + | 6 |
Inflammation, Chronic Active | | 1 3.0|
Inflammation, Granulomatous | | 2 3.0|
Mineralization | | 1 1.0|
Fat, Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Oral Mucosa | + + + + + + + + + + + + + + + + +| 27 |
Gingival, Foreign Body | X X X X X X X X X X X X X X X X X| 26 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 3| 2| 2| 3| 3| 2| 3| 2| 1| 3| 3| 9| 2| 3| 2| 3| 0| 2| 2| 3| 3| 0| |
| 9| 9| 9| 1| 9| 9| 0| 1| 9| 0| 9| 2| 0| 0| 4| 9| 1| 9| 1| 2| 9| 9| 1| 1| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
3 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Gingival, Inflammation, Acute | 1 1 1 1 2 | 10 1.2|
Gingival, Inflammation, Chronic | | |
Active | 2 2 1 2 2 2 1 1 2 2 2| 16 1.6|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Mononuclear | | |
Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 36 1.0|
Inflammation, Chronic Active | | 1 4.0|
Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst, Squamous | 3 | 1 3.0|
Epithelium, Hyperplasia | | 1 3.0|
Epithelium, Inflammation, Chronic | | |
Active | | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Hyperplasia | | 1 2.0|
Epithelium, Inflammation, Chronic | | |
Active | | 1 2.0|
Glands, Ectasia | 1 1 2 1 1 1 1 1 1 1 | 20 1.1|
Serosa, Inflammation, Granulomatous | | 1 3.0|
__________________________________________________________________________|____________|
Tooth | + | 1 |
Malformation | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | | 1 1.0|
Hyperplasia | 1 2 1 2 2 2 2 | 16 1.8|
Hypertrophy | 1 2 2 2 1 1 2 2 2 1 2 1 2 2 1| 28 1.6|
Capsule, Hyperplasia | 2 1 2 2 1 2 2 1 1 1 1 2 1 3 2 2 1| 40 1.5|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 48 2.1|
__________________________________________________________________________|____________|
Parathyroid Gland | + M M M + M + + + M M + + + + + M + M + + + + M +| 39 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 3| 2| 2| 3| 3| 2| 3| 2| 1| 3| 3| 9| 2| 3| 2| 3| 0| 2| 2| 3| 3| 0| |
| 9| 9| 9| 1| 9| 9| 0| 1| 9| 0| 9| 2| 0| 0| 4| 9| 1| 9| 1| 2| 9| 9| 1| 1| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
3 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + I + + + + + + + +| 49 |
Pars Distalis, Cyst | 2 2 1 | 5 1.6|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicle, Cyst | | 2 2.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | +| 1 |
Inflammation, Suppurative | 3| 1 3.0|
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma Sperm | | 1 2.0|
Infiltration Cellular, Mononuclear | | |
Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 30 1.0|
Mineralization | 1 | 1 1.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Mononuclear | | |
Cell | 1 1 2 1 1 1 1 2 1 2 2 2| 27 1.4|
Inflammation, Chronic Active | 4 1 | 7 2.4|
Duct, Cyst | 3 2 2 2 2 2 2 3 2 | 18 2.2|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Mononuclear | | |
Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 34 1.0|
Inflammation, Suppurative | 3| 1 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Mononuclear | | |
Cell | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 4 | 1 4.0|
Mineralization | 1 | 1 1.0|
Germinal Epithelium, Atrophy | 3 2 | 2 2.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 4 4 | 4 3.8|
__________________________________________________________________________|____________|
Lymph Node | + | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 3| 2| 2| 3| 3| 2| 3| 2| 1| 3| 3| 9| 2| 3| 2| 3| 0| 2| 2| 3| 3| 0| |
| 9| 9| 9| 1| 9| 9| 0| 1| 9| 0| 9| 2| 0| 0| 4| 9| 1| 9| 1| 2| 9| 9| 1| 1| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
3 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia, Plasma Cell | 3 | 1 3.0|
Infiltration Cellular, | | |
Polymorphonuclear | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + M + + + + + + + + + + + +| 49 |
Hyperplasia, Lymphoid | | 1 3.0|
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 2 2 3 3 2 2 3 | 14 2.4|
Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + M + + + + + + + + + M + + + + M + + +| 46 |
Atypia Cellular | 1 | 1 1.0|
Cyst | 1 1 2 2 2 1 1 2 2 1 2 2 2| 18 1.7|
Ectopic Parathyroid Gland | 2 2 1 | 3 1.7|
Thymocyte, Necrosis | 2| 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Mononuclear | | |
Cell | | 1 1.0|
Inflammation, Chronic Active | | 3 3.0|
Epidermis, Hyperkeratosis | | 1 2.0|
Epidermis, Hyperplasia | | 2 3.0|
Epidermis, Ulcer | | 2 4.0|
Epidermis, Pinna, Hyperplasia | | 1 3.0|
Epidermis, Pinna, Ulcer | | 1 4.0|
Pinna, Inflammation, Chronic Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 2.0|
Thrombosis | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 3| 2| 2| 3| 3| 2| 3| 2| 1| 3| 3| 9| 2| 3| 2| 3| 0| 2| 2| 3| 3| 0| |
| 9| 9| 9| 1| 9| 9| 0| 1| 9| 0| 9| 2| 0| 0| 4| 9| 1| 9| 1| 2| 9| 9| 1| 1| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
3 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolar Epithelium, Hyperplasia | 3 2 2 2 | 5 2.2|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 | 3 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X X | 4 |
Inflammation, Chronic Active | 4 2 | 3 2.3|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 4 | 1 4.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + + | 7 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct | 2 | 1 2.0|
Infiltration Cellular, Mononuclear | | |
Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 39 1.1|
Inflammation, Chronic Active | | 1 2.0|
Inflammation, Suppurative | 1| 1 1.0|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 47 1.0|
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 2 1 2 1 1 2 1 1 2 2 1| 47 1.3|
Cortex, Cyst | 3 2 1 2 1 2 2 2 | 8 1.9|
Renal Tubule, Hyperplasia | 2 2 2 | 9 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3| 1 3.0|
Infiltration Cellular, Mononuclear | | |
Cell | 1 1 1 1 1 1 | 9 1.0|
Inflammation, Suppurative | 2| 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 6| 7| 7| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 3| 3| 3| 3| 3| 2| 3| 3| 0| 2| 3| 3| 8| 8| 8| 8| 8| 8| 8| 3| 3| 2| 3|
| 0| 9| 0| 0| 0| 0| 0| 9| 1| 0| 3| 1| 1| 0| 1| 1| 1| 1| 1| 1| 1| 1| 0| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
6 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Clear Cell Focus | X X X |
Eosinophilic Focus | X|
Hematopoietic Cell Proliferation | 1 |
Infiltration Cellular, Mononuclear | |
Cell | 1 1 1 1 1 |
Inflammation, Chronic Active | 1 1 1 1 1 2 1 1 1 1 1 1 |
Mixed Cell Focus | X |
Pigmentation | 1 1 |
Bile Duct, Cyst | 3 |
Bile Duct, Hyperplasia | 3 |
Hepatocyte, Vacuolization Cytoplasmic| 2 1 1 1 2 2 2 1|
__________________________________________________________________________|
Mesentery | + |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Oral Mucosa | + + + + |
Gingival, Foreign Body | X X X X |
Gingival, Inflammation, Acute | 1 2 |
Gingival, Inflammation, Chronic | |
Active | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mononuclear | |
Cell | 2 |
Artery, Mineralization | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mononuclear | |
Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Glands, Ectasia | 1 1 1 2 |
__________________________________________________________________________|
Tooth | + + |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 6| 7| 7| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 3| 3| 3| 3| 3| 2| 3| 3| 0| 2| 3| 3| 8| 8| 8| 8| 8| 8| 8| 3| 3| 2| 3|
| 0| 9| 0| 0| 0| 0| 0| 9| 1| 0| 3| 1| 1| 0| 1| 1| 1| 1| 1| 1| 1| 1| 0| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
6 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Malformation | X X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Mineralization | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 3 1 1 1|
Hypertrophy | 1 1 2 2 2 2 2 1 2 1|
Capsule, Hyperplasia | 2 2 1 2 2 1 1 1 1 1 1 2 3 1 1 1 1 1 1 1 2 2 1 2|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 2 3 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M + + + M M M M + + + + + + +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | 2 |
Pars Distalis, Cyst | 1 2 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mononuclear | |
Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + M + + + + + + + + + + + + +|
Infiltration Cellular, Mononuclear | |
Cell | 1 1 1 2 1 1 2 2 1 1 1 2 1 1|
Inflammation, Chronic Active | 2 |
Duct, Cyst | 2 2 2 3 3 3 2 2 2 2|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mononuclear | |
Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 6| 7| 7| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 3| 3| 3| 3| 3| 2| 3| 3| 0| 2| 3| 3| 8| 8| 8| 8| 8| 8| 8| 3| 3| 2| 3|
| 0| 9| 0| 0| 0| 0| 0| 9| 1| 0| 3| 1| 1| 0| 1| 1| 1| 1| 1| 1| 1| 1| 0| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
6 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + M + + + + + + + + + + + + +|
Cyst | 1 2 2 1 2 1 2 |
Ectopic Parathyroid Gland | 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Mineralization | |
Thrombosis | |
Alveolar Epithelium, Hyperplasia | 2 2 2|
Alveolus, Infiltration Cellular, | |
Histiocyte | 3 3 |
Mediastinum, Inflammation, Chronic | |
Active | 2 |
Pleura, Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mononuclear | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 6| 7| 7| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 3| 3| 3| 3| 3| 2| 3| 3| 0| 2| 3| 3| 8| 8| 8| 8| 8| 8| 8| 3| 3| 2| 3|
| 0| 9| 0| 0| 0| 0| 0| 9| 1| 0| 3| 1| 1| 0| 1| 1| 1| 1| 1| 1| 1| 1| 0| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
6 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Nephropathy | 1 2 2 1 2 2 1 2 2 1 1 1 1 1 1 1 1 1 2 2 1 2|
Cortex, Cyst | 2 2 2 2|
Renal Tubule, Hyperplasia | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mononuclear | |
Cell | 1 1 1 1 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 2| 2| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 3| 2| 2| 1| 2| |
| 1| 3| 9| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 9| 9| 0| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
6 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + M + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Peyer's Patch, Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X | 2 |
Clear Cell Focus | X | 4 |
Eosinophilic Focus | X X | 3 |
Hematopoietic Cell Proliferation | | 1 1.0|
Infiltration Cellular, Mononuclear | | |
Cell | 1 | 6 1.0|
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 2 | 21 1.1|
Mixed Cell Focus | X | 2 |
Pigmentation | 2 | 3 1.3|
Bile Duct, Cyst | | 1 3.0|
Bile Duct, Hyperplasia | | 1 3.0|
Hepatocyte, Vacuolization Cytoplasmic| 1 2 2 2 1 2 1 2 | 16 1.6|
__________________________________________________________________________|____________|
Mesentery | | 1 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Oral Mucosa | + + + + + +| 10 |
Gingival, Foreign Body | X X X X X X| 10 |
Gingival, Inflammation, Acute | 1 1 1 1| 6 1.2|
Gingival, Inflammation, Chronic | | |
Active | 2 | 2 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Mononuclear | | |
Cell | | 1 2.0|
Artery, Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Mononuclear | | |
Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 | 29 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 2| 2| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 3| 2| 2| 1| 2| |
| 1| 3| 9| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 9| 9| 0| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
6 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Epithelium, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 1 1 | 2 1.0|
Glands, Ectasia | 1 | 5 1.2|
__________________________________________________________________________|____________|
Tooth | | 2 |
Malformation | | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 2.0|
Mineralization | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 7 1.4|
Hypertrophy | 2 1 2 1 2| 15 1.6|
Capsule, Hyperplasia | 2 2 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1| 45 1.3|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 46 2.1|
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + + M + M M M M + + + M + + + + + + +| 38 |
Cyst | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + I + + + + I + + + + + + I + + + + I + + + + + +| 46 |
Atypia Cellular | | 1 2.0|
Pars Distalis, Cyst | | 3 1.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + + | 2 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Mononuclear | | |
Cell | 1 1 1 1 1 1 1 1| 21 1.0|
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Infiltration Cellular, Mononuclear | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 2| 2| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 3| 2| 2| 1| 2| |
| 1| 3| 9| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 9| 9| 0| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
6 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Cell | 1 1 2 1 1 1 1 1 1 1 2 2 | 26 1.3|
Inflammation, Chronic Active | 2 4 | 3 2.7|
Duct, Cyst | 2 3 2 2 3 3 | 16 2.4|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Mononuclear | | |
Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 32 1.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + M + + M + + + + + + + + + I +| 47 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + M + + + + + M + + + M + + + + + + + + + + + + +| 47 |
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 2 2 3 3 | 4 2.5|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 1 1 1 2 2 1 2 2 2 1| 17 1.5|
Ectopic Parathyroid Gland | | 1 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M + M M M M + M M M M M M M M M M| 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 3 1 1 | 4 1.8|
Mineralization | 1 1| 2 1.0|
Thrombosis | 3 | 1 3.0|
Alveolar Epithelium, Hyperplasia | 1 | 4 1.8|
Alveolus, Infiltration Cellular, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99
Route: GAVAGE Time: 08:33:12
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 2| 2| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 3| 2| 2| 1| 2| |
| 1| 3| 9| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 9| 9| 0| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
6 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Histiocyte | 2 | 3 2.7|
Mediastinum, Inflammation, Chronic | | |
Active | | 1 2.0|
Pleura, Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Mononuclear | | |
Cell | 1 1 1 1 1 1 1 1 1| 22 1.0|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2| 36 1.0|
Nephropathy | 2 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 2| 39 1.3|
Cortex, Cyst | 2 2 2 2 2 | 9 2.0|
Renal Tubule, Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Mononuclear | | |
Cell | 1 1 1 1 1 1 | 10 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------