TDMS Study 88124-02 Pathology Tables
NTP Experiment-Test: 88124-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:04:54
FINAL#2, 13 WEEK SUBCHRONIC
Facility: Battelle Northwest
Chemical CAS #: 22398-80-7
Lock Date: 01/24/96
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 88124-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:04:54
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Inflammation, Focal | 1 1 1 | 3 1.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + M M M M M + | 4 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
Inflammation | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + M + + + | 9 |
__________________________________________________________________________|____________|
Ovary | + + + + + I + + + + | 9 |
__________________________________________________________________________|____________|
Oviduct | + | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + M + + | 9 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:04:54
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M M M M M M M M M | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 10 |
Inflammation, Suppurative | 1 | 1 1.0|
Necrosis | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Nephropathy | 1 | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:04:54
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
1.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + | 10 |
Hyperplasia | 3 2 2 2 2 3 2 2 3 2 | 10 2.3|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 | 10 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M M + M M + M M M | 2 |
Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
Hematopoietic Cell Proliferation | 2 1 2 | 3 1.7|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Skin | + | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:04:54
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
1.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Foreign Body | 2 2 3 2 2 2 2 3 2 2 | 10 2.2|
Inflammation, Chronic Active | 3 2 3 3 3 2 3 3 2 1 | 10 2.5|
Alveolar Epithelium, Hyperplasia | 1 1 2 2 1 1 1 1 2 1 | 10 1.3|
Alveolus, Proteinosis | 3 4 4 4 3 3 3 3 3 4 | 10 3.4|
Interstitium, Fibrosis | 1 1 1 1 1 1 1 1 1 1 | 10 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:04:54
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
3.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Vagina | + | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + | 10 |
Hyperplasia | 3 3 2 2 2 2 3 2 2 2 | 10 2.3|
Pigmentation | 1 1 2 1 1 1 1 1 1 1 | 10 1.1|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M + M M M M + M M | 3 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
Hematopoietic Cell Proliferation | 2 1 1 | 3 1.3|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 10 |
Foreign Body | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:04:54
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
3.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Squamous Epithelium, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
Foreign Body | 3 3 3 3 3 3 3 3 3 3 | 10 3.0|
Inflammation, Chronic Active | 3 2 2 2 1 2 3 2 3 2 | 10 2.2|
Alveolar Epithelium, Hyperplasia | 2 2 2 2 1 1 1 1 2 2 | 10 1.6|
Alveolus, Proteinosis | 4 3 3 4 3 3 4 4 3 4 | 10 3.5|
Interstitium, Fibrosis | 2 1 1 1 1 2 1 1 2 2 | 10 1.4|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Trachea | + + + I + + + + + + | 9 |
Foreign Body | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:04:54
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
10.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + | 10 |
Hyperplasia | 2 2 2 2 2 2 1 2 3 2 | 10 2.0|
Pigmentation | 2 1 2 1 1 1 1 1 1 1 | 10 1.2|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M M M M M M M M + | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 10 |
Foreign Body | 2 1 1 1 1 | 5 1.2|
Epiglottis, Metaplasia, Squamous | 1 1 1 2 | 4 1.3|
Squamous Epithelium, Hyperplasia | 1 1 2 1 | 4 1.3|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:04:54
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
10.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Foreign Body | 3 3 3 3 3 3 3 3 3 3 | 10 3.0|
Inflammation, Chronic Active | 3 2 3 4 3 3 3 3 3 3 | 10 3.0|
Alveolar Epithelium, Hyperplasia | 2 1 2 2 2 2 1 2 2 2 | 10 1.8|
Alveolus, Proteinosis | 4 4 3 4 4 4 4 4 3 4 | 10 3.8|
Interstitium, Fibrosis | 3 2 3 3 2 3 3 3 2 3 | 10 2.7|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
Foreign Body | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 10 |
Foreign Body | 1 1 1 1 1 1 | 6 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:04:54
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 2| 9| 9| 9| 9| 9| 9| 8| 9| 7| | |
| 4| 6| 4| 6| 6| 6| 6| 0| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
30.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Gallbladder | + + A + + + + M + + | 8 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + A + + + + A + + | 8 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + A + + | 9 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A + + + + A + + | 8 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A + + + + A + + | 8 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + M + + + + A + + | 8 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + + + + A + + | 8 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + A + + | 9 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 10 |
Degeneration | 1 1 1 | 3 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + A + + | 9 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + A + + | 9 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 10 |
Degeneration | 2 2 2 2 2 2 2 2 | 8 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + M + + + | 9 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + A + + | 9 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M M M M + + + + | 6 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + M | 9 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 10 |
Atrophy | 2 2 2 2 2 2 2 2 2 | 9 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 10 |
Atrophy | 2 1 2 1 | 4 1.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:04:54
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 2| 9| 9| 9| 9| 9| 9| 8| 9| 7| | |
| 4| 6| 4| 6| 6| 6| 6| 0| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
30.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + M + + M + + + + | 8 |
Hyperplasia | 1 3 2 2 3 3 | 6 2.3|
Pigmentation | 1 2 2 2 3 2 2 2 | 8 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + M + + M + M + + | 6 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + M + + | 9 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M + M M M M + M + | 4 |
Hyperplasia | 3 2 2 | 3 2.3|
Pigmentation | 2 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + A + + | 9 |
Hematopoietic Cell Proliferation | 1 1 1 2 2 1 | 6 1.3|
__________________________________________________________________________|____________|
Thymus | + + M + + + + + + + | 9 |
Atrophy | 1 4 1 | 3 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 10 |
Fat, Atrophy | 4 2 4 | 3 3.3|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 10 |
Subcutaneous Tissue, Hemorrhage | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 10 |
Hemorrhage | 2 | 1 2.0|
Necrosis, Focal | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 10 |
Foreign Body | 1 2 2 1 | 4 1.5|
Inflammation, Suppurative | 1 | 1 1.0|
Necrosis | 1 1 1 | 3 1.0|
Epiglottis, Metaplasia, Squamous | 2 1 1 1 1 | 5 1.2|
Squamous Epithelium, Hyperplasia | 3 2 2 2 3 2 2 | 7 2.3|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
Foreign Body | 4 4 4 4 4 4 4 3 4 4 | 10 3.9|
Inflammation, Chronic Active | 2 3 2 3 3 3 3 2 3 | 9 2.7|
Alveolar Epithelium, Hyperplasia | 1 3 4 3 4 4 3 2 3 4 | 10 3.1|
Alveolus, Proteinosis | 3 3 4 4 4 4 4 4 3 4 | 10 3.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:04:54
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 2| 9| 9| 9| 9| 9| 9| 8| 9| 7| | |
| 4| 6| 4| 6| 6| 6| 6| 0| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
30.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Interstitium, Fibrosis | 4 4 4 4 4 4 4 4 4 | 9 4.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
Foreign Body | 2 1 1 | 3 1.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 10 |
Foreign Body | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Infarct | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + A + + | 9 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:04:54
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 5| 6| 5| 6| 6| 5| 6| 5| 6| 5| | |
| 7| 3| 7| 0| 2| 9| 1| 8| 0| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
100.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 10 |
Degeneration | 1 2 2 1 1 2 1 1 2 | 9 1.4|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 10 |
Cardiomyopathy | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 10 |
Degeneration | 2 2 2 2 2 2 2 2 2 2 | 10 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M M M M + + M + + | 4 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + M + + | 9 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + M + + + M + + M + | 7 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 10 |
Atrophy | 2 2 2 2 2 2 2 2 2 | 9 2.0|
Cyst | 1 | 1 1.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 10 |
Atrophy | 2 3 3 2 2 3 2 2 | 8 2.4|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:04:54
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 5| 6| 5| 6| 6| 5| 6| 5| 6| 5| | |
| 7| 3| 7| 0| 2| 9| 1| 8| 0| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
100.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + | 10 |
Hyperplasia | 2 2 2 2 2 3 2 3 | 8 2.3|
Pigmentation | 3 2 3 2 2 1 3 2 3 | 9 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M + + + + + + | 9 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + M | 9 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + + M M + M + + + | 6 |
Hyperplasia | 2 | 1 2.0|
Pigmentation | 2 1 2 | 3 1.7|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
Hematopoietic Cell Proliferation | 1 1 1 2 1 | 5 1.2|
__________________________________________________________________________|____________|
Thymus | + + + + + M + + + + | 9 |
Atrophy | 3 3 2 3 2 4 3 3 4 | 9 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 10 |
Fat, Atrophy | 4 3 3 4 3 4 4 4 3 4 | 10 3.6|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 10 |
Foreign Body | 1 2 1 1 1 1 | 6 1.2|
Inflammation, Suppurative | 1 1 1 1 2 1 | 6 1.2|
Necrosis | 1 1 1 1 2 | 5 1.2|
Epiglottis, Metaplasia, Squamous | 1 2 1 2 2 | 5 1.6|
Squamous Epithelium, Hyperplasia | 1 2 3 3 3 3 2 1 3 3 | 10 2.4|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
Foreign Body | 4 4 4 4 4 4 4 4 4 4 | 10 4.0|
Inflammation, Chronic Active | 3 3 3 3 3 3 3 3 3 3 | 10 3.0|
Alveolar Epithelium, Hyperplasia | 4 4 4 4 4 4 4 4 4 4 | 10 4.0|
Alveolus, Proteinosis | 4 4 4 4 4 4 4 4 4 4 | 10 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:04:54
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 5| 6| 5| 6| 6| 5| 6| 5| 6| 5| | |
| 7| 3| 7| 0| 2| 9| 1| 8| 0| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
100.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Interstitium, Fibrosis | 4 4 4 4 4 4 4 4 4 4 | 10 4.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
Foreign Body | 2 2 1 1 2 1 2 1 2 1 | 10 1.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 10 |
Foreign Body | 1 1 1 1 2 | 5 1.2|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:04:54
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Necrosis, Focal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 10 |
Hypertrophy | 1 | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + M + M + | 7 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Testes | + + + + + + M + + + | 9 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:04:54
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + M M + + + | 8 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + M M + + + + + + | 7 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + M M + M M M + + | 4 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 10 |
Inflammation, Suppurative | 1 | 1 1.0|
Necrosis | 1 1 | 2 1.0|
Epiglottis, Metaplasia, Squamous | 1 | 1 1.0|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Nephropathy | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
Inflammation, Chronic | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:04:54
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
1.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + | 10 |
Hyperplasia | 3 3 3 2 3 3 3 2 2 2 | 10 2.6|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 | 10 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + M + + M M M | 6 |
Hyperplasia | 2 | 1 2.0|
Pigmentation | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
Hematopoietic Cell Proliferation | 1 1 1 2 1 | 5 1.2|
__________________________________________________________________________|____________|
Thymus | + + + + + + + I + + | 9 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 10 |
Foreign Body | 1 1 | 2 1.0|
Inflammation, Suppurative | 1 1 1 | 3 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:04:54
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
1.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Necrosis | 1 1 1 1 | 4 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
Foreign Body | 2 3 2 3 2 2 2 3 2 3 | 10 2.4|
Inflammation, Chronic Active | 3 3 3 3 2 3 2 3 2 3 | 10 2.7|
Alveolar Epithelium, Hyperplasia | 2 2 1 1 2 1 1 1 1 1 | 10 1.3|
Alveolus, Proteinosis | 4 3 4 4 4 4 3 4 3 3 | 10 3.6|
Interstitium, Fibrosis | 1 1 1 1 1 1 1 1 1 1 | 10 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:04:54
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
3.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + | 10 |
Hyperplasia | 3 2 2 2 2 2 2 2 2 2 | 10 2.1|
Pigmentation | 1 1 1 1 1 1 2 1 1 1 | 10 1.1|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M M M M M M M M M | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
Hematopoietic Cell Proliferation | 1 1 1 | 3 1.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 10 |
Foreign Body | 1 1 | 2 1.0|
Necrosis | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
Foreign Body | 3 3 3 3 3 3 3 3 3 3 | 10 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:04:54
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
3.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | 3 2 3 2 3 2 2 3 3 3 | 10 2.6|
Alveolar Epithelium, Hyperplasia | 2 2 1 1 1 1 1 2 1 2 | 10 1.4|
Alveolus, Proteinosis | 4 4 4 4 4 4 4 4 4 4 | 10 4.0|
Interstitium, Fibrosis | 2 2 1 1 1 1 1 2 2 3 | 10 1.6|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
Inflammation, Suppurative | 1 | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 10 |
Foreign Body | 1 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:04:54
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
10.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Liver | + | 1 |
Necrosis, Focal | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + | 10 |
Hyperplasia | 1 2 2 3 2 2 2 3 3 2 | 10 2.2|
Pigmentation | 1 1 1 1 2 2 2 1 1 1 | 10 1.3|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M + M + M M M M M | 3 |
Hyperplasia | 3 | 1 3.0|
Pigmentation | 1 | 1 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + I + | 9 |
Hematopoietic Cell Proliferation | 1 1 2 | 3 1.3|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 10 |
Foreign Body | 1 1 2 1 1 1 | 6 1.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:04:54
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
10.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Suppurative | 1 | 1 1.0|
Necrosis | 1 1 | 2 1.0|
Epiglottis, Metaplasia, Squamous | 1 1 1 1 1 1 1 1 1 | 9 1.0|
Squamous Epithelium, Hyperplasia | 1 2 1 | 3 1.3|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
Foreign Body | 3 4 3 4 4 4 3 3 3 3 | 10 3.4|
Inflammation, Chronic Active | 3 3 3 2 2 2 2 3 2 3 | 10 2.5|
Alveolar Epithelium, Hyperplasia | 4 3 3 4 4 3 3 3 2 2 | 10 3.1|
Alveolus, Proteinosis | 4 4 4 4 4 4 4 4 4 4 | 10 4.0|
Interstitium, Fibrosis | 4 3 4 3 4 2 3 3 2 3 | 10 3.1|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
Foreign Body | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 10 |
Foreign Body | 1 1 1 | 3 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:04:54
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 6| 1| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
30.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Gallbladder | + + M + + + + + + + | 9 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Necrosis, Focal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 10 |
Cardiomyopathy | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + M + + M M M + M | 4 |
__________________________________________________________________________|____________|
Pituitary Gland | M + + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Penis | + | 1 |
Inflammation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:04:54
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 6| 1| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
30.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + | 10 |
Hyperplasia | 3 2 1 2 2 3 2 2 | 8 2.1|
Pigmentation | 2 2 1 2 1 2 2 2 2 2 | 10 1.8|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M + + + + + M + + | 7 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + M + + + M + + + + | 8 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M M + + + M M + M | 5 |
Hyperplasia | 2 3 | 2 2.5|
Pigmentation | 2 3 | 2 2.5|
__________________________________________________________________________|____________|
Spleen | + + M + + + + + + + | 9 |
Hematopoietic Cell Proliferation | 3 1 1 1 2 2 | 6 1.7|
__________________________________________________________________________|____________|
Thymus | + M M M + + + + + + | 7 |
Atrophy | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 10 |
Foreign Body | 1 1 1 1 1 2 | 6 1.2|
Inflammation, Suppurative | 1 1 1 1 1 | 5 1.0|
Necrosis | 1 1 1 | 3 1.0|
Epiglottis, Metaplasia, Squamous | 1 1 1 1 1 1 1 1 | 8 1.0|
Squamous Epithelium, Hyperplasia | 2 2 3 3 3 2 1 1 2 | 9 2.1|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
Foreign Body | 4 4 4 4 4 4 4 4 4 4 | 10 4.0|
Inflammation, Chronic Active | 3 3 3 3 3 3 3 3 3 | 9 3.0|
Alveolar Epithelium, Hyperplasia | 4 4 4 4 4 4 4 4 3 4 | 10 3.9|
Alveolus, Proteinosis | 4 4 4 4 4 4 4 4 4 4 | 10 4.0|
Interstitium, Fibrosis | 4 4 4 4 3 4 4 4 4 4 | 10 3.9|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:04:54
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 6| 1| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
30.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Foreign Body | 1 | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 10 |
Foreign Body | 1 1 1 | 3 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:04:54
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 4| 5| 7| 4| 6| 5| 6| 6| 5| 5| | |
| 7| 6| 3| 7| 1| 3| 0| 3| 1| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
100.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + I + A + | 8 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + A + | 9 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + A + | 9 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + A + | 9 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Inflammation, Focal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
Ulcer | 1 | 1 1.0|
Epithelium, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 10 |
Cardiomyopathy | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + M + + + + + + + | 9 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M + + M M M + + M | 4 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Penis | + + | 2 |
Congestion | 1 | 1 1.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:04:54
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 4| 5| 7| 4| 6| 5| 6| 6| 5| 5| | |
| 7| 6| 3| 7| 1| 3| 0| 3| 1| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
100.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
Hyperplasia | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + + M + + + M + | 7 |
Hyperplasia | 2 2 2 2 1 2 2 | 7 1.9|
Pigmentation | 3 3 2 2 2 2 3 | 7 2.4|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + M M + + M + | 7 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M + + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M + + + M M M + + | 6 |
Hyperplasia | 2 1 2 | 3 1.7|
Pigmentation | 3 2 2 2 | 4 2.3|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
Hematopoietic Cell Proliferation | 2 2 3 1 2 2 2 1 2 | 9 1.9|
__________________________________________________________________________|____________|
Thymus | + M M + + M + + + + | 7 |
Atrophy | 1 1 3 3 3 3 3 | 7 2.4|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 10 |
Foreign Body | 3 1 2 1 | 4 1.8|
Inflammation, Suppurative | 1 1 1 1 | 4 1.0|
Necrosis | 1 1 1 1 | 4 1.0|
Epiglottis, Metaplasia, Squamous | 1 1 2 2 2 2 2 1 2 | 9 1.7|
Squamous Epithelium, Hyperplasia | 2 3 2 3 3 2 2 2 | 8 2.4|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
Foreign Body | 4 4 4 4 4 4 4 4 4 4 | 10 4.0|
Inflammation, Chronic Active | 3 3 3 3 3 3 3 3 3 3 | 10 3.0|
Alveolar Epithelium, Hyperplasia | 4 3 4 4 4 3 4 3 3 4 | 10 3.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 88124-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:04:54
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 4| 5| 7| 4| 6| 5| 6| 6| 5| 5| | |
| 7| 6| 3| 7| 1| 3| 0| 3| 1| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
100.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolus, Proteinosis | 4 4 4 4 4 4 4 4 4 4 | 10 4.0|
Interstitium, Fibrosis | 3 4 4 4 4 4 4 3 3 4 | 10 3.7|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
Foreign Body | 2 3 3 2 2 2 2 2 2 | 9 2.2|
Inflammation | 1 | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 10 |
Foreign Body | 3 1 2 | 3 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Infarct | 2 | 1 2.0|
Nephropathy | 1 | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
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