TDMS Study 88120-03 Pathology Tables
NTP Experiment-Test: 88120-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:52:29
FINAL #1 CORE STUDY RATS
Facility: Battelle Columbus Laboratory
Chemical CAS #: 80-07-9
Lock Date: 08/11/98
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 88120-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:52:29
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 30 PPM 100 PPM 300 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Moribund Sacrifice 11 9 12 5
Natural Death 3 3 3 10
Survivors
Terminal Sacrifice 36 38 34 35
Natural Death 1
Animals Examined Microscopically 50 50 50 50
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ALIMENTARY SYSTEM
Intestine Small, Jejunum (50) (50) (50) (49)
Liver (50) (50) (50) (50)
Osteosarcoma, Metastatic, Spleen 1 (2%)
Schwannoma Malignant, Metastatic, Heart 1 (2%)
Mesentery (7) (8) (4) (4)
Sarcoma NOS, Metastatic, Uterus 1 (14%)
Pancreas (50) (50) (50) (50)
Adenoma 1 (2%)
Sarcoma NOS, Metastatic, Uterus 1 (2%)
Salivary Glands (50) (50) (50) (50)
Adenocarcinoma 1 (2%)
Stomach, Forestomach (50) (50) (50) (50)
Sarcoma Stromal, Metastatic, Uterus 1 (2%)
Stomach, Glandular (50) (50) (50) (50)
Tongue (2) (1)
Squamous Cell Carcinoma 1 (50%) 1 (100%)
Squamous Cell Papilloma 1 (50%)
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CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Schwannoma Malignant 1 (2%) 2 (4%) 2 (4%)
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ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Adenoma 2 (4%) 2 (4%) 1 (2%)
Sarcoma NOS, Metastatic, Uterus 1 (2%)
Adrenal Medulla (50) (49) (50) (50)
Pheochromocytoma Malignant 1 (2%)
NTP Experiment-Test: 88120-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:52:29
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 30 PPM 100 PPM 300 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Pheochromocytoma Benign 2 (4%)
Islets, Pancreatic (50) (50) (49) (50)
Adenoma 1 (2%)
Pituitary Gland (50) (49) (50) (50)
Schwannoma Malignant, Metastatic, Peripheral
Nerve 1 (2%)
Pars Distalis, Adenoma 23 (46%) 13 (27%) 17 (34%) 8 (16%)
Thyroid Gland (50) (50) (50) (50)
C-Cell, Adenoma 3 (6%) 8 (16%) 6 (12%) 2 (4%)
C-Cell, Adenoma, Multiple 2 (4%)
C-Cell, Carcinoma 2 (4%) 1 (2%)
Follicular Cell, Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1)
Leiomyoma 1 (100%)
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GENITAL SYSTEM
Clitoral Gland (47) (50) (50) (48)
Adenoma 1 (2%) 3 (6%) 1 (2%) 3 (6%)
Carcinoma 1 (2%) 1 (2%)
Ovary (50) (50) (50) (50)
Granulosa Cell Tumor Malignant 1 (2%)
Granulosa Cell Tumor Benign 1 (2%)
Sarcoma NOS, Metastatic, Uterus 1 (2%)
Uterus (50) (50) (50) (50)
Carcinoma 1 (2%)
Polyp Stromal 10 (20%) 8 (16%) 5 (10%) 5 (10%)
Sarcoma NOS 1 (2%)
Sarcoma Stromal 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Lymph Node (27) (23) (28) (28)
Lumbar, Carcinoma, Metastatic, Clitoral Gland 1 (4%)
Lymph Node, Mandibular (49) (50) (48) (50)
Lymph Node, Mesenteric (50) (50) (50) (50)
Spleen (50) (50) (50) (50)
Osteosarcoma 1 (2%)
Thymus (46) (48) (50) (48)
____________________________________________________________________________________________________________________________________
NTP Experiment-Test: 88120-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:52:29
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 30 PPM 100 PPM 300 PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50)
Adenoma 1 (2%)
Carcinoma 1 (2%) 1 (2%) 2 (4%)
Carcinoma, Multiple 1 (2%)
Fibroadenoma 12 (24%) 18 (36%) 19 (38%) 8 (16%)
Fibroadenoma, Multiple 3 (6%) 2 (4%) 1 (2%)
Myoepithelioma 1 (2%)
Skin (50) (50) (50) (49)
Pinna, Melanoma Malignant 1 (2%)
Subcutaneous Tissue, Fibroma 2 (4%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%) 1 (2%)
Subcutaneous Tissue, Lipoma 1 (2%) 1 (2%)
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MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1) (1)
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NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Astrocytoma Malignant 1 (2%) 1 (2%) 1 (2%)
Oligodendroglioma Malignant 1 (2%)
Peripheral Nerve (1) (1)
Trigeminal, Schwannoma Malignant 1 (100%)
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RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Alveolar/Bronchiolar Adenoma 1 (2%)
Carcinoma, Metastatic, Clitoral Gland 1 (2%)
Osteosarcoma, Metastatic, Spleen 1 (2%)
Sarcoma NOS, Metastatic, Uterus 1 (2%)
Mediastinum, Sarcoma NOS, Metastatic, Uterus 1 (2%)
Trachea (50) (50) (50) (50)
Sarcoma NOS 1 (2%)
____________________________________________________________________________________________________________________________________
NTP Experiment-Test: 88120-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:52:29
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 30 PPM 100 PPM 300 PPM
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Sarcoma NOS, Metastatic, Uterus 1 (2%)
Renal Tubule, Carcinoma 1 (2%)
Urinary Bladder (50) (50) (50) (50)
Sarcoma NOS, Metastatic, Uterus 1 (2%)
Transitional Epithelium, Papilloma 1 (2%)
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SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Leukemia Mononuclear 8 (16%) 7 (14%) 14 (28%) 14 (28%)
Lymphoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 88120-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:52:29
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 30 PPM 100 PPM 300 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 43 40 42 36
Total Primary Neoplasms 79 74 73 57
Total Animals with Benign Neoplasms 37 35 35 20
Total Benign Neoplasms 63 59 52 28
Total Animals with Malignant Neoplasms 16 14 20 25
Total Malignant Neoplasms 16 15 21 29
Total Animals with Metastatic Neoplasms 2 1 1 2
Total Metastatic Neoplasm 9 1 1 4
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
NTP Experiment-Test: 88120-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:52:29
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 10 PPM 30 PPM 100 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Moribund Sacrifice 19 16 24 15
Natural Death 7 4 6 7
Survivors
Terminal Sacrifice 24 30 20 28
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (50) (50) (50) (50)
Lipoma 1 (2%)
Polyp Adenomatous 1 (2%)
Intestine Large, Rectum (50) (50) (50) (50)
Intestine Large, Cecum (49) (50) (50) (50)
Intestine Small, Duodenum (50) (50) (50) (50)
Carcinoma 1 (2%)
Intestine Small, Jejunum (50) (50) (50) (50)
Intestine Small, Ileum (50) (50) (50) (50)
Liver (50) (50) (50) (50)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
Hepatocellular Carcinoma 2 (4%) 1 (2%)
Hepatocellular Adenoma 2 (4%)
Histiocytic Sarcoma 1 (2%)
Schwannoma Malignant, Metastatic, Skin 1 (2%)
Mesentery (7) (12) (12) (14)
Pancreas (50) (50) (50) (50)
Salivary Glands (50) (50) (50) (50)
Schwannoma Malignant 2 (4%) 1 (2%)
Schwannoma Malignant, Metastatic, Skin 1 (2%)
Stomach, Forestomach (50) (50) (50) (50)
Squamous Cell Carcinoma 1 (2%)
Stomach, Glandular (50) (50) (50) (50)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (50) (50) (50) (50)
Schwannoma Malignant, Metastatic, Skin 1 (2%)
Vena Cava, Pheochromocytoma Malignant,
Metastatic, Adrenal Medulla 1 (2%)
Heart (50) (50) (50) (50)
Schwannoma Malignant 1 (2%)
NTP Experiment-Test: 88120-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:52:29
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 10 PPM 30 PPM 100 PPM
____________________________________________________________________________________________________________________________________
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Adrenal Medulla (50) (50) (50) (50)
Pheochromocytoma Malignant 2 (4%) 2 (4%) 1 (2%)
Pheochromocytoma Malignant, Multiple 1 (2%)
Pheochromocytoma Benign 4 (8%) 3 (6%) 7 (14%) 1 (2%)
Islets, Pancreatic (50) (50) (50) (50)
Adenoma 2 (4%)
Carcinoma 1 (2%)
Pituitary Gland (50) (50) (50) (50)
Pars Distalis, Adenoma 11 (22%) 13 (26%) 7 (14%) 11 (22%)
Thyroid Gland (50) (50) (50) (50)
Sarcoma, Metastatic, Skin 1 (2%)
C-Cell, Adenoma 7 (14%) 6 (12%) 4 (8%) 7 (14%)
C-Cell, Adenoma, Multiple 1 (2%) 1 (2%) 1 (2%) 1 (2%)
C-Cell, Carcinoma 1 (2%) 1 (2%) 2 (4%)
Follicular Cell, Adenoma 1 (2%)
Follicular Cell, Carcinoma 1 (2%)
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GENERAL BODY SYSTEM
Peritoneum (1) (1)
Tissue NOS (1)
Thoracic, Schwannoma Malignant 1 (100%)
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GENITAL SYSTEM
Epididymis (50) (50) (50) (50)
Preputial Gland (50) (50) (50) (50)
Adenoma 3 (6%) 3 (6%) 1 (2%) 3 (6%)
Carcinoma 2 (4%) 1 (2%)
Prostate (50) (50) (50) (50)
Seminal Vesicle (50) (50) (50) (50)
Testes (50) (50) (50) (50)
Seminoma Malignant 1 (2%)
Interstitial Cell, Adenoma 2 (4%) 3 (6%) 2 (4%)
Interstitial Cell, Adenoma, Multiple 39 (78%) 43 (86%) 45 (90%) 47 (94%)
____________________________________________________________________________________________________________________________________
NTP Experiment-Test: 88120-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:52:29
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 10 PPM 30 PPM 100 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Lymph Node (15) (11) (14) (14)
Mediastinal, Squamous Cell Carcinoma,
Metastatic, Lung 1 (9%)
Lymph Node, Mandibular (50) (50) (49) (50)
Lymph Node, Mesenteric (50) (50) (50) (49)
Spleen (50) (50) (50) (50)
Sarcoma NOS 1 (2%)
Thymus (46) (47) (46) (47)
Squamous Cell Carcinoma, Metastatic, Lung 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (47) (50) (48) (50)
Adenoma 1 (2%)
Fibroadenoma 3 (6%) 6 (12%) 3 (6%) 2 (4%)
Skin (50) (50) (50) (50)
Basal Cell Adenoma 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Fibrous Histiocytoma 1 (2%)
Keratoacanthoma 3 (6%) 5 (10%) 2 (4%) 4 (8%)
Squamous Cell Papilloma 1 (2%)
Trichoepithelioma 1 (2%)
Subcutaneous Tissue, Fibroma 2 (4%) 2 (4%) 1 (2%) 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%) 1 (2%)
Subcutaneous Tissue, Hemangiosarcoma 1 (2%)
Subcutaneous Tissue, Lipoma 1 (2%) 1 (2%)
Subcutaneous Tissue, Melanoma Malignant 1 (2%)
Subcutaneous Tissue, Sarcoma NOS 1 (2%)
Subcutaneous Tissue, Schwannoma Malignant 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1) (2) (1)
Sarcoma NOS, Metastatic, Skin 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Ependymoma Malignant 1 (2%)
Glioma Malignant 1 (2%)
Meningioma Malignant 1 (2%)
Oligodendroglioma Malignant 2 (4%)
Spinal Cord (1)
NTP Experiment-Test: 88120-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:52:29
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 10 PPM 30 PPM 100 PPM
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Alveolar/Bronchiolar Adenoma 2 (4%) 2 (4%) 1 (2%)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Fibrous Histiocytoma, Metastatic, Liver 1 (2%)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
Hemangiosarcoma, Metastatic, Skin 1 (2%)
Pheochromocytoma Malignant, Metastatic,
Adrenal Medulla 1 (2%) 1 (2%) 1 (2%)
Schwannoma Malignant, Metastatic, Skin 1 (2%) 1 (2%) 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Carcinoma, Metastatic, Lung 1 (2%)
Nose (50) (50) (50) (50)
Trachea (50) (50) (50) (50)
Sarcoma, Metastatic, Skin 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1) (1) (1) (1)
Carcinoma 1 (100%) 1 (100%) 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Mesenchymal Tumor Malignant 1 (2%)
Urinary Bladder (50) (50) (50) (50)
Histiocytic Sarcoma, Metastatic, Liver 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Histiocytic Sarcoma 1 (2%)
Leukemia Mononuclear 27 (54%) 22 (44%) 25 (50%) 27 (54%)
Mesothelioma Malignant 2 (4%) 2 (4%) 5 (10%) 6 (12%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 10
NTP Experiment-Test: 88120-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99
Route: DOSED FEED Time: 12:52:29
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 10 PPM 30 PPM 100 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 49 50 50 50
Total Primary Neoplasms 122 126 121 127
Total Animals with Benign Neoplasms 42 48 47 50
Total Benign Neoplasms 81 89 77 84
Total Animals with Malignant Neoplasms 34 33 37 37
Total Malignant Neoplasms 41 37 44 43
Total Animals with Metastatic Neoplasms 4 4 1 2
Total Metastatic Neoplasm 9 7 3 2
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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