TDMS Study 88070-03 Pathology Tables
NTP Experiment-Test: 88070-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC ISOBUTENE Date: 06/11/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:48 CORE STUDY Facility: Battelle Northwest Chemical CAS #: 115-11-0007 Lock Date: 10/05/95 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 88070-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC ISOBUTENE Date: 06/11/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:48 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE CONTROL 500 PPM 2000 PPM 8000 PPM ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 50 50 50 50 Early Deaths Moribund Sacrifice 21 25 15 23 Natural Death 6 5 2 5 Accidently Killed 1 Survivors Terminal Sacrifice 23 19 33 22 Animals Examined Microscopically 50 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Large, Colon (49) (50) (49) (49) Intestine Large, Rectum (47) (47) (47) (48) Polyp Adenomatous 1 (2%) Intestine Large, Cecum (48) (49) (48) (49) Intestine Small, Duodenum (49) (50) (48) (48) Intestine Small, Jejunum (47) (47) (48) (47) Leiomyosarcoma 1 (2%) Intestine Small, Ileum (46) (47) (48) (47) Liver (50) (50) (50) (49) Carcinoma, Metastatic, Thyroid Gland 1 (2%) Hepatocellular Carcinoma 1 (2%) Mesentery (8) (10) (12) (7) Oral Mucosa (1) Pharyngeal, Squamous Cell Papilloma 1 (100%) Pancreas (50) (50) (49) (49) Salivary Glands (50) (50) (50) (50) Stomach, Glandular (50) (50) (50) (49) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (50) (50) (49) (50) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (50) (50) (49) (49) Adenoma 1 (2%) 1 (2%) 1 (2%) 1 (2%) Adrenal Medulla (50) (50) (49) (49) Pheochromocytoma Complex 1 (2%) Pheochromocytoma Benign 3 (6%) 3 (6%) 9 (18%) 4 (8%) Bilateral, Pheochromocytoma Benign 1 (2%) Page 2 NTP Experiment-Test: 88070-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC ISOBUTENE Date: 06/11/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:48 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE CONTROL 500 PPM 2000 PPM 8000 PPM ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont Islets, Pancreatic (50) (50) (49) (49) Adenoma 1 (2%) Pituitary Gland (50) (49) (50) (49) Pars Distalis, Adenoma 39 (78%) 33 (67%) 37 (74%) 36 (73%) Thyroid Gland (50) (50) (49) (49) C-Cell, Adenoma 7 (14%) 6 (12%) 3 (6%) 5 (10%) C-Cell, Carcinoma 2 (4%) 3 (6%) 6 (12%) 2 (4%) Follicular Cell, Carcinoma 1 (2%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Clitoral Gland (50) (49) (47) (48) Adenoma 3 (6%) 3 (6%) 6 (13%) Carcinoma 5 (11%) 1 (2%) Bilateral, Carcinoma 1 (2%) Ovary (50) (50) (50) (50) Granulosa Cell Tumor Malignant 1 (2%) Uterus (50) (50) (50) (50) Polyp Stromal 7 (14%) 9 (18%) 7 (14%) 4 (8%) Polyp Stromal, Multiple 1 (2%) 1 (2%) 1 (2%) Vagina (1) (1) (1) Polyp 1 (100%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (50) (50) (49) (49) Lymph Node (6) (3) (3) (2) Deep Cervical, Carcinoma, Metastatic, Thyroid Gland 1 (50%) Renal, Sarcoma 1 (17%) Lymph Node, Bronchial (36) (31) (36) (27) Lymph Node, Mandibular (44) (46) (47) (47) Lymph Node, Mesenteric (50) (50) (49) (49) Lymph Node, Mediastinal (42) (45) (39) (45) Plasma Cell Tumor Malignant 1 (2%) Spleen (50) (50) (49) (50) Hemangiosarcoma 1 (2%) Thymus (48) (47) (45) (41) ____________________________________________________________________________________________________________________________________ Page 3 NTP Experiment-Test: 88070-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC ISOBUTENE Date: 06/11/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:48 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE CONTROL 500 PPM 2000 PPM 8000 PPM ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (50) (50) (50) (50) Adenoma 1 (2%) 1 (2%) 1 (2%) Carcinoma 2 (4%) 2 (4%) 4 (8%) 4 (8%) Fibroadenoma 16 (32%) 14 (28%) 24 (48%) 22 (44%) Fibroadenoma, Multiple 6 (12%) 5 (10%) 6 (12%) 5 (10%) Skin (50) (50) (50) (50) Keratoacanthoma 1 (2%) 1 (2%) Squamous Cell Papilloma 1 (2%) Subcutaneous Tissue, Fibroma 1 (2%) 1 (2%) Subcutaneous Tissue, Fibrosarcoma 1 (2%) Subcutaneous Tissue, Fibrous Histiocytoma Malignant 1 (2%) Subcutaneous Tissue, Hemangioma 1 (2%) Subcutaneous Tissue, Melanoma Malignant 1 (2%) Subcutaneous Tissue, Sarcoma 1 (2%) 2 (4%) Subcutaneous Tissue, Schwannoma Malignant 1 (2%) Subcutaneous Tissue, Pinna, Melanoma Malignant 1 (2%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (50) (50) (50) (50) Osteosarcoma 1 (2%) Sarcoma 1 (2%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (50) (50) (50) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (50) (50) (50) (50) Adenoma 1 (2%) Alveolar/Bronchiolar Adenoma 2 (4%) Carcinoma, Metastatic, Mammary Gland 1 (2%) Carcinoma, Metastatic, Thyroid Gland 2 (4%) 1 (2%) Fibrosarcoma, Metastatic, Skin 1 (2%) Plasma Cell Tumor Malignant, Metastatic, Lymph Node, Mediastinal 1 (2%) Mediastinum, Plasma Cell Tumor Malignant, Metastatic, Lymph Node, Mediastinal 1 (2%) Nose (50) (50) (50) (49) ____________________________________________________________________________________________________________________________________ Page 4 NTP Experiment-Test: 88070-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC ISOBUTENE Date: 06/11/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:48 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE CONTROL 500 PPM 2000 PPM 8000 PPM ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Zymbal's Gland (1) Carcinoma 1 (100%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (50) (49) (49) Lipoma 1 (2%) Stromal Nephroma 1 (2%) Renal Tubule, Carcinoma 1 (2%) Urinary Bladder (50) (49) (49) (49) Transitional Epithelium, Papilloma 1 (2%) ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS Multiple Organs *(50) *(50) *(50) *(50) Leukemia Mononuclear 18 (36%) 16 (32%) 22 (44%) 17 (34%) ____________________________________________________________________________________________________________________________________ * Number of animals with any tissue examined microscopically Page 5 NTP Experiment-Test: 88070-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC ISOBUTENE Date: 06/11/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:48 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE CONTROL 500 PPM 2000 PPM 8000 PPM ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 50 48 49 48 Total Primary Neoplasms 125 102 140 107 Total Animals with Benign Neoplasms 42 45 48 46 Total Benign Neoplasms 92 76 100 80 Total Animals with Malignant Neoplasms 30 24 30 25 Total Malignant Neoplasms 33 26 40 27 Total Animals with Metastatic Neoplasms 2 2 2 1 Total Metastatic Neoplasm 3 2 2 2 Total Animals with Malignant Neoplasms Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant Total Uncertain Neoplasms ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors Page 6 NTP Experiment-Test: 88070-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC ISOBUTENE Date: 06/11/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:48 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE CONTROL 500 PPM 2000 PPM 8000 PPM ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 50 50 50 50 Early Deaths Moribund Sacrifice 39 40 37 41 Natural Death 4 5 7 1 Survivors Terminal Sacrifice 7 5 6 8 Animals Examined Microscopically 50 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Large, Colon (49) (48) (48) (49) Intestine Large, Rectum (47) (49) (49) (49) Polyp Adenomatous 1 (2%) Intestine Large, Cecum (48) (47) (49) (49) Intestine Small, Jejunum (47) (46) (47) (49) Carcinoma 1 (2%) 1 (2%) Hemangiosarcoma 1 (2%) Intestine Small, Ileum (47) (46) (47) (49) Leiomyosarcoma 1 (2%) Liver (50) (50) (50) (50) Histiocytic Sarcoma 1 (2%) 2 (4%) Osteosarcoma, Metastatic, Bone 1 (2%) Mesentery (15) (10) (8) (11) Liposarcoma 1 (10%) Oral Mucosa (1) Pharyngeal, Squamous Cell Papilloma 1 (100%) Pancreas (50) (50) (50) (50) Adenoma 2 (4%) 1 (2%) Salivary Glands (50) (50) (50) (50) Stomach, Forestomach (50) (50) (50) (50) Stomach, Glandular (50) (49) (50) (50) Tongue (1) (1) Hemangiosarcoma 1 (100%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (50) (50) (50) (50) ____________________________________________________________________________________________________________________________________ Page 7 NTP Experiment-Test: 88070-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC ISOBUTENE Date: 06/11/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:48 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE CONTROL 500 PPM 2000 PPM 8000 PPM ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (50) (49) (50) (50) Adenoma 1 (2%) 1 (2%) Osteosarcoma, Metastatic, Bone 1 (2%) Adrenal Medulla (50) (49) (50) (50) Pheochromocytoma Malignant 1 (2%) 1 (2%) 2 (4%) Pheochromocytoma Benign 13 (26%) 7 (14%) 8 (16%) 11 (22%) Bilateral, Pheochromocytoma Malignant 1 (2%) Bilateral, Pheochromocytoma Benign 10 (20%) 11 (22%) 8 (16%) 12 (24%) Islets, Pancreatic (50) (49) (50) (50) Adenoma 4 (8%) 1 (2%) 4 (8%) Carcinoma 4 (8%) 2 (4%) 1 (2%) 4 (8%) Pituitary Gland (50) (49) (50) (49) Pars Distalis, Adenoma 43 (86%) 40 (82%) 40 (80%) 41 (84%) Thyroid Gland (48) (48) (48) (50) C-Cell, Adenoma 5 (10%) 4 (8%) 5 (10%) 7 (14%) C-Cell, Carcinoma 2 (4%) 1 (2%) Follicular Cell, Carcinoma 1 (2%) 5 (10%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Epididymis (50) (50) (50) (50) Preputial Gland (50) (50) (49) (50) Adenoma 4 (8%) 2 (4%) 2 (4%) 1 (2%) Carcinoma 1 (2%) 2 (4%) 2 (4%) 3 (6%) Bilateral, Carcinoma 1 (2%) Prostate (50) (49) (50) (50) Adenoma 1 (2%) Seminal Vesicle (50) (47) (50) (50) Testes (50) (50) (50) (50) Bilateral, Interstitial Cell, Adenoma 13 (26%) 14 (28%) 17 (34%) 14 (28%) Interstitial Cell, Adenoma 10 (20%) 14 (28%) 12 (24%) 11 (22%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (50) (48) (50) (50) Histiocytic Sarcoma 2 (4%) Lymph Node (4) (11) (10) (10) Histiocytic Sarcoma 1 (25%) 1 (10%) Iliac, Osteosarcoma, Metastatic, Bone 1 (25%) Page 8 NTP Experiment-Test: 88070-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC ISOBUTENE Date: 06/11/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:48 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE CONTROL 500 PPM 2000 PPM 8000 PPM ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont Pancreatic, Histiocytic Sarcoma 1 (10%) Lymph Node, Bronchial (30) (41) (35) (45) Histiocytic Sarcoma 1 (3%) 2 (6%) Lymph Node, Mandibular (47) (47) (49) (49) Lymph Node, Mesenteric (50) (50) (49) (50) Lymph Node, Mediastinal (46) (42) (44) (45) Carcinoma, Metastatic, Thyroid Gland 1 (2%) Histiocytic Sarcoma 1 (2%) Spleen (50) (49) (50) (50) Histiocytic Sarcoma 1 (2%) Thymus (40) (42) (38) (42) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (41) (41) (40) (44) Carcinoma 1 (2%) Carcinoma, Multiple 1 (2%) Fibroadenoma 1 (2%) 1 (3%) 1 (2%) Skin (50) (50) (50) (50) Basal Cell Adenoma 2 (4%) Basal Cell Carcinoma 2 (4%) Keratoacanthoma 3 (6%) 4 (8%) 2 (4%) 4 (8%) Squamous Cell Papilloma 1 (2%) 2 (4%) 1 (2%) Sebaceous Gland, Adenoma 2 (4%) 1 (2%) Subcutaneous Tissue, Fibroma 1 (2%) 2 (4%) Subcutaneous Tissue, Histiocytic Sarcoma 1 (2%) Subcutaneous Tissue, Lipoma 1 (2%) Subcutaneous Tissue, Rhabdomyosarcoma 1 (2%) Subcutaneous Tissue, Sarcoma 1 (2%) Subcutaneous Tissue, Schwannoma Benign 1 (2%) Subcutaneous Tissue, Schwannoma Malignant 1 (2%) Subcutaneous Tissue, Pinna, Melanoma Malignant 1 (2%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (50) (50) (50) (50) Osteosarcoma 1 (2%) 1 (2%) Skeletal Muscle (1) (1) (1) Histiocytic Sarcoma 1 (100%) ____________________________________________________________________________________________________________________________________ Page 9 NTP Experiment-Test: 88070-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC ISOBUTENE Date: 06/11/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:48 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE CONTROL 500 PPM 2000 PPM 8000 PPM ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (50) (50) (50) Astrocytoma Malignant 1 (2%) Histiocytic Sarcoma 1 (2%) Oligodendroglioma Malignant 1 (2%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (50) (50) (50) (50) Alveolar/Bronchiolar Adenoma 2 (4%) 2 (4%) 2 (4%) Alveolar/Bronchiolar Carcinoma 2 (4%) 1 (2%) 1 (2%) Carcinoma, Metastatic, Thyroid Gland 1 (2%) Histiocytic Sarcoma 1 (2%) 2 (4%) Osteosarcoma, Metastatic, Bone 1 (2%) Mediastinum, Alveolar/Bronchiolar Carcinoma, Metastatic, Lung 1 (2%) Nose (49) (49) (50) (49) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Eye (3) (4) Zymbal's Gland (2) (1) Carcinoma 2 (100%) 1 (100%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (50) (50) (50) Histiocytic Sarcoma 1 (2%) Stromal Nephroma 1 (2%) 1 (2%) Renal Tubule, Adenoma 2 (4%) 1 (2%) 2 (4%) Renal Tubule, Carcinoma 2 (4%) Urinary Bladder (50) (49) (50) (50) ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS Multiple Organs *(50) *(50) *(50) *(50) Histiocytic Sarcoma 1 (2%) 2 (4%) Leukemia Mononuclear 21 (42%) 21 (42%) 20 (40%) 31 (62%) Mesothelioma Malignant 3 (6%) 2 (4%) ____________________________________________________________________________________________________________________________________ * Number of animals with any tissue examined microscopically Page 10 NTP Experiment-Test: 88070-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC ISOBUTENE Date: 06/11/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:30:48 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE CONTROL 500 PPM 2000 PPM 8000 PPM ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 50 48 49 50 Total Primary Neoplasms 155 143 138 165 Total Animals with Benign Neoplasms 48 46 49 49 Total Benign Neoplasms 117 103 104 113 Total Animals with Malignant Neoplasms 31 33 28 40 Total Malignant Neoplasms 38 40 34 52 Total Animals with Metastatic Neoplasms 1 1 1 Total Metastatic Neoplasm 4 1 2 Total Animals with Malignant Neoplasms Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant Total Uncertain Neoplasms ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors Page 11 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------